The new face of silver. Introducing ACTICOAT Flex The proven power of Nanocrystalline Silver in a flexible new form
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1 The new face of silver Introducing ACTICOAT Flex The proven power of Nanocrystalline Silver in a flexible new form
2 Introducing ACTICOAT Flex Setting a new standard for patient and ease of use ACTICOAT Flex provides highly effective antimicrobial protection Proven antimicrobial performance,,3 Highly flexible with stretch properties Rapid bactericidal effects within 30 minutes ACTICOAT Flex 3 ACTICOAT Flex 7 Mean log reduction (Log cfu/sample) S. aureus P. aeruginosa S. aureus P. aeruginosa Mean log reduction (Log cfu/sample) Low adherent wound contact layer Unique open-weave structure Both ACTICOAT Flex 3 and ACTICOAT Flex 7 showed bactericidal activity against S. aureus and P. aeruginosa within 30 minutes, Soft and conformable Moves with the patient to facilitate a able duration of wear Conforms to the anatomical area to maximize dressing contact and silver availability Helps minimize trauma on removal Easy to apply Unique stretch properties High conformability Sustained bactericidal effects against broad spectrum of wound pathogens Log reduction (Log cfu/sample) hr hr hr 7hr 68hr S. aureus MRSA VRE P. aeruginosa B. fragilis C. albicans A. niger Bactericidal effects were sustained for a full 7 days with ACTICOAT Flex 7 6 Both ACTICOAT Flex 3 and Flex 7 showed powerful efficacy against a broad spectrum of wound pathogens 3 including MRSA and Pseudomonas aeruginosa 6 3
3 ACTICOAT Flex was designed to handle fluid transport Choose the proven power of ACTICOAT ACTICOAT Flex has a unique open weave structure Allows easy fluid migration and transport, thus decreasing risk of maceration: - Comparable rates of fluid uptake for ACTICOAT Flex 7 + EXU-DRY vs. EXU-DRY alone 7 Compatible as a wound contact layer with Negative Pressure Wound Therapy for a period of 3 days 8,9 ACTICOAT reduced the time to wound closure in pediatric burn patients 0% fewer children treated with ACTICOAT required skin grafting (.% vs..6% with Silvazine; p=0) Despite an increase in the total number of new patients, the switch from Silvazine to ACTICOAT resulted in a % decrease in expenditure (from $0K to $6K) and a decrease in the number of inpatient bed days Days to heal 0 0 Calculation excluded patients requiring grafting Adapted from Cuttle et al, 07 p=7 Silvazine ACTICOAT ACTICOAT is more effective than the competition when dealing with infected wounds Only nanocrystalline silver reduced inflammation in skin affected by contact dermatitis in an in vivo study using a porcine wound model. 0 The skin with contact dermatitis treated with ACTICOAT was comparable to that of healthy controls after just 3 days and considerably healthier than skin treated with silver nitrate 60% of the ACTICOAT group demonstrated better performance when dealing with infected wounds (vs. less than 0% of either the Aquacel TM Ag group or Comfeel TM /Biatain TM Silver group) Performance in dealing with infected wounds (%) 00% 80% 60% 0% % 0% 60% 8% % ACTICOAT AquacelT Ag ComfeelT/BiatainT Silver Silver dressing evaluated Adapted from Verdu 07
4 Choose ACTICOAT Flex 3 & 7 for a range of indications For use on partial and full thickness wounds, including: First and second degree burns Covering of grafts Surgical sites Diabetic ulcers Venous ulcers Pressure ulcers ACTICOAT Flex the latest addition to the ACTICOAT range Chronic Wounds ACTICOAT 7 Features Code Description Pcs/ For multiple wound types 3 x Manages low to medium x 6 x 6 s/ 6 Burns/Soft Tissue Injuries ACTICOAT Flex 3 Features Code Description Pcs/ For first, second-degree x burns and traumatic wounds x Accommodates large soft tissue injuries with extralarge x 8 sizes x 6 6 Excellent flexibility and x x 8 6 Compatible with Negative Pressure Wound Therapy (NPWT) 3-day wear time Acute/Chronic Wounds ACTICOAT Flex 7 Features Code Description Pcs/ For multiple wound types x Accommodates large soft x tissue injuries with extralarge sizes x 6 Excellent flexibility and x x 6 6 Compatible with Negative Pressure Wound Therapy (NPWT) Burns/Chronic Wounds ACTICOAT Features Code Description Pcs/ For first- and second- degree 60 x burns 0 x For postoperative protection on surgical sites x Accommodates large burns x 8 with extra-large sizes 30 8 x 6 6 Manages low to medium 0 6 x x 8 Roll 6 3-day wear time s/ s/ 6 s/ Deep Cavity and Tunneling wounds Exudating Wounds ACTICOAT Absorbent Features Code Description Pcs/ For packing in deep cavity 8 3/ x Rope and tunneling wounds ACTICOAT Moisture Control Provides moderate absorption Gels on contact with 38 x Dressing Features Code Description Pcs/ For wound with moderate to x 0 high 3 x 0 Excellent absorption and x 8 0 Ideal for donor sites Insertion Sites ACTICOAT Site Features Code Description Pcs/ For vascular and nonvascular percutaneous device sites: IV, catheter, external fixator, drain tube Manages light to moderate 6 disc, slit and mm central opening Surgical Sites ACTICOAT Post-op Features Code Description Pcs/ For postoperative protection x 3/ on surgical sites x 8 Use in the OR after surgery and during recovery x 0 Manages light to moderate s/ s/ s/ 0 0 s/ 0 6 7
5 References. Smith & Nephew Wound Management. Data on file report Smith & Nephew Wound Management. Data on file report Smith & Nephew Wound Management. Data on file report Evaluation of extensibility - Smith and Nephew report reference DS.08.3.R.. ACTICOAT Dressing: Wound bed preparation and trauma 6. Smith & Nephew Wound Management. Data on file report In vitro study data on file: Scientific Background # Smith & Nephew Wound Management. Data on file report Bannister, N; NPWT study 0. Nadworny PL, et al. Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model. Nanomedicine 08;(3):-.. Cuttle L, et al. A retrospective cohort study of ACTICOAT versus Silvazine in a paediatric population. Burns 07;33(6): Verdu J et al. A comparison of the effectiveness of three silver dressings in the treatment of chronic infected wounds. PUBLITION DETAILS UNCLEAR. Wound Management Smith & Nephew, Inc. 970 Lake Carillon Drive Suite 0 St. Petersburg, FL 3376 USA Customer Care Center T F Smith & Nephew, Inc., All rights reserved. Trademark of Smith & Nephew. Certain marks Reg. US Pat. & TM Office. All other trademarks acknowledged. SILCRYST is a trademark of NUCRYST Pharmaceuticals Corp., used under license. ACT
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