PRESENTATION MATERIALS. Basic Chest Radiology for the TB Clinician
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1 PRESENTATION MATERIALS Basic Chest Radiology for the TB Clinician Adapted from the ISTC TB Training Modules 2009
2 Basic Radiology for the TB Clinician Objectives: At the end of this presentation, participants will be able to: Analyze the technical quality of chest X-rays (CXRs) using simple parameters Identify basic normal CXR anatomy on both frontal and lateral views Recognize radiographic patterns of disease and describe using appropriate terminology Describe both the typical and atypical patterns of radiographic presentation for pulmonary tuberculosis ISTC TB Training Modules
3 Basic Radiology for the TB Clinician (2) Overview: Technical aspects of chest radiography Systematic approach to reading CXR Basic CXR anatomy Patterns of disease Radiographic manifestations of tuberculosis (TB) ISTC TB Training Modules
4 Chest Radiography: Basic Principles X-ray photon: Absorbed / scattered / transmitted X-ray absorption depends on: Beam energy (constant) Tissue density Maximum X-Ray Transmission (least dense tissue) Maximum X-Ray Absorption (densest tissue) ISTC TB Training Modules 2009 Blackest air fat soft tissue calcium bone X-ray contrast metal Whitest 4
5 Differential X-Ray Absorption Why we see what we see: Structures are visible on a radiograph because of the juxtaposition of two different densities creating an interface Silhouette Sign Loss of an expected interface No boundary can be seen between two structures because they now are similar in density Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 5
6 Silhouette Sign: RLL Pneumonia Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 6
7 Silhouette Sign: RLL Pneumonia Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 6
8 Assess CXR Technical Quality Inspiratory effort 9-10 posterior ribs Penetration thoracic intervertebral disc space just visible Positioning / rotation medial clavicle heads equidistant from spinous process ISTC TB Training Modules
9 ISTC Image TB Training credit: Modules Curry 2009 International Tuberculosis Center, University of California, San Francisco 8
10 ISTC TB Training Modules Image credit: Curry International Tuberculosis Center, University of California, San Francisco 8
11 ISTC TB Training Modules Image credit: Curry International Tuberculosis Center, University of California, San Francisco 8
12 ISTC TB Training Modules Image credit: Curry International Tuberculosis Center, University of California, San Francisco 8
13 Inspiratory Effort Low Lung Volumes Full Inspiration Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 9
14 Exposure Overexposure Proper Exposure Image credit: Curry International Tuberculosis Center, University of California, San Francisco 10 ISTC TB Training Modules 2009
15 Overexposure Proper Exposure Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 11
16 ISTC TB Training Modules 2009 Rotated (Oblique) Image credit: Curry International Tuberculosis Center, University of California, San Francisco 12
17 Basic Radiology for the TB Clinician A systematic approach to reading a CXR Image ISTC TB Credit: Training Modules Lung Health 2009 Image Library/Gary Hampton 13
18 Approach to Reading a CXR Be Systematic Lungs Pleural surfaces Cardiomediastinal contours Bones and soft tissues Abdomen Image credit: Curry International Tuberculosis Center, University of California, San Francisco 14 ISTC TB Training Modules 2009
19 Worth a Second Look Apices Retrocardiac areas (left and right) Hilar regions Below diaphragm ISTC TB Training Modules
20 Apical TB Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 16
21 Apical TB (2) Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 17
22 Left Retrocardiac Opacity Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 18
23 Nodule Behind Diaphragm Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 19
24 Basic Radiology for the TB Clinician Basic CXR Anatomy Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 20
25 Basic CXR Anatomy Frontal and Lateral Views Heart Aorta Pulmonary arteries Airways Image Credit: Lung Health Image Library/Pierre Virot ISTC TB Training Modules
26 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 22
27 Aortic arch Right pulmonary artery Left pulmonary artery Trachea & bronchi Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 23
28 Aortic arch Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 23
29 Aortic arch Right pulmonary artery Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 23
30 Aortic arch Right pulmonary artery Left pulmonary artery Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 23
31 Aortic arch Right pulmonary artery Left pulmonary artery Trachea & bronchi Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 23
32 Basic Radiology for the TB Clinician Patterns of disease ISTC TB Training Modules
33 Chest Radiographic Patterns of Disease Consolidation / air-space opacity Interstitial opacity Nodules and masses Lymphadenopathy Cysts and cavities Pleural abnormalities ISTC TB Training Modules
34 Consolidation / Air-Space Opacity Caused by filling of alveoli with fluid, pus, blood, cells (tumor), etc. May be diffuse, or isolated to segments or lobes of the lung May be associated with air bronchograms (air-filled bronchus surrounded by opacified lung) ISTC TB Training Modules
35 Pneumonia Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 27
36 Interstitial Opacity Disease localized to pulmonary interstitium, i.e., the alveolar septae and connective tissues that support the alveoli Hallmarks: Lines and/or reticulation Small, well-defined nodules Miliary pattern DDX: Pulmonary edema, interstitial lung diseases (e.g., idiopathic pulmonary fibrosis), sarcoidosis, infection, tumor (lymphangitic spread), etc. ISTC TB Training Modules
37 Interstitial Opacity: Lines Image credit: Curry International Tuberculosis Center, University of California, San Francisco 29 ISTC TB Training Modules 2009
38 Interstitial Opacity: Lines Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 29
39 Interstitial Opacity: Lines & Reticulation Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 30
40 Nodules and Masses Nodule: discrete pulmonary lesion, sharply defined, nearly circular opacity cm Mass: larger than 3 cm Describe with qualifiers: Single or multiple Size Border characteristics Presence or absence of calcification Location ISTC TB Training Modules
41 Well-Defined Calcification Ill-Defined Mass Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 32
42 Lymphadenopathy (LAN) Non-specific terms: Mediastinal widening Hilar prominence Specific patterns: Particular station enlargement (location) Important to know what normal should look like in order to recognize abnormal ISTC TB Training Modules
43 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 34
44 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 34
45 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 34
46 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 34
47 Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 34
48 Lymphadenopathy Infrahilar window (right hilar and/or subcarinal) Left hilar Subcarinal Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 35
49 Lymphadenopathy Infrahilar window (right hilar and/or subcarinal) Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 35
50 Lymphadenopathy Left hilar Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 35
51 Lymphadenopathy Subcarinal Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 35
52 Right Paratracheal & Bilateral LAN Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 36
53 Right Hilar LAN Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 37
54 Right Hilar LAN Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 38
55 Subcarinal LAN * Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 39
56 AP Window LAN Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 40
57 Cysts & Cavities Abnormal pulmonary parenchymal spaces ( holes ), filled with air and/or fluid, with a definable wall (>1 mm) Cyst: congenital or acquired Cavity: caused by tissue necrosis, (inflammatory and/or neoplastic) Characterize: Wall thickness at thickest portion Inner lining Presence / absence of air / fluid level Number and location ISTC TB Training Modules
58 TB or Not TB? Cysts and Cavities Are there radiographic features that suggest benign vs. malignant diagnoses? A C 45 year old man from China with cough, weight loss B Image ISTC TB credit: Training Modules Curry International 2009 Tuberculosis Center, University of California, San Francisco 42 D
59 TB or Not TB? Cysts and Cavities (2) Are there radiographic features that suggest benign vs. malignant diagnoses? Benign cysts: uniform wall thickness, 1mm, smooth inner lining (e.g., PCP) Benign cavities: max. wall thickness 4 mm, minimally irregular inner lining (e.g., TB) ISTC TB Training Modules 2009 Malignant cavities: max. wall thickness 16 mm, irregular inner lining 43
60 Pleural Disease: Basic Patterns Effusion Angle blunting to massive Thickening Mass Air Calcification ISTC TB Training Modules
61 Pleural Effusion ISTC TB Training Modules
62 Post-TB Pleural Calcification ISTC TB Training Modules
63 Plombage with Lucite balls ISTC TB Training Modules
64 Basic Radiology for the TB Clinician Radiographic Manifestations of TB ISTC TB Training Modules
65 Can this be TB? Typical Pattern : Post-primary TB Distribution Apical / posterior segments of upper lobes Superior segments of lower lobes Isolated anterior segment involvement unusual for M.tb (think M. avium complex) ISTC TB Training Modules
66 Typical pattern : Post-Primary TB Patterns of disease Air-space consolidation Cavitation, cavitary nodule Endobronchial spread Miliary Bronchostenosis Tuberculoma Pleural effusions (empyema most likely in post-primary disease) ISTC TB Training Modules
67 Can this be TB? Atypical pattern : Primary TB Distribution : any lobe involved (slight lower lobe predominance) Air-space consolidation Cavitation is uncommon (<10%) Adenopathy is common (esp. children and HIV), predilection for right side Miliary pattern Pleural effusions ISTC TB Training Modules
68 Can this be TB? Miliary TB ISTC TB Training Modules
69 Radiographic Patterns: Pulmonary TB TB Pattern Infiltrate Typical (Post-Primary) 85% upper Atypical (Primary) Upper : Lower 60 : 40 Usually upper in children Cavitation Common Uncommon Adenopathy Uncommon Children common Adults ~30% Unilateral > bilateral Effusion May be present May be present ISTC TB Training Modules
70 CXR Pattern: Early vs. Advanced HIV Pattern Infiltrate Early HIV (CD4>200) Typical (Post-primary) Upper lobes Advanced HIV (CD4<200) Atypical (Primary) Lower lobes, multiple sites, or miliary Cavitation Common Uncommon Adenopathy Uncommon Common Effusion Uncommon More common ISTC TB Training Modules
71 Can this be TB? Old / Healed TB Ca ++ granuloma Ghon lesion Ca ++ granuloma and hilar node calcification Ranke complex Apical pleural thickening Fibrosis and volume loss ISTC TB Training Modules
72 Basic Radiology for the TB Clinician Summary: Remember: Technical quality can significantly impact your CXR interpretation Develop a systematic approach (and use it every time!) Practice identifying normal CXR anatomy Important to characterize and describe lesions this can help with your differential diagnosis Whether typical or atypical TB can always fool you! ISTC TB Training Modules
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