Radiology of Asbestos-related Diseases

Size: px
Start display at page:

Download "Radiology of Asbestos-related Diseases"

Transcription

1 8/25/03 9/19/03 Radiology of Asbestos-related Diseases Joan S. Hu,, Harvard Medical School Year III Gillian Lieberman, M.D.

2 Asbestos-related conditions I. Benign Pleural Disease II. III. IV. A. Pleural effusion B. Pleural plaques C. Diffuse pleural thickening D. Round atelectasis Asbestosis Malignant mesothelioma Bronchogenic carcinoma 2

3 Asbestos silicate mineral Fire-resistant, resistant, thermal & electrical insulator Insulation, brake pads, floor tiles, electric wiring, paints, cements. Serpentine fibers: chrysotile (>90%) curly & flexible Amphibole fibers: crocidolite, amosite stiff and straight Coated w/ ferritin ferruginous bodies 3

4 Imaging Modalities Chest radiograph: Screening tool International classification system for PA CXR in reference to standard radiographs Parenchymal dz: : shape, size, profusion Pleural thickening: site, width, extent, calcification HRCT: more sensitive than radiography 97% sens., 100% spec. in detection of pleural dz No international std Reserved for further eval: : clarifying pleural thickening, staging mesothelioma & lung CA, planning biopsy 4

5 I. Pleural effusion Earliest, w/n 10 yrs of exposure Hemorrhagic exudates Resolve over few MO s Diffuse pleural thickening often follows 5

6 Pt BR Pleural Effusion Bilateral pleural effusion Layered pleural effusion PA L lateral decubitus 6

7 Pleural Effusion Pt BR Pleural calcifications & thickening Pleural effusion Pleural thickening 7

8 DDx of Exudative Pleural Effusion Parapneumonic effusion TB Malignancy PE Pancreatitis Connective tissue dz Trauma Azotemia drugs 8

9 II. Pleural Plaques Fibrosis due to inflam.. reaction Usu. asymptomatic yrs after exposure 10-15% 15% calcify Conv. CT 95% sensitive, CXR 59%; HRCT 100%. 9

10 Distribution of plaques Usually from parietal pleura: Posterolateral chest wall th ribs Lateral chest wall 6-96 th ribs Dome of diaphragm (pathognomonic( pathognomonic) Mediastinal pleura Apices & costophrenic angles spared CT: anterior & paravertebral plaques Visceral plaques assoc d w/ parenchymal dz: Hairy plaques Extensive opacities 10

11 Pt WB Pleural Plaques pleural plaques 11

12 Pt SS Pleural Plaques Pleural plaques 12

13 Pt JT Pleural plaques Bilateral pleural plaques 13

14 Pleural Plaques Pt JT Calcified pleural plaques 14

15 Pleural Plaques Pt SS Calcification Pleural plaques calcification 15

16 DDx Pleural Plaques Adipose tissue (HRCT) Rib fracture Companion shadows for ribs (soft tissue) Pleural masses, e.g. mets 16

17 III. Diffuse Pleural Thickening Less specific for asbestos exposure Benign effusion inflam., thickening & fibrosis of visc.. pleura (lymphatics( lymphatics) fusion w/ parietal pleura Costophrenic angles & apices Irregular margins, continuous sheets, involves interlobar fissures (visc( visc.. pl.), resp. impairment: vs. plaques CT more sens.. & spec. than CXR (100% vs. 70%) 17

18 Diffuse Pleural Thickening Pt JM2 Pleural thickening 18

19 Diffuse Pleural Thickening Pt BR Pleural thickening 19

20 Diffuse Pleural Thickening Pt WB Pleural thickening 20

21 DDx Diffuse Pleural Thickening Organizing effusion Chronic infxn,, e.g. TB Connective tissue dz Talcosis Pleural mets mesothelioma 21

22 IV. Round Atelectasis Inflam rxn & fibrosis in pleura fibrous tissue contracts pleura folds into lung atelectasis aka asbestosis pseudotumor or Blesovsky Sx comet tail of bronchovascular struc s Usu w/ pleural thickening, volume loss Stable or shrinks w/ time MRI: T1 signal similar to liver; vasculature, visc.. pleura U/S: echogenic visc.. pleura 22

23 Pt BR Round Atelectasis CT supine Rounded atelectasis Pleural thickening Comet tail HRCT prone 23

24 Round Atelectasis Pt WB Round atelectasis w/ comet tail Pleural thickening 24

25 DDx Round Atelectasis Lung CA Pseudotumor (pleural effusion) Infection (e.g. round pneumonia, aspergillosis, histoplasmosis,, TB) sequestration 25

26 V. Asbestosis Lung fibrosis caused by asbestos dusts, +/- pleural fibrosis Dose responsive Lag yrs (short as 3 yrs w/ heavy expo) Neutrophils & macrophages release fibrogenic mediators fibrosis spreads from resp. bronchioles & alveolar ducts Lower lobes & subpleural middle lobe & lingula upper lobe in advanced dz 7-17% honeycombing (adv. dz) 26

27 CXR features of Asbestosis Ground Glass Opacities Small nodules Shaggy cardiac silhouette Ill-defined diaphragmatic contours Adv. dz: : honeycombing, volume loss 80% coexisting pleural dz (100% HRCT) Fibrous bands radiate inward from pleura 27

28 Pt JM2 Asbestosis Pleural thickening Shaggy cardiac silhouette Interstitial fibrosis Pleural plaques 28

29 HRCT for Asbestosis More sensitive than CXR Interstitial lines Parenchymal bands Early: subpleural curvilinear opacity (peribronchiolar fibrosis) GGO (alv( alv.. wall fibrosis) Subpleural dotlike nodular opacities Thickened interlobular septa Honeycombing 29

30 Pt JM2 Asbestosis GGO honeycombing Calcified pleural plaques 30

31 Asbestosis Pt WB Parenchymal band Septal thickening Pleural thickening 31

32 DDx Asbestosis Usual interstitial pneumonitis: Idiopathic pulmonary fibrosis Chronic drug toxicity Fibrosis due to collagen vascular dz (e.g. RA) 32

33 VI. Malignant Mesothelioma Pleura & peritoneum, can pericardium or tunica vaginalis testis Most common primary neoplasm of pleura Crocidolite, amosite Latency yrs Most pts die w/n 1 yr of dx. Either pleural layer CXR: usu. w/ effusion, pleural thickening retraction of chest wall Direct spread into surrounding mesothelial sacs, LN, hematogenous met 33

34 Malignant Mesothelioma Pt LF mesothelioma Pleural plaque 34

35 CT: Malignant Mesothelioma contraction of hemithorax,, extension along fissures, invasion. Nonaxial planes & MR for assessing infradiaphragmatic & chest wall invasion. 35

36 Malignant Mesothelioma Pt LF Mesothelioma (nodular thickening of pleura Pleural effusion 36

37 Pt LF Invasion Loculated pleural effusion Endobronchial invasion of distal left main bronchus Pericardial invasion 37

38 Infradiaphragmatic Invasion Pt LF Left diaphragm spleen Possible infradiaphragmatic extension adj. to spleen 38

39 DDx Malignant Mesothelioma Benign Pleural thickening infxn Diffuse pleural thickening Met adenoca Benign mesothelioma (solitary fibrous tumor) 39

40 VII. Bronchogenic Carcinoma Amphiboles (10-50x greater risk) Risk w/ combined asbestos exposure & smoking is multiplicative Variable latent period (~10-30 yrs) Anywhere in lungs 40

41 Pt JM1 Bronchogenic CA Bronchogenic CA 41

42 Pt JM1 Lymphadenopathy in Bronchogenic CA lymphadenopathy 42

43 Pt JM1 Metastasis met Met with blood products T2 susce 43

44 Bronchogenic CA Pt MF RUL adenoca 44

45 Fluorine-18 Fluorodeoxyglucose PET: Uptake of FDG in malignant mesothelioma & bronchogenic carcinoma much greater than benign pleural dz Nodal dz Less anatomic detail 45

46 F-18 FDG PET Tumor Pt MF Imaging Mediastinal lymph nodes CA 46

47 After Chemo- & Radiation Pt MF Therapy CA with spiculation 47

48 18-F F FDG PET after Chemo- Pt MF & Radiation Therapy Lymph nodes Esophagus, radiation induced changes Significant decrease in size & FDG intensity of mass 48

49 DDx Bronchogenic CA Pseudotumor Sequestration Round atelectasis Infection (fungal, granulomatous,, e.g. TB) Sarcoid Scarring Hamartoma Intrapulmonary lymph node AVM 49

50 Other Asbestos-related Diseases Peritoneal mesothelioma CA larynx & kidney Nodular pulmonary amyloidosis (?) 50

51 Review : I. Pleural Effusion Pt BR 51

52 Review: II. Pleural plaques Pt SS 52

53 Review: III. Diffuse Pleural Thickening Pt BR 53

54 Review: IV. Round Atelectasis Pt WB 54

55 Review: V. Asbestosis Pt JM2 55

56 Review: Pt LF VI. Malignant Mesothelioma 56

57 Review: Pt MF VII. Bronchogenic CA 57

58 Review: VIII. F-18 F FDG Pt MF PET Tumor Imaging 58

59 References Akira M, Yamamoto S, Inoue Y, Sakatani M. High-resolution CT of asbestosis and idiopathic pulmonary fibrosis. AJR Am J Roentgenol Jul;181(1): Begin R, Ostiguy G, Filion R, Groleau S. Recent advances in the early diagnosis of asbestosis. Semin Roentgenol Apr;27(2): Gamsu G. Computed tomography and high-resolution computed tomography of pneumoconioses. Occup Med Jul;33(7): Kim KI, Kim CW, Lee MK, Lee KS, Park CK, Choi SJ, Kim JG. Imaging of occupational lung disease. Radiographics Nov-Dec;21(6):1371 Dec;21(6): King, T.E. Jr. Asbestosis. UpToDate.com. Roach HD, Davies GJ, Attanoos R, Crane M, Adams H, Phillips S. Asbestos: when the dust settles an imaging review of asbestos-related disease. Radiographics Oct;22 Spec No:S Staples CA. Computed tomography in the evaluation of benign asbestos- related disorders. Radiol Clin North Am Nov;30(6): Stark, Paul. Imaging of pleural plaques, thickening, and tumors. UpToDate.com. 59

60 Acknowledgements Many thanks to: Dr. Michael Stella Pamela Lepkowski Dr. Hiroto Hatabu Larry Barbaras Dr. Gillian Lieberman Thanks for all your help! 60

UKRC 2015 Dr Michael Sproule Glasgow

UKRC 2015 Dr Michael Sproule Glasgow UKRC 2015 Dr Michael Sproule Glasgow Radiology of Asbestos Related Lung Disease General term given to a group of fibrous minerals containing silica and a variety of other elements. Asbestos: Derived

More information

Spectrum of Asbestosis and other Asbestos related diseases from a Radiological viewpoint

Spectrum of Asbestosis and other Asbestos related diseases from a Radiological viewpoint Aditya Pawaskar, Final Year Date of Rotation: 4/1/2013 to 4/28/2013 Spectrum of Asbestosis and other Asbestos related diseases from a Radiological viewpoint Aditya Pawaskar Lokmanya Tilak Municipal Medical

More information

Asbestos: The Range of Its Ill-Effects. Ezra Cohen, MS III Dr. Gillian Lieberman, MD Core Radiology Clerkship, BIDMC April 16 th, 2010

Asbestos: The Range of Its Ill-Effects. Ezra Cohen, MS III Dr. Gillian Lieberman, MD Core Radiology Clerkship, BIDMC April 16 th, 2010 Asbestos: The Range of Its Ill-Effects Ezra Cohen, MS III Dr. Gillian Lieberman, MD Core Radiology Clerkship, BIDMC April 16 th, 2010 Outline of Presentation Patient Presentation Anatomy Defining the disease

More information

Tina Mosaferi, Harvard Medical School Year III Gillian Lieberman, MD

Tina Mosaferi, Harvard Medical School Year III Gillian Lieberman, MD July 2014 Tina Mosaferi, Harvard Medical School Year III 1. Our Patient-Introduction 2. Asbestos Basics 3. Pulmonary Findings Manifestations demonstrated by companion patients 4. Our patient-conclusion

More information

Francine Lortie-Monette, MD, MSc, CSPQ, MBA Department of Epidemiology and Biostatistics University of Western Ontario 2003

Francine Lortie-Monette, MD, MSc, CSPQ, MBA Department of Epidemiology and Biostatistics University of Western Ontario 2003 ASBESTOS Francine Lortie-Monette, MD, MSc, CSPQ, MBA Department of Epidemiology and Biostatistics University of Western Ontario 2003 Asbestosis Asbestosis is a model for other dust diseases as well as

More information

Asbestos: When the Dust Settles An Imaging

Asbestos: When the Dust Settles An Imaging LUNGS S167 Asbestos: When the Dust Settles An Imaging Review of Asbestosrelated Disease 1 Huw D. Roach, FRCR Gareth J. Davies, FRCR Richard Attanoos, MRCPath Michael Crane, FRCR Haydn Adams, FRCR Siân

More information

Occupational Lung Disease. SS Visser Internal Medicine UP

Occupational Lung Disease. SS Visser Internal Medicine UP Occupational Lung Disease SS Visser Internal Medicine UP Classification Anorganic ( mineral ) dust/pneumoconiosis Fibrogenic - silica, asbestos, talc, silicates Non-fibrogenic - Fe, barium, tin Immunologic/Pharmcologic

More information

Mesothelioma: Questions and Answers

Mesothelioma: Questions and Answers CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Mesothelioma: Questions

More information

by Lee S. Newman, M.D., and Cecile S. Rose, M.D., M.P.H.

by Lee S. Newman, M.D., and Cecile S. Rose, M.D., M.P.H. OCCUPATIONAL ASBESTOSIS AND RELATED DISEASES by Lee S. Newman, M.D., and Cecile S. Rose, M.D., M.P.H. A 63-year-old man consulted an internist complaining of dyspnea on exertion. He reported the following:

More information

HEALTH CARE FOR EXPOSURE TO ASBESTOS. 2010 The SafetyNet Centre for Occupational Health and Safety Research Memorial University www.safetynet.mun.

HEALTH CARE FOR EXPOSURE TO ASBESTOS. 2010 The SafetyNet Centre for Occupational Health and Safety Research Memorial University www.safetynet.mun. HEALTH CARE FOR PATIENTS WITH EXPOSURE TO ASBESTOS 2010 The SafetyNet Centre for Occupational Health and Safety Research Memorial University www.safetynet.mun.ca HEALTH CARE FOR PATIENTS WITH EXPOSURE

More information

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours

Diseases. Inflammations Non-inflammatory pleural effusions Pneumothorax Tumours Pleura Visceral pleura covers lungs and extends into fissures Parietal pleura limits mediastinum and covers dome of diaphragm and inner aspect of chest wall. Two layers between them (pleural cavity) contains

More information

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background

Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the

More information

Asbestos related health risks

Asbestos related health risks Asbestos related health risks Pascal DUMORTIER *,** & Paul DE VUYST** *a-ulab ** Chest Department Hopital ERASME Asbestos related health risks Asbestos : some facts Asbestos related diseases Detection

More information

Lung Opacity: Atelectasis, Consolidation, Ground Glass Opacity, and Mosaic Attenuation

Lung Opacity: Atelectasis, Consolidation, Ground Glass Opacity, and Mosaic Attenuation Lung Opacity: Atelectasis, Consolidation, Ground Glass Opacity, and Mosaic Attenuation Gautham P. Reddy, MD, MPH University of Washington Learning Objectives Identify lobar or rounded atelectasis Describe

More information

Defending the Rest Basics on Lung Cancer, Other Cancers and Asbestosis: Review of the B-Read and Pulmonary Function Testing

Defending the Rest Basics on Lung Cancer, Other Cancers and Asbestosis: Review of the B-Read and Pulmonary Function Testing Defending the Rest Basics on Lung Cancer, Other Cancers and Asbestosis: Review of the B-Read and Pulmonary Function Testing ASBESTOSIS November 2013 Bruce T. Bishop Lucy L. Brandon Willcox & Savage 440

More information

Is CT screening for asbestos-related diseases rational?

Is CT screening for asbestos-related diseases rational? Is CT screening for asbestos-related diseases rational? Narufumi Suganuma, M.D. 1 Yukinori Kusaka, M.D. 1 Harumi Itoh, M.D. 2 1 Division of Environmental Health, Department of International, Social and

More information

Basic Chest X-ray Interpretation Programme 2

Basic Chest X-ray Interpretation Programme 2 Basic Chest X-ray Interpretation Programme 2 In this second chest x-ray tutorial I will now start to look at some of the more commonly encountered pathologies. I have split this up into abnormalities involving

More information

Primary -Benign - Malignant Secondary

Primary -Benign - Malignant Secondary TUMOURS OF THE LUNG Primary -Benign - Malignant Secondary The incidence of lung cancer has been increasing almost logarithmically and is now reaching epidemic levels. The overall cure rate is very low

More information

INFLAMMATORY PLEURAL EFFUSION

INFLAMMATORY PLEURAL EFFUSION PLEURA- LESIONS LESIONS OF PLEURA Primary Intra pleural bacterial infections Neoplasm (mesothelioma) Secondary A complication of some underlying disease PLEURAL EFFUSION Common manifestation of both primary

More information

Asbestos Disease: An Overview for Clinicians Asbestos Exposure

Asbestos Disease: An Overview for Clinicians Asbestos Exposure Asbestos Asbestos Disease: An Overview for Clinicians Asbestos Exposure Asbestos: A health hazard Exposure to asbestos was a major occupational health hazard in the United States. The first large-scale

More information

Male. Female. Death rates from lung cancer in USA

Male. Female. Death rates from lung cancer in USA Male Female Death rates from lung cancer in USA Smoking represents an interesting combination of an entrenched industry and a clearly drug-induced cancer Tobacco Use in the US, 1900-2000 5000 100 Per Capita

More information

Pulmonary interstitium. Interstitial Lung Disease. Interstitial lung disease. Interstitial lung disease. Causes.

Pulmonary interstitium. Interstitial Lung Disease. Interstitial lung disease. Interstitial lung disease. Causes. Pulmonary interstitium Interstitial Lung Disease Alveolar lining cells (types 1 and 2) Thin elastin-rich connective component containing capillary blood vessels Interstitial lung disease Increase in interstitial

More information

X-Rays. Interpretation of Chest Radiographs. X-ray Absorption. Tissue Density

X-Rays. Interpretation of Chest Radiographs. X-ray Absorption. Tissue Density X-Rays Interpretation of Chest Radiographs Reynard McDonald, MD Medical Director NJMS Global Tuberculosis Institute When x-rays are produced and directed toward the patient, they may act in three basic

More information

Pneumoconiosis. Jud W Gurney MD University of Nebraska. Welcome, in this presentation, I will review the dust disorders asbestosis and silicosis.

Pneumoconiosis. Jud W Gurney MD University of Nebraska. Welcome, in this presentation, I will review the dust disorders asbestosis and silicosis. Pneumoconiosis Jud W Gurney MD University of Nebraska Welcome, in this presentation, I will review the dust disorders asbestosis and silicosis. 1 Overview Fate of dust in the lung Inorganic lung disease

More information

Radiation-Induced Lung Injury

Radiation-Induced Lung Injury May 2001 Radiation-Induced Lung Injury Warren Phipps, Harvard Medical School Year III Our Patient D.C. is a 50 year-old woman with a 30-pack year history of smoking who presented to the ED because she

More information

Role of HRCT in Diagnosis of Asbestos Related Pleuro Pulmonary Disease

Role of HRCT in Diagnosis of Asbestos Related Pleuro Pulmonary Disease Cairo University Role of HRCT in Diagnosis of Asbestos Related Pleuro Pulmonary Disease ESSAY Submitted for partial fulfillment of Master degree in Radio-diagnosis By Rania Adel Abd ElRahem Elghetany (M.B.B.CH.,

More information

Environmental Lung Disease (Pneumoconiosis) AGAINDRA K. BEWTRA M.D.

Environmental Lung Disease (Pneumoconiosis) AGAINDRA K. BEWTRA M.D. Environmental Lung Disease (Pneumoconiosis) AGAINDRA K. BEWTRA M.D. Pneumoconiosis Originally pneumoconiosis (gr: Pneumo = lung; konis = dust). So it was those diseases caused by dust inhalation, but in

More information

Naturally Occurring Asbestos (NOA) General Overview

Naturally Occurring Asbestos (NOA) General Overview Naturally Occurring Asbestos (NOA) General Overview Lee R. Shull PhD Health, Ecology and Risk Practice MWH Global Sacramento, CA CASH NOA Workshop January 24, 2006 Presentation Outline Brief background

More information

P L E U R A L M E S O T H E L I O M A

P L E U R A L M E S O T H E L I O M A For media outside the US, UK and Canada only P L E U R A L M E S O T H E L I O M A 1. Overview 2. What is pleural mesothelioma? 3. How common is pleural mesothelioma? 4. What are the risk factors for pleural

More information

The Radiology of Tuberculosis

The Radiology of Tuberculosis The Radiology of Tuberculosis David Ashkin, M.D., F.C.C.P. Medical Director, Southeastern National Tuberculosis Center Medical Director, Florida Bureau of TB and Refugee Health Clinical Assistant Professor,

More information

X-Rays. Interpretation of Chest Radiographs. X-ray Absorption. Tissue Density

X-Rays. Interpretation of Chest Radiographs. X-ray Absorption. Tissue Density X-Rays Interpretation of Chest Radiographs Reynard McDonald, MD Medical Director NJMS Global Tuberculosis Institute When x-rays are produced and directed toward the patient, they may act in three basic

More information

3- B ~ E. Asbestos-Related Respiratory Diseases

3- B ~ E. Asbestos-Related Respiratory Diseases 3- B ~ E. Asbestos-Related Respiratory Diseases Takumi Kishimoto Deputy-director, Okayama Rosai Hospital, Japan Summary For the pulmonary diseases arising from asbestos there are benign lesions from asbestosis

More information

Sir William Osler: Listen to the patient; the patient tells you everything.

Sir William Osler: Listen to the patient; the patient tells you everything. Sir William Osler: Listen to the patient; the patient tells you everything. Jean-Martin Charcot: The patient is a liar. Epidemiology of Mesothelioma Jeffrey H. Mandel, MD, MPH Division of Environmental

More information

Interstitial lung disease in a rheumatic electrician

Interstitial lung disease in a rheumatic electrician Interstitial lung disease in a rheumatic electrician Case history The case presented here concerns a male, born in 1931, who was an electrician for 34 years. He had frequent and close contact with asbestos,

More information

What is Mesothelioma?

What is Mesothelioma? What is Mesothelioma? Mesothelioma is a rare type of cancer that develops in the mesothelial cells found in one s body. These cells form membranous linings that surround and protect the body s organs and

More information

Fibrous Tumor of the Pleura. Milena Petranovic, HMS IV Gillian Lieberman, MD June 17, 2008

Fibrous Tumor of the Pleura. Milena Petranovic, HMS IV Gillian Lieberman, MD June 17, 2008 Fibrous Tumor of the Pleura Milena Petranovic, HMS IV Gillian Lieberman, MD June 17, 2008 Our Patient: 39-year old asymptomatic female Mass on Chest X-ray PA BIDMC, PACS Lateral BIDMC, PACS Well-circumscribed,

More information

Disorders of Known Causes: Occupational Lung Diseases/Pneumoconioses andenvironmental Lung Disease

Disorders of Known Causes: Occupational Lung Diseases/Pneumoconioses andenvironmental Lung Disease Disorders of Known Causes: Occupational Lung Diseases/Pneumoconioses andenvironmental Lung Disease Restrictive lung diseases; low lung volumes WE KNOW the causes Asbestosis Silicosis Coal Worker s pneumoconiosis

More information

Determination of Asbestos Exposure by Pathology and Clinical History

Determination of Asbestos Exposure by Pathology and Clinical History 16 Determination of Asbestos Exposure by Pathology and Clinical History Allen R. Gibbs The determination of whether an abnormal asbestos exposure took place is important in mesothelioma cases because of

More information

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1 Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this

More information

Asbestos and the diseases it causes

Asbestos and the diseases it causes Asbestos and the diseases it causes October 2013 Liz Darlison Mesothelioma UK University Hospitals of Leicester Contents What is asbestos Why is it such an issue in the UK Disease Statistics Asbestos Related

More information

Uses and Abuses of Pathology in Asbestos-exposed Populations

Uses and Abuses of Pathology in Asbestos-exposed Populations Uses and Abuses of Pathology in Asbestos-exposed Populations Jerrold L. Abraham, MD Department of Pathology State University of New York Upstate Medical University Syracuse, NY, 13210 USA The term: Asbestosis,

More information

NISG Asbestos. Caroline Kirton

NISG Asbestos. Caroline Kirton NISG Asbestos Caroline Kirton 1 The Control of Asbestos Regulations 2012, Regulation 10 requires every employer to ensure that adequate information, instruction and training is given to their employees

More information

MONTH OF ISSUE: October 2011 TO: MANAGERS, SUPERVISORS, GENERAL FOREMEN & CREWS SUBJECT: Asbestos Alert

MONTH OF ISSUE: October 2011 TO: MANAGERS, SUPERVISORS, GENERAL FOREMEN & CREWS SUBJECT: Asbestos Alert MONTH OF ISSUE: October 2011 TO: MANAGERS, SUPERVISORS, GENERAL FOREMEN & CREWS SUBJECT: Asbestos Alert On the 21/09/2011 at approximately 10.30 am one of our worksites was inspected by a NSW Workcover

More information

Restrictive lung diseases

Restrictive lung diseases Restrictive lung diseases Characterized by reduced compliance of the lung. Prominent changes in the interstitium (interstitial lung disease). Important signs and symptoms: - Dyspnea. - Hypoxia. - With

More information

Asbestos risks, safety and its role in lung disease

Asbestos risks, safety and its role in lung disease Asbestos risks, safety and its role in lung disease Fraser Brims Respiratory Physician, SCGH Head of Occupa9onal and Respiratory Health Unit, Ins9tute for Lung Health, WA Lung Founda9on Australia Educa9on

More information

Survey of Mesothelioma Associated with Asbestos Exposure in Japan

Survey of Mesothelioma Associated with Asbestos Exposure in Japan The research and development and the dissemination projects related to the 13 fields of occupational injuries and illnesses Survey of Mesothelioma Associated with Asbestos Exposure in Japan Clinical characteristics

More information

Cystic Lung Diseases. Melissa Price Gillian Lieberman, MD Advanced Radiology Clerkship Beth Israel Deaconess Medical Center November, 2008

Cystic Lung Diseases. Melissa Price Gillian Lieberman, MD Advanced Radiology Clerkship Beth Israel Deaconess Medical Center November, 2008 Cystic Lung Diseases Melissa Price Gillian Lieberman, MD Advanced Radiology Clerkship Beth Israel Deaconess Medical Center November, 2008 How do we define a cyst of the lung? Hansell DM, Bankier AA, MacMahon

More information

Introduction. Case Report

Introduction. Case Report DOI: 10.4046/trd.2009.67.4.369 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2009;67:369-373 CopyrightC2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

More information

Sternotomy and removal of the tumor

Sternotomy and removal of the tumor Sternotomy and removal of the tumor All thymomas originate from epithelial thymic cells 4% of them consist of a pure population of epithelial cells Most have mixed populations of lymphoid cells to a

More information

Malignant Mesothelioma Versus Metastatic Carcinoma of the Pleura: A CT Challenge

Malignant Mesothelioma Versus Metastatic Carcinoma of the Pleura: A CT Challenge Iran J Radiol. 2016 January; 13(1): e10949. Published online 2015 November 14. CHEST IMAGING DOI: 10.5812/iranjradiol.10949 Research Article Malignant Mesothelioma Versus Metastatic Carcinoma of the Pleura:

More information

Understanding Pleural Mesothelioma

Understanding Pleural Mesothelioma Understanding Pleural Mesothelioma UHN Information for patients and families Read this booklet to learn about: What is pleural mesothelioma? What causes it? What are the symptoms? What tests are done to

More information

BE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley

BE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley BE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley Outline: 1) Toxicological mechanisms and causation evaluations 2) An environetics case: Asbestos and Mesothelioma Toxicological

More information

Clinical, Radiological, and Pathological Investigation of Asbestosis

Clinical, Radiological, and Pathological Investigation of Asbestosis Int. J. Environ. Res. Public Health 2011, 8, 899-912; doi:10.3390/ijerph8030899 OPEN ACCESS Article International Journal of Environmental Research and Public Health ISSN 1660-4601 www.mdpi.com/journal/ijerph

More information

American Thoracic Society Documents

American Thoracic Society Documents American Thoracic Society Documents Diagnosis and Initial Management of Nonmalignant Diseases Related to Asbestos This official statement of the American Thoracic Society was adopted by the ATS Board of

More information

CHEST IMAGING RADIOLOGY FUNDAMENTALS: UNDERSTANDING THE CHEST X- RAY RADIOGRAPHIC DENSITIES. Hounsfield Units 10/15/2013

CHEST IMAGING RADIOLOGY FUNDAMENTALS: UNDERSTANDING THE CHEST X- RAY RADIOGRAPHIC DENSITIES. Hounsfield Units 10/15/2013 CHEST IMAGING RADIOLOGY FUNDAMENTALS: UNDERSTANDING THE CHEST X- RAY RADIOGRAPHIC DENSITIES What are the different basic radiographic densities? Density Characteristics 1. Metal 2. Bone 3. Soft Tissue

More information

Asbestos Diseases Uncovered

Asbestos Diseases Uncovered Asbestos Diseases Uncovered Your complete download & keep guide to asbestos-related diseases. Their symptoms, causes and potential compensation payable Contents What is Asbestos? What diseases are caused

More information

Asbestos Related Diseases

Asbestos Related Diseases Asbestos Related Diseases Asbestosis Mesothelioma Lung Cancer Pleural Disease Asbestosis and Mesothelioma (LUNG CANCER) Support Group 1800 017 758 www.amsg.com.au ii Helping you and your family through

More information

Differentiating between Benign Pleuritis and Mesothelioma by Radiograph using ILO 2000 Classification

Differentiating between Benign Pleuritis and Mesothelioma by Radiograph using ILO 2000 Classification Table of Contents PL-4-13 Narufumi Suganuma Differentiating between Benign Pleuritis and Mesothelioma by Radiograph using ILO 2000 Classification Yukinori Kusaka and Narufumi Suganuma Department of Environmental

More information

SUMMARY OF S.B. 15 ASBESTOS/SILICA LITIGATION REFORM BILL

SUMMARY OF S.B. 15 ASBESTOS/SILICA LITIGATION REFORM BILL SUMMARY OF S.B. 15 ASBESTOS/SILICA LITIGATION REFORM BILL S.B. 15, the asbestos/silica litigation reform bill, distinguishes between the claims of people who are physically impaired or sick due to exposure

More information

Consensus report. Asbestos, asbestosis, and cancer: the Helsinki criteria for diagnosis and altribu tion. Scand J Work En viron Health 1997;23:3 1 1-6

Consensus report. Asbestos, asbestosis, and cancer: the Helsinki criteria for diagnosis and altribu tion. Scand J Work En viron Health 1997;23:3 1 1-6 Scand J Work En viron Health 1997;23:3 1 1-6 Asbestos, asbestosis, and cancer: the Helsinki criteria for diagnosis and altribu tion The International Expert Meeting on Asbestos, Asbestosis, and Cancer

More information

Neoplasms of the LUNG and PLEURA

Neoplasms of the LUNG and PLEURA Neoplasms of the LUNG and PLEURA 2015-2016 FCDS Educational Webcast Series Steven Peace, BS, CTR September 19, 2015 2015 Focus o Anatomy o SSS 2000 o MPH Rules o AJCC TNM 1 Case 1 Case Vignette HISTORY:

More information

Disease/Illness GUIDE TO ASBESTOS LUNG CANCER. What Is Asbestos Lung Cancer? www.simpsonmillar.co.uk Telephone 0844 858 3200

Disease/Illness GUIDE TO ASBESTOS LUNG CANCER. What Is Asbestos Lung Cancer? www.simpsonmillar.co.uk Telephone 0844 858 3200 GUIDE TO ASBESTOS LUNG CANCER What Is Asbestos Lung Cancer? Like tobacco smoking, exposure to asbestos can result in the development of lung cancer. Similarly, the risk of developing asbestos induced lung

More information

Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro. Joon H. Lee 9/17/2012

Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro. Joon H. Lee 9/17/2012 Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro Joon H. Lee 9/17/2012 Malignant Pleural Mesothelioma (Epidemiology) Incidence: 7/mil (Japan) to 40/mil (Australia) Attributed secondary to asbestos

More information

PARTICLE SIZE AND CHEMISTRY:

PARTICLE SIZE AND CHEMISTRY: Pneumoconioses LW/Please note: This information is additional to Davidson s Principles and Practice of Medicine. /Hierdie inligting is aanvullend tot Davidson s Principles and Practice of Medicine. Pneumoconioses

More information

HOW TO READ A CHEST X-RAY

HOW TO READ A CHEST X-RAY The Radiology of TB Michael Lauzardo, MD MSc Director, Southeastern National Tuberculosis Center Chief, Infectious Diseases and Global Medicine University of Florida Objectives How to read a Chest X-Ray

More information

WA Asbestos Review Program

WA Asbestos Review Program WA Asbestos Review Program Dr Fraser Brims Consultant Respiratory Physician, SCGH, Head of Occupational and Respiratory Health Unit, LIWA Asbestos awareness week seminar, 2014 Introduction Asbestos and

More information

General Thoracic Surgery ICD9 to ICD10 Crosswalks. C34.11 Malignant neoplasm of upper lobe, right bronchus or lung

General Thoracic Surgery ICD9 to ICD10 Crosswalks. C34.11 Malignant neoplasm of upper lobe, right bronchus or lung ICD-9 Code ICD-9 Description ICD-10 Code ICD-10 Description 150.3 Malignant neoplasm of upper third of esophagus C15.3 Malignant neoplasm of upper third of esophagus 150.4 Malignant neoplasm of middle

More information

Toxicity of Amphibole Asbestos

Toxicity of Amphibole Asbestos Toxicity of Amphibole Asbestos Disclaimer: The material presented in these slides has been reviewed by the U.S. EPA and approved for presentation. Approval does not signify that the contents necessarily

More information

Malignant Pleural Diseases Advances Clinicians Should Know F Gleeson

Malignant Pleural Diseases Advances Clinicians Should Know F Gleeson Malignant Pleural Diseases Advances Clinicians Should Know F Gleeson The following relevant disclosures, conflicts of interest and/ or financial relationships exist related to this presentation: Consultant

More information

Asbestos Related Diseases. Asbestosis Mesothelioma Lung Cancer Pleural Disease. connecting raising awareness supporting advocating

Asbestos Related Diseases. Asbestosis Mesothelioma Lung Cancer Pleural Disease. connecting raising awareness supporting advocating Asbestos Related Diseases Asbestosis Mesothelioma Lung Cancer Pleural Disease connecting raising awareness supporting advocating 1800 017 758 www.asbestosassociation.com.au Asbestos lagging was widely

More information

Basic Data. 鍾 XX, female Age:59 y/o

Basic Data. 鍾 XX, female Age:59 y/o Basic Data 鍾 XX, female Age:59 y/o Chief complain for evaluation of the left pleural mass Clinical course This 59 years old lady Hypertension for 3 years, under herbal control. An episode of high BP up

More information

Anatomy Pleura Visceral Layer outer surface of lung Separates lobes of lung from each other Parietal Layer inner surface chest wall Pleural linings Co

Anatomy Pleura Visceral Layer outer surface of lung Separates lobes of lung from each other Parietal Layer inner surface chest wall Pleural linings Co Pleural diseases Dr. JM Nel Department of Pulmonology Pleural diseases Anatomy Empyema Physiology Pleurisy Pleural effusion Spontaneous Pneumothorax Asbestos- related pleural disease 1 Anatomy Pleura Visceral

More information

Plueral Malignancy: Radiologic-pathologic

Plueral Malignancy: Radiologic-pathologic Plueral Malignancy: Radiologic-pathologic Correlation Ritu R. Gill, MD Pleural Malignancies: Radiologic-Pathologic Correlation Ritu R Gill MD Brigham and Women s Hospital Boston, Massachusetts Pleural

More information

BASELINE HEALTH MONITORING BEFORE STARTING ASBESTOS RELATED WORK OR REMOVAL WORK

BASELINE HEALTH MONITORING BEFORE STARTING ASBESTOS RELATED WORK OR REMOVAL WORK ASBESTOS BASELINE HEALTH MONITORING BEFORE STARTING ASBESTOS RELATED WORK OR REMOVAL WORK 1. Collection of demographic data 2. Work history 3. Medical History Administration of a standardised respiratory

More information

MY9700691. CT of Pleural Abnormalities CH4-CHEST

MY9700691. CT of Pleural Abnormalities CH4-CHEST CH4-CHEST CT of Pleural Abnormalities W. Richard Webb Dept of Radiology, University of California of San Francisco, San Francisco 3) MY9700691 which the soft-tissue opacity parietal pleura and innermost

More information

Efficiently Maintaining Commercial Buildings. Asbestos Awareness

Efficiently Maintaining Commercial Buildings. Asbestos Awareness Efficiently Maintaining Commercial Buildings Asbestos Awareness What are the risks? Asbestos was used extensively between the 1950s and 1980s in both domestic and commercial buildings and although its

More information

Asbestos - Frequently Asked Questions

Asbestos - Frequently Asked Questions Asbestos - Frequently Asked Questions 1. What is asbestos? Asbestos is the name given to a group of fibrous minerals which occur naturally in the earth. These are grouped into two mineral types known as

More information

Recommendations for the Reporting of Pleural Mesothelioma

Recommendations for the Reporting of Pleural Mesothelioma Recommendations for the Reporting of Pleural Mesothelioma Association of Directors of Anatomic and Surgical Pathology * DOI: 10.1309/6A30YQHBMTHEJTEM It has been evident for decades that pathology reports

More information

Chest X-ray Interpretation for the Clinician

Chest X-ray Interpretation for the Clinician Chest X-ray Interpretation for the Clinician Karen Laframboise Associate Professor of Medicine Division of Respirology, Critical Care and Sleep Medicine University of Saskatchewan Chest X-ray Interpretation

More information

Asbestos Awareness at the University of Toronto

Asbestos Awareness at the University of Toronto Asbestos Awareness at the University of Toronto What is Asbestos? Asbestos is a general term given to a group of naturally occurring mineral silicates that are made up of long thin fibres. These fibrous

More information

Health effects of occupational exposure to asbestos dust

Health effects of occupational exposure to asbestos dust Health effects of occupational exposure to asbestos dust Authors: N.Szeszenia-Dąbrowska, U.Wilczyńska The major health effects of workers' exposure to asbestos dust include asbestosis, lung cancer and

More information

ASBESTOS DISEASES. Dr Alastair Robertson

ASBESTOS DISEASES. Dr Alastair Robertson ASBESTOS DISEASES Dr Alastair Robertson Occupational Health Department University Hospital Birmingham Birmingham B29 6JF 01216278285 Alastair.robertson@uhb.nhs.uk Occupational Lung Disease Unit Birmingham

More information

MESOTHELIOMA. Not Just a Late Night Commercial. Graciela Hoal, RN, MSN, ACNP-BC

MESOTHELIOMA. Not Just a Late Night Commercial. Graciela Hoal, RN, MSN, ACNP-BC MESOTHELIOMA Not Just a Late Night Commercial Graciela Hoal, RN, MSN, ACNP-BC Saturday Session Thoracic Surgery Nurse Practitioner Greater Los Angeles Veteran Affairs Objectives Course Objectives: Discuss

More information

WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1894/06

WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1894/06 WORKPLACE SAFETY AND INSURANCE APPEALS TRIBUNAL DECISION NO. 1894/06 BEFORE: R. Nairn : Vice-Chair HEARING: September 25, 2006 at Windsor Oral DATE OF DECISION: October 16, 2006 NEUTRAL CITATION: 2006

More information

Occupational Lung diseases. Dr Deepak Aggarwal Dept. Of Pulmonary Medicine

Occupational Lung diseases. Dr Deepak Aggarwal Dept. Of Pulmonary Medicine Occupational Lung diseases Dr Deepak Aggarwal Dept. Of Pulmonary Medicine To be discussed. Pneumoconiosis Hypersensitivity Pneumonitis PNEUMOCONIOSIS Pneumoconioses are pulmonary diseases caused by mineral

More information

Occupational Lung Disease. David Perlman, MD

Occupational Lung Disease. David Perlman, MD Occupational Lung Disease David Perlman, MD What causes occupational lung diseases? Breathing bad stuff into your lung Mechanism of particle deposition Large particles (>0.5μM) Impaction Gravitational

More information

Asbestos: health effects and risk. Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA

Asbestos: health effects and risk. Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA Asbestos: health effects and risk Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA What is asbestos Naturally occurring mineral that has crystallised to form long thin fibres and

More information

More than 2,500 people are diagnosed with mesothelioma in the UK each year.

More than 2,500 people are diagnosed with mesothelioma in the UK each year. This information is an extract from the booklet Understanding mesothelioma. You may find the full booklet helpful. We can send you a free copy see page 5. Contents Introduction Pleural mesothelioma Peritoneal

More information

Testimony of. Dr. James Crapo. April 26, 2005

Testimony of. Dr. James Crapo. April 26, 2005 Testimony of Dr. James Crapo April 26, 2005 Written Statement of Dr. James D. Crapo, Professor of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center

More information

Frequently Asked Questions

Frequently Asked Questions This fact sheet was written by the Agency for Toxic Substances and Disease Registry (ATSDR), a federal public health agency. ATSDR s mission is to serve the public by using the best science, taking responsive

More information

Malignant Mesothelioma

Malignant Mesothelioma Malignant Malignant mesothelioma is a tumour originating from mesothelial cells. 85 95% of mesotheliomas are caused by asbestos exposure. It occurs much more commonly in the chest (malignant pleural mesothelioma)

More information

Malignant Mesothelioma

Malignant Mesothelioma Malignant mesothelioma is a tumour originating from mesothelial cells. 85 95% of mesotheliomas are caused by asbestos exposure. It occurs much more commonly in the chest (malignant pleural mesothelioma)

More information

Cardiac Masses and Tumors

Cardiac Masses and Tumors Cardiac Masses and Tumors Question: What is the diagnosis? A. Aortic valve myxoma B. Papillary fibroelastoma C. Vegetation from Infective endocarditis D. Thrombus in transit E. None of the above Answer:

More information

Online supplements are not copyedited prior to posting.

Online supplements are not copyedited prior to posting. Functional Impact of a Spectrum of Interstitial Lung Abnormalities in Rheumatoid Arthritis Tracy J. Doyle, MD, MPH; Paul F. Dellaripa, MD; Kerri Batra, MD; Michelle L. Frits, BA; Christine K. Iannaccone,

More information

Report of Working Groups

Report of Working Groups BD5.3 Report of Working Groups Elimination of Asbestos-related Diseases ICOH 2012 March 18, 2012 Cancun Report of WG Elimination of Asbestos-related Diseases Dr. Sherson mail to ICOH President of 7 December

More information

Defending Lung Cancer Claims A Primer for Young Lawyers

Defending Lung Cancer Claims A Primer for Young Lawyers Defending Lung Cancer Claims A Primer for Young Lawyers Michael W. Drumke Swanson, Martin & Bell, LLP 330 North Wabash Avenue, Suite 3300 Chicago, IL 60611-3604 (312) 321-9100 (312) 321-0990 mdrumke@smbtrials.com

More information

Chest Radiology 101: Back To The Basics

Chest Radiology 101: Back To The Basics Chest Radiology 101: Back To The Basics Brian Korotzer, MD Pulmonary and Critical Care Medicine Kaiser Permanente, Bellflower Associate Clinical Professor of Medicine David Geffen School of Medicine at

More information

The observations and conclusions reported here represent

The observations and conclusions reported here represent State of the Art in Clinical & Anatomic Pathology Pathology of Asbestosis An Update of the Diagnostic Criteria Report of the Asbestosis Committee of the College of American Pathologists and Pulmonary Pathology

More information

Emphysema Findings Associated with Heavy Asbestos-Exposure in High Resolution Computed Tomography of Finnish Construction Workers

Emphysema Findings Associated with Heavy Asbestos-Exposure in High Resolution Computed Tomography of Finnish Construction Workers J Occup Health 2004; 46: 266 271 Journal of Occupational Health Emphysema Findings Associated with Heavy Asbestos-Exposure in High Resolution Computed Tomography of Finnish Construction Workers Olli HUUSKONEN

More information