Optimization of nodule management in CT lung cancer screening Heuvelmans, Marjolein

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1 Optimization of nodule management in CT lung cancer screening Heuvelmans, Marjolein IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2015 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Heuvelmans, M. A. (2015). Optimization of nodule management in CT lung cancer screening [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Optimization of Nodule Management in Low-Dose CT Lung Cancer Screening

3 Marjolein A. Heuvelmans Optimization of nodule management in low-dose CT lung cancer screening PhD thesis University of Groningen, with a summary in Dutch ISBN: (printed version) ISBN: (electronic version) Copyright Marjolein Heuvelmans No part of this thesis may be reproduced, stored, or transmitted in any form or by any means, without permission from the author. Cover design and layout: Marjolein Heuvelmans Printed by: Ipskamp Drukkers Enschede B.V. The publication of this thesis was financially supported by: University of Groningen, Department of Pulmonology, University Medical Center Groningen, Guerbet, Bracco Imaging Europe B.V.

4 Optimization of Nodule Management in Low-Dose CT Lung Cancer Screening Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op maandag 21 december 2015 om uur door Marjolein Anne Heuvelmans geboren op 26 december 1988 te Schijndel

5 Promotoren Prof. dr. M. Oudkerk Prof. dr. H.J.M. Groen Prof. dr. R. Vliegenthart Beoordelingscommissie Prof. dr. H.J. de Koning Prof. dr. J.W.J. Lammers Prof. dr. J.A. Langendijk

6 Voor mijn ouders

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8 Contents I Introduction 1 1 General introduction and outline of the thesis 3 2 Contributions of the European trials (European randomized screening Group) in CT lung cancer screening 9 3 A practical approach to radiological evaluation of CT lung cancer screening examinations 25 II Quantitative: 2D/3D comparison, volumetry, and volume-doubling time 39 4 Optimization of volume-doubling time cutoff for fast-growing lung nodules in CT lung cancer screening reduces false-positive referrals 41 5 Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening 57 6 Agreement of diameter and volume measurements of pulmonary nodules found in CT lung cancer screening 85 7 Occurrence and lung cancer probability of new solid nodules at incidence CT lung cancer screening: the NELSON trial 99 8 Quantification of growth patterns of lung cancers detected in CT lung cancer screening 115 III Qualitative: CT imaging in lung cancer screening The impact of radiologists expertise on screen results decisions in a CT lung cancer screening trial 133

9 10 Features of resolving and nonresolving indeterminate pulmonary nodules at follow-up CT: The NELSON study Response: Features of resolving and nonresolving indeterminate pulmonary nodules at follow-up CT: The NELSON Study 165 IV General discussion, future perspectives, and summary General discussion Summary Nederlandse samenvatting 201 V Appendix Dankwoord Bibliography Curriculum Vitae 223

10 CONTENTS ix Abbreviations and acronyms τ 2D 3D ACCP ACR CI COPD CT DANTE DLSCT ELCAP EUCT GROWCAT HU IQR ITALUNG LDCT LUSI MDCT MILD NELSON NLST NODCAT OR PLCO PLuSS PPV PVC SA SD UKLS USPSTF VDT time constant two-dimensional three-dimensional American College of Chest Physicians American College of Radiology confidence interval chronic obstructive pulmonary disease computed tomography Detection and screening of early lung cancer by Novel imaging Technology and molecular assays Danish Lung Cancer Screening Trial Early Lung Cancer Action Project European randomized lung cancer CT screening nodule growth category Hounsfield Units inter-quartile range Italian Lung cancer Computed Tomography screening trial low-dose computed tomography German Lung Cancer Screening Intervention Study multi-detector computer tomography Multi-centre Italian Lung Detection Trial Dutch-Belgian Randomized Lung Cancer Screening Trial National Lung Screening Trial nodule size category Odds ratio Prostate, Lung Colorectal and Ovarian Cancer Screening Trial Pittsburgh Lung Screening Study positive predictive value percentage volume change semi-automated standard deviation United Kingdom Lung Cancer Screening Trial U.S. Preventive Services Task Force volume-doubling time

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12 Part I Introduction

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