Childhood onset MS and MS during Pregnancy

Size: px
Start display at page:

Download "Childhood onset MS and MS during Pregnancy"

Transcription

1 Childhood onset MS and MS during Pregnancy Rinze Frederik Neuteboom

2 -The studies in this thesis were financially supported by Stichting MS Research -Financial support for publication: Erasmus University Rotterdam, Stichting MS Research -Cover: spaceman by Lennart Nilsson, used with permission. ISBN: Layout: Print: Simone Vinke, Ridderprint B.V., Ridderkerk, The Netherlands Ridderprint B.V., Ridderkerk, The Netherlands

3 Childhood onset MS and MS during Pregnancy Debuut van MS op de kinderleeftijd en MS tijdens zwangerschap PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. H.G. Schmidt en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op donderdag 12 april 2012 om 11:30 uur door Rinze Frederik Neuteboom Geboren te Apeldoorn

4 Promotiecommissie Promotoren: Overige leden: Copromotor: Prof.dr. R.Q. Hintzen Prof.dr. J.D. Laman Prof.dr. P.A. Van Doorn Prof.dr. W.F.M. Arts Prof.dr. C.J.M. De Groot Dr. C.E. Catsman-Berrevoets

5 Table of contents Chapter 1 General introduction 7 Chapter 2 Pregnancy and multiple sclerosis 31 Chapter 2.1 Pregnancy in multiple sclerosis: clinical and self-report scales. 33 J Neurol. 2012;259: Chapter 2.2 Breast-feeding, postpartum and prepregnancy disease activity 47 in multiple sclerosis. Neurology 2011;76:1532 Chapter 2.3 First trimester interleukin 8 levels are associated with postpartum 51 relapse in multiple sclerosis. Mult Scler. 2009;15: Chapter 2.4 The monocyte transcriptome during pregnancy in multiple sclerosis: 57 prominent expression of the Fc-receptor CD64. Mult Scler. 2011;17: Chapter 2.5 Pregnancy-induced fluctuations in functional T-cell subsets in 69 multiple sclerosis patients. Mult Scler. 2010;16: Chapter 2.6 Serum leptin levels during pregnancy in multiple sclerosis. 79 Mult Scler. 2009;15: Chapter 3 Childhood onset in multiple sclerosis 91 Chapter 3.1 Prognostic factors after a first attack of inflammatory CNS 93 demyelination in children. Neurology 2008;71: Chapter 3.2 Barkhof MRI criteria predict early relapse in pediatric multiple 105 sclerosis. Pediatr Neurol. 2010;42:53-55 Chapter 3.3 A comparison of MRI criteria for diagnosing paediatric ADEM and MS. 113 Neurology 2010;74: Chapter 4 General discussion and future perspectives 121 Summary 141 Samenvatting 145 List of abbreviations 149 Dankwoord 153 Curriculum vitae 157 List of publications 159 Portfolio 163

6

7 Chapter 1 General introduction

8 Chapter 1 Special situations in MS Multiple sclerosis (MS) is a chronic, incurable disease. Currently, treatments offered to patients with MS do not substantially prevent progressive disability. The Holy Grail in MS research is to develop a definitive cure for MS or at least a method for halting disease progression. Greater knowledge about the etiology and pathogenesis is required to be able to move forward towards a better treatment. Central to this thesis is the concept that through study of natural disease course and natural modifiers, crucial lessons can be learned about etiology, pathogenesis, prognosis and perhaps ultimately new treatment options in MS. This thesis will focus on two special and different situations in MS: pregnancy and MS, and childhood onset of MS. Pregnancy strongly influences disease course in MS. The number of relapses in MS is decreased during pregnancy. However, during the first three months after delivery the number of relapses increases. Alterations in the immune system during pregnancy, essential for a successful pregnancy, likely cause this disease amelioration. Studying clinical features and immune functions during and after pregnancy in MS can provide insight into the pathogenesis of MS in general. It can also prove to be of clinical benefit to women with MS that are pregnant or have a childwish, in supplying both patients and doctors with more detailed information about disease course around pregnancy. Furthermore it may reveal possible biomarkers for predicting postpartum relapse. In a small minority of patients clinical debut of MS occurs in childhood. Diagnosis of MS in children can be difficult, because of the many diseases that can mimic MS in childhood. More information about natural disease course could therefore help to improve diagnosis and management of MS in these children. Furthermore, MS in children allows better study of potential risk factors involved in pathogenesis, that are present early in life, than is possible in patients with an adult onset. The subsequent parts of this introduction will discuss respectively in more detail: the general aspects of MS, pregnancy in MS, and childhood onset of MS. This chapter will conclude with the scope and outline of this thesis. 8

9

10 Summary Samenvatting L D list of abbreviations dankwoord Curriculum vitae L list of publications Portfolio

11 Portfolio PhD Portfolio: Summary of PhD training and teaching 1. PhD training Year Workload (ECTS) General and specific courses Biemond courses 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011 ESNI neuro-immunology course Seminars and workshops Voorjaarsvergadering NVKN 2007,2008,2009,2010,2011 Presentations MS research dagen (2 oral presentations) ECTRIMS (oral presentation) Voorjaarsvergadering NVKN (oral presentation) Wetenschappelijke vergadering NVN (oral presentation) EPNS (oral presentation) ACTRIMS/ECTRIMS/LACTRIMS ( 2 poster presentations) MS research dagen (oral presentation) ECTRIMS (poster presentation) MS research dagen (oral presentation) ECTRIMS (poster presentation) (Inter)national conferences MS research dagen 2002, 2003, 2004, 2005, 2006, 2008, 2011 ECTRIMS 2006, 2009, 2011 EPNS ACTRIMS/ECTRIMS/LACTRIMS ISPNO 2. Teaching Nascholing regionale neurologen Zuid-West Nederland Najaarsvergadering NVKN Pediatric Neurology Training for residents in pediatrics Training neuro-pediatric nurses 2010, 2011 MOLMED training 2005, 2008, Total

12

13

14

15

Students Conceptions of Constructivist Learning. Sofie Loyens

Students Conceptions of Constructivist Learning. Sofie Loyens Students Conceptions of Constructivist Learning Sofie Loyens ISBN 978-90-8559-275-4 Copyright 2007 S.M.M. Loyens All rights reserved. No part of this thesis may be reproduced or transmitted in any form,

More information

Opening the psychological black box in genetic counseling

Opening the psychological black box in genetic counseling Opening the psychological black box in genetic counseling A counselee-oriented, integrative approach on the impact of DNA-testing for breast and ovarian cancer on the lives of counselees Joël Vos 1 2 Opening

More information

The pathophysiology of necrotizing enterocolitis in preterm infants Heida, Fardou Hadewych

The pathophysiology of necrotizing enterocolitis in preterm infants Heida, Fardou Hadewych The pathophysiology of necrotizing enterocolitis in preterm infants Heida, Fardou Hadewych IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

More information

Offspring of subfertile couples: neurodevelopmental outcome at preschool age. Pamela Schendelaar

Offspring of subfertile couples: neurodevelopmental outcome at preschool age. Pamela Schendelaar Offspring of subfertile couples: neurodevelopmental outcome at preschool age Pamela Schendelaar The studies in this thesis have been carried out with financial support from the University of Groningen,

More information

M.A.Lips. Copyright 2014, M.A.Lips, Amsterdam, the Netherlands

M.A.Lips. Copyright 2014, M.A.Lips, Amsterdam, the Netherlands Roux-en-Y Gastric Bypass and Calorie Restriction: Differences and Similarities of Endocrine and Metabolic Effects in Obesity and Type 2 Diabetes Mellitus Mirjam Anne Lips Roux-en-Y Gastric Bypass and Calorie

More information

Item Analysis of Single-Peaked Response Data. The Psychometric Evaluation of Bipolar Measurement Scales

Item Analysis of Single-Peaked Response Data. The Psychometric Evaluation of Bipolar Measurement Scales Item Analysis of Single-Peaked Response Data The Psychometric Evaluation of Bipolar Measurement Scales Acknowledgement Financial support for the printing costs of this thesis was provided by the Developmental

More information

Graphical tasks to aid in diagnosing and monitoring Parkinson s disease

Graphical tasks to aid in diagnosing and monitoring Parkinson s disease Graphical tasks to aid in diagnosing and monitoring Parkinson s disease Esther J. Smits The studies described in this thesis were part of the DiPAR project for which funding was received from the EC in

More information

Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population. Carel Jan Willem Borleffs

Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population. Carel Jan Willem Borleffs Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population Carel Jan Willem Borleffs The studies described in this thesis were performed at the Department

More information

binnenzijde omslag FITNESS IN CHRONIC HEART FAILURE: EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING

binnenzijde omslag FITNESS IN CHRONIC HEART FAILURE: EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING binnenzijde omslag FITNESS IN CHRONIC HEART FAILURE: EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING FITNESS IN CHRONIC HEART FAILURE: EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING

More information

EX-POST LIABILITY RULES IN MODERN PATENT LAW. Ex-post aansprakelijkheidsregels in een modern octrooirecht

EX-POST LIABILITY RULES IN MODERN PATENT LAW. Ex-post aansprakelijkheidsregels in een modern octrooirecht EX-POST LIABILITY RULES IN MODERN PATENT LAW Ex-post aansprakelijkheidsregels in een modern octrooirecht Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag

More information

Cover Page. The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation. Author: Font Vivanco, David Title: The rebound effect through industrial ecology s eyes

More information

Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations. Nancy J. Senff

Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations. Nancy J. Senff Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Nancy J. Senff The studies described in this thesis were financially supported by a grant from the Dutch Cancer

More information

Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Author: Tabak, F.C. Title: Towards high-speed scanning tunneling microscopy Issue Date:

More information

Validation of a video game made for training laparoscopic skills Jalink, Maarten

Validation of a video game made for training laparoscopic skills Jalink, Maarten Validation of a video game made for training laparoscopic skills Jalink, Maarten IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please

More information

Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET

Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET The work described in this thesis was performed at the Department of Neurology, University Medical Center, Groningen (the Netherlands). A.T. Portman

More information

Style Characterization of Machine Printed Texts

Style Characterization of Machine Printed Texts Style Characterization of Machine Printed Texts Andrew D. Bagdanov This book is typeset by the author using L A TEX2 ε. The main body of the text is set using the Computer Modern family of fonts. The images

More information

Psychosocial and medical determinants of long-term patient outcomes

Psychosocial and medical determinants of long-term patient outcomes Psychosocial and medical determinants of long-term patient outcomes A specific focus on patients after kidney transplantation and with haemophilia Lucia Prihodova Copyright 2014 Lucia Prihodova Copyright

More information

Changes in Pilot Control Behaviour across Stewart Platform Motion Systems

Changes in Pilot Control Behaviour across Stewart Platform Motion Systems Changes in Pilot Control Behaviour across Stewart Platform Motion Systems PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus prof.

More information

Nyenrode PhD and EDP Rules and Regulations

Nyenrode PhD and EDP Rules and Regulations Nyenrode PhD and EDP Rules and Regulations SECTION 1 GENERAL PROVISIONS Article 1 Legal title Article 2 Definitions SECTION 2 REGISTRATION Article 3 Registration Article 4 Fees and expenses SECTION 3 SUPERVISION

More information

Understanding Crowd Behaviour Simulating Situated Individuals

Understanding Crowd Behaviour Simulating Situated Individuals Understanding Crowd Behaviour Simulating Situated Individuals Nanda Wijermans The research reported in this thesis was funded by the Netherlands Ministry of Defence ("DO-AIO" fund contract no TM-12). The

More information

ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS

ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS VRIJE UNIVERSITEIT ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus

More information

Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk

Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk blabla It s me Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk blabla Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector

More information

New Edge. Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN

New Edge. Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN New Edge Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN Produced by F&N Boekservice 2011, Dorien Zandbergen, Leiden, The Netherlands Front and back covers designed by Lise

More information

ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES

ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Tilburg, op gezag van de rector magnificus, prof.dr. F.A. van der Duyn Schouten,

More information

Authenticity and Architecture

Authenticity and Architecture Authenticity and Architecture Representation and Reconstruction in Context Proefschrift ter verkrijging van de graad van doctor aan Tilburg University, op gezag van de rector magnificus, prof. dr. Ph.

More information

Cover Page. The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation Author: Boekholt, Tjarda Title: Chaotic dynamics in N-body systems Issue Date: 2015-11-10

More information

The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case

The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case 2003 U 842 The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case een wetenschappelijke proeve op het gebied van de Managementwetenschappen Proefschrift ter verkrijging

More information

Implementations of tests on the exogeneity of selected. variables and their Performance in practice ACADEMISCH PROEFSCHRIFT

Implementations of tests on the exogeneity of selected. variables and their Performance in practice ACADEMISCH PROEFSCHRIFT Implementations of tests on the exogeneity of selected variables and their Performance in practice ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag

More information

Enhancing the wellbeing of older people in Mauritius

Enhancing the wellbeing of older people in Mauritius Enhancing the wellbeing of older people in Mauritius Proefschrift ter verkrijging van de graad van doctor aan Tilburg University op gezag van de rector magnificus, prof. dr. Ph. Eijlander, in het openbaar

More information

Making the title page for your dissertation a practical guide

Making the title page for your dissertation a practical guide Making the title page for your dissertation a practical guide Contents: 1. The front the basics 2. The reverse side the basics 2.1 The reverse side Adding the (co)promotor(s) and 2.2 The reverse side Adding

More information

RENSKE HOEFMAN THE IMPACT OF CAREGIVING

RENSKE HOEFMAN THE IMPACT OF CAREGIVING RENSKE HOEFMAN THE IMPACT OF CAREGIVING The Impact of Caregiving The measurement and valuation of informal care for use in economic evaluations Renske Hoefman Renske Hoefman, 2015 ISBN: 978-94-90420-56-7

More information

SAFE BUT SORRY. Theory, assesment, and treatment of pain-related fear in chronic low back pain patients

SAFE BUT SORRY. Theory, assesment, and treatment of pain-related fear in chronic low back pain patients SAFE BUT SORRY Theory, assesment, and treatment of pain-related fear in chronic low back pain patients SAFE but SORRY: Theory, assessment, and treatment of pain-related fear in chronic low back pain patients

More information

Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity

Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity Oxidative stress, neuroendocrine function and behavior in an animal model of extended longevity Alessandra Berry Alessandra Berry Oxidative stress, neuroendocrine function and behavior in an animal model

More information

Theses Books Layout Manual

Theses Books Layout Manual Theses Books Layout Manual Manual Pottenbakkerstraat 15 2984 AX Ridderkerk P.O. Box 46 2980 AA Ridderkerk T +31 (0)180 463 962 E info@ridderprint.nl I www.ridderprint.nl About Us Ridderprint is a dynamic

More information

Shop floor design: layout, investments, cross-training, and labor allocation. Jos Bokhorst

Shop floor design: layout, investments, cross-training, and labor allocation. Jos Bokhorst Shop floor design: layout, investments, cross-training, and labor allocation Jos Bokhorst Published by: Labyrint Publications Pottenbakkerstraat 15-17 2984 AX Ridderkerk The Netherlands Tel: +31 (0) 1804-63962

More information

Childhood onset MS and MS during Pregnancy

Childhood onset MS and MS during Pregnancy Childhood onset MS and MS during Pregnancy Rinze Frederik Neuteboom -The studies in this thesis were financially supported by Stichting MS Research -Financial support for publication: Erasmus University

More information

CNS immune mediated demyelinating diseases Predicting MS. Coriene Catsman-Berrevoets, paediatric neurologist

CNS immune mediated demyelinating diseases Predicting MS. Coriene Catsman-Berrevoets, paediatric neurologist CNS immune mediated demyelinating diseases Predicting MS Coriene Catsman-Berrevoets, paediatric neurologist Case 1 14 year old girl No medical history Progressive loss of vison of the left eye since 3

More information

METAPHORS OF PEACE AND VIOLENCE IN THE FOLKLORE DISCOURSES OF SOUTH WESTERN ETHIOPIA: A COMPARATIVE

METAPHORS OF PEACE AND VIOLENCE IN THE FOLKLORE DISCOURSES OF SOUTH WESTERN ETHIOPIA: A COMPARATIVE VRIJE UNIVERSITEIT METAPHORS OF PEACE AND VIOLENCE IN THE FOLKLORE DISCOURSES OF SOUTH WESTERN ETHIOPIA: A COMPARATIVE STUDY ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit

More information

ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS

ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS Publication of this thesis has been financially supported by Holec Ridderkerk, The Netherlands CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN

More information

Behavioral Corporate Governance: Four Empirical Studies. Gerwin van der Laan

Behavioral Corporate Governance: Four Empirical Studies. Gerwin van der Laan Behavioral Corporate Governance: Four Empirical Studies Gerwin van der Laan RIJKSUNIVERSITEIT GRONINGEN BEHAVIORAL CORPORATE GOVERNACE: Four Empirical Studies Proefschrift ter verkrijging van het doctoraat

More information

Essays on Applied Microeconometrics. Ruud H. Koning. To my parents

Essays on Applied Microeconometrics. Ruud H. Koning. To my parents Essays on Applied Microeconometrics Ruud H. Koning To my parents CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK DEN HAAG Koning, Rudy Hans Essays on applied microeconometrics/rudy Hans Koning - Capelle aan den IJssel:

More information

Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings

Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings RIJKSUNIVERSITEIT GRONINGEN Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings Jan Versijpt Josef Sudek ( 1896-1976) was a famous

More information

Autism s Anatomy. A dissection of the structure and development of a psychiatric concept Berend Verhoeff

Autism s Anatomy. A dissection of the structure and development of a psychiatric concept Berend Verhoeff Autism s Anatomy A dissection of the structure and development of a psychiatric concept Berend Verhoeff ISBN: 978-90-367-8160-2 2015 by Berend Verhoeff Printed and bound by Ipskamp drukkers, Amsterdam

More information

Structural performance and failure analysis of aluminium foams Amsterdam, Emiel

Structural performance and failure analysis of aluminium foams Amsterdam, Emiel Structural performance and failure analysis of aluminium foams Amsterdam, Emiel IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please

More information

Productivity costs in economic evaluations. Marieke Krol

Productivity costs in economic evaluations. Marieke Krol Productivity costs in economic evaluations Marieke Krol ISBN: 978-94-6169-327-3 Marieke Krol 2012 No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or any

More information

Why participation works

Why participation works Why participation works Full title Why participation works: the role of employee involvement in the implementation of the customer relationship management type of organizational change. Key words Participation,

More information

Strategic Interactions in Franchise Relationships. Evelien Croonen

Strategic Interactions in Franchise Relationships. Evelien Croonen Strategic Interactions in Franchise Relationships Evelien Croonen Publisher: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij Ridderprint B.V.,

More information

Small artery tone under control of the endothelium

Small artery tone under control of the endothelium Small artery tone under control of the endothelium On the importance of EDHF and myogenic tone in organ (dys)function Simone K. Gschwend Publication of this thesis was supported by generous contributions

More information

Launching Defeating MS Together The European Code of Good Practice in MS. Dr Alexis Willett & Prof Gavin Giovannoni

Launching Defeating MS Together The European Code of Good Practice in MS. Dr Alexis Willett & Prof Gavin Giovannoni Launching Defeating MS Together The European Code of Good Practice in MS Dr Alexis Willett & Prof Gavin Giovannoni Outline 1. Background 2. Activity since the original Code 3. Revision process 4. Key features

More information

Cover Page. The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation. Author: Lamberts, Agneta Luciana Matthanja (Thanja) Title: Unraveling the surface formation

More information

A Dynamic Perspective on Second Language Development. Tal Caspi

A Dynamic Perspective on Second Language Development. Tal Caspi A Dynamic Perspective on Second Language Development Tal Caspi i The work in this thesis has been carried out under the auspices of the School of Behavioral and Cognitive Neuroscience (BCN) and the Center

More information

Motor Learning in ACL Injury Prevention. Anne Benjaminse

Motor Learning in ACL Injury Prevention. Anne Benjaminse Motor Learning in ACL Injury Prevention Anne Benjaminse Anne Benjaminse Motor Learning in ACL Injury Prevention Dissertation University of Groningen, the Netherlands. With summary in Dutch. Cover by: Julia

More information

Determining the Cross-Channel Effects of Informational Web Sites. Marije L. Teerling

Determining the Cross-Channel Effects of Informational Web Sites. Marije L. Teerling Determining the Cross-Channel Effects of Informational Web Sites Marije L. Teerling Published by: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij

More information

Regulation of hepatobiliary transport function by nuclear receptors

Regulation of hepatobiliary transport function by nuclear receptors Regulation of hepatobiliary transport function by nuclear receptors Copyright 2004 T. Kok All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without

More information

PhD Regulations. enacted by order of the Doctorate Board, February 14, 2014

PhD Regulations. enacted by order of the Doctorate Board, February 14, 2014 PhD Regulations enacted by order of the Doctorate Board, February 14, 2014 3 PhD Regulations Contents I. General Provisions 5 II. The PhD candidate 6 III. The Graduate School 7 IV. The PhD thesis supervisor

More information

Instructional Strategies for Improving Self-Monitoring of Learning to Solve Problems

Instructional Strategies for Improving Self-Monitoring of Learning to Solve Problems Instructional Strategies for Improving Self-Monitoring of Learning to Solve Problems The research reported here was carried out at the In the context of the research school (Interuniversity Center for

More information

Measuring The Costs Of Chapter 11 Cases

Measuring The Costs Of Chapter 11 Cases Measuring The Costs Of Chapter 11 Cases Professional Fees in American Corporate Bankruptcy Cases Proefschrift ter verkrijging van het doctoraat in de Rechtsgeleerdheid aan de Rijksuniversiteit Groningen

More information

Workflow Support for the Healthcare Domain

Workflow Support for the Healthcare Domain Workflow Support for the Healthcare Domain register patient check patient data physical examination make documents consultation give information Ronny Mans Workflow Support for the Healthcare Domain CIP-DATA

More information

The effects of Crisis Plans for Patients with Psychotic and Bipolar disorders. Asia Ruchlewska-Winius

The effects of Crisis Plans for Patients with Psychotic and Bipolar disorders. Asia Ruchlewska-Winius The effects of Crisis Plans for Patients with Psychotic and Bipolar disorders Asia Ruchlewska-Winius The study was financially supported by The Netherlands Organization for Health Research and Development

More information

RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA

RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA Proefschrift ter verkrijging van het doctoraat in de Geneeskunde aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus

More information

Interaction Protocols in PARADIGM PROEFSCHRIFT

Interaction Protocols in PARADIGM PROEFSCHRIFT Interaction Protocols in PARADIGM Extensions to a Modeling Language through Tool Development PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus

More information

Assessing Progress in Mastery of Counseling Communication Skills. Jeroen Kuntze

Assessing Progress in Mastery of Counseling Communication Skills. Jeroen Kuntze Assessing Progress in Mastery of Counseling Communication Skills Jeroen Kuntze Coverphoto: Coverdesign: Printer: Rob de Ridder Carl Looijen Ponsen & Looijen bv, Ede 2009 Jeroen Kuntze, Rotterdam Assessing

More information

High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness

High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness RIJKSUNIVERSITEIT GRONINGEN High Performance Human Resource Management in Ireland and the Netherlands:

More information

De groepsleider als evenwichtskunstenaar

De groepsleider als evenwichtskunstenaar De groepsleider als evenwichtskunstenaar Leescommissie Prof. dr. P.H. van der Laan Prof. dr. T.V.M. Pels Prof. dr. I. Weijers Prof. dr. M. de Winter Omslagontwerp: Primo!studio Delft Foto omslag: [stockbureau

More information

A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING. Konrad Banachewicz

A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING. Konrad Banachewicz A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING Konrad Banachewicz VRIJE UNIVERSITEIT A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan

More information

Procedure for Requesting Biological Samples and Data from the Accelerated Cure Project MS Repository

Procedure for Requesting Biological Samples and Data from the Accelerated Cure Project MS Repository Procedure for Requesting Biological Samples and Data from the Accelerated Cure Project MS Repository March 2009 The Accelerated Cure Project Blood, Tissue and Data Bank solicits proposals requesting biological

More information

Cover Page. The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation. Author: Maczuga, Piotr Title: Towards RNAi based therapy of liver diseases : diversity

More information

Biodegradable plates and screws in oral and maxillofacial surgery Buijs, Gerrit Jacob

Biodegradable plates and screws in oral and maxillofacial surgery Buijs, Gerrit Jacob Biodegradable plates and screws in oral and maxillofacial surgery Buijs, Gerrit Jacob IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please

More information

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences The Nuts and Bolts of Multiple Sclerosis Rebecca Milholland, M.D., Ph.D. Center for Neurosciences Objectives Discuss which patients are at risk for Multiple Sclerosis Discuss the diagnostic criteria for

More information

Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study

Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study Compositional Changes of B and T Cell Subtypes during Fingolimod Treatment in Multiple Sclerosis Patients: A 12-Month Follow-Up Study Nele Claes 1 *; Tessa Dhaeze 1 *; Judith Fraussen PhD 1 ; Bieke Broux

More information

AUBMC Multiple Sclerosis Center

AUBMC Multiple Sclerosis Center AUBMC Multiple Sclerosis Center 1 AUBMC Multiple Sclerosis Center The vision of the American University of Beirut Medical Center (AUBMC) is to be the leading academic medical center in Lebanon and the

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. The answers will refer you back to

More information

PIET VAN DER VLIST. Synchronizing the Retail Supply Chain

PIET VAN DER VLIST. Synchronizing the Retail Supply Chain PIET VAN DER VLIST Synchronizing the Retail Supply Chain Synchronizing the Retail Supply Chain Synchronizing the Retail Supply Chain Synchroniseer de retail supply chain Proefschrift ter verkrijging van

More information

Multiple Sclerosis (MS) Aprile Royal, Novartis Pharma Canada Inc. September 21, 2011 Toronto, ON

Multiple Sclerosis (MS) Aprile Royal, Novartis Pharma Canada Inc. September 21, 2011 Toronto, ON Multiple Sclerosis (MS) Aprile Royal, Novartis Pharma Canada Inc. September 21, 2011 Toronto, ON First-line DMTs Reduce Relapse Frequency by ~30% vs. Placebo Frequency of relapse with various DMTs, based

More information

Risk sharing as a supplement to imperfect capitation in health insurance:

Risk sharing as a supplement to imperfect capitation in health insurance: Risk sharing as a supplement to imperfect capitation in health insurance: a tt-adeoff between selection and efficiency Risicodeling als aanvulling op imperfecte normuitkeringen voor ziektekostenverzekeringen:

More information

Accuracy in Space and Time: Diagnosing Multiple Sclerosis. 2012 Genzyme Corporation, a Sanofi company.

Accuracy in Space and Time: Diagnosing Multiple Sclerosis. 2012 Genzyme Corporation, a Sanofi company. Accuracy in Space and Time: Diagnosing Multiple Sclerosis 2012 Genzyme Corporation, a Sanofi company. Brought All rights to reserved. you by www.msatrium.com, MS.US.PO876.1012 your gateway to MS knowledge.

More information

Economics of Insurance against Climate Change. W.J. Wouter Botzen

Economics of Insurance against Climate Change. W.J. Wouter Botzen Economics of Insurance against Climate Change W.J. Wouter Botzen Promotor: prof. dr. J.C.J.M. van den Bergh Thesis committee: prof. dr. J.C.J.H. Aerts prof. dr. H. Kunreuther prof. dr. P. Rietveld prof.

More information

Chronic heart failure diagnostics and application of neuropeptides. in residential elderly

Chronic heart failure diagnostics and application of neuropeptides. in residential elderly Chronic heart failure diagnostics and application of neuropeptides in residential elderly Maaike Barents geboren 27 december 1950 te Utrecht Paranimfen: Els Barents Christien Enzing Barents, Maaike Chronic

More information

Conflicts over land in the Niger river delta region of Mali Kaboré, Pato Daniel

Conflicts over land in the Niger river delta region of Mali Kaboré, Pato Daniel Conflicts over land in the Niger river delta region of Mali Kaboré, Pato Daniel IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please

More information

Quantitative Approaches for Profit Maximization in Direct Marketing

Quantitative Approaches for Profit Maximization in Direct Marketing Quantitative Approaches for Profit Maximization in Direct Marketing Hiek van der Scheer To Ellen The research for this thesis was supported by: Marketing Support Group Groningen Rabofacet Its publication

More information

RELAPSE MANAGEMENT. Pauline Shaw MS Nurse Specialist 25 th June 2010

RELAPSE MANAGEMENT. Pauline Shaw MS Nurse Specialist 25 th June 2010 RELAPSE MANAGEMENT Pauline Shaw MS Nurse Specialist 25 th June 2010 AIMS OF SESSION Relapsing/Remitting MS Definition of relapse/relapse rate Relapse Management NICE Guidelines Regional Clinical Guidelines

More information

Life with MS: Mastering Early Treatment

Life with MS: Mastering Early Treatment Life with MS: Mastering Early Treatment Essential Information About MS Multiple sclerosis (MS) is a disease that attacks the central nervous system (CNS). Approximately 2.5 million people worldwide and

More information

Colliding winds in Wolf-Rayet binaries

Colliding winds in Wolf-Rayet binaries RIJKSUNIVERSITEIT GRONINGEN Colliding winds in Wolf-Rayet binaries PROEFSCHRIFT ter verkrijging van het doctoraat in de Wiskunde en Natuurwetenschappen aan de Rijksuniversiteit Groningen op gezag van de

More information

voorwerk 25-08-1999 14:03 Pagina 1

voorwerk 25-08-1999 14:03 Pagina 1 voorwerk 25-08-1999 14:03 Pagina 1 Two-handed interaction in computer supported 3D conceptual modeling voorwerk 25-08-1999 14:03 Pagina 2 ISBN 90-9013038-1 Layout: Cover: Concept: Layout and design: Computer

More information

Learning to Improve Improved Learning. Leren verbeteren, verbeterd leren

Learning to Improve Improved Learning. Leren verbeteren, verbeterd leren Learning to Improve Improved Learning Leren verbeteren, verbeterd leren Learning to Improve Improved Learning Leren verbeteren, verbeterd leren Proefschrift ter verkrijging van de graad van doctor aan

More information

Microcosting in Economic Evaluations

Microcosting in Economic Evaluations Microcosting in Economic Evaluations Issues of accuracy, feasibility, consistency and generalisability Siok Swan Tan ISBN 978-90-8559-587-8 This thesis was partly supported by GlaxoSmithKline Services

More information

Cover Page. The handle http://hdl.handle.net/1887/22736 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/22736 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/22736 holds various files of this Leiden University dissertation. Author: Kara, Firat Title: Monitoring Alzheimer's disease in transgenic mice with ultra

More information

Transcriptional regulation of central amino acid metabolism in Lactococcus lactis Larsen, Rasmus

Transcriptional regulation of central amino acid metabolism in Lactococcus lactis Larsen, Rasmus Transcriptional regulation of central amino acid metabolism in Lactococcus lactis Larsen, Rasmus IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite

More information

On Extreme Events in Banking and Finance

On Extreme Events in Banking and Finance On Extreme Events in Banking and Finance Financial Stability Risk Management Tail Risk Financial Markets Maarten R.C. van Oordt ISBN: 978-94-6108-510-8 c Maarten R.C. van Oordt 2013 c Elsevier 2012, 2013

More information

Calendar of events NEUROLOGY

Calendar of events NEUROLOGY Calendar of events 2016 NEUROLOGY Rome, Italy 29 January 2016 Updates on MS treatment management Project an individualized treatment plan in MS Explain how to manage patients day to day issues List the

More information

The ne bis in idem principle in EU law

The ne bis in idem principle in EU law The ne bis in idem principle in EU law The ne bis in idem principle in EU law A conceptual and jurisprudential analysis PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden,

More information

MULTIPLE SCLEROSIS Update. Disclosures. Multiple Sclerosis. I do not have any disclosures. E. Torage Shivapour, M.D.

MULTIPLE SCLEROSIS Update. Disclosures. Multiple Sclerosis. I do not have any disclosures. E. Torage Shivapour, M.D. MULTIPLE SCLEROSIS Update E. Torage Shivapour, M.D. Clinical Professor Department of Neurology University of Iowa Hospitals & Clinics Disclosures I do not have any disclosures. Multiple Sclerosis Most

More information

Summary chapter 2 chapter 2

Summary chapter 2 chapter 2 Summary Multiple Sclerosis (MS) is a chronic disease of the brain and the spinal cord. The cause of MS is unknown. MS usually starts in young adulthood. In the course of the disease progression of neurological

More information

acquired chronic immune-mediated inflammatory condition of CNS. MS in children: 10% +secondary progressive MS: rare +primary progressive MS: rare

acquired chronic immune-mediated inflammatory condition of CNS. MS in children: 10% +secondary progressive MS: rare +primary progressive MS: rare Immunomodulatory Therapies in Pediatric MS Vuong Chinh Quyen Neurology Department Medscape Mar 8, 2013 Multiple Sclerosis in Children. Iran J Child Neurol. 2013 Spring Introduction acquired chronic immune-mediated

More information

Modeling the Clustering of Distribution Centers around Amsterdam Airport Schiphol

Modeling the Clustering of Distribution Centers around Amsterdam Airport Schiphol Modeling the Clustering of Distribution Centers around Amsterdam Airport Schiphol location endowments, economies of agglomeration, locked-in logistics and policy implications Pim Martinus Jacobus Warffemius

More information

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate ABN Guidelines for 2007 Treatment of Multiple Sclerosis with ß-interferon and Glatiramer Acetate Published by the Association of British Neurologists Ormond House, 27 Boswell Street, London WC1N 3JZ Contents

More information

Understanding your Tecfidera treatment

Understanding your Tecfidera treatment Understanding your Tecfidera treatment Information for patients who have been prescribed treatment with Tecfidera. (dimethyl fumarate) Contents About Multiple Sclerosis (MS) What is MS? Symptoms of MS

More information

Understanding your Tecfidera treatment

Understanding your Tecfidera treatment Understanding your Tecfidera treatment Information for patients who have been prescribed treatment with Tecfidera. (dimethyl fumarate) Contents About Multiple Sclerosis (MS) What is MS? Symptoms of MS

More information

Sex Differences in Multiple Sclerosis: Clinical, Imaging, and Pathology

Sex Differences in Multiple Sclerosis: Clinical, Imaging, and Pathology Sex Differences in Multiple Sclerosis: Clinical, Imaging, and Pathology Sex Differences and Implications for Translational Neuroscience Research A Workshop Forum on Neuroscience and Nervous System Disorders

More information

Beam Orientation Selection in Radiotherapy Treatment Planning

Beam Orientation Selection in Radiotherapy Treatment Planning Beam Orientation Selection in Radiotherapy Treatment Planning ISBN: 90-8559-199-6 Druk: Optima Rotterdam Copyright: 2000 IOP Publishing Ltd. (chapter 2) Copyright: 2003 Elsevier Inc. (chapter 3) Copyright:

More information