Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations. Nancy J. Senff

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1 Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Nancy J. Senff

2 The studies described in this thesis were financially supported by a grant from the Dutch Cancer Society (UL ) (Chapters 2 and 3). Publication of this thesis was financially supported by: Cephalon B.V., Astellas B.V., Fagron B.V., Beiersdorf NV, Merck Serono B.V., Jansen- Cilag B.V., LEO Pharma B.V., ABBOTT B.V., Bauerfeind Benelux B.V., Galderma en Wyeth Pharmaceuticals B.V. Cover design: Patrick Maidman Printed by PrintPartners Ipskamp Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Copyright 2009, Nancy Johanna Senff, The Netherlands No part of this thesis may be reproduced, stored or transmitted without prior permission of the author.

3 Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op donderdag 12 februari 2009 klokke uur door Nancy Johanna Senff geboren te Arnhem in 1977

4 Promotiecommissie Promotor: Co-promotores: Referent: Overige leden: Prof. Dr. R. Willemze Dr. C.P. Tensen Dr. M.H. Vermeer Prof. Dr. J.H.J.M. van Krieken, Radboud Universiteit, Nijmegen Prof. Dr. C.J.L.M. Meijer, Vrije Universiteit, Amsterdam Prof. Dr. E.M. Noordijk Prof. Dr. R. Willemze Dr. P.M. Jansen

5 C est le temps que tu as perdu pour ta rose qui fait ta rose si importante. Uit: Le petit prince Antoine de Saint-Exupéry ( ) Voor Philippe

6

7 Contents List of abbreviations 9 Chapter 1 General Introduction 11 Chapter 2 Reclassification of 300 primary cutaneous B-cell 31 lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers Journal of Clinical Oncology 2007; 25(12): Chapter 3 Fine-mapping chromosomal loss at 9p21: correlation with 47 prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type Journal of Investigative Dermatology; in press Chapter 4 The applicability and prognostic value of the new TNM 63 classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: results on a large cohort of primary cutaneous B-cell lymphomas and comparison with the system used by the Dutch Cutaneous Lymphoma Group British Journal of Dermatology 2007; 157(6): Chapter 5 Results of bone marrow examination in 275 patients with 75 histological features that suggest an indolent type of cutaneous B-cell lymphoma British Journal of Haematology 2008; 142(1):52-6 Chapter 6 Results of radiotherapy in 153 primary cutaneous B-cell 87 lymphomas classified according to the WHO-EORTC classification Archives of Dermatology 2007; 143(12):1520-6

8 Chapter 7 European Organization for Research and Treatment of 101 Cancer (EORTC) and International Society for Cutaneous Lymphoma (ISCL) consensus recommendations for the management of cutaneous B-cell lymphomas Blood 2008; 112(5): Chapter 8 Summary and Discussion 131 Nederlandse samenvatting 147 List of publications 153 Curriculum vitae 157 Nawoord 161

9 List of abbreviations ABC Activated B-cell acgh Array-based comparative genomic hybridization Bcl-2 B-cell CLL/lymphoma 2 BMB Bone marrow biopsy CBCL Primary cutaneous B-cell lymphoma cfcl Cutaneous follicle centre lymphoma CTCL Primary cutaneous T-cell lymphoma DCLG Dutch Cutaneous Lymphoma Group DLBCL Diffuse large B-cell lymphoma DSS Disease-specific survival EMZL Extranodal marginal zone lymphoma EORTC(-CLG) European Organization for Research and Treatment of Cancer ( Cutaneous Lymphoma Group) FL Follicular lymphoma FOXP1 Forkhead box P1 GCB Germinal centre B-cell ISCL International Society for Cutaneous Lymphomas MF Mycosis fungoides MLPA Multiplex Ligation-dependent Probe Amplification MUM-1 Multiple myeloma oncogene 1 NHL Non-Hodgkin lymphoma OS Overall survival PCFCCL Primary cutaneous follicle centre cell lymphoma PCFCL Primary cutaneous follicle centre lymphoma PCI Primary cutaneous immunocytoma PCLBCL-leg Primary cutaneous large B-cell lymphoma of the leg PCLBCL, LT Primary cutaneous diffuse large B-cell lymphoma, leg type PCLBCL, other Primary cutaneous diffuse large B-cell lymphoma, other PCMZL Primary cutaneous marginal zone B-cell lymphoma RFS Relapse-free survival RT Radiotherapy SS Sézary syndrome WHO World Health Organization 9

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