CURRICULUM VITAE. Research Interest: Bresat Cancer, Gyneocologic Cancer, Colorectal Cancer, Lung Cancer.

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1 CURRICULUM VITAE Personal Details Surname: KARAOGLU First Name: Aziz Akademic title/ position: Asscociate Proffessor Key Qualifications: -Internal Medicine, -Medical Oncology Research Interest: Bresat Cancer, Gyneocologic Cancer, Colorectal Cancer, Lung Cancer. International Experience/Collaborations: - Contact Details: Work Address: Firat University, Medical School, Medical Oncology Department Name of Hospital: Firat University Hospital Street:... Town: ElAZIG Country: Turkey Post Code:... Phone/Fax: / azizk6@yahoo.com Date of Birth: Place and Country of Birth: IZMIR, TURKEY Country of Citizenship: Republic of Türkiye Country of Training: Türkiye First Language: Turkish Languages: English

2 Akademic Details Faculty/University ( name and address) Date of Graduation: 1990 Medical School / Firat University Postgraduate Training: ( Name and address of Center and Supervisor [s] in charge of Training) 1-Training of Internal Medicine Firat University Medical School Department of Internal Medicine ELAZIG 2-Training of Medical Oncology Hacettepe University Institute of Oncology Ankara, Turkey SUPERVISOR IN CHARGE OF TRAINING: From To 1-Training of Internal Medicine : Training of Medical Oncology: Title of thesis: 1. Effectiveness of Intravenous Omeprazole and Ranitidine For Gastrointestinal Bleedings of Acid-Peptic Disease 2. The prognostic significance of cyclin D1, p27, and cyclin E and their correlations wih other prognostic factors in stage III epithelial ovarian carcinoma Accreditation: Government body (Name, number and date of certificate issued by Universty, Medical Association or Government Body) Academic Experience: Associate Professor Memberships: 1-European Society for Medical Oncology 2-Anatolian Society for Medical Oncology (Turkey) 3-Society for Oncology Group (Turkey)

3 4-Society for Medical Oncology (Turkey) 5-Society for Internal Medicine (Turkey) 6-Society for Firat University Internal Medicine International Publications 1. Karaoglu A, Aydin S, Dagli AF, Cummings DE, Ozercan IH, Canatan H, Ozkan Y. Expression of obestatin and ghrelin in papillary thyroid carcinoma. Mol Cell Biochem Nov 28. [Epub ahead of print] 2. Dagli AF, Aydin S, Karaoglu A, Akpolat N, Ozercan IH, Ozercan MRGhrelin expression in normal kidney tissue and renal carcinomas. Pathol Res Pract Dec 1. [Epub ahead of print] 3. Topkan E, Polat Y, Karaoglu A. Primary mucinous adenocarcinoma of appendix treated with chemotherapy and radiotherapy: a case report. Tumori, 94, (2008). 4. Alacacioglu A, Somali I, Simsek I, Astarcioglu I, Ozkan M, Camci C, Alkis N, Karaoglu A, Tarhan O, Unek T, Yilmaz U. Epidemiology and Survival of Hepatocellular Carcinoma in Turkey: Outcome of Multicenter Study. Jpn J Clin Oncol Aug Celik H, Gurates B, Karaoğlu A, Yavuz A, Dagli F, Ozercan R. Uterine primitive neuroectodermal tumor: a case report. Arch Gynecol Obstet Jun 4. [Epub ahead of print] 6. Topkan E, Karaoglu A. Urine calcium and deoxypyridinoline in assessment of response to local radiation therapy for metastatic bone disease. J Exp Clin Cancer Res. 26(4):553-9 (2007.) 7. Topkan E, Karaoglu A. Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. Oncology. 2006;71(5-6): Aydin S, Geckil H, Karaoglu A, Elkiran ET. Med Hypotheses. 2007;69(5): Ghrelin: a novel peptide with therapeutic effect in certain cancers? 9. Elkiran ET, Mar N, Aygen B, Gursu F, Karaoglu A, Koca S. Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population. BMC Cancer. 15;7:48 (2007) 10. Balci TA, Ciftci I, Karaoglu A. Incidental DTPA and DMSA uptake during renal scanning in unknown bone metastases. Ann Nucl Med. 20(5):365-9, (2006)

4 11. Elkıran E, Aygen B, Karaoğlu A, Altundag K. Metastatic Osteosarcoma to The Brain in Adult Patient. J Neurooncol. 76(2):213 (2006) Erma M, Baltalı E., Karaoğlu A, Abali H, Engin H, Ozisik Y, Guler N, Altundag K, Atahan IL, Sayek I, Tekuzman G. A Phase II Study on The Safety and Efficacy Of 5- Fluorouracil, Epirubicin, Cyclophoshpamide (FEC) Followed By Paclitaxel In The Adjuvant Treatment Of Breast Cancer. Cancer Invest 23 (3): (2005). 13. Atessahin A, Yilmaz S, Karahan I, Ceribasi AO, Karaoglu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology 212: (2005). 14. Nazıroğlu M, Karaoğlu A, Aksoy AO. Selenium and high dose vitamin E adminstration protects cisplatin-induced oxidative damage on renal, liver, and lens tissues in rats, Toxicology, 195, (2004). 15. Karaoğlu A, Yalcin S, Tekzuman G, Kars A, Çelik I, Güler N, Özışık Y, Türker A, Barışta Đ, Güllü Đ. Weekly irinotecan in patients with metastatic colorectal cancer failing 5- Fluorouracil-based chemotherapy : Efficacy and Prognostic Factors. Tumori, 89, (2003). 16. Karaoğlu A, Altundağ K, Erman M, Engin H, Güllü Đ. Familial asynchronous bilateral primary male breast carcinoma. J Exp. Clin Cancer Res, 21, (2002). 17. Erman M, Karaoğlu A, Öksüzoglu B, Aydingöz U, Ayhan A, Güler N. Solitary esophageal metastases of breast cancer after 11 years : a case report. Med Oncol, 19, (2002). 18. Engin H, Abalı H, Erman M, Karaoğlu A, Çelik Đ, Güler N. Central nervous system sleeding as a first manifestation of immun thrombocytopenic purpura in hodgkin disease. Haematologia (Budap), 31, (2002).

5 Presentations at International Scientific Meetings: 1. Balcı TA, Ciftci I, Karaoglu A. An Unusual Tumor Of The Renal Pelvis : Primary Mucinous Adenocarcinoma. A Case Report. XXIII. World Congress Of Pathology And Laboratory Medicine. May 26 th -30 th 2005 Istanbul-Turkey. 2- Elkiran T, Celebi S, Aygen B, Karaoglu A, Ozercan I. Primary Malignant Melanoma Of Esophagogastric Junction : A Case Report. XXIII. World Congress Of Pathology And Laboratory Medicine. May 26 th -30 th 2005 Istanbul-Turkey. 3-Aygen B, Elkiran T, Karaoglu A, Akpolat A. An Unusual Tumor Of The Renal Pelvis : Primary Mucinous Adenocarcinoma. A Case Report. XXIII. World Congress Of Pathology And Laboratory Medicine. May 26 th -30 th 2005 Istanbul-Turkey 3- Karaoğlu A, Güler N, Doğan I, Ayhan A, Erman M, Öksüzoğlu B, Çelik Đ, Karaağaoğlu E, Ayhan A. The prognostic significance of cyclin D1, p27, and cyclin E and their correlations wih other prognostic factors in stage III epithelial ovarian carcinoma. 27 th ESMO Congress, October, Nice, Annal Oncol, Vol 13, 111, Karaoğlu A, Yalcin S, Tekuzman G, Erman M, Altundağ O, Oksuzoglu B, Engin H, Altundag K, Guler N. A phase II Study of weekly irinotecan in patients with metastatic colorectal cancer refractory to 5- FU based chemotherapy, American Society of Clinical Oncology, Thirty-Seventh Annual Meeting., May 12-15, Öksüzoglu B, Güler N, Engin H, Karaoğlu A, Baltalı E, Tekzuman G. Intraductal Carcinoma Patients. The Breast Journal, Vol 7, , 2001, 6-. Karaoğlu A, Yalcin S, Tekuzman G, Erman M, Altundağ O, Oksuzoglu B, Engin H, Altundag K, Guler N. A phase II Study of weekly irinotecan in patients with metastatic colorectal cancer refractory to 5- FU based chemotherapy. American Society of Clinical Oncology, Thirty-Seventh Annual Meeting., May 12-15, Öksüzoğlu B, Güler N, Engin H, Baltalı E, Karaoğlu A, Altundağ K, Altundağ Ö, Erman E, Özısık Y, Altundağ K. Salvage ifosfamide-etoposide combination after antracycline and taxane failure in advanced breast cancer patents. 11. International Congress on Anti-Cancer Treatment, February 6th to 9th, Paris-France, Karaoğlu A, Baltali E, Engin H, Erman M, Öksüzoğlu B, Altundağ Ö, Altundağ K, Özısık Y, Güler N, Tekzuman G. Combination of docetaxel, epirubicin, cyclophosphamide chemotherapy in metastatic breast cancer. 11. International Congress on Anti-Cancer Treatment, February 6th to 9th, Paris-France, Engin H, Üner A, Öksüzoğlu B, Karaoğlu A, Altundağ K, Tekzuman G. Lymphoblastic leukemia/lymphoma in adults. A clinicopathological study of 28 cases treated at the Hacettepe University Oncology Institute. 11. International Congress on Anti-Cancer Treatment. February 6th to 9th, Paris-France, 2001

6 10. Erman M, Baltali E, Engin H, Karaoğlu A, Özısık Y, Güler N, Altundağ K, Atahan L, Sayek Đ, Tekzuman G. FEC followed by paclitaxel in the adjuvant treatment of high-risk breast cancer: preliminary report. Adjuvant Therapy of Primary Breast cancer, 7th International Conference February St Gallen/Switzerland, Abali H, Karaoğlu A, Tekzuman G, Koc Y, Kansu E. IIVP regimen for salvage therapy in patients with relapsed lymphoma prior to autologous stem cell transplantation. American Society of Hematology, Forty-third Annual Meeting, December, Orlanda-Florida, Baydas G, Dönder E, Erçel E, Karaoğlu A, Yılmaz O, Çelik S. Effects of daily vitamin E supplementation on oxidative status and fatty acid composition in rats with diabetes mellitus induced with streptozotocin. 19 th Conference Of European Comparative Endocrinologists, Nijmegen, 1998.