Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer van der Gun, Bernardina, Theresia, Francisca
|
|
|
- Barry Thomas
- 7 years ago
- Views:
Transcription
1 Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer van der Gun, Bernardina, Theresia, Francisca IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2010 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Gun, B. T. F. V. D. (2010). Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer Ieneke van der Gun
3 The research presented in this thesis was financially supported by grants from the European Commission s Fifth and Sixth Framework Program (Contract QRLT and COOP-CT ). The author gratefully acknowledges the financial support for printing of this thesis by: Cover: Immunofluorescence staining for EpCAM on ovarian cancer cells Coverdesign: Peter van der Sijde, B.T.F. van der Gun Lay-out: Peter van der Sijde, Groningen Printed by: Drukkerij van Denderen, Groningen ISBN: (printed version) ISBN: (digital version) 2010, B.T.F. van der Gun No parts of this thesis may be reproduced or transmitted in any forms or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system, without permission of the author and the publisher holding the copyrights of the articles.
4 RIJKSUNIVERSITEIT GRONINGEN Regulation and epigenetic modulation of EpCAM gene expression in ovarian cancer Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 13 september 2010 om uur door Bernardina Theresia Francisca van der Gun geboren op 12 juli 1960 te Schalkwijk
5 Promotores: Copromotores: Beoordelingscommissie: Prof. dr. M.G. Rots Prof. dr. L.F.M.H. de Leij Dr. P.M.J. McLaughlin Dr. M.H.J. Ruiters Prof. dr. A. Kiss Prof. dr. H.J. Haisma Prof. dr. H. Hollema
6 Paranimfen: Alice Arendzen Margo Takke
7
8 CONTENTS Chapter 1 General introduction to the thesis 9 Chapter 2 EpCAM in carcinogenesis: the Good, the Bad or the Ugly 17 Chapter 3 Transcription factors and molecular epigenetic marks associated with 39 the EpCAM gene in ovarian cancer Chapter 4 Serum insensitive, intranuclear protein delivery by the multipurpose 57 cationic lipid Saint-2 J Control Release 2007;123(3) Chapter 5 Persistent down-regulation of the pancarcinoma-associated Epithelial 77 Cell adhesion Molecule via active intranuclear methylation Int J Cancer 2008;123(2) Chapter 6 Targeted DNA methylation by a DNA methyltransferase coupled to a 91 Triple helix Forming Oligonucleotide to downregulate the Epithelial Cell Adhesion Molecule Bioconjugate Chem. 2010; in press Chapter 7 Sustained downregulation of EpCAM gene expression by sirna 105 targeting a coding region Chapter 8 Summary & General discussion and perspectives 117 Nederlandse samenvatting 129 Dankwoord 137 Publications 141
9
Understanding Crowd Behaviour Simulating Situated Individuals
Understanding Crowd Behaviour Simulating Situated Individuals Nanda Wijermans The research reported in this thesis was funded by the Netherlands Ministry of Defence ("DO-AIO" fund contract no TM-12). The
Small artery tone under control of the endothelium
Small artery tone under control of the endothelium On the importance of EDHF and myogenic tone in organ (dys)function Simone K. Gschwend Publication of this thesis was supported by generous contributions
Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET
Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET The work described in this thesis was performed at the Department of Neurology, University Medical Center, Groningen (the Netherlands). A.T. Portman
Shop floor design: layout, investments, cross-training, and labor allocation. Jos Bokhorst
Shop floor design: layout, investments, cross-training, and labor allocation Jos Bokhorst Published by: Labyrint Publications Pottenbakkerstraat 15-17 2984 AX Ridderkerk The Netherlands Tel: +31 (0) 1804-63962
Measuring The Costs Of Chapter 11 Cases
Measuring The Costs Of Chapter 11 Cases Professional Fees in American Corporate Bankruptcy Cases Proefschrift ter verkrijging van het doctoraat in de Rechtsgeleerdheid aan de Rijksuniversiteit Groningen
Regulation of hepatobiliary transport function by nuclear receptors
Regulation of hepatobiliary transport function by nuclear receptors Copyright 2004 T. Kok All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without
Opening the psychological black box in genetic counseling
Opening the psychological black box in genetic counseling A counselee-oriented, integrative approach on the impact of DNA-testing for breast and ovarian cancer on the lives of counselees Joël Vos 1 2 Opening
Why participation works
Why participation works Full title Why participation works: the role of employee involvement in the implementation of the customer relationship management type of organizational change. Key words Participation,
RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA
RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA Proefschrift ter verkrijging van het doctoraat in de Geneeskunde aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus
Strategic Interactions in Franchise Relationships. Evelien Croonen
Strategic Interactions in Franchise Relationships Evelien Croonen Publisher: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij Ridderprint B.V.,
Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings
RIJKSUNIVERSITEIT GRONINGEN Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings Jan Versijpt Josef Sudek ( 1896-1976) was a famous
Psychosocial and medical determinants of long-term patient outcomes
Psychosocial and medical determinants of long-term patient outcomes A specific focus on patients after kidney transplantation and with haemophilia Lucia Prihodova Copyright 2014 Lucia Prihodova Copyright
ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS
VRIJE UNIVERSITEIT ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness
High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness RIJKSUNIVERSITEIT GRONINGEN High Performance Human Resource Management in Ireland and the Netherlands:
Behavioral Corporate Governance: Four Empirical Studies. Gerwin van der Laan
Behavioral Corporate Governance: Four Empirical Studies Gerwin van der Laan RIJKSUNIVERSITEIT GRONINGEN BEHAVIORAL CORPORATE GOVERNACE: Four Empirical Studies Proefschrift ter verkrijging van het doctoraat
Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk
blabla It s me Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk blabla Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector
Style Characterization of Machine Printed Texts
Style Characterization of Machine Printed Texts Andrew D. Bagdanov This book is typeset by the author using L A TEX2 ε. The main body of the text is set using the Computer Modern family of fonts. The images
M.A.Lips. Copyright 2014, M.A.Lips, Amsterdam, the Netherlands
Roux-en-Y Gastric Bypass and Calorie Restriction: Differences and Similarities of Endocrine and Metabolic Effects in Obesity and Type 2 Diabetes Mellitus Mirjam Anne Lips Roux-en-Y Gastric Bypass and Calorie
Perceived Health Status after Kidney Transplantation. Jaroslav Rosenberger
Perceived Health Status after Kidney Transplantation Jaroslav Rosenberger J. Rosenberger 2006 Oxford University Press (Chapter 3) Blackwell Publishing (Chapter 4 and 5) Lippincott Williams & Wilkins (Chapter
Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Author: Tabak, F.C. Title: Towards high-speed scanning tunneling microscopy Issue Date:
Item Analysis of Single-Peaked Response Data. The Psychometric Evaluation of Bipolar Measurement Scales
Item Analysis of Single-Peaked Response Data The Psychometric Evaluation of Bipolar Measurement Scales Acknowledgement Financial support for the printing costs of this thesis was provided by the Developmental
Graphical tasks to aid in diagnosing and monitoring Parkinson s disease
Graphical tasks to aid in diagnosing and monitoring Parkinson s disease Esther J. Smits The studies described in this thesis were part of the DiPAR project for which funding was received from the EC in
Determining the Cross-Channel Effects of Informational Web Sites. Marije L. Teerling
Determining the Cross-Channel Effects of Informational Web Sites Marije L. Teerling Published by: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij
Tasks, hierarchies, and flexibility
Tasks, hierarchies, and flexibility Planning in Food Processing Industries Wout van Wezel Uitgever: Labyrint Publication Postbus 662 2900 AR Capelle a/d IJssel Nederland Drukwerk: ISBN 90-72591-98-4 2001,
Changes in Pilot Control Behaviour across Stewart Platform Motion Systems
Changes in Pilot Control Behaviour across Stewart Platform Motion Systems PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus prof.
Cover Page. The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation. Author: Font Vivanco, David Title: The rebound effect through industrial ecology s eyes
ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES
ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Tilburg, op gezag van de rector magnificus, prof.dr. F.A. van der Duyn Schouten,
Making the title page for your dissertation a practical guide
Making the title page for your dissertation a practical guide Contents: 1. The front the basics 2. The reverse side the basics 2.1 The reverse side Adding the (co)promotor(s) and 2.2 The reverse side Adding
Linking the Customer Purchase Process to Website Development and E-commerce Performance. Adriana C. Krawczyk
Linking the Customer Purchase Process to Website Development and E-commerce Performance Adriana C. Krawczyk Published by: SOM Research School University of Groningen PO Box 800 9700 AV Groningen The Netherlands
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population. Carel Jan Willem Borleffs
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population Carel Jan Willem Borleffs The studies described in this thesis were performed at the Department
Implementations of tests on the exogeneity of selected. variables and their Performance in practice ACADEMISCH PROEFSCHRIFT
Implementations of tests on the exogeneity of selected variables and their Performance in practice ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag
Cover Page. The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation Author: Boekholt, Tjarda Title: Chaotic dynamics in N-body systems Issue Date: 2015-11-10
The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case
2003 U 842 The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case een wetenschappelijke proeve op het gebied van de Managementwetenschappen Proefschrift ter verkrijging
Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations. Nancy J. Senff
Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Nancy J. Senff The studies described in this thesis were financially supported by a grant from the Dutch Cancer
Enhancing the wellbeing of older people in Mauritius
Enhancing the wellbeing of older people in Mauritius Proefschrift ter verkrijging van de graad van doctor aan Tilburg University op gezag van de rector magnificus, prof. dr. Ph. Eijlander, in het openbaar
Photorefractivity in polymers
Photorefractivity in polymers George G. Malliaras Photorefractivity in Polymers George G. Malliaras Ph.D. Thesis University of Groningen, The Netherlands November 1995 ISBN 90-367-0569-x RIJKSUNIVERSITEIT
Authenticity and Architecture
Authenticity and Architecture Representation and Reconstruction in Context Proefschrift ter verkrijging van de graad van doctor aan Tilburg University, op gezag van de rector magnificus, prof. dr. Ph.
Financial support for the printing of the thesis was kindly provided by:
The studies described in this thesis were performed at the: Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, The Netherlands and Departments of Oncology and
ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS
ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS Publication of this thesis has been financially supported by Holec Ridderkerk, The Netherlands CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN
SAFE BUT SORRY. Theory, assesment, and treatment of pain-related fear in chronic low back pain patients
SAFE BUT SORRY Theory, assesment, and treatment of pain-related fear in chronic low back pain patients SAFE but SORRY: Theory, assessment, and treatment of pain-related fear in chronic low back pain patients
Economics of Insurance against Climate Change. W.J. Wouter Botzen
Economics of Insurance against Climate Change W.J. Wouter Botzen Promotor: prof. dr. J.C.J.M. van den Bergh Thesis committee: prof. dr. J.C.J.H. Aerts prof. dr. H. Kunreuther prof. dr. P. Rietveld prof.
A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING. Konrad Banachewicz
A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING Konrad Banachewicz VRIJE UNIVERSITEIT A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan
RIJKSUNIVERSITEIT GRONINGEN EXPORT NETWORKING CHALLENGES AND OPPORTUNITIES FOR MANUFACTURING FIRMS FROM DEVELOPING COUNTRIES: THE CASE OF ERITREA
RIJKSUNIVERSITEIT GRONINGEN EXPORT NETWORKING CHALLENGES AND OPPORTUNITIES FOR MANUFACTURING FIRMS FROM DEVELOPING COUNTRIES: THE CASE OF ERITREA Proefschrift ter verkrijging van het doctoraat in de Bedrijfskunde
Childhood onset MS and MS during Pregnancy
Childhood onset MS and MS during Pregnancy Rinze Frederik Neuteboom -The studies in this thesis were financially supported by Stichting MS Research -Financial support for publication: Erasmus University
The impact of emotional and cognitive changes after stroke
The impact of emotional and cognitive changes after stroke a longitudinal community-based study Annemarie C. Visser-Keizer The research described in this thesis was financially supported by the Netherlands
EX-POST LIABILITY RULES IN MODERN PATENT LAW. Ex-post aansprakelijkheidsregels in een modern octrooirecht
EX-POST LIABILITY RULES IN MODERN PATENT LAW Ex-post aansprakelijkheidsregels in een modern octrooirecht Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag
New Edge. Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN
New Edge Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN Produced by F&N Boekservice 2011, Dorien Zandbergen, Leiden, The Netherlands Front and back covers designed by Lise
Cover Page. The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation. Author: Maczuga, Piotr Title: Towards RNAi based therapy of liver diseases : diversity
Students Conceptions of Constructivist Learning. Sofie Loyens
Students Conceptions of Constructivist Learning Sofie Loyens ISBN 978-90-8559-275-4 Copyright 2007 S.M.M. Loyens All rights reserved. No part of this thesis may be reproduced or transmitted in any form,
Rapid user interface development with the script language Gist
RAPID USER INTERFACE DEVELOPMENT WITH THE SCRIPT LANGUAGE GIST G Groningen Dissertations in Linguistics 8 ISSN 0928{0030 Rksuniversiteit Groningen Rapid user interface development with the script language
Cover Page. The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation. Author: Lamberts, Agneta Luciana Matthanja (Thanja) Title: Unraveling the surface formation
PhD Regulations. enacted by order of the Doctorate Board, February 14, 2014
PhD Regulations enacted by order of the Doctorate Board, February 14, 2014 3 PhD Regulations Contents I. General Provisions 5 II. The PhD candidate 6 III. The Graduate School 7 IV. The PhD thesis supervisor
Nyenrode PhD and EDP Rules and Regulations
Nyenrode PhD and EDP Rules and Regulations SECTION 1 GENERAL PROVISIONS Article 1 Legal title Article 2 Definitions SECTION 2 REGISTRATION Article 3 Registration Article 4 Fees and expenses SECTION 3 SUPERVISION
Motor Learning in ACL Injury Prevention. Anne Benjaminse
Motor Learning in ACL Injury Prevention Anne Benjaminse Anne Benjaminse Motor Learning in ACL Injury Prevention Dissertation University of Groningen, the Netherlands. With summary in Dutch. Cover by: Julia
Asset information for FMEA-based maintenance. Jan Braaksma
Asset information for FMEA-based maintenance Jan Braaksma Published by: University of Groningen Groningen The Netherlands Printed by: Ipskamp Drukkers B.V. ISBN: 978-90-367-5806-2 (book) 978-90-367-5807-9
The Routed Inventory Pooling Problem. Harmen W. Bouma
The Routed Inventory Pooling Problem Harmen W. Bouma Publisher: University of Groningen Groningen The Netherlands Printed by: Ipskamp Drukkers B.V. ISBN: 978-90-367-6593-0 978-90-367-6594-7 (e-book) 203
De groepsleider als evenwichtskunstenaar
De groepsleider als evenwichtskunstenaar Leescommissie Prof. dr. P.H. van der Laan Prof. dr. T.V.M. Pels Prof. dr. I. Weijers Prof. dr. M. de Winter Omslagontwerp: Primo!studio Delft Foto omslag: [stockbureau
voorwerk 25-08-1999 14:03 Pagina 1
voorwerk 25-08-1999 14:03 Pagina 1 Two-handed interaction in computer supported 3D conceptual modeling voorwerk 25-08-1999 14:03 Pagina 2 ISBN 90-9013038-1 Layout: Cover: Concept: Layout and design: Computer
Common Focus Point Technology
Common Focus Point Technology Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus, Prof. dr. ir. J. Blaauwendraad in het openbaar
LEERSTIJLEN EN STUREN VAN LEERPROCESSEN IN HET HOGER ONDERWIJS. Naar procesgerichte instructie in zelfstandig denken
LEERSTIJLEN EN STUREN VAN LEERPROCESSEN IN HET HOGER ONDERWIJS Naar procesgerichte instructie in zelfstandig denken PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Katholieke Universiteit Brabant,
The Historical Evolution of Inequality in Latin America
The Historical Evolution of Inequality in Latin America A comparative analysis, 1870-2000 Ewout Frankema Publisher: Ewout Frankema Printed by: PrintPartners Ipskamp, Nederland. ISBN: 978-90-78249-08-5
Auto-Erecting Virtual Office Walls
Auto-Erecting Virtual Office Walls Constructing a Virtual Offi ce for Global Software Engineers Ben van Gameren Auto-Erecting Virtual Office Walls Constructing a Virtual Office for Global Software Engineers
Facilitating Reflective Learning
Facilitating Reflective Learning Mirabelle Schaub-de Jong Facilitating Reflective Learning Mirabelle Schaub-de Jong Juli 2012 1 Facilitating Reflective Learning Dissertation for the University of Groningen,
Chronic heart failure diagnostics and application of neuropeptides. in residential elderly
Chronic heart failure diagnostics and application of neuropeptides in residential elderly Maaike Barents geboren 27 december 1950 te Utrecht Paranimfen: Els Barents Christien Enzing Barents, Maaike Chronic
The assessment of efforts to return to work
The assessment of efforts to return to work Anna Muijzer Acknowledgements This study was financially supported by: - Stichting Instituut Gak, Hilversum - University Medical Center Groningen, University
Mirjam A.A. Huis in t Veld
E-MAGINE An Evaluation Method to Assess Groupware In Use Mirjam A.A. Huis in t Veld Waar mensen centraal staan, kan ICT verbinden. E-MAGINE An Evaluation Method to Assess Groupware In Use PROEFSCHRIFT
Asset Liability Management for Pension Funds using Multistage Mixed-integer Stochastic Programming
Asset Liability Management for Pension Funds using Multistage Mixed-integer Stochastic Programming Sibrand Drijver To Barbara Published by : Labyrint Publications Pottenbakkerstraat 15-17 2984 AX Ridderkerk
Appendix 2 Molecular Biology Core Curriculum. Websites and Other Resources
Appendix 2 Molecular Biology Core Curriculum Websites and Other Resources Chapter 1 - The Molecular Basis of Cancer 1. Inside Cancer http://www.insidecancer.org/ From the Dolan DNA Learning Center Cold
DETAINED ABROAD. Assisting Dutch nationals in foreign detention. Femke Hofstee-van der Meulen
DETAINED ABROAD Assisting Dutch nationals in foreign detention Femke Hofstee-van der Meulen Detained abroad - Assisting Dutch nationals in foreign detention Femke B.A.M. Hofstee-van der Meulen ISBN: 978-94-6295-410-6
Prosodic Processes in Language and Music. Maartje Schreuder
Prosodic Processes in Language and Music Maartje Schreuder Copyright 2006 by Maartje Schreuder Cover design: Hanna van der Haar Printed by Print Partners Ipskamp, Enschede The work in this thesis has been
How To Design A Network Management System
Network Management Architectures Aiko Pras CTIT Ph. D-thesis series No. 95-02 P.O. Box 217-7500 AE Enschede - The Netherlands telephone +31-53-893779 / fax +31-53-333815 Centre for Telematics and Information
Design of a. Period Batch Control. Planning System. for. Cellular Manufacturing. Jan Riezebos
Design of a Period Batch Control Planning System for Cellular Manufacturing Jan Riezebos CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAAG Riezebos, Jan The design of a period batch control planning system
TREATING PLANNING FLAWS IN PATIENT FLOWS. Justin Drupsteen
TREATING PLANNING FLAWS IN PATIENT FLOWS Justin Drupsteen Publisher: Printer: ISBN: University of Groningen Groningen, The Netherlands Ipskamp Drukkers B.V. Enschede, the Netherlands 978-90-367-6407-0
Modeling of Decision Making Processes in Supply Chain Planning Software. a theoretical and empirical assessment of i2 TradeMatrix
Modeling of Decision Making Processes in Supply Chain Planning Software a theoretical and empirical assessment of i2 TradeMatrix Modeling of Decision Making Processes in Supply Chain Planning Software
From Immunotherapy of Cancer to the Discovery of Kidney Cancer Genes
ISSN 2154-4006 The Genetic Basis of Human Disease zbar Colloquium series on Series Editor: Michael Dean, Ph.D., Head, Human Genetics Section, Senior Investigator, Laboratory of Experimental Immunology
Water Use of Forests in the Netherlands
Water Use of Forests in the Netherlands MISSION: Alterra is the main centre of expertise on rural areas and water management in the Netherlands. It was founded 1 January 2000. Alterra combines a huge range
A* Planning in Discrete Configuration Spaces of Autonomous Systems
A* Planning in Discrete Configuration Spaces of Autonomous Systems ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam, op gezag van de Rector Magnificus prof.
Workflow Support for the Healthcare Domain
Workflow Support for the Healthcare Domain register patient check patient data physical examination make documents consultation give information Ronny Mans Workflow Support for the Healthcare Domain CIP-DATA
Guide for Data Visualization and Analysis using ACSN
Guide for Data Visualization and Analysis using ACSN ACSN contains the NaviCell tool box, the intuitive and user- friendly environment for data visualization and analysis. The tool is accessible from the
M110.726 The Nucleus M110.727 The Cytoskeleton M340.703 Cell Structure and Dynamics
of Biochemistry and Molecular Biology 1. Master the knowledge base of current biochemistry, molecular biology, and cellular physiology Describe current knowledge in metabolic transformations conducted
Interaction Protocols in PARADIGM PROEFSCHRIFT
Interaction Protocols in PARADIGM Extensions to a Modeling Language through Tool Development PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus
Exploring the practical benefits of argumentation in multi-agent deliberation
Exploring the practical benefits of argumentation in multi-agent deliberation This research was supported by the Netherlands Organisation for Scientific Research (NWO) under project number 612.066.823.
FOR THE TIME BEING: Accounting for inconclusive findings concerning the effects of temporary employment relationships on solidary behavior of
FOR THE TIME BEING: Accounting for inconclusive findings concerning the effects of temporary employment relationships on solidary behavior of employees This research is funded by the Netherlands Organization
Patterns of order processing
Patterns of order processing A study of the formalization of the ordering process in order-driven manufacturing companies Gera A. Welker Uitgever: Labyrint Publications Pottenbakkerstraat 15 17 2984 AX
Measuring and improving the quality of care from the healthcare user perspective: the Consumer Quality Index. Marloes Zuidgeest
Measuring and improving the quality of care from the healthcare user perspective: the Consumer Quality Index Marloes Zuidgeest ISBN 978 94 6122 107 0 2011 M. Zuidgeest, Bergschenhoek, the Netherlands Cover
Transport Infrastructure Slot Allocation. Kaspar Koolstra
Transport Infrastructure Slot Allocation Kaspar Koolstra Transport Infrastructure Slot Allocation Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van
CONCEPTUAL PROGRESS IN ECONOMICS. Abstraction of social kinds versus idealization
CONCEPTUAL PROGRESS IN ECONOMICS Abstraction of social kinds versus idealization Doctoral Dissertation for Philosophy Conceptual Progress in Economics Menno Rol University of Groningen Faculty of Philosophy
Event-driven control in theory and practice
Event-driven control in theory and practice Trade-offs in software and control performance PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Technische Universiteit Eindhoven, op gezag van de
TOP. to the. Rescue. Bas Lijnse. Task-Oriented Programming For Incident Response Applications
Task-Oriented Programming For Incident Response Applications TOP to the Rescue Bas Lijnse TOP to the Rescue Task-Oriented Programming for Incident Response Applications Bas Lijnse This research has been
Leisuring Landscapes
Leisuring Landscapes On emergence, transitions and adaptation PhD Thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance
A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man. Niek C.A.
A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man Niek C.A. van de Pas A physiologically based kinetic model for the prediction of plasma cholesterol
Performance Optimization of Multi-Tenant Software Systems
Performance Optimization of Multi-Tenant Software Systems Performance Optimization of Multi-Tenant Software Systems PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Technische Universiteit
Control of Gene Expression
Control of Gene Expression What is Gene Expression? Gene expression is the process by which informa9on from a gene is used in the synthesis of a func9onal gene product. What is Gene Expression? Figure
Websites for children: Search strategies and interface design Three studies on children s search performance and evaluation. Hanna Jochmann-Mannak
Hanna Jochmann-Mannak Websites for children: Search strategies and interface design Three studies on children s search performance and evaluation Websites for children: Search strategies and interface
How To Design A System For A Task
TASK-BASED USER INTERFACE DESIGN Martijn van Welie SIKS Dissertation Series No. 2001-6. The research reported in this thesis has been carried out under the auspices of SIKS, the Dutch Graduate School for
Targeted therapy in oncology: mechanisms and toxicity
Targeted therapy in oncology: mechanisms and toxicity Neeltje Steeghs Targeted therapy in oncology: mechanisms and toxicity ISBN/EAN: 978-90-9024614-7 Lay-out: Grafisch bureau Christine van der Ven, Voorschoten
Cognitive Models for Training Simulations. Annerieke Heuvelink
Cognitive Models for Training Simulations Annerieke Heuvelink SIKS Dissertation Series No. 2009-24. The research reported in this thesis has been carried out under the auspices of SIKS, the Dutch Graduate
Quality of life in dementia From concept to practice
Quality of life in dementia From concept to practice Carla Schölzel-Dorenbos Colophon Quality of life in dementia From concept to practice C.J.M. Schölzel-Dorenbos, 2011 All rights reserved. No part of
Crossing Cultural Chasms
Crossing Cultural Chasms towards a culture-conscious approach to design Annemiek van Boeijen Crossing Cultural Chasms towards a culture-conscious approach to design Proefschrift ter verkrijging van de
Aspects of Feedback in Intelligent Tutoring Systems for Modeling Education
Aspects of Feedback in Intelligent Tutoring Systems for Modeling Education Proefschrift ter verkrijging van de graad van doctor aan de Open Universiteit op gezag van de rector magnicus prof. mr. A. Oskamp