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1 да' дгдадедцд д дедфдд дфдаде дбд дгдадедфд»дфд»дбдедфдд дфдфдедгдедфдд д дадгдцд дед д дддгдед»д дадедддгдидг дцдедцд дед дгд ддд : дфдадедддбддд ддд да. дадгд д дадфдфддд д дгдддгда дбд дгдадедфд»дфд»дбдедфддд д»дбдфд»дфд»дбдедад 1st DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, UNIVERSITY OF ATHENS, GREECE Head: Professor A.Antsaklis GYNAECOLOGICAL ONCOLOGY UNIT o 3 д д д д д длд д дбднд д д д д д д д д д д»д д д д д д д 3rd Workshop on Gynaecological Oncology Endorsed by дцдедад ддд ддд дд дбд»дгдедгд»д ддд дад д дц дбд дгдадедфдцд дгдц дбд дгдадедфд»дфд»дбдедфд» дфдад дфдедгд» FERTILITY PRESERVATION FOR WOMEN WITH GYNAECOLOGICAL CANCER дхдцдбд д»д дад дед»д 2011 дгдцдбдад д» дцдедцдедгдцд д д дгдцдцд дедадфд» дфдцдгд д д» дадедддгдидг FEBRUARY 25-27, 2011 MEGARON ATHENS INTERNATIONAL CONFERENCE CENTRE, GREECE д д д д д д длд длд д д д Final Program

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3 fiав & А appleapple Chairman of Seminar & Organizing Committee Ая / Aris Antsaklis applefi apple / Scientific Coordinator АяАУАв Ав / Alexandros Rodolakis А appleapple / Organizing Committee Ас д / George Vlachos fi / Nikolaos Thomakos АяАУАв Ав / Alexandros Rodolakis Авfiapple / Dimitrios Haidopoulos apple appleapple/ Scientific Committee fiав Аяfi / Theodoros Agorastos David Cibula Nikoletta Colombo Dominik Denschlag АУ / Stelios Fotiou Vesna Kesic АВАв / Dimitrios Loutradis Ая / Antonios Makriyiannakis Philippe Morice Ав / Evagelos Paraskevaidis Nick Reed ESGO FERTILITY PRESERVATION TASK FORCE Dominik Denschlag (Germany) Vesna Kesic (Serbia) Philippe Morice (France) Nick Reed (UK) Alexandros Rodolakis (Greece) Achim Schneider (Germany) ESGO INVITED SPEAKERS David Cibula (Czech Republic) Nicoletta Colombo (Italy) Dominik Denschlag (Germany) Daniela Fischerova (Czech Republic) Vesna Kesic (Serbia) Philippe Morice (France) Fedro Peccatori (Italy) Nick Reed (UK)

4 Prologue Dear colleagues Gynaecological malignancies are most often diagnosed among postmenopausal women. During the last decades there has been an increasing incidence of these malignancies to be arising in premenopausal women. On the other hand, the delaying childbearing that is most often observed recently, has led to a significant increase in the number of women diagnosed with a gynaecological malignancy and have not completed their reproductive potential. Fertility preservation for these women without compromising the final oncological outcome is a provocative and most challenging issue. The Gynaecological Oncology Unit of the 1st Department of Obstetrics and Gynaecology of the University of Athens is traditionally organizing every year seminars devoted to different topics of Gynaecological Oncology. On February 25-27, 2011 our Unit will organize a Workshop on А Fertility Preservation for Gynaecological Cancer patientsа. The program will be focused on the following topics: - PatientsА» selection and eligibility criteria to enter to a Fertility Preservation Protocol. - Description of all new innovative surgical and medical interventions for the management of the most common gynaecological cancers. - Assisted reproductive technologies that could be applied in these patients. Issues like embryo cryopreservation, oocyte banking, ovarian preservation and transposition, cryopreservation of ovarian tissue and orthotopic autologous ovarian transplantation will be analysed. - The appropriate time, way and facility used for delivery will also be discussed. - The availability and the necessity of developing Fertility Preservation Centres as well as the need for registering all conservatively treated patients to a centralized web based database will also be emphasized. - The goals and activities of the Fertility Preservation Task Force will be outlined. The Workshop will be endorsed by the European Society of Gynaecological Oncology (ESGO). We would like to welcome all of you to attend and actively participate in our Workshop. With best regards The Scientific Coordinator Alexandros Rodolakis Ass. Professor of Gynaecological Oncology Athens University, Greece The President of the Workshop Aris Antsaklis Professor of Obstetrics and Gynaecology Athens University, Greece

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6 дцдлд дмдмдкд д д д д д длд длд д д д 25 / Friday, February 25th 08:00-08:45 АУ / Registrations 08:45-09:00 / President's Welcome Ая A. / Antsaklis A. / Introduction Ав A. / Rodolakis A. 09:00-09:30 / Lecture Ав: Ая Ая. / Chair: Antsaklis A. appleав : Ам, Ав / Epidemiological features and age adjusted incidence of the most common gynecologic malignancies: Cervical, ovarian and endometrial cancer Kesic V. 09:30-10:30 длая 1 / PLENARY SESSION 1 Ам / Cervical carcinoma Ав: Ам Ас. - appleapple. / Chair: Creatsas G. - Papaspyrou E. 09:30-10:00 Screening : fi, applefi АУ / Cervical cancer screening: past, present and future Аяfi. / Agorastos Th. 10:00-10:30 Аяapple : АК АУ appleау / Traditional management of cervical carcinoma: The evolution of surgical approach. / Fotiou S. 10:30-11:00 - АмАУ / Coffee break 11:00-13:00 длая 2 / PLENARY SESSION 2 apple Ав fi / Fertility sparing procedures for cervical carcinoma patients Ав: Ав A. - appleappleapple Ая. / Chair: Rodolakis A. - Protopappas A. 11:00-11:30 АмАв / Cervical conization Амfiapple Ас. / Koliopoulos G. 11:30-12:00 Ам / Radical Abdominal Trachelectomy (RAT) Cibula D. 12:00-12:30 Амapple / Radical Vaginal Trachelectomy (RVT) Morice Phil. 12:30-13:00 apple apple / Neoadjuvant Chemotherapy (NACT) and trachelectomy Cibula D.

7 Scientific Program 25 / Friday, February 25th 13:00-13:30 / Lecture Ав: Ам. / Chair: Kassanos D. Авapple apple / Preoperative staging and perioperative management of cervical carcinoma patients Fischerova D. 13:30-15:00 apple / Break 15:00-16:00 длая 3 / PLENARY SESSION 3 Аяapple applefi apple / Reproductive outcome of conservatively treated cervical cancer patients Ав:. -. / Chair: Diakomanolis E. - Panoskaltsis Th. 15:00-15:30 applefi Ав / After cervical conization Kesic V. 15:30-16:00 applefi / After Radical Vaginal and Abdominal Trachelectomy Morice Phil. 16:00-16:30 - АмАУ / Coffee break 16:30-18:00 длая 4 / PLENARY SESSION 4 apple apple / Obstetrical management of conservatively treated cervical carcinoma patients Ав: A A. - Ас. / Chair: Antsaklis A. - Dekavalas G. 16:30-17:00 apple Авfi fiapple : fi fi - Ам / Appropriate obstetrical monitoring and delivery :Vaginal vs cesarean approach. / Mesogitis S. 17:00-17:30 fi fi / The case of preterm delivery Ас. / Daskalakis G. 17:30-18:00 Ам : apple / Cervical carcinoma during pregnancy: Diagnosis and management Peccatori F. 18:00-19:00 длая 5 / PLENARY SESSION 5 Ам АУ / Breast cancer in the young patient Ав: Kfiapple A. - appleав. / Chair: Keramopoulos A.- Papadimitriou Ch. 18:00-18:30 Аяapple apple / Management of reproductive age breast cancer patient Ам. / Dimitrakakis K. 18:30-19:00 Ам / Breast cancer and pregnancy Peccatori F.

8 дцдлд дмдмдкд д д д д д длд длд д д д 26 / Saturday, February 26th 09:00-09:30 / Lecture Ав: д. / Chair: Dousias V. apple / Primary management of ovarian cancer patients д Ас. / Vlachos G. 09:30-11:00 длая 6 / PLENARY SESSION 6 fi : apple fi appleау / Fertility sparing options for Individual ovarian tumors: Patients' selection and oncological outcome Ав: Ав A. - apple Ая. / Chair: Rodolakis A. - Bamias A. 09:30-10:00 applefi / Epithelial ovarian tumors Colombo N. 10:00-10:30 А (BOTs) / Borderline Ovarian Tumors (BOTs) Morice Phil. 10:30-11:00 apple fi / Non-epithelial ovarian tumors Colombo N. 11:00-11:30 - АмАУ / Coffee break 11:30-13:00 длая 7 / PLENARY SESSION 7 apple / Conservative management of ovarian carcinoma Ав: fiapple A.. - д Ас. / Chair: Dimopoulos A.M. -Vlachos G. 11:30-12:00 apple - Авapple / Surgical staging for conservatively treated ovarian cancer patients Авfiapple. / Haidopoulos D. 12:00-12:30 appleау Авapple apple applefi Ав fi / Requirements for staging and follow-up of ovarian malignant mass in patients with intention to preserve fertility Fischerova D. 12:30-13:00 apple apple applefi / Chemotherapy for conservatively treated ovarian cancer patients Reed N. 13:00-13:30 / Lecture Ав: fiapple Ас. / Chair: Sakellaropoulos G. appleав HPV- fi / Impact of HPV vaccination on cervical cancer incidence Ав. / Paraskevaides E. 13:30-15:00 apple / Break

9 Scientific Program 26 / Saturday, February 26th 15:00-16:00 длая 8 / PLENARY SESSION 8 Аяapple / Reproduction and ovarian carcinoma Ав: M I. - apple N. / Chair: Messinis I. - Papantoniou N. 15:00-15:30 Аяapple appleау apple / Reproductive and obstetrical outcome of conservatively treated ovarian cancer patients M A. / Makriyiannakis A. 15:30-16:00 apple Авfi fiapple : fi fi - Ам / Appropriate obstetrical monitoring and delivery: Vaginal vs cesarean approach д. / Vlahos N. 16:00-17:00 длая 9 / PLENARY SESSION 9 Ам Ав / Endometrial carcinoma Ав:. - д Ас. / Chair: Fotiou S.- Vorgias G. 16:00-16:30 Аяapple fi Ав / Traditional approach of early-stage endometrial carcinoma applefi A. / Daponte A. 16:30-17:00 АК АУ apple Ав / The hormonal profile and the rationale for a conservative management of selected endometrial cancer patients Reed N. 17:00-17:30 - АмАУ / Coffee break 17:30-18:30 длая 10 / PLENARY SESSION 10 fi Ав / Fertility sparing approach to endometrial carcinoma Ав: apple дл. - Ас. / Chair: Papageorgiou I. -Magiakos G. 17:30-18:00 fi - apple / Histological and clinical evaluation of the disease - patients' selection Ав A. / Rodolakis A. 18:00-18:30 apple appleау, apple АвАвАУ apple Ав apple / Treatment options, follow- up and the reproductive outcome of conservatively treated endometrial cancer patients. / Thomakos N.

10 дцдлд дмдмдкд д д д д д длд длд д д д Ам 27 / Sunday, February 27th 09:00-09:30 / Lecture Ав: A. / Chair: Makriyiannakis A. apple apple fi : apple appleававау АУ; / Assisted reproduction and gynecologic malignancies. Is there any evidence based correlation? Denschlag D. 09:30-11:00 длая 11 / PLENARY SESSION 11 АУАв apple apple fi / Assisted reproductive techniques for conservatively treated gynaecological cancer patients Ав: АВАв. -. / Chair: Loutradis D. -Makris N. 09:30-10:00 / Ovarian preservation and transposition Ав K. / Stefanidis K. 10:00-10:30 дцapple Ав / Oocyte banking and embryo cryopreservation. / Drakakis P. 10:30-11:00 Ам fi fi / Ovarian tissue cryopreservation and orthotopic autologous ovarian transplantation Ак дл. -. / Zervomanolakis I. - Pitsos M. 11:00-11:30 - АмАУ / Coffee break 11:30-12:30 длая 12 / PLENARY SESSION 12 apple (IVF) fi / In Vitro Fertilization( IVF) for conservatively treated gynaecological cancer patients Ав: дц д. -. / Chair: Tarlatzis V. -Mastrominas M. 11:30-12:00 apple Авfi apple / Evaluation of reproductive potential and age limitations Ая Ас. / Antonakis G. 12:00-12:30 длавfi applefi applefi appleapple / The Ideal protocol and limitation of attempts fiapple K. / Dafopoulos K.

11 Scientific Program Ам 27 / Sunday, February 27th 12:30-13:00 / Lecture Ав: Ая. / Chair : Akrivos Thr. appleау apple: Аяfi, Авfi fi Ав appleау / Completion surgery: The necessity, the ideal timing and the appropriate procedure TАУ A. / Tserkezoglou A. 13:00-14:00 длая 13 / PLENARY SESSION 13 А Ав Ав Ав fi fi / ESGO fertility preservation task force Ав / Chair: Colombo N. 13:00-13:20 ESGO: АК apple fi / ESGO: The mission and the vision Colombo N. 13:20-13:40 А applefi apple, Авfi АУАв А Ав Ав fi fi / The role, the activities and the future plans of the ESGO Fertility Preservation Task Force Denschlag D. 13:40-14:00 Аяfi appleapple apple АУ Ав fi / The need for centralization of the multidisciplinary management of all conservatively treated gynecological cancer patients Ав A. / Rodolakis A. 14:00 АВ - apple / Workshop ending - Closing remarks Ав A. / Rodolakis A.

12 АсАУ / General Information Амfi / Registration Fee Авfi / Trainees: 80е АвАУ / Specialists: 150е АК АУ А» fi Ав. Registrations for the congress will be able to be proceeded throughout the seminar timetable. Ас / Course Language apple Ас Ая. apple fi. The official languages are Greek and English. Simultaneous translation will be provided for the participants АК / Meeting Dates 25, 26 & Ам Friday 25th, Saturday 26th & Sunday 27th of February 2011 дцfiapple / Venue АУ АУ Авfi АмАУ Ая Megaron Athens International Conference Centre Авfi / Credits дц Ав applefi & Ас (..Ас..) 5 fi fi дл appleав The Hellenic Society of Obstetrics & Gynaecology has allocated with 5 credit points (CME) for attending the seminar. длав / Meeting Website Ас / Secretariat Ая. 118, Ая , дц.: , md@mdcongress.gr 118 Al. Panagouli Str., Agia Paraskevi, , Athens, GreeceTel: , md@mdcongress.gr

13 fiав - А АУ / President - Speakers Cibula David Colombo Nicoletta Denschlag Dominik Fischerova Daniela Kesic Vesna Morice Philippe Peccatori Alessandro Fedro Reed Nick Аяfi fiав Agorastos Theodoros Ая Akrivos Thrasivoulos Ая Antsaklis Aris Ая Ас Antonakis Georgios д Ас Vlachos Georgios д fi Vlahos Nikolaos д Ас Vorgias Georgios applefi АяАУАв Daponte Alexandros Ас Daskalakis Georgios Ас Dekavalas Georgios Ам Dimitrakakis Konstantinos fiapple Ая - АУ Dimopoulos Athanasios - Meletios Diakomanolis Emmanuel АУ Drakakis Petros Ак дл Zervomanolakis Ioannis fi Thomakos Nikolaos Ам Kassanos Dimitrios Амfiapple Ая Keramopoulous Antonios Амfiapple Ас Koliopoulos Georgios Ам Ас Creatsas Georgios Professor of Obstetrics and Gynaecology, Charles University, 1st Faculty of Medicine, Czech Republic, Prague Professor of Obstetrics and Gynaecology University of Milano, Italy Professor of Obstetrics and Gynaecology, Germany, MD PhD, FRCSC Obstetrician Gynaecologist, Department of OB/GYN, Charles University, 1st Faculty of Medicine, Czech Republic, Prague Professor of Obstetrics and Gynaecology, Department of OB/GYN, Clinical Center of Serbia MD, Department of Gynaecological Clinic of Institute Gustave - Roussy, France MD PhD, Director and Consultant Fertility and Pregnancy in Oncology Project, Department of Medicine Division of Clinical Haemato-Oncology MD, Beatson Oncology Centre Gartnavel General Hospital, Scotland, UK Ам & Ас, / /Ас Ам Ая... Professor of Obstetrics & Gynaecology, Head of 4th Department of Obstetrics & Gynaecology, Aristotle University of Thessaloniki. / Ас Ам.Ая... "" Former Head of Department of Gynaecological, "Metaxa" Hospital Ам & Ас, / Ая/Ас Ам / Ая Professor of Obstetrics & Gynaecology, Head of 1st Department of Obstetrics & Gynaecology, University of Athens apple. Ам & Ас / Assistant Professor of Obstetrics & Gynaecology, University of Patras Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology, University of Athens Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology, University of Athens apple Ая,.Ая... "" 1st Consultant, "Metaxa" Hospital apple. Ам & Ас / Assistant Professor of Obstetrics & Gynaecology, University of Thessaly apple. Ам & Ас / Ая Assistant Professor of Obstetrics & Gynaecology, University of Athens Ам & Ас, / /Ас Ам / Professor of Obstetrics & Gynaecology, Head of Department of Obstetrics & Gynaecology, University of Patras АВАУ & Ас / Ая Lecturer of Obstetrics & Gynaecology, University of Athens Ам - А / Ая Professor of Patholgy - Oncology, University of Athens Ам & Ас / Ая Professor of Obstetrics & Gynaecology, University of Athens apple. Ам & Ас / Ая Assistant Professor of Obstetrics & Gynaecology, University of Athens - Асfi, Ая Obstetricians - Gynaecologist, Athens apple, Ая /Ас Ам / Ая Consultant, 1st Department of Obstetrics & Gynaecology, University of Athens Ая. Ам & Ас, / Ас /Ас Ам / Ая Associate Professor of Obstetrics & Gynaecology, Head of 3rd Department of Obstetrics & Gynaecology, University of Athens apple. Ам & Ас / Ая, / АмАУ "длая" Assistant Professor of Obstetrics & Gynaecology, University of Athens, Head of Breast Centre of "IASO" Hospital АВАУ & Ас / дл Lecturer of Obstetrics & Gynaecology, University of Ioannina Ам & Ас, / д /Ас Ам / Ая Professor of Obstetrics & Gynaecology, Head of 2nd Department of Obstetrics & Gynaecology, University of Athens

14 АВАв Loutradis Dimitrios Ас Magiakos Georgios fi Makris Nikolaos Ая Makriyiannakis Antonios Mastominas Minas appleав Mesogitis Spyridon дл Messinis Ioannis apple АяАУ Bamias Aristotelis fiapple Ам Dafopoulos Konstantinos o д Dousias Vasilios fiав Panoskaltsis Theodoros apple дл Papageorgiou Ioannis appleав Papadimitriou Christos apple fi Papantoniou Nikolaos appleapple Papaspyrou Eirini Ав Paraskevaidis Evagelos Ав Pitsos Miltiadis appleappleapple Ая Protopappas Athanasios Ав АяАУАв Rodolakis Alexandros fiapple Ас Sakellaropoulos Gerasimos Ав Ам Stefanidis Konstantinos дц д Tarlatzis Vasilios дцау Ая Tserkezoglou Aliki АУ Fotiou Stelios Авfiapple Haidopoulos Dimitrios Ам & Ас / Ая Professor of Obstetrics & Gynaecology University of Athens / Ая Ас дц Ая.А..Ая " " Head of 1st Department of Gynaecology, "Agios Savvas" Hospital Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology University of Athens Ам & Ас / Ам Professor of Obstetrics & Gynaecology University of Crete - Асfi, / АмАУ "АУ" Ая Obstetrician - Gynaecologist, Head of "Embryogenesis" Athens Centre Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology University of Athens Ам & Ас, / /Ас Ам / Professor of Obstetrics & Gynaecology, Head of Department of Obstetrics & Gynaecology, University of Thessaly apple. Ам - А / Ая Assistant Professor of Pathology - Oncology University of Athens АВАУ & Ас / Lecturer of Obstetrics & Gynaecology, University of Thessaly Ая. Ам & Ас / дл Associate Professor of Obstetrics & Gynaecology University of Ioannina - Асfi, MD, PhD, MRCOG, CCST (UK), Ая Obstetricians - Gynaecologist, MD, PhD, MRCOG, CCST (UK), Athens Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology University of Athens A. Ам - А / Ая Associate Professor of Pathology - Oncology University of Athens Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology University of Athens / дц.ас..ая. "АяАв" Head of Department of Pathological Anatomy, "Alexandra" Hospital Ам & Ас, / /Ас Ам / дл Professor of Obstetrics & Gynaecology, Head of Department of Obstetrics & Gynaecology, University of Ioannina - Асfi, Ая Obstetricians - Gynaecologist, Athens АВАУ & Ас / Ая Lecturer of Obstetrics & Gynaecology, University of Athens Ая. Ам Ас А / Ая Associate Professor of Gynaecological Oncology University of Athens apple. Ам & Ас / Ая Assistant Professor of Obstetrics & Gynaecology University of Athens apple. Ам & Ас / Ая Assistant Professor of Obstetrics & Gynaecology University of Athens Ам & Ас, / Ая' /Ас Ам Ая... Professor of Obstetrics & Gynaecology, Head of 1st Department of Obstetrics & Gynaecology, Aristotle University of Thessaloniki / д Ас Ам, Ая.А..Ая "АяАсдлА Аяд д Ая" Head of 2nd Department of Gynaecology, "Agios Savvas" Hospital Ая. Ам & Ас / Ая Associate Professor of Obstetrics & Gynaecology, University of Athens АВАУ & Ас / Ая Lecturer of Obstetrics & Gynaecology, University of Athens

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