Walter J. Crinnion ND

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1 A Mere Telling of the Timeline Tale of Your Life and Trauma as Told by your Telomeres and Telomerase (along with a foretelling of your vitality and Time left) Walter J. Crinnion ND

2 Just how many cell divisions do you have left?

3 Just how many cell divisions do you have left? For those with limited reproduction ability you have stem cells

4 Stem Cells Tissue and cell specific A bank of healthy stem cells insures Cellular replacement Tissue and organ function The balance between cell death and cell replacement is strictly maintained Reduced cell replacement is the cause of aging and chronic disease

5 Declining Cell Replication oxidative stress Shorter Telomeres Diminished Telomerase activity replicative senescence

6 Cell Reproduction Telomeres at the end of each chromosome allow the chromosomes to perfectly reproduce. Telomeres get shorter with each reproduction and via aging, oxidative stress and emotional stress If telomeres get too short chromosomes get stuck in reproduction

7

8

9 Telomerase Replaces lost telomere length Activity of telomerase is reduced by oxidation and stress Telomerase activity inverse to level of body inflammation

10 Cells with high telomerase activity All stem cells Rapidly dividing cells: Epithelium (all surface linings) Hair follicles Liver RBC and WBC Liver, Reproductive Organs, Spleen Brain

11 Telomere Length Lost in each cell reproduction 20 base pairs 200 base pairs High Antioxidant Levels Low Antioxidant Levels

12 What else inactivates telomerase Age (remember previous slide)- PMID Lack of sleep PMID Vehicular exhaust PMID Cadmium and other toxicants (all are proinflammatory and pro-oxidant)-pmid Sugar-sweetened soda pop- PMID Sedentary Life style - Lack of physical fitness High Homocysteine

13 King Soloman - Proverbs A merry heart does good like a medicine Or A cheerful heart works an excellent cure

14 King Soloman - Proverbs A merry heart does good like a medicine Or A cheerful heart works an excellent cure But, a broken (stabbed) spirit dries the bones

15 Emotions, trauma (PTSD) and stress Pessimism Depression Major life stresses Perceived stress Chronic caregiving Childhood trauma Domestic abuse Prenatal stress (mom going through abuse / trauma) Pubmed PMID , , , , , , , ,

16 I have never met an incurable disease, but, I have met incurable people WJC

17 The Key The Perception Of Stress NOT The stressful situation

18 Health Problems with short telomeres and telomerase inactivity Obesity Cardiovascular disease Respiratory diseases including lung cancer Diabetes and impaired glucose tolerance Reduced kidney function Depression Vascular dementia Increased mortality Cancer incidence and mortality PubMed PMID: , , , , , , , , , ,

19 Can telomerase activity be restored?

20 Diet Choices for Shorter Telomeres Processed meats (PMID: ) Dairy Butter and other saturated fats (PMID: ) High calorie diet (PMID: ) High sugar (PMID: , ) Duh! High BMI

21 PMID:

22 PMID:

23 Dietary Choices for Longer Telomeres High vegetable intake

24

25 Findings in 56 Tuscans (30-70 yrs) Diets high in vegetables associated with longer TL Tomatoes Peppers Carrots Root vegetables Antioxidant vitamins High fruits

26 Dietary Choices for Longer Telomeres High vegetable intake (PMID: ) High fruit intake (PMID: )

27 PMID:

28 PMID:

29 Dietary Choices for Longer Telomeres High vegetable intake (PMID: ) High fruit intake (PMID: ) High in omega 3 oils

30 Dietary Choices for Longer Telomeres High vegetable intake (PMID: ) High fruit intake (PMID: ) High in omega 3 oils Diets high in antioxidants and minerals Caloric restriction - (PMID: ) Probably the reason for improved telomere length in several weight loss studies

31 PMID:

32 Nurses Health Study Ongoing study of 121,700 nurses Began in 1976 A subset of 38,825 provided blood samples in 1989/ with telomere length and food-frequency questionnaire completed were selected Telomere length measured in WBC

33 Mediterranean Diet High Intake of: Vegetables Fruits Nuts Legumes Whole grains Olive oil Moderately high intake of: Fish Red wine Low intake of: Dairy Meat Poultry

34 Documented health benefits to amount of adherence to Med. Diet Reduction in overall mortality Reduction of Cardiovascular illness Reduction of all chronic diseases Increased lifespan

35 Dietary assessment in this study Participants filled out food frequency questionnaire in 1980 for previous year s diet Re-filled out every 4 years With expanded 130-food list Alternated Mediterranean Diet Score Rates 0-9 for adherence to the MD

36 Results Mean age: 59 yrs Age range Telomere length inversely correlated with age Smokers had shorter telomeres The higher the compliance with Mediterranean diet the longer the telomeres were ( higher age adjusted telomere length ) Statistically significant No association with individual diet components

37 PMID:

38 This study 217 elderly Italians from Campania Mean age 78 Telomere length & telomerase activity tested All assessed with: Full medical history Lab, history and physical Functional and cognitive status Assessment for chronic illness Dietary assessment Activities of Daily Living

39 Health rating Healthy : top 10% in ADL scale (score >90) Absence of HTN, CHF, MI, Peripheral vasc. Disease, stroke, dementia, COPD Unhealthy : ADL score <80 Two or more of the above diseases

40 Dietary Assessment Same Mediterranean Diet Score method Rating 0-9 Low adherence: <3 ( 32.3%) Medium adherence: 4-5 ( 31.3%) High adherence: >6 (36.4%)

41 Results The 36% with high adherence had significantly longer telomeres and significantly greater telomerase activity. And Lower CRP, IL-6, TNF-alpha Inflammation independently associated with telomerase activity (inversely)

42 Vitamin D3 Nutrients

43 PMID:

44 PMID:

45 Nutrients Vitamin D3 Folic acid

46 PMID:

47 Nutrients Vitamin D3 Folic acid is this the homocysteine connection? Antioxidant supplements

48 PMID:

49 Nutrients Vitamin D3 Folic acid is this the homocysteine connection? Antioxidant supplements Vit E and the tocotrienols High food antioxidant levels

50 PMID:

51 Nutrients Vitamin D3 Folic acid is this the homocysteine connection? Antioxidant supplements Vit E and the tocotrienols High food antioxidant levels NAC (in vitro)

52 Nutrients Vitamin D3 Folic acid is this the homocysteine connection? Antioxidant supplements Vit E and the tocotrienols High food antioxidant levels NAC (in vitro) L-carnosine (in vitro)

53 Botanicals antioxidants??? Green tea differing in-vitro results But.

54 PMID:

55 Chinese Tea Green unfermented Oolong partially fermented Black - fermented

56 Chinese Tea Green unfermented Oolong partially fermented Black - fermented

57 Chan, et al 2006 Chinese men and women over age 65 In men, intake of Chinese tea was significantly associated with longer telomere length Those who drank >3 cups daily (>750 ml per day) had greater telomere length representing approximately 5 years of life

58 Botanicals antioxidants??? Green tea differing in-vitro results BUT, clear in-vivo results Astragalus

59 PMID:

60 PMID:

61 Botanicals antioxidants??? Green tea differing in-vitro results BUT, clear in-vivo results Astragalus specific extract???? Rhodiola unpublished research Brassica unpublished research

62 If a wounded spirit can dry the bones (and make for shorter telomeres)

63 If a wounded spirit can dry the bones (and make for shorter telomeres) Can a merry heart work and excellent cure?

64 Meditation, Yoga and Qi Gong

65 PMID:

66 PMID:

67 PMID:

68 PMID:

69 PMID:

70 Let s put this all diet stuff together Low saturated fats Low Omega 6 Low sugar No preserved meats High fruits and vegies Brassica Fish intake High antioxidant content

71 Mediterranean Diet High Intake of: Vegetables Fruits Nuts Legumes Whole grains Olive oil Moderately high intake of: Fish Red wine Low intake of: Dairy Meat Poultry

72 A healthy telomere lifestyle Mindfulness meditation Yoga, Tai chi, Qi gong Exercise Good sleep Clean air and clean food Great outlook on life

73 Booth 331 Book Signing & Information on Environmental Medicine Educational Offerings

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