Multi-modal image registration of CT and Optical Coherence Tomography (OCT) images

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1 Multi-modal image registration of CT and Optical Coherence Tomography (OCT) images (Dipl.-Math.) Jesús Díaz Díaz Research Assistant Insitute of Mechatronic Systems (imes) - University of Hannover www: jesus.diazdiaz@imes.uni-hannnover.de

2 Overview Introduction to OCT and comparison to other imaging technologies Research project at the IMES (Leibniz University of Hannover) Multi-modal image registration (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 2

3 Optical Coherence Tomography (OCT) Features of OCT Interferometric measurement principle Non invasive, non contact 3D imaging Resolution: 2-15 µm Imaging depth depends on light penetration depth in tissue (~ 1 mm 3 mm) Light source Fiber coupler Axial/depth scan PD Transverse scan Data processing Specimen Thorlabs Inc. (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 3

4 Overview of imaging procedures Overview of imaging technologies Imaging Technolo gy Typical resolutio n (µm) Imaging Depth (mm) Syste m Cost Speed Features Microsco py Low Video rate Non-Invasive OCT Low Video rate Non-Invasive Ultrasoun d Low Video rate Contact MRI High 50ms Non-Invasive CT High 50ms Non-Invasive, Radiation Approach: Combination of two different imaging technologies (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 4

5 Research project at the imes Cochlea Implant (CI) Insertion of an electrode array into the cochlea for electrical stimulation of the auditory nerve State-of-the art: Exposition of functional important structures ensuring their safety by resecting big parts of the lateral skull. Opening of the cochlea by drilling a hole with a diameter of mm (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 5

6 Research project at the imes Minimal Invasive Cochlea Implant High-accurate preoperative positioning of the drilling device for a direct access to the cochlea Our approach for navigation Surgical navigation based on landmarks, different imaging technologies and robotics Two scale approach using CT and OCT images Registration of CT and OCT images (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 6

Comparison of CT and OCT images Images from a temporal bone specimen mastoid cells 10mm mastoid cells 1mm Flat panel volumetric computerized tomography (used for surgical planning) Resolution: 0.

7 Comparison of CT and OCT images Images from a temporal bone specimen mastoid cells 10mm mastoid cells 1mm Flat panel volumetric computerized tomography (used for surgical planning) Resolution: 0.148mm (isotropic) Optical coherence tomography (used for intraoperative guidance) Resolution: 8.3 x 6.3 x 5 µm 3 (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 7

8 Registration of CT and OCT images Stereo optical localizer for an initial pose estimation of the OCT scan volume within the CT data Image registration of OCT and CT in order to calculate a corrective transformation T Apply T to the robot s endeffector guiding the surgical instrument (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 8

9 Results Before image registration Edges of the segmented OCT data (red) plotted into the correspondent VCT image; 4 exemplary slides (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 9

10 Results After image registration Edges of the segmented OCT data (red) plotted into the correspondent VCT image; 4 exemplary slides (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 10

11 Outlook Outlook Improvement of the registration methods due to modelbased approaches Robustness of registration due to changes in measurement and optimization methods Determination of the registration accuracy using highly accurate calibration objects This work is partially funded by the DFG (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 11

12 Gottfried Wilhelm Leibniz Universität Hannover Thank you for your attention! (Dipl.-Math.) J. Díaz Díaz / Multi-modal image registration of CT and OCT images / 2009 Slide 12

Image. 3.11.3 SW Review the anatomy of the EAC and how this plays a role in the spread of tumors.

Image. 3.11.3 SW Review the anatomy of the EAC and how this plays a role in the spread of tumors. Neoplasms of the Ear and Lateral Skull Base Image 3.11.1 SW What are the three most common neoplasms of the auricle? 3.11.2 SW What are the four most common neoplasms of the external auditory canal (EAC)