Vol. 20 No ,000 6,000 CD14
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1 Vol. 20No ,0006, , Onouchi DNA CD
2 Acute stage n106 Convalescent stage n68 Control subjects n22 SD White blood cells Mononuclear cells CD14monocytesmacrophages Lymphocytes CD4T cell CD8T cell CD19B cell All results for cell counts are expressed as10 9 l and meansem. Significant at p0.05 versus control subjects. Significant at p0.01 versus control subjects. 1 SIRS SIRSsystemic inflammatory response syndrome CD19B CD4T CD8T CD14 2 SIRS 610 systemic inflammatory response syndromesirs SIRS 1 SIRS EB
3 Vol. 20No l 2 p60 TNFRI 11 tumor necrosis facitor TNF interleukinil6 1 TNFTNFR TNF TNF 6 TNF TNF TNF receptortnfr TNF TNFR typetnfr 2 9 TNFR intravenous immunoglobulinivig TNF TNF 2 IL6 IL6 IL10 IL6 nuclear factor BNFB 10 3 NFB TNFIL1IL6 IL8monocyte chemoattractant protein 1 RNA NFB 3NFB IB DNA NFB binding sitenfb CD14 CD3T NFB CD14 NFB CD3T 45 IVIG CD14 NFB 6 12 NFB SIRS 7 NFB
4 IVIG TNF 1 IVIG IVIG in vitro T IVIG NFB activation receptor FcR 3 NFB MCP1monocyte chemoattractant protein1 RANTESregulated upon activation, normal T cell expressed and presumably secreted ICAM1intercellular adhesion molecule1 VCAM1vascular cell adhesion molecule1 inosinducible nitric oxide synthase COX2cyclooxygenase IVIG NFB T T NFB IVIG activation receptor FcR IVIG NFB FcR 1316 IVIG T T 17 2 IVIG TNF IVIG IgG IgG1 G1M2 IVIG GIM IVIG GIM2 GIM2 18 TNF TNF TNFreceptor type IVIG 19 TNF 4 T NFB CD3CD3T CD14CD14
5 Vol. 20No T NFB 6T NFB IVIG E 2 prostaglandin E 2 PGE 2 24 PGE 2 EP 14 PGE 2 EP 2 1
6 IVIG IVIG 7 NFB PG EP ,25dihydroxyvitamin D 3 1,25 OH 2 D 3 1,25OH 2 D 3 NFB E 26 NFB SIRS agents IVIG TNF Onouchi Y, et ala genomewide linkage analysis of Kawasaki diseaseevidence for linkage to chromosome 12. J Hum Genet , Onouchi Y, et alitpkc functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet , Furukawa S, et almononuclear cell subsets and coronary artery lesions in Kawasaki disease. Arch Dis Child , Furukawa S, et alperipheral blood monocyte macrophages and serum tumor necrosis factor in Kawasaki disease. Clin Immunol Immunopathol , Furukawa S, et alincreased levels of circulating intercellular adhesion molecule 1 in Kawasaki disease. Arthritis Rheum , Matsubara T, et altumor necrosis factoralpha inhibitory activity in urine of Kawasaki disease. Clin Immunol Immunopathol , Furukawa S, et alserum levels of p60 soluble tumor necrosis factor receptor during acute Kawasaki disease. J Pediatr , Hotta N, et alnfb activation in peripheral blood mononuclear cells in children with sepsis. Crit Care Med ,
7 Vol. 20No Ichiyama T, et alnfb activation in peripheral blood monocytesmacrophages and T cells during acute Kawasaki disease. Clin Immunol , Makata H, et alantiinflammatory effect of intravenous immunoglobulin in comparison with dexamethasone in vitroimplication for treatment of Kawasaki disease. Naunyn Schmiedebergs Arch Pharmacol , Ichiyama T, et alintravenous immunoglobulin inhibits NFB activation and affects Fcreceptor expression in monocytesmacrophages. Naunyn Schmiedebergs Arch Pharmacol , Ichiyama T, et alan immunoglobulin agent IVIGinhibits NFB activation in cultured endothelial cells of coronary arteries in vitro. Inflamm Res , Ichiyama T, et alintravenous immunoglobulin does not increase FcRB expression on monocytesmacrophages during acute Kawasaki disease. Rheumatology , Matsubara T, et alimmunological profile of peripheral blood lymphocytes and monocytes macrophages in Kawasaki disease. Clin Exp Immunol , Takegawa T, et alimmunoglobulin G1 allotypes in intravenous immunoglobulin nonresponders of Kawasaki disease patients. The Bulletin of the Yamaguchi Medical Shoolin press 19Burns JC, et alinfliximab treatment for refractory Kawasaki syndrome. J Pediatr , Ueno Y, et althe effect of TNF modulators on NFB activation in cultured endothelial cells of coronary arteries and monocytesmacrophages in vitro. americanheart.orgpresenter.jhtml?identifier Chung ES, et alrandomized, doubleblind, placebocontrolled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor, in patients with moderatetosevere heart failure. Circulation , Kwon HJ, et alcase reports of heart failure after therapy with a tumor necrosis factor antagonist. Ann Intern Med , SarziPuttini P, et altnf, rheumatoid arthritis, and heart failurea rheumatological dilemma. Autoimmun Rev , Lee T, et alplasma prostaglandin E2 level in Kawasaki disease. Prostaglandins Leukot Essent Fatty Acids , Kajimoto M, et alenhancement of activated 1 integrin expression by prostaglandin E 2 via EP receptors in isolated human coronary arterial endothelial cellsimplication for the treatment of Kawasaki diasease. Inflamm Resin press 26Suzuki Y, et alantiinflammatory effect of 1, 25dihydroxyvitamin D 3 in human coronary arterial endothelial cellsimplication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biolin press
Natalia Taborda Vanegas. Doc. Sci. Student Immunovirology Group Universidad de Antioquia
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