ALF fill and seal machines for ampoules and vials
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1 ALF fill and seal machines for ampoules and vials
2 ALF the convincing line concept Output: Up to /h. The ALF series of machines meets all the prerequisites for modern ampoule production. The convincing line concept. Wide experience, state-of-the-art knowhow, highly developed engineering and Bosch quality new dimensions for dependability, economy and flexibility with easy operator control. The ALF series was configured in accordance with pathfinding, pharmaceutically compliant findings to provide a modern, ergonomic design that supplies the customer with maximum benefits. Decisive in this design is a basic machine that can be equipped and retrofitted with various equipment units. These include: In-process control system Closing station for vials Infeed and outfeed starwheel Laminar Flow hood Isolator version Work and production considerations: Easy operator control due to the slim, tidy, clearly laid-out construction. Easy cleaning. All machine functions can be overseen, controlled and operated from one position at the front. Clean Room compliance. Drive and production segments are clearly separated: worktop right through. Virtually tool-free size changeovers. Integrated testing technique, e.g. for ampoule neck control (add-on device). Laser sealing technique (add-on device). ALF with the add-on equipment: pre-gasflushing, post-gasflushing, closure gasflushing and automatic, loss-free in-process control. 2
3 One basic machine for various equipment units The ampoules are transferred directly from the sterilizing tunnel to the ALF infeed belt. Via a scroll conveyor and transfer wheel the ampoules reach the conveying system by means of which they are conducted through the work stations: gasflushing, filling, sealing. Each filling point controls individually contactless scanning of the ampoule necks "no ampoule no filling". The ampoule necks are precentred by the draw-off grippers, the ampoule tips are then grasped and fed into a collection container. During the sealing procedure post-gasflushing can take place. The filled and sealed ampoules are pushed virtually load-free into the outfeed magazine. Ampoule transfer wheel ALF with the add-on equipment: pre-gasflushing, post-gasflushing, closure gasflushing and automatic, loss-free in-process control. 3
4 Precision filling systems for all product properties Time-pressure fill system and in-process control. Time-pressure filling system. Rotary slide pumps. Time-pressure filling system: The Bosch time-pressure filling system is successfully used for a wide range of applications due to a multitude of advantages: Easy size changing with just a few lowcost parts. Pressure and temperature acquisition are located right at the filling point. Usable for all liquid products, especially advantageous for shear-sensitive products. All parts in contact with product are suitable for manual cleaning and sterilizing in an autoclave and for CIP/SIP. Rotary slide pumps: Bosch provides precision filling for parenteralia with its proven rotary slide pump. Product-conserving and drip-free filling to the highest degree of filling precision are ensured for a wide range of different properties. Bosch seal-free rotary slide pumps have easy vertical cleaning paths. Technical in the lead: 3-part: rotary slide valve, pump cylinder, pump piston. Seal free. Easy, vertical cleaning paths. CIP/SIP capability. Rotary slide pumps made of stainless steel and ceramic material. 4
5 Add-on devices, laser sealing technique Sealing ampoules by the laser technique. The energy required for preheating and drawing off the ampoule neck is generated by a CO 2 laser. The system provides a special advantage for ampoule fill and seal machines that are equipped with an Isolator. The laser unit is set up outside of the Clean Room A. In comparison to conventional sealing with gas and oxygen this system is practically particle-free, flow-free and produces considerably less heat. Due to this no elaborated extraction of heat in the preheating and draw-off station is required. Flame adjustment, which is dependent on the glass and is often very sensitive, is dispensed with. Due to storage of the adjustment data the settings are reproducible and at the same time a considerably faster and simpler size changeover results. Protective gasflushing prior to filling Filling station (standard) Inert gasflushing after filling Gasflushing during closing Laser sealing station 5
6 Add-on devices: in-process control, double outfeed Discharge of containers into a tray for in-process control. Automatically switchable double outfeed. Discharge of containers into a tray for in-process control. Fully automatic, loss-free in-process control of the filling weight. Fully automatic in-process control, weighing position. Fully automatic in-process control, Touchscreen PC. 6
7 Add-on devices: sealing station for vials On the version of the processing of both ampoules and vials the 4-point and 6-point basic ALF machines can be equipped (and retrofitted) for different size and output ranges. ALF multi-purpose machine for ampoules and vials: right-angled outfeed via scroll conveyor. ALF multi-purpose machine, linear outfeed via scroll conveyor. CIP/SIP time-pressure filling station, SIP gasflushing stations. Product containers with min./max. control unit mounted on the distribution pipe. 7
8 Right-angled feed and discharge conveyors, wall installation, gasflushing ALF multi-purpose machine, right-angled outfeed scroll conveyor Feed star (with right-angled arrangement of the sterilizing tunnel and on the multipurpose machine). Right-angled discharge conveyor Wall installation Gas installation package 8
9 Size parts Size set for standard machine. Sizepart set for infeed, with tunnel installed at right angle. Size set for right-angled outfeed Size set for IPK. 9
10 Bosch is number 1 worldwide in Isolator engineering The leading pharmaceutical companies have set themselves the objective of marketing innovative products, which is why they back Bosch s innovative Isolator engineering. In the pharmaceuticel industry Isolator technology is gaining ever greater importance due to its clear production advantages. Comparisons with conventional sterile room technology have been dealt with in a multitude of technical articles and symposia. There is a clear trend towards the Isolator technique. The advantages of personnel and product protection are what makes isolators the technology of the future. Bosch has proven its leading position because it has the largest share of the total number of Isolator installations supplied. Slim construction. Example of a compact ampoule installation with separately standing ventilation unit. 10
11 Ampoule compact line 11
12 Technical specifications Containers, machine type, container size, output: Type Vol. (ml) Ø (mm) H (mm) Adjusted throughput Ampoules ALF ml: 200/min ALF ml: 300/min ALF , ml: 400/min Ampoules ALF R - 30 R R: 200/min and combi 5H - 30H 5H: 180/min vials ALF R - 30 R R: 300/min combi 5H - 30 H 5H: 270/min Graphic illustrations in this leaflet are examples only! Determinant for the final execution, including technical specifications, is our individual quotation exclusively. Robert Bosch GmbH Packaging Technologie Division Pharma Business Unit Blaufelder Straße 45 D Crailsheim Postfach D Crailsheim Telephone Fax vt@boschpackaging.com Internet: Robert Bosch Ltda. Tecnologia de Embalagem Rua Dr. Rubens Gomes Bueno, São Paulo-SP/Brasil Telephone Fax vtbr@boschpackaging.com All dimensions in mm Subject to technical modifications. Bosch Packaging Technology K.K. Hatchobori NF Bldg., 4F , Hatchobori Chuo-ku Tokyo Japan Telephone Fax vtjp@boschpackaging.com Bosch Packaging Technology NA Pharmaceutical 8700 Wyoming Ave. N Minneapolis, MN USA Telephone Fax pharm-na@boschpackaging.com Internet: PA/ADV 03/04 1 E Arnold Deizisau Paper: white, without chlorine All rights reserved. IWF
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