TDA BEAUTY THAT GETS UNDER YOUR SKIN

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1 the Tda magazine TDA Transdermal Application Needleless BEAUTY THAT GETS UNDER YOUR SKIN THE CELLS ARE WHAT MATTERS Interview with Head of research & development Dr. Alexander Teslenko 1

2 CAN THE CELL ONLY THAT WHICH REACHES THE CELL EFFECT Die With an area of around two square meters and a weight of around ten kilograms, the skin is the largest organ of the human body. Below the upper levels of skin is the epidermis, which is difficult to penetrate. In order to achieve a sustainable revitalization of skin cells from outside, active agents have to penetrate to the cell cores. Until now, this was only possible with invasive therapies. With SEYO TDA, the deepest skin layers can successfully be treated without pain or risk. THE DREAM of eternal beauty Dr. Harmut Schwarze is a specialist for plastic and cosmetic surgery as well as for dermatology and venereology. The botox and facelift businesses are booming. Those searching for beauty undergo one painful surgical procedure after the other and often have to endure questionable cosmetic practices. Their enthusiasm for a perfect appearance represses the fact that these treatments come with a large risk to their health. And the result is often only temporary and comes not rarely without great cost to one s facial expression. Smooth skin without a scalpel? From a dermatological perspective, we only have the possibility of working directly on cell ageing. And this is easier said than done because everything that is applied on the surface of the skin only has limited effects on lower-lying regions like the dermis. Some creams can make the skin feel better to the touch, and perfumes can transport the impression of freshness, but the ageing process cannot be stopped. The SEYO TDA Beauty System is different. It reaches cellular structures and not only provides them with important active ingredients, but it also contributes to improved oxygenation with a long-lasting effect, all without needles and without pain. Taking the current degree of scientific development into account, SEYO TDA is a highly efficient, non-invasive form of therapy for regenerative skin treatment Meddrop GmbH Wilhelm-Stein-Weg Hamburg info@seyo.de 3

3 BEAUTY THAT GETS UNDER YOUR SKIN Beautiful skin is not a question of age. With SEYO TDA, there is now an anti-aging therapy that tightens skin sustainably, without needles of any kind. TDA stands for transdermal application, and so represents the world s first dermatologicalaesthetical therapy system that transports anti-aging active ingredients into the deepest skin layers non-invasively. 1. SEYO offers treatment programs adjusted for different skin types. 2. Treatment begins with SEYO CELL precision dermabrasion. 3. Using the TDA device is intuitive and guides the users through different treatment areas. 4. Contact-free treatment refreshes the skin with a pleasant massage feeling. At the same time, the active agents are transported into deep skin areas. 5. The SEYO COVER face mask encourages additional collagen formation and ensures a pleasant end to the TDA Session. The treatment begins after a facial cleansing with the SEYO CELL dermabrasion. In this process, dead skin cells are removed gently and efficiently. The SEYO CELL dermabrasion supports the uptake of TDA active ingredients (e.g. hyaluron complexes) and activates collagen-forming cells. SEYO CELL prepares the skin optimally for the TDA deep treatment. This is tightly targeted at various skin layers. The TDA applicator is guided at a certain distance over the skin regions that are to be treated. The device displays the progress of treatment and signals when it is time to switch to other face areas. SEYO TDA works without direct skin contact and produces a light, pleasantly cool massaging pressure on the surface of the skin. SEYO facial masks are a relaxing end of treatment. They refresh and relax the skin and leave behind the feeling of intensively nourished skin. SEYO fundamentally readjusts the skin. It regenerates itself from the inside and regains its natural tautness. Regular TDA treatments create deposits in the deepest skin layers. These encourage cell division permanently and ensure sustainably improved skin appearance. A tightening of the natural structures of the skin can be seen, and the depth of wrinkles is reduced. At the same time, TDA reduces gravitational wrinkles and the skin gains freshness and youth. SEYO TDA is the result of comprehensive research and development and is at present the only regenerative, non-invasive form of therapy that makes it possible to nourish deep skin layers to their maximum. SEYO TDA is a quantum leap on the way to dermatological-cosmetic perfection. 4 5

4 Active ingredients are applied to the skin with the handy TDA applicator. While conventional cosmetic applications cannot penetrate the stratum corneum, TDA transports active ingredients into the deepest skin layers. MODE OF ACTION 1 The TDA carrier substance, enriched with active ingredients, is mixed with pure oxygen to micro-units in the TDA applicator. 2 These are applied to the skin at supersonic speeds in precise synchronization. 3 A METHOD TO SUCCESS The SEYO TDA System consists of a computer-guided application station, the handy applicator and SEYO TDA cartridges. Using SEYO TDA is intuitive and the processor guides the device to adapt itself to each treatment situation. Different programs are available depending on skin type and the age of the person to be treated. During application, the system informs the user via touchscreen of the remaining treatment time and the intensity of therapy, and guides the user through the process of treatment and the various application areas. SEYO TDA creates highly concentrated and especially pure oxygen out of the surrounding air. This is an essential part of treatment. The special barrier-breaking substances in the product are activated by the high oxygen partial pressure. This opens the skin in such a way that the active ingredients can pass through to the deep dermis. The result: SEYO regenerates the skin from within, and the skin regains its natural tautness. Deposits of the active ingredients are formed in addition to a regulation of the balance of free radicals and an improved supply of oxygen in the dermis. As a consequence cell nourishment is activated further, ensuring sustainably improved skin and visible tightening. TDA opens the upper skin layers and creates a gateway for a penetration of the skin by, for example, deep-working hyaluronic acid into the deepest skin layers. 4 After just a few treatments, deposits are created that sustainably encourage cell division and skin regeneration. 6 7

5 advertisement SEYO fundamentally readjusts the skin SEYO TDA represents a holistic approach to therapy. The success of the TDA system does not only come from its intelligent programming and medical origin: From the cleansing facial massage to the non-invasive TDA treatment to the cell-activating facial mask, SEYO treatment is a spa experience with deep effects. SEYO TDA offers anti-aging treatments for the different needs of normal, mature and irritated skin. SEYO TDA therapies lend themselves just as well to a quick treatment during a lunch break as to a relaxing treatment after work. SEYO CELL The SEYO CELL dermabrasion system allows a controlled removal of the upper layer of the skin (stratum corneum) thanks to its special sapphire-coated 3D treatment surface. This innovative but simple dermabrasion optimally prepares the skin for deep regenerative therapy. SEYO TDA CARTRIDGES There are a variety of active ingredients and products for different skin types and skin problems. The HYAL-N series provides a comprehensive range of treatments from a nurturing start for young skin to a deeper therapy for mature women over 45. Customers with difficult skin need not do without anti-aging treatments from SEYO. Our formulas are adjusted to the needs of inflamed and sensitive skin. SEYO COVER SEYO facial masks are the treatment s relaxing conclusion. They consist of two components that are combined shortly before use. After the TDA treatment, the SEYO facial mask refreshes and relaxes the skin further and leaves behind a feeling of well-nourished skin. SEYO COVER ensures that collagen formation is once again intensively encouraged. SEYO HOME SEYO HOME rounds out the various treatments at a cosmetics institute with a whole range of high-quality products for home use. The care series provides optimal support of the TDA therapy at home. The ingredients are based on innovative TDA formulas. FINALLY! online beauty booking 8 9

6 Dr. Alexander Teslenko has been researching therapies to penetrate the skin since the 1970s. He is now the head of research and development at SEYO and as such, leads research into sustainable beauty and a more healthy body. THE CELLS ARE WHAT MATTERS Dr. Teslenko, what are the biggest challenges in the fight against skin aging? Dr. Teslenko: It is always important to provide for the cells. Many cosmetics firms develop substances that create a temporary good feeling to the skin because they include synthetic greases like silicon. This covers the skin and feels good to the touch. The skin, however, is neither cared for nor maintained. Exactly the opposite happens: by sealing it off, the skin s breathing is hindered and the aging process is sped up. At SEYO, we always keep an eye on the regenerative aspects of skin care. When it comes to fighting skin aging, there s no getting around a combination of providing the skin with active ingredients and oxygen. For us, measurable and sustainable beauty is the goal, not short-term appearances. The key to beauty is in the skin? Dr. Teslenko: In a certain sense, yes. However, beauty is a relative term and in the end, you are only as beautiful as you feel. Having a holistic understanding of problem zones and the interrelations within an organism is important. At SEYO, we don t just combat hypoxia damaging to cell biology, but we also regulate free radicals and provide cells with essential nutrients. And this has a positive influence on the skin s regenerative power. It depends on getting the right mix? Dr. Teslenko: Yes and no -- successful cell therapy to rejuvenate the skin requires many different factors that we holistically handle with SEYO. SEYO is more than just a mix it s a set of progressive processes that influence each other and work exponentially as a compound. Our research has validated the regenerative power of SEYO in long- term studies. We were especially glad about the sustainability of the therapy s success, which demonstrates the inherent superiority of our concept. NETWORKED COMPETENCE In order to achieve the most wide-reaching results possible, the Arivine Pharma AG, SEYO s parent company, works closely with leading research institutions. Together, we regularly test the effectiveness of our substances and question the modes of action in clinical studies. Practical suitability is always in the foreground of our developments. In this way, SEYO did not only optimize the patented TDA technology for use in aesthetic cosmetics, but also perfected it with appropriate research partners. Universitätsklinikum Hamburg-Eppendorf UNIVERSITÄTSSPITAL BERN Schweizerische Eidgenossenschaft Confédération suisse Confederazione Svizzera Universität Zürich Confederazuin svizra 10 11

7 Unsere PROfessional Schulungen für Trainings Professionals Anja Lemke TDA Professional and SEYO institute director The transdermal application system is not only new and innovative but also uncomplicated to learn. In the SEYO Institute Alstertal in Hamburg, we regularly perform professional trainings with speakers who are practitioners themselves. In small groups, trainees get to know the device and how to use it, become familiar with various programs, perform test treatments and get information about the SEYO business model. You can develop your cosmetics institute into a certified anti-ageing center with SEYO s concept-based business model and the patented TDA technology. I have won over new customers and see my regulars more often with SEYO Kosmetik Parfümerie, Ulla Greweling, Gütersloh INCREASE YOUR BUSINESS SUCCESS WITH SEYO! Would you like to win over new customers and get your regulars to come in more often? Add value to your institute with SEYO s unique anti-aging innovation. The patented TDA technology was developed especially for the needs of exclusive cosmetics institutes and is already being used by hundreds of premium partners. BECOME A VERY IMPORTANT PARTNER Sustainable success is important to us at SEYO. This goes for our products as much as it does for our cooperation with cosmetics institutes. This is why we support our Very Important Partners with many all-inclusive features that make it easier to sell our products and treatments. Take the chance to professionalize the marketing and organization of your institute from the ground up with SEYO Partner packages. As a principle, working with SEYO means achieving higher prices per minute than with conventional treatments, and ensuring that even short sessions lead to high customer satisfaction. Many of my customers do not have enough time for an extensive anti-aging treatment. With SEYO, I can finally offer an effective short treatment in 20 minutes. It s perfect for a little beauty boost on one s lunch break. Schöngeist Wax & Beauty, Dorothea Malzkorn, Köln The TDA is easy to use. After a skin diagnosis, I choose the appropriate program. I am now a routine user and am always happy about the excellent results. Beauty Cosmetics, Babette Spielhagen, Potsdam The anti-aging technology from SEYO has given my business a real push. In the last month, I even hired another cosmetician. Kosmetikstudio, Petra Niehoff, Hamburg 12 13

8 OUR STANDARD IS EXCEPTIONAL Made in Germany is not just a designation of origin, but a qualitative standard for each step in our workflow Doing things differently It may be one of the secrets to our success that we attempt to combine apparently incongruous things in order to achieve the best results: young and old, specialist and generalist. For sure, our refusal to be content with our sector s usual procedures helped in the development and realization of the SEYO TDA system. We recognized that no unknown procedure, no bought - in manufacturing techniques and no outsourced product development would fulfill our standards and our customers expectations. That s why we do everything ourselves. We create new processes and leave well-worn paths, no matter if it s about the design and the optimization of the TDA device or the development of formulas with new active ingredients. At SEYO, our goal is not to push the latest of many promises of beauty onto the market with a lot of advertising, but to develop a scientifically grounded therapy against cellular skin aging. From the beginning. In every detail. From research to the development of all the system s parts to market roll-out. And what has not yet been invented, we develop. Beauty direct from the producers SEYO is part of Arivine Pharma AG, an innovative life sciences company based in Switzerland. Since the 1990s, Arivine scientists have been researching skin penetration applications and cooperate with university clinics as well as the Fraunhofer Institute for Microbiology. Patented TDA technology was originally developed for medical technology. In cooperation with dermatologists and cosmeticians, SEYO TDA was specially developed further for use in cosmetic institutes and dermatologist s offices

9 SUCCESS IN FIGURES TDA transports active ingredients as far as the deep dermis. Deposits of active ingredients are formed in addition to a regulation of the balance of free radicals and an improved supply of oxygen in the dermis. Scientific studies show: +60% skin moisture The ultrasound cross-section shows the thickness of the epidermis (between the lines). The SEYO carrier substance opens the epidermis at first contact and makes it possible to transport even large molecules in deep skin layers. THE STANDARD WITH +65% SEYO OPENING THE EPIDERMIS An investigation of the skin appearance of 32 female test persons (after 6 treatments within 6 weeks) show: within a very short amount of time, aged skin had been smoothed by up to 166% with TDA treatments. +166% smoother Crow s feet +132% smoother corners of the mouth IMPROVED SKIN +54% smoother Forehead OXYGEN SUPPLY +62% OXYGEN SUPPLY A sensor-based investigation of oxygen transport shows that SEYO makes it possible to deeply replenish the cells, to regulate molecular polarity and to prepare the cells optimally to take up active ingredients. The speed of regeneration can be measurably increased. -85% FREE RADICALS TRANSPORT INTO THE DEEP THE STANDARD WITH SEYO x6 An investigation with phosphoric substances and human skin shows that while leading hyaluron formulas are not able to penetrate even the uppermost layer of the epidermis, the hyaluric acid administered with SEYO penetrates the epidermis and reaches the deep dermis with long-lasting availability

10 Do you have a cosmetics institute and would like to learn more about your chances for business success? While developing the SEYO TDA system, we have paid attention to not only fulfilling our scientific standards, but also ensuring that the system be usable in cosmetics institutes. A treatment concept fulfilling every possible wish in terms of quality, design, user friendliness, ease of use and a range of services has been developed in cooperation with experienced dermatologists and certified cosmeticians. With the innovative TDA system, SEYO supports you in expanding your range of beauty services. Several hundred cosmetics institutes already rely on SEYO. This unique technology, sophisticated programming and easy use generate added value as if by the push of a button. Treat your skin like a VIP We are happy to provide additional information about our attractive financing and leasing models as well as the comprehensive TDA starter package including product and marketing trainings. At the same time we would like to invite you to visit us. Experience SEYO, try TDA for yourself and meet our experts! 18 Meddrop GmbH Wilhelm-Stein-Weg Hamburg info@seyo.de 19

11 20 Treat your skin like a VIP