Publications 1. Chen WT, Liang DR, Hus GR et al. Colonic Endometriosis of the Rectum Mimicking Colon Cancer- A Case Report JS CRS ROC 1995; 6:

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1 William T. Chen, MD Date of Birth: June 11, , Yuh Der Road, Taichung City, 404, Taiwan TEL: ext FAX: Education China Medical University, School of Medicine Taichung, Taiwan Doctor of Medicine, June, 1990 Licensure Current Position Society National Board of Medicine of Taiwan Board certified, Taiwan Surgical Society Board certified, Society of Colon and Rectal Surgeons, Taiwan Board certified, Taiwan Surgical Society of Gastroenterology Board certified, Taiwan Society of Endoscopic Surgery Vice-Superintendent, International Medicine Center China Medical University Hospital, Taichung City, Taiwan Chairman, Department of Surgery China Medical University Hospital, Taichung City, Taiwan Director, Minimally Invasive Center China Medical University Hospital, Taichung City, Taiwan Assistant Professor of Surgery College of Medicine China Medical University, Taichung City, Taiwan Member, American Society of Colon and Rectal Surgeons Member, Society of American Gastrointestinal Endoscopic Surgeons Board Member, Endo-laparoscopic Surgeons of Asia Board Member, Asia-Pacific Endo-laparoscopic Surgeons Board Member, Asian Endoscopic Task Force

2 Publications 1. Chen WT, Liang DR, Hus GR et al. Colonic Endometriosis of the Rectum Mimicking Colon Cancer- A Case Report JS CRS ROC 1995; 6: Chen WT, Chen MC, Chen HC et al. Colonic Cystic Lymphangioma and Retroperitoneum Cyst JS CRS ROC, 3. Chen WT, Chen HC, Chui CM et al. Laparoscopic Resection of Colorectal Cancer- Formosan J Surg 2000; 33: Chen MC, Chen WT, Huang DM Leiomyoma of Rectum-Report of A Case JS CRS ROC 1998;9: Zhao R, Baig MK, Wexner SD, Chen W et al Enterochromaffin and Serotonin Cells are abnormal for patients with colonic inertia. Dis Colon Rectum 2000;43: Chen WT, Chen HC, Chui CM et al. Laparoscopic Resection of Colorectal Cancer- Formosan J Surg 2000; 33: Chen HC, Chen WT, Chui CM et al. Laparoscopic Abdominoperineal Resection- Chang-Hua Christian Hospital Experience- JS CRS ROC 2000, JS CRS ROC 2000;11: Yeh MH, Huang DM, Chen WT et al. Management of Iatrogenic Colonoscopic Perforation JS CRS ROC 2000;11: Pikarsky AJ, Saida Y, Yamaguchi T, Martinez S, Chen W, Weiss EG, Nogueras JJ, Wexner SD. Is obesity a high-risk factor for laparoscopic colorectal surgery? Surg Endosc 2002 May;16(5): You JJ, Chen WT, Huang TM, Yeh KT, Yang AD Huge outgrowing perineal leiomyoma J Soc Colon Rectal Surgeon ( Taiwan ) 2003;14: Hsiao KH, Chen WT, Huang TM Obstructed Small Cell Carcinoma of The Rectum- A Case Report and Literature Review J Soc Colon Rectal Surgeon ( Taiwan ) 2003;14: Lin SY, KT Yeh, Chen WT, et al. Promoter CPG methylation of tumor supporessor genes in colorectal cncer and its relationship to clinical features Oncology Reports 11: , Lin SY, KT Yeh, Chen WT, et al. Promoter CPG Methylation of Caveolin-1 in Sporadic Colorectal Cancer Anticancer research 2004;24: You JJ, Chang TH, Chung CY, Chen WT, Chang CS, Liu MT, Hsiao KH, Chen HC, Huang TM Preoperative weekly 24-hour infusion of high-dose 5-fluorouracil and leucovorin (HDFL) with concurrent radiation for T3, T4 rectal cancer on an outpatient basis J Soc Colon Re ctal Surgeon (Taiwan) 2005;16: Lam CW, Chen WT, Liu MT, Chang CS, Huang TM, Hsu GH, Chen HC, Hsiao KH, Chiu CM, You JJ Effect of preoperative concurrent chemoradiotherapy in locally advanced low rectal cancer after radical resecton surgery Int Surg 2005:90: Hwang KL, Chen WTL, Hsiao KH, Chen HC, Huang TM, Chiu CM, Hsu GH.A prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation World J Gastroenterol 2005;11(47): Lin TC, Chen WT, Chen HC, Hsiao KH, You JJ, Kei TW, Huang TM Laparoscopic low anterior resection for selective mid and low rectal cancer J Soc Colon Rectal

3 Surgeon ( Taiwan ) 2006;17: Tsai MF, Chen WT, Huang TM et al Clinical Application of Defecography in Patients with Difficulty Defecation J Soc Colon Rectal Surgeon ( Taiwan ) 2006; 17: Huang HY, Chen WT, Hsu LS, You JJ, Huang TM, Chen HC, Lin TC, Chen YH APC Gene Mutations in Familial Adenomatous Polyposis: A Four Family Analysis J Soc Colon Rectal Surgeon (Taiwan) 2007;18: Ke TW, Chen WT, Chen HC, Huang TM, You JJ, Lin TC Laparoscopic Abdominoperineal Resection for Low Rectal Adenocarcinoma J Soc Colon Rectal Surgeon (Taiwan) 2008;19: Chien CR, Chen SW, Chen WT Radiation fields of neoadjuvant concurrent chemoradiotherapy for rectal cancer: in regard to Yu et al. Int J Radiat Oncol Biol Phys 2008;71: Chiang HC, Ting WC, Chen WT The Role of Colonic Stents in Obstructive Metastic Colorectal Cancers J Soc Colon Rectal surgeon ( Taiwan ) 2009 Mar;20: Hsu WY, Chen WT, Lin WD, Analysis of urinary nucleosides as potential tumor markers in human colorectal cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry. Clin Chim Acta Apr;402(1-2):31-7. Epub 2008 Dec Chiang HC, Chen WT, Wu C Laparoscopic-assisted Versus Open surgery for Rectal Cancer. J Soc Colon Rectal surgeon ( Taiwan ) 2010 Jun;21: Chang SC, Ke TW, Chiang HC, Wu C, Chen WT Laparoscopic Excision is an Alternative Method for Rectal Gastrointestinal Stromal Tumor Surg Laparosc Endosc Percutan Tech 2010 Aug;20(4): Chen WT, Chang SC, Ke TW, Identification of biomarkers to improve diagnostic sensitivity of sporadic colorectal cancer in patients with low preoperative serum carcinoembryonic antigen by clinical proteomic analysis Clin Chim Acta Dec 24. [Epub ahead of print] 27. Chang SC, Ke TW, Chiang HC, Wu C, Chen WT. Laparoscopic excision is an alterative method for rectal gastrointestinal stromal tumor. Surg Laparosc Endosc Percutan Tech Aug;20(4): Chen WT, Chang SC, Ke TW, Chiang HC, Tsai FJ, Lo WY. Identification of biomarkers to improve diagnostic sensitivity of sporadic colorectal cancer in patients with low preoperative serum carcinoembryonic antigen by clinical proteomic analysis. Clin Chim Acta Mar 18;412(7-8): Chen WT, Chang, Chiang HC, Lo Wy, Jeg LB, Wu C, Ke Tw. Single incision laparoscopic versus conventional laparoscopic right hemicolectomy: a comparison of short-term surgical results. Surg Endosc Jun;25(6): Fang HY, Jan CI, Chen CK, Chen WT. Catamenial pneumothorax due to bilateral pulmonary endometriosis. Respir Care Jul; 57(7): Chen YY, Ke TW, Chen WT. Acute gastric outlet obstruction after left hemicolectomy. Gastroenterology Nov;143(5):e Lu YY, Chen JH, Chien CR, Chen WT, Tsai SC, Lin WY, Kao CH. Use of FDG- PET or PET/CT to detet recurrent colorectal cancer in patients with elevated CEA: A systematic review and meta-analysis. Int J colorectal Dis Aug;28(8):

4 33. Chen SW, Chen WT, Wu YC, Yen KY, Hsieh TC, Lin TY, Kao CH, Which FDG/PET parameters of the primary tumor in colon or sigmoid cancer provide the best correlation with the pathological finding? Eur J Radiol Sep: 82(9): e Lo Wy, Jeng LB, Lai CC, Tsai FJ, Lin CT, Chen WT. Urinary cytidine as an adjunct biomarker to imp;rove the diagnostic ration for gastric cancer in Taiwanese patients. Clin Chim ACta Jan 20; 428: Hsiao CW, Huang WY, Ke TW, Muo CH, Chen WT, Sung FC, Kao CH Association between irritable bowel syndrome and colorectal cancer: a nationwide populationbased study. Eur J Intern Med Jan;25 (1): Laio Cy, Chen SW, Wu YC, Chen WT, Yen KY, Hsieh TC Chen PJ, Kao CH. Correlations between 18F-FDG PET/CT parameters and pathological findings in patients with rectal cancer. Clin Nucl Med Jan;39(1): e Wang LW, Hsiao CF, Chen WT, Lee HH, Lin TC, Chen HC, Chen HH, Chien CR Lin TY, Liu TW. Celecoxib plus chemoradiotherapy for locally advanced rectal cancer: a phase II TCOG study. J Surg oncol May; 109(6): Ke TW, Liao YM, Chiang HC, Chang SC, Wang PH, Chen YY, Chen WT, Chien CR. Effectiveness of neoadjuvant concurrent chemoradiotherapy versus up-front proctectomy in clinical stage II-III rectal cancer: A population-based study. Asia Pac J Clin Oncol Jan 24. Doi: /ajco [Epub ahead of proint] PubMed PMID: Ke TW, Hsu HL, Wu YH, Chen WT, Chen YW Cheng CW. MicroRNA-224 suppresses colorectal cancer cell migration oby targeting Cdc42. Dis Markers. 2014;2014: Doi: /2014/ Epub 2014 Apr 10. PubMed PMID: ; PubMed Central PMCID: PMC Ramireddy L. Chen WT, Peng CT, Hu RM, Ke TW, Chiang HC, Chang SC Tsai FJ, Lo WY. Association Between Genetic Polymorphism of the MIF Gene and Colorectal Cancer in Taiwan. J Clin Lab Anal May 19. Dio: /jcla [Epub ahead of print] PubMed PMID: Liu CY, Chen WT, Kung, PT, Chiu CF, Wang YH, Shieh SH, Tsai WC. Characteristics, survival, and related factors of newly diagnosed colorectal cancer patients refusing cancer treatments under a universal health insurance program. BMC Cancer. 2014Jun 17; 14: Chen WT, Ke TW, Li CC, Chien CR. Questionable role of adjuvant chemotherapy in rectal cancer patients who had reached pathological complete resepose agter neoadjuvant concurrent chemoradiotherpay: no matter in the East or in the West J Cancer Res Clin Oncol Jun 24. [ Epub ahead of print ] PubMed PMID; Chen SW, Chiang HC, Chen WT, Hsieh TC, Yen, KY, Chiang SF, Kao CH. Correlation Between PET/CT Parameters and KRAS Expression in Colorectal Cancer. Clin Nucl Med Aug;39(8): Chen WT, Yang TS, Chen HH, Chen HH, Chiang HC, Lin TC, Yeh CH Ke TW, Chen JS, Hsiao KH, Kuo ML Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer Nutr Res Jul;34(7): doi: /j.nutres Epub 2014 Jun Ke TW, Wei PL, Yeh KT, Chen WT, Cheng YW. MiR-92a Promotes Cell

5 Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway Ann Surg Oncol Dec 17. [Epub ahead of print] 46. Ke TW, Wei PL, Yeh KT, Chen WT, Cheng YW. MiR-92a Promotes Cell Metastasis of Colorectal cancer Through PTEN-Mediated PI3K/AKT Pathway Ann Surg Oncol Aug;22(8): doi: /s Epub 2014 Dec Wu SC, Chen WT, Muo CH, Ke TW, Fang CW, Sung FC. Association between appendectomy and subsequent colorectal cancer development: an Asian population study PLoS One Feb 24;10(2):e doi: /journal.pone ecollection Wu SC, Chen WT, Muo CH, Sung FC. Appendicitis as an early manifestation of subsequent malignancy: an Asian population study. PLoS One Apr 27;10(4):e doi: /journal.pone ecollection Wu SC, Chen WT, Lin HH, Fu CY, Wang YC, Lo HC, Cheng HT, Tzeng CW. Use of extracorporeal membrane oxygenation in severe traumatic lung injury with respiratory failure Am J Emerg Med May;33(5): doi: /j.ajem Epub 2015 Feb Chen WT, Ke TW, Liao YM, Li CC, Chien CR. Optimal interval of surgery after neoadjuvant radochemotherapy in T3-4/N0+ rectal cancer: population level evidence in addition to controlled trial J Gastrointest Oncol Jun;6(3):E38-9. doi: /j.issn No abstract available. 51. Chang YC, Chang JG, Liu TC, Lin CY, Yang SF, Ho CM, Chen WT, Chang YS. Mutation analysis of 13 driver genes of colorectal cancer-related pathways in Taiwanese patients World J Gastroenterol Feb 21;22(7): doi: /wjg.v22.i Chien CR, Chen WT, Wang HM, Lin CH, Li CC Modulated radiotherapy in neoadjuvant concurrent chemoradiotherapy for locally advanced rectal cancer Dis Colon Rectum 2016 Jun;59(6):e401. doi: /DCR

6 Biography of William Tzu-Liang Chen Dr. William Tzu-Liang Chen is currently the Chief of Department of Surgery at his Alma Mater, China Medical University in Taichung. After earning his medical degree in Taiwan, he completed a research fellowship in colorectal surgery at the Cleveland Clinic in Florida. Utilizing his training and clinical experiences, he has made notable contributions to literature regarding cutting edge techniques of minimally invasive surgery for treating colorectal diseases. Dr. Chen is also a charismatic speaker who has been invited to present at over 50 international conferences. Along with serving as a practitioner and researcher, Dr. Chen enjoys his position as an assistant professor in the Department of Surgery at China Medical University.