: Biology PhD course, University of Debrecen, Hungary : BSc, software engineering, University of Debrecen, Hungary

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1 Personal details Name: Position: Viktória Lázár (PhD) Postdoctoral researcher, Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Temesvári krt. 62., Szeged, Hungary, H Education : Biology PhD course, University of Debrecen, Hungary : BSc, software engineering, University of Debrecen, Hungary : MSc, specialized in molecular biology and genetics, University of Debrecen, Hungary Research experience present: Postdoctoral Research Fellow, Evolutionary Systems Biology Group, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences (Szeged,Hungary) : Research associate, Evolutionary Systems Biology Group, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences (Szeged,Hungary) PI: Dr. Csaba Pál : PhD student, Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Hungary, Thesis: Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation, PI: Prof. Margit Balázs : ERASMUS student, King s College London, Department of Life Sciences,London,UK, Mentor: Dr. Stuart Knight : MSc student, Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Hungary Thesis: Study of the oncogenes in human breast cancer cells induced in SCID mouse with fluorescence in situ hybridization and comparative genomic hybridization. PI: Prof. Margit Balázs 1

2 Scientific awards and grants Postdoctoral fellowship given by the Hungarian Academy of Sciences September September The first EMBO poster price for outstanding scientific accomplishments. Microbiology after the genomics revolution: Genomes 2014, Június 24-27, 2014, Paris, France Young Investigator Award of the Hungarian Academy of Sciences First price of an article contest of the Qualitas Biologica Foundation. Hungary, 2014 January 24. The first poster price for outstanding scientific accomplishments. GRC Drug Resistance Conference, 29 July-3 August 2012, Stonehill College in Easton, MA US National scholarship for outstanding students given by the Hungarian Ministry of Education.(2004 September June) ERASMUS studentship to perform research at the Department of Life Sciences of King s College, London, UK (2004 September February) Invited Lectures FEMS Microbiology Conference (2013 July 21-25, Leipzig, Germany), Bacterial evolution of antibiotic hypersensitivity FRISBI seminar of the IST institute, Bollenbach s research group( 2013 December 6, Vienna, Austria), Genome-wide analyses of the cross-resistance interaction network Seminar of the Hibbett lab at the Clark University (2012 July 12, Worcester, MA, US), The cross-resistance network illuminates the evolution of antibiotic hypersensitivity János Bolyai Applied Mathematics Conference, (2012 June 21-23, Győr, Hungary), Automated mapping of antibiotic interactions in Escherichia coli, Modelling in Life Sciences, (2011 November 3-5, Szeged, Hungary), Automated mapping of antibiotic interactions in Escherichia coli Teaching and mentoring activities present: Systems Biology Course for BSc/MSc and PhD students, University of Szeged, Hungary 2

3 : Biochemitry Course, Department of Life Sciences, King s College, London, UK : Physiology Course, University of Debrecen, Hungary Conference attendance Lázár V., Singh GP., Nagy I., Spohn R., Horváth B., Hrtyan M., Busa-Fekete R., Bogos B., Méhi O., Csörgő B., Pósfai Gy., Fekete G., Szappanos B., Kégl B., Pál Cs. & Papp B. Bacterial evolution of antibiotic hypersensitivity; Annual meeting of the Society for Molecular Biology and Evolution (Smbe), July 2015, Vienna, Austria (oral presentation) Lázár V., Singh GP., Nagy I., Spohn R., Horváth B., Hrtyan M., Busa-Fekete R., Bogos B., Méhi O., Csörgő B., Pósfai Gy., Fekete G., Szappanos B., Kégl B., Pál Cs. & Papp B. Bacterial evolution of antibiotic hypersensitivity; ICETAR 2015: International Conference on the Evolution and Transfer of Antibiotic Resistance, June 2015, Amsterdam, The Netherlands (oral presentation) Lázár V., Pál Cs. & Papp B. Cross resistance of multidrug resistant bacteria to antimicrobial peptides; 2015 "Antimicrobial Peptides" Gordon Research Conference. Május , Lucca (Barga), Italy (poster) Lázár V., Pál Cs. & Papp B. Genome-wide analysis unravels the determinants of the antibiotic cross-resistance interaction network; Microbiology after the genomics revolution: Genomes 2014, Június 24-27, 2014 Paris, France (poster) Evolution of antibiotic hypersensitivity; 1st ASM Conference on Experimental Microbial Evolution, Június , Washington, DC, USA (poster) Evolution of antibiotic hypersensitivity; FEMS Microbiology Conference, July , Leipzig, Germany (oral presentation) Evolution of antibiotic hypersensitivity. New Approaches and Concepts in Microbiology, October , EMBL Heidelberg, Germany (poster) Exploring the network of antibiotic cross-resistance and collateral sensitivity interactions during bacterial evolution GRC Drug Resistance Conference, 29 July-3 August 2012, Stonehill College in Easton, MA US (poster) 3

4 Exploring the network of antibiotic cross-resistance and collateral sensitivity interactions during bacterial evolution. SfAM Summer Conference, 2-5 July 2012, Edinburgh, Scotland, UK (poster) Lázár V., Busa-Fekete R., Fekete G., Singh GP., Kégl B., Pál Cs. & Papp B. Automated mapping of antibiotic interactions in Escherichia coli; János Bolyai Applied Mathematics Conference, Június 2012, Győr, Hungary (oral presentation) Lázár V., Busa-Fekete R., Fekete G., Singh GP., Kégl B., Pál Cs. & Papp B. Exploring the network of antibiotic cross-resistance and collateral sensitivity interactions during bacterial evolution, Genetikai műhelyek Magyarországon, Szeptember14. Szeged, Magyarország (oral presentation) Lázár V., Busa-Fekete R., Fekete G., Singh GP., Kégl B., Pál Cs. & Papp B. Automated mapping of antibiotic interactions in Escherichia coli; Modelling in Life Sciences, 3-5 November 2011, Szeged, Magyarország (oral presentation) Lázár V., Busa-Fekete R., Fekete G., Singh GP., Kégl B., Pál Cs. & Papp B. Automated mapping of antibiotic interactions in Escherichia coli. IX. Hungarian Congress of Genetics and XVI. Days of Cell and Developmental Biology, March 2011, Siófok, Hungary (poster) Lázár V., Ecsedi Sz., Rákosy Zs., Tóth R., Szöllősi A., Emri G., Ádány R., Balázs M.: Characterization of cyclin D1 and other candidate gene amplification in the 11q13 region in human primary melanoma; ISAC XXIV. International Congress: Cytometry in the Age of Systems Biology, May, 2008, Budapest, Hungary (poster) Lázár V., Ecsedi Sz., Rákosy Zs., Tóth R., Szöllősi A., Emri G., Ádány R., Balázs M.: Characterization of cyclin D1 and other candidate gene amplification in the 11q13 region in human primary melanoma; ISAC XXIV. International Congress: Cytometry in the Age of Systems Biology, May, 2008, Budapest, Hungary (poster) Lázár V., Balázs M., Rákosy Zs., Vízkeleti L., Ecsedi Sz., Bégány Á., Ádány R.: Characterization of human primary melanomas using array comparative genomic hybridization; Ph.D. and TDK Conference, University of Debrecen, Medical and Health Science Center, February, 2007., Debrecen, Hungary (oral presentation) Publications Pál C, Papp B, Lázár V. Collateral sensitivity of antibiotic-resistant microbes. TRENDS MICROBIOL. In Press. Corrected Proof. 03/2015. IF: 9.81 Lázár V, Nagy I, Spohn R, Csörgő B, Györkei Á, Nyerges Á, Horváth B, Vörös A, Busa- Fekete R, Hrtyan M, Bogos B, Méhi O, Fekete G, Szappanos B, Kégl B, Papp B, Pál C. Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network. NATURE COMMUNICATIONS. 5: Paper p. (2014). IF:

5 Notebaart RA, Szappanos B, Kintses B, Pál F, Györkei Á, Bogos B, Lázár V, Spohn R, Csörgő B, Wagner A, Ruppin E, Pál C, Papp B. Network-level architecture and the evolutionary potential of underground metabolism. PROC. NATL. ACAD. U S A. 111: (32) pp (2014). IF: 9.81 Ocampo PS, Lázár V, Papp B, Arnoldini M, Abel zur Wiesch P, Busa-Fekete R, Fekete G, Pál C, Ackermann M, Bonhoeffer S. Antagonism between bacteriostatic and bactericidal antibiotics is prevalent. ANTIMICROB. AGENTS CHEMOTER. 58:(8) pp (2014). IF: 4.45 Szamecz B, Boross G, Kalapis D, Kovács K, Fekete G, Farkas Z, Lázár V, Hrtyan M, Kemmeren P, Groot Koerkamp MJ, Rutkai E, Holstege FC, Papp B, Pál C. The genomic landscape of compensatory evolution. PLOS BIOL. 12:(8) Paper e p. (2014). IF: Ecsedi S, Hernandez-Vargas H, Lima SC, Vizkeleti L, Toth R, Lazar V, Koroknai V, Kiss T, Emri G, Herceg Z, Adany R, Balazs M. DNA methylation characteristics of primary melanomas with distinct biological behaviour. PLOS ONE. 05/2014. IF: 3.53 Lázár V, Singh GP, Spohn R, Nagy I, Horváth B, Hrtyan M, Busa-Fekete R, Bogos B, Méhi O, Csörgő B, Pósfai Gy, Fekete G, Szappanos B, Kégl B, Papp B & Pál Cs Bacterial evolution of antibiotic hypersensitivity MOLECULAR SYSTEMS BIOLOGY 9:700 (2013). IF: Lázár V. Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation MAGYAR ONKOLÓGIA Jun;57(2):96-9. Hungarian. IF:- Rakosy Z, Ecsedi S, Toth R, Vizkeleti L, Hernandez-Vargas H, Lazar V, Emri G, Szatmari I, Herceg Z, Adany R, Balazs M Integrative genomics identifies gene signature associated with melanoma ulceration. PLOS ONE 8:(1) p. e (2013) IF: Lázár V, Ecsedi Sz, Vízkeleti Laura, Rákosy Zs, Boross G, Szappanos B, Bégány Á, Emri G, Ádány R, Balázs M Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization MELANOMA RESEARCH 22: pp (2012) IF: Vizkeleti L, Ecsedi S, Rakosy Z, Orosz A, Lazar V, Emri G, Koroknai V, Kiss T, Adany R, Balazs M The role of CCND1 alterations during the progression of cutaneous malignant melanoma TUMOR BIOLOGY 33:(6) pp (2012) IF: Barok M, Balázs M, Lázár V, Rákosy Zs, Tóth E, Treszl A, Vereb G, Colbern G T, Park J W, Szőllősi J Characterization of a novel, trastuzumab resistant human breast cancer cell line FRONTIERS IN BIOSCIENCE 1:(2) pp (2010) IF: Lázár V, Ecsedi S, Szöllősi A G, Tóth R, Vízkeleti L, Rákosy Z, Bégány A, Ádány R, Balázs M Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma MODERN PATHOLOGY 22: pp (2009) IF: