outline What is a stem cell? Tissue stem cell Embryonic stem cell ips cell -production -advantages Applications Issue Conclusion

Size: px
Start display at page:

Download "outline What is a stem cell? Tissue stem cell Embryonic stem cell ips cell -production -advantages Applications Issue Conclusion"

Transcription

1 outline What is a stem cell? Tissue stem cell Embryonic stem cell ips cell -production -advantages Applications Issue Conclusion 1

2 What is a stem cell? Definition: Self-renew themselves a number of times Differentiate into many types of cells embryonic stem cell Blastocyst (early embryo) 2

3 Properties of a stem cell Self-renew Identical stem cell Differentiate into specialized cells Specialized cell 3

4 Types of stem cells Tissue stem cell Embryonic stem cell ( ES ) Induced pluripotent stem cell ( ips ) Shinya Yamanaka 山中伸彌 2012 The Nobel Prize in Physiology or Medicine 4

5 Tissue stem cell (adult somatic stem cell) Many kinds of tissue stem cells are in our bodies Renew a number of times but not indefinitely Multipotent can make certain types of specialized cells differentiate blood stem cell only certain types of blood cell: red blood cells, white blood cells etc. 5

6 Embryonic stem cell (ES) Derived from a blastocyst Self-renew indefinitely Pluripotent can make almost all types of specialized cells Can be used to treat diseases 6

7 Therapy with ES Problems: Ethical concerns Immune rejection May cause tumor 7

8 ips cell A type of pluripotent stem cell Artificially derived from a somatic cell by inducing a "forced" expression of certain genes. First produced in 2006 from mouse cells and in 2007 from human cells. 8

9 How to make an ips cell? biopsy genetic reprogramming (add certain genes to the cell) adult somatic cell ips cell behaves like an embryonic stem cell four important genes in embryonic stem cells: Oct-3/4, SOX2, c-myc, and Klf4. 9

10 Therapy with ips 1)Take somatic cells from the patient (like skin cells) 2)Make ips cells (no need for embryos) 3)Use those ips cells to grow the specialized cells the patient needs to recover from the disease 10

11 Advantages of ips cells It s easy to get somatic cells from human bodies. No ethical problems No immune rejection 11

12 Applications Test drugs in the laboratory Study how diseases develop (disease modeling) Organs creating (mouse kidneys) Regenerative medicine (developing treatment for Parkinson s, diabetes, anemia) 12

13 Flowchart - regenerative medicine ( Sickle cell anemia) 13

14 Issues Because of the used gene c-myc,the created cells might be prone to form tumors. (20% of the mice developed cancer.) The process of creating ips without c-myc, takes longer and is not as efficient, but the resulting mice didn't develop cancer. 14

15 Conclusion ips vs ES - Easy to get somatic cells - No ethical problems - No immune rejection The gene c-myc might be prone to form tumors Application - Drug development - Organs transplantation (potential) - Regenerative medicine 15

16 Reference Euro stem cell : Yamanaka S. & et al. ; Generation of germlinecompetent induced pluripotent stem cells, Nature 2007;448: Takahashi & K. Yamanaka; Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell 2006;126:

Stem Cells: Introduction and Prospects in Medicine

Stem Cells: Introduction and Prospects in Medicine Stem Cells: Introduction and Prospects in Medicine Bioscience in the 21 st Century Ware, 2011 www.gothamgazette.com/.../stemcell/stem_cell.jpg Overview Setting the stage for a discussion about tissue engineering:

More information

Stem Cells: Introduction and Prospects in Medicine.

Stem Cells: Introduction and Prospects in Medicine. Stem Cells: Introduction and Prospects in Medicine www.gothamgazette.com/.../stemcell/stem_cell.jpg Ode to a Stem Cell, Part II by VCW There once was stem cell stuck in the hood Dividing endlessly, but

More information

Stem Cells: Introduction and Prospects in Medicine.

Stem Cells: Introduction and Prospects in Medicine. Stem Cells: Introduction and Prospects in Medicine www.gothamgazette.com/.../stemcell/stem_cell.jpg Overview Setting the stage for the discussion: historical perspective and prospects in regenerative medicine

More information

Stem Cells: Introduction and Prospects in Medicine Professor Vassie Ware, 2012 Department of Biological Sciences

Stem Cells: Introduction and Prospects in Medicine Professor Vassie Ware, 2012 Department of Biological Sciences Stem Cells: Introduction and Prospects in Medicine Professor Vassie Ware, 2012 Department of Biological Sciences www.gothamgazette.com/.../stemcell/stem_cell.jpg Overview What s the Big Deal? A Historical

More information

Bioscience in the 21 st Century

Bioscience in the 21 st Century Stem Cells: Introduction and Prospects in Medicine Bioscience in the 21 st Century Ware, 2010 www.gothamgazette.com/.../stemcell/stem_cell.jpg Overview Setting the stage for a discussion about tissue engineering:

More information

Reprogramming, Pluripotency and Differentiation

Reprogramming, Pluripotency and Differentiation STEM CELL BIOLOGY Reprogramming, Pluripotency and Differentiation 1 Outline - Background - Applications of stem cell research - Methods for generating stem cells - SBI s tools for stem cell research What

More information

Differentiation = Making specialized cells. Your body needs stem cells. What is a stem cell?

Differentiation = Making specialized cells. Your body needs stem cells. What is a stem cell? Differentiation = Making specialized cells What is a stem cell? What the photo shows A lump of metal and lots of different kinds of screws. Things to think about Lumps of metal that start off the same

More information

Stem cells. Himanshu bhatia, MD Oncology for Scientists (RPN 530)

Stem cells. Himanshu bhatia, MD Oncology for Scientists (RPN 530) Stem cells Himanshu bhatia, MD Himanshu.bhatia@roswellpark.org Oncology for Scientists (RPN 530) 1) Definition of stem cells 2) Adult stem cells 3) Induced pluripotency stem cells 4) Cancer stem cells

More information

STEM CELLS - BASIC CONCEPTS

STEM CELLS - BASIC CONCEPTS STEM CELLS - BASIC CONCEPTS Joel C. Glover Norwegian Center for Stem Cell Research CAST Laboratory of Neural Development and Optical Recording (NDEVOR) Institute of Basic Medical Sciences University of

More information

What are Stem Cells? How can they be used in medicine?

What are Stem Cells? How can they be used in medicine? What are Stem Cells? How can they be used in medicine? What is a stem cell????... What is a stem cell????......a cell with the ability to differentiate into specialized cells and renew to become more stem

More information

Stem Cells and Human Cloning Principle

Stem Cells and Human Cloning Principle Stem Cells and Human Cloning Principle Rationale The research and use of stem cells for exploiting their ability to regenerate into tissues and organs remains a controversial debate and requires a clear

More information

Stem cells state of the ART

Stem cells state of the ART Stem cells state of the ART Pluripotent stem cells in ART how far are we? Peter Kragh SPIREN FERTILITETSKLINIKK & FERTILITETSSEKSJONEN, ST OLAVS HOSPITAL Today: - Stem cells: origin, development - Embryonic

More information

International Stem Cell Registry

International Stem Cell Registry International Stem Cell Registry Importance of Stem Cells Stem cells are model systems for the study of development and disease. Pluripotent stem cells offer new tools for drug design and discovery. Pluripotent

More information

Stem Cell Quick Guide: Stem Cell Basics

Stem Cell Quick Guide: Stem Cell Basics Stem Cell Quick Guide: Stem Cell Basics What is a Stem Cell? Stem cells are the starting point from which the rest of the body grows. The adult human body is made up of hundreds of millions of different

More information

STEM CELL FACTS. The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine.

STEM CELL FACTS. The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine. STEM CELL FACTS The ISSCR is an independent, nonproft organization providing a global forum for stem cell research and regenerative medicine. WHAT ARE STEM CELLS? Stem cells are the foundation cells for

More information

Can replicate itself Can differentiate into many cell types Not all stem cells are pluripotent (nor are they all totipotent)

Can replicate itself Can differentiate into many cell types Not all stem cells are pluripotent (nor are they all totipotent) 1 Stem Cell Notes From National Academies of Science 2 Stem cells Can replicate itself Can differentiate into many cell types Not all stem cells are pluripotent (nor are they all totipotent) Pluripotent:

More information

Stem Cells and Inner Ear Cell Regeneration. Stefan Heller Stanford University School of Medicine

Stem Cells and Inner Ear Cell Regeneration. Stefan Heller Stanford University School of Medicine Stem Cells and Inner Ear Cell Regeneration Stefan Heller Stanford University School of Medicine Embryonic stem cells Induced pluripotent stem cells Somatic stem cells 50 µm Derived from the inner cell

More information

The 2012 Nobel Prize in Physiology or Medicine. John B. Gurdon and Shinya Yamanaka

The 2012 Nobel Prize in Physiology or Medicine. John B. Gurdon and Shinya Yamanaka PRESS RELEASE 2012-10-08 The Nobel Assembly at Karolinska Institutet has today decided to award The 2012 Nobel Prize in Physiology or Medicine jointly to John B. Gurdon and Shinya Yamanaka for the discovery

More information

STEM CELLS. Dr Said Ismail University of Jordan

STEM CELLS. Dr Said Ismail University of Jordan STEM CELLS Dr Said Ismail University of Jordan Introduction: stem cells: (i) renew itself indefinitely (ii) give rise to multiple tissue types A stem cell is not committed to a specific function until

More information

Differentiation = Making specialized cells

Differentiation = Making specialized cells Differentiation = Making specialized cells What is a stem cell? Screws: JM www.logodesignweb.com/stockphoto Differentiation = Making specialized cells What is a stem cell? What the photo shows A lump of

More information

IF YOU HAVE QUESTIONS

IF YOU HAVE QUESTIONS QUESTIONS & ANSWERS MAYO CLINIC CENTER FOR REGENERATIVE MEDICINE BIOTRUST > WHAT IS REGENERATIVE MEDICINE? Regenerative medicine is transforming health care by developing new treatments with the potential

More information

TISSUE ENGINEERING IV. Stem Cells

TISSUE ENGINEERING IV. Stem Cells Harvard-MIT Division of Health Sciences and Technology HST.535: Principles and Practice of Tissue Engineering Instructor: Myron Spector Massachusetts Institute of Technology Harvard Medical School Brigham

More information

Stem cell Therapy in India at Mumbai and Delhi at low Cost

Stem cell Therapy in India at Mumbai and Delhi at low Cost Stem cell Therapy in India at Mumbai and Delhi at low Cost Stem cells are cells that retain the ability to renew themselves through mitotic cell division and can differentiate into a diverse range of specialized

More information

PROPERTIES OF STEM CELLS All stem cells share three basic properties,

PROPERTIES OF STEM CELLS All stem cells share three basic properties, PROPERTIES OF STEM CELLS All stem cells share three basic properties, 1. They can divide and renew themselves by mitotic cell division. Most somatic cells are limited to about 50 divisions due to the loss

More information

Human Embryonic Stem Cell Research Frequently Asked Questions and Fact Sheet

Human Embryonic Stem Cell Research Frequently Asked Questions and Fact Sheet Human Embryonic Stem Cell Research Frequently Asked Questions and Fact Sheet Stem Cell Science Basics What are stem cells? Stem cells are naturally occurring cells that are not yet fully differentiated.

More information

Stem Cells for Dummies

Stem Cells for Dummies Stem Cells for Dummies http://www.newsroom.stemcells.wisc.edu Moira Wood Professor Johnson Immunology 31 October 2011 Dear Reader: One of the most wonderful things about St Olaf is that as a student, you

More information

Stem cell research ACADEMY STATEMENT. progress, hopes and concerns ACADEMY STATEMENT 16 JANUARY 2013

Stem cell research ACADEMY STATEMENT. progress, hopes and concerns ACADEMY STATEMENT 16 JANUARY 2013 ACADEMY STATEMENT 16 JANUARY 2013 ACADEMY STATEMENT Stem cell research progress, hopes and concerns KUNGL. VETENSKAPSAKADEMIEN, BOX 50005, SE-104 05 STOCKHOLM, SWEDEN TEL +46 8 673 95 00, FAX +46 8 15

More information

What are stem cells?

What are stem cells? What are stem s? the experts in stem processing... An introduction to stem s: Q&A What are stem s and what do they do? Stem s are special s with extraordinary powers; they are the building blocks of life.

More information

RESEARCH PAPER BASED ON PATHOLOGY LECTURES AT MEDLINK 2014

RESEARCH PAPER BASED ON PATHOLOGY LECTURES AT MEDLINK 2014 THE DEVELOPMENT OF STEM CELL RESEARCH AND TREATMENTS WITHIN MEDICINE BY JENNA BUXTON Grade awarded: Pass with Merit RESEARCH PAPER BASED ON PATHOLOGY LECTURES AT MEDLINK 2014 ABSTRACT This paper discusses

More information

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures

More information

Direct cardiac reprogramming by defined factors

Direct cardiac reprogramming by defined factors 190 Special Issue: Recent Advances in Stem Cell Biology in Regeneration and Disease Mini Review Direct cardiac reprogramming by defined factors Masaki Ieda 1,2,3) 1) Department of Clinical and Molecular

More information

Chapter 16 Reproductive Technology, Gene Therapy, and Stem Cells (modified)

Chapter 16 Reproductive Technology, Gene Therapy, and Stem Cells (modified) Chapter 16 Reproductive Technology, Gene Therapy, and Stem Cells (modified) Assisted Reproductive Technologies (ART) Artificial insemination (AI) In vitro fertilization (IVF) Gamete intrafallopian transfer

More information

Support structure for genetic material

Support structure for genetic material Support structure for genetic material 1 Making proteins in the RER Making copies of humans 2 Making copies of cells Making copies of genetic material 3 Making copies of genetic material Making copies

More information

Roche Position on Human Stem Cells

Roche Position on Human Stem Cells Roche Position on Human Stem Cells Background Stem cells and treating diseases. Stem cells and their applications offer an enormous potential for the treatment and even the cure of diseases, along with

More information

Stem Cells. Types of stem cells. Tissue specific or adult stem cells. Embryonic stem cells. ES cells come from in vitro fertilization

Stem Cells. Types of stem cells. Tissue specific or adult stem cells. Embryonic stem cells. ES cells come from in vitro fertilization Stem Cells Types of stem cells Characteristics Unspecialized cells Have the potential to form other cell types Self-renewal Can make unlimited copies of themselves Tissue specific or adult stem cells Replenish

More information

Pluripotent stem cell as a source of mesenchymal stem cell

Pluripotent stem cell as a source of mesenchymal stem cell 19 Special Issue: Mesenchymal stem cells Review Article Pluripotent stem cell as a source of mesenchymal stem cell Takumi Era Department of Cell Modulation, Institute of Molecular Embryology and Genetics

More information

Testimony offered on S25, An Act Promoting Stem Cell Research

Testimony offered on S25, An Act Promoting Stem Cell Research based on Testimony offered on S25, An Act Promoting Stem Cell Research Presented to the Joint Committee on Economic Development and Emerging Technology Wednesday, February 16, 2005 Marjorie Clay, PhD Medical

More information

Stem Cells and Hope for Patients

Stem Cells and Hope for Patients Stem Cells and Hope for Patients by Maureen Condic, Ph.D. Most Americans know someone afflicted with an incurable medical condition. The possibility of stem cell cures has given hope to many who face such

More information

Biotechnology. Srivatsan Kidambi, Ph.D.

Biotechnology. Srivatsan Kidambi, Ph.D. Stem Stem Cell Cell Engineering-What, Biology and it Application Why, How?? to Biotechnology Srivatsan Kidambi, Ph.D. Assistant Professor Department of Chemical & Biomolecular Engineering University of

More information

Stem cells possess 2 main characteristics: Sources of pluripotent stem cells: -Long-term self renewal. -The inner cell mass of the blastocyst.

Stem cells possess 2 main characteristics: Sources of pluripotent stem cells: -Long-term self renewal. -The inner cell mass of the blastocyst. Stem cells possess 2 main characteristics: -Long-term self renewal. - They give rise to all types of differentiate cells. Sources of pluripotent stem cells: -The inner cell mass of the blastocyst. - Fetal

More information

Thank you very much Professor Kadowaki for your kind introduction and invitation. It is a great honor to be here today.

Thank you very much Professor Kadowaki for your kind introduction and invitation. It is a great honor to be here today. Prof. Shinya Yamanaka: Thank you very much Professor Kadowaki for your kind introduction and invitation. It is a great honor to be here today. I think many of you know that I am now working on stem cells,

More information

/E' >K <^ K& >/& ^< KE

/E' >K <^ K& >/& ^< KE 10/02/2014 1 10/02/2014 1. Why are stem cells called a reservoir? A. Because they can replace the specialized cells that die/get used up in our body 2. Why are stem cells important in the blood system?

More information

Stem Cell Research: Adult or Somatic Stem Cells

Stem Cell Research: Adult or Somatic Stem Cells Chiang 1 Stem Cell Research: Adult or Somatic Stem Cells Abstract Kelly Chiang Cluster 7 Dr. LeFebvre 07/26/10 Over the past few decades, stem cells have been a controversial topic in the scientific field.

More information

SCENARIO 1: Diabetes WHICH TYPE OF STEM CELL WOULD YOU USE? Teach.Genetics.utah.edu

SCENARIO 1: Diabetes WHICH TYPE OF STEM CELL WOULD YOU USE? Teach.Genetics.utah.edu SCENARIO 1: Diabetes Type 1 diabetes results when cells in the pancreas don t produce insulin. Without insulin, sugar builds up to toxic levels in the bloodstream, damaging the kidneys, eyes, heart, and

More information

Induced Pluripotent Stem Cell Intellectual Property and Commercialization Update

Induced Pluripotent Stem Cell Intellectual Property and Commercialization Update Spring 2009 Induced Pluripotent Stem Cell Intellectual Property and Commercialization Update By David Resnick and Teresa Hopkins Recent developments relating to induced pluripotent stem cell IP are summarized

More information

The Stem Cell Concept

The Stem Cell Concept The Stem Cell Concept What is a Stem Cell? A stem cell is a rela5vely undifferen5ated cell that, when it divides produces at least one daughter cell that retains its undifferen5ated character. Thus, a

More information

56 MaxPlanckForschung 3 09

56 MaxPlanckForschung 3 09 56 MaxPlanckForschung 3 09 One factor is enough for neural stem cells to become pluripotent. They can then be differentiated into smooth muscular cells that are found, for example, in blood and lymph vessels.

More information

Stem Cells-The Future of Medicine?

Stem Cells-The Future of Medicine? Stem Cells-The Future of Medicine? By Dominic Rushton Pass with Merit Research Paper based on Pathology lectures at Medlink 2011 1 This paper will be on the topic of stem cells, and the research and development

More information

) Worksheets 2-2 How a Cell Operates ) Cell Activities PowerPoint ) Crossword Cell Activities Review

) Worksheets 2-2 How a Cell Operates ) Cell Activities PowerPoint ) Crossword Cell Activities Review Human Anatomy Unit 2 Chapter 3 and 4 Cells and Tissues Name P. Date Turn your stamp sheet by the day of test or one day after for chance at full credit. After that, max points = half credit. GET ANY INCOMPLETE

More information

PART I. SECTION 1. The legislature finds that an estimated. 128,000,000 Americans suffer from the crippling economic and

PART I. SECTION 1. The legislature finds that an estimated. 128,000,000 Americans suffer from the crippling economic and HOUSE OF REPRESENTATIVES TWENTY-FOURTH LEGISLATURE, 2007 STATE OF HAWAII A BILL FOR AN ACT RELATING TO MEDICAL RESEARCH. BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF HAWAII: PART I SECTION 1. The legislature

More information

Should Stem Cells Be Used To Treat Human Diseases?

Should Stem Cells Be Used To Treat Human Diseases? SAMPLE ESSAY C Should Stem Cells Be Used To Treat Human Diseases? Stem cells can be defined as undifferentiated cells that are generated during the development of the embryo. There are two functions ascribed

More information

It s not something you want to think about, but it s something you want to prepare for.

It s not something you want to think about, but it s something you want to prepare for. It s not something you want to think about, but it s something you want to prepare for. StemCyte cord blood banking offers your family a new lifesaving treatment alternative Why Bank Take the once-in-alifetime

More information

Florida State University Libraries

Florida State University Libraries Florida State University Libraries Undergraduate Research Honors Ethical Issues and Life Choices (PHI2630) 2013 The Moral Issues of Embryonic Stem Cell Research, and Their Potential Solution Amber Denton

More information

Stem cells and motor neurone disease

Stem cells and motor neurone disease Stem cells and motor neurone disease F Stem cell research has fuelled hope of a treatment for a variety of conditions. This information sheet explains what these cells are and includes details of the current

More information

Bio40C Schedule. Review: Structure and Function of DNA. Genetics and Inherited diseases. DNA Function

Bio40C Schedule. Review: Structure and Function of DNA. Genetics and Inherited diseases. DNA Function Bio40C Schedule Mar 16/18 Fri Mar 26 4-6 pm Lecture Genetics Molecular and genetic medicine Review EXAM 3 Ch 18, 28 and 29 Lab Quiz 4: Endocrine & Reprod systems How is the embryo protected from maternal

More information

Current State of Stem Cell Treatments for Cerebral Palsy: A Guide for Patients, Families, and Service Providers

Current State of Stem Cell Treatments for Cerebral Palsy: A Guide for Patients, Families, and Service Providers Current State of Stem Cell Treatments for Cerebral Palsy: A Guide for Patients, Families, and Service Providers Stephanie Beldick Michael G. Fehlings Krembil Research Institute, University Health Network

More information

Introducing stem cells

Introducing stem cells Introducing stem cells 1 Dear speaker This presentation is intended as a flexible tool for scientists, science communicators and educators. Not all the slides will be useful for any one occasion. Choose

More information

5 Frequently Asked Questions About Adult Stem Cell Research

5 Frequently Asked Questions About Adult Stem Cell Research 5 Frequently Asked Questions About Adult Stem Cell Research Stem cells are often referred to in the sociopolitical realm with some level of controversy and beyond that, some level of confusion. Many researchers

More information

Guidance For Research Involving Human Embryonic Stem Cells, Germ Cells, And Cells Obtained From Cord Blood

Guidance For Research Involving Human Embryonic Stem Cells, Germ Cells, And Cells Obtained From Cord Blood Guidance For Research Involving Human Embryonic Stem Cells, Germ Cells, And Cells Obtained From Cord Blood Supreme Council of Health Department of Research Guidance Regarding Research Involving Human Embryonic

More information

Briefing on the second reading of the Human Fertilisation and Embryology Bill, Monday 19 November 2007.

Briefing on the second reading of the Human Fertilisation and Embryology Bill, Monday 19 November 2007. Briefing on the second reading of the Human Fertilisation and Embryology Bill, Monday 19 November 2007. Prepared by the Medical Research Council, Royal Society and Wellcome Trust The Medical Research Council,

More information

The Types of stem cells: Totipotent Pluripotent Multipotent

The Types of stem cells: Totipotent Pluripotent Multipotent Stem Cells is the main material for building and regeneration of the body Stem cells are not differentiated and can transform to any cell of organism Stem cells are capable of indefinite renewal through

More information

MEDICINE Scientific American

MEDICINE Scientific American MEDICINE Reprogramming cells from your own body could give them the therapeutic power of embryonic stem cells, without the political controversy BY KONRAD HOCH EDLINGER BRYAN CHRISTIE DESIGN KEY CONCEPTS

More information

STEM CELL FELLOWSHIP

STEM CELL FELLOWSHIP Module I: The Basic Principles of Stem Cells 1. Basics of Stem Cells a. Understanding the development of embryonic stem cells i. Embryonic stem cells ii. Embryonic germ cells iii. Differentiated stem cell

More information

The ethics of stem cell research and treatment

The ethics of stem cell research and treatment The ethics of stem cell research and treatment Bernard Lo, M.D. March 12, 2009 1 hesc: ethical controversies Moral status of embryo? Clearly a potential person Some believe a person with rights Is hesc

More information

The use of autologous cell therapy for treatment of cardiac disease

The use of autologous cell therapy for treatment of cardiac disease The use of autologous cell therapy for treatment of cardiac disease IET Present Around The World Competition London, 9 th Nov. 2011 Representing EMEA Theodora Chrysostomou Overview Autologous stem cell

More information

Read the following questions below before reading the article. Then, read the article in order to answer the questions.

Read the following questions below before reading the article. Then, read the article in order to answer the questions. Reading 1: Animals Cloned (25 minutes / 25 points) Read the following questions below before reading the article. Then, read the article in order to answer the questions. 1. Where would you find this reading?

More information

Biochemistry Major Talk 2014-15. Welcome!!!!!!!!!!!!!!

Biochemistry Major Talk 2014-15. Welcome!!!!!!!!!!!!!! Biochemistry Major Talk 2014-15 August 14, 2015 Department of Biochemistry The University of Hong Kong Welcome!!!!!!!!!!!!!! Introduction to Biochemistry A four-minute video: http://www.youtube.com/watch?v=tpbamzq_pue&l

More information

Using Stem Cells to Study the Developmental Biology of Disease: Case Studies in ALS

Using Stem Cells to Study the Developmental Biology of Disease: Case Studies in ALS Using Stem Cells to Study the Developmental Biology of Disease: Case Studies in ALS Kevin Eggan Stowers Medical Institute and Harvard Stem Cell Institute Department of Stem Cell and Regenerative Biology

More information

Update on MS research

Update on MS research Update on MS research Anna Williams Scottish Senior Research Fellow and Honorary Consultant Neurologist Plan Where do we do MS research in Edinburgh? What is missing in MS therapy? 2 ways to improve brain

More information

Stem cells and motor neurone disease

Stem cells and motor neurone disease Stem cells and motor neurone disease F Stem cell research has fuelled hope of a treatment for a variety of conditions. This information sheet explains what these cells are and how they may be used to create

More information

Reprogramming, Screening and Validation of ipscs and Terminally Differentiated Cells using the qbiomarker PCR Array System

Reprogramming, Screening and Validation of ipscs and Terminally Differentiated Cells using the qbiomarker PCR Array System Reprogramming, Screening and Validation of ipscs and Terminally Differentiated Cells using the qbiomarker PCR Array System Outline of Webinar What are induced pluripotent Stem Cells (ips Cells or ipscs)?

More information

Introduction. Materials

Introduction. Materials Lesson 2 Techniques for Obtaining Stem Cells Objectives Students will be able to: Describe scientific techniques (IVF, therapeutic cloning, using cord blood and bone marrow, inducing pluripotent stem cells)

More information

Patient Handbook on Stem Cell Therapies

Patient Handbook on Stem Cell Therapies Patient Handbook on Stem Cell Therapies Appendix I of the Guidelines for the Clinical Translation of Stem Cells www.isscr.org 2008, International Society for Stem Cell Research 2 Introduction We have all

More information

15 Stem Cell Research

15 Stem Cell Research 15 Stem Cell Research t a l k it o v e r 1 c l a s s se s s i o n Overview Students read about current scientific research on and the social controversy over embryonic stem cells. On a KWL literacy strategy

More information

tem ells /background /information Stem cell research Copyright 2007 MRC Centre for Regenerative Medicine, Institute for Stem Cell Research

tem ells /background /information Stem cell research Copyright 2007 MRC Centre for Regenerative Medicine, Institute for Stem Cell Research tem ells /background /information Stem cell research Copyright 2007 MRC Centre for Regenerative Medicine, Institute for Stem Cell Research /02 /information Table of contents Page 01. What are stem cells?

More information

European Scientific, Ethical, and Legal Issues on Human Stem Cell Research and Regenerative Medicine

European Scientific, Ethical, and Legal Issues on Human Stem Cell Research and Regenerative Medicine European Scientific, Ethical, and Legal Issues on Human Stem Cell Research and Regenerative Medicine OUTI HOVATTA, MIODRAG STOJKOVIC, MARIA NOGUEIRA, ISABEL VARELA-NIETO INTRODUCTION In 2002, the European

More information

An Introduction to Stem Cell Biology. Michael L. Shelanski, MD,PhD Professor of Pathology and Cell Biology Columbia University

An Introduction to Stem Cell Biology. Michael L. Shelanski, MD,PhD Professor of Pathology and Cell Biology Columbia University An Introduction to Stem Cell Biology Michael L. Shelanski, MD,PhD Professor of Pathology and Cell Biology Columbia University Figures adapted from ISSCR. Presentations of Drs. Martin Pera (Monash University),

More information

TISSUE ENGINEERING: STEM CELLS

TISSUE ENGINEERING: STEM CELLS Massachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.79J/3.96J/BE.441/HST522J TISSUE ENGINEERING: STEM CELLS I.V. Yannas, Ph.D. and M.

More information

How do scientists obtain stem cells?

How do scientists obtain stem cells? Alternatives to Human Embryonic Stem Cells H Keva Green ow can we advance stem cell research without destroying human life in the process? This question confronts scientists, lawmakers and many others

More information

Stem Cells: Scientific Progress and Future Research Directions

Stem Cells: Scientific Progress and Future Research Directions 2001 Terese Winslow Stem Cells: Scientific Progress and Future Research Directions STEM CELLS: SCIENTIFIC PROGRESS AND FUTURE RESEARCH DIRECTIONS June 2001 This page intentionally left blank TABLE OF CONTENTS

More information

Please visit this site for the current GESCR procedures info: http://www.research.ucsf.edu/chr/stemcell/scprocedures.asp

Please visit this site for the current GESCR procedures info: http://www.research.ucsf.edu/chr/stemcell/scprocedures.asp GESCR PROCEDURES: REVIEW PROCESS AND LEVELS OF REVIEW Office of Origin: Human Research Protection Program Effective Date: January 2012 I. Introduction The Human Gamete, Embryo and Stem Cell Research (GESCR)

More information

Progress in Stem-Cell Research and New Medical Care *1

Progress in Stem-Cell Research and New Medical Care *1 Conferences and Lectures JMARI Symposium on Advanced Medicine and Gene Information Progress in Stem-Cell Research and New Medical Care *1 JMAJ 56(6): 417 433, 2013 Hiromitsu NAKAUCHI* 2 Abstract Stem cells

More information

Patient Handbook on Stem Cell Therapies

Patient Handbook on Stem Cell Therapies Patient Handbook on Stem Cell Therapies WWW.ISSCR.ORG WWW.CLOSERLOOKATSTEMCELLS.ORG Patient Handbook on Stem Cell Therapies Introduction We have all heard about the extraordinary promise that stem cell

More information

ADVANCE DIRECTIVE VOLUME 18 FALL 2008 PAGES Reprogramming the Future of Stem Cell Patents. Jana E. Harris, Ph.D. *

ADVANCE DIRECTIVE VOLUME 18 FALL 2008 PAGES Reprogramming the Future of Stem Cell Patents. Jana E. Harris, Ph.D. * ANNALS OF HEALTH LAW ADVANCE DIRECTIVE VOLUME 18 FALL 2008 PAGES 10-15 Reprogramming the Future of Stem Cell Patents Jana E. Harris, Ph.D. * Stem cells have the potential to be extremely powerful tools

More information

Precision gene therapy

Precision gene therapy Huntington s disease research news. In plain language. Written by scientists. For the global HD community. Gene therapy meets stem cells in liver disease success Scientists combine gene therapy and stem

More information

Teacher Guide: Stem Cells in the Spotlight Web Quest

Teacher Guide: Stem Cells in the Spotlight Web Quest ACTIVITY OVERVIEW Abstract: Students navigate the Stem Cells in the Spotlight module to complete a web quest to learn about stem cells. Module: Stem Cells in the Spotlight Prior Knowledge Needed: None

More information

Alternatives to cloning

Alternatives to cloning Nr. 140 August 2000 Alternatives to cloning New research into stem cells poses a challenge to the needs of therapeutic cloning The British government backs research in stem cells on human fetuses > Research

More information

Cell Interactions and Stem Cells

Cell Interactions and Stem Cells Cell Interactions and Stem Cells Recognize the importance of cell interactions, cell signaling and cell-cell interactions, for coordination of functions in a multi-cellular organism. Learn the three stages

More information

Human cord blood reprogrammed into embryonic-like stem cells

Human cord blood reprogrammed into embryonic-like stem cells STATE OF THE ART 3B-PL2 ISBT Science Series (2011) 6, 107 111 ª 2011 The Author(s). ISBT Science Series ª 2011 International Society of Blood Transfusion Human cord blood reprogrammed into embryonic-like

More information

Biology and Society. Unit Five: Human Reproduction. Topic Six: Stem Cell Research

Biology and Society. Unit Five: Human Reproduction. Topic Six: Stem Cell Research Biology and Society Unit Five: Human Reproduction Topic Six: Stem Cell Research The issue of stem cell research burst on the scientific scene in November of 1998 when researchers first reported the isolation

More information

Stem Cell Information

Stem Cell Information Stem Cell Information The official National Institutes of Health resource for stem cell research Stem Cell Basics Stem cells have the remarkable potential to develop into many different cell types in the

More information

Human stem cell research: a novel technology that will benefit patients Information and Position Paper

Human stem cell research: a novel technology that will benefit patients Information and Position Paper October 2003 Human stem cell research: a novel technology that will benefit patients Information and Position Paper EuropaBio, the European Association for Bio-industries, has 35 corporate members operating

More information

14 Stem Cell Differentiation investigation 1 c l a s s se s s i o n

14 Stem Cell Differentiation investigation 1 c l a s s se s s i o n 14 Stem Cell Differentiation investigation 1 c l a s s se s s i o n Overview To investigate how embryonic stem cells become specialized cells, students draw from a set of colored chips that represent specific

More information

Ethics and the Clinical Translation of Stem Cell Research

Ethics and the Clinical Translation of Stem Cell Research Ethics and the Clinical Translation of Stem Cell Research Jeremy Sugarman, MD, MPH, MA Harvey M. Meyerhoff Professor of Bioethics & Medicine Department of Medicine Berman Institute of Bioethics Johns Hopkins

More information

POSITION STATEMENT REGARDING THE USE OF EMBRYONIC AND ADULT HUMAN STEM CELLS IN BIOMEDICAL RESEARCH October 2004

POSITION STATEMENT REGARDING THE USE OF EMBRYONIC AND ADULT HUMAN STEM CELLS IN BIOMEDICAL RESEARCH October 2004 POSITION STATEMENT REGARDING THE USE OF EMBRYONIC AND ADULT HUMAN STEM CELLS IN BIOMEDICAL RESEARCH October 2004 Preamble The American Academy of Neurology (AAN) and the American Neurological Association

More information

Instructions: Please complete the application and send a copy to:

Instructions: Please complete the application and send a copy to: Instructions: Please complete the application and send a copy to: som-resadmin@case.edu When completing the SCRO form as part of an IRB/IACUC submission you will need to upload a copy of this SCRO form

More information

Amended Pharmaceutical Affairs Law and Regenerative Medicine 19 th June 2014 International Regulatory Science Symposium

Amended Pharmaceutical Affairs Law and Regenerative Medicine 19 th June 2014 International Regulatory Science Symposium Amended Pharmaceutical Affairs Law and Regenerative Medicine 19 th June 2014 International Regulatory Science Symposium Shinji MIYAKE, Ph.D. Professor, Keio Center for Clinical Research, School of Medicine,

More information

THE PROMISE OF STEM CELLS

THE PROMISE OF STEM CELLS June 2002 THE PROMISE OF STEM CELLS FROM RESEARCH TO MEDICAL THERAPIES As scientists search for treatments for disease, they often benefit from breakthroughs in understanding the basic biology of the cell.

More information