Annual Publication Report

Transcription

1 Annual Publication Report 2009 TABLE OF CONTENTS 2 GRONINGEN INSTITUTE FOR KIDNEY DISEASES GIKD 9 CARDIOVASCULAR CENTER CVC 19 GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD GRIAC 24 CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES CLDS 31 INSTITUTE FOR TRANSPLANTATION, IMMUNITY AND INFLAMMATION TRIO 46 NORTHERN NETHERLANDS ONCOLOGY CENTER NNOC 63 INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY BDDD 67 CENTER FOR SYNTHESIS AND ANALYSIS S&A

2 GRONINGEN INSTITUTE FOR KIDNEY DISEASES - GIKD Dissertations Boersma, C. Health Economics of cardiovascular & renal disease prevention. (2009) Damman, K. Cardiorenal interaction in heart failure. (2009) Hillege, H. L., Veldhuisen, D. J., Navis, G. J., and Voors, A. A. de Vries, R. Lipid transfer proteins: consequences for cellular cholesterol efflux and cardiovascular risk in diabetes mellitus. (2009) Wolfenbuttel, B. H. R., Dullaart, R. P. F., and van Tol, A. Koudstaal, L. G. The impact of cerebral injury in donation and transplantation : a central role of the intestine. (2009) Ploeg, R. J., van Goor, H., and Leuvenink, H. G. D. Loef, B. G. Acute kidney injury after cardiac surgery : impact on long-term outcome and target for intervention. (2009) Ebels, T., Navis, G. J., Epema, A. H., and Stegeman, C. A. Meijering, B. D. M. Ultrasound and microbubble targeted delivery : exploring the mechanism and its therapeutic potential. (2009) Henning, R. H., van Gilst, W. H., and Deelman, L. E. Melenhorst, W. B. W. H. The biology of ADAMs in renal disease. (2009) van Goor, H. and Visser, L. Rook, M. Living kidney donor safety : insights & outcome. (2009) Navis, G. J., Ploeg, R. J., van Goor, H., van Son, W. J., and Homan van der Heide, J. J. Sanders, J. S. F. Disease-activity in ANCA-associated vasculitis. (2009) Kallenberg, C. G. M. and Stegeman, C. A. Ulu, N. Vascular function in chronic end-organ damage : pharmacological characterization of vasomotor function in systemic vasculature. (2009) Henning, R. H., van Gilst, W. H., Buikema, H., and Schoemaker, R. G. van der Toorn, M. Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in. (2009) Kauffman, H. F., Gans, R. O. B., Koëter, G. H., Slebos, D. J., and Bakker, S. J. L. van Ree, R. M. Chronic low-grade inflammation in renal transplantation. (2009) Gans, R. O. B., Bakker, S. J. L., van Son, W. J., and Homan van der Heide, J. J. vom Hagen, F. M. Experimental models of retinal angiogenesis : the effect of angiopoietin-2 and TNFa modulation. (2009) Molema, G., Hammes, H.-P., and Gans, R. O. B. Journal articles Alkhalaf, A., Kleefstra, N., Groenier, K. H., Bakker, S. J. L., Navis, G. J., Bilo, H. J. G. Thiamine in diabetic nephropathy: a novel treatment modality? Diabetologia 52(6): , Bakker, S. J. L., Gansevoort, R. T., de Zeeuw, D. Albuminuria: What can we expect from the determination of nonimmunoreactive albumin? Current Hypertension Reports 11(2): , Bakker, W. W., Henning, R. H., van Son, W. J., van Pampus, M. G., Aarnoudse, J. G., Niezen-Koning, K. E., Borghuis, T., Jongman, R. M., van Goor, H., Poelstra, K., Navis, G., Faas, M. M. Vascular Contraction and Preeclampsia Downregulation of the Angiotensin Receptor 1 by Hemopexin In Vitro. Hypertension 53(6): 959-U127, Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): , Boersema, M., Rienstra, H., van den Heuvel, M., van Goor, H., van Luyn, M. J. A., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Contribution to Transplant Vasculopathy in Chronic Renal Transplant Dysfunction. Transplantation 88(12): , Bos, E. M., Leuvenink, H. G. D., Snijder, P. M., Kloosterhuis, N. J., Hillebrands, J. L., Leemans, J. C., Florquin, S., van Goor, H. Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury. Journal of the American Society of Nephrology 20(9): , Broekema, M., Harmsen, M. C., Koerts, J. A., van Kooten, T. G., Uges, D. R. A., Petersen, A. H., van Luyn, M. J. A., Navis, G., Popa, E. R. Ciclosporin Does Not Influence Bone Marrow-Derived Cell Differentiation to Myofibroblasts Early after Renal Ischemia/Reperfusion. American Journal of Nephrology 30(1): 73-83, Celie, J. W. A. M., Beelen, R. H. J., van den Born, J. Heparan sulfate proteoglycans in extravasation: assisting leukocyte guidance. Frontiers in Bioscience 14: , 2

3 Chen, C., Liang, W., Jia, J. Y., van Goor, H., Singhal, P. C., Ding, G. H. Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3- K/Akt and p38mapk Signaling Pathways. Nephron Experimental Nephrology 113(1): E26-E34, Corpeleijn, E., Bakker, S. J. L., Stolk, R. P. Obesity and impaired renal function: potential for lifestyle intervention? European Journal of Epidemiology 24(6): , Damman, K., Jaarsma, T., Voors, A. A., Navis, G., Hillege, H. L., van Veldhuisen, D. J. Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH). European Journal of Heart Failure 11(9): , Damman, K., van Deursen, V. M., Navis, G., Voors, A. A., van Veldhuisen, D. J., Hillege, H. L. Increased Central Venous Pressure Is Associated With Impaired Renal Function and Mortality in a Broad Spectrum of Patients With Cardiovascular Disease. Journal of the American College of Cardiology 53(7): , Dasselaar, J. J., Slart, R. H. J. A., Knip, M., Pruim, J., Tio, R. A., McIntyre, C. W., de Jong, P. E., Franssen, C. F. M. Haemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrology Dialysis Transplantation 24(2): , de Borst, M. H., Prakash, J., Sandovici, M., Klok, P. A., Hamming, I., Kok, R. J., Navis, G., van Goor, H. c-jun NH2-Terminal Kinase Is Crucially Involved in Renal Tubulo-Interstitial Inflammation. Journal of Pharmacology and Experimental Therapeutics 331(3): , de Jong, P. E., Gansevoort, R. T. Focus on Microalbuminuria to Improve Cardiac and Renal Protection. Nephron Clinical Practice 111(3): C204-C210, de Leeuw, K., Smit, A. J., de Groot, E., van Roon, A. M., Kallenberg, C. G., Bijl, M. Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus. Atherosclerosis 206(2): , de Zeeuw, D., Lambers-Heerspink, H. Drug Dosing for Renoprotection: Maybe It's Time for a Drug Efficacy-Safety Score? Journal of the American Society of Nephrology 20(4): , Dobre, D., Nimade, S., de Zeeuw, D. Albuminuria in heart failure: what do we really know? Current Opinion in Cardiology 24(2): , Dobre, D., Heerspink, H. J. L., de Zeeuw, D. Reducing cardiovascular risk: protecting the kidney. European Heart Journal Supplements 11(F): F39-F46, Doorenbos, C. R. C., van den Born, J., Navis, G., de Borst, M. H. Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism. Nature Reviews Nephrology 5(12): , Dullaart, R. P. F. Comment on high HDL-cholesterol in women with rheumatoid arthritis on low-dose glucocorticoid therapy. European Journal of Clinical Investigation 39(6): 533, Dullaart, R. P. F., de Vries, R., Sluiter, W. J., Voorbij, H. A. M. High plasma C-reactive protein (CRP) is related to low paraoxonase-i (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus. Clinical Endocrinology 70(2): , Dullaart, R. P. F., Plomgaard, P., de Vries, R., Dahlback, B., Nielsen, L. B. Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness. Clinica Chimica Acta 406(1-2): , Dullaart, R. P. F., de Vries, R., Voorbij, H. A. M., Sluiter, W. J., van Tol, A. Serum paraoxonase-i activity is unaffected by short-term administration of simvastatin, bezafibrate, and their combination in type 2 diabetes mellitus. European Journal of Clinical Investigation 39(3): , Fabbrini, P., Schilte, M. N., Zareie, M., ter Wee, P. M., Keuning, E. D., Beelen, R. H. J., van den Born, J. Celecoxib treatment reduces peritoneal fibrosis and angiogenesis and prevents ultrafiltration failure in experimental peritoneal dialysis. Nephrology Dialysis Transplantation 24(12): , Gansevoort, R. T., Ritz, E. Hermann Senator and albuminuria- 025EFforgotten pioneering work in the 19th century. Nephrology Dialysis Transplantation 24(3): , Gansevoort, R. T., de Jong, P. E. The Case for Using Albuminuria in Staging Chronic Kidney Disease. Journal of the American Society of Nephrology 20(3): , Gerrits, E. G., Smit, A. J., Bilo, H. J. G. AGEs, autofluorescence and renal function. Nephrology Dialysis Transplantation 24(3): , Halbesma, N., Bakker, S. J. L., Jansen, D. F., Stolk, R. P., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function. Journal of the American Society of Nephrology 20(8): , Heerspink, H. J. L., Nauta, F. L., van der Zee, C. P., Brinkman, J. W., Gansevoort, R. T., de Zeeuw, D., Bakker, S. J. L. Alkalinization of urine samples preserves albumin concentrations during prolonged frozen storage in patients with diabetes mellitus. Diabetic Medicine 26(5): , Heerspink, H. J. L., Perkovic, V., de Zeeuw, D. Renal and cardioprotective effects of direct renin inhibition: a systematic literature review. Journal of Hypertension 27(12): , 3

4 Heerspink, H. J. L., Agarwal, R., Coyne, D. W., Parving, H. H., Ritz, E., Remuzzi, G., Audhya, P., Amdahl, M. J., Andress, D. L., Zeeuw, D. The Selective Vitamin D Receptor Activator for Albuminuria Lowering (VITAL) Study: Study Design and Baseline Characteristics. American Journal of Nephrology 30(3): , Heerspink, H. L., Ninomiya, T., Zoungas, S., de Zeeuw, D., Grobbee, D. E., Jardine, M. J., Gallagher, M., Roberts, M. A., Cass, A., Neal, B., Perkovic, V. Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials. Lancet 373(9668): , Herman, W. H., Dungan, K. M., Wolffenbuttel, B. H. R., Buse, J. B., Fahrbach, J. L., Jiang, H. H., Martin, S. Racial and Ethnic Differences in Mean Plasma Glucose, Hemoglobin A(1c), and 1,5-Anhydroglucitol in Over 2000 Patients with Type 2 Diabetes. Journal of Clinical Endocrinology & Metabolism 94(5): , Hettema, M. E., Zhang, D., Stienstra, Y., Smit, A. J., Bootsma, H., Kallenberg, C. G. M. No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. Clinical Rheumatology 28(7): , Jochemsen, B. M., Mulder, D. J., van Doormaal, J. J., Mulder, G., Volmer, M., Graaff, R., Smit, A. J. Relation between food and drinking habits, and skin autofluorescence and intima media thickness in subjects at high cardiovascular risk. Journal of Food and Nutrition Research 48(1): 51-58, Kamilic, J., Lely, A. T., van Goor, H., Buikema, H., Tent, H., Navis, G. J., Korstanje, R. Differential ACE expression among tissues in allele-specific Wistar rat lines. Mammalian Genome 20(3): , Kappelle, P. J. W. H., Zwang, L., Huisman, M. V., Banga, J. D., Sluiter, W. J., linga-thie, G. M., Dullaart, R. P. F. Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein. Expert Opinion on Therapeutic Targets 13(7): , Koetsier, M., Lutgers, H. L., Smit, A. J., Links, T. P., de Vries, R., Gans, R. O. B., Rakhorst, G., Graaff, R. Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient. Optics Express 17(2): , Koudstaal, L. G., Ottens, P. J., Uges, D. R. A., Ploeg, R. J., van Goor, H., Leuvenink, H. G. D. Increased Intestinal Permeability in Deceased Brain Dead Rats. Transplantation 88(3): , Kramer, A. B., van Timmeren, M. M., Schuurs, T. A., Vaidya, V. S., Bonventre, J. V., van Goor, H., Navis, G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. American Journal of Physiology-Renal Physiology 296(5): F1136-F1145, Krikken, J. A., Waanders, F., linga-thie, G. M., Dikkeschei, L. D., Vogt, L., Navis, G. J., Dullaart, R. P. F. Antiproteinuric therapy decreases LDL-cholesterol as well as HDL-cholesterol in nondiabetic proteinuric patients: relationships with cholesteryl ester transfer protein mass and adiponectin. Expert Opinion on Therapeutic Targets 13(5): , Krikken, J. A., Laverman, G. D., Navis, G. Benefits of dietary sodium restriction in the management of chronic kidney disease. Current Opinion in Nephrology and Hypertension 18(6): , Krikken, J. A., Bakker, S. J. L., Navis, G. J. Role of renal haemodynamics in the renal risks of overweight. Nephrology Dialysis Transplantation 24(6): , Kurth, T., de Jong, P. E., Cook, N. R., Buring, J. E., Ridker, P. M. Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study. British Medical Journal 339 AR b2392 DI /bmj.b2392 Lambers Heerspink, H. J., Dobre, D., de Zeeuw, D. Does the European clinical trials directive really improve clinical trial approval time? Pharmaceutisch Weekblad 144(38): , Laverman, G. D., Bakker, S. J. L., Navis, G. J. Optimal dosing of reninangiotensin-aldosterone system blockers for renal protection: a solved issue? Diabetologia 52(6): , linga-thie, G. M., van Tol, A., Dullaart, R. P. F. Plasma pre beta-hdl formation is decreased by atorvastatin treatment in type 2 diabetes mellitus: Role of phospholipid transfer protein. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1791(8): , Linssen, G. C. M., Damman, K., Hillege, H. L., Navis, G., van Veldhuisen, D. J., Voors, A. A. Urinary N-Terminal Prohormone Brain Natriuretic Peptide Excretion in Patients With Chronic Heart Failure. Circulation 120(1): 35-41, Loef, B. G., Epema, A. H., Navis, G., Ebels, T., Stegeman, C. A. Postoperative renal dysfunction and preoperative left ventricular dysfunction predispose patients to increased long-term mortality after coronary artery bypass graft surgery. British Journal of Anaesthesia 102(6): , Logtenberg, S. J., Kleefstra, N., Houweling, S. T., Groenier, K. H., Gans, R. O., van Ballegooie, E., Bilo, H. J. Improved Glycemic Control With Intraperitoneal Versus Subcutaneous Insulin in Type 1 Diabetes A randomized controlled trial. Diabetes Care 32(8): , 4

5 Logtenberg, S. J. J., Kleefstra, N., Groenier, K. H., Gans, R. O. B., Bilo, H. J. G. Use of Short-Term Real-Time Continuous Glucose Monitoring in Type 1 Diabetes Patients on Continuous Intraperitoneal Insulin Infusion: A Feasibility Study. Diabetes Technology & Therapeutics 11(5): , Lutgers, H. L., Gerrits, E. G., Sluiter, W. J., Ubink-Veltmaat, L. J., Landman, G. W. D., Links, T. P., Gans, R. O. B., Smit, A. J., Bilo, H. J. G. Life Expectancy in a Large Cohort of Type 2 Diabetes Patients Treated in Primary Care (ZODIAC-10). PLoS ONE 4(8 AR e6817 DI /journal.pone ) Lutgers, H. L., Gerrits, E. G., Graaff, R., Links, T. P., Sluiter, W. J., Gans, R. O., Bilo, H. J., Smit, A. J. Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus. Diabetologia 52(5): , Mahmoodi, B. K., Gansevoort, R. T., Kluin-Nelemans, H. C. Antiphospholipid Syndrome, Microalbuminuria, and Risk of Venous Thromboembolism Reply. JAMA - Journal of the American Medical Association 302(9): , Mahmoodi, B. K., Gansevoort, R. T., Veeger, N. J. G. M., Matthews, A. G., Navis, G., Hillege, H. L., van der Meer, J. Microalbuminuria and Risk of Venous Thromboembolism. JAMA - Journal of the American Medical Association 301(17): , Martens, D. H. J., Rake, J. P., Navis, G., Fidler, V., van Dael, C. M. L., Smit, G. P. A. Renal Function in Glycogen Storage Disease Type I, Natural Course, and Renopreservative Effects of ACE Inhibition. Clinical Journal of the American Society of Nephrology 4(11): , Martens, H. A., Zuurman, M. W., de Lange, A. H. M., Nolte, I. M., van der Steege, G., Navis, G. J., Kallenberg, C. G. M., Seelen, M. A., Bijl, M. Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity. Annals of the Rheumatic Diseases 68(5): , Meerwaldt, R., Zeebregts, C. J., Navis, G., Hillebrands, J. L., Lefrandt, J. D., Smit, A. J. Accumulation of Advanced Glycation End Products and Chronic Complications in ESRD Treated by Dialysis. American Journal of Kidney Diseases 53(1): , Meijer, E., Bakker, S. J. L., de Jong, P. E., van der Heide, J. J. H., van Son, W. J., Struck, J., Lems, S. P. M., Gansevoort, R. T. Copeptin, a Surrogate Marker of Vasopressin, Is Associated With Accelerated Renal Function Decline in Renal Transplant Recipients. Transplantation 88(4): , Meijer, E., de Jong, P. E., van der Jagt, E. J., Peters, D. J., Breuning, M. H., Gansevoort, R. T. Hereditary cystinuria: New insights and possible treatments. Nederlands Tijdschrift voor Geneeskunde 153(20): , Meijering, B. D. M., van der Wouden, E. A., Pelgrom, V., Henning, R. H., Sharma, K., Deelman, L. E. TGF-beta Inhibits Ang II-Induced MAPK p44/42 Signaling in Vascular Smooth Muscle Cells by Ang II Type 1 Receptor Downregulation. Journal of Vascular Research 46(5): , Meijering, B. D. M., Juffermans, L. J. M., van Wamel, A., Henning, R. H., Zuhorn, I. S., Emmer, M., Versteilen, A. M. G., Paulus, W. J., van Gilst, W. H., Kooiman, K., de Jong, N., Musters, R. J. P., Deelman, L. E., Kamp, O. Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation. Circulation Research 104(5): 679-U226, Melenhorst, W. B., Visser, L., Timmer, A., van den Heuvel, M. C., Stegeman, C. A., van Goor, H. ADAM17 upregulation in human renal disease: a role in modulating TGF-alpha availability? American Journal of Physiology-Renal Physiology 297(3): F781- F790, Muntinghe, F. L. H., Verduijn, M., Zuurman, M. W., Grootendorst, D. C., Carrero, J. J., Qureshi, A. R., Luttropp, K., Nordfors, L., Lindholm, B., Brandenburg, V., Schalling, M., Stenvinkel, P., Boeschoten, E. W., Krediet, R. T., Navis, G., Dekker, F. W. CCR5 Deletion Protects Against Inflammation-Associated Mortality in Dialysis Patients. Journal of the American Society of Nephrology 20(7): , Muntinghe, F. L. H., Gross, S., Bakker, S. J. L., Landman, G. W. D., van der Harst, P., Bilo, H. J. G., Navis, G., Zuurman, M. W. CCR5 Delta 32 genotype is associated with outcome in type 2 diabetes mellitus. Diabetes Research and Clinical Practice 86(2): , Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., Heath, S. C., Eyheramendy, S., Papadakis, K., Voight, B. F., Scott, L. J., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, J. C., Khaw, K. T., Nilsson, P., van der Harst, P., Polidoro, S., Grobbee, D. E., Onland-Moret, N. C., Bots, M. L., Wain, L. V., Elliott, K. S., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, P. R., Hadley, D., McArdle, W. L., Brown, M., Dominiczak, A., Newhouse, S. J., Samani, N. J., Webster, J., Zeggini, E., Beckmann, J. S., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, D. M., Yuan, X., Groop, L., Orho-Melander, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Sandhu, M. S., Luben, R. N., Crawford, G. J., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, L. L., Collins, F. S., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Valle, T. T., Willer, C. J., Bergman, R. N., Morken, M. A., Doring, A., Gieger, C., Illig, T., Meitinger, T., Org, E., Pfeufer, A., Wichmann, H. E., Kathiresan, S., Marrugat, J., O'Donnell, C. J., Schwartz, S. M., Siscovick, D. S., Subirana, I., Freimer, N. B., Hartikainen, A. L., McCarthy, M. I., O'Reilly, P. F., Peltonen, L., Pouta, A., de Jong, P. E., Snieder, H., van Gilst, W. H., Clarke, R., Goel, A., Hamsten, A., Peden, J. F., Seedorf, U., Syvanen, A. C., Tognoni, G., Lakatta, E. G., Sanna, S., Scheet, P., Schlessinger, D., Scuteri, A., Dorr, M., Ernst, F., Felix, S. B., Homuth, G., Lorbeer, R., Reffelmann, T., Rettig, R., 5

6 Volker, U., Galan, P., Gut, I. G., Hercberg, S., Lathrop, G. M., Zelenika, D., Deloukas, P., Soranzo, N., Williams, F. M., Zhai, G., Salomaa, V., Laakso, M., Elosua, R., Forouhi, N. G., Volzke, H., Uiterwaal, C. S., van der Schouw, Y. T., Numans, M. E., Matullo, G., Navis, G., Berglund, G., Bingham, S. A., Kooner, J. S., Connell, J. M., Bandinelli, S., Ferrucci, L., Watkins, H., Spector, T. D., Tuomilehto, J., Altshuler, D., Strachan, D. P., Laan, M., Meneton, P., Wareham, N. J., Uda, M., Jarvelin, M. R., Mooser, V., Melander, O., Loos, R. J. F., Elliott, P., Abecasis, G. R., Caulfield, M., Munroe, P. B. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41(6): , Nienhuis, H. L. A., Westra, J., Smit, A. J., Limburg, P. C., Kallenberg, C. G. M., Bijl, M. AGE and their receptor RAGE in systemic autoimmune diseases: An inflammation propagating factor contributing to accelerated atherosclerosis. Autoimmunity 42(4): , Nijboer, W. N., Schuurs, T. A., Damman, J., van Goor, H., Vaidya, V. S., van der Heide, J. J. H., Leuvenink, H. G. D., Bonventre, J. V., Ploeg, R. J. Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation. American Journal of Transplantation 9(8): , Ochodnicky, P., Henning, R. H., Buikema, H., Kluppel, A. C. A., van Wattum, M., de Zeeuw, D., van Dokkum, R. P. E. Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage. Nephrology Dialysis Transplantation 24(2): , Oeseburg, H., Iusuf, D., van der Harst, P., van Gilst, W. H., Henning, R. H., Roks, A. J. M. Bradykinin Protects Against Oxidative Stress-Induced Endothelial Cell Senescence. Hypertension 53(2): , Oterdoom, L. H., de Vries, A. P. J., Gansevoort, R. T., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. Fasting insulin is a stronger cardiovascular risk factor in women than in men. Atherosclerosis 203(2): , Oterdoom, L. H., de Vries, A. P. J., van Ree, R. M., Gansevoort, R. T., van Son, W. J., van der Heide, J. J. H., Navis, G., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Renal Transplant Recipients Versus the General Population. Transplantation 87(10): , Oterdoom, L. H., Gansevoort, R. T., Schouten, J. P., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population. Atherosclerosis 207(2): , Parving, H. H., Brenner, B. M., McMurray, J. J. V., de Zeeuw, D., Haffner, S. M., Solomon, S. D., Chaturvedi, N., Ghadanfar, M., Weissbach, N., Xiang, Z. H., Armbrecht, J., Pfeffer, M. A. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrology Dialysis Transplantation 24(5): , Perkovic, V., Heerspink, H. L., Ninomiya, T., Cass, A., Neal, B. Blood pressure in dialysis patients-look before we leap reply. Lancet 373(9679): , 6-6- Pfeffer, M. A., Burdmann, E. A., Chen, C. Y., Cooper, M. E., de Zeeuw, D., Eckardt, K. U., Feyzi, J. M., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., Mcgill, J. B., McMurray, J. J. V., Parfrey, P., Parving, H. H., Remuzzi, G., Singh, A. K., Solomon, S. D., Toto, R. A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease. New England Journal of Medicine 361(21): , Pfeffer, M. A., Burdmann, E. A., Chen, C. Y., Cooper, M. E., de Zeeuw, D., Eckardt, K. U., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., McGill, J., McMurray, J. J. V., Parfrey, P., Parving, H. H., Remuzzi, G., Singh, A. K., Solomon, S. D., Toto, R., Uno, H. Baseline Characteristics in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). American Journal of Kidney Diseases 54(1): 59-69, Piers, L. H., Touw, H. R. W., Gansevoort, R., Franssen, C. F. M., Oudkerk, M., Zijlstra, F., Tio, R. A. Relation of Aortic Valve and Coronary Artery Calcium in Patients With Chronic Kidney Disease to the Stage and Etiology of the Renal Disease. American Journal of Cardiology 103(10): , Plomgaard, P., Dullaart, R. P. F., de Vries, R., Groen, A. K., Dahlback, B., Nielsen, L. B. Apolipoprotein M predicts pre-beta-hdl formation: studies in type 2 diabetic and nondiabetic subjects. Journal of Internal Medicine 266(3): , Postma, M. J., de Zeeuw, D. The economic benefits of preventing end-stage renal disease in patients with type 2 diabetes mellitus. Nephrology Dialysis Transplantation 24(10): , Rienstra, H., Boersema, M., Onuta, G., Boer, M. W., Zandvoort, A., van Riezen, M., Rozing, J., van Goor, H., Navis, G. J., Popa, E. R., Hillebrands, J. L. Donor and Recipient Origin of Mesenchymal and Endothelial Cells in Chronic Renal Allograft Remodeling. American Journal of Transplantation 9(3): , Samarska, I. V., van Meurs, M., Buikema, H., Houwertjes, M. C., Wulfert, F. M., Molema, G., Epema, A. H., Henning, R. H. Adjunct Nitrous Oxide Normalizes Vascular Reactivity Changes after Hemorrhagic Shock in Mice under Isoflurane Anesthesia. Anesthesiology 111(3): , Smilde, T. D. J., Damman, K., van der Harst, P., Navis, G., Westenbrink, B. D., Voors, A. A., Boomsma, F., van Veldhuisen, D. J., Hillege, H. L. Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure. Clinical Research in Cardiology 98(2): , Tak, L. M., Bakker, S. J. L., Slaets, J. P. J., Rosmalen, J. G. M. Is highsensitive C-reactive protein a biomarker for functional somatic 6

7 symptoms? A population-based study. Brain Behavior and Immunity 23(7): , ter Bogt, N. C. W., Bemelmans, W. J. E., Beltman, F. W., Broer, J., Smit, A. J., van der Meer, K. Preventing Weight Gain One-Year Results of a Randomized Lifestyle Intervention. American Journal of Preventive Medicine 37(4): , Ulu, N., Henning, R. H., Goris, M., Schoeinaker, R. G., van Gilst, W. H. Effects of Ivabradine and Metoprolol on Cardiac Angiogenesis and Endothelial Dysfunction in Rats With Heart Failure. Journal of Cardiovascular Pharmacology 53(1): 9-17, Ulu, N., Schoemaker, R. G., Henning, R. H., Buikema, H., Teerlink, T., Zijlstra, F. J., Bakker, S. J. L., van Gilst, W. H., Navis, G. Proteinuria-Associated Endothelial Dysfunction Is Strain Dependent. American Journal of Nephrology 30(3): , van den Hoven, M. J., Waanders, F., Rops, A. L., Kramer, A. B., van Goor, H., Berden, J. H., Navis, G., van der Vlag, J. Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species. Nephrology Dialysis Transplantation 24(9): , van der Velde, M., Halbesma, N., de Charro, F. T., Bakker, S. J. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Screening for Albuminuria Identifies Individuals at Increased Renal Risk. Journal of the American Society of Nephrology 20(4): , van Dokkum, R. P. E., Buikema, H. Possible new druggable targets for the treatment of nephrosis Perhaps we should find them in caveolea? Current Opinion in Pharmacology 9(2): , van Goor, H., Melenhorst, W. B. W. H., Turner, A. J., Holgate, S. T. Adamalysins in biology and disease. Journal of Pathology 219(3): , van Goor, H., Leuvenink, H. G. D. The goddess of the waters. Kidney International 75(8): , van Timmeren, M. M., Lems, S. P. M., Hepkema, B. G., Bakker, S. J. L. Anti-Human Leukocyte Antigen Antibodies and Development of Graft Failure After Renal Transplantation. Transplantation 88(12): , van Timmeren, M. M., Lems, S. P. M., Hepkema, B. G., Bakker, S. J. L. Anti-Human Leukocyte Antigen Antibodies and Development of Graft Failure After Renal Transplantation. Transplantation 88(12): , Vegter, S., Perna, A., Hiddema, W., Ruggenenti, P., Remuzzi, G., Navis, G., Postma, M. J. Cost-effectiveness of ACE inhibitor therapy to prevent dialysis in nondiabetic nephropathy: influence of the ACE insertion/deletion polymorphism. Pharmacogenetics and Genomics 19(9): , Visser, A., Dijkstra, G. J., Kuiper, D., de Jong, P. E., Franssen, C. F. M., Gansevoort, R. T., Izaks, G. J., Jager, K. J., Reineveld, S. A. Accepting or declining dialysis: Considerations taken into account by elderly patients with end-stage renal disease. Journal of Nephrology 22(6): , Visser, A., Dijkstra, G. J., Kuiper, D., de Jong, P. E., Franssen, C. F. M., Gansevoort, R. T., Izaks, G. J., Jager, K. J., Reijneveld, S. A. Accepting or declining dialysis: considerations taken into account by elderly patients with end-stage renal disease. Journal of Nephrology 22(6): , Visser, F. W., Krikken, J. A., Muntinga, J. H. J., Dierckx, R. A., Navis, G. J. Rise in Extracellular Fluid Volume During High Sodium Depends on BMI in Healthy Men. Obesity 17(9): , Vogt, L., de Zeeuw, D., Woittiez, A. J. J., Navis, G. Selective cyclooxygenase-2 (COX-2) inhibition reduces proteinuria in renal patients. Nephrology Dialysis Transplantation 24(4): , Waanders, F., Vaidya, V. S., van Goor, H., Leuvenink, H., Damman, K., Hamming, I., Bonventre, J. V., Vogt, L., Navis, G. Effect of Renin-Angiotensin-Aidosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease: A Post Hoc Analysis of a Randomized Controlled Trial. American Journal of Kidney Diseases 53(1): 16-25, Waanders, F., Rienstra, H., Boer, M. W., Zandvoort, A., Rozing, J., Navis, G., van Goor, H., Hillebrands, J. L. Spironolactone ameliorates transplant vasculopathy in renal chronic transplant dysfunction in rats. American Journal of Physiology-Renal Physiology 296(5): F1072-F1079, Westendorp, B., Hamming, I., Szymanski, M. K., Navis, G., van Goor, H., Buikema, H., van Gilst, W. H., Schoemaker, R. G. Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor. European Journal of Pharmacology 602(2-3): , Witte, E. C., Heerspink, H. J. L., de Zeeuw, D., Bakker, S. J. L., de Jong, P. E., Gansevoort, R. First Morning Voids Are More Reliable Than Spot Urine Samples to Assess Microalbuminuria. Journal of the American Society of Nephrology 20(2): , Wolffenbuttel, B. H. R., Klaff, L. J., Bhushan, R., Fahrbach, J. L., Jiang, H., Martin, S. Initiating insulin therapy in elderly patients with Type 2 diabetes: efficacy and safety of lispro mix 25 vs. basal insulin combined with oral glucose-lowering agents. Diabetic Medicine 26(11): , Wong, L. S., Windt, W. A., Roks, A. J., van Dokkum, R. P., Schoemaker, R. G., de Zeeuw, D., Henning, R. H. Renal failure 7

8 induces telomere shortening in the rat heart. Netherlands Heart Journal 17(5): , Xu, Y., Henning, R. H., Sandovici, M., van der Want, J. J., van Gilst, W. H., Buikema, H. Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT(1)- and epidermal growth factor-receptor function. European Journal of Heart Failure 11(3): , 8

9 CARDIOVASCULAR CENTER -CVC Dissertations Broers, C. J. M. De nurse practitioner: verpleegkundig specialist tussen care en cure. (2009) Veldhuisen, D. J., Jaarsma, T., and Umans, V. A. W. M. Damman, K. Cardiorenal interaction in heart failure. (2009) Hillege, H. L., Veldhuisen, D. J., Navis, G. J., and Voors, A. A. Meijering, B. D. M. Ultrasound and microbubble targeted delivery : exploring the mechanism and its therapeutic potential. (2009) Henning, R. H., van Gilst, W. H., and Deelman, L. E. Piers, L. H. Computed tomography for the evaluation of the aortic valve and coronary arteries. (2009) Zijlstra, F. and Tio, R. Ulu, N. Vascular function in chronic end-organ damage : pharmacological characterization of vasomotor function in systemic vasculature. (2009) Henning, R. H., van Gilst, W. H., Buikema, H., and Schoemaker, R. G. van der Vleuten, P. A. Left ventricular function after STEMI : developments in diagnostics and cell therapy. (2009) Zijlstra, F. and Tio, R. A. Journal articles Buck, S. Optimization of cardiac resynchronization therapy in atrial fibrillation and sinus rhythm. edited by I. C. van Gelder, D. J. Veldhuisen, and A. H. Maass, 2009, Aalberts, J. J. J., Boonstra, P. W., van den Berg, M. P., Waterbolk, T. W. In-hospital mortality and three-year survival after repaired acute type A aortic dissection. Netherlands Heart Journal 17(6): , Ahmed, S., Crijns, H. J. G. M., van Gelder, I. C. Treatment With Amiodarone to Prevent Atrial Fibrillation Reply. JAMA - Journal of the American Medical Association 301(10): 1020, Al-Ansari, S., Zeebregts, C. J., Slart, R. H. J. A., Peppelenbosch, M., Tio, R. A. Galectins in Atherosclerotic Disease. Trends in Cardiovascular Medicine 19(5): , Al Ansari, S., Zeebregts, C. J., Slart, R. H. J. A., Peppelenbosch, M., Tio, R. A. Galectins in Atherosclerotic Disease. Trends in Cardiovascular Medicine 19(5): , Altena, R., Perik, P. J., van Veldhuisen, D. J., de Vries, E. G. E., Gietema, J. A. Cardiovascular toxicity caused by cancer treatment: strategies for early detection. Lancet Oncology 10(4): , Anker, S. D., Voors, A., Okonko, D., Clark, A. L., James, M. K., von Haehling, S., Kjekshus, J., Ponikowski, P., Dickstein, K. Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial. European Heart Journal 30(11): , Annema, C., Luttik, M. L., Jaarsma, T. Do Patients With Heart Failure Need a Case Manager? Journal of Cardiovascular Nursing 24(2): , Annema, C., Luttik, M. L., Jaarsma, T. Reasons for readmission in heart failure: Perspectives of patients, caregivers, cardiologists, and heart failure nurses. Heart & Lung 38(5): , Backlund, M., Paukku, K., Daviet, L., de Boer, R. A., Valo, E., Hautaniemi, S., Kalkkinen, N., Ehsan, A., Kontula, K. K., Lehtonen, J. Y. A. Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase. Nucleic Acids Research 37(7): , Bartels, A. L., Zeebregts, C. J., Bijl, M., Tio, R. A., Slart, R. H. J. A. Fused FDG-PET and MRI imaging of Takayasu arteritis in vertebral arteries. Annals of Nuclear Medicine 23(8): , Beghetti, M., Haworth, S. G., Bonnet, D., Barst, R. J., Acar, P., Fraisse, A., Ivy, D. D., Jais, X., Schulze-Neick, I., Galie, N., Morganti, A., Dingemanse, J., Kusic-Pajic, A., Berger, R. M. F. Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study. British Journal of Clinical Pharmacology 68(6): , Belonje, A. M. S., Westenbrink, B. D., Voors, A. A., von Haehling, S., Ponikowski, P., Anker, S. D., van Veldhuisen, D. J., Dickstein, K. Erythropoietin levels in heart failure after an acute myocardial infarction: Determinants, prognostic value, and the effects of captopril versus losartan. American Heart Journal 157(1): 91-96, Bhuiyan, Z. A., Jongbloed, J. D. H., van der Smagt, J., Lombardi, P. M., Wiesfeld, A. C. P., Nelen, M., Schouten, M., Jongbloed, R., Cox, M. G. P. J., van Wolferen, M., Rodriguez, L. M., van Gelder, I. C., Bikker, H., Suurmeijer, A. J. H., van den Berg, M. P., Mannens, 9

10 M. M. A. M., Hauer, R. N. W., Wilde, A. A. M., van Tintelen, J. P. Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients Results From a Multicenter Study. Circulation- Cardiovascular Genetics 2(5): 418-U22, Bhuiyan, Z. A., Jongbloed, J. D. H., van der Smagt, J., Lombardi, P. M., Wiesfeld, A. C. P., Nelen, M., Schouten, M., Jongbloed, R., Cox, M. G. P. J., van Wolferen, M., Rodriguez, L. M., van Gelder, I. C., Bikker, H., Suurmeijer, A. J. H., van den Berg, M. P., Mannens, M. M. A. M., Hauer, R. N. W., Wilde, A. A. M., van Tintelen, J. P. Desmoglein-2 and Desmocollin-2 Mutations in Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomypathy Patients Results From a Multicenter Study. Circulation-Cardiovascular Genetics 2(5): 418-U22, Broers, C. J. M., Sinclair, N., van der Ploeg, T. J., Jaarsma, T., van Veldhuisen, D. J., Umans, V. A. W. M. The post-infarction nurse practitioner project A prospective study comparing nurse intervention with conventional care in a non-high-risk myocardial infarction population. Netherlands Heart Journal 17(2): 61-67, Brugemann, J., van der Bij, W., Verschuuren, E. A. M., Klungel, A. A., van der Horst, I. C. C., Erasmus, M. E., Kerstjens, H. A. M., van Veldhuisen, D. J., Zijlstra, F. Experience with combined heartlung transplant at the University Medical Center Groningen. Nederlands Tijdschrift voor Geneeskunde 153(27): , Buck, S., Maass, A. H., van Veldhuisen, D. J., van Gelder, I. C. Cardiac resynchronisation therapy and the role of optimal device utilisation. Netherlands Heart Journal 17(9): , Burzotta, F., De Vita, M., Gu, Y. L. L., Isshiki, T., Lefevre, T., Kaltoft, A., Dudek, D., Sardella, G., Orrego, P. S., Antoniucci, D., De Luca, L., Biondi-Zoccai, G. G. L., Crea, F., Zijlstra, F. Clinical impact of thrombectomy in acute ST-elevation myocardial infarction: an individual patient-data pooled analysis of 11 trials. European Heart Journal 30(18): , Carballo, S., Robinson, P., Otway, R., Fatkin, D., Jongbloed, J. D. H., de Jonge, N., Blair, E., van Tintelen, J. P., Redwood, C., Watkins, H. Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy. Circulation Research 105(4): 375- U116, Cleland, J. G. F., McMurray, J. J. V., Kjekshus, J., Cornel, J. H., Dunselman, P., Fonseca, C., Hjalmarson, A., Korewicki, J., Lindberg, M., Ranjith, N., van Veldhuisen, D. J., Waagstein, F., Wedel, H., Wikstrand, J. Plasma Concentration of Amino- Terminal Pro-Brain Natriuretic Peptide in Chronic Heart Failure: Prediction of Cardiovascular Events and Interaction With the Effects of Rosuvastatin A Report From CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure). Journal of the American College of Cardiology 54(20): , Cohen-Solal, A., Kotecha, D., van Veldhuisen, D. J., Babalis, D., Bohm, M., Coats, A. J., Roughton, M., Poole-Wilson, P., Tavazzi, L., Flather, M. Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial. European Journal of Heart Failure 11(9): , Cox, M. G. P. J., van der Smagt, J. J., Wilde, A. A. M., Wiesfeld, A. C. P., Atsma, D. E., Nelen, M. R., Rodriguez, L. M., Loh, P., Cramer, M. J., Doevendans, P. A., van Tintelen, J. P., De Bakker, J. M. T., Hauer, R. N. W. New ECG Criteria in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Circulation-Arrhythmia and Electrophysiology 2(5): , Damman, K., Hillege, H. L., van Veldhuisen, D. J. Albuminuria in heart failure: a CHARMing new risk factor? Lancet 374(9689): , Damman, K., Jaarsma, T., Voors, A. A., Navis, G., Hillege, H. L., van Veldhuisen, D. J. Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: results from the Coordinating Study Evaluating Outcome of Advising and Counseling in Heart Failure (COACH). European Journal of Heart Failure 11(9): , Damman, K., van Veldhuisen, D. J., Hillege, H. L. Cardiac Resynchronization Therapy Improves Renal Function: Importance of Forward and Backward Failure. Journal of Cardiac Failure 15(1): 78-79, Damman, K., van Deursen, V. M., Navis, G., Voors, A. A., van Veldhuisen, D. J., Hillege, H. L. Increased Central Venous Pressure Is Associated With Impaired Renal Function and Mortality in a Broad Spectrum of Patients With Cardiovascular Disease. Journal of the American College of Cardiology 53(7): , Dasselaar, J. J., Slart, R. H. J. A., Knip, M., Pruim, J., Tio, R. A., McIntyre, C. W., de Jong, P. E., Franssen, C. F. M. Haemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrology Dialysis Transplantation 24(2): , de Boer, R. A., Voors, A. A., Muntendam, P., van Gilst, W. H., van Veldhuisen, D. J. Galectin-3: a novel mediator of heart failure development and progression. European Journal of Heart Failure 11(9): , de Boer, R. A., van der Harst, P., van Veldhuisen, D. J., van den Berg, M. P. Pharmacogenetics in heart failure: promises and challenges. Expert Opinion on Pharmacotherapy 10(11): , de Jong, R. M., Tio, R. A., van der Harst, P., Voors, A. A., Koning, P. M., Zeebregts, C. J. A. M., van Veldhuisen, D. J., Dierckx, R. A. J. O., Slart, R. H. J. A. Ischemic patterns assessed by positron emission tomography predict adverse outcome in patients with 10

11 idiopathic dilated cardiomyopathy. Journal of Nuclear Cardiology 16(5): , De Smedt, R. H. E., Denig, P., Haaijer-Ruskamp, F. M., Jaarsma, T. Perceived medication adverse effects and coping strategies reported by chronic heart failure patients. International Journal of Clinical Practice 63(2): , de Vries, B. M. W., Hillebrands, J. L., van Dam, G. M., Tio, R. A., de Jong, J. S., Slart, R. H. J. A., Zeebregts, C. J. Multispectral Near- Infrared Fluorescence Molecular Imaging of Matrix Metalloproteinases in a Human Carotid Plaque Using a Matrix- Degrading Metalloproteinase-Sensitive Activatable Fluorescent Probe. Circulation 119(20): E534-E536, Deuling, J. H. H., Smit, M. D., Maass, A. H., van den Heuvel, A. F. M., Nieuwland, W., Zijlstra, F., van Gelder, I. C. The value and limitations of a wound inspection clinic after cardiac device implantation. European Journal of Cardiovascular Nursing 8(4): , Dickinson, M. G., Scholvinck, E. H., Boonstra, A., Vonk- Noordegraaf, A., Snijder, R. J., Berger, R. M. F. Low Complication Rates With Totally Implantable Access Port Use in Epoprostenol Treatment of Pulmonary Hypertension. Journal of Heart and Lung Transplantation 28(3): , Dickstein, K., Bogale, N., Priori, S., Auricchio, A., Cleland, J. G., Gitt, A., Limbourg, T., Linde, C., van Veldhuisen, D. J., Brugada, J. The European cardiac resynchronization therapy survey. European Heart Journal 30(20): , Dieperink, W., Weelink, E. E. M., van der Horst, I. C. C., De Vos, R., Jaarsma, T., Aarts, L. P. H. J., Zijlstra, F., Nijsten, M. W. N. Treatment of presumed acute cardiogenic pulmonary oedema in an ambulance system by nurses using Boussignac continuous positive airway pressure. Emergency Medicine Journal 26(2): , Duffels, M. G. J., van der Plas, M. N., Surie, S., Winter, M. M., Bouma, B. J., Groenink, M., van Dijk, A. P. J., Hoendermis, E. S., Berger, R. M. F., Bresser, P., Mulder, B. J. M. Bosentan in pulmonary arterial hypertension: a comparison between congenital heart disease and chronic pulmonary embolism. Netherlands Heart Journal 17(9): 334-+, Duffels, M. G. J., Vis, J. C., van Loon, R. L. E., Berger, R. M. F., Hoendermis, E. S., van Dijk, A. P. J., Bouma, B. J., Mulder, B. J. M. Down patients with Eisenmenger syndrome: Is bosentan treatment an option? International Journal of Cardiology 134(3): , Duffels, M. G. J., Hardziyenka, M., Surie, S., de Bruin-Bon, R. H. A. C., Hoendermis, E. S., van Dijk, A. P. J., Bouma, B. J., Tan, H. L., Berger, R. M. F., Bresser, P., Mulder, B. J. M. Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension. European Journal of Echocardiography 10(3): , Duffels, M. G. J., Vis, J. C., van Loon, R. L. E., Nieuwkerk, P. T., van Dijk, A. P. J., Hoendermis, E. S., de Bruin-Bon, R. H. A. C., Bouma, B. J., Bresser, P., Berger, R. M. F., Mulder, B. J. M. 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Serotonin Transporter Gene, Depressive Symptoms, and Interleukin-6. Circulation-Cardiovascular Genetics 2(6): 614-U205, Su, S. Y., Lampert, R., Zhao, J. Y., Bremner, J. D., Miller, A., Snieder, H., Lee, F., Khan, D., Goldberg, J., Vaccarino, V. Pleiotropy of C- Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins. American Journal of Cardiology 104(12): , Tan, E. S., Jessurun, G. A. J., Anthonio, R. L., Slart, R. H. J. A., Zijlstra, F., Tio, R. A. Electromechanical mapping of the left ventricle: 15

16 possible tool for online decision making in the catheterization laboratory. Journal of Cardiovascular Medicine 10(5): , Tan, E. S., Mulder, B. A., Rienstra, M., Wiesfeld, A. C. P., Ahmed, S., Zijlstra, F., van Gelder, I. C. Pulmonary vein isolation of symptomatic refractory paroxysmal and persistent atrial fibrillation A single centre and single operator experience in the Netherlands. Netherlands Heart Journal 17(10): , Teerlink, J. R., Metra, M., Felker, G. M., Ponikowski, P., Voors, A. A., Weatherley, B. D., Marmor, A., Katz, A., Grzybowski, J., Unemori, E., Teichman, S. L., Cotter, G. Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study. Lancet 373(9673): , Teichman, S. L., Unemori, E., Dschietzig, T., Conrad, K., Voors, A. A., Teerlink, J. R., Felker, G. M., Metra, M., Cotter, G. Relaxin, a pleiotropic vasodilator for the treatment of heart failure. Heart Failure Reviews 14(4): , Tio, R. A., Dabeshlim, A., Siebelink, H. M. J., de Sutter, J., Hillege, H. L., Zeebregts, C. J., Dierckx, R. A. J. O., van Veldhuisen, D. J., Zijlstra, F., Slart, R. H. J. A. Comparison Between the Prognostic Value of Left Ventricular Function and Myocardial Perfusion Reserve in Patients with Ischemic Heart Disease. Journal of Nuclear Medicine 50(2): , Tio, R. A., Slart, R. H. J. A., de Boer, R. A., van der Vleuten, P. A., de Jong, R. M., van Wijk, L. M., Willems, T., Lubbers, D. D., Voors, A. A., van Veldhuisen, D. J. Reduced regional myocardial perfusion reserve is associated with impaired contractile performance in idiopathic dilated cardiomyopathy. Netherlands Heart Journal 17(12): , Ulu, N., Henning, R. H., Goris, M., Schoeinaker, R. G., van Gilst, W. H. Effects of Ivabradine and Metoprolol on Cardiac Angiogenesis and Endothelial Dysfunction in Rats With Heart Failure. Journal of Cardiovascular Pharmacology 53(1): 9-17, Ulu, N., Schoemaker, R. G., Henning, R. H., Buikema, H., Teerlink, T., Zijlstra, F. J., Bakker, S. J. L., van Gilst, W. H., Navis, G. Proteinuria-Associated Endothelial Dysfunction Is Strain Dependent. American Journal of Nephrology 30(3): , van den Berg, M. P., de Boer, R. A., van Tintelen, J. P. Brugada Syndrome or Brugada Electrocardiogram? Journal of the American College of Cardiology 53(17): 1569, van der Meer, P., van Veldhuisen, D. J. Anaemia and renal dysfunction in chronic heart failure. Heart 95(21): , van der Meer, P., Groenveld, H. F., Januzzi, J. L., van Veldhuisen, D. J. Erythropoietin treatment in patients with chronic heart failure: a meta-analysis. Heart 95(16): , van der Meer, P., van Veldhuisen, D. J. Risk of bias in meta-analysis on erythropoietin-stimulating agents in heart failure Reply. Heart 95(15): 1279, van der Meer, P., van Veldhuisen, D. J. The authors' reply. Heart 95(15): 1279, van der Roest, W. P., Pennings, J. M., Bakker, M., van den Berg, M. P., van Tintelen, J. P. Family Letters Are an Effective Way to Inform Relatives About Inherited Cardiac Disease. American Journal of Medical Genetics Part A 149A(3): , van der Vleuten, P. A., de Jonge, G. J., Lubbers, D. D., Tio, R. A., Willems, T. P., Oudkerk, M., Zijlstra, F. Evaluation of global left ventricular function assessment by dual-source computed tomography compared with MRI. European Radiology 19(2): , van der Vleuten, P. A., Vogelzang, M., Svilaas, T., van der Horst, I. C. C., Tio, R. A., Zijlstra, F. Predictive value of Q waves on the 12- lead electrocardiogram after reperfusion therapy for ST elevation myocardial infarction. Journal of Electrocardiology 42(4): , van der Wall, E. E., de Boer, M. J., Doevendans, P. A., Wilde, A. A., Zijlstra, F. Major achievements in cardiology in the past century: influence on Dutch cardiovascular medicine. Netherlands Heart Journal 17(4): , van der Zwaag, P. A., Jongbloed, J. D. H., van den Berg, M. P., van der Smagt, J. J., Jongbloed, R., Bikker, H., Hofstra, R. M. W., van Tintelen, J. P. A Genetic Variants Database for Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Human Mutation 30(9): , van der Zwaag, P. A., Jongbloed, J. D. H., van den Berg, M. P., Jonkman, M. F., van Tintelen, J. P. Letter regarding the article: "R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia associated with arrhythmogenic right ventricular cardiomyopathy" by Valenzise et al. European Journal of Medical Genetics 52(4): 277, van Loon, R. L. E., Roofthooft, M. T. R., van Osch-Gevers, M., Delhaas, T., Strengers, J. L. M., Blom, N. A., Backx, A., Berger, R. M. F. Clinical Characterization of Pediatric Pulmonary Hypertension: Complex Presentation and Diagnosis. Journal of Pediatrics 155(2): , van Tintelen, J. P., Hauer, R. N. W. New test for arrhythmogenic right ventricular cardiomyopathy. Nature Reviews Cardiology 6(7): , van Tintelen, J. P., van Gelder, I. C., Asimaki, A., Suurmijer, A. J. H., Wiesfeld, A. C. P., Jongbloed, J. D. H., van den Wijngaard, A., 16

17 Kuks, J. B. M., Van Spaendonck-Zwarts, K. Y., Notermans, N., Boven, L., van den Heuvel, F., Veenstra-Knol, H. E., Saffitz, J. E., Hofstra, R. M. W., van den Berg, M. P. Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm 6(11): , van Veldhuisen, D. J., Cohen-Solal, A., Bohm, M., Anker, S. D., Babalis, D., Roughton, M., Coats, A. J. S., Poole-Wilson, P. A., Flather, M. D. Beta-Blockade With Nebivolol in Elderly Heart Failure Patients With Impaired and Preserved Left Ventricular Ejection Fraction Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure). Journal of the American College of Cardiology 53(23): , van Veldhuisen, D. J., Maass, A. H., Priori, S. G., Stolt, P., van Gelder, I. C., Dickstein, K., Swedberg, K. Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to European Journal of Heart Failure 11(12): , van Veldhuisen, D. J., de Boer, R. A. Low-dose digoxin in heart failure. International Journal of Cardiology 136(1): 90-91, Vis, J. C., Thoonsen, H., Duffels, M. G., de Bruin-Bon, R. A., Huisman, S. A., van Dijk, A. P., Hoendermis, E. S., Berger, R. M., Bouma, B. J., Mulder, B. J. Six-Minute Walk Test in Patients With Down Syndrome: Validity and Reproducibility. Archives of Physical Medicine and Rehabilitation 90(8): , Vlaar, P. J., Zijlstra, F. Angiographic Restenosis and Clinical Recurrence After Sirolimus- and Paclitaxel-Eluting Stent Implantation. JACC: Cardiovascular Interventions 2(8): , Vlaar, P. J., Svilaas, T., Damman, K., de Smet, B. J. G. L., Hillege, H. L., Zijlstra, F., Tijssen, J. G. P. Response to Letter Regarding Article, "Impact of Pretreatment With Clopidogrel on Initial Patency and Outcome in Patients Treated With Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Systematic Review. Circulation 120(4): E27, Vlaar, P. J., Zijlstra, F. Angiographic Restenosis and Clinical Recurrence After Sirolimus- and Paclitaxel-Eluting Stent Implantation. JACC: Cardiovascular Interventions 2(8): , Vogelzang, M., Vlaar, P. J., Svilaas, T., Amo, D., Nijsten, M. W. N., Zijlstra, F. Computer-assisted myocardial blush quantification after percutaneous coronary angioplasty for acute myocardial infarction: a substudy from the TAPAS trial. European Heart Journal 30(5): , Voors, A. A., von Haehling, S., Anker, S. D., Hillege, H. L., Struck, J., Hartmann, O., Bergmann, A., Squire, I., van Veldhuisen, D. J., Dickstein, K. C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. European Heart Journal 30(10): , Wang, X., Ding, X., Su, S., Spector, T. D., Mangino, M., Iliadou, A., Snieder, H. Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction. Diabetologia 52(12): , Wang, X. L., Ding, X. H., Su, S. Y., Yan, W. L., Harshfield, G., Treiber, F., Snieder, H. Genetic influences on daytime and night-time blood pressure: similarities and differences. Journal of Hypertension 27(12): , Wang, X. L., Ding, X. H., Su, S. Y., Li, Z. B., Riese, H., Thayer, J. F., Treiber, F., Snieder, H. Genetic influences on heart rate variability at rest and during stress. Psychophysiology 46(3): , Westendorp, B., Hamming, I., Szymanski, M. K., Navis, G., van Goor, H., Buikema, H., van Gilst, W. H., Schoemaker, R. G. Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor. European Journal of Pharmacology 602(2-3): , Willemsen, H. M., de Jong, G., Tio, R. A., Nieuwland, W., Kema, I. P., van der Horst, I. C. C., Oudkerk, M., Zijlstra, F. Quick identification of acute chest pain patients study (QICS). BMC Cardiovascular Disorders 9 AR 24 DI / Willemsen, H. M., van der Horst, I. C. C., Nieuwland, W., Slart, R. J. H. A., Zeebregts, C. J., de Boef, E., Schuitemaker, J. H. N., Zijlstra, F., Tio, R. A. The diagnostic value of soluble CD163 in patients presenting with chest pain. Clinical Biochemistry 42(16-17): , Winter, M. M., Bouma, B. J., Groenink, M., Konings, T. C., Tijssen, J. G. P., van Veldhuisen, D. J., Mulder, B. J. M. Latest insights in therapeutic options for systemic right ventricular failure: a comparison with left ventricular failure. Heart 95(12): , Wong, L. S., Windt, W. A., Roks, A. J., van Dokkum, R. P., Schoemaker, R. G., de Zeeuw, D., Henning, R. H. Renal failure induces telomere shortening in the rat heart. Netherlands Heart Journal 17(5): , Wong, L. S. M., van der Harst, P., de Boer, R. A., Codd, V., Huzen, J., Samani, N. J., Hillege, H. L., Voors, A. A., van Gilst, W. H., Jaarsma, T., van Veldhuisen, D. J. Renal dysfunction is associated with shorter telomere length in heart failure. Clinical Research in Cardiology 98(10): , Wong, L. S. M., Oeseburg, H., de Boer, R. A., van Gilst, W. H., van Veldhuisen, D. J., van der Harst, P. Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing. Cardiovascular Research 81(2): , 17

18 Xu, Y., Henning, R. H., Sandovici, M., van der Want, J. J., van Gilst, W. H., Buikema, H. Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT(1)- and epidermal growth factor-receptor function. European Journal of Heart Failure 11(3): , Yap, S. C., Drenthen, W., Meijboom, F. J., Moons, P., Mulder, B. J. M., Vliegen, H. W., van Dijk, A. P. J., Jaddoe, V. W. V., Steegers, E. A. P., Roos-Hesselink, J. W., Pieper, P. G. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect. Bjog - an International Journal of Obstetrics and Gynaecology 116(12): , 18

19 GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD - GRIAC Dissertaties Abello, N. J-R. Chemical labeling for the analysis of proteins, peptides and metabolites by mass spectroscopy. (2009) Bischoff, R. P. H. and Postma, D. S. Brusse-Keizer, M. G. J. COPD excacerbations. Treatment and outcome. (2009) van der Palen, J. and Kerstjens, H. A. M. Dijkstra, A. Lung function impairment in asthma : contributing risk factors and gene polymorphisms. (2009) Postma, D. S., Timens, W., ten Hacken, N. H. T., and Vonk, J. M. Flokstra-de Blok, B. M. J. Development, valdidation and outcome of health-related quality of life questionnairies for food allergic patients. (2009) Dubois, A. E. J., Duiverman, E. J., and Vlieg- Boerstra, B. J. Oude Elberink, H. Quality of Life in Insect venom allergy. (2009) Dubois, A. E. J. and de Monchy, J. G. R. Reijmerink, N. E. A Search for missing pieces of the puzzle; the development of asthma and atopy. (2009) Postma, D. S., Brunekreef, B., Koppelman, G. H., Kerkhof, M., and Gerritsen, J. Siedlinski, M. I. Genetic and environmental determinants of lung function in the general population. (2009) Boezen, H. M., Postma, D. S., and Smit, H. A. van der Toorn, M. Cigarette smoke-induced mitochondrial dysfunction and oxidative stress in. (2009) Kauffman, H. F., Gans, R. O. B., Koëter, G. H., Slebos, D. J., and Bakker, S. J. L. Journal articles Barton, S. J., Koppelman, G. H., Vonk, J. M., Browning, C. A., Nolte, I. M., Stewart, C. E., Bainbridge, S., Mutch, S., Rose-Zerilli, M. J., Postma, D. S., Maniatis, N., Henry, A. P., Hall, I. P., Holgate, S. T., Tighe, P., Holloway, J. W., Sayers, I. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. Journal of Allergy and Clinical Immunology 123(6): , Bateman, E. D., Rennard, S., Barnes, P. J., Dicpinigaitis, P. V., Gosens, R., Gross, N. J., Nadel, J. A., Pfeifer, M., Racke, K., Rabe, K. F., Rubin, B. K., Welte, T., Wessler, I. Alternative mechanisms for tiotropium. Pulmonary Pharmacology & Therapeutics 22(6): , Bathoorn, E., Liesker, J. J. W., Postma, D. S., Koeter, G. H., van der Toorn, M., van der Heide, S., Ross, H. A., van Oosterhout, A. J. M., Kerstjens, H. A. M. Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation. International Journal of COPD 4(1): , Blacquiere, M. J., Timens, W., Melgert, B. N., Geerlings, M., Postma, D. S., Hylkema, M. N. Maternal smoking during pregnancy induces airway remodelling in mice offspring. European Respiratory Journal 33(5): , Boelens, M. C., van den Berg, A., Fehrmann, R. S. N., Geerlings, M., de Jong, W. K., Meerman, G. J. T., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M. Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. Journal of Pathology 218(2): , Boelens, M. C., Kok, K., van der Vlies, P., van der Vries, G., Sietsma, H., Timens, W., Postma, D. S., Groen, H. J. M., van den Berg, A. Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer 66(3): , Boezen, H. M. Genome-wide association studies: What do they teach us about asthma and chronic obstructive pulmonary disease? Proceedings of the American Thoracic Society 6(8): , Bossenbrock, L., ten Thicken, N. H. T., van der Bij, W., Verschuuren, E. A. M., Koeter, G. H., de Greef, M. H. G. Cross-sectional Assessment of Daily Physical Activity in Chronic Obstructive Pulmonary Disease Lung Transplant Patients. Journal of Heart and Lung Transplantation 28(2): , Brandsma, C. A., Hylkema, M. N., Geerlings, M., van Geffen, W. H., Postma, D. S., Timens, W., Kerstjens, H. A. M. Increased levels of (class switched) memory B cells in peripheral blood of current smokers. Respiratory Research 10 AR 108 DI / Broekema, M., ten Hacken, N. H. T., Volbeda, F., Lodewijk, M. E., Hylkema, M. N., Postma, D. S., Timens, W. Airway Epithelial Changes in Smokers but Not in Ex-Smokers with Asthma. American Journal of Respiratory and Critical Care Medicine 180(12): , Broekema, M., ten Hacken, N. H. T., Volbeda, F., Lodewijk, M. E., Hylkema, M. N., Postma, D. S., Timens, W. Airway Epithelial Changes in Smokers but Not in Ex-Smokers with Asthma. 19

20 American Journal of Respiratory and Critical Care Medicine 180(12): , Brugemann, J., van der Bij, W., Verschuuren, E. A. M., Klungel, A. A., van der Horst, I. C. C., Erasmus, M. E., Kerstjens, H. A. M., van Veldhuisen, D. J., Zijlstra, F. Experience with combined heartlung transplant at the University Medical Center Groningen. Nederlands Tijdschrift voor Geneeskunde 153(27): , Brusselle, G. G., Demoor, T., Bracke, K. R., Brandsma, C. A., Timens, W. Lymphoid follicles in (very) severe COPD: beneficial or harmful? European Respiratory Journal 34(1): , Camp, P. G., O'Donnell, D. E., Postma, D. S. Chronic obstructive pulmonary disease in men and women: Myths and reality. Proceedings of the American Thoracic Society 6(6): , Caudri, D., Wijga, A., Scholtens, S., Kerkhof, M., Gerritsen, J., Ruskamp, J. M., Brunekreef, B., Smit, H. A., de Jongste, J. C. Early Daycare Is Associated with an Increase in Airway Symptoms in Early Childhood but Is No Protection against Asthma or Atopy at 8 Years. American Journal of Respiratory and Critical Care Medicine 180(6): , Caudri, D., Wijga, A., Schipper, C. M. A., Hoekstra, M., Postma, D. S., Koppelman, G. H., Brunekreef, B., Smit, H. A., de Jongste, J. C. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age. Journal of Allergy and Clinical Immunology 124(5): , Cerveri, I., Corsico, A. G., Accordini, S., Cervio, G., Ansaldo, E., Grosso, A., Niniano, R., Tegomo, E. T., Anto, J. M., Kunzli, N., Janson, C., Sunyer, J., Svanes, C., Heinrich, J., Schouten, J. P., Wjst, M., Pozzi, E., de Marco, R. What defines airflow obstruction in asthma? European Respiratory Journal 34(3): , Dekkers, B. G. J., Schaafsma, D., Tran, T., Zaagsma, J., Meurs, H. Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype. American Journal of Respiratory Cell and Molecular Biology 41(4): , Dijkstra, A., Postma, D. S., Noordhoek, J. A., Lodewijk, M. E., Kauffman, H. F., ten Hacken, N. H. T., Timens, W. Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung. Virchows Archiv 454(4): , Duiverman, M. L., de Boer, E. W. J., van Eykern, L. A., de Greef, M. H. G., Jansen, D. F., Wempe, J. B., Kerstjens, H. A. M., Wijkstra, P. J. Respiratory muscle activity and dyspnea during exercise in chronic obstructive pulmonary disease. Respiratory Physiology & Neurobiology 167(2): , DunnGalvin, A., Chang, W. C., Laubach, S., Steele, P. H., Dubois, A. E. J., Burks, A. W., Hourihane, J. O. Profiling Families Enrolled in Food Allergy Immunotherapy Studies. Pediatrics 124(3): E503- E509, Effing, T., Kerstjens, H., van der Valk, P., Zielhuis, G., van der Palen, J. (Cost)-effectiveness of self-treatment of exacerbations on the severity of exacerbations in patients with COPD: the COPE II study. Thorax 64(11): , Effing, T. W., Kerstjens, H. A. M., Monninkhof, E. M., van der Valk, P. D. L. P., Wouters, E. F. M., Postma, D. S., Zielhuis, G. A., van der Palen, J. Definitions of Exacerbations Does It Really Matter in Clinical Trials on COPD? Chest 136(3): , Flokstra-de Blok, B. M. J., van der Meulen, G. N., DunnGalvin, A., Vlieg-Boerstra, B. J., Elberink, J. N. G. O., Duiverman, E. J., Hourihane, J. O., Dubois, A. E. J. Development and validation of the Food Allergy Quality of Life Questionnaire - Adult Form. Allergy 64(8): , Flokstra-de Blok, B. M. J., DunnGalvin, A., Vlieg-Boerstra, B. J., Oude Elberink, J. N. G., Duiverman, E. J., Hourihane, J. O., Dubois, A. E. J. Development and validation of a self-administered Food Allergy Quality of Life Questionnaire for children. Clinical and Experimental Allergy 39(1): , Flokstra-de Blok, B. M. J., Oude Elberink, J. N. G., Vlieg-Boerstra, B. J., Duiverman, E. J., Dubois, A. E. J. Measuring health-related quality of life: Fundamental methodological issues. Clinical and Experimental Allergy 39(11): 1774, Flokstra-de Blok, B. M. J., Dubois, A. E. J. Quality of life in food allergy: valid scales for children and adults. Current Opinion in Allergy and Clinical Immunology 9(3): , Gehring, U., Oldenwening, M., Brunekreef, B., Wieringa, M. H., Kerkhof, M., Smit, H. A., van der Ent, C. K., de Jongste, J. C. The impact of ambient NO on online measurements of exhaled and nasal NO: The PIAMA study. Pediatric Allergy and Immunology 20(7): , Gerritsen, J. The Brussels Declaration. European Respiratory Journal 34(1): 290, Gkoumassi, E., Dekkers, B. G. J., Droge, M. J., Elzinga, C. R. S., Hasenbosch, R. E., Meurs, H., Nelemans, S. A., Schmidt, M., Zaagsma, J. (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. Naunyn- Schmiedebergs Archives of Pharmacology 380(1): 67-77, Goossens, L. M. A., Riemersma, R. A., Postma, D. S., van der Molen, T., Rutten-van Molken, M. P. M. H. An Economic Evaluation of Budesonide/Formoterol for Maintenance and Reliever Treatment in Asthma in General Practice. Advances in Therapy 26(9): , Gosens, R., Rieks, D., Meurs, H., Ninaber, D. K., Rabe, K. F., Nanninga, J., Kolahian, S., Halayko, A. J., Hiemstra, P. S., Zuyderduyn, S. Muscarinic M3 receptor stimulation increases 20