Annual Publication Report

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1 Annual Publication Report 2008 TABLE OF CONTENTS 3 GRONINGEN INSTITUTE FOR KIDNEY DISEASES GIKD 8 CARDIOVASCULAR CENTER CVC 16 INSTITUTE FOR PHARMACOEPIDEMIOLOGY AND DRUG POLICY PEDP 20 GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD GRIAC 24 CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES CLDS 30 INSTITUTE FOR TRANSPLANTATION, IMMUNITY AND INFLAMMATION TRIO 41 NORTHERN NETHERLANDS ONCOLOGY CENTER NNOC 56 INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY BDDD 60 CENTER FOR SYNTHESIS AND ANALYSIS S&A

2 GUIDE Annual Publication Report

3 GRONINGEN INSTITUTE FOR KIDNEY DISEASES - GIKD Dissertations Borggreve, S. E. The role of CETP and HDL metabolism in cardiac disease. (2008) Wolffenbuttel, B. H. R., de Jong, P. E., Hillege, J. L., and Dullaert, R. P. F. Bosma, R. J. Role of renal hemodynamics in obesity associated renal risk. (2008) Navis, G. J., de Jong, P. E., and Homan van der Heide, J. J. Brantsma, A. H. Course and consequeces of high urinary albumin excretion. (2008) de Jong, P. E., Zeeuw, D. de, Gansevoort, R. T., and Bakker, S. J. L. Hamming, I. Novel insights in the pathogenesis of renal interstitial damage during ACE inhibition : a role for ACE2 and the (pro)renin-receptor? (2008) Navis, G. J. and Goor, H. van Hartog, J. W. L. Advanced glycation end-products in cardiac and renal failure. (2008) Veldhuisen, D. J. van, Smit, A. J., Voors, A. A., and Bakker, S. J. L. Hettema, M. E. Micro- and macrovascular abnormalities in systemic sclerosis. (2008) Kallenberg, C. G. M., Bootsma, H., and Smit, A. J. Lambers Heerspink, H. J. Perspectives on randomized clinical trials : the case for albuminuria. (2008) Zeeuw, D. de and Gansevoort, R. T. Leeuw, K. de. Premature atherosclerosis in systemic autoimmune diseases. (2008) Kallenberg, C. G. M., Bijl, M., and Smit, A. J. Lutgers, H. L. Skin autofluorescence in diabetes mellitus. (2008) Gans, R. O. B., Bilo, H. J. G., Smit, A. J., Graaff, R., and Links, T. P. Oterdoom, L. H. Insulin resistance, renal dysfunction and cardiovascular disease, studies in a high and a low risk population. (2008) Gans, R. O. B., de Jong, P. E., Bakker, S. J. L., and Gansevoort, R. T. Timmeren, M. M. van. The proximal tubular cell, a key player in renal damage. (2008) Gans, R. O. B., Goor, H. van, Bakker, S. J. L., and Stegeman, C. A. Visser, F. W. Monitoring extra cellular fluid volume during renal function measurement. (2008) Navis, G. J. and Muntinga, J. H. J. Vogt, L. Strategies to optimize renoprotective therapy in proteinuric renal patients. (2008) Navis, G. J., Zeeuw, D. de, Dullaert, R. P. F., and Woittiez, A. J. J. Waanders, F. Advancements in renal protection. (2008) Navis, G. J. and Goor, H. van Journal Articles Abma, E. M., Kluin, P. M., Dullaart, R. P. F. Malignant aldosteroneproducing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism. Netherlands Journal of Medicine 66(6): , Asselbergs, F. W., van der Harst, P., van Roon, A. M., Hillege, H. L., de Jong, P. E., Gans, R. O. B., Smit, A. J., van Gilst, W. H. Longterm effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects. Atherosclerosis 196(1): , Asselbergs, F. W., van den Berg, M. P., Bakker, S. J., Signorovitch, J. E., Hillege, H. L., van Gilst, W. H., van Veldhuisen, D. J. N-terminal pro B-type natriuretic peptide levels predict newly detected atrial fibrillation in a population-based cohort. Netherlands Heart Journal 16(3): 73-78, Bakker S.J.L., Alkhalaf A., Tarnow L., Navis G. Comment on: wanic et al. (2008) exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in Type 1 Diabetes: Results of large case-control and follow-up studies. Diabetes 57: , Bakker, S. J. L., Gans, R. O. B., Navis, G. Dietary alkalinization and darusentan for prevention of decline in glomerular filtration rate in rats fed a casein diet. Kidney International 74(12): , Bello, A. K., Peters, J., Wight, J., de Zeeuw, D., El Nahas, M. A population-based screening for microalbuminuria among relatives of CKD patients: The Kidney Evaluation and Awareness Program in Sheffield (KEAPS). American Journal of Kidney Diseases 52(3): , Boersma, C., Postma, M. J., Visser, S. T., Atthobari, J., de Jong, P. E., den Berg, L. T. W. D., Gansevoort, R. T. Baseline albuminuria predicts the efficacy of blood pressure-lowering drugs in preventing cardiovascular events. British Journal of Clinical Pharmacology 65(5): , Borggreve, S. E., de Vries, R., linga-thie, G. M., Wolffenbuttel, B. H. R., Groen, A. K., van Tol, A., Dullaart, R. P. F. The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the- 629C -> A cholesteryl ester transfer protein promoter polymorphism: Role of Lecithin : Cholesterol acyltransferase activity. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1781(1-2): 10-15, Brantsma, A. H., Bakker, S. J. L., Hillege, H. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion. Nephrology Dialysis Transplantation 23(12): , Brantsma, A. H., Bakker, S. J. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Extended prognostic value of urinary albumin excretion for cardiovascular events. Journal of the American Society of Nephrology 19(9): , GUIDE Annual Publication Report

4 Brundel, B. J. J. M., Ke, L., Dijkhuis, A. J., Qi, X. Y., Shiroshita- Takeshita, A., Nattel, S., Henning, R. H., Kampinga, H. H. Heat shock proteins as molecular targets for intervention in atrial fibrillation. Cardiovascular Research 78(3): , Celie, J. W. A. M., Reijmers, R. M., Slot, E. M., Beelen, R. H. J., Spaargaren, M., ter Wee, P. M., Florquin, S., van den Born, J. Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria. American Journal of Physiology-Renal Physiology 294(1): F253-F263, Damman, K., van Veldhuisen, D. J., Navis, G., Voors, A. A., Hillege, H. L. Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure. European Journal of Heart Failure 10(10): , de Jong, P. E., Gansevoort, R. T. CKD - fiction not fact - Reply. Nephrology Dialysis Transplantation 23(8): , de Jong, P. E., Gansevoort, R. T. Fact or fiction of the epidemic of chronic kidney disease - let us not squabble about estimated GFR only, but also focus on albuminuria. Nephrology Dialysis Transplantation 23(4): , de Jong, P. E., Navis, G. Proteinuria lowering needs a multifactorial and individualized approach to halt progression of renal disease. Nature Clinical Practice Nephrology 4(12): , de Jong, P. E., van der Velde, M., Gansevoort, R. T., Zoccali, C. Screening for chronic kidney disease: Where does Europe go? Clinical Journal of the American Society of Nephrology 3(2): , de Leeuw, K., Kusumanto, Y., Smit, A. J., Oomen, P., van der Hoeven, J. H., Mulder, N. H., Hospers, G. A. P. Skin capillary permeability in the diabetic foot with critical limb ischaemia: the effects of a phvegf165 gene product. Diabetic Medicine 25(10): , de Leeuw, K., Blaauw, J., Smit, A. J., Kallenberg, C. G., Bijl, M. Vascular responsiveness in the microcirculation of patients with systemic lupus erythematosus is not impaired. Lupus 17(11): , de Vries, R., Groen, A. K., Perton, F. G., linga-thie, G. M., van Wijland, M. J. A., Dikkeschei, L. D., Wolffenbuttel, B. H. R., van Tol, A., Dullaart, R. P. F. Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: Roles of pre beta-hdl, phospholipid transfer protein and cholesterol esterification. Atherosclerosis 196(2): , de Zeeuw, D., Raz, I. Albuminuria: A Great Risk Marker, but an Underestimated Target in Diabetes. Diabetes Care 31: S190- S193, de Zeeuw, D., Bakker, S. J. L. Does the metabolic syndrome add to the diagnosis and treatment of cardiovascular disease? Nature Clinical Practice Cardiovascular Medicine 5(Suppl. 1): S10-S14, de Zeeuw, D. Renal disease: a common and a silent killer. Nature Clinical Practice Cardiovascular Medicine 5(Suppl. 1): S27-S35, de Zeeuw, D. Targeting proteinuria as a valid surrogate for individualized kidney protective therapy. American Journal of Kidney Diseases 51(5): , Doorenbos, C., Tsaih, S. W., Sheehan, S., Ishimori, N., Navis, G., Churchill, G., DiPetrillo, K., Korstanje, R. Quantitative trait loci for urinary albumin in crosses between C57BL/6J and A/J inbred mice in the presence and absenceof Apoe. Genetics 179(1): , Dullaart, R. P., Kobold, A. C. M., van Tol, A. Torcetrapib and coronary events. New England Journal of Medicine 358(17): 1863, Dullaart, R. P. F., Sluiter, W. J. Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis. Pharmacogenomics 9(6): , Dullaart, R. P. F., Groen, A. K., linga-thie, G. M., de Vries, R., Sluiter, W. J., van Tol, A. Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low highdensity lipoprotein cholesterol. European Journal of Endocrinology 158(1): 53-60, Dullaart, R. P. F., Schols, J. L., van der Steege, G., Zelissen, P. M. J., Sluiter, W. J., van Beek, A. P. Glucocorticoid replacement is associated with hypertriglyceridaemia, elevated glucose and higher non-hdl cholesterol and may diminish the association of HDL cholesterol with the-629c > A CETP promoter polymorphism in GH-receiving hypopituitary patients. Clinical Endocrinology 69(3): , Dullaart, R. P. F., de Vries, R., linga-thie, G. M., Sluiter, W. J., van Tol, A. Phospholipid transfer protein activity is determined by type 2 diabetes mellitus and metabolic syndrome, and is positively associated with serum transaminases. Clinical Endocrinology 68(3): , Dullaart, R. P. F., Perton, F., Sluiter, W. J., de Vries, R., van Tol, A. Plasma Lecithin: Cholesterol Acyltransferase Activity Is Elevated in Metabolic Syndrome and Is an Independent Marker of Increased Carotid Artery Intima Media Thickness. Journal of Clinical Endocrinology & Metabolism 93(12): , Dullaart, R. P. F., Borggreve, S. E., Hillege, H. L., linga-thie, G. M. The association of HDL cholesterol concentration with the-629c > A CETP promoter polymorphism is not fully explained by its relationship with plasma cholesteryl ester transfer. Scandinavian Journal of Clinical & Laboratory Investigation 68(2): , Geluk, C. A., Post, W. J., Hillege, H. L., Tio, R. A., Tijssen, J. G. P., van Dijk, R. B., Dijk, W. A., Bakker, S. J. L., de Jong, P. E., van Gilst, W. H., Zijlstra, F. C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: Data from the prospective PREVEND cohort. Atherosclerosis 196(1): , GUIDE Annual Publication Report

5 Gerrits, E. G., Lutgers, H. L., Kleefstra, N., Graaff, R., Groenier, K. H., Smit, A. J., Gans, R. O., Bilo, H. J. Skin autofluorescence - A tool to identify type 2 diabetic patients at risk for developing microvascular complications. Diabetes Care 31(3): , Groenewegen, H. C., van der Harst, P., Roks, A. J. M., Buikema, H., Zijlstra, F., van Gilst, W. H., de Smet, B. J. G. L. Effects of angiotensin II and angiotensin II type 1 receptor blockade on neointimal formation after stent implantation. International Journal of Cardiology 126(2): , Halbesma, N., Brantsma, A. H., Bakker, S. J. L., Jansen, D. F., Stolk, R. P., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Gender differences in predictors of the decline of renal function in the general population. Kidney International 74(4): , Hamming, I., van Goor, H., Turner, A. J., Rushworth, C. A., Michaud, A. A., Corvol, P., Navis, G. Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats. Experimental Physiology 93(5): , Hartog, J. W. L., Hummel, Y. M., Voors, A. A., Schalkwijk, C. G., Miyata, T., Huisman, R. M., Smit, A. J., van Veldhuisen, D. J. Skinautofluorescence, a measure of tissue advanced glycation endproducts (AGEs), is related to diastolic function in dialysis patients. Journal of Cardiac Failure 14(7): , Heerspink, H. J. L., Brantsma, A. H., de Zeeuw, D., Bakker, S. J. L., de Jong, P. E., Gansevoort, R. T. Albuminuria Assessed From First- Morning-Void Urine Samples Versus 24-Hour Urine Collections as a Predictor of Cardiovascular Morbidity and Mortality. American Journal of Epidemiology 168(8): , Heerspink, H. J. L., Dobre, D., Hillege, H. L., Grobbee, D. E., de Zeeuw, D. Does the European Clinical Trials Directive really improve clinical trial approval time? British Journal of Clinical Pharmacology 66(4): , Heerspink, H. J. L., Knol, M. J., Tijssen, R. J. W., van Leeuwen, T. N., Grobbee, D. E., de Zeeuw, D. Is the randomized controlled drug trial in Europe lagging behind the USA? British Journal of Clinical Pharmacology 66(6): , Heerspink, H. J. L., Witte, E. C., Bakker, S. J. L., de Jong, P. E., de Zeeuw, D., Gansevoort, R. T. Screening and monitoring for albuminuria: the performance of the HemoCue point-of-care system. Kidney International 74(3): , Hettema, M. E., Zhang, D., Stienstra, Y., Oomen, P. N. H., Smit, A. J., Kallenberg, C. G. M., Bootsma, H. Decreased capillary permeability and capillary density in patients with systemic sclerosis using large-window sodium fluorescein videodensitometry of the ankle. Rheumatology 47(9): , Hettema, M. E., Zhang, D., de Leeuw, K., Stienstra, Y., Smit, A. J., Kallenberg, C. G. M., Bootsma, H. Early atherosclerosis in systemic sclerosis and its relation to disease or traditional risk factors. Arthritis Research & Therapy 10(2 AR R49 DI /ar2408) Lusuf, D., Henning, R. H., van Gilst, W. H., Roks, A. J. M. Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives. European Journal of Pharmacology 585(2-3): , Ke, L., Qi, X. Y., Dijkhuis, A. J., Chartier, D., Nattel, S., Henning, R. H., Kampinga, H. H., Brundel, B. J. M. Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. Journal of Molecular and Cellular Cardiology 45(5): , Krebs, C., Weber, M., Steinmetz, O., Meyer-Schwesinger, C., Stahl, R., Danser, A. H. J., Garrelds, I., van Goor, H., Nguyen, G., Muller, D., Wenzel, U. Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats. Kidney International 74(6): , Krikken, J. A., linga-thie, G. M., Navis, G., Dullaart, R. P. F. Reninangiotensin-aldosterone responsiveness to low sodium and blood pressure reactivity to angiotensin-ii are unrelated to cholesteryl ester transfer protein mass in healthy subjects. Expert Opinion on Therapeutic Targets 12(11): , Kuipers, I., van der Harst, P., Navis, G., van Genne, L., Morello, F., van Gilst, W. H., van Veldhuisen, D. J., de Boer, R. A. Nuclear hormone receptors as regulators of the renin-angiotensinaldosterone system. Hypertension 51(6): , Langeveld, B. E., Henning, R. H., de Smet, B. J. G. L., Zijlstra, F., Driessen, A., Tijsma, E., van Gilst, W. H., Roks, A. J. M. Rescue of arterial function by angiotensin(1-7): towards improvement of endothelial function by drug-eluting stents. Netherlands Heart Journal 16(9): , Lely, A. T., van der Kleij, F. G. H., Kistemaker, T. J., Apperloo, A. J., de Jong, P. E., de Zeeuw, D., Navis, G. Impact of the preintervention rate of renal function decline on outcome of renoprotective intervention. Clinical Journal of the American Society of Nephrology 3(1): 54-60, Lijfering, W. M., de Vries, A. R. J., Veeger, N. J. G. M., van Son, W. J., Bakker, S. J. L., van der Meer, J. Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation. Thrombosis and Haemostasis 99(1): , Liu, Y., van Goor, H., Havinga, R., Baller, J. F. W., Bloks, V. W., van der Leij, F. R., Sauer, P. J. J., Kuipers, F., Navis, G., de Borst, M. H. Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response. American Journal of Physiology-Renal Physiology 294(4): F768-F776, Loef, B. G., Henning, R. H., Navis, G., Rankin, A. J., van Oeveren, W., Ebels, T., Epema, A. H. Changes in glomerular filtration rate after cardiac surgery with cardiopulmonary bypass in patients with mild preoperative renal dysfunction. British Journal of Anaesthesia 100(6): , Maathuis, M. H. J., Ottens, P. J., van Goor, H., Zwaagstra, J. J., Wiersema-Buist, J., Schuurs, T. A., Ploeg, R. J., Leuvenink, H. G. D. Static cold storage preservation of ischemically damaged GUIDE Annual Publication Report

6 kidneys. A comparison between IGL-1 and UW solution. Transplant International 21(5): , Mahmoodi, B. K., Ten Kate, M. K., Waanders, F., Veeger, N. J. G. M., Brouwer, J. L. P., Vogt, L., Navis, G., van der Meer, J. High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome. Circulation 117(2): , Meerwaldt, R., van der Vaart, M. G., van Dam, G. M., Tio, R. A., Hillebrands, J. L., Smit, A. J., Zeebregts, C. J. Clinical relevance of advanced glycation endproducts for vascular surgery. European Journal of Vascular and Endovascular Surgery 36(2): , Meerwaldt, R., Links, T., Zeebregts, C., Smit, A. Re: "Plasma fluorescent oxidation products as potential markers of oxidative stress for epidemiologic studies". American Journal of Epidemiology 167(6): , Meerwaldt, R., Links, T., Zeebregts, C., Tio, R., Hillebrands, J. L., Smit, A. The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes. Cardiovascular Diabetology 7 AR 29 DI / : 29, Meeuwisse-Pasterkamp, S. H., Van Der Klauw, M. M., Wolffenbuttel, B. H. Type 2 diabetes mellitus: prevention of macrovascular complications. Expert Review of Cardiovascular Therapy 6(3): , Meijer, E., de Jong, P. E., Peters, D. J., Gansevoort, R. T. Better understanding of ADPKD results in potential new treatment options: ready for the cure? Journal of Nephrology 21(2): , Melenhorst, W. B. W. H., Mulder, G. M., Xi, Q., Hoenderop, J. G. J., Kimura, K., Eguchi, S., van Goor, H. Epidermal Growth Factor Receptor Signaling in the Kidney Key Roles in Physiology and Disease. Hypertension 52(6): , Mulder, D. J., van Haelst, P. L., Gross, S., de Leeuw, K., Bijzet, J., Graaff, R., Gans, R. O., Zijlstra, F., Smit, A. J. Skin autofluorescence is elevated in patients with stable coronary artery disease and is associated with serum levels of neopterin and the soluble receptor for advanced glycation end products. Atherosclerosis 197(1): , Nienhuis, H. L., de Leeuw, K., Bijzet, J., Smit, A., Schalkwijk, C. G., Graaff, R., Kallenberg, C. G., Bijl, M. Skin autofluorescence is increased in systemic lupus erythematosus but is not reflected by elevated plasma levels of advanced glycation endproducts. Rheumatology 47(10): , Noordzij, M. J., Lefrandt, J. D., Smit, A. J. Advanced glycation end products in renal failure: an overview. Journal of Renal Care 34(4): , Onuta, G., Hillebrands, J. L., Rienstra, H., Boer, M. W., Klatter, F. A., Navis, G., Rozing, J., Roks, A. J. M. Dichotomous effects of rosiglitazone in transplantation-induced systemic vasodilator dysfunction in rats. Transplantation 85(4): , Oterdoom, L. H., van Ree, R. M., de Vries, A. P. J., Gansevoort, R. T., Schouten, J. P., van Son, W. J., van der Heide, J. J. H., Navis, G., de Jong, P. E., Gans, R. O. B., Bakker, S. J. L. Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients. Transplantation 86(3): , Parving, H. H., de Zeeuw, D., Cooper, M. E., Remuzzi, G., Liu, N., Lunceford, J., Shahinfar, S., Wong, P. H., Lyle, P. A., Rossing, P., Brenner, B. M. ACE gene polymorphism and losartan treatment in type 2 diabetic patients with nephropathy. Journal of the American Society of Nephrology 19(4): , Penning-van Beest, F. J. A., Wolffenbuttel, B. H. R., Herings, R. M. C. Haemoglobin A(1c) goal attainment in relation to dose in patients with diabetes mellitus taking metformin. Clinical Drug Investigation 28(8): , Postma, M. J., Boersma, C., Gansevoort, R. T. Pharmacoeconomics in nephrology: considerations on cost-effectiveness of screening for albuminuria. Nephrology Dialysis Transplantation 23(4): , Prakash, J., de Borst, M. H., van Loenen-Weemaes, A. M., Lacombe, M., Opdam, F., van Goor, H., Meijer, D. K. F., Moolenaar, F., Poelstra, K., Kok, R. J. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. Pharmaceutical Research 25(10): , Prakash, J., de Borst, M. H., Lacombe, M., Opdam, F., Klok, P. A., van Goor, H., Meijer, D. K. F., Moolenaar, F., Poelstra, K., Kok, R. J. Inhibition of Renal Rho Kinase Attenuates Ischemia/Reperfusion- Induced Injury. Journal of the American Society of Nephrology 19(11): , Prakash, J., Poelstra, K., van Goor, H., Moolenaar, F., Meijer, D. K. F., Kok, R. J. Novel therapeutic targets for the treatment of tubulointerstitial fibrosis. Current Signal Transduction Therapy 3(2): , Ricardo, S. D., van Goor, H., Eddy, A. A. Macrophage diversity in renal injury and repair. Journal of Clinical Investigation 118(11): , Rook, M., Bosma, R. J., van Son, W. J., Hofker, H. S., van der Heide, J. J. H., ter Wee, P. M., Ploeg, R. J., Navis, G. J. Nephrectomy elicits impact of age and BMI on renal hemodynamics: Lower postdonation reserve capacity in older or overweight kidney donors. American Journal of Transplantation 8(10): , Sandovici, M., Deelman, L. E., de Zeeuw, D., van Goor, H., Henning, R. H. Immune modulation and graft protection by gene therapy in kidney transplantation. European Journal of Pharmacology 585(2-3): , Sandovici, M., Henning, R. H., van Goor, H., Helfrich, W., de Zeeuw, D., Deelman, L. E. Systemic gene therapy with interleukin-13 attenuates renal ischemia-reperfusion injury. Kidney International 73(12): , GUIDE Annual Publication Report

7 Sluimer, J. C., Gasc, J. M., Hamming, I., van Goor, H., Michaud, A., Visser, F. W., Muntinga, J. H. J., Dierckx, R. A., Navis, G. Feasibility van den Akker, L. H., Jutten, B., Cleutjens, J., Bijnens, A. P. J. J., and impact of the measurement of extracellular fluid volume Corvol, P., Daemen, M. J. A. P., Heeneman, S. Angiotensinconverting enzyme 2 (ACE2) expression and activity in human the American Society of Nephrology 3(5): , simultaneous with GFR by I-125-iothalamate. Clinical Journal of carotid atherosclerotic lesions. Journal of Pathology 215(3): , Visser, F. W., Boonstra, A. H., Lely, A. T., Boomsma, F., Navis, G. Stolk, R. P., Rosmalen, J. G. M., Postma, D. S., de Boer, R. A., Navis, G., Slaets, J. P. J., Ormel, J., Wolffenbuttel, B. H. R. Universal risk factors for multifactorial diseases - LifeLines: a three-generation population-based study. European Journal of Epidemiology 23(1): 67-74, Thompson, A., Di Angelantonio, E., Sarwar, N., Erqou, S., Saleheen, D., Dullaart, R. P. F., Keavney, B., Ye, Z., Danesh, J. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. Journal of the American Medical Association 299(23): , Trzpis, M., McLaughlin, P. M., van Goor, H., Brinker, M. G. L., van Dam, G. M., de Leij, L. M., Popa, E. R., Harmsen, M. C. Expression of EpCAM is up-regulated during regeneration of renal epithelia. Journal of Pathology 216(2): , Turnbull, F., Woodward, M., Neal, B., Barzi, F., Ninomiya, T., Chalmers, J., Perkovic, V., Li, N., MacMahon, S. Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. European Heart Journal 29(21): , Ulu, N., Buikema, H., van Gilst, W. H., Navis, G. Vascular dysfunction in adriamycin nephrosis: different effects of adriamycin exposure and nephrosis. Nephrology Dialysis Transplantation 23(6): , Renal response to angiotensin II is blunted in sodium-sensitive normotensive men. American Journal of Hypertension 21(3): , Vogt, L., Waanders, F., Boornsma, F., de Zeeuw, D., Navis, G. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. Journal of the American Society of Nephrology 19(5): , Voorham, J., Denig, P., Wolffenbuttel, B. H. R., Haaijer-Ruskamp, F. M. Cross-sectional versus sequential quality indicators of risk factor management in patients with type 2 diabetes. Medical Care 46(2): , Voorham, J., Haaijer-Rustcamp, F. M., Stolk, R. P., Wolffenbuttel, B. H. R., Denig, P. Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes. Diabetes Care 31(3): , Waanders, F., van Goor, H., Navis, G. Adverse Renal Effects of the AGE Inhibitor Pyridoxamine in Combination with ACEi in Non- Diabetic Adriamycin-Induced Renal Damage in Rats. Kidney & Blood Pressure Research 31(5): , Waanders, F., van den Berg, E., Nagai, R., van Veen, I., Navis, G., van Goor, H. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats. Nephrology Dialysis Transplantation 23(2): , Windt, W. A. K. M., Henning, R. H., Kluppel, A. C. A., Xu, Y., de Zeeuw, D., van Dokkum, R. P. E. Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats. Nephrology Dialysis Transplantation 23(10): , van der Harst, P., Groenewegen, H. C., Roks, A. J. M., Buikema, H., Zijlstra, F., van Gilst, W. H., de Smet, B. J. G. L. Rosuvastatin attenuates angiotensin II-induced neointimal formation after stent implantation in the rat. Coronary Artery Disease 19(1): 47-53, Windt, W. A. K. M., van Dokkuni, R. P. E., Kluppel, C. A., Jeronimus- van Ree, R. M., Oterdoom, L. H., de Vries, A. P. J., van der Heide, J. J. H., van Son, W. J., Navis, G., Gans, R. O. B., Bakker, S. J. L. Circulating Markers of Endothelial Dysfunction Interact With Proteinuria in Predicting Mortality in Renal Transplant Recipients. Transplantation 86(12): , van Timmeren, M. M., Gross, M. L., Hanke, W., Klok, P. A., van Goor, H., Stegeman, C. A., Bakker, S. J. L. Oleic acid loading does not add to the nephrotoxic effect of albumin in an amphibian and chronic rat model of kidney injury. Nephrology Dialysis Transplantation 23(12): , Vegter, S., Boersma, C., Rozenbaum, M., Wilffert, B., Navis, G., Postma, M. J. Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes - A systematic review on content and adherence to guidelines. Pharmacoeconomics 26(7): , Vergeer, M., linga-thie, G. M., Dullaart, R. P. F., van Tol, A. Evaluation of phospholipid transfer protein as a therapeutic target. Future Lipidology 3(3): , Stratingh, C. M., Hut, F., de Zeeuw, D., Henning, R. H. Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats. European Journal of Pharmacology 580(1-2): , Xu, Y., Bulikema, H., van Gilst, W. H., Henning, R. H. Caveolae and endothelial dysfunction: Filling the caves in cardiovascular disease. European Journal of Pharmacology 585(2-3): , GUIDE Annual Publication Report

8 CARDIOVASCULAR CENTER CVC Dissertations Borggreve, S. E. The role of CETP and HDL metabolism in cardiac disease. (2008) Wolffenbuttel, B. H. R., de Jong, P. E., Hillege, J. L., and Dullaert, R. P. F. Dieperink, W. Multiple applications of the Boussignac continuous positive airway pressure system. (2008) Dieperink, W., Aarts, L. P. H. J., Zijlstra, F., Nijsten, M. W. N., and Jaarsma, T. Geluk, C. A. Coronary risk stratification : from PREVEND to the prevention of coronary events. (2008) Zijlstra, F., Gilst, W. H. van, and Hillege, J. L. Groenewegen, H. C. Therapeutic and mechanistic explorations of in-stent restenosis in the rat aortic stenting model. (2008) Zijlstra, F. and Gilst, W. H. van Hartog, J. W. L. Advanced glycation end-products in cardiac and renal failure. (2008) Veldhuisen, D. J. van, Smit, A. J., Voors, A. A., and Bakker, S. J. L. Nienhuis, M. B. Prognostic implications of myocardial injury around percutaneous coronary interventions. (2008) Zijlstra, F., Bilo, H. J. G., and Ottervanger, J. P. Qian, C. The effect of angiotensin (1-7) on bone marrow stem cells : adjunctive pharmacological therapy for cell transplantation in heart failure. (2008) Gilst, W. H. van, Roks, A. J. M., and Schoemaker, R. G. Smit, J. J. J. Platelets and white blood cells in acute coronary syndromes. (2008) Zijlstra, F., Hof, A. W. J. van 't, and Ottervanger, J. P. Tan, E. S. Advanced clinical approaches in complex cardiovascular disease : invasive options at the crossroad of ischemia, heart failure, and arrhythmias. (2008) Gelder, I. C. van, Zijlstra, F., and Jessurun, G. A. J. van Tintelen, J. P. Inherited cardiomyopathies. (2008) Hofstra, R. M. W., Veldhuisen, D. J. van, and van den Berg, M. P. Vogelzang, M. Computer assisted decision support in acutely ill patients. Application in glucose management and quantification of myocardial reperfusion. (2008) Zijlstra, F. and Nijsten, M. W. N. Westenbrink, B. D. Erythropoietin in heart failure : pathology and protection. (2008) Veldhuisen, D. J. van, Gilst, W. H. van, Voors, A. A., and Schoenmaker, R. G. Journal Articles Aalberts, J. J. J., Waterbolk, T. W., van Tintelen, J. P., Hillege, H. L., Boonstra, P. W., van den Berg, M. P. Prophylactic aortic root surgery in patients with Marfan syndrome: 10 years' experience with a protocol based on body surface area. European Journal of Cardio-Thoracic Surgery 34(3): , Aalberts, J. J. J., van den Berg, M. P., Bergman, J. E. H., Sarvaas, G. J. D., Post, J. G., van Unen, H., Pals, G., Boonstra, P. W., van Tintelen, J. P. The many faces of aggressive aortic pathology: Loeys-Dietz syndrome. Netherlands Heart Journal 16(9): , Ahmed, S., Rienstra, M., Crijns, H. J. G. M., Links, T. P., Wiesfeld, A. C. P., Hillege, H. L., Bosker, H. A., Lok, D. J. A., van Veldhuisen, D. J., van Gelder, I. C. Continuous vs episodic prophylactic treatment with amiodarone for the prevention of atrial fibrillation - A randomized trial. Journal of the American Medical Association 300(15): , Asselbergs, F. W., Pattin, K., Snieder, H., Hillege, H. L., van Gilst, W. H., Moore, J. H. Genetic Architecture of Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor- 1. Seminars in Thrombosis and Hemostasis 34(6): , Asselbergs, F. W., van der Harst, P., van Roon, A. M., Hillege, H. L., de Jong, P. E., Gans, R. O. B., Smit, A. J., van Gilst, W. H. Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects. Atherosclerosis 196(1): , Asselbergs, F. W., van den Berg, M. P., Bakker, S. J., Signorovitch, J. E., Hillege, H. L., van Gilst, W. H., van Veldhuisen, D. J. N-terminal pro B-type natriuretic peptide levels predict newly detected atrial fibrillation in a population-based cohort. Netherlands Heart Journal 16(3): 73-78, Barents, M., Hillege, H. H. L., van der Horst, I. C. C., de Boer, R. A., Koster, J., Muskiet, F. A. J., de Jongste, M. J. L. BNP and NTproBNP, Predictors of 1-Year Mortality in Nursing Home Residents. Journal of the American Medical Directors Association 9(8): , Barents, M., van der Horst, I. C. C., Voors, A. A., Hillege, J. L., Muskiet, F. A. J., de Jongste, M. J. L. Prevalence and misdiagnosis of chronic heart failure in nursing home residents: the role of B-type natriuretic peptides. Netherlands Heart Journal 16(4): , Belonje, A. M., Voors, A. A., van Gilst, W. H., Anker, S. D., Slart, R. H., Tio, R. A., Zijlstra, F., van Veldhuisen, D. J. Effects of erythropoietin after an acute myocardial infarction: Rationale and study design of a prospective, randomized, clinical trial (HEBE III). American Heart Journal 155(5): , Belonje, A. M. S., de Boer, R. A., Voors, A. A. Recombinant human epo treatment: Beneficial in chronic kidney disease, chronic heart failure, or both? Cardiovascular Drugs and Therapy 22(1): 1-2,

9 Berger, R. M. F., Pricker, K., Hoendermis, E. S., Bartelds, B. Percutaneous atrial septal defect closure in patients with pulmonary hypertension. Heart 94(12): 1653, Boersma, C., Voors, A. A., Postma, M. J. Losartan is cost-effective in the treatment of hypertension in patients with left ventricular hypertrophy. Pharmaceutisch Weekblad 143(7): 32-36, Boersma, C., Voors, A. A., Postma, M. J. Losartan is kosteneffectief in de behandeling van hypertensie bij patiënten met linkerventrikelhypertrofie. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(2): 32-36, Brantsma, A. H., Bakker, S. J. L., Hillege, H. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion. Nephrology Dialysis Transplantation 23(12): , Braunschweig, F., Ford, I., Conraads, V., Cowie, M. R., Jondeau, G., Kautzner, J., Lunati, M., Aguilera, R. M., Yu, C. M., Marijianowskii, M., Borggrefe, M., van Veldhuisen, D. J. Can monitoring of intrathoracic impedance reduce morbidity and mortality in patients with chronic heart failure? Rationale and design of the Diagnostic Outcome Trial in Heart Failure (DOT-HF). European Journal of Heart Failure 10(9): , Brouilette, S. W., Whittaker, A., Stevens, S. E., van der Harst, P., Goodall, A. H., Samani, N. J. Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis. Heart 94(4): , Buck, S., Rienstra, M., Maass, A. H., Nieuwland, W., van Veldhuisen, D. J., van Gelder, I. C. Cardiac resynchronization therapy in patients with heart failure and atrial fibrillation: importance of new-onset atrial fibrillation and total atrial conduction time. Europace 10(5): , Buck, S., Maass, A. H., van Gelder, I. C. How to prevent ICD shocks: part I. Europace 10(9): , Buck, S., Maass, A. H., van Gelder, I. C. How to prevent ICD shocks: part II. Europace 10(9): , Buck, S., Maass, A. H., Nieuwland, W., Anthonio, R. L., van Veldhuisen, D. J., van Gelder, I. C. Impact of interventricular lead distance and the decrease in septal-to-lateral delay on response to cardiac resynchronization therapy. Europace 10(11): , Chocron, S., Baillot, R., Rouleau, J. L., Warnica, W. J., Block, P., Johnstone, D., Myers, M. G., Calciu, C. D., Nozza, A., Martineau, P., van Gilst, W. H. Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study. European Heart Journal 29(5): , Cox, M. G. P. J., Nelen, M. R., Wilde, A. A. M., Wiesfeld, A. C., van der Smagt, J., Loh, P., Cramer, M. J., Doevendans, P. A., van Tintelen, J. P., De Bakker, J. M. T., Hauer, R. N. W. Activation delay and VT parameters in arrhythmogenic right ventricular dysplasia/cardiomyopathy: Toward improvement of diagnostic ECG criteria. Journal of Cardiovascular Electrophysiology 19(8): , Dalageorgou, C., Ge, D., Jamshidi, Y., Nolte, I. M., Riese, H., Savelieva, I., Carter, N. D., Spector, T. D., Snieder, H. Heritability of QT interval: How much is explained by genes for resting heart rate? Journal of Cardiovascular Electrophysiology 19(4): , Damman, K., de Boer, R. A., van Veldhuisen, D. J. Heart failure, aging and beta-blockers: the need for more data on tolerability and efficacy. Clinical Research in Cardiology 97(9): , Damman, K., van Veldhuisen, D. J., Navis, G., Voors, A. A., Hillege, H. L. Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure. European Journal of Heart Failure 10(10): , de Boer, R. A., van Veldhuisen, D. J. ACE-inhibitors, beta-blockers or the combination in heart failure: Is it just an A-B-C? Cardiovascular Drugs and Therapy 22(4): , de Boer, R. A., van Veldhuisen, D. J. Letter by de Boer and van Veldhuisen regarding article, "Risk of Thromboembolism in Heart Failure: An Analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)". Circulation 117(1): E7, de Jonge, G. J., van Ooijen, P. M. A., Piers, L. H., Dikkers, R., Tio, R. A., Willems, T. P., van den Heuvel, A. F. M., Zijlstra, F., Oudkerk, M. Visualization of anomalous coronary arteries on dual-source computed tomography. European Radiology 18(11): , de Luca, G., Dudek, D., Sardella, G., Marino, P., Chevalier, B., Zijlstra, F. Adjunctive manual thrombectomy improves myocardial perfusion and mortality in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: a meta-analysis of randomized trials. European Heart Journal 29(24): , De Luca, L., Mebazaa, A., Filippatos, G., Parissis, J. T., Bohm, M., Voors, A. A., Nieminen, M., Zannad, F., Rhodes, A., El-Banayosy, A., Dickstein, K., Gheorghiade, M. Overview of emerging pharmacologic agents for acute heart failure syndromes. European Journal of Heart Failure 10(2): , De Smedt, R. H. E., Jaarsma, T., van den Broek, S. A. J., Haaijer- Ruskamp, F. M. Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. British Journal of Clinical Pharmacology 66(2): , de Vos, A. M., Rutten, A., De Zaag-Loonen, H. J. V., Bots, M. L., Dikkers, R., Buiskool, R. A., Mali, W. P., Lubbers, D. D., Mosterd, A., Prokop, M., Rensing, B. J., Cramer, M. J., van Es, H. W., Moll, F. L., de Pavoordt, E. D. V., Doevendans, P. A., Velthuis, B. K., Mackaay, A. J., Zijlstra, F., Oudkerk, M. Non-invasive cardiac assessment in high risk patients (The GROUND study): rationale, objectives and design of a multi-center randomized controlled clinical trial. Trials 9 AR 49 DI / GUIDE Annual Publication Report

10 de Vries, B. M. W., van Dam, G. M., Tio, R. A., Hillebrands, J. L., Slart, R. H. J. A., Zeebregts, C. J. Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque. Journal of Vascular Surgery 48(6): , Deuling, J. H. H., Jaarsma, T., Vermeulen, R. P., van den Heuvel, A. F. M. A randomized controlled trial comparing StarClose and AngioSeal vascular closure devices in a district general hospital. International Journal of Clinical Practice 62(11): 1801, Deuling, J. H. H., Vermeulen, R. P., Anthonio, R. A., van den Heuvel, A. F. M., Jaarsma, T., Jessurun, G., de Smet, B. J. G. L., Tan, E. S., Zijistra, F. Closure of the femoral artery after cardiac catheterization: A comparison of Angio-Seal, StarClose, and manual compression. Catheterization and Cardiovascular Interventions 71(4): , Dieperink, W., Nijsten, M. W. N., van de Stadt, M., van der Horst, I. C. C., Aarts, L. P. H. J., Zijlstra, F., Jaarsma, T. Implementation of Boussignac continuous positive airway pressure in the coronary care unit: Experiences and attitudes. Heart & Lung 37(6): , Dikkers, R., Willems, T. P., Piers, L. H., de Jonge, G. J., Tio, R. A., van der Zaag-Loonen, H. J., van Ooijen, P. M. A., Zijlstra, F., Oudkerk, M. Coronary revascularization treatment based on dual-source computed tomography. European Radiology 18(9): , Dobre, D., van Veldhuisen, D. J., Goulder, M. A., Krum, H., Willenheimer, R. Clinical effects of initial 6 months monotherapy with bisoprolol versus enalapril in the treatment of patients with mild to moderate chronic heart failure. Data from the CIBIS III trial. Cardiovascular Drugs and Therapy 22(5): , Dobre, D., de Jongste, M. J. L., Haaijer-Ruskamp, F. M., Sanderman, R., van Veldhuisen, D. J., Ranehor, A. V. The enigma of quality of life in patients with heart failure. International Journal of Cardiology 125(3): , Drenthen, W., Pieper, P. G., van der Tuuk, K., Roos-Hesselink, J. W., Hoendermis, E. S., Voors, A. A., Mulder, B. J. M., van Dijk, A. P. J., Yap, S. C., Vliegen, H. W., Moons, P., Ebels, T., van Veldhuisen, D. J. Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle. Cardiology 109(2): , Drenthen, W., Hoendermis, E. S., Moons, P., Heida, K. Y., Roos- Hesselink, J. W., Mulder, B. J. M., van Dijk, A. P. J., Vliegen, H. W., Sollie, K. M., Berger, R. M. F., Lely, A. T., Canobbio, M. M., Pieper, P. G. Menstrual cycle and its disorders in women with congenital heart disease. Congenital Heart Disease 3(4): , Dullaart, R. P. F., Borggreve, S. E., Hillege, H. L., linga-thie, G. M. The association of HDL cholesterol concentration with the-629c > A CETP promoter polymorphism is not fully explained by its relationship with plasma cholesteryl ester transfer. Scandinavian Journal of Clinical & Laboratory Investigation 68(2): , El Baz, N., Middel, B., Van Dijk, J. R., Wesselman, D. C. M., Boonstra, P. W., Reijneveld, S. A. EuroSCORE predicts poor health-related physical functioning six month postcoronary artery bypass graft surgery. Journal of Cardiovascular Surgery 49(5): , Gatzoulis, M. A., Beghetti, M., Galie, N., Granton, J., Berger, R. M. F., Lauer, A., Chiossi, E., Landzberg, M. Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: Results of the BREATHE-5 open-label extension study. International Journal of Cardiology 127(1): 27-32, Geluk, C. A., Post, W. J., Hillege, H. L., Tio, R. A., Tijssen, J. G. P., van Dijk, R. B., Dijk, W. A., Bakker, S. J. L., de Jong, P. E., van Gilst, W. H., Zijlstra, F. C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: Data from the prospective PREVEND cohort. Atherosclerosis 196(1): , Geluk, C. A., Dikkers, R., Perik, P. J., Tio, R. A., Gotte, M. J. W., Hillege, H. L., Vliegenthart, R., Houwers, J. B., Willems, T. P., Oudkerk, M., Zijlstra, F. Measurement of coronary calcium scores by electron beam computed tomography or exercise testing as initial diagnostic tool in low-risk patients with suspected coronary artery disease. European Radiology 18(2): , Goyenechea, E., Collins, L. J., Parra, D., Liu, G. F., Snieder, H., Swaminathan, R., Spector, T. D., Martinez, J. A., O'Dell, S. D. CD36 Gene Promoter Polymorphisms Are Associated With Low Density Lipoprotein-Cholesterol in Normal Twins and After a Low-Calorie Diet in Obese Subjects. Twin Research and Human Genetics 11(6): , Groen, J. M., Greuter, M. J. W., Vliegenthart, R., Suess, C., Schmidt, B., Zijlstra, F., Oudkerk, M. Calcium scoring using 64-slice MDCT, dual source CT and EBT: a comparative phantom study. International Journal of Cardiovascular Imaging 24(5): , Groenewegen, H. C., van der Harst, P., Roks, A. J. M., Buikema, H., Zijlstra, F., van Gilst, W. H., de Smet, B. J. G. L. Effects of angiotensin II and angiotensin II type 1 receptor blockade on neointimal formation after stent implantation. International Journal of Cardiology 126(2): , Groenewegen, H. C., Onuta, G., Goris, M., Zandvoort, A., Zijlstra, F., van Gilst, W. H., Rozing, J., de Smet, B. J. G. L., Roks, A. J. M., Hillebrands, J. L. Non-Bone Marrow Origin of Neointimal Smooth Muscle Cells in Experimental In-Stent Restenosis in Rats. Journal of Vascular Research 45(6): , Groenveld, H. F., Januzzi, J. L., Damman, K., van Wijngaarden, J., Hillege, H. L., van Veldhuisen, D. J., van der Meer, P. Anemia and mortality in heart failure patients - A systematic review and meta-analysis. Journal of the American College of Cardiology 52(10): , Gu, Y. L., Fokkema, M. L., Zijlstra, F. The Emerging Role of Thrombus Aspiration in the Management of Acute Myocardial Infarction. Circulation 118(18): , Harsma, T., van Veldhuisen, D. J. When, how and where should we "coach" patients with heart failure: The COACH results in perspective. European Journal of Heart Failure 10(4): , GUIDE Annual Publication Report

11 Hartog, J. W. L., Hummel, Y. M., Voors, A. A., Schalkwijk, C. G., Miyata, T., Huisman, R. M., Smit, A. J., van Veldhuisen, D. J. Skinautofluorescence, a measure of tissue advanced glycation endproducts (AGEs), is related to diastolic function in dialysis patients. Journal of Cardiac Failure 14(7): , Hartog, J. W. L., Willemsen, S., Voors, A. A. What is the influence of renal function on the prognostic value of advanced glycation end-products and srage in heart failure? Journal of Cardiac Failure 14(7): 626, Hazenberg, A. J. C., Jessurun, G. A. J., Tio, R. A. Mechanisms involved in symptomatic myocardial bridging. Netherlands Heart Journal 16(1): 10-15, Heerspink, H. J. L., Dobre, D., Hillege, H. L., Grobbee, D. E., de Zeeuw, D. Does the European Clinical Trials Directive really improve clinical trial approval time? British Journal of Clinical Pharmacology 66(4): , Hemels, M. E. W., Ruiter, J. H., Molhoek, G. P., Veeger, N. J. G. M., Wiesfeld, A. C. P., Ranchor, A. V., van Trigt, M., Pilmeyer, A., van Gelder, I. C. Right atrial preventive and antitachycardia pacing for prevention of paroxysmal atrial fibrillation in patients without bradycardia: a randomized study. Europace 10(3): , Hendriks, K. S. W. H., Hendriks, M. M. W. B., Birnie, E., Grosfed, F. J. M., Wilde, A. A. M., van den Bout, J., Smets, E. M. A., van Tinteten, J. P., ten Kroode, H. F. J., van Langen, I. M. Familial disease with a risk of sudden death: A longitudinal study of the psychological consequences of predictive testing for long QT syndrome. Heart Rhythm 5(5): , Hirsch, A., Nijveldt, R., van der Vleuten, P. A., Tio, R. A., van der Giessen, W. J., Marques, K. M. J., Doevendans, P. A., Waltenberger, J., ten Berg, J. M., Aengevaeren, W. R. M., Biemond, B. J., Tijssen, J. G. P., van Rossum, A. C., Piek, J. J., Zijlstra, F. Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: Pilot study of the multicenter HEBE trial. Catheterization and Cardiovascular Interventions 71(3): , Hoekema, A., Voors, A. A., Wijkstra, P. J., Stegenga, B., van der Hoeven, J. H., Tol, C. G., de Bont, L. G. M. Effects of oral appliances and CPAP on the left ventricle and natriuretic peptides. International Journal of Cardiology 128(2): , Hoendermis, E. S., Drenthen, W., Sollie, K. M., Berger, R. M. F. Severe pregnancy-induced deterioration of truncal valve regurgitation in an adolescent patient with repaired truncus arteriosus. Cardiology 109(3): , Huzen, J., van Veldhuisen, D. J., van der Harst, P. Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System: The Framingham Heart Study. Circulation 118(19): E688, Huzen, J., van Veldhuisen, D. J., van Gilst, W. H., van der Harst, P. Telomeres and biological ageing in cardiovascular disease. Nederlands Tijdschrift voor Geneeskunde 152(22): , Lusuf, D., Henning, R. H., van Gilst, W. H., Roks, A. J. M. Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives. European Journal of Pharmacology 585(2-3): , Jaarsma, T., van der Wal, M. H. L., Lesman-Leegte, I., Luttik, M. L., Hogenhuis, J., Veeger, N. J., Sanderman, R., Hoes, A. W., van Gilst, W. H., Lok, D. J. A., Dunselman, P. H. J. M., Tijssen, J. G. P., Hillege, H. L., van Veldhuisen, D. J. Effect of moderate or intensive disease management program on outcome in patients with heart failure. Archives of Internal Medicine 168(3): , Jaarsma, T., Lesman, I., van Veldhuisen, D. J. Psychology and cardiology: do not forget the heart failure patient. European Heart Journal 29(9): 1208, Jaarsma, T. Secondary prevention of coronary heart disease and heart failure in primary care. Heart 94(9): 1211, Jaarsma, T., Lvan Der Wal, M. H., Lesman-Leegte, I., Luttik, M. L., Hogenhuis, J., Veeger, N. J., Sanderman, R., Hoes, A. W., van Gilst, W. H., Lok, D. J. A., Dunselman, P. H. J. M., Tijssen, J. G. P., Hillege, H. L., van Veldhuisen, D. J. Value of basic or intensive management of patients with heart failure confirmed in a randomised controlled clinical trial. Nederlands Tijdschrift voor Geneeskunde 152(37): , Kapuku, G. K., Ge, D. L., Vemulapalli, S., Harshfield, G. A., Treiber, F. A., Snieder, H. Change of genetic determinants of left ventricular structure in adolescence: Longitudinal evidence from the Georgia Cardiovascular Twin Study. American Journal of Hypertension 21(7): , Kindermann, M., Reil, J. C., Pieske, B., van Veldhuisen, D. J., Bohm, M. Heart Failure With Normal Left Ventricular Ejection Fraction: What is the Evidence? Trends in Cardiovascular Medicine 18(8): , Kuipers, I., van der Harst, P., Navis, G., van Genne, L., Morello, F., van Gilst, W. H., van Veldhuisen, D. J., de Boer, R. A. 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J., Svilaas, T., Vogelzang, M., Diercks, G. F., de Smet, B. J., van den Heuvel, A. F., Anthonio, R. L., Jessurun, G. A., Tan, E., Suurmeijer, A. J., Zijlstra, F. A Comparison of 2 Thrombus Aspiration Devices With Histopathological Analysis of Retrieved Material in Patients Presenting With ST-Segment Elevation Myocardial Infarction. JACC: Cardiovascular Interventions 1(3): , Vlaar, P. J., Svilaas, T., van der Horst, I. C., Diercks, G. F. H., Fokkema, M. L., de Smet, B. J. G. L., van den Heuvel, A. F. M., Anthonio, R. L., Jessurun, G. A., Tan, E. S., Suurmeijer, A. J. H., Zijlstra, F. Cardiac death and reinfarction after 1 year in the thrombus aspiration during percutaneous coronary intervention in acute myocardial infarction study (TAPAS): a 1-year follow-up study. Lancet 371(9628): , GUIDE Annual Publication Report

15 Vlaar, P. J., Svilaas, T., Damman, K., de Smet, B. J. G. L., Tijssen, J. G. P., Hillege, H. L., Zijlstra, F. Impact of Pretreatment With Clopidogrel on Initial Patency and Outcome in Patients Treated With Primary Percutaneous Coronary Intervention for ST- Segment Elevation Myocardial Infarction A Systematic Review. Circulation 118(18): , Vlaar, P. J., Diercks, G. F., Svilaas, T., Vogelzang, M., de Smet, B. J., van den Heuvel, A. F., Anthonio, R. L., Jessurun, G. A., Tan, E. S., Suurmeijer, A. J., Zijlstra, F. The Feasibility and Safety of Routine Thrombus Aspiration in Patients With Non-ST-Elevation Myocardial Infarction. Catheterization and Cardiovascular Interventions 72(7): , Vlaar, P. J., Svilaas, T., Zijlstra, F. Thrombus aspiration during percutaneous coronary intervention - Reply. Lancet 372(9643): , Vogelzang, M., Loef, B. G., Regtien, J. G., van der Horst, I. C. C., van Assen, H., Zijlstra, F., Nijsten, M. W. N. Computer-assisted glucose control in critically ill patients. Intensive Care Medicine 34(8): , Voors, A. A., de Jong, R. M. Treating diastolic heart failure. Heart 94(8): , Westenbrink, B. D., de Boer, R. A., Voors, A. A., van Gilst, W. H., van Veldhuisen, D. J. Anemia in chronic heart failure: etiology and treatment options. Current Opinion in Cardiology 23(2): , Westenbrink, B. D., Oeseburg, H., Kleijn, L., van der Harst, P., Belonje, A. M. S., Voors, A. A., Schoemaker, R. G., de Boer, R. A., van Veldhuisen, D. J., van Gilst, W. H. Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia. Cardiovascular Drugs and Therapy 22(4): , Xu, Y., Bulikema, H., van Gilst, W. H., Henning, R. H. Caveolae and endothelial dysfunction: Filling the caves in cardiovascular disease. European Journal of Pharmacology 585(2-3): , Zhao, J. Y., Cheema, F. A., Bremner, J. D., Goldberg, J., Su, S., Snieder, H., Maisano, C., Jones, L., Javed, F., Murrah, N., Le, N. A., Vaccarino, V. Heritability of carotid intima-media thickness: A twin study. Atherosclerosis 197(2): , Zhu, H., Yan, W., Tan, Y., Li, K., Kapuku, G., Treiber, F. A., Su, S., Harshfield, G. A., Snieder, H., Dong, Y. Adhesion Molecule Polymorphisms and Pulse Wave Velocity in American Youth. Twin Research and Human Genetics 11(5): , Zhu, H. D., Guo, D. H., Li, K., Yan, W. L., Tan, Y. D., Wang, X. L., Treiber, F. A., Chao, J. L., Snieder, H., Dong, Y. B. Prostasin: A possible candidate gene for human hypertension. American Journal of Hypertension 21(9): , Zijistra, F. Should we revascularize patients with moderate coronary lesions and borderline fractional flow reserve measurements? Catheterization and Cardiovascular Interventions 71(4): , Zijlstra, F. A novel delta-protein-kinase inhibitor for adjunctive therapy during percutaneous coronary intervention. Nature Clinical Practice Cardiovascular Medicine 5(8): , Zijlstra, F. How to remove thrombus prior to stenting in patients with acute myocardial infarction? Catheterization and Cardiovascular Interventions 72(2): 204, Zijlstra, F. The paramount importance of 12-lead electrocardiography in the management of patients with acute myocardial infarction. Catheterization and Cardiovascular Interventions 71(5): 613, Wiesfeld, A. C. P., van Gelder, I. C. A family with abnormal electrocardiograms: part II. Europace 10(10): , Wiesfeld, A. C. P., van Gelder, I. C. A family with abnormal electrocardiograms: part I. Europace 10(10): , Wijpkema, J. S., Anthonio, R. L., Jessurun, G. A. J., Dijk, W. A., Tio, R. A., Zijlstra, F. Restenosis begets restenosis: implications for stent selection. Netherlands Heart Journal 16(11): , Wilkoff, B. L., Williamson, B. D., Stern, R. S., Moore, S. L., Lu, F., Lee, S. W., Birgersdotter-Green, U. M., Wathen, M. S., van Gelder, I. C., Heubner, B. M., Brown, M. L., Holloman, K. K. Strategic programming of detection and therapy parameters in implantable cardioverter-defibrillators reduces shocks in primary prevention patients - Results from the PREPARE (Primary Prevention Parameters Evaluation) study. Journal of the American College of Cardiology 52(7): , Wong, L. S. M., de Boer, R. A., Samani, N. J., van Veldhuisen, D. J., Harst, P. D. Telomere biology in heart failure. European Journal of Heart Failure 10(11): , GUIDE Annual Publication Report

16 INSTITUTE FOR PHARMACOEPIDEMIOLOGY AND DRUG POLICY PEDP Dissertations de Vries, T. W. Improving care in paediatric asthma: patients, prescriptions, pharmacovigilance, pathogens, and particles. (2008) de Jong-van den Berg, L. T. W. and Duiverman, E. J. Reinders, M. K. Practice research in the field of gout: clinical pharmacology of antihyperuricemic drugs. (2008) Brouwers, J. R. B. J. and van de Laar, M. A. F. J. Smink, M. E. Benzodiazepines and traffic safety. Forensic, analytical-toxicological and epidemiological aspects of driving under the influence of benzodiazepines. (2008) Uges, D. R. A., Egberts, A. C. G., and de Gier, J. J. van Hulst, M. Health Economics of blood transfusion safety. (2008) Postma, M. J. and Smit Sibinga, C. Th. Journal Articles Al Hadithy, A. F., Wilffert, B., Stewart, R. E., Looman, N. M., Bruggeman, R., Brouwers, J. R., Matroos, G. E., van Os, J., Hoek, H. W., van Harten, P. N. Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: Differences in association with dopamine and serotonin receptors. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 147B(6): , al Hadithy, A. F. Y., Wilffert, B., Bruggeman, R., Brouwers, J. R. B. J. The impact of MDR1 polymorphisms on prolactin concentrations in patients treated with risperidone. Progress in Neuro-Psychopharmacology & Biological Psychiatry 32(2): , Bakker, M. K., Kolling, P., van den Berg, P. B., de Walle, H. E. K., van den Berg, L. T. W. D. Increase in use of selective serotonin reuptake inhibitors in pregnancy during the last decade, a population-based cohort study from the Netherlands. British Journal of Clinical Pharmacology 65(4): , Bakker, M. K., de Walle, H. E. K., de Jong-van den Berg, L. T. W. Problem of using cases with genetic anomalies as a reference group in case-control studies on drug use and birth defects. Reply to Martínez-Frías and Rodríguez-Pinilla. Clinical and Molecular Teratology 82(Birth defects research Part A,): 175- (letter), Bakker, M. K., de Walle, H. E. K., de Jong-van den Berg, L. T. W. Reply to Martínez-Frías and Rodríguez-Pinilla. Birth Defects Research (part A) 82: 175-(letter), Beinema, M. J., Brouwers, J. R. B. J., Schalekamp, T., Wilffert, B. Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb Haemost 100: , Boersma, C., Postma, M. J., Visser, S. T., Atthobari, J., de Jong, P. E., den Berg, L. T. W. D., Gansevoort, R. T. Baseline albuminuria predicts the efficacy of blood pressure-lowering drugs in preventing cardiovascular events. British Journal of Clinical Pharmacology 65(5): , Boersma, C., Atthobari, J., van den Berg, P. B., Visser, S. T., de Jongvan den Berg, L. T. W., Postma, M. J. Farmaco-economische analyse bij behandeling van hypertensie met angiotensine-iiantagonisten. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(1): 2-7, Boersma, C., Voors, A. A., Postma, M. J. Losartan is cost-effective in the treatment of hypertension in patients with left ventricular hypertrophy. Pharmaceutisch Weekblad 143(7): 32-36, Boersma, C., Voors, A. A., Postma, M. J. Losartan is kosteneffectief in de behandeling van hypertensie bij patiënten met linkerventrikelhypertrofie. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(2): 32-36, Brouwers, J. R. B. J., Vogel, D., ten Have, P., van Asselt, D. Z. B. IJzergebreksanemie bij ouderen. Patient Care 35(12): 27-31, Brouwers, J. R. B. J., ten Brug, E., Taxis, K. Medicatiereview bij ouderen. Patient Care juli/augustus: 26-30, Brouwers, J. R. B. J., Klok, R. M. Protonpompremmers. Patient Care 35(2): 8-10, Brouwers, J. R. B. J., Brinkman, I. H., de Gier, J. J. Therapie(on)trouw bij de oudere patiënt. Patient Care oktober: 9-12, Cornel, M. C., de Smit, D. J., de Jong-van den Berg, L. T. W. Toevoeging van foliumzuur aan brood aan te bevelen. Nederlands Tijdschrift voor Geneeskunde 152(28): 1568, Cornel, M. C., de Smit, D. J., de Jong-van den Berg, L. T. W. Tóch advies op pildoosje. Na verrijking voedsel met foliumzuur. Pharmaceutisch Weekblad april: 17, de Jong-van den Berg, L. T. W. Monitoring of the folic acid supplementation program in the Netherlands. Folate and vitamin B 12 deficiencies: proceedings of a WHO technical consultation held october, 2005, in Geneva, Switzerland. Food and Nutrition Bulletin 29(2): , de Jong, J., van den Berg, P. B., de Vries, T. W., de Jong-van den Berg, L. Antibiotic drug use of children in the Netherlands from 1999 till European Journal of Clinical Pharmacology 64(9): , GUIDE Annual Publication Report

17 de Jong, J., van den Berg, P. B., de Vries TW, de Jong-van den Berg, L. T. W. Meer voorschriften voor flucloxacilline bij kinderen in zomer en vroege herfst door toename van impetigo. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(7): , de Jong, J., van den Berg, P. B., de Vries, T. W., de Jong-van den Berg. More flucloxacillin prescriptions for children in summer and early autumn because of increased impetigo. Pharmaceutisch Weekblad 143(38): , de Langen, J., van Hunsel, F., Passier, A., de Jong-van den Berg, L. T. W., van Grootheest, A. C. Adverse drug reaction reporting by patients in the Netherlands - Three yeaes of experience. Drug Safety 31(6): , De Smedt, R. H. E., Jaarsma, T., van den Broek, S. A. J., Haaijer- Ruskamp, F. M. Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. British Journal of Clinical Pharmacology 66(2): , de Vries, R., van Bergen, J. E. A. M., de Jong-van den Berg, Postma, M. J. Cost-utility of repeated screening for chlamydia trachomatis. Value in Health 11(2): , de Vries, R., Daenen, S., Tolley, K., Glasmacher, A., Prentice, A., Howells, S., Christopherson, H., de Jong-van den Berg, Postma, M. J. Cost effectiveness of itraconazole in the prophylaxis of invasive fungal infections. Pharmacoeconomics 26(1): 75-90, de Walle, H. E. K., den Berg, L. T. W. D. Ten years after the Dutch public health campaign on folic acid: the continuing challenge. European Journal of Clinical Pharmacology 64(5): , Deschepper, R., Grigoryan, L., Lundborg, C. S., Hofstede, G., Cohen, J., Van Der Kelen, G., Deliens, L., Haaijer-Ruskamp, F. M. Are cultural dimensions relevant for explaining cross-national differences in antibiotic use in Europe? BMC Health Services Research 8 AR 123 DI / Dobre, D., de Jongste, M. J. L., Haaijer-Ruskamp, F. M., Sanderman, R., van Veldhuisen, D. J., Ranehor, A. V. The enigma of quality of life in patients with heart failure. International Journal of Cardiology 125(3): , Dolk, H., Jentink, J., Loane, M., Morris, J., de Jong-van den Berg, L. T. W. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 71: , Duyvendak, M., Naunton, M., van Roon, E. N., Bruyn, G. A. W., Brouwers, J. R. B. J. Systematic review of trends in prophylaxis of corticosteroid-induced osteoporosis: the need for standard audit guidelines. Osteoporosis International 19: , Eleveld, S. C., Koop, H. I., de Vries TW, van den Berg, P. B., de Jong-van den Berg, L. T. W. Laxantiagebruik bij kinderen, reden voor zorg? Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(8): , Faber, A., van Agthoven, M., Kalverdijk, L. J., Tobi, H., de Jong-van den Berg, L. T. W., Annemans, L. J. P., Postma, M. J. Long-acting methylphenidate-oros in youths with attention-deficit hyperactivity disorder suboptimally controlled with immediaterelease methylphenidate - A study of cost effectiveness in the Netherlands. Cns Drugs 22(2): , Ferko, N., Postma, M., Gallivan, S., Kruzikas, D., Drummond, M. Evolution of the health economics of cervical cancer vaccination. Vaccine 26(Suppl. 5): F3-F15, Gallivan, S., Pagel, C., Utley, M., Franklin, B. D., Taxis, K., Barber, N. A technical note concerning non-adherence to drug therapy: exact expression for the mean and variance of drug concentration. Health Care Management Science 11: , Gallivan, S., Taxis, K., Franklin, B. D., Barber, N. Is the Principle of a Stable Heinrich Ratio a Myth? Drug Safety 31(8): , Grigoryan, L., Burgerhof, J. G. M., Degener, J. E., Deschepper, R., Lundborg, C. S., Monnet, D. L., Scicluna, E. A., Birkin, J., Haaijer- Ruskamp, F. M. Determinants of self-medication with antibiotics in Europe: the impact of beliefs, country wealth and the healthcare system. Journal of Antimicrobial Chemotherapy 61(5): , Härmark, L. V. D., van Grootheest, A. C. Actieve bewaking van nieuwe diabetesmiddelen. Patient Care juni: 50-52, Härmark, L. V. D., van Grootheest, A. C. Pharmacovigilance: methods, recent developments and future perspectives. European Journal of Clinical Pharmacology Heisterkamp, S. H., de Vries, R., Sprenger, H. G., Hubben, G. A. A., Postma, M. J. Comment on 'Estimation and prediction of the HIV-AIDS-epidemic under conditions of HAART using mixtures of incubation time distributions'. Statistics in Medicine 27(11): , Heisterkamp, S. H., de Vries, R., Sprenger, H. G., Hubben, G. A. A., Postma, M. J. Estimation and prediction of the HIV-AIDSepidemic under conditions of HAART using mixtures of incubation time distributions. Statistics in Medicine 27(6): , Hubben, G. A. A., Bishai, D., Pechlivanoglou, P., Cattelan, A. M., Grisetti, R., Facchin, C., Compostella, F. A., Bos, J. M., Postma, M. J., Tramarin, A. The societal burden of HIV/AIDS in Northern Italy: An analysis of costs and quality of life. Aids Care- Psychological and Socio-Medical Aspects of Aids/HIV 20(4): , Jentink, J., van de Vrie-Hoekstra, N. W., de Jong-van den Berg, Postma, M. J. Economic evaluation of folic acid food fortification in The Netherlands. European Journal of Public Health 18(3): , GUIDE Annual Publication Report

18 Kalverdijk, L. J., Tobi, H., van den Berg, P. B., Buiskool, J., Wagenaar, L., Minderaa, R. B., de Jong-van Berg, L. T. W. Use of antipsychotic drugs among dutch youths between 1997 and Psychiatric Services 59(5): , Klappe-Sabadi, G., Jansman, F. G. A., Honkoop, H. A., Otter, R., Willemse, P. H. B., Brouwers, J. R. B. J. Regionale verschillen in voorschrijfgedrag opnieuw getoetst. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(7): , Loonen, A. J. M. Kennis van zaken. Werking antidepressiva. Pharmaceutisch Weekblad mei: 10, Loonen, A. J. M. Wat telt, is of het hélpt. Hoeze werkt SSRI niet beter dan placebo? Pharmaceutisch Weekblad april: 19, Martirosyan, L., Braspenning, J., Denig, P., de Grauw, W. J. C., Bouma, M., Storms, F., Haaijer-Ruskamp, F. M. Prescribing quality indicators of type 2 diabetes mellitus ambulatory care. Quality & Safety in Health Care 17(5): , Monster-Simons, M. H., van Grootheest, A. C. Geen maagzuur meer, maar wel borstvorming. Gynaecomastic tijdens gebruik van protonpompremmers. Pharmaceutisch Weekblad juli: 38-39, Postma, M. J. Besparing door substitutie van statines. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(3): 72, Postma, M. J., Beardsworth, P., Wilschut, J. C. Cost effectiveness of oseltamivir treatment of influenza: a critique of published methods and outcomes. J. Med. Econ. 11(4): , Postma, M. J., de Vries, R., Welte, R., Edmunds, W. J. Health economic methodology illustrated with recent work on Chlamydia screening: the concept of extended dominance. Sexually Transmitted Infections 84(2): , Postma, M. J. Kosteneffectiviteit van hepatitis-b-vaccinatie. Nederlands farmaceutisch onderzoek in de internationale literatuur. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(4): 79, Postma, M. J., Boersma, C., Gansevoort, R. T. Pharmacoeconomics in nephrology: considerations on cost-effectiveness of screening for albuminuria. Nephrology Dialysis Transplantation 23(4): , Postma, M. J. Public health economics of vaccines in the Netherlands: methodological issues and applications. Journal of Public Health 16: , Reinders, M. K., Haagsma, C., Jansen, T. L. T. A., van Roon, E. N., Delsing, J., van de Laar, M. A. F. J., Brouwers, J. R. B. J. A randomised controlled trial on the efficacy and tolerability with dose-escalation of allopurinol mg/day versus benzbromarone mg/day in patients with gout. Annals of the Rheumatic Diseases DOI: /ard Reinders, M. K., van Roon, E. N., Jansen, T. L. T. A., Delsing, J., van de Laar, M. A. F. J., Brouwers, J. R. B. J. Effectiviteit en verdraagbaarheid van urinezuurverlagende behandeling. Gerandomiseerd gecontroleerd onderzoek van benzbromaron versus probenecide bij jicht na falen allopurinol. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(1): 19-23, Reinders, M. K., van Roon, E. N., Jansen, T. L. T. A., Delsing, J., Griep, E. N., Hoekstra, M., van de Laar, M. A. F. J., Brouwers, J. R. B. J. Efficacy and tolerability of urate lowering drugs in gout: a randomised trial of benzbromarone versus probenecid after failure of allopurinol. Annals of the Rheumatic Diseases Online first DOI: /ard Reinders, M. K., Jansen, T. L. T. A. Survey on management of gout among Dutch rheumatologists. Annals of the Rheumatic Diseases 67: 1049-(letter), Rozenbaum, M. H., Verweel, G., Folkerts, D. K. F., Dronkers, F., van den Hoek, J. A. R., Hartwig, N. G., de Groot, R., Postma, M. J. Cost-effectiveness estimates for antenatal HIV testing in the Netherlands. International Journal of STD & AIDS 19(10): , Rozenbaum, M. H., van Hoek, A. J., Vegter, S., Postma, M. J. Costeffectiveness of varicella vaccination programs: an update of the literature. Expert Review of Vaccines 7(6): , Sancar, A. A., Yegenoglu, S., de Vries, R., Postma, M. J., Simsek, N., Pechlivanoglou, P., Unal, S. Vancomycin vs teicoplanin in the treatment of Gram-positive infections: a pharmacoeconomic analysis in a Turkish University Hospital. Pharmacy World & Science 30(6): , Sander, B., Nizam, A., Garrison, L. P., Postma, M. J., Halloran, M. E., Longini, I. M. Economic evaluation of influenza pandemic mitigation strategies in the United States using a stochastic microsimilation transmission model. Value in Health DOI: Scheepers-Hoeks, A. M. J. W., Wessels-Basten, S. J. W., Scherders, M. J. W. T., Bravenboer, B., Loonen, A. J. M., Kleppe, R. T., Grouls, R. J. E. Schizofrenie en antipsychotica: samenhang met het metabool syndroom. Tijdschrift voor Psychiatrie 50(10): , Schorr, S. G., Slooff, C. J., Postema, R., Van Oven, W., Schilthuis, M., Bruggeman, R., Taxis, K. A 12-month follow-up study of treating overweight schizophrenic patients with aripiprazole. Acta Psychiatrica Scandinavica 118(3): , Schorr, S. G., Loonen, A. J. M., Brouwers, J. R. B. J., Taxis, K. A cross-sectional study of prescribing patterns in chronic psychiatric patients living in sheltered housing facilities. International Journal of Clinical Pharmacology and Therapeutics 46(3): , Smink, B. E., Hofman, B. J. A., Dijkhuizen, A., Lusthof, K. J., de Gier, J. J., Egberts, A. C. G., Uges, D. R. A. The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam. British Journal of Clinical Pharmacology 66(4): , GUIDE Annual Publication Report

19 Smink, B. E., Movig, K. L. L., Lusthof, K. J., de Gier, J. J., Uges, D. R. A., Egberts, A. C. G. The Relation Between the Use of Psychoactive Substances and the Severity of the Injury in a Group of Crash-Involved Drivers Admitted to a Regional Trauma Center. Traffic Injury Prevention 9(2): , Smink, B. E., Lusthof, K. J., de Gier, J. J., Uges, D. R. A., Egberts, A. C. G. The relation between the blood benzodiazepine concentration and performance in suspected impaired drivers. Journal of Forensic and Legal Medicine 15: , ter Horst, P. G. J., Jansman, F. G. A., van Lingen, R. A., Smit, J.-P., de Jong-van den Berg, L. T. W., Brouwers, J. R. B. J. Pharmacological aspects of neonatal antidepressant withdrawal. Obstetrical & Gynecological Survey 63(4): , Tramarin, A., Gennaro, N., Compostella, F. A., Gallo, C., Bonga, L. J. W., Postma, M. J. HCV screening to enable early treatment of hepatitis C: A mathematical model to analyse costs and outcomes in two populations. Current Pharmaceutical Design 14(17): , van de Vrie-Hoekstra, N. W., de Vries, T. W., van den Berg, P. B., Brouwer, O. F., de Jong-van den Berg. Antiepileptic drug utilization in children from a study from the Netherlands. European Journal of Clinical Pharmacology 64(10): , van Doormaal, J. E., Mol, P. G. M., van den Bemt, P. M. L. A., Zaal, R. J., Egberts, A. C. G., Kosterink, J. G. W., Haaijer-Ruskamp, F. M. Reliability of the assessment of preventable adverse drug events in daily clinical practice. Pharmacoepidemiology and Drug Safety 17(7): , van Gool, A. R., van der Velden, M. T., Oosten, A. W., van Meerten, E., Verhoeven, W. M. A., Loonen, A. J. M. Chemotherapie bij gebruik van clozapine; een verhoogde kans op agrunulocytose? Tijdschrift voor Psychiatrie 50(10): , van Hulst, M., Sagoe, K. W. C., Vermande, J. E., van der Schaaf, I. P., Adriani, W. P. A. V., Torpey, K., Ansah, J., Mingle, J. A. A., Sibinga, C. T. S., Postma, M. J. Cost-effectiveness of HIV screening of blood donations in Accra (Ghana). Value in Health 11(5): , van Hulst, M., Owutsu-Ofori, S., Sarkodie, F., Nsiah-Asare, A., Candotti, D., Postma, M. J., Allain, J. P. Cost-effectiveness of predonation screening blood donors with rapid tests and subsequent nucleic acid amplification testing of blood donations in a resource-poor setting. Vox Sanguinis 95: 261, van Hunsel, F. P. A. M., de Smet, P. A. G. M., van Klei, N., van Grootheest, A. C. Indonesische kruidenthee bevat ongewenste westerse geneesmiddelen. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(7): , Vegter, S., de Jong-van den Berg, L. T. W. Choice of first antihypertensive-comparison between the Irish and Dutch setting. British Journal of Clinical Pharmacology 66(2): , Vegter, S., Boersma, C., Rozenbaum, M., Wilffert, B., Navis, G., Postma, M. J. Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes - A systematic review on content and adherence to guidelines. Pharmacoeconomics 26(7): , Vehof, J., Postma, M. J., Bruggeman, R., den Berg, L. T. W. D., Van Den Berg, P. D., Stolk, R. P., Burger, H. Predictors for Starting Depot Administration of Risperidone in Chronic Users of Antipsychotics. Journal of Clinical Psychopharmacology 28(6): , Voorham, J., Denig, P., Wolffenbuttel, B. H. R., Haaijer-Ruskamp, F. M. Cross-sectional versus sequential quality indicators of risk factor management in patients with type 2 diabetes. Medical Care 46(2): , Voorham, J., Haaijer-Rustcamp, F. M., Stolk, R. P., Wolffenbuttel, B. H. R., Denig, P. Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes. Diabetes Care 31(3): , Vroom, F., van den Berg, P. B., de Jong-van den Berg, L. T. W. Prescribing of NSAIDs and ASA during pregnancy; do we need to be more careful? British Journal of Clinical Pharmacology 65(2): , Vroom, F., van Roon, E. N., van den Berg, P. B., Brouwers, J. R. B. J., de Jong-van den Berg, L. T. W. Prescribing of sulfasalazine, azathioprine and methotrexate round pregnancy - a descriptive study. Pharmacoepidemiology and Drug Safety 17(1): 52-61, Vroom, F., van de Laar, M. A. F. J., van Roon, E. N., Brouwers, J. R. B. J., de Jong-van den Berg, L. T. W. Treatment of pregnant and non-pregnant rheumatic patients: a survey among Dutch rheumatologists. Journal of Clinical Pharmacy and Therapeutics 33(1): 39-44, Wilffert, B., al Hadithy, A. F. Y., Sing, V. J., Matroos, G. E., Hoek, H. W., van Os, J., Bruggeman, R., Brouwers, J. R. B. J., van Harten, P. N. The role of dopamine D 3, 5-HT2 A and 5-HT2 C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African-Caribbean patients under chronic antipsychotic treatment. Journal of Psychopharmacology Online first DOI: / Zeldenrust, M. E., Rahamat-Langendoen, J. C., Postma, M. J., van Vliet, J. A. The value of ProMED-mail for the Early Warning Committee in the Netherlands: more specific approach recommended. Euro Surveillance: Bulletin Europeen sur les Maladies Transmissibles = Europeach Communicable Disease Bulletin 13(6) Zito, J. M., Safer, D. J., de Jong-van den Berg, L. T. W., Janhsen, K., Fegert, J. M., Gardner, J. F., Glaeske, G., Valluri, S. C. A threecountry comparison of psychotropic medication prevalence in youth. Child and Adolescent Psychiatry and Mental Health DOI: / GUIDE Annual Publication Report

20 Dissertations GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD GRIAC Boelens, M. C. Molecular genetic studies in epithelial cells of lung cancer and COPD patients. (2008) Groen, H. J. M., Postma, D. S, Timens, W, and van den Berg, J. H. M. Brandsma, C. A. The inflammatory response in COPD : in mice and men. (2008) Kerstjens, H. A. M., Timens, W, Postma, D. S, and Hylkema, M. N. de Vries, T. W. Improving care in paediatric asthma: patients, prescriptions, pharmacovigilance, pathogens, and particles. (2008) de Jong-van den Berg, L. T. W. and Duiverman, E. J. Didraga, M. A. Analytical approaches towards structural characterization of human lung decorin. (2008) Postma, D. S, Bischoff, R., Kerstjens, H. A. M., and Barroso, B. Diemen, C. C. van. Genetics of lung function decline and COPD development. (2008) Postma, D. S and Boezen, H. M. Duiverman, M. L. Severe Chronic Obstructive Pulmonary Disease : assessment of respiratory muscle activity and the benefits of noninvasive ventilation. (2008) Kerstjens, H. A. M., Wijkstra, P. J., and Wempe, J. B. Liesker, J. J. W. COPD : a multifaceted disease. (2008) Kerstjens, H. A. M., Postma, D. S, Timens, W, and ten Hacken, N. H. T. Vlieg-Boerstra, B. Standardization, validation and outcome of double-blind, placebo-controlled food challenges in children. (2008) Dubois, A. E. J., Duiverman, E. J., Heide, S. van der, and Bijleveld, C. M. A. Versluis, M. Adenosine and its receptors : translational studies in asthma and COPD. (2008) Timens, W, Postma, D. S, and Hylkema, M. N. Journal Articles Abello, N., Geurink, P. P., van der Toorn, M., van Oosterhout, A. J. M., Lugtenburg, J., van der Marel, G. A., Kerstjens, H. A. M., Postma, D. S., Overkleeft, H. S., Bischoff, R. Poly(ethylene glycol)- Based Stable Isotope Labeling Reagents for the Quantitative Analysis of Low Molecular Weight Metabolites by LC-MS. Analytical Chemistry 80(23): , Ambrosino, N., Casaburi, R., Ford, G., Goldstein, R., Morgan, M. D. L., Rudolf, M., Singh, S., Wijkstra, P. J. Developing concepts in the pulmonary rehabilitation of COPD. Respiratory Medicine 102(Suppl. 1): S17-S26, Bathoorn, E., Kerstjens, H. A. M., Postma, D., Timens, W., MacNee, W. Airways inflammation and treatment during acute exacerbations of COPD. International Journal of COPD 3(2): , Bathoorn, E., Liesker, J. J. W., Postma, D. S., Boorsma, M., Bondesson, E., Koeter, G. H., Kauffman, H. F., van Oosterhout, A. J. M., Kerstjens, H. A. M. Anti-inflammatory Effects of Combined Budesonide/Formoterol in COPD Exacerbations. Copd-Journal of Chronic Obstructive Pulmonary Disease 5(5): , Blok, B. M. J. F., DunnGalvin, A., Viieg-Boerstra, B. J., Elberink, J. N. G. O., Duiverman, E. J., Hourihane, J. O., Dubois, A. E. J. Development and validation of the self-administered Food Allergy Quality of Life Questionnaire for adolescents. Journal of Allergy and Clinical Immunology 122(1): , Bottema, R. W. B., Reijmerink, N. E., Kerkhof, M., Koppelman, G. H., Stelma, F. F., Gerritsen, J., Thijs, C., Brunekreef, B., van Schayck, C. P., Postma, D. S. Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. European Respiratory Journal 32(3): , Brandsma, C. A., Hylkema, M. N., van der Strate, B. W. A. D., Slebos, D. J., Luinge, M. A., Geerlings, M., Timens, W., Postma, D. S., Kerstjens, H. A. M. Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells? Respiratory Research 9 AR 17 DI / : 17, Brandsma, C. A., Hylkema, M. N., Luinge, M. A., Geerlings, M., Klok, P. A., Cassee, F. R., Timens, W., Postma, D. S., Kerstjens, H. A. M. Nitrogen dioxide exposure attenuates cigarette smokeinduced cytokine production in mice. Inhalation Toxicology 20(2): , Brouwer, A. F. J., Roorda, R. J., Dulverman, E. J., Brand, P. L. P. Reference values for peak flow and FEV1 variation in healthy schoolchildren using home spirometry. European Respiratory Journal 32(5): , Cerveri, I., Corsico, A. G., Accordini, S., Niniano, R., Ansaldo, E., Anto, J. M., Kunzli, N., Janson, C., Sunyer, J., Jarvis, D., Svanes, C., Gislason, T., Heinrich, J., Schouten, J. P., Wjst, M., Burney, P., de Marco, R. Underestimation of airflow obstruction among young adults using FEV1/FVC < 70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes. Thorax 63(12): , Chen, C. M., Gehring, U., Wickman, M., Hoek, G., Giovannangelo, M., Nordling, E., Wijga, A., de, Jongste J., Pershagen, G., Almqvist, C., Kerkhof, M., Bellander, T., Wichmann, H. E., Brunekreef, B., Heinrich, J. Domestic cat allergen and allergic sensitisation in young children. International Journal of Hygeine and Environmental Health 211(3-4): , Chen, C. M., Gehring, U., Wickman, M., Hoek, G., Giovannangelo, M., Nordling, E., Wijga, A., de Jongste, J., Pershagen, G., Almqvist, GUIDE Annual Publication Report

21 C., Kerkhof, M., Bellander, T., Wichmann, H. E., Brunekreef, B., Heinrich, J. Domestic cat allergen and allergic sensitisation in young children. International Journal of Hygiene and Environmental Health 211(3-4): , Cohen, J., Douma, W. R., ten Hacken, N. H. T., Vonk, J. M., Oudkerk, M., Postma, D. S. Ciclesonide improves measures of small airway involvement in asthma. European Respiratory Journal 31(6): , Cohen, J., Douma, W. R., van Ooijen, P. M. A., Willems, T. P., Dicken, V., Kuhnigk, J. M., ten Hacken, N. H. T., Postma, D. S., Oudkerk, M. Localization and Quantification of Regional and Segmental Air Trapping in Asthma. Journal of Computer Assisted Tomography 32(4): , Cohen, J., Douma, W. R., ten Hacken, N. H. T., Oudkerk, M., Postma, D. S. Physiology of the small airways: A gender difference? Respiratory Medicine 102(9): , de Vries TW, van Roon, E. N., Duiverman, E. J. Inhaled corticosteroids do not affect behaviour. Acta Paedriatrica 97(6): , de Vries, T. W., van Roon, E. N., Duiverman, E. J. Inhaled corticosteroids do not affect behaviour. Acta Paedriatrica 97(6): , Denham, S., Koppelman, G. H., Blakey, J., Wjst, M., Ferreira, M. A., Hall, I. P., Sayers, I. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respiratory Research 9 AR 38 DI / Dijkstra, A., Koppelman, G. H., Vonk, J. M., Bridnenberg, M., Schouten, J. P., Postma, D. S. Pharmacogenomics and outcome of asthma: No clinical application for long-term steroid effects by CRHR1 polymorphisms. Journal of Allergy and Clinical Immunology 121(6): , Duiverman, M. L., Wempe, J. B., Bladder, G., Kerstjens, H. A. M., Wijkstra, P. J. Health-related quality of life in COPD patients with chronic respiratory failure. European Respiratory Journal 32(2): , Duiverman, M. L., Wempe, J. B., Bladder, G., Jansen, D. F., Kerstjens, H. A. M., Zijlstra, J. G., Wijkstra, P. J. Nocturnal noninvasive ventilation in addition to rehabilitation in hypercapnic patients with COPD. Thorax 63(12): , DunnGalvin, A., de BlokFlokstra, B. M. J., Burks, A. W., Dubois, A. E. J., Hourihane, J. O. Food allergy QoL questionnaire for children aged 0-12 years: content, construct, and cross-cultural validity. Clinical and Experimental Allergy 38(6): , Flapper, B. C. T., Duiverman, E. J., Gerritsen, J., Postema, K., van der Schans, C. P. Happiness to be gained in paediatric asthma care. European Respiratory Journal 32(6): , Gerritsen, J. Airway responsiveness in teenagers is becoming sexier. American Journal of Respiratory and Critical Care Medicine 178(4): , Gosens, R., Mutawe, M., Martin, S., Basu, S., Bos, S. T., Tran, T., Halayko, A. J. Caveolae and caveolins in the respiratory system. Current Molecular Medicine 8(8): , Gosens, R., Roscioni, S. S., Dekkers, B. G. J., Pera, T., Schmidt, M., Schaafsma, D., Zaagsma, J., Meurs, H. Pharmacology of airway smooth muscle proliferation. European Journal of Pharmacology 585(2-3): , Gosens, R., Meurs, H., Schmidt, M. The GSK-3/beta-cateninsignalling axis in smooth muscle and its relationship with remodelling. Naunyn-Schmiedebergs Archives of Pharmacology 378(2): , Gosman, M. M., Postma, D. S., Vonk, J. M., Rutgers, B., Lodewijk, M., Smith, M., Luinge, M. A., ten Hacken, N. H. T., Timens, W. Association of mast cells with lung function in chronic obstructive pulmonary disease. Respiratory Research 9 AR 64 DI / : 64, Groenewegen, K. H., Postma, D. S., Hop, W. C. J., Wielders, P. L. M. L., Schlosser, N. J. J., Wouters, E. F. M. Increased systemic inflammation is a risk factor for COPD exacerbations. Chest 133(2): , Halayko, A. J., Tran, T., Gosens, R. Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins. Proceedings of the American Thoracic Society 5(1): 80-88, 1-1- Heijink, I. H., Kauffman, H. F., Vellenga, E., Veltman-Starkenburg, C. A., Postma, D. S., de Monchy, J. G. R. Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma. International Archives of Allergy and Immunology 145(2): , Holloway, J. W., Koppelman, G. H. 17q21 Variants and Asthma - Questions and Answers. New England Journal of Medicine 359(19): , Huijsmans, R. J., de Haan, A., ten Hacken, N. N. H. T., Straver, R. V. M., van't Hu, A. J. The clinical utility of the GOLD classification of COPD disease severity in pulmonary rehabilitation. Respiratory Medicine 102(1): , Ivanova, J. I., Birnbaum, H. G., Hsieh, M., Yu, A. P., Seal, B., van der Molen, T., Emani, S., Rosiello, R. A., Colice, G. L. Adherence to Inhaled Corticosteroid Use and Local Adverse Events in Persistent Asthma. American Journal of Managed Care 14(12): , Knipping, K., van Esch, E. C. A. M., Wijering, S. C., van der Heide, S., Dubois, A. E., Garssen, J. In Vitro and In Vivo Anti-Allergic Effects of Arctium lappa L. Experimental Biology and Medicine 233(11): , Kooi, E. M. W., Schokker, S., Boezen, H. M., de Vries, T. W., Vaessen-Verberne, A. A. P. H., van der Molen, T., Duiverman, E. J. Fluticasone or montelukast for preschool children with asthmalike symptoms: Randomized controlled trial. Pulmonary Pharmacology & Therapeutics 21(5): , GUIDE Annual Publication Report

22 Koppelman, G. H., Meerman, G. J. T., Postma, D. S. Genetic testing for asthma. European Respiratory Journal 32(3): , Luijk, B., van den Berge, M., Kerstjens, H. A. M., Postma, D. S., Cass, L., Sabin, A., Lammers, J. W. J. Effect of an inhaled adenosine A(2A) agonist on the allergen-induced late asthmatic response. Allergy 63(1): 75-80, Maarsingh, H., Pera, T., Meurs, H. Arginase and pulmonary diseases. Naunyn-Schmiedebergs Archives of Pharmacology 378(2): , Maarsingh, H., Zuidhof, A. B., Bos, I. S. T., van Duin, M., Boucher, J. L., Zaagsma, J., Meurs, H. Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation. American Journal of Respiratory and Critical Care Medicine 178(6): , Maarsingh, H., Zaagsma, J., Meurs, H. Arginine homeostasis in allergic asthma. European Journal of Pharmacology 585(2-3): , Meurs, H., Gosens, R., Zaagsma, J. Airway hyperresponsiveness in asthma: lessons from in vitro model systems and animal models. European Respiratory Journal 32(2): , Nijholt, I. M., Dolga, A. M., Ostroveanu, A., Luiten, P. G. M., Schmidt, M., Eisel, U. L. M. Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation. Cellular Signalling 20(10): , Nunes, R. O., Schmidt, M., Dueck, G., Baarsma, H., Halayko, A. J., Kerstjens, H. A. M., Meurs, H., Gosens, R. GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling. American Journal of Physiology-Lung Cellular and Molecular Physiology 294(6): L1110-L1118, O'Byrne, P. M., Naya, I. P., Kallen, A., Postma, D. S., Barnes, P. J. Increasing Doses of Inhaled Corticosteroids Compared to Adding Long-Acting Inhaled beta(2)-agonists in Achieving Asthma Control. Chest 134(6): , Pillai, S. G., Tang, Y., van den Oord, E., Klotsman, M., Barnes, K., Carlsen, K., Gerritsen, J., Lenney, W., Silverman, M., Sly, P., Sundy, J., Tsanakas, J., von Berg, A., Whyte, M., Ortega, H. G., Anderson, W. H., Helms, P. J. Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes. Clinical and Experimental Allergy 38(3): , Reijmerink, N. E., Postma, D. S., Bruinenberg, M., Nolte, I. M., Meyers, D. A., Bleecker, E. R., Koppelman, G. H. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. Journal of Allergy and Clinical Immunology 122(3): , Roscioni, S. S., Elzinga, C. R., Schmidt, M. Epac: effectors and biological functions. Naunyn-Schmiedebergs Archives of Pharmacology 377: , 5-1- Ruskamp, J. M., Hoekstra, M. O., Postma, D. S., Kerkhof, M., Bottema, R. W., Koppelman, G. H., Rovers, M. M., Wijga, A. H., de Jongste, J. C., Brunekreef, B., Sanders, E. A. Polymorphisms in the Mannan-Binding Lectin Gene Are Not Associated with Questionnaire-Reported Respiratory Tract Infections in Children. Journal of Infectious Diseases 198(11): , Schaafsma, D., Roscioni, S. S., Meurs, H., Schmidt, M. Monomeric G-proteins as signal transducers in airway physiology and pathophysiology. Cellular Signalling 20(10): , Schaafsma, D., Gosens, R., Zaagsma, J., Halayko, A. J., Meurs, H. Rho kinase inhibitors: A novel therapeutical intervention in asthma? European Journal of Pharmacology 585(2-3): , Schaafsma, D., Bos, I. S. T., Zuidhof, A. B., Zaagsma, J., Meurs, H. The inhaled Rho kinase inhibitor Y protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology 295(1): L214-L219, Scheer, M. L. J., Slebos, D. J., Bogchelman, D. H., Timens, W. Pulmonary densities following a hysterectomy, caused by benign metastatic leiomyoma. Nederlands Tijdschrift voor Geneeskunde 152(37): , Schokker, S., Kooi, E. M. W., de Vries, T. W., Brand, P. L. P., Mulder, P. G. H., Duiverman, E. J., van der Molen, T. Inhaled corticosteroids for recurrent respiratory symptoms in preschool children in general practice: Randomized controlled trial. Pulmonary Pharmacology & Therapeutics 21(1): 88-97, Schokker, S., Kooi, E., De Vries, T., Brand, P., Mulder, P., Duiverman, E., van der Molen, T. Inhaled corticosteroids are not useful in young children with respiratory disorders. Huisarts en Wetenschap 51(13): , Scholtens, S., Brunekreef, B., Smit, H. A., Gast, G. C. M., Hoekstra, M. O., de Jongste, J. C., Postma, D. S., Gerritsen, J., Seidell, J. C., Wijga, A. H. Do Differences in Childhood Diet Explain the Reduced Overweight Risk in Breastfed Children? Obesity 16(11): , Sharma, P., Tran, T., Stelmack, G. L., McNeill, K., Gosens, R., Mutawe, M. M., Unruh, H., Gerthoffer, W. T., Halayko, A. J. Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. American Journal of Physiology-Lung Cellular and Molecular Physiology 294(1): L57-L68, Siedlinski, M., van Diemen, C. C., Postma, D. S., Boezen, H. M. Heme oxygenase 1 variations and lung function decline in smokers: proof of replication. Journal of Medical Genetics 45(6): 400, Siedlinski, M., Postma, D. S., van Diemen, C. C., Blokstra, A., Smit, H. A., Boezen, H. M. Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans. American Journal of Respiratory and Critical Care Medicine 178(1): 13-19, GUIDE Annual Publication Report

23 Sly, P. D., Boner, A. L., Bjorksten, B., Bush, A., Custovic, A., Eigenmann, P. A., Gern, J. E., Gerritsen, J., Hamelmann, E., Helms, P. J., Lemanske, R. F., Martinez, F., Pedersen, S., Renz, H., Sampson, H., von Mutius, E., Wahn, U., Holt, P. G. Early identification of atopy in the prediction of persistent asthma in children. Lancet 372(9643): , Snoeck-Stroband, J. B., Lapperre, T. S., Gosman, M. M. E., Boezen, H. M., Timens, W., ten Hacken, N. H. T., Sont, J. K., Sterk, P. J., Hiemstra, P. S. Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies. European Respiratory Journal 31(1): 70-77, Stolk, R. P., Rosmalen, J. G. M., Postma, D. S., de Boer, R. A., Navis, G., Slaets, J. P. J., Ormel, J., Wolffenbuttel, B. H. R. Universal risk factors for multifactorial diseases - LifeLines: a three-generation population-based study. European Journal of Epidemiology 23(1): 67-74, Swanney, M. P., Ruppel, G., Enright, P. L., Pedersen, O. F., Crapo, R. O., Miller, M. R., Jensen, R. L., Falaschetti, E., Schouten, J. P., Hankinson, J. L., Stocks, J., Quanjer, P. H. Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction. Thorax 63(12): , Taher, Y. A., van Esch, B. C. A. M., Hofman, G. A., Henricks, P. A. J., van Oosterhout, A. J. M. 1 alpha,25-dihydroxyvitamin D-3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: Role for IL-10 and TGF-beta. Journal of Immunology 180(8): , Taher, Y. A., Piavaux, B. J. A., Gras, R., van Esch, B. C. A. M., Hofman, G. A., Bloksma, N., Henricks, P. A. J., van Oosterhout, A. J. M. Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model. Journal of Allergy and Clinical Immunology 121(4): , Versluis, M., van den Berge, M., Timens, W., Luijk, B., Rutgers, B., Lammers, J. W. J., Postma, D. S., Hylkema, M. N. Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients. Allergy 63(9): , Versluis, M., Postma, D. S., Timens, W., Hylkema, M. N. Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1. International Immunopharmacology 8(6): , Vlieg-Boerstra, B. J., van der Heide, S. Double-blind, placebo- Controlled food challenges in children. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 33(1): 16-20, Vlieg-Boerstra, B. J., Dubois, A. E. J., van der Heide, S., Bijleveld, C. M. A., Wolt-Plompen, S. A. A., Elberink, J. N. G. O., Kukler, J., Jansen, D. F., Venter, C., Duiverman, E. J. Ready-to-use introduction schedules for first exposure to allergenic foods in children at home. Allergy 63(7): , Vlieg-Boerstra, B. J., Duiverman, E. J., van der Heide, S., Bijleveld, C. M. A., Kukler, J., Dubois, A. E. J. Should children with a history of anaphylaxis to foods undergo challenge testing? Clinical and Experimental Allergy 38(12): , Willemsen, G., van Beijsterveldt, T. C. E. M., van Baal, C. G. C. M., Postma, D., Boomsma, D. I. Heritability of self-reported asthma and allergy: A study in adult Dutch twins, siblings and parents. Twin Research and Human Genetics 11(2): , Willers, S. M., Wijga, A. H., Brunekreef, B., Kerkhof, M., Gerritsen, J., Hoekstra, M. O., de Jongste, J. C., Smit, H. A. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. American Journal of Respiratory and Critical Care Medicine 178(2): , Taylor, D. R., Bateman, E. D., Boulet, L. P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., de Jongste, J. C., Kerstjens, H. A. M., Lazarus, S. C., Levy, M. L., O'Byrne, P. M., Partridge, M. R., Pavord, I. D., Sears, M. R., Sterk, P. J., Stoloff, S. W., Szefler, S. J., Sullivan, S. D., Thomas, M. D., Wenzel, S. E., Reddel, H. K. A new perspective on concepts of asthma severity and control. European Respiratory Journal 32(3): , Telenga, E. D., Kerstjens, H. A. M. Untitled. Pulmonary Pharmacology & Therapeutics 21(2): 430, ten Hacken, N. H. T., de Greef, M. H. Pedometers for monitoring and improvement of the level of physical activity. Nederlands Tijdschrift voor Geneeskunde 152: , van der Deen, M., Homan, S., Timmer-Bosscha, H., Scheper, R. J., Timens, W., Postma, D. S., de Vries, E. G. Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells. International Journal of COPD 3(3): , van der Heide, S., Rijntjes, J. G. M. Specific IgE determinations in children: Fictions and facts. Tijdschrift voor Kindergeneeskunde 76(2): 61-65, GUIDE Annual Publication Report

24 CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES - CLDS Research Line Transport, Metabolism and Target Identification Dissertations Blokzijl, J. Functional regulation of transport proteins in gastrointestinal and liver disease. (2008) Jansen, P. L. M., Moshage, A. J., and Faber, K. N. Dunning, S. Resistance of activated stellate cells to cell death in liver fibrosis : mechanisms and targets for intervention. (2008) Moshage, A. J. Jeganathan, K. B. The mitotic checkpoint: mechanism and biological relevance. (2008) Hofker, M. H. and Deursen, J. M. van Pellicoro, A. Hepatic peroxisome function in health and disease. (2008) Jansen, P. L. M. and Faber, K. N. Svenson, K. L. The development and implementation of a high-throughput phenotyping platform for identification of a new mouse models of cardiovascular disease. (2008) Hofker, M. H., Paigen, B., and Korstanje, R. Vrenken, T. E. Mechanisms and prevention of hepatocyte cell death. (2008) Moshage, A. J. Journal Articles Abildayeva, K., Berbee, J. F. P., Blokland, A., Jansen, P. J., Hoek, F. J., Meijer, O., Lutjohann, D., Gautier, T., Pillot, T., de Vente, J., Havekes, L. M., Ramaekers, F. C. S., Kuipers, F., Rensen, P. C. N., Mulder, M. Human apolipoprotein C-I expression in mice impairs learning and memory functions. Journal of Lipid Research 49(4): , Akoto, L., Vreuls, R. J. J., Irth, H., Pel, R., Stellaard, F. Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatographymass spectrometry. Journal of Chromatography A 1186(1-2): , 4-4- Akoto, L., Stellaard, F., Irth, H., Vreuls, R. J., Pel, R. Improved fatty acid detection in micro-algae and aquatic meiofauna species using a direct thermal desorption interface combined with comprehensive gas chromatography-timeof-flight mass spectrometry. Journal of Chromatography A 1186(1-2): , 4-4- Bakowsky, H., Richter, T., Kneuer, C., Hoekstra, D., Rothe, U., Bendas, G., Ehrhardt, C., Bakowsky, U. Adhesion characteristics and stability assessment of lectin-modified liposomes for site- specific drug delivery. Biochimica et Biophysica Acta-Biomembranes 1778(1): , Bandsma, R. H. J., Prinsen, B. H., Van Der Velden, M. D., Rake, J. P., Boer, T., Smit, G. P. A., Reijngoud, D. J., Kuipers, F. Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to Hyperlipidemia in glycogen storage disease type 1. Pediatric Research 63(6): , Bangma, H. R., Smit, G. P. A., Kuks, J. B. M., Grevink, R. G., Wolffenbuttel, B. H. R. Two patients with mitochondrial respiratory chain disease. Nederlands Tijdschrift voor Geneeskunde 152(42): , Bernier, A., Sentner, C., Correia, C., Theriaque, D., Shuster, J., Smit, G., Weinstein, D. Hyperlipidemia in glycogen storage disease type III: Effect of age and metabolic control. Journal of Inherited Metabolic Disease 31(6): , Blokzijl, H., van Steenpaal, A., Borght, S. V., Bok, L. I. H., Libbrecht, L., Tamminga, M., Geuken, M., Roskams, T. A. D., Dijkstra, G., Moshage, H., Jansen, P. L. M., Faber, K. N. Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease. Journal of Biological Chemistry 283(51): , Bocca, G., Stolk, R. P., Scheenstra, R., Sauer, P. J. J. Non-alcoholic fatty liver disease in children: A new complication of obesity. Nederlands Tijdschrift voor Geneeskunde 152(45): , Chacko, S. K., Sunehag, A. L., Sharma, S., Sauer, P. J. J., Haymond, M. W. Measurement of gluconeogenesis using glucose fragments and mass spectrometry after ingestion of deuterium oxide. Journal of Applied Physiology 104(4): , Conde de la Rosa, L., Vrenken, T. E., Hannivoort, R. A., Buist-Homan, M., Havinga, R., Slebos, D. J., Kauffman, H. F., Faber, K. N., Jansen, P. L. A., Moshage, H. Carbon monoxide blocks oxidative stressinduced hepatocyte apoptosis via inhibition of the p54 JNK isoform. Free Radical Biology and Medicine 44(7): , Conde de la Rosa, L., Moshage, H., Nieto, N. Hepatocyte oxidant stress and alcoholic liver disease. Revista Espanola de Enfermedades Digestivas 100(3): , Correia, C. E., Bhattacharya, K., Lee, P. J., Shuster, J. J., Theriaque, D. W., Shankar, M. N., Smit, G. P. A., Weinstein, D. A. Use of modified cornstarch therapy to extend fasting in glycogen storage disease types Ia and Ib. American Journal of Clinical Nutrition 88(5): , Curfs, D. M. J., Ghesquiere, S. A. I., Vergouwe, M. N., van der Made, I., Gijbels, M. J. J., Greaves, D. R., Verbeek, J. S., Hofker, M. H., de Winther, M. P. J. Macrophage secretory phospholipase A(2) group X enhances anti-inflammatory responses, promotes lipid

25 accumulation, and contributes to aberrant lung pathology. Journal of Biological Chemistry 283(31): , den Bosch, H. M. D., de Wit, N. J. W., Hooiveld, G. J. E. J., Vermeulen, H., van der Veen, J. N., Houten, S. M., Kuipers, F., Muller, M., van der Meer, R. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. American Journal of Physiology- Gastrointestinal and Liver Physiology 294(5): G1171-G1180, Derks, T. G. J., van Dijk, T. H., Grefhorst, A., Rake, J. P., Smit, G. P. A., Kuipers, F., Reijngoud, D. J. Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice. Hepatology 47(3): , Derks, T. G. J., Boer, T. S., van Assen, A., Bos, T., Ruiter, J., Waterham, H. R., Niezen-Koning, K. E., Wanders, R. J. A., Rondeel, J. A. M., Loeber, J. G., ten Kate, L. P., Smit, G. P. A., Reijngoud, D. J. Neonatal screening for medium-chain acyl- CoA dehydrogenase (MCAD) deficiency in The Netherlands: The importance of enzyme analysis to ascertain true MCAD deficiency. Journal of Inherited Metabolic Disease 31(1): 88-96, Duez, H., van der Veen, J. N., Duhem, C., Pourcet, B., Touvier, T., Fontaine, C., Derudas, B., Bauge, E., Havinga, R., Bloks, V. W., Wolters, H., van der Sluijs, F. H., Vennstrom, B., Kuipers, F., Staels, B. Regulation of bile acid synthesis by the nuclear receptor Rev-erb alpha. Gastroenterology 135(2): , Farquhar, M. J., Harris, H. J., Diskar, M., Jones, S., Mee, C. J., Nielsen, S. U., Brimacombe, C. L., Molina, S., Toms, G. L., Maurel, P., Howl, J., Herberg, F. W., van IJzendoorn, S. C. D., Balfe, P., McKeating, J. A. Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. Journal of Virology 82(17): , Giepmans, B. N. G. Bridging fluorescence microscopy and electron microscopy. Histochemistry and Cell Biology 130(2): , Goorhuis, J. F., Verkade, H. J., Brouwer, O. F. Acute hepatic injury in a child with Dravet syndrome: No protective effect of stiripentol. Seizure-European Journal of Epilepsy 17(5): , Gorter, K., van Bruggen, R., Stolk, R., Zuithoff, P., Verhoeven, R., Rutten, G. Overall quality of diabetes care in a defined geographic region: different sides of the same story. British Journal of General Practice 58(550): , Hannivoort, R. A., Dunning, S., Borght, S. V., Schroyen, B., Woudenberg, J., Oakley, F., Buist-Homan, M., van den Heuvel, F. A. J., Geuken, M., Geerts, A., Roskams, T., Faber, K. N., Moshage, H. Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology 48(2): , He, T., Venema, K., Priebe, M. G., Welling, G. W., Brummer, R. J. M., Vonk, R. J. The role of colonic metabolism in lactose intolerance. European Journal of Clinical Investigation 38(8): , Herrema, H., Derks, T. G. J., van Dijk, T. H., Bloks, V. W., Gerding, A., Havinga, R., Tietge, U. J. F., Muller, M., Smit, G. P. A., Kuipers, F., Reijngoud, D. J. Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-coa dehydrogenase (MCAD)-deficient mice. Hepatology 47(6): , Hulzebos, C. V., van Imhoff, D. E., Bos, A. F., Ahlfors, C. E., Verkade, H. J., Dijk, P. H. Usefulness of the bilirubin/albumin ratio for predicting bilirubin-induced neurotoxicity in premature infants. Archives of Disease in Childhood-Fetal and Neonatal Edition 93(5): F384-F388, Ito, K., Hoekstra, D., van IJzendoorn, S. C. D. Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2. Febs Letters 582(30): , Janssen, P. G. H., Gorter, K. J., Stolk, R. P., Rutten, G. E. H. M. Do characteristics of practices and general practitioners influence the yield of diabetes screening in primary care? The ADDITION Netherlands study. Scandinavian Journal of Primary Health Care 26(3): , Janssen, P. G. H., Gorter, K. J., Stolk, R. P., Akarsubasi, M., Rutten, G. E. H. M. Three years follow-up of screen-detected diabetic and nondiabetic subjects: who is better off? The ADDITION Netherlands study. BMC Family Practice 9 AR 67 DI / Kruit, J. K., Drayer, A. L., Bloks, V. W., Blom, N., Olthof, S. G., Sauer, P. J. J., de Haan, G., Kema, I. P., Vellenga, E., Kuipers, F. Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia. Journal of Biological Chemistry 283(10): , Kuipers, F., Groen, A. K. Chipping away at gallstones. Nature Medicine 14(7): , L'Abee, C., Sauer, P. J. J., Damen, M., Rake, J. P., Cats, H., Stolk, R. P. Cohort Profile: The GECKO Drenthe study, overweight programming during early childhood. International Journal of Epidemiology 37(3): , Liem, E. T., Sauer, P. J. J., Oldehinkel, A. J., Stolk, R. P. Association between depressive symptoms in childhood and adolescence and overweight in later life. Archives of Pediatrics & Adolescent Medicine 162(10): , Liu, Y., Havinga, R., van der Leij, F. R., Boverhof, R., Sauer, P. J. J., Kuipers, F., Stellaard, F. Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics. Pediatric Research 63(4): , Lu, Y. C., Dolle, M. E. T., Imholz, S., van't Slot, R., Verschuren, W. M. M., Wijmenga, C., Feskens, E. J. M., Boer, J. M. A. Multiple genetic GUIDE Annual Publication Report

26 variants along candidate pathways influence plasma highdensity lipoprotein cholesterol concentrations. Journal of Lipid Research 49(12): , Lukovac, S., Los, E. L., Stellaard, F., Rings, E. H. H. M., Verkade, H. J. Essential fatty acid deficiency in mice impairs lactose digestion. American Journal of Physiology-Gastrointestinal and Liver Physiology 295(3): G605-G613, Mantel, H. T. J., Verdonk, R. C., van Dullemen, H. M., Gietema, J. A., Slooff, M. J. H., Porte, R. J. Diagnosis and treatment of cholangiocarcinoma [4]. Nederlands Tijdschrift voor Geneeskunde 152(32): , Mantel, H. T. J., Verdonk, R. C., van Dullemen, H. M., Gietema, J. A., Slooff, M. J. H., Porte, R. J. Diagnostics and treatment of cholangiocarcinoma. Nederlands Tijdschrift voor Geneeskunde 152(18): , Martens, D. H. J., Rake, J. P., Schwarz, M., Ullrich, K., Weinstein, D. A., Merkel, M., Sauer, P. J. J., Smit, G. P. A. Pregnancies in glycogen storage disease type Ia. American Journal of Obstetrics and Gynecology 198(6 AR 646.e1 DI /j.ajog ): 646, Meex, S. J. R., van Vliet-Ostaptchouk, J. V., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schalkwijk, C. G., Feskens, E. J. M., Blaak, E. E., Wijmenga, C., Hofker, M. H., Stehouwer, C. D. A., de Bruin, T. W. A. Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians. Molecular Genetics and Metabolism 94(3): , Meijer, L., Weiss, J., Van Velzen, M., Brouwer, A., Bergman, A., Sauerf, P. J. J. Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in the Netherlands. Environmental Science & Technology 42(9): , Oosterveer, M. H., van Dijk, T. H., Grefhorst, A., Bloks, V. W., Havinga, R., Kuipers, F., Reijngoud, D. J. Lxr alpha deficiency hampers the hepatic adaptive response to fasting in mice. Journal of Biological Chemistry 283(37): , Petersen, C., Harder, D., Abola, Z., Alberti, D., Becker, T., Chardot, C., Davenport, M., Deutschmann, A., Khelif, K., Kobayashi, H., Kvist, N., Leonhardt, J., Melter, M., Pakarinen, M., Pawlowska, J., Petersons, A., Pfister, E. D., Rygl, M., Schreiber, R., Sokol, R., Ure, B., Veiga, C., Verkade, H., Wildhaber, B., Yerushalmi, B., Kelly, D. European biliary atresia registries: Summary of a symposium. European Journal of Pediatric Surgery 18(2): , Priebe, M. G., Wachters-Hagedoorn, R. E., Heimweg, J. A. J., Small, A., Preston, T., Elzinga, H., Stellaard, F., Vonk, R. J. An explorative study of in vivo digestive starch characteristics and postprandial glucose kinetics of wholemeal wheat bread. European Journal of Nutrition 47(8): , Priebe, M. G., van Binsbergen, J. J., De Vos, R., Vonk, R. J. Whole grain foods for the prevention of type 2 diabetes mellitus. Cochrane Database of Systematic Reviews (1 AR CD DI / CD pub2) Sandbaek, A., Griffin, S. J., Rutten, G., Davies, M., Stolk, R., Khunti, K., Borch-Johnsen, K., Wareham, N. J., Lauritzen, T. Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study. Diabetologia 51(7): , Scheenstra, R., Gerver, W. J., Odink, R. J., van Soest, H., Peelers, P. M. J. G., Verkade, H. J., Sauer, P. J. J. Growth and final height after liver transplantation during childhood. Journal of Pediatric Gastroenterology and Nutrition 47(2): , Schellekens, R. C. A., Stellaard, F., Mitrovic, D., Stuurman, F. E., Kosterink, J. G. W., Frijlink, H. W. Pulsatile drug delivery to ileocolonic segments by structured incorporation of disintegrants in ph-responsive polymer coatings. Journal of Controlled Release 132(2): 91-98, Schmidt, H. H. J., Tietge, U. J. F., Buettner, J., Barg-Hock, H., Offner, G., Schweitzer, S., Dedoussis, G. V., Rodeck, B., Kallfelz, H. C., Schlitt, H. J., Oldhafer, K., Klempnauer, J. Liver transplantation in a subject with familial hypercholesterolemia carrying the homozygous p.w577r LDL-receptor gene mutation. Clinical Transplantation 22(2): , Schneeberger, C., Stolk, R. P., DeVries, J. H., Schneeberger, P. M., Herings, R. M., Geerlings, S. E. Differences in the pattern of antibiotic prescription profile and recurrence rate for possible urinary tract infections in women with and without diabetes. Diabetes Care 31(7): , Schoemaker, M. H., Rots, M. G., Beljaars, L., Ypma, A. Y., Jansen, P. L. M., Poelstra, K., Moshage, H., Haisma, H. J. PDGF-receptor betatargeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics 5(3): , Selgrad, M., Koornstra, J. J., Fini, L., Blom, M., Huang, R., DeVol, E. B., Boersma-van Ek, W., Dijkstra, G., Verdonk, R. C., de Jong, S., Goel, A., Williams, S. L., Meyer, R. L., Haagsma, E. B., Ricciardiello, L., Boland, C. R. JC Virus Infection in Colorectal Neoplasia That Develops after Liver Transplantation. Clinical Cancer Research 14(20): , Sijens, P. E., Alkefaji, H., Lunsing, R. J., van Spronsen, F. J., Meiners, L. C., Oudkerk, M., Verkade, H. J. Quantitative multivoxel H-1 MR spectroscopy of the brain in children with acute liver failure. European Radiology 18(11): , Snieder, H., Wang, X., Shiri-Sverdlov, R., van Vliet-Ostaptchouk, J. V., Hofker, M. H., Perks, U., Spector, T. D., O'Dell, S. D. TUB is a candidate gene for late-onset obesity in women. Diabetologia 51(1): 54-61, Stolk, R. P., van Schooneveld, M. J., Cruickshank, J. K., Hughes, A. D., Stanton, A., Lu, J. M., Patel, A., Thom, S. A. M., Grobbee, D. E., Vingerling, J. R. Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes - Baseline results from the ADVANCE Retinal Measurements (AdRem) study. Diabetes Care 31(4): , GUIDE Annual Publication Report

27 Stolk, R. P., Rosmalen, J. G. M., Postma, D. S., de Boer, R. A., Navis, G., Slaets, J. P. J., Ormel, J., Wolffenbuttel, B. H. R. Universal risk factors for multifactorial diseases - LifeLines: a three-generation population-based study. European Journal of Epidemiology 23(1): 67-74, Strautnieks, S. S., Byrne, J. A., Pawlikowska, L., Cebecauerova, D., Rayner, A., Dutton, L., Meier, Y., Antoniou, A., Stieger, B., Arnell, H., Ozcay, F., Al-Hussaini, H. F., Bassas, A. F., Verkade, H. J., Fischler, B., Nemeth, A., Kotalova, R., Shneider, B. L., Cielecka-Kuszyk, J., McClean, P., Whitington, P. F., Sokal, E., Jirsa, M., Wali, S. H., Jankowska, I., Pawlowska, J., Mieli- Vergani, G., Knisely, A. S., Bull, L. N., Thompson, R. J. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology 134(4): , Tancevski, I., Wehinger, A., Demetz, E., Eller, P., Duwensee, K., Huber, J., Hochegger, K., Schgoer, W., Fievet, C., Stellaard, F., Rudling, M., Patsch, J. R., Ritsch, A. Reduced plasma highdensity lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5 '- triphosphate-binding cassette transporter 1 expression. Endocrinology 149(7): , Theard, D., Raspe, M. A., Kalicharan, D., Hoekstra, D., van IJzendoorn, S. C. D. Formation of E-cadherin/beta-cateninbased adherens junctions in hepatocytes requires serine-10 in p27(kip1). Molecular Biology of the Cell 19(4): , Tietge, U. J. F., Niistad, N., Havinga, R., Baller, J. F. W., van der Sluijs, F. H., Bloks, V. W., Gautier, T., Kuipers, F. Secretory phospholipase A(2) increases SR-B1-mediated selective uptake from HDL but not biliary cholesterol secretion. Journal of Lipid Research 49(3): , Tolle, M., Pawlak, A., Schuchardt, M., Kawamura, A., Tietge, U. J., Lorkowski, S., Keul, P., Assmann, G., Chun, J., Levkau, B., van der Giet, M., Nofer, J. R. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Arteriosclerosis Thrombosis and Vascular Biology 28(8): , van Bruggen, R., Gorter, K. J., Stolk, R. P., Verhoeven, R. P., Rutten, G. E. H. M. Implementation of locally adapted guidelines on type 2 diabetes. Family Practice 25(6): , van der Velde, A. E., Vrins, C. L. J., van den Oever, K., Seemann, I., Elferink, R. P. J. O., van Eck, M., Kuipers, F., Groen, A. K. Regulation of direct transintestinal cholesterol excretion in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 295(1): G203-G208, van Hasselt, P. M., de Koning, T. J., Kvist, N., de Vries, E., Lundin, C. R., Berger, R., Kimpen, J. L. L., Houwen, R. H. J., Jorgensen, M. H., Verkade, H. J. Prevention of vitamin K deficiency bleeding in breastfed infants: Lessons from the Dutch and Danish biliary atresia registries. Pediatrics 121(4): E857-E863, van Meer, H., Boehm, G., Stellaard, F., Vriesema, A., Knol, J., Havinga, R., Sauer, P. J., Verkade, H. J. Prebiotic oligosaccharides and the enterohepatic circulation of bile salts in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 294(2): G540- G547, van Straten, E. M. E., Huijkman, N. C. A., Baller, J. F. W., Kuipers, F., Plosch, T. Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism. American Journal of Physiology-Endocrinology and Metabolism 295(6): E1341-E1348, van Vliet-Ostaptchouk, J. V., Onland-Moret, N. C., van Haeften, T. W., Franke, L., Elbers, C. C., Shiri-Sverdlov, R., van der Schouw, Y. T., Hofker, M. H., Wijmenga, C. HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics 16(5): , Vanschoonbeek, K., Wouters, K., van der Meijden, P. E. J., van Gorp, P. J., Feijge, M. A. H., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P. M., Heemskerk, J. W. M. Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia A Study of Hepatic Gene Expression in APOE2 Knock-in Mice. Arteriosclerosis Thrombosis and Vascular Biology 28(11): , Verhagen, A. A. E., Sauer, P. J. "Are their babies different from ours?" Dutch culture and the Groningen Protocol. Hasting Center Report 38(4): 4, Vonk, W. I. M., Wijmenga, C., van de Sluis, B. Relevance of animal models for understanding mammalian copper homeostasis. American Journal of Clinical Nutrition 88(3): 840S-845S, Voorham, J., Haaijer-Rustcamp, F. M., Stolk, R. P., Wolffenbuttel, B. H. R., Denig, P. Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes. Diabetes Care 31(3): , Vrenken, T. E., Buist-Homan, M., Kalsbeek, A. J., Faber, K. N., Moshage, H. The active metabolite of leflunomide, A , protects rat hepatocytes against bile acid-induced apoptosis. Journal of Hepatology 49(5): , Wang, H., Weening, D., Jonkers, E., Boer, T., Stellaard, F., Small, A. C., Preston, T., Vonk, R. J., Priebe, M. G. A curve fitting approach to estimate the extent of fermentation of indigestible carbohydrates. European Journal of Clinical Investigation 38(11): , Wieringa, N. F., van der Windt, H. J., Zuiker, R. R. M., Dijkhuizen, L., Verkerk, M. A., Vonk, R. J., Swart, J. A. A. Positioning functional foods in an ecological approach to the prevention of overweight and obesity. Obesity Reviews 9(5): , Wojtal, K. A., Hoekstra, D., van IJzendoorn, S. C. D. camp-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape. Bioessays 30(2): , Wouters, K., van Gorp, P. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lutjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., van Bilsen, M., Shiri-Sverdlov, R., Hofker, M. H. Dietary cholesterol, GUIDE Annual Publication Report

28 rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48(2): , Research Line Intestinal function, mucosal immunity and inflammation Dissertations Los, E. L. Intestinal function in cholestasis and essential fatty acid deficiency. (2007) Verkade, H. J. and Rings, E. H. H. M. Ma, Y. Classical Hodgkin lymphoma: investigation of the cross-talk between the HRS cells and the reactive lymphocytes. (2007) Poppema, S. and Vonk, R. J. Stellinga-Boelen, A. A. M. Nutritional assessment of asylumseekers' children in The Netherlands. (2007) Verkade, H. J. and Bijleveld, C. M. A. Weersma, R. K. Genetic susceptibility for inflammatory bowel diseases. (2007) Kleibeuker, J. H. and Wijmenga, C. Journal Articles Bauer, F., Onland-Moret, N. C., Niehoff, A. G., Elbers, C. C., Grobbee, D. E., Wijmenga, C., van der Schouw, Y. T. No Association of PTPN1 Polymorphisms With Macronutrient Intake and Measures of Adiposity. Obesity 16(12): , Bilguvar, K., Yasuno, K., Niemela, M., Ruigrok, Y. M., Fraunberg, M. V. Z., van Duijn, C. M., van den Berg, L. H., Mane, S., Mason, C. E., Choi, M., Gaal, E., Bayri, Y., Kolb, L., Arlier, Z., Ravuri, S., Ronkainen, A., Tajima, A., Laakso, A., Hata, A., Kasuya, H., Koivisto, T., Rinne, J., Ohman, J., Breteler, M. M. B., Wijmenga, C., State, M. W., Rinkel, G. J. E., Hernesniemi, J., Jaaskelainen, J. E., Palotie, A., Inoue, I., Lifton, R. P., Gunel, M. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nature Genetics 40(12): , Blokzijl, H., van Steenpaal, A., Borght, S. V., Bok, L. I. H., Libbrecht, L., Tamminga, M., Geuken, M., Roskams, T. A. D., Dijkstra, G., Moshage, H., Jansen, P. L. M., Faber, K. N. Upregulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease. Journal of Biological Chemistry 283(51): , Buiter, H. D., Dijkstra, S. S. P., Elferink, R. F. M. O., Bijster, P., Woltil, H. A., Verkade, H. J. Neonatal jaundice and stool production in breast- or formula-fed term infants. European Journal of Pediatrics 167(5): , de Ridder, L., Rings, E. H. H. M., Damen, G. M., Kneepkens, C. M. F., Schweizer, J. J., Kokke, F. T. M., Benninga, M. A., Norbruis, O. F., Hoekstra, J. H., Gijsbers, C. F. M., Escher, J. C. Infliximab dependency in pediatric Crohn's disease: Long-term follow-up of an unselected cohort. Inflammatory Bowel Diseases 14(3): , Esser, D., varez-llamas, G., de Vries, M., Weening, D., Vonk, R. J., Roelofsen, H. Sample stability and protein composition of saliva: Implications for its use as a diagnostic fluid. Biomarker Insights 2008(3): 25-37, Festen, E. A., Zhernakova, A., Wijmenga, C., Weersma, R. K. Association of DLG5 variants with gluten-sensitive enteropathy. Gut 57(7): , Franke, A., Balschun, T., Karlsen, T. H., Sventoraityte, J., Nikolaus, S., Mayr, G., Domingues, F. S., Albrecht, M., Nothnagel, M., Ellinghaus, D., Sina, C., Onnie, C. M., Weersma, R. K., Stokkers, P. C. F., Wijmenga, C., Gazouli, M., Strachan, D., McArdle, W. L., Vermeire, S., Rutgeerts, P., Rosenstiel, P., Krawczak, M., Vatn, M. H., Mathew, C. G., Schreiber, S. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nature Genetics 40(11): , Franke, L., de Kovel, C. G. E., Aulchenko, Y. S., Trynka, G., Zhernakova, A., Hunt, K. A., Blauw, H. M., van den Berg, L. H., Ophoff, R., Deloukas, P., van Heel, D. A., Wijmenga, C. Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. American Journal of Human Genetics 82(6): , Geremek, M., Schoenmaker, F., Zietkiewicz, E., Pogorzelski, A., Diehl, S., Wijmenga, C., Witt, M. Sequence analysis of 21 genes located in the Kartagener syndrome linkage region on chromosome 15q. European Journal of Human Genetics 16(6): , He, T., Priebe, M. G., Zhong, Y., Huang, C., Harmsen, H. J. M., Raangs, G. C., Antoine, J. M., Welling, G. W., Vonk, R. J. Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. Journal of Applied Microbiology 104(2): , He, T., Venema, K., Priebe, M. G., Welling, G. W., Brummer, R. J. M., Vonk, R. J. The role of colonic metabolism in lactose intolerance. European Journal of Clinical Investigation 38(8): , Hunt, K. A., Zhernakova, A., Turner, G., Heap, G. A. R., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., Gwilliam, R., Takeuchi, F., McLaren, W. M., Holmes, G. K. T., Howdle, P. D., Walters, J. R. F., Sanders, D. S., Playford, R. J., Trynka, G., Mulder, C. J. J., Mearin, M. L., Verbeek, W. H. M., Trimble, V., Stevens, F. M., O'Morain, C., Kennedy, N. P., Kelleher, D., Pennington, D. J., Strachan, D. P., McArdle, W. L., Mein, C. A., Wapenaar, M. C., Deloukas, P., McGinnis, R., McManus, R., Wijmenga, C., van Heel, D. A. Newly identified genetic risk variants for celiac disease related to the immune response. Nature Genetics 40(4): , Hunt, K. A., Franke, L., Deloukas, P., Wjmenga, C., van Heel, D. A. No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. Gastroenterology 134(5): , Jungerius, B. J., Bakker, S. C., Monsuur, A. J., Sinke, R. J., Kahn, R. S., Wijmenga, C. Is MYO9B the missing link between schizophrenia GUIDE Annual Publication Report

29 and celiac disease? American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 147B(3): , Koskinen, L. L. E., Korponay-Szabo, I. R., Viiri, K., Juuti-Uusitalo, K., Kaukinen, K., Lindfors, K., Mustalahti, K., Kurppa, K., Adany, R., Pocsai, Z., Szeles, G., Einarsdottir, E., Wijmenga, C., Maki, M., Partanen, J., Kere, J., Saavalainen, P. Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. Journal of Medical Genetics 45(4): , van Meer, H., Boehm, G., Stellaard, F., Vriesema, A., Knol, J., Havinga, R., Sauer, P. J., Verkade, H. J. Prebiotic oligosaccharides and the enterohepatic circulation of bile salts in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 294(2): G540- G547, Wang, H., Weening, D., Jonkers, E., Boer, T., Stellaard, F., Small, A. C., Preston, T., Vonk, R. J., Priebe, M. G. A curve fitting approach to estimate the extent of fermentation of indigestible carbohydrates. European Journal of Clinical Investigation 38(11): , Lukovac, S., Los, E. L., Stellaard, F., Rings, E. H. H. M., Verkade, H. J. Essential fatty acid deficiency in mice impairs lactose digestion. American Journal of Physiology-Gastrointestinal and Liver Physiology 295(3): G605-G613, Lutgens, M. W. M. D., Vleggaar, F. P., Schipper, M. E. I., Stokkers, P. C. F., van der Woude, C. J., Hommes, D. W., de Jong, D. J., Dijkstra, G., van Bodegraven, A. A., Oldenburg, B., Samsom, M. High frequency of early colorectal cancer in inflammatory bowel disease. Gut 57(9): , Omloo, J. M. T., Sloof, G. W., Boellaard, R., Hoekstra, O. S., Jager, P. L., van Dullemen, H. M., Fockens, P., Plukker, J. T. M., van Lanschot, J. J. B. Importance of fluorodeoxyglucosepositron emission tomography (FDG-PET) and endoscopic ultrasonography parameters in predicting survival following surgery for esophageal cancer. Endoscopy 40(6): , Pultrum, B. B., van Bastelaar, J., Schreurs, L. M. A., van Dullemen, H. M., Groen, H., Nijsten, M. W. N., van Dam, G. M., Plukker, J. T. H. M. Impact of splenectomy on surgical outcome in patients with cancer of the distal esophagus and gastro-esophageal junction. Diseases of the Esophagus 21(4): , Romanos, J., Rybak, A., Wijmenga, C., Wapenaar, M. C. Molecular diagnosis of celiac disease: Are we there yet? Expert Opinion on Medical Diagnostics 2(4): , Wapenaar, M. C., Monsuur, A. J., van Bodegraven, A. A., Weersma, R. K., Bevova, M. R., Linskens, R. K., Howdle, P., Holmes, G., Mulder, C. J., Dijkstra, G., van Heel, D. A., Wijmenga, C. Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut 57(4): , Weersma, R. K., Batstra, M. R., Kleibeuker, J. H., van Dullemen, H. M. Are pancreatic autoantibodies associated with azathioprineinduced pancreatitis in Crohn's disease? Journal of the Pancreas 9(3): , Weersma, R. K., Zhernakova, A., Nolte, I. M., Lefebvre, C., Rioux, J. D., Mulder, F., van Dullemen, H. M., Kleibeuker, J. H., Wijmenga, C., Dijkstra, G. ATG16L1 and IL23R Are Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands. American Journal of Gastroenterology 103(3): , Weersma, R. K., Zhou, L., Nolte, I. M., van der Steege, G., van Dullemen, H. M., Oosterom, E., Bok, L., Peppelenbosch, M. P., Faber, K. N., Kleibeuker, J. H., Dijkstra, G. Runt-Related Transcription Factor 3 Is Associated with Ulcerative Colitis and Shows Epistasis with Solute Carrier Family 22, Members 4 and 5. Inflammatory Bowel Diseases 14(12): , Wolters, V. M., Wijmenga, C. Genetic background of celiac disease and its clinical implications. American Journal of Gastroenterology 103(1): , Yuvaraj, S., Lahham, S., Marreddy, R. K. R., Dijkstra, G., Wolken, W. A. M., Lolkema, J. S., Helfrich, W., Johansen, F. E., Peppelenbosch, M. P., Bos, N. A. Human scfv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease. Molecular Nutrition & Food Research 52(8): , Selgrad, M., Koornstra, J. J., Fini, L., Blom, M., Huang, R., DeVol, E. B., Boersma-van Ek, W., Dijkstra, G., Verdonk, R. C., de Jong, S., Goel, A., Williams, S. L., Meyer, R. L., Haagsma, E. B., Ricciardiello, L., Boland, C. R. JC Virus Infection in Colorectal Neoplasia That Develops after Liver Transplantation. Clinical Cancer Research 14(20): , Zhernakova, A., Festen, E. M., Franke, L., Trynka, G., van Diemen, C. Smyth, D. J., Plagnol, V., Walker, N. M., Cooper, J. D., Downes, K., Yang, J. H. M., Howson, J. M. M., Stevens, H., McManus, R., Wijmenga, C., Heap, G. A., Dubois, P. C., Clayton, D. G., Hunt, K. A., van Heel, D. A., Todd, J. A. Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease. New England Journal of Medicine 359(26): , van Hasselt, P. M., de Koning, T. J., Kvist, N., de Vries, E., Lundin, C. R., Berger, R., Kimpen, J. L. L., Houwen, R. H. J., Jorgensen, M. H., Verkade, H. J. Prevention of vitamin K deficiency bleeding in breastfed infants: Lessons from the Dutch and Danish biliary atresia registries. Pediatrics 121(4): E857-E863, C., Monsuur, A. J., Bevova, M., Nijmeijer, R. M., van't Slot, R., Heijmans, R., Boezen, H. M., van Heel, D. A., van Bodegraven, A. A., Stokkers, P. C. F., Wijmenga, C., Crusius, J. B. A., Weersma, R. K. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. American Journal of Human Genetics 82(5): , GUIDE Annual Publication Report

30 INSTITUTE FOR TRANSPLANTATION, IMMUNOLOGY AND INFLAMMATION - TRIO Research Line Transplantation Dissertations Buis, C. I. Molecular and biochemical mechanisms of bile duct injury after liver transplantation. (2008) Porte, R. J. Maathuis, M. H. J. Organ preservation and viability in kidney and liver transplantation. (2008) Ploeg, R. J., Rakhorst, G., and Leuvenink, H. G. D. Polak, W. G. Technical aspects of liver transplantation. (2008) Slooff, M. J. H., Porte, R. J., Peeters, P. M. J. G., and de Jong, K. P. Song, Hui. Cold preservation injury in organ transplantation: beneficial effects of dopamine and carbon monoxide releasing molecules. (2008) Yard, B. and Ploeg, R. J. Journal Articles Bakker, N. A., van Dijk, J. M. C., Slart, R. H. J. A., Coppes, M. H., van Imhoff, G. W., Verschuuren, E. A. M. Extradural thoracic spinal cord compression: Unusual initial presentation of posttransplant lymphoproliferative disorder. Journal of Heart and Lung Transplantation 27(10): , Bakker, N. A., van Imhoff, G. W., van Son, W. J., Kluin, Ph, Kluin- Nelemans, J. C., Verschuuren, E. A. M. Lymphoma in patients who have undergone organ transplantation: Severe and variable clinical presentation. Nederlands Tijdschrift voor Geneeskunde 152(19): , Bakker, N. A., Verschuuren, E. A., Veeger, N. J., van der Bij, W., van Imhoff, G. W., Kallenberg, C. G., Hepkema, B. G. Quantification of Epstein-Barr virus-dna load in lung transplant recipients: A comparison of plasma versus whole blood. Journal of Heart and Lung Transplantation 27(1): 7-10, Besselink, M. G. H., van Santvoort, H. C., Buskens, E., Boermeester, M. A., van Goor, H., Timmerman, H. M., Nieuwenhuijs, V. B., Bollen, T. L., van Ramshorst, B., Witteman, B. J. M., Rosman, C., Ploeg, R. J., Brink, M. A., Schaapherder, A. F. M., Dejong, C. H. C., Wahab, P. J., van Laarhoven, C. J. H. M., van der Harst, E., Van Eijck, C. H. J., Cuesta, M. A., Akkermans, L. M. A., Gooszen, H. G. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 371(9613): , Borg, M. A. J. P., van der Wouden, E. J., Sluiter, W. J., Slooff, M. J. H., Haagsma, E. B., van den Berg, A. P. Vascular events after liver transplantation: a long-term follow-up study. Transplant International 21(1): 74-80, Buis, C. I., van der Steege, G., Visser, D. S., Nolte, I. M., Hepkema, B. G., Nijsten, M., Slooff, M. J. H., Porte, R. J. Heme oxygenase-1 genotype of the donor is associated with graft survival after liver transplantation. American Journal of Transplantation 8(2): , Damman, J., Schuurs, T. A., Ploeg, R. J., Seelen, M. A. Complement and renal transplantation: From donor to recipient. Transplantation 85(7): , de Boer, M. T., Christensen, M. C., Asmussen, M., van der Hilst, C. S., Hendriks, H. G. D., Slooff, M. J. H., Porte, R. J. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesthesia and Analgesia 106(1): 32-44, de Jong, K. P. Radiofrequency ablation: A worthy addition to the spectrum of therapies for liver tumours. Nederlands Tijdschrift voor Geneeskunde 152(15): , Drent, G., Moons, P., de Geest, S., Kleibeuker, J. H., Haagsma, E. B. Symptom experience associated with immunosuppressive drugs after liver transplantation in adults: possible relationship with medication noncompliance? Clinical Transplantation 22(6): , Duan, L., de Vos, P., Fan, M., Ren, Y. Notch is activated in RANKL-induced osteoclast differentiation and resorption. Frontiers in Bioscience 13: , Durand, F., Renz, J. F., Alkofer, B., Burra, P., Clavien, P. A., Porte, R. J., Freeman, R. B., Belghiti, J. Report of the Paris Consensus Meeting on Expanded Criteria Donors in Liver Transplantation. Liver Transplantation 14(12): , Engelsman, A. F., van der Mei, H. C., Busscher, H. J., Ploeg, R. J. Morphological aspects of surgical meshes as a risk factor for bacterial colonization. British Journal of Surgery 95(8): , Fraser, I. S., Porte, R. J., Kouides, P. A., Lukes, A. S. A benefitrisk review of systemic haemostatic agents - Part 1: In major surgery. Drug Safety 31(3): , Fraser, I. S., Porte, R. J., Kouides, P. A., Lukes, A. S. A benefitrisk review of systemic halemostatic agents - Part 2: In excessive or heavy menstrual bleeding. Drug Safety 31(4): , Groenewegen, H. C., Onuta, G., Goris, M., Zandvoort, A., Zijlstra, F., van Gilst, W. H., Rozing, J., de Smet, B. J. G. L., Roks, A. J. M., Hillebrands, J. L. Non-Bone Marrow Origin of Neointimal Smooth Muscle Cells in Experimental In-Stent Restenosis in Rats. Journal of Vascular Research 45(6): ,

31 Haagsma, E. B., van den Berg, A. P., Porte, R. J., Benne, C. A., Vennema, H., Reimerink, J. H. J., Koopmans, M. P. G. Chronic hepatitis E virus infection in liver transplant recipients. Liver Transplantation 14(4): , Hanusch, C., Nowak, K., Torlitz, P., Gill, I. S., Song, H., Rafat, N., Brinkkoetter, P. T., Leuvenink, H. G., Van Ackern, K. C., Yard, B. A., Beck, G. C. Donor dopamine treatment limits pulmonary oedema and inflammation in lung allografts subjected to prolonged hypothermia. Transplantation 85(10): , Heyligers, J. M. M., Lisman, T., Verhagen, H. J. M., Weeterings, C., de Groot, P. G., Moll, F. L. A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopeniaassociated antibodies in humans. Journal of Vascular Surgery 47(2): , Hoeger, S., Reisenbuechler, A., Gottmann, U., Doyon, F., Braun, C., Kaya, Z., Seelen, M. A., van Son, W. J., Waldherr, R., Schnuelle, P., Yard, B. A. Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation. Transplant International 21(11): , Hoekstra, H., Tian, Y., Jochum, W., Stieger, B., Graf, R., Porte, R. J., Clavien, P. A. Dearterialization of the liver causes intrahepatic cholestasis due to reduced bile transporter expression. Transplantation 85(8): , IJtsma, A. J. C., Boeve, L. M. S., van der Hilst, C. S., de Boer, M. T., de Jong, K. P., Peeters, P., Gouw, A. S. H., Porte, R. J., Slooff, M. J. H. The Survival Paradox of Elderly Patients After Major Liver Resections. Journal of Gastrointestinal Surgery 12(12): , Kobori, L., Nemeth, T., Nagy, P., Dallos, G., Sotonyi, P., Fehervari, I., Nemes, B., Gorog, D., Patonai, A., Monostory, K., Doros, A., Sarvary, E., Fazakas, J., Gerlei, Z., Benko, T., Piros, L., Jaray, J., de Jong, K. P. Experimental results and clinical impact of using autologous rectus fascia sheath for vascular replacement. Acta Veterinaria Hungarica 56(3): , Koudstaal, L. G., 't Hart, N. A., Ottens, P. J., van den Berg, A., Ploeg, R. J., van Goor, H., Leuvenink, H. G. D. Brain death induces inflammation in the donor intestine. Transplantation 86(1): , Krenning, G., Moonen, J. R. A. J., van Luyn, M. J. A., Harmsen, M. C. Generating New Blood Flow: Integrating Developmental Biology and Tissue Engineering. Trends in Cardiovascular Medicine 18(8): , Krenning, G., Moonen, J. R. A. J., van Luyn, M. J. A., Harmsen, M. C. Vascular smooth muscle cells for use in vascular tissue engineering obtained by endothelial-to-mesenchymal transdifferentiation (EnMT) on collagen matrices. Biomaterials 29(27): , Lijfering, W. M., de Vries, A. R. J., Veeger, N. J. G. M., van Son, W. J., Bakker, S. J. L., van der Meer, J. Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation. Thrombosis and Haemostasis 99(1): , Lisman, T., van Leeuwen, Y., Adelmeijer, J., Pereboom, I. T. A., Haagsma, E. B., van den Berg, A. P., Porte, R. J. Interlaboratory variability in assessment of the model of end-stage liver disease score. Liver International 28(10): , Maathuis, M. H. J., Moers, C., Leuvenink, H. G. D., Ploeg, R. J. A successful transplant begins with organ preservation. Nederlands Tijdschrift voor Geneeskunde 152(13): , Maathuis, M. H. J., Ottens, P. J., van Goor, H., Zwaagstra, J. J., Wiersema-Buist, J., Schuurs, T. A., Ploeg, R. J., Leuvenink, H. G. D. Static cold storage preservation of ischemically damaged kidneys. A comparison between IGL-1 and UW solution. Transplant International 21(5): , Mantel, H. T. J., Verdonk, R. C., van Dullemen, H. M., Gietema, J. A., Slooff, M. J. H., Porte, R. J. 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32 creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients. Transplantation 86(3): , Pereboom, I. T. A., Lisman, T., Porte, R. J. Platelets in liver transplantation: Friend or foe? Liver Transplantation 14(7): , Polak, W. G., Soyama, A., Slooff, M. J. H. Liver transplantation in patients with hepatocellular carcinoma. Annals of Transplantation 13(4): 5-15, Polak, W. G., Peeters, P. M. J. G., Miyamoto, S., Sieders, E., de Jong, K. P., Porte, R. J., Bijleveld, C. M. A., Hendriks, H. G., TenVergert, E. M., Slooff, M. J. H. The outcome of primary liver transplantation from deceased donors in children with body weight <= 10 kg. Clinical Transplantation 22(2): , Porte, R. J., Mallette, S. V., Burroughs, A. K. Aprotinin and lysine analogues in high-risk cardiac surgery. New England Journal of Medicine 359(11): 1181, Rook, M., Bosma, R. J., van Son, W. J., Hofker, H. S., van der Heide, J. J. H., ter Wee, P. M., Ploeg, R. 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40 Versteeg, H. H., Borensztajn, K. S., Kerver, M. E., Ruf, W., Reitsma, P. H., Spek, C. A., Peppelenbosch, M. P. TF : FVIIa-specific activation of CREB upregulates proapoptotic proteins via protease-activated receptor-2. Journal of Thrombosis and Haemostatis 6(9): , properties of immature virions. Journal of General Virology 89(12): , Visser, A., Raghoebar, G. M., van Oort, R. P., Vissink, A. Fate of implant-retained craniofacial prostheses: Life span and aftercare. International Journal of Oral & Maxillofacial Implants 23(1): 89-98, Walker, A. W., Duncan, S. H., Harmsen, H. J. M., Holtrop, G., Welling, G. W., Flint, H. J. The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environmental Microbiology 10(12): , Weersma, R. K., Zhou, L., Nolte, I. M., van der Steege, G., van Dullemen, H. M., Oosterom, E., Bok, L., Peppelenbosch, M. P., Faber, K. N., Kleibeuker, J. H., Dijkstra, G. Runt-Related Transcription Factor 3 Is Associated with Ulcerative Colitis and Shows Epistasis with Solute Carrier Family 22, Members 4 and 5. Inflammatory Bowel Diseases 14(12): , Westers, L., Westers, H., Zanen, G., Antelmann, H., Hecker, M., Noone, D., Devine, K. M., van Dijl, J. M., Quax, W. J. Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome. Proteomics 8(13): , Widdick, D. A., Eijlander, R. T., van Dijl, J. M., Kuipers, O. P., Palmer, T. A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life. Journal of Molecular Biology 375(3): , Yuvaraj, S., Lahham, S., Marreddy, R. K. R., Dijkstra, G., Wolken, W. A. M., Lolkema, J. S., Helfrich, W., Johansen, F. E., Peppelenbosch, M. P., Bos, N. A. Human scfv SIgA expressed on Lactococcus lactis as a vector for the treatment of mucosal disease. Molecular Nutrition & Food Research 52(8): , Zambuzzi, W. F., Granjeiro, J. M., Parikh, K., Yuvaraj, S., Peppelenbosch, M. P., Ferreira, C. V. Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation. Cellular Physiology and Biochemistry 22(5-6): , Zeng, W., Gouw, A. S. H., van den Heuvel, M. C., Zwiers, P. J., Zondervan, P. E., Poppema, S., Zhang, N., Platteel, I., de Jong, K. P., Molema, G. The Angiogenic Makeup of Human Hepatocellular Carcinoma Does Not Favor Vascular Endothelial Growth Factor/Angiopoletin-Driven Sprouting Neovascularization. Hepatology 48(5): , Zweers, J. C., Barak, I., Becher, D., Driessen, A. J. M., Hecker, M., Kontinen, V. P., Saller, M. J., Vavrova, L., van Dijl, J. M. Towards the development of Bacillus subtilis as a cell factory for membrane proteins and protein complexes. Microbial Cell Factories 7 AR 10 DI / Zybert, I. A., van der Ende-Metselaar, H., Wilschut, J., Smit, J. M. Functional importance of dengue virus maturation: infectious GUIDE Annual Publication Report

41 NORTHERN NETHERLANDS ONCOLOGY CENTER NNOC Research Line Cancer: genes, mutations and their consequences Dissertations Booman, M. The role of immunoediting in lymphomas of immune-privileged sites. (2008) Kluin, P. M., Schuuring, E., and de Jong, D. Bosveld, F. Physiological implications of impaired de novo coenzyme A biosynthesis in Drosophila melanogaster. (2008) Kampinga, H. H. and Sibon, O. C. M. Crijns, A. P. G. Prognostic microarray in ovarian cancer : toward patient-tailored therapy. (2008) Zee, A. G. J. van der, de Vries, E. G. E., de Jong, S., Gerbens, F., and te Meerman, G. J. Hageman, J. The human HSP70/HSP40 chaperone family : a study on its capacity to combat proteotoxic stress. (2008) Kampinga, H. H. Lombaert, I. M. A. Regeneration of irradiated salivary glands by stem cell therapy. (2008) Haan, G. de, Kampinga, H. H., and Coppes, R. P. Ou, J. Functional analysis and carrier detection of mismatch repair gene mutations. (2008) Hofstra, R. M. W., Kleibeuker, J. H., and Sijmons, R. H. Journal Articles Amiel, J., Sproat-Emison, E., Garcia-Barcelo, M., Lantieri, F., Burzynski, G., Borrego, S., Pelet, A., Arnold, S., Miao, X., Griseri, P., Brooks, A. S., Antinolo, G., de Pontual, L., Clement-Ziza, M., Munnich, A., Kashuk, C., West, K., Wong, K. K. Y., Lyonnet, S., Chakravarti, A., Tam, P. K. H., Ceccherini, I., Hofstra, R. M. W., Fernandez, R. Hirschsprung disease, associated syndromes and genetics: a review. Journal of Medical Genetics 45(1): 1-14, Beerens, A. M. J., Rots, M. G., Bermudez, B., de Vries, E. F. J., Haisma, H. J. Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity. Journal of Drug Targeting 16(1): 26-35, Booman, M., Szuhai, K., Rosenwald, A., Hartmann, E., Kluin- Nelemans, H. C., de Jong, D., Schuuring, E., Kluin, P. M. Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways. Journal of Pathology 216(2): , Bosveld, F., Rana, A., van der Wouden, P. E., Lemstra, W., Ritsema, M., Kampinga, H. H., Sibon, O. C. M. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Human Molecular Genetics 17(13): , Bosveld, F., van Hoek, S., Sibon, O. C. M. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dmed31. Developmental Biology 313(2): , Breitling, R., Li, Y., Tesson, B. M., Fu, J. Y., Wu, C. L., Wiltshire, T., Gerrits, A., Bystrykh, L. V., de Haan, G., Su, A. I., Jansen, R. C. Genetical Genomics: Spotlight on QTL Hotspots. PLoS Genetics 4(10) Couch, F. J., Rasmussen, L. J., Hofstra, R., Monteiro, A. N. A., Greenblatt, M. S., de Wind, N. Assessment of Functional Effects of Unclassified Genetic Variants. Human Mutation 29(11): , Fehrmann, R. S. N., de Jonge, H. J. M., ter Elst, A., de Vries, A., Crijns, A. G. P., Weidenaar, A. C., Gerbens, F., de Jong, S., van der Zee, A. G. J., de Vries, E. G. E., Kamps, W. A., Hofstra, R. M. W., te Meerman, G. J., de Bont, E. S. J. M. A new perspective on transcriptional system regulation (TSR): Towards TSR profiling. PLoS ONE 3(2): e1656, Greenblatt, M. S., Brody, L. C., Foulkes, W. D., Genuardi, M., Hofstra, R. M. W., Olivier, M., Plon, S. E., Sijmons, R. H., Sinilnikova, O., Spurdle, A. B. Locus-Specific Databases and Recommendations to Strengthen Their Contribution to the Classification of Variants in Cancer Susceptibility Genes. Human Mutation 29(11): , Groen, E. J., Roos, A., Muntinghe, F. L., Enting, R. H., de Vries, J., Kleibeuker, J. H., Witjes, M. J. H., Links, T. P., van Beek, A. P. Extraintestinal manifestations of familial adenomatous polyposis. Annals of Surgical Oncology 15(9): , Guikema J.E.J., Schuuring E., Kluin P.M. Structure and consequences of IGH switch breakpoints in Burkitt lymphoma. Journal of the National Cancer Institute - Monographs 39: 32-35, Haisma, H. J., Kamps, J. A. A. M., Kamps, G. K., Plantinga, J. A., Rots, M. G., Bellu, A. R. Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages. Journal of General Virology 89: , Hofstra, R. M. W., Spurdle, A. B., Eccles, D., Foulkes, W. D., de Wind, N., Hoogerbrugge, N., Hogervors, F. B. L. Tumor Characteristics as an Analytic Tool for Classifying Genetic Variants of Uncertain Clinical Significance. Human Mutation 29(11): , GUIDE Annual Publication Report

42 Holzik, M. F. L., Sijmons, R. H., Hoekstra-Weebers, J. E. H. M., Sleijfer, D. T., Hoekstra, H. J. Clinical and genetic aspects of testicular germ cell tumours. Heredity Cancer in Clinical Practice 6(1): 3-14, Hoque, M. O., Kim, M. S., Ostrow, K. L., Liu, J., Wisman, G. B. A., Park, H. L., Poeta, M. L., Jeronimo, C., Henrique, R., Lendvai, A., Schuuring, E., Begum, S., Rosenbaum, E., Ongenaert, M., Yamashita, K., Califano, J., Westra, W., van der Zee, A. G. J., van Criekinge, W., Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Research 68(8): , Koornstra, J. J., Kleibeuker, J. H., Vasen, H. F. A. Small-bowel cancer in Lynch syndrome: is it time for surveillance? Lancet Oncology 9(9): , Lombaert, I. M., Brunsting, J. F., Wierenga, P. K., Faber, H., Stokman, M. A., Kok, T., Visser, W. H., Kampinga, H. H., de Haan, G., Coppes, R. P. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE 3(4): e2063, Lombaert, I. M. A., Brunsting, J. F., Wierenga, P. K., Kampinga, H. H., de Haan, G., Coppes, R. P. Cytokine Treatment Improves Parenchymal and Vascular Damage of Salivary Glands after Irradiation. Clinical Cancer Research 14(23): , Lombaert, I. M. A., Brunsting, J. F., Wierenga, P. K., Kampinga, H. H., de Haan, G., Coppes, R. P. Keratinocyte Growth Factor Prevents Radiation Damage to Salivary Glands by Expansion of the Stem/Progenitor Pool. Stem Cells 26(10): , Niens, M., Visser, L., Nolte, I. M., van der Steege, G., Diepstra, A., Cordano, P., Jarrett, R. F., te Meerman, G. J., Poppema, S., van den Berg, A. Serum chemokine levels in Hodgkin lymphoma patients: highly increased levels of CCL17 and CCL22. British Journal of Haematology 140(5): , Ockhuysen-Vermey, C. F., Henneman, L., van Asperen, C. J., Oosterwijk, J. C., Menko, F. H., Timmermans, D. R. M. Design of the BRISC study: a multicentre controlled clinical trial to optimize the communication of breast cancer risks in genetic counselling. BMC Cancer 8 AR 283 DI / : 283, Ou, J. H., Niessen, R. C., Vonk, J., Westers, H., Hofstra, R. M. W., Sijmons, R. H. A Database to Support the Interpretation of Human Mismatch Repair Gene Variants. Human Mutation 29(11): , Pinto, M., Wub, Y., Mensink, R. G. J., Cirnes, L., Seruca, R., Hofstra, R. M. W. Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype. Cancer Genetics and Cytogenetics 180(2): , Schoemaker, M. H., Rots, M. G., Beljaars, L., Ypma, A. Y., Jansen, P. L. M., Poelstra, K., Moshage, H., Haisma, H. J. PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics 5(3): , Sijmons, R. H. Encyclopaedia of tumour-associated familial disorders. Part I: from AIMAH to CHIME syndrome. Heredity Cancer in Clinical Practice 6(1): 22-57, Stulp, R. P., Herkert, J. C., Karrenbeld, A., Mol, B., Vos, Y. J., Sijmons, R. H. Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum. Heredity Cancer in Clinical Practice 6(1): 15-21, Sugahara, T., Van der Zee, J., Kampinga, H. H., Vujaskovic, Z., Kondo, M., Ohnishi, T., Li, G., Park, H. J., Leeper, D. B., Ostapenko, V., Repasky, E. A., Watanabe, M., Song, C. W., Kampinga, H. H. Kadota Fund International Forum Application of thermal stress for the improvement of health, June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final Report. International Journal of Hyperthermia 24(2): , van der Gun, B. T. F., Wasserkort, R., Monami, A., Jeltsch, A., Rasko, T., Slaska-Kiss, K., Cortese, R., Rots, M. G., de Leij, L. F. M. H., Ruiters, M. H. J., Kiss, A., Weinhold, E., McLaughlin, P. M. J. Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. International Journal of Cancer 123(2): , van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., Nollen, E. A. A. C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genetics 4(3): e , Vos, M. J., Kampinga, H. H. A PCR amplification strategy for unrestricted generation of chimeric genes. Analytical Biochemistry 380(2): , Vos, M. J., Hageman, J., Carra, S., Kampinga, H. H. Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry 47(27): , Yi, X., Lemstra, W., Vos, M. J., Shang, Y. F., Kampinga, H. H., Su, T. T., Sibon, O. C. M. A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress. Cytometry Part A 73A(7): , Zidan, J., Niessen, R. C., Laitman, Y., Rozeveld, D., Hofstra, R. M. W., Friedman, E. A novel MSH2 germline mutation in a Druze HNPCC family. Familial Cancer 7(2): , Rijcken, F. E. M., Koornstra, J. J., van der Sluis, T., Ek, W. B. V., Kleibeuker, J. H., Hollema, H. Early carcinogenic events in HNPCC adenomas: Differences with sporadic adenomas. Digestive Diseases and Sciences 53(6): , GUIDE Annual Publication Report

43 Research Line Hematopoetic development and hemato-oncology Dissertations Booman, M. The role of immunoediting in lymphomas of immune-privileged sites. (2008) Kluin, P. M., Schuuring, E., and de Jong, D. Houwerzijl, E. J. Studies on megakaryopoiesis in patients with myelodysplasia and idiopathic thrombocytopenic purpura. (2008) Vellenga, E., Wolf, J. Th. M. de, and Want, J. J. L. Wang, M. Kinases and mirnas in the pathogenesis of small B cell lymphomas. (2008) Kluin, P. M. and Visser, L. Journal Articles Ades, L., Sanz, M. A., Chevret, S., Montesinos, P., Chevallier, P., Raffoux, E., Vellenga, E., Guerci, A., Pigneux, A., Huguet, F., Rayon, C., Stoppa, A. M., de la Serna, J., Cahn, J. Y., Meyer- Monard, S., Pabst, T., Thomas, X., de Botton, S., Parody, R., Bergua, J., Lamy, T., Vekhoff, A., Negri, S., Ifrah, N., Dombret, H., Ferrant, A., Bron, D., Degos, L., Fenaux, P. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results. Blood 111(3): , Bakker, N. A., van Dijk, J. M. C., Slart, R. H. J. A., Coppes, M. H., van Imhoff, G. W., Verschuuren, E. A. M. Extradural thoracic spinal cord compression: Unusual initial presentation of posttransplant lymphoproliferative disorder. Journal of Heart and Lung Transplantation 27(10): , Bakker, N. A., van Imhoff, G. W., van Son, W. J., Kluin, Ph, Kluin- Nelemans, J. C., Verschuuren, E. A. M. Lymphoma in patients who have undergone organ transplantation: Severe and variable clinical presentation. Nederlands Tijdschrift voor Geneeskunde 152(19): , Bakker, N. A., Verschuuren, E. A., Veeger, N. J., van der Bij, W., van Imhoff, G. W., Kallenberg, C. G., Hepkema, B. G. Quantification of Epstein-Barr virus-dna load in lung transplant recipients: A comparison of plasma versus whole blood. Journal of Heart and Lung Transplantation 27(1): 7-10, Banks, P. M., Chan, J. K. C., Chan, W. C., Chott, A., Favera, R. D., De Wolf-Peeters, C., Delsol, G. G., Dyer, M., Campo, E., Falini, B., Gascoyne, R., Gatter, K., Gaulard, P., Grogan, T., Harris, N. L., Isaacson, P. G., Jaffe, E. S., Kluin, P. M., Knowles, D. M., Mori, S., Mueller-Hermelink, H. K., Nakamura, S., Pileri, S., Piris, M., Ralfkiaer, E., Siebert, R., Stein, H., Su, I. J., Swerdlow, S. H., Warnke, R., Weiss, L. David York Mason ( ). Antibody wizard and a founder of modern hemopathology. Haematologica-the Hematology Journal 93(7): A-B, Bekkema, R., Tadema, A., Daenen, S. M. G. J., Kluin-Nelemans, H. C., Mulder, A. B. An improved flow cytometric method using FACS lysing solution for measurement of ZAP-70 expression in B-cell chronic lymphocytic leukemia. Cytometry Part B-Clinical Cytometry 74B(1): 40-44, Booman, M., Szuhai, K., Rosenwald, A., Hartmann, E., Kluin- Nelemans, H. C., de Jong, D., Schuuring, E., Kluin, P. M. Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways. Journal of Pathology 216(2): , Breitling, R., Li, Y., Tesson, B. M., Fu, J. Y., Wu, C. L., Wiltshire, T., Gerrits, A., Bystrykh, L. V., de Haan, G., Su, A. I., Jansen, R. C. Genetical Genomics: Spotlight on QTL Hotspots. PLoS Genetics 4(10) Buijsrogge, J. J. A., Kluin, P. M., van Voorst Vader, P. C. Atopic dermatitis with CD30+ lymphomatoid. Nederlands Tijdschrift voor Dermatologie en Venereologie 18(9): , de Jonge, H. J. M., Weidenaar, A. C., ter Elst, A., Boezen, H. M., Scherpen, F. J. G., Steege, J. C. A. B., Kaspers, G. J. L., Goemans, B. F., Creutzig, U., Zimmermann, M., Kamps, W. A., de Bont, E. S. J. M. Endogenous vascular endothelial growth factor-c expression is associated with decreased drug responsiveness in childhood acute myeloid leukemia. Clinical Cancer Research 14(3): , de la Serna, J., Montesinos, P., Vellenga, E., Rayon, C., Parody, R., Leon, A., Esteve, J., Bergua, J. M., Milone, G., Deben, G., Rivas, C., Gonzalez, M., Tormo, M., az-mediavilla, J., Gonzalez, J. D., Negri, S., Amutio, E., Brunet, S., Lowenberg, B., Sanz, M. A. Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin. Blood 111(7): , de Vries, A. P. J., Bakker, S. J. L., Kallenberg, C. G. M., Gans, R. O. B., Bongaerts, A. H. H., Kluin, P. M. Cavitating lymph node syndrome. Netherlands Journal of Medicine 66(9): , Deenik, W., van der Holt, B., Verhoef, G. E. G., Smit, W. M., Kersten, M. J., Kluin-Nelemans, H. C., Verdonck, L. F., Ferrant, A., Schattenberg, A. V. M. B., Janssen, J. J. W. M., Sonneveld, P., Kooy, M. V., Wittebol, S., Willemze, R., Wijermans, P. W., Westveer, P. H. M., Beverloo, H. B., Valk, P., Lowenberg, B., Ossenkoppele, G. J., Cornelissen, J. J. Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia. Blood 111(5): , Diepstra, A., Poppema, S., Boot, M., Visser, L., Nolte, I. M., Niens, M., te Meerman, G. J., van den Berg, A. HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma. Tissue Antigens 71(3): , Donker, M. L., van Doormaal, J. J., van Doormaal, F. F., Kluin, P. M., van der Veer, E., de Monchy, J. G. R., Kema, I. P., Kluin-Nelemans, H. C. Biochemical markers predictive for bone marrow involvement in systemic mastocytosis. Haematologica-the Hematology Journal 93(1): , Dykstra, B., de Haan, G. Hematopoietic stem cell aging and selfrenewal. Cell and Tissue Research 331(1): , GUIDE Annual Publication Report

44 Fatrai, S., Schepers, H., Tadema, H., Vellenga, E., Daenen, S. M. G. J., Schuringa, J. J. Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases. Experimental Hematology 36(10): , Fuhler, G. M., Drayer, A. L., Olthof, S. G. M., Schuringa, J. J., Coffer, P. J., Vellenga, E. Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell-derived factor-1-induced migration of CD34(+) cells from patients with myelodysplasia. Blood 111(1): , Gerrits, A., Dykstra, B., Otten, M., Bystrykh, L., de Haan, G. Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny. Immunogenetics 60(8): , Gualco, G., van den Berg, A., Koopmans, S., Bacchi, L. M., Carneiro, S. S., Ruiz, E., Vecchi, A. P., Chan, J. K. C. Autoimmune lymphoproliferative syndrome in a patient with a new minimal deletion in the death domain of the FAS gene. Human Pathology 39(1): , Guikema J.E.J., Schuuring E., Kluin P.M. Structure and consequences of IGH switch breakpoints in Burkitt lymphoma. Journal of the National Cancer Institute - Monographs 39: 32-35, Hoster, E., Dreyling, M., Klapper, W., Gisselbrecht, C., van Hoof, A., Kluin-Nelemans, H. C., Pfreundschuh, M., Reiser, M., Metzner, B., Einsele, H., Peter, N., Jung, W., Wormann, B., Ludwig, W. D., Duhrsen, U., Eimermacher, H., Wandt, H., Hasford, J., Hiddemann, W., Unterhalt, M. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood 111(2): , Kluin-Nelemans, H. C., Coenen, J. L., Boers, J. E., van Imhoff, G. W., Rosati, S. EBV-positive immunodeficiency lymphoma after alemtuzumab-chop therapy for peripheral T-cell lymphoma. Blood 112(4): , Liu, A., Takakuwa, T., Fujita, S., Luo, W. J., Tresnasari, K., van den Berg, A., Poppema, S., Aozasa, K. ATR alterations in Hodgkin's lymphoma. Oncology Reports 19(4): , Ma, Y., Visser, L., Roelofsen, H., de Vries, M., Diepstra, A., van Imhoff, G., van der Wal, T., Luinge, M., varez-llamas, G., Vos, H., Poppema, S., Vonk, R., van den Berg, A. Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. Blood 111(4): , Ma, Y., Visser, L., Blokzijl, T., Harms, G., Atayar, C., Poppema, S., van den Berg, A. The CD4+CD26-T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile. Laboratory Investigation 88(5): , Morschhauser, F., Seymour, J. F., Kluin-Nelemans, H. C., Grigg, A., Wolf, M., Pfreundschuh, M., Tilly, H., Raemaekers, J., van 't Veer, M. B., Milpied, N., Cartron, G., Pezzutto, A., Spencer, A., Reyes, F., Dreyling, M. A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Annals of Oncology 19(2): , Niens, M., Visser, L., Nolte, I. M., van der Steege, G., Diepstra, A., Cordano, P., Jarrett, R. F., te Meerman, G. J., Poppema, S., van den Berg, A. Serum chemokine levels in Hodgkin lymphoma patients: highly increased levels of CCL17 and CCL22. British Journal of Haematology 140(5): , Olthof, S. G., Fatrai, S., Drayer, A. L., Tyl, M. R., Vellenga, E., Schuringa, J. J. Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34(+) cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis. Stem Cells 26(7): , Rizo, A., Dontje, B., Vellenga, E., de Haan, G., Schuringa, J. J. Longterm maintenance of human hematopoietic stem/progenitor cells by expression of BMI1. Blood 111(5): , Salaverria, I., Zettl, A., Beaa, S., Hartmann, E. M., Dave, S. S., Wright, G. W., Boerma, E. 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46 Burlage, F. R., Roesink, J. M., Kampinga, H. H., Coppes, R. P., Terhaard, C., Langenduk, J. A., van Luijk, P., Stokman, M. A., Vissink, A. Protection of salivary function by concomitant pilocarpine during radiotherapy: A double-blind, randomized, placebo-controlled study. International Journal of Radiation Oncology Biology Physics 70(1): 14-22, Campbell-Verduyn, L., Elsinga, P. H., Mirfeizi, L., Dierckx, R. A., Feringa, B. L. Copper-free 'click': 1,3-dipolar cycloaddition of azides and arynes. Organic & Biomolecular Chemistry 6(19): , Cohen, J., Douma, W. R., van Ooijen, P. M. A., Willems, T. P., Dicken, V., Kuhnigk, J. M., ten Hacken, N. H. T., Postma, D. S., Oudkerk, M. Localization and Quantification of Regional and Segmental Air Trapping in Asthma. Journal of Computer Assisted Tomography 32(4): , de Decker, M., Bacher, K., Thierens, H., Slegers, G., Dierckx, R. A., de Vos, F. 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48 Karliczek, A., Zeebregts, C. J., Benaron, D. A., Coppes, R. P., Wiggers, T., van Dam, G. M. Preoperative irradiation with 5x5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection. International Journal of Colorectal Disease 23(11): , Kema, I. P., Koopmans, K. P., Elsinga, P. H., Brouwers, A. H., Jager, P. L., de Vries, E. G. E. Premedication With Carbidopa Masks Positive Finding of Insulinoma and beta-cell Hyperplasia in [F- 18]-Dihydroxy-Phenyl-Alanine Positron Emission Tomography REPLY. Journal of Clinical Oncology 26(32): , Klappe-Sabadi, G., Jansman, F. G. A., Honkoop, H. A., Otter, R., Willemse, P. H. B., Brouwers, J. R. B. J. Regionale verschillen in voorschrijfgedrag opnieuw getoetst. Pharmaceutisch Weekblad. Wetenschappelijk Platform 2(7): , Koopmans, K. P., de Groot, J. W. B., Plukker, J. T. M., de Vries, E. G. E., Kema, I. P., Sluiter, W. J., Jager, P. L., Links, T. P. 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J., Fry, L., Monkemuller, K. ERCP with the Balloon- Assisted Enteroscopy Technique: A Systematic Review. Digestive Diseases 26(4): , Koornstra, J. J., Weersma, R. K. Management of rectal foreign bodies: Description of a new technique and clinical practice guidelines. World Journal of Gastroenterology 14(27): , Kortekaas, R., Maguire, R. P., van Waarde, A., Leenders, K. L., Elsinga, P. H. Despite irreversible binding, PET tracer [C-11]- SA5845 is suitable for imaging of drug competition at sigma receptors - The cases of ketamine and haloperidol. Neurochemistry International 53(1-2): 45-50, Krabbe, C. A., Dijkstra, P. U., Pruim, J., van der Laan, B. F. M., van der Wal, J. E., Gravendeel, J. P., Roodenburg, J. L. N. FDG PET in oral and oropharyngeal cancer. Value for confirmation of NO neck and detection of occult metastases. Oral Oncology 44(1): 31-36, Leffers, N., Helfrich, W., Marike Boezen, H., Cohlen, B. J., Melief, K., Nijman, H. W. Antigen-specific active immunotherapy for ovarian cancer. Cochrane Database of Systematic Reviews -(3) Leffers, N., Lambeck, A. J. A., de Graeff, P., Bijlsma, A. Y., Daemen, T., van der Zee, A. G. J., Nijman, H. W. Survival of ovarian cancer patients overexpressing the tumour antigen p53 is diminished in case of MHC class I down-regulation. Gynecologic Oncology 110(3): , Ljumanovic, R., Langendijk, J. A., Hoekstra, O. S., Knol, D. L., Leemans, C. R., Castelijns, J. A. Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. European Radiology 18(10): , Lombaert, I. M., Brunsting, J. F., Wierenga, P. K., Faber, H., Stokman, M. A., Kok, T., Visser, W. H., Kampinga, H. H., de Haan, G., Coppes, R. P. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE 3(4): e2063, Lombaert, I. M. A., Brunsting, J. F., Wierenga, P. K., Kampinga, H. H., de Haan, G., Coppes, R. P. Cytokine Treatment Improves Parenchymal and Vascular Damage of Salivary Glands after Irradiation. Clinical Cancer Research 14(23): , Lombaert, I. M. A., Brunsting, J. F., Wierenga, P. K., Kampinga, H. H., de Haan, G., Coppes, R. P. Keratinocyte Growth Factor Prevents Radiation Damage to Salivary Glands by Expansion of the Stem/Progenitor Pool. Stem Cells 26(10): , Loose, D., Signore, A., Staelens, L., Bulcke, K. V., Vermeersch, H., Dierckx, R. A., Bonanno, E., de Wiele, C. V. I-123-interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma. European Journal of Nuclear Medicine and Molecular Imaging 35(2): , Loose, D., Signore, A., Bonanno, E., Vermeersch, H., Dierckx, R., Deron, P., van de Wiele, C. Prognostic value of CD25 expression on lymphocytes and tumor cells in squamous-cell carcinoma of the head and neck. Cancer Biotherapy and Radiopharmaceuticals 23(1): 25-33, Maduro, J. H., de Vries, E. G. E., Meersma, G. J., Hougardy, B. M. T., van der Zee, A. G. J., de Jong, S. Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiationinduced apoptosis. International Journal of Radiation Oncology Biology Physics 72(2): , Malviya, G., Signore, A., Lagana, B., Dierckx, R. A. Radiolabelled peptides and monoclonal antibodies for therapy decision making in inflammatory diseases. Current Pharmaceutical Design 14(24): , Meerwaldt, R., Links, T., Zeebregts, C., Smit, A. Re: "Plasma fluorescent oxidation products as potential markers of oxidative stress for epidemiologic studies". American Journal of Epidemiology 167(6): , Neels, O. C., Koopmans, K. P., Jager, P. L., Vercauteren, L., van Waarde, A., Doorduin, J., Timmer-Bosscha, H., Brouwers, A. H., GUIDE Annual Publication Report

49 de Vries, E. G. E., Dierckx, R. A. J. O., Kema, I. P., Elsinga, P. H. Manipulation of [C-11]-5-hydroxytryptophan and 6-[F- 18]fluoro-3,4-dihydroxy-L-phenylalanine accumulation in neuroendocrine tumor cells. Cancer Research 68(17): , Oldenhuis, C., Stegehuis, J. H., Walenkamp, A., de Jong, S., de Vries, E. Targeting TRAIL death receptors. Current Opinion in Pharmacology 8(4): , Oldenhuis, C. N. A. M., Oosting, S. F., Gietema, J. A., de Vries, E. G. E. Prognostic versus predictive value of biomarkers in oncology. European Journal of Cancer 44(7): , Omloo, J. M. T., Sloof, G. W., Boellaard, R., Hoekstra, O. S., Jager, P. L., van Dullemen, H. M., Fockens, P., Plukker, J. T. M., van Lanschot, J. J. B. Importance of fluorodeoxyglucose-positron emission tomography (FDG-PET) and endoscopic ultrasonography parameters in predicting survival following surgery for esophageal cancer. Endoscopy 40(6): , Phan, H. T. T., Jager, P. L., Plukker, J. T. M., Wolffenbuttel, B. H. R., Dierckx, R. A., Links, T. P. Comparison of C-11-methionine PET and F-18-fluorodeoxyglucose PET in differentiated thyroid cancer. Nuclear Medicine Communications 29(8): , Phan, H. T. T., Jager, P. L., Paans, A. M. J., Plukker, J. T. M., Sturkenboom, M. G. G., Sluiter, W. J., Wolffenbuttel, B. H. R., Dierckx, R. A. J. O., Links, T. P. The diagnostic value of I-124-PET in patients with differentiated thyroid cancer. European Journal of Nuclear Medicine and Molecular Imaging 35(5): , Phan, H. T. T., Jager, P. L., van der Wal, J. E., Sluiter, W. J., Plukker, J. T. M., Dierckx, R. A. J. O., Wolffenbuttel, B. H. R., Links, T. P. The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. European Journal of Endocrinology 158(1): 77-83, Pultrum, B. B., van Bastelaar, J., Schreurs, L. M. A., van Dullemen, H. M., Groen, H., Nijsten, M. W. N., van Dam, G. M., Plukker, J. T. H. M. Impact of splenectomy on surgical outcome in patients with cancer of the distal esophagus and gastro-esophageal junction. Diseases of the Esophagus 21(4): , Rijcken, F. E. M., Koornstra, J. J., van der Sluis, T., Ek, W. B. V., Kleibeuker, J. H., Hollema, H. Early carcinogenic events in HNPCC adenomas: Differences with sporadic adenomas. Digestive Diseases and Sciences 53(6): , Rikhof, B., van der Graaf, W. T. A., Meijer, C., Le, P. T. K., Meersma, G. J., de Jong, S., Fletcher, J. A., Suurmeijer, A. J. H. Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL. British Journal of Cancer 99(10): , Rybczynska, A. A., Dierckx, R. A., Ishiwata, K., Elsinga, P. H., van Waarde, A. Cytotoxicity of sigma-receptor Ligands Is Associated with Major Changes of Cellular Metabolism and Complete Occupancy of the sigma-2 Subpopulation. Journal of Nuclear Medicine 49(12): , Schaapveld, M., Visser, O., Louwman, M. J., de Vries, E. G. E., Willemse, P. H. B., Otter, R., van der Graaf, W. T. A., Coebergh, J. W. W., van Leeuwen, F. E. Risk of new primary nonbreast cancers after breast cancer treatment: A Dutch populationbased study. Journal of Clinical Oncology 26(8): , Schaapveld, M., Visser, O., Louwman, W. J., Willemse, P. H. B., de Vries, E. G. E., van der Graaf, W. T. A., Otter, R., Coebergh, J. W. W., van Leeuwen, F. E. The impact of adjuvant therapy on contralateral breast cancer risk and the prognostic significance of contralateral breast cancer: a population based study in the Netherlands. Breast Cancer Research and Treatment 110(1): , Schreurs, L. M., Pultrum, B. B., Koopmans, K. P., Verhoef, C. C., Jager, P. L., van Dam, G. M., Groen, H., van der Jagt, E. J., Plukker, J. T. M. Better assessment of nodal metastases by PET/CT fusion compared to side-by-side PET/CT in oesophageal cancer. Anticancer Research 28(3B): , Schreurs, L. M. A., Verhoef, C. C. P. M., van der Jagt, E. J., van Dam, G. M., Groen, H., Plukker, J. T. M. Current relevance of cervical ultrasonography in staging cancer of the esophagus and gastroesophageal junction. European Journal of Radiology 67(1): , Schrijivers, M. L., van der Laan, B. F. A. M., de Bock, G. H., Pattje, W. J., Mastik, M. F., Menkema, L., Langendijk, J. A., Kluin, P. M., Schuuring, E., van der Wal, J. E. Overexpression of intrinsic hypoxia markers HIF1 alpha and CA-IX predict for local recurrence in stage T1-T2 glottic laryngeal carcinoma treated with radiotherapy. International Journal of Radiation Oncology Biology Physics 72(1): , Selgrad, M., Koornstra, J. J., Fini, L., Blom, M., Huang, R., DeVol, E. B., Boersma-van Ek, W., Dijkstra, G., Verdonk, R. C., de Jong, S., Goel, A., Williams, S. L., Meyer, R. L., Haagsma, E. B., Ricciardiello, L., Boland, C. R. JC Virus Infection in Colorectal Neoplasia That Develops after Liver Transplantation. Clinical Cancer Research 14(20): , Siemerink, E. J. M., Mulder, N. H., Brouwers, A. H., Hospers, G. A. P. F-18-fluorodeoxyglucose positron emission tomography for monitoring response to sorafenib treatment in patients with hepatocellular carcinoma. Oncologist 13(6): , Tanke, M. A. C., Kema, I. P., Dijck-Brouwer, J., Doornbos, B., de Vries, E. G. E., Korf, J. Low plasma tryptophan in carcinoid patients is associated with increased urinary cortisol excretion. Psychoneuroendocrinology 33(9): , ten Heuvel, S. E., Hoekstra, H. J., Suurmeijer, A. J. H. Diagnostic accuracy of FISH and RT-PCR in 50 routinely processed synovial sarcomas. Applied Immunohistochemistry & Molecular Morphology 16(3): , van Beek, A. P., van den Bergh, A. C. M., van den Berg, L. M., van den Berg, G., Keers, J. C., Langenduk, J. A., Wolffenbuttel, B. H. R. Subjective ratings vs. objective measurement of cognitive function: In regard to van Beek et al (Int J Radiat Oncol Biol Phys 2007;68 : ) - In response to Dr. Klein et al. 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50 van der Deen, M., Homan, S., Timmer-Bosscha, H., Scheper, R. J., Timens, W., Postma, D. S., de Vries, E. G. Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells. International Journal of COPD 3(3): , van der Horst-Schrivers, A. N. A., Slot, M. H. E. B., Willemse, P. H. B., Kema, I. P., de Vries, E. G. E., Wymenga, A. N. M. Effect of interferon and 5-fluorouracil on serum VEGF levels in neuroendocrine tumours. Acta Oncologica 47(1): , van der Laan, H. P., Dolsma, W. V., Maduro, J. H., Korevaar, E. W., Langendijk, J. A. Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy. Radiation Oncology 3 AR 6 DI / X-3-6 van der Laan, H. P., van den Bergh, A., Schilstra, C., Vlasman, R., Meertens, H., Langendijk, J. A. Grading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancer. International Journal of Radiation Oncology Biology Physics 70(4): , van der Putten, L., Hoekstra, O. S., de Bree, R., Kuik, D. J., Comans, E. F. I., Langendijk, J. A., Leemans, C. R. 2-deoxy-2[F-18]FDG-PET for detection of recurrent laryngeal carcinoma after radiotherapy: Interobserver variability in reporting. Molecular Imaging and Biology 10(5): , van der Zee, A. G. J., Oonk, M. H., De Hullu, J. A., Ansink, A. C., Vergote, I., Verheijen, R. H., Maggioni, A., Gaarenstroom, K. N., Baldwin, P. J., Van Dorst, E. B., van der Velden, J., Hermans, R. H., van der Putten, H., Drouin, P., Schneider, A., Sluiter, W. J. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. Journal of Clinical Oncology 26(6): , van Luijk, P., Schippers, J. M. We need to bridge the gap between current practice in mathematical modeling and new insights obtained from radiobiology: Comment on Zhou et al. [Med. Phys. 34, (2007)]. Medical Physics 35(6): , van Ooijen, P. M. A., Broekema, A., Oudkerk, M. Use of a thinsection archive and enterprise 3-dimensional software for longterm storage of thin-slice CT data sets - A reviewers' response. Journal of Digital Imaging 21(2): , van Waarde, A. PET and SPECT in Drug Evaluation and Drug Design Imaging Inflammatory Processes, Tumors, and the Endocannabinoid System. Current Pharmaceutical Design 14(31): , van Waarde, A., Elsinga, P. H. Proliferation Markers for the Differential Diagnosis of Tumor and Inflammation. Current Pharmaceutical Design 14(31): , van Waarde, A., Doorduin, J., de Jong, J. R., Dierckx, R. A., Elsinga, P. H. Synthesis and preliminary evaluation of (S)-[C-11]-exaprolol, a novel beta-adrenoceptor ligand for PET. Neurochemistry International 52(4-5): , Wang, Y., van Klaveren, R. J., van der Zaag-Loonen, H. J., de Bock, G. H., Gietema, H. A., Xu, D. M., Leusveld, A. L. M., de Koning, H. J., Scholten, E. T., Verschakelen, J., Prokop, M., Oudkerk, M. Effect of nodule characteristics on variability of semiautomated volume measurements in pulmonary nodules detected in a lung cancer screening program. Radiology 248(2): , Westerhof, J., Koornstra, J. J., Weersma, R. K. Capsule endoscopy: A review from the clinician's perspectives. Minerva Gastroenterologica e Dietologica 54(2): , Westerman, M. J., Hak, T., Sprangers, M. A. G., Groen, H. J. M., van der Wal, G., The, A. M. Listen to their answers! Response behaviour in the measurement of physical and role functioning. Quality of Life Research 17(4): , Widder, J., Kastenberger, R., Fercher, E., Schmid, R., Langendijk, J. A., Dobrowsky, W., Potter, R. Radiation dose associated with local control in advanced anal cancer: Retrospective analysis of 129 patients. Radiotherapy and Oncology 87(3): , Xu, D. M., van Klaveren, R. J., de Bock, G. H., Leusveld, A., Zhao, Y., Wang, Y., Vliegenthart, R., de Koning, H. J., Scholten, E. T., Verschakelen, J., Prokop, M., Oudkerk, M. Limited value of shape, margin and CT density in the discrimination between benign and malignant screen detected solid pulmonary nodules of the NELSON trial. European Journal of Radiology 68(2): , Zeng, W., Gouw, A. S. H., van den Heuvel, M. C., Zwiers, P. J., Zondervan, P. E., Poppema, S., Zhang, N., Platteel, I., de Jong, K. P., Molema, G. The Angiogenic Makeup of Human Hepatocellular Carcinoma Does Not Favor Vascular Endothelial Growth Factor/Angiopoletin-Driven Sprouting Neovascularization. Hepatology 48(5): , Zhang, H., Rodiger, L. A., Shen, T., Miao, J., Oudkerk, M. Perfusion MR imaging for differentiation of benign and malignant meningiomas. Neuroradiology 50(6): , Zhang, H., Rodiger, L. A., Shen, T. Z., Miao, J. T., Oudkerk, M. Preoperative subtyping of meningiomas by perfusion MR imaging. Neuroradiology 50(10): , Research Line Clinical Studies Dissertations Been, L. B. Imaging proliferation with [18F]FLT-PET : therapy evaluation studies. (2008) Hoekstra, H. J., Elsinga, P. H., and Suurmeijer, A. J. H. Blaauwbroek, R. Caring for adult survivors of childhood cancer : the role of the general practitioner. (2008) Kamps, W. A., Meyboom-de Jong, B., and Postma, A. Brouwer, C. A. J. Cardiovascular late effects in Adult survivors of Childhood Cancer. (2008) Kamps, W. A., Gietema, J. A., de Vries, E. G. E., and Postma, A. GUIDE Annual Publication Report

51 Buijs, C. Long-term side effects of adjuvant breast cancer treatment. (2008) de Vries, E. G. E., Willemse, P. H. B., and Mourits, M. J. E. Burlage, F. R. The role of pilocarpine in the reduction of radiation induced damage to the salivary glands. (2008) Langendijk, J. A., Vissink, A., Kampinga, H. H., and Coppes, R. P. de Jong, W. K. Thoracic tumors: prognostic and thearapeutic improvements. (2008) Groen, H. J. M. Horst-Schrivers, A. N. A. van der. Prognosis, follow-up and quality of life in patients with neuroendocrine tumours. (2008) de Vries, E. G. E., Willemse, P. H. B., Wymenga, A. N. M., Links, T. P., and Kema, I. P. Kelder, W. Lymph node staging in colon cancer. (2008) Wiggers, T. Nieboer, P. High-dose chemotherapy : studies on supportive care, quality of life and late effects of treatment. (2008) de Vries, E. G. E., Graaf, W. T. A. van der, and Mulder, N. H. Tuinman, M. A. Surviving testicular cancer: relationship aspects. (2008) Sleijfer, D. and Hoekstra, H. J. Journal Articles Abma, E. M., Kluin, P. M., Dullaart, R. P. F. Malignant aldosteroneproducing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism. Netherlands Journal of Medicine 66(6): , Ades, L., Sanz, M. A., Chevret, S., Montesinos, P., Chevallier, P., Raffoux, E., Vellenga, E., Guerci, A., Pigneux, A., Huguet, F., Rayon, C., Stoppa, A. M., de la Serna, J., Cahn, J. Y., Meyer- Monard, S., Pabst, T., Thomas, X., de Botton, S., Parody, R., Bergua, J., Lamy, T., Vekhoff, A., Negri, S., Ifrah, N., Dombret, H., Ferrant, A., Bron, D., Degos, L., Fenaux, P. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results. Blood 111(3): , Bakker, N. A., van Dijk, J. M. C., Slart, R. H. J. A., Coppes, M. H., van Imhoff, G. W., Verschuuren, E. A. M. Extradural thoracic spinal cord compression: Unusual initial presentation of posttransplant lymphoproliferative disorder. Journal of Heart and Lung Transplantation 27(10): , Bakker, N. A., van Imhoff, G. W., van Son, W. J., Kluin, Ph, Kluin- Nelemans, J. C., Verschuuren, E. A. M. Lymphoma in patients who have undergone organ transplantation: Severe and variable clinical presentation. Nederlands Tijdschrift voor Geneeskunde 152(19): , Bakker, N. A., Verschuuren, E. A., Veeger, N. J., van der Bij, W., van Imhoff, G. W., Kallenberg, C. G., Hepkema, B. G. Quantification of Epstein-Barr virus-dna load in lung transplant recipients: A comparison of plasma versus whole blood. Journal of Heart and Lung Transplantation 27(1): 7-10, Bartels, H., Middel, B. L., van der Laan, B. F. A. M., Staal, M. J., Albers, F. W. J. The Additive Effect of Co-Occurring Anxiety and Depression on Health Status, Quality of Life and Coping Strategies in Help-Seeking Tinnitus Sufferers. Ear and Hearing 29(6): , Blaauwbroek, R., Tuinier, W., Jong, B. M., Kamps, W. A., Postma, A. Shared care by paediatric oncologists and family doctors for long-term follow-up of adult childhood cancer survivors: a pilot study. Lancet Oncology 9(3): , Boellaard, R., Oyen, W. J. G., Hoekstra, C. J., Hoekstra, O. S., Visser, E. P., Willemsen, A. T., Arends, B., Verzijlbergen, F. J., Zijlstra, J., Paans, A. M., Comans, E. F. I., Pruim, J. The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials. European Journal of Nuclear Medicine and Molecular Imaging 35(12): , Breukink, S., Driel, M., Pierie, J., Dobbins, C., Wiggers, T., Meijerink, W. Male sexual function and lower urinary tract symptoms after laparoscopic total mesorectal excision. International Journal of Colorectal Disease 23(12): , Buijs, C., de Vries, E. G. E., Mourits, M. J. E., Willemse, P. H. B. The influence of endocrine treatments for breast cancer on healthrelated quality of life. Cancer Treatment Reviews 34(7): , Burlage, F. R., Roesink, J. M., Faber, H., Vissink, A., Langendijk, J. A., Kampinga, H. H., Coppes, R. P. Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment. Radiotherapy and Oncology 86(3): , Burlage, F. R., Roesink, J. M., Kampinga, H. H., Coppes, R. P., Terhaard, C., Langenduk, J. A., van Luijk, P., Stokman, M. A., Vissink, A. Protection of salivary function by concomitant pilocarpine during radiotherapy: A double-blind, randomized, placebo-controlled study. International Journal of Radiation Oncology Biology Physics 70(1): 14-22, de Bock, G. H., Jacobi, C. E., Seynaeve, C., Krol-Warmerdam, E. M. M., Blom, J., van Asperen, C. J., Cornelisse, C. J., Klijn, J. G. M., Devilee, P., Tollenaar, R. A. E. M., Brekelmans, C. T. M., van Houwelingen, J. C. A family history of breast cancer will not predict female early onset breast cancer in a population-based setting. BMC Cancer 8 AR 203 DI / : 203, de Haas, E. C., Di Pietro, A., Simpson, K. L., Meijer, C., Suurmeijer, A. J. H., Lancashire, L. J., Cummings, J., de Jong, S., de Vries, E. G. E., Dive, C., Gietema, J. A. Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drugsensitive tumor, testicular cancer. Neoplasia 10(10): , de Haas, E. C., Zwart, N., Meijer, C., Nuver, J., Boezen, H. M., Suurmeijer, A. J. H., Hoekstra, H. J., van der Steege, G., Sleijfer, D. T., Gietema, J. A. Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. Journal of Clinical Oncology 26(11): , GUIDE Annual Publication Report

52 de Jong, W. K., Schaapveld, M., Blaauwgeers, J. L. G., Groen, H. J. M. Pulmonary tumours in the Netherlands: focus on temporal trends in histology and stage and on rare tumours. Thorax 63(12): , de Jong, W. K., Blaauwgeers, J. L. G., Schaapveld, M., Timens, W., Klinkenberg, T. J., Groen, H. J. M. Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy. European Journal of Cancer 44(1): , de Jong, W. X., de Jonge, M. J. A., van der Leest, A. H. D., van Meerbeeck, J. P., Groen, H. J. M. Irinotecan and cisplatin with concurrent thoracic radiotherapy in a once-every-three-weeks schedule in patients with limited-disease small-cell lung cancer: A phase I study. Lung Cancer 61(1): , de la Serna, J., Montesinos, P., Vellenga, E., Rayon, C., Parody, R., Leon, A., Esteve, J., Bergua, J. M., Milone, G., Deben, G., Rivas, C., Gonzalez, M., Tormo, M., az-mediavilla, J., Gonzalez, J. D., Negri, S., Amutio, E., Brunet, S., Lowenberg, B., Sanz, M. A. Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin. Blood 111(7): , de Vries, M. M., Persoon, A. C. M., Jager, P. L., Gravendeel, J., Plukker, J. T. M., Sluiter, W. J., Links, T. P. Embolization Therapy of Bone Metastases from Epithelial Thyroid Carcinoma: Effect on Symptoms and Serum Thyroglobulin. Thyroid 18(12): , de Vries, R., Daenen, S., Tolley, K., Glasmacher, A., Prentice, A., Howells, S., Christopherson, H., de Jong-van den Berg, Postma, M. J. Cost effectiveness of itraconazole in the prophylaxis of invasive fungal infections. Pharmacoeconomics 26(1): 75-90, Deenik, W., van der Holt, B., Verhoef, G. E. G., Smit, W. M., Kersten, M. J., Kluin-Nelemans, H. C., Verdonck, L. F., Ferrant, A., Schattenberg, A. V. M. B., Janssen, J. J. W. M., Sonneveld, P., Kooy, M. V., Wittebol, S., Willemze, R., Wijermans, P. W., Westveer, P. H. M., Beverloo, H. B., Valk, P., Lowenberg, B., Ossenkoppele, G. J., Cornelissen, J. J. Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia. Blood 111(5): , Diepstra, A., Poppema, S., Boot, M., Visser, L., Nolte, I. M., Niens, M., te Meerman, G. J., van den Berg, A. HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma. Tissue Antigens 71(3): , Engelen, M. J. A., Bongaerts, A. H. H., Sluiter, W. J., De Haan, H. H., Bogchelman, D. H., TenVergert, E. M., Willemse, P. H. B., van der Zee, A. G. J. Distinguishing benign and malignant pelvic masses: The value of different diagnostic methods in everyday clinical practice. European Journal of Obstetrics Gynecology and Reproductive Biology 136(1): , Eskens, F., Mom, C. H., Planting, A. S. T., Gietema, J. A., Amelsberg, A., Huisman, H., van Doorn, L., Burger, H., Stopfer, P., Verweij, J., de Vries, E. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor I (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. British Journal of Cancer 98(1): 80-85, Feng, J. L., Coppes, R. P. Can We Rescue Salivary Gland Function after Irradiation? TheScientificWorldJournal 8: , Fiebrich, H. B., Brouwers, A. H., Links, T. P., de Vries, E. G. E. Myocardial metastases of carcinoid visualized by F-18- dihydroxy-phenyl-alanine positron emission tomography. Circulation 118(15): , Francken, A. B., Thompson, J. F., Bastiaannet, E., Hoekstra, H. J. Detection of the first recurrence in patients with melanoma: Three quarters by the patient, one quarter during outpatient follow-up. Nederlands Tijdschrift voor Geneeskunde 152(10): , Francken, A. B., Accortt, N. A., Shaw, H. M., Colman, M. H., Wiener, M., Soong, S. J., Hoekstra, H. J., Thompson, J. F. Follow-up schedules after treatment for malignant melanoma. British Journal of Surgery 95(11): , Francken, A. B., Accortt, N. A., Shaw, H. M., Wiener, M., Soong, S. J., Hoekstra, H. J., Thompson, J. F. Prognosis and determinants of outcome following locoregional or distant recurrence in patients with cutaneous melanoma. Annals of Surgical Oncology 15(5): , Gazendam-Donofrio, S. M., Hoekstra, H. J., van der Graaf, W. T. A., Pras, E., Visser, A., Huizinga, G. A., Hoekstra-Weebers, J. E. H. M. Quality of life of parents with children living at home: when one parent has cancer. Supportive Care in Cancer 16(2): , Greystoke, A., Cummings, J., Ward, T., Simpson, K., Renehan, A., Butt, F., Moore, D., Gietema, J., Blackhall, F., Ranson, M., Hughes, A., Dive, C. Optimisation of circulating biomarkers of cell death for routine clinical use. Annals of Oncology 19(5): , Groen, E. J., Roos, A., Muntinghe, F. L., Enting, R. H., de Vries, J., Kleibeuker, J. H., Witjes, M. J. H., Links, T. P., van Beek, A. P. Extraintestinal manifestations of familial adenomatous polyposis. Annals of Surgical Oncology 15(9): , Hoekstra, H. J. Extremity perfusion for sarcoma. Surgical Oncology Clinics of North America 17(4): 805-8DI, Hoekstra, H. J. Melanoma during pregnancy: therapeutic management and outcome. Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres dans les Recherches sur le Cancer 178(-): , Hoekstra, H. J. The European approach to in-transit melanoma lesions. International Journal of Hyperthermia 24(3): , Holzik, M. F. L., Sijmons, R. H., Hoekstra-Weebers, J. E. H. M., Sleijfer, D. T., Hoekstra, H. J. Clinical and genetic aspects of testicular germ cell tumours. Heredity Cancer in Clinical Practice 6(1): 3-14, GUIDE Annual Publication Report

53 Hoogendoorn, W. E., Hollema, H., van Boven, H. H., Bergman, E., De Leeuw-Mantel, G., Platteel, I., Fles, R., Nederlof, P. M., Mourits, M. J. E., van Leeuwen, F. E. Prognosis of uterine corpus cancer after tamoxifen treatment for breast cancer. Breast Cancer Research and Treatment 112(1): , Hoven-Gondrie, M. L., Thijssens, K. M. J., Geertzen, J. H. B., Pras, E., van Ginkel, R. J., Hoekstra, H. J. Isolated limb perfusion and external beam radiotherapy for soft tissue sarcomas of the extremity: Long-term effects on normal tissue according to the LENT-SOMA scoring system. Annals of Surgical Oncology 15(5): , Jansen, N. C. A. J., Kingma, A., Schuitema, A., Bouma, A., Veerman, A. J. P., Kamps, W. A. Neuropsychological outcome in chemotherapy-only-treated children with acute lymphoblastic leukemia. Journal of Clinical Oncology 26(18): , Jorna, F. H., Jager, P. L., Lemstra, C., Wiggers, T., Stegeman, C. A., Plukker, J. T. M. Utility of an intraoperabive gamma probe in the surgical management of secondary or tertiary hyperparathyroidism. American Journal of Surgery 196(1): 13-18, Karliczek, A., Benaron, D. A., Baas, P. C., Zeebregts, C. J., van der Stoel, A., Wiggers, T., Plukker, J. T. M., van Dam, G. M. Intraoperative Assessment of Microperfusion with Visible Light Spectroscopy in Esophageal and Colorectal Anastomoses. European Surgical Research 41(3): , Karliczek, A., Zeebregts, C. J., Benaron, D. A., Coppes, R. P., Wiggers, T., van Dam, G. M. Preoperative irradiation with 5x5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection. International Journal of Colorectal Disease 23(11): , Kelder, W., Inberg, B., Plukker, J. T. M., Groen, H., Baas, P. C., Tiebosch, A. T. M. G. Effect of modified Davidson's fixative on examined number of lymph nodes and TNM-stage in colon carcinoma. European Journal of Surgical Oncology 34(5): , Kluin-Nelemans, H. C., Coenen, J. L., Boers, J. E., van Imhoff, G. W., Rosati, S. EBV-positive immunodeficiency lymphoma after alemtuzumab-chop therapy for peripheral T-cell lymphoma. Blood 112(4): , Koopmans, K. P., de Groot, J. W. B., Plukker, J. T. M., de Vries, E. G. E., Kema, I. P., Sluiter, W. J., Jager, P. L., Links, T. P. F-18- Dihydroxyphenylalanine PET in patients with biochemical evidence of medullary thyroid cancer: Relation to tumor differentiation. Journal of Nuclear Medicine 49(4): , Koopmans, K. P., Neels, O. C., Kema, I. P., Elsinga, P. H., Sluiter, W. J., Vanghillewe, K., Brouwers, A. H., Jager, P. L., de Vries, E. G. E. Improved staging of patients with carcinoid and islet cell tumors with F-18-dihydroxy-phenyl-alanine and C-11-5-hydroxytryptophan positron emission tomography. Journal of Clinical Oncology 26(9): , Koornstra, J. J., van Dullemen, H. M., Weersma, R. K. A safe technique for removing a malpositioned covered biliary selfexpandable metal stent. Endoscopy 40 Suppl 2(-): E165, Koornstra, J. J., Kleibeuker, J. H. Electronic Clinical Challenges and Images in GI. Gastroenterology 134(3): e1-e2, Koornstra, J. J., Kleibeuker, J. H., Vasen, H. F. A. Small-bowel cancer in Lynch syndrome: is it time for surveillance? Lancet Oncology 9(9): , Koot, R. W., Habraken, J. B. A., Hulshof, M. C. C. M., Paans, A. M. J., Bosch, D. A., Pruim, J. What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by Ir-192 brachytherapy? Acta Neurochirurgica 150(4): , Kootstra, J., Hoekstra-Weebers, J. E. H. M., Rietman, H., de Vries, J., Baas, P., Geertzen, J. H. B., Hoekstra, H. J. Quality of life after sentinel lymph node biopsy or axillary lymph node dissection in stage I/II breast cancer patients: A prospective longitudinal study. Annals of Surgical Oncology 15(9): , Krabbe, C. A., Dijkstra, P. U., Pruim, J., van der Laan, B. F. M., van der Wal, J. E., Gravendeel, J. P., Roodenburg, J. L. N. FDG PET in oral and oropharyngeal cancer. Value for confirmation of NO neck and detection of occult metastases. Oral Oncology 44(1): 31-36, Lagarde, S. M., Franssen, S. J., van Werven, J. R., Smets, E. M. A., Tran, T. C. K., Tilanus, H. W., Plukker, J. T. M., de Haes, J. C. J. M., van Lanschot, J. J. B. Patient Preferences for the Disclosure of Prognosis After Esophagectomy for Cancer with Curative Intent. Annals of Surgical Oncology 15(11): , Lange, M. M., Maas, C. P., Marijnen, C. A. M., Wiggers, T., Rutten, H. J., Kranenbarg, E. K., van de Velde, C. J. H. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. British Journal of Surgery 95(8): , Langendijk, J. A., Doornaert, P., Verdonck-de Leeuw, I. M., Leemans, C. R., Aaronson, N. K., Slotman, B. J. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. Journal of Clinical Oncology 26(22): , Mantel, H. T. J., Verdonk, R. C., van Dullemen, H. M., Gietema, J. A., Slooff, M. J. H., Porte, R. J. Diagnosis and treatment of cholangiocarcinoma [4]. Nederlands Tijdschrift voor Geneeskunde 152(32): , Mantel, H. T. J., Verdonk, R. C., van Dullemen, H. M., Gietema, J. A., Slooff, M. J. H., Porte, R. J. Diagnostics and treatment of cholangiocarcinoma. Nederlands Tijdschrift voor Geneeskunde 152(18): , Meerwaldt, R., Links, T., Zeebregts, C., Tio, R., Hillebrands, J. L., Smit, A. The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes. Cardiovascular Diabetology 7 AR 29 DI / : 29, GUIDE Annual Publication Report

54 Milos, I. N., Frank-Raue, K., Wohllk, N., Maia, A. L., Pusiol, E., Patocs, A., Robledo, M., Biarnes, J., Barontini, M., Links, T. P., de Groot, J. W., Dvorakova, S., Peczkowska, M., Rybicki, L. A., Sullivan, M., Raue, F., Zosin, I., Eng, C., Neumann, H. P. H. Agerelated neoplastic risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germ line RET Cys634Trp (TGC > TGG) mutation. Endocrine-Related Cancer 15(4): , Morschhauser, F., Seymour, J. F., Kluin-Nelemans, H. C., Grigg, A., Wolf, M., Pfreundschuh, M., Tilly, H., Raemaekers, J., van 't Veer, M. B., Milpied, N., Cartron, G., Pezzutto, A., Spencer, A., Reyes, F., Dreyling, M. A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Annals of Oncology 19(2): , Nieboer, P., de Vries, E. G. E., Mulder, N. H., Rodenhuis, S., Bontenbal, M., van der Wall, E., van Hoesel, Q. G., Smit, W. M., Hupperets, P., Voest, E. E., Nooij, M. A., Boezen, H. M., van der Graaf, W. T. A. Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. Bone Marrow Transplantation 42(7): , Nieuwenhuis, M. H., Cappel, W. D. V. T., Botma, A., Nagengast, F. M., Kleibeuker, J. H., Mathus-Vliegen, E. M. H., Dekker, E., Dees, J., Wijnen, J., Vasen, H. F. A. Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis. Clinical Gastroenterology and Hepatology 6(2): , Oldenhuis, C. N. A. M., Oosting, S. F., Gietema, J. A., de Vries, E. G. E. Prognostic versus predictive value of biomarkers in oncology. European Journal of Cancer 44(7): , Olthof, M., Persoon, A. C. M., Plukker, J. T. M., van der Wal, J. E., Links, T. P. Anaplastic thyroid carcinoma with rhabdomyoblastic differentiation: A case report with a good clinical outcome. Endocrine Pathology 19(1): 62-65, Perik, P. J., Rikhof, B., de Jong, F. A., Verweij, J., Gietema, J. A., van der Graaf, W. T. A. Results of plasma N-terminal pro B-type natriuretic peptide and cardiac troponin monitoring in GIST patients do not support the existence of imatinib-induced cardiotoxicity. Annals of Oncology 19(2): , Phan, H. T. T., Jager, P. L., Plukker, J. T. M., Wolffenbuttel, B. H. R., Dierckx, R. A., Links, T. P. Comparison of C-11-methionine PET and F-18-fluorodeoxyglucose PET in differentiated thyroid cancer. Nuclear Medicine Communications 29(8): , Phan, H. T. T., Jager, P. L., Paans, A. M. J., Plukker, J. T. M., Sturkenboom, M. G. G., Sluiter, W. J., Wolffenbuttel, B. H. R., Dierckx, R. A. J. O., Links, T. P. The diagnostic value of I-124-PET in patients with differentiated thyroid cancer. European Journal of Nuclear Medicine and Molecular Imaging 35(5): , Phan, H. T. T., Jager, P. L., van der Wal, J. E., Sluiter, W. J., Plukker, J. T. M., Dierckx, R. A. J. O., Wolffenbuttel, B. H. R., Links, T. P. The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation. European Journal of Endocrinology 158(1): 77-83, Schoen, P. J., Raghoebar, G. M., Bouma, J., Reintsema, H., Burlage, F. R., Roodenburg, J. L. N., Vissink, A. Prosthodontic rehabilitation of oral function in head-neck cancer patients with dental implants placed simultaneously during ablative tumour surgery: an assessment of treatment outcomes and quality of life. International Journal of Oral and Maxillofacial Surgery 37(1): 8-16, Senft, A., de Bree, R., Hoekstra, O. S., Kuik, D. J., Golding, R. P., Oyen, W. J. G., Pruim, J., den Hoogen, F. J., Roodenburgh, J. L. N., Leemans, C. R. Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: A prospective multicenter trial. Radiotherapy and Oncology 87(2): , Siemerink, E. J. M., Mulder, N. H., Brouwers, A. H., Hospers, G. A. P. F-18-fluorodeoxyglucose positron emission tomography for monitoring response to sorafenib treatment in patients with hepatocellular carcinoma. Oncologist 13(6): , ten Heuvel, S. E., Hoekstra, H. J., Suurmeijer, A. J. H. Diagnostic accuracy of FISH and RT-PCR in 50 routinely processed synovial sarcomas. Applied Immunohistochemistry & Molecular Morphology 16(3): , Vale, C., Tierney, J. F., Stewart, L. A., Brady, M., Dinshaw, K., Jakobsen, A., Parmar, M. K. B., Thomas, G., Trimble, T., Alberts, D. S., Chen, H. W., Cikaric, S., Eifel, P. J., Garipagaoglu, M., Keys, H., Kantardzic, N., Lal, P., Lanciano, R., Leborgne, F., Lorvidhaya, V., Onishi, H., Pearcey, R. G., Pras, E., Roberts, K., Rose, P. G., Thomas, G., Whitney, C. W. Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials. Journal of Clinical Oncology 26(35): , van der Hem, P. S., Egges, M., van der Wal, J. E., Roodenburg, J. L. N. CO2 laser evaporation of oral lichen planus. International Journal of Oral and Maxillofacial Surgery 37(7): , van der Zee, A. G. J., Oonk, M. H., De Hullu, J. A., Ansink, A. C., Vergote, I., Verheijen, R. H., Maggioni, A., Gaarenstroom, K. N., Baldwin, P. J., Van Dorst, E. B., van der Velden, J., Hermans, R. H., van der Putten, H., Drouin, P., Schneider, A., Sluiter, W. J. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. Journal of Clinical Oncology 26(6): , van Zeeburg, H. J. T., Snijders, P. J. F., Wu, T., Gluckman, E., Soulier, J., Surralles, J., Castella, M., van der Wal, J. E., Wennerberg, J., Califano, J., Velleuer, E., Dietrich, R., Ebell, W., Bloemena, E., Joenje, H., Leemans, C. R., Brakenhoff, R. H. Clinical and Molecular Characteristics of Squamous Cell Carcinomas From Fanconi Anemia Patients. Journal of the National Cancer Institute 100(22): , van Zijp, J. V., Hoekstra, H. J., Basson, M. D. Evolving management of colorectal cancer. World Journal of Gastroenterology 14(25): , GUIDE Annual Publication Report

55 Vellenga, E., van Putten, W. L. J., van't Veer, M. B., Zijlstra, J. M., Fibbe, W. E., van Oers, M. H. J., Verdonck, L. F., Wijermans, P. W., van Imhoff, G. W., Lugtenburg, P. J., Huijgens, P. C. Rituximab improves the treatment results of DHAP-VIM-DHAP and ASCT in relapsed/progressive aggressive CD20(+) NHL: a prospective randomized HOVON trial. Blood 111(2): , Verdonk, R. C., Rutgevs, B., Hospers, G. A. P. Celiac trunk thrombosis and splenic infarction during chemotherapy for a testicular germ cell tumor. Urology 71(4): 602, Verdonk, R. C., Enting, R. H., Janmaat, M., Schroder, C. P., Sleijfer, D. T., Gietema, J. A. Weakness and numbness after chemotherapy for metastatic non-seminoma testis: A new neurological complication. Acta Oncologica 47(8): , Wang, Y., van Klaveren, R. J., van der Zaag-Loonen, H. J., de Bock, G. H., Gietema, H. A., Xu, D. M., Leusveld, A. L. M., de Koning, H. J., Scholten, E. T., Verschakelen, J., Prokop, M., Oudkerk, M. Effect of nodule characteristics on variability of semiautomated volume measurements in pulmonary nodules detected in a lung cancer screening program. Radiology 248(2): , GUIDE Annual Publication Report

56 INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY BDDD Research Line Pharmaceutical Biology Dissertations Lemke, A. New formulation approaches for the leishmanicidal drug Miltefosine and for the polyene antibiotic Amphotericin B. ( ) Kayser, O. and Quax, W. J. Westers, L. The BACELL factory and therapeutic proteins. (2008) Quax, W. J Journal Articles Boersma, Y. L., Droge, M. J., van der Sloot, A. M., Pijning, T., Cool, R. H., Dijkstra, B. W., Quax, W. J. A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A. ChemBioChem 9(7): , 5-5- Boersma, Y. L., Pijning, T., Bosma, M. S., van der Sloot, A. M., Godinho, L. F., Droge, M. J., Winter, R. T., van Pouderoyen, G., Dijkstra, B. W., Quax, W. J. Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity. Chemistry & Biology 15(8): , Duarte, N., Kayser, O., Abreu, P., Ferreira, M. J. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds. Phytotherapy Research 22(4): , Julsing, M., Fichera, M., Malz, F., Ebbelaar, M., Bos, R., Woerdenbag, H., Quax, W., Kayser, O. Bioconversion of Monoand Sesquiterpenoids by Recombinant Human Cytochrome P450 Monooxygenases. Pharmaceutical Biology 46(10-11): , Julsing, M. K., Vasilev, N. P., Schneidman-Duhovny, D., Muntendam, R., Woerdenbag, H. J., Quax, W. J., Wolfson, H. J., Ionkova, I., Kayser, O. Metabolic stereoselectivity of cytochrome P450 3A4 towards deoxypodophyllotoxin: In silico predictions and experimental validation. European Journal of Medicinal Chemistry 43(6): , Kouwen, T. R. H. M., Dubois, J. Y. F., Freudl, R., Quax, W. J., van Dijl, J. M. Modulation of Thiol-Disulfide Oxidoreductases for Increased Production of Disulfide-Bond-Containing Proteins in Bacillus subtilis. Applied and Environmental Microbiology 74(24): , Krzeslak, J., Gerritse, G., van Merkerk, R., Cool, R. H., Quax, W. J. Lipase expression in Pseudomonas alcaligenes is under the control of a two-component regulatory system. Applied and Environmental Microbiology 74(5): , different glutaryl hydolysis of acylase mutants to improve the cephalosporin C in the absence of hydrogen peroxide. Advanced Synthesis & Catalysis 350(2): , Poelarends, G. J., Serrano, H., Person, M. D., Johnson, W. H., Jr., Whitman, C. P. Characterization of Cg10062 from Corynebacterium glutamicum: implications for the evolution of cis-3-chloroacrylic acid dehalogenase activity in the tautomerase superfamily. Biochemistry 47(31): , 5-8- Poelarends, G. J., Veetil, V. P., Whitman, C. P. The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily. Cellular and Molecular Life Sciences 65(22): , Staniek, A., Woerdenbag, H. J., Kayser, O. Endophytes: exploiting biodiversity for the improvement of natural product - based drug discovery. Journal of Plant Interactions Vol. 3(No 2.): 75-93, Tarrus, M., van der Sloot, A. M., Temming, K., Lacombe, M., Opdam, F., Quax, W. J., Molema, G., Poelstra, K., Kok, R. J. RGD-avidin-biotin pretargeting to alpha(v)beta(3) integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL). Apoptosis 13(2): , Tur, V., van der Sloot, A. M., Reis, C. R., Szegezdi, E., Cool, R. H., Samali, A., Serrano, L., Quax, W. J. DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design. Journal of Biological Chemistry 283(29): , Wassenaar, T. A., Quax, W. J., Mark, A. E. The conformation of the extracellular binding domain of Death Receptor 5 in the presence and absence of the activating ligand TRAIL: a molecular dynamics study. Proteins 70(2): , 1-2- Weiner, B., Poelarends, G. J., Janssen, D. B., Feringa, B. L. Biocatalytic enantioselective synthesis of N-substituted aspartic acids by aspartate ammonia lyase. Chemistry 14(32): , Westers, L., Westers, H., Zanen, G., Antelmann, H., Hecker, M., Noone, D., Devine, K. M., van Dijl, J. M., Quax, W. J. Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome. Proteomics 8(13): , Lopez-Gallego, F., Betancor, L., Sio, C. E., Reis, C. R., Jimenez, P. N., Guisan, J. M., Quax, W. J., Fernandez-Lafuente, R. Evaluation of

57 Book (chapters) Poelarends, G. J., Whitman, C. P. Mechanistic and structural studies of microbial dehalogenases: How Nature cleaves a carbon-halogen bond.anonymous Elsevier, Oxford, UK., 2008, Patent applications Rodrigues dos Reis, C. R., Quax, W. J., Samali, A., Szegezdi, E., Natoni, A., Cool, R. H., van der Sloot, A. M., Serrano, L., Tur, V. Improved Cytokine Design. WO2008IB Samali, A., Szegezdi, E., Mahalingam D, Duiker E.W., de Vries, E. G. E., de Jong, S., Rodrigues dos Reis, C. R., de Ruijter, M., Cool, R. H., Quax, W. J. Trail variants for treating cancer. WO2008IB Research Line Pharmacokinetics and Drug Delivery Journal Articles De Kerkhof, E. G. V., de Graaf, I. A. M., Ungell, A. L. B., Groothuis, G. M. M. Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metabolism and Disposition 36(3): , Dolman, M. E. M., Fretz, M. M., Segers, G. W., Lacombe, M., Prakash, J., Storm, G., Hennink, W. E., Kok, R. J. Renal targeting of kinase inhibitors. International Journal of Pharmaceutics 364(2): , Elferink, M. G. L., Olinga, P., Draaisma, A. L., Merema, M. T., Bauerschmidt, S., Polman, J., Schoonen, W. G., Groothuis, G. M. M. Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. Toxicology and Applied Pharmacology 229(3): , Fretz, M. M., Dolman, M. E. M., Lacombe, M., Prakash, J., Nguyen, T. Q., Goldschmeding, R., Pato, J., Storm, G., Hennink, W. E., Kok, R. J. Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors. Journal of Controlled Release 132(3): , Hagens, W. I., Beljaars, L., Mann, D. A., Wright, M. C., Julien, B., Lotersztajn, S., Reker-Smit, C., Poelstra, K. Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers. Journal of Pharmacology and Experimental Therapeutics 324(3): , Klassen, L. W., Thiele, G. M., Duryee, M. J., Schaffert, C. S., DeVeney, A. L., Hunter, C. D., Olinga, P., Tuma, D. J. An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. Biochemical Pharmacology 76(3): , Olinga, P., Elferink, M. G. L., Draaisma, A. L., Merema, M., Castell, J. V., Perez, G., Groothuis, G. M. M. Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. European Journal of Pharmaceutical Sciences 33(4-5): , Plazar, J., Filipic, M., Groothuis, G. M. M. Antigenotoxic effect of Xanthohumol in rat liver slices. Toxicology in Vitro 22(2): , Prakash, J., de Borst, M. H., van Loenen-Weemaes, A. M., Lacombe, M., Opdam, F., van Goor, H., Meijer, D. K. F., Moolenaar, F., Poelstra, K., Kok, R. J. Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. Pharmaceutical Research 25(10): , Prakash, J., de Borst, M. H., Lacombe, M., Opdam, F., Klok, P. A., van Goor, H., Meijer, D. K. F., Moolenaar, F., Poelstra, K., Kok, R. J. Inhibition of Renal Rho Kinase Attenuates Ischemia/Reperfusion-Induced Injury. Journal of the American Society of Nephrology 19(11): , Prakash, J., Poelstra, K., van Goor, H., Moolenaar, F., Meijer, D. K. F., Kok, R. J. Novel therapeutic targets for the treatment of tubulointerstitial fibrosis. Current Signal Transduction Therapy 3(2): , Schoemaker, M. H., Rots, M. G., Beljaars, L., Ypma, A. Y., Jansen, P. L. M., Poelstra, K., Moshage, H., Haisma, H. J. PDGFreceptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics 5(3): , Tarrus, M., van der Sloot, A. M., Temming, K., Lacombe, M., Opdam, F., Quax, W. J., Molema, G., Poelstra, K., Kok, R. J. RGD-avidin-biotin pretargeting to alpha(v)beta(3) integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL). Apoptosis 13(2): , van de Bovenkamp, M., Groothuis, G. M. M., Meijer, D. K. F., Olinga, P. Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver. Toxicology in Vitro 22(3): , Research Line Pharmaceutical Technology and BioPharmacy Dissertations Amorij, J. P. The development of stable influenza vaccine powder formulations for new needle-free dosage forms. (2008) Frijlink, H. W. and Wilschut, J. C. Wu, Y. S. Looking into tablets. Characterization of pore structure in tablets using image analysis. ( ) Frijlink, H. W., van der Voort Maarschalk, K., and van Vliet, L. J. GUIDE Annual Publication Report

58 Journal Articles Amidi, M., Pellikaan, H. C., de Boer, A. H., Crommelin, D. J. A., Hennink, W. E., Jiskoot, W. Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery. European Journal of Pharmaceutics and Biopharmaceutics 68(2): , Amorij, J. P., Huckriede, A., Wischut, J., Frifflink, H. W., Hinrichs, W. L. J. Development of stable influenza vaccine powder formulations: Challenges and possibilities. Pharmaceutical Research 25(6): , Bouchard, A., Jovanovic, N., de Boer, A. H., Martin, A., Jiskoot, W., Crommelin, D. J. A., Hofland, G. W., Witkamp, G. J. Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying. European Journal of Pharmaceutics and Biopharmaceutics 70(1): , de Boer, A. H., Wissink, J., Hagedoorn, P., Heskamp, I., de Kruijf, W., Bunder, R., Zanen, P., Munnik, P., van Rijn, C., Frijlink, H. W. In vitro performance testing of the novel medspray (R) wet aerosol inhaler based on the principle of Rayleigh break-up. Pharmaceutical Research 25(5): , de Waard, H., Hinrichs, W. L. J., Frijlink, H. W. A novel bottom-up process to produce drug nanocrystals: Controlled crystallization during freeze-drying. Journal of Controlled Release 128(2): , de Waard, H., Hinrichs, W. L. J., Visser, M. R., Bologna, C., Frijlink, H. W. Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated. International Journal of Pharmaceutics 349(1-2): 66-73, Laksmana, F. L., Kok, P. J. A. H., Frijlink, H. W., Vromans, H., Maarschalk, K. V. D. V. Using the Internal Stress Concept to Assess the Importance of Moisture Sorption-induced Swelling on the Moisture Transport through the Glassy HPMC Films. AAPS PharmSciTech 9(3): , Moes, J. J., Ruijken, M. M., Gout, E., Frijlink, H. W., Ugwoke, M. I. Application of process analytical technology in tablet process development using NIR spectroscopy: Blend uniformity, content uniformity and coating thickness measurements. International Journal of Pharmaceutics 357(1-2): , Nieuwmeyer, F., Maarschalk, K. V., Vromans, H. Lactose contaminant as steroid degradation enhancer. Pharmaceutical Research 25(11): , Nieuwmeyer, F., Maarschalk, K. V., Vromans, H. The consequences of granulate heterogeneity towards breakage and attrition upon fluid-bed drying. European Journal of Pharmaceutics and Biopharmaceutics 70(1): , Schellekens, R. C. A., Stellaard, F., Mitrovic, D., Stuurman, F. E., Kosterink, J. G. W., Frijlink, H. W. Pulsatile drug delivery to ileocolonic segments by structured incorporation of disintegrants in ph-responsive polymer coatings. Journal of Controlled Release 132(2): 91-98, van Doorne, H. High-pressure treatment, a potential antimicrobial treatment for pharmaceutical preparations? A survey. PDA journal of Pharmaceutical Science and Technology 62(4): , Weda, M., Zanen, P., de Boer, A. H., Barends, D. M., Frijlink, H. W. The therapeutic index of locally acting inhaled drugs as a function of their fine particle mass and particle size distribution: a literature review. Current Drug Delivery 5(2): , Westerman, E. M., de Boer, A. H., Touw, D. J., Le Brun, P. P. H., Roldaan, A. C., Frijunk, H. W., Heijerman, H. G. M. Aerosolization of tobramycin (TOBI (R)) with the PARI LC Plus (R) reusable nebulizer: Which compressor to use? Comparison of the CR60 (R) to the PortaNeb (R) compressor. Journal of Aerosol Medicine and Pulmonary Drug Delivery 21(3): , Wu, Y. S., van Vliet, L. J., Frijlink, H. W., Stokroos, I., Maarschalk, K. V. Pore direction in relation to anisotropy of mechanical strength in a cubic starch compact. AAPS PharmSciTech 9(2): , Wu, Y. S., Frijlink, H. W., van Vliet, L. J., Maarschalk, K. V. Pore shape in the sodium chloride matrix of tablets after the addition of starch as a second component. European Journal of Pharmaceutics and Biopharmaceutics 70(2): , Book (chapters) Wesselingh, J. A., Frijlink, H. W. Mass transfer from solid oral dosage forms. In: Pharmaceutical Dosage Forms: Tablets (3rd ed), edited by L. L. Augsburger and S. W. Hoag, New York, London: Informa Healthcare, 2008, p Research Line Therapeutic Gene Modulation Journal Articles Antunes, I. F., Haisma, H. J., de Vries, E. F. J. Tumor-specific activation of prodrugs: is there a role for nuclear medicine? Nuclear Medicine Communications 29(10): , Beerens, A. M. J., Rots, M. G., Bermudez, B., de Vries, E. F. J., Haisma, H. J. Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity. Journal of Drug Targeting 16(1): 26-35, Bremer, E., van Dam, G. M., de Bruyn, M., van Riezen, M., Dijkstra, M., Kamps, G., Helfrich, W., Haisma, H. Potent Systemic Anticancer Activity of Adenovirally Expressed GUIDE Annual Publication Report

59 EGFR-Selective TRAIL Fusion Protein. Molecular Therapy 16(12): , Haisma, H. J., Kamps, J. A. A. M., Kamps, G. K., Plantinga, J. A., Rots, M. G., Bellu, A. R. Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages. Journal of General Virology 89: , Johnson, T. S., Mahnke, K., Storn, V., Schonfeld, K., Ring, S., Nettelbeck, D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E., Enk, A. H. Inhibition of Melanoma Growth by Targeting of Antigen to Dendritic Cells via an Anti-DEC-205 Single-Chain Fragment Variable Molecule. Clinical Cancer Research 14(24): , Schoemaker, M. H., Rots, M. G., Beljaars, L., Ypma, A. Y., Jansen, P. L. M., Poelstra, K., Moshage, H., Haisma, H. J. PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics 5(3): , 200 GUIDE Annual Publication Report

60 CENTER FOR SYNTHESIS AND ANALYSIS S&A Research Line Analytical Biochemistry and Pharmaceutical Analysis Dissertations Didraga, M. A. Analytical approaches towards structural characterization of human lung decorin. (2008) Postma, D. S, Bischoff, R., Kerstjens, H. A. M., and Barroso, B. Klein, T. Profiling of Soluble and Membrane-bound Metalloproteinases: a targetted proteomics approach. (2008) Bischoff, R. P. H. and Kauffman, H. F. van Zomeren, P. V. Chemometrics for drug impurity profiling: Optimisation of capillary electrophoresis and deconvolution of overlapping peaks. (2008) de Jong, G. J. and Verpoorte, E. M. J. Journal Articles Barents, M., Hillege, H. H. L., van der Horst, I. C. C., de Boer, R. A., Koster, J., Muskiet, F. A. J., de Jongste, M. J. L. BNP and NTproBNP, Predictors of 1-Year Mortality in Nursing Home Residents. Journal of the American Medical Directors Association 9(8): , Barents, M., van der Horst, I. C. C., Voors, A. A., Hillege, J. L., Muskiet, F. A. J., de Jongste, M. J. L. Prevalence and misdiagnosis of chronic heart failure in nursing home residents: the role of B- type natriuretic peptides. Netherlands Heart Journal 16(4): , Christin, C., Smilde, A. K., Hoefsloot, H. C. J., Suits, F., Bischoff, R., Horvatovich, P. L. Optimized time alignment algorithm for LC-MS data: Correlation optimized warping using component detection algorithm-selected mass chromatograms. Analytical Chemistry 80(18): , Du, P. C., Stolovitzky, G., Horvatovich, P., Bischoff, R., Lim, J., Suits, F. A noise model for mass spectrometry based proteomics. Bioinformatics 24(8): , Freije, R., Klein, T., Ooms, B., Kauffman, H. F., Bischoff, R. An integrated high-performance liquid chromatography-mass spectrometry system for the activity-dependent analysis of matrix metalloproteases. Journal of Chromatography A 1189(1-2): , Geurink, P., Klein, T., Leeuwenburgh, M., van der Marel, G., Kauffman, H., Bischoff, R., Overkleeft, H. A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinitybased metalloproteinase profiling protocol. Organic & Biomolecular Chemistry 6(7): , Hendriks, G., Uges, D. R. A., Franke, J. P. New practical algorithm for modelling analyte recovery in bioanalytical reversed phase and mixed-mode solid phase extraction. Journal of Pharmaceutical and Biomedical Analysis 48(1): , Hendriks, G., Uges, D. R. A., Franke, J. P. ph adjustment of human blood plasma prior to bioanalytical sample preparation. Journal of Pharmaceutical and Biomedical Analysis 47(1): , Kemperman, R. F. J., Muskiet, F. D., Boutier, A. I., Kema, I. P., Muskiet, F. A. J. Brief report: Normal intestinal permeability at elevated platelet serotonin levels in a subgroup of children with pervasive developmental disorders in Curacao (The Netherlands Antilles). Journal of Autism and Developmental Disorders 38(2): , Landburg, P. P., Teerlink, T., van Beers, E. J., Muskiet, F. A. J., Kappers-Klunne, M. C., van Esser, J. W. J., Mac Gillavry, M. R., Biemond, B. J., Brandjes, D. P. M., Duits, A. J., Schnog, J. J. Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension. Haematologica-the Hematology Journal 93(9): , Landburg, P. P., Teerlink, T., Muskiet, F. A. J., Duits, A. J., Schnog, J. J. B. Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis. American Journal of Hematology 83(7): , Permentier, H. P., Bruins, A. P., Bischoff, R. Electrochemistry-mass Spectrometry in drug metabolism and protein research. Mini- Reviews in Medicinal Chemistry 8(1): 46-56, Riemersma, M., Dijkstra, P. U., van Veldhuisen, D. J., Muskiet, F. A. J., van den Dungen, J. A. M. M., Geertzen, J. H. B. Mortality and preoperative cardiac function in vascular amputees: an N- terminal pro-brain natriuretic peptide (NT-proBNP) pilot study. Clinical Rehabilitation 22(1): 56-59, Suits, F., Lepre, J., Du, P. C., Bischoff, R., Horvatovich, P. Twodimensional method for time aligning liquid chromatographymass spectrometry data. Analytical Chemistry 80(9): , van Beers, E. J., Nur, E., Schaefer-Prokop, C. M., Mac Gillavry, M. R., van Esser, J. W. J., Brandjes, D. P. M., Kappers-Klunne, M. C., Duits, A. J., Muskiet, F. A. J., Schnog, J. J. B., Biemond, B. J. Cardiopulmonary imaging, functional and laboratory studies in sickle cell disease associated pulmonary hypertension. American Journal of Hematology 83(11): , van Goor, S. A., Dijck-Brouwer, D. A. J., Fokkema, M. R., van der Lest, T. H., Muskiet, F. A. J. Maternal and fetal brain contents of docosahexaenoic acid (DHA) and arachidonic acid (AA) at various essential fatty acid (EFA), DHA and AA dietary intakes during pregnancy in mice. Prostaglandins Leukotrienes and Essential Fatty Acids 78(3): , van Goor, S. A., Smit, E. N., Schaafsma, A., Dijck-Brouwer, D. A. J., Muskiet, F. A. J. Milk of women with lifetime consumption of the recommended daily intake of fish fatty acids should constitute the basis for the DHA contents of infant formula. Journal of Perinatal Medicine 36(6): , GUIDE Annual Publication Report

61 Windt, W. A. K. M., van Dokkuni, R. P. E., Kluppel, C. A., Jeronimus- Stratingh, C. M., Hut, F., de Zeeuw, D., Henning, R. H. Therapeutic resistance to angiotensin converting enzyme (ACE) inhibition is related to pharmacodynamic and -kinetic factors in 5/6 nephrectomized rats. European Journal of Pharmacology 580(1-2): , Book (chapters) Govorukhina, N., Horvatovich, P., Bischoff, R. Label-free proteomics of serum. In: Methods in Molecular Biology, Vol. 484: Functional Proteomics: Methods and Protocols, edited by J. D. Thompson, Totowa, NJ, USA: Humana Press, 2008, p van Midwoud, P. M., Verpoorte, E. Implementing sample preconcentration in microfluidic devices. In: Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, edited by J. P. Landers, Boca Raton, FL, USA: CRC Press-Taylor & Francis Group, 2008, p transporter knockout rats: An animal model for anxiety and depression disorders. Neuroscience 152(3): , Qin, S., van der Zeyden, M., Oldenziel, W. H., Cremers, T. I. F. H., Westerink, B. H. C. Microsensors for in vivo Measurement of Glutamate in Brain Tissue. Sensors 8(11): , van der Zeyden, M., Denziel, W. H., Rea, K., Cremers, T. I., Westerink, B. H. Microdialysis of GABA and glutamate: Analysis, interpretation and comparison with microsensors. Pharmacology Biochemistry and Behavior 90(2): , Liu, D. Y., Dijkstra, D., de Vries, J. B., Wikstrom, H. V. A novel synthesis and pharmacological evaluation of a potential dopamine D-1/D-2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10- aoctahydrobenzo[g]quinoline-6,7-diol. Bioorganic & Medicinal Chemistry 16(6): , N. Govorukhina. Biomarker discovery for cervical cancer. Methods and approaches, Saarbruecken, Germany:VDM Verlag Dr. Mueller, Research Line Biomonitoring and Sensoring Journal Articles Beyer, C. E., Cremers, T. I. F. H. Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin? European Journal of Pharmacology 580(3): , Dekeyne, A., la Cour, C. M., Gobert, A., Brocco, M., Lejeune, F., Serres, F., Sharp, T., Daszuta, A., Soumier, A., Papp, M., Rivet, J. M., Flik, G., Cremers, T. I., Muller, O., Lavielle, G., Millan, M. J. S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology 199(4): , Ebert, B., Anderson, N. J., Cremers, T. I., Rasmussen, S., Vogel, V., Fahey, J. M., Sanchez, C. Gaboxadol - a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing. Pharmacology Biochemistry and Behavior 90(1): , Millan, M. J., Loiseau, F., Dekeyne, A., Gobert, A., Flik, G., Cremers, T. I., Rivet, J. M., Sicard, D., Billiras, R., Brocco, M. S33138 (N-[4-[2- [(3aS, 9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]benzopyrano[3,4- c]pyrrol-2(3h)-yl)-e thyl]phenyl-acetamide), a preferential dopamine D-3 versus D-2 receptor antagonist and potential antipsychotic agent: III. Actions in models of therapeutic activity and induction of side effects. Journal of Pharmacology and Experimental Therapeutics 324(3): , Olivier, J. D. A., van der Hart, M. G. C., Van Swelm, R. P. L., Dederen, P. J., Homberg, J. R., Cremers, T., Deen, P. M. T., Cuppen, E., Cools, A. R., Ellenbroek, B. A. A study in male and female 5-HT GUIDE Annual Publication Report