Annual Publication Report 2010

Transcription

1 Annual Publication Report 2010 TABLE OF CONTENTS 2 GRONINGEN INSTITUTE FOR KIDNEY DISEASES GIKD 8 CARDIOVASCULAR CENTER CVC 18 GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD GRIAC 24 CENTER FOR LIVER, DIGESTIVE AND METABOLIC DISEASES CLDS 33 INSTITUTE FOR TRANSPLANTATION, IMMUNITY AND INFLAMMATION TRIO 46 NORTHERN NETHERLANDS ONCOLOGY CENTER NNOC 63 INSTITUTE FOR BIOPHARMACEUTICALS: DISCOVERY, DESIGN AND DELIVERY BDDD 68 CENTER FOR SYNTHESIS AND ANALYSIS S&A

2 GRONINGEN INSTITUTE FOR KIDNEY DISEASES - GIKD Dissertations Gross, S. Advanced glycation and inflammatory phenomena in renal transplantion. (2010) Gans, R. O. B., Bierhaus, A. I., and Bakker, S. J. L. Halbesma, N. Predictors of accelerated renal function decline in the general population. (2010) de Jong, P. E., Stolk, R. P., and Gansevoort, R. T. Krikken, J. A. Metabolic aspects of dietary sodium restriction as a therapeutic intervention. (2010) Navis, G. J., Dullaert, R. P. F., and Bakker, S. J. L. Mahmoodi, B. K. Thromboembolic disease of the venous and the arterial system : two different entities or two different sides of the same coin? (2010) Kluin-Nelemans, J. C., Navis, G. J., and Gansevoort, R. T. Rienstra, H. Chronic tissue remodeling in renal transplantation : studies on cell origin, proteoglycans, and response to intervention. (2010) Hillebrands, J. L., Navis, G. J., van Goor, H., and van den Born, J. Schilte, M. N. Anti-inflammatory therapy and biomarker analysis inperitoneal dialysis. (2010) van den Born, J. Voorham, J. Assessing cardiometabolic treatment quality in general practice. (2010) Haaijer-Ruskamp, F. M., Wolffenbuttel, B. H. R., and Denig, P. Journal articles Abbasi, A., Corpeleijn, E., Postmus, D., Gansevoort, R. T., de Jong, P. E., Gans, R. O. B., Struck, J., Hillege, H. L., Stolk, R. P., Navis, G., Bakker, S. J. L. Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome. Journal of Clinical Endocrinology & Metabolism 95(9): E26-E31, Alkhalaf, A., Bakker, S. J. L., Bilo, H. J. G., Gans, R. O. B., Navis, G. J., Postmus, D., Forsblom, C., Groop, P. H., Vionnet, N., Hadjadj, S., Marre, M., Parving, H. H., Rossing, P., Tarnow, L. A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus. Diabetologia 53(12): , Alkhalaf, A., Zurbig, P., Bakker, S. J. L., Bilo, H. J. G., Cerna, M., Fischer, C., Fuchs, S., Janssen, B., Medek, K., Mischak, H., Roob, J. M., Rossing, K., Rossing, P., Rychlik, I., Sourij, H., Tiran, B., Winklhofer-Roob, B. M., Navis, G. J. Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy. PLoS ONE 5(10 AR e13421 DI /journal.pone ) Alkhalaf, A., Klooster, A., van Oeveren, W., Achenbach, U., Kleefstra, N., Slingerland, R. J., Mijnhout, G. S., Bilo, H. J. G., Gans, R. O. B., Navis, G. J., Bakker, S. J. L. A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy. Diabetes Care 33(7): , Altorf-van Der Kuil, W., Engberink, M. F., Brink, E. J., van Baak, M. A., Bakker, S. J. L., Navis, G., van't Veer, P., Geleijnse, J. M. Dietary Protein and Blood Pressure: A Systematic Review. PLoS ONE 5(8 AR e12102 DI /journal.pone ) Antoniou, AC Antoniou Antonis C. 1, Wang, XS Wang Xianshu 2, Fredericksen, ZS Fredericksen Zachary S. 3, McGuffog, L McGuffog Lesley 1, Tarrell, R Tarrell Robert 3, Sinilnikova, OM Sinilnikova Olga M. 4 5, Healey, S Healey Sue 6, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nature Genetics 42(10): 885, 75 VARICK ST, 9TH FLR, NEW YORK, NY USA, NATURE PUBLISHING GROUP. Arsov, S., Graaff, R., Morariu, A. M., van Oeveren, W., Smit, A. J., Busletic, I., Trajcevska, L., Selim, G., Dzekova, P., Stegmayr, B., Sikole, A., Rakhorst, G. Does hepatitis C increase the accumulation of advanced glycation end products in haemodialysis patients? Nephrology Dialysis Transplantation 25(3): , Baigent, C., Landray, M., Reith, C., Dasgupta, T., Emberson, J., Herrington, W., Lewis, D., Mafham, M., Collins, R., Collins, R., Baigent, C., Landray, M., Bray, C., Chen, Y., Baxter, A., Young, A., Hill, M., Knott, C., Cass, A., Feldt-Rasmussen, B., Fellstrom, B., Grobbee, R., Gronhagen-Riska, C., Haas, M., Holdaas, H., Hooi, L. S., Jiang, L., Kasiske, B., Krairittichai, U., Levin, A., Massy, Z., Tesar, V., Walker, R., Wanner, C., Wheeler, D., Wiecek, A., Dasgupta, T., Lewis, D., Mafham, M., Majoni, W., Reith, C., Simpson, D., Strony, J., Musliner, T., Agodoa, L., Armitage, J., Chen, Z., Craig, J., de Zeeuw, D., Gaziano, M., Grimm, R., Krane, V., Neal, B., Ophascharoensuk, V., Pedersen, T., Sleight, P., Tobert, J., Tomson, C., Sandercock, P., Hill, C., Keech, A., Whelton, P., Yusuf, S., Peto, R., Emberson, J., Parish, S. Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering lowdensity lipoprotein cholesterol among 9,438 patients with 2

3 chronic kidney disease. American Heart Journal 160(5): 785- U28, Boersma, C., Gansevoort, R. T., Pechlivanoglou, P., Visser, S. T., van Toly, F. F. J., de Jong-van den Berg, de Jong, P. E., Postma, M. J. Screen-and-Treat Strategies for Albuminuria to Prevent Cardiovascular and Renal Disease: Cost-Effectiveness of Nationwide and Targeted Interventions Based on Analysis of Cohort Data From the Netherlands. Clinical Therapeutics 32(6): , Bouma, H. R., Ketelaar, M. E., Yard, B. A., Ploeg, R. J., Henning, R. H. Authors' Reply: AMP-Activated Protein Kinase as a Target for Preconditioning in Transplantation Medicine. Transplantation 90(11): 1242, Bouma, H. R., Strijkstra, A. M., Boerema, A. S., Deelman, L. E., Epema, A. H., Hut, R. A., Kroese, F. G. M., Henning, R. H. Blood cell dynamics during hibernation in the European Ground Squirrel. Veterinary Immunology and Immunopathology 136(3-4): , Bouma, H. R., Ketelaar, M. E., Yard, B. A., Ploeg, R. J., Henning, R. H. AMP-Activated Protein Kinase as a Target for Preconditioning in Transplantation Medicine. Transplantation 90(4): , Chambers, J. C., Zhang, W. H., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R., Deng, G. H., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X. J., Hedblad, B., van der Heide, J. J. H., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J. F., Luan, J., Luttropp, K., Marechal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A. J., Shuldiner, A. R., Sjogren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J. E., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M. R., Mooser, V., Abecasis, G. R., Lightstone, L., Scott, J., Navis, G., Elliott, P., Kooner, J. S. Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics 42(5): , Dallinga-Thie, G. M., Dullaart, R. P. F. Do genome-wide association scans provide additional information on the variation of plasma adiponectin concentrations? Atherosclerosis 208(2): , Damman, K., Voors, A. A., Hillege, H. L., Navis, G., Lechat, P., van Veldhuisen, D. J., Dargie, H. J. Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality. European Journal of Heart Failure 12(9): , Damman, K., van Veldhuisen, D. J., Navis, G., Vaidya, V. S., Smilde, T. D. J., Westenbrink, B. D., Bonventre, J. V., Voors, A. A., Hillege, H. L. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart 96(16): , de Borst, M. H., Navis, G. Dietary Salt Reductions and Cardiovascular Disease. New England Journal of Medicine 362(23): , de Jong, P. E., Gansevoort, R. T. Albuminuria in non-primary renal disease: risk marker rather than risk factor. Nephrology Dialysis Transplantation 25(3): , de Leeuw, K., van der Graaf, A. M., Bijzet, J., Stegeman, C. A., Smit, A. J., Kallenberg, C. G., Bijl, M. Patients with Wegener's granulomatosis: a long-term follow-up study. Clinical and Experimental Rheumatology 28(1): S18-S23, de Leeuw, K., Nienhuis, H., Smit, A., Stegeman, C., Kallenberg, C., Bijl, M. Increased accumulation of advanced glycation endproducts in patients with Wegener's granulomatosis. Annals of the Rheumatic Diseases 69(3): , de Zeeuw, D., Agarwal, R., Amdahl, M., Audhya, P., Coyne, D., Garimella, T., Parving, H. H., Pritchett, Y., Remuzzi, G., Ritz, E., Andress, D. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet 376(9752): , Dullaart, R. P. F., Horst-Schrivers, A. N. A., Koopmans, K. P. New imaging approaches to phaeochromocytomas and paragangliomas. Clinical Endocrinology 72(4): , Faas, M. M., van der Schaaf, G., Borghuis, T., Jongman, R. M., van Pampus, M. G., de Vos, P., van Goor, H., Bakker, W. W. Extracellular ATP induces albuminuria in pregnant rats. Nephrology Dialysis Transplantation 25(8): , Gansevoort, R. T., Nauta, F. L., Bakker, S. J. L. Albuminuria: all you need to predict outcomes in chronic kidney disease? Current Opinion in Nephrology and Hypertension 19(6): , Gansevoort, R. T., de Jong, P. E. Challenges for the present CKD classification system. Current Opinion in Nephrology and Hypertension 19(3): , Gross, S., van der Heide, J. J. H., van Son, W. J., Gans, R. O. B., Foell, D., Navis, G., Bakker, S. J. L. Body Mass Index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients. Medical Science Monitor 16(7): CR318-CR324, 3

4 Halbesma, N., Jansen, D. F., Stolk, R. P., de Jong, P. E., Gansevoort, R. T. Changes in renal risk factors versus renal function outcome during follow-up in a population-based cohort study. Nephrology Dialysis Transplantation 25(6): , Heerspink, H. J. L., Gansevoort, R. T., Brenner, B. M., Cooper, M. E., Parving, H. H., Shahinfar, S., de Zeeuw, D. Comparison of Different Measures of Urinary Protein Excretion for Prediction of Renal Events. Journal of the American Society of Nephrology 21(8): , Heerspink, H. J. L., de Zeeuw, D. Dual RAS Therapy Not on Target, but Fully Alive. Nephron Clinical Practice 116(2): C137-C142, Heerspink, H. J. L., de Zeeuw, D. Should Microalbuminuria Ever Be Considered as a Renal Endpoint in Any Clinical Trial? American Journal of Nephrology 31(5): , Heerspink, H. L., de Zeeuw, D. Composite renal endpoints: was ACCOMPLISH accomplished? Lancet 375(9721): , Hellemons, M. E., Bakker, S. J. L. Vitamin D as an accelerator of atherosclerotic calcification: a D-tail that may be a Trojan horse. Diabetologia 53(12): 2688, Ikram, M. K., Xueling, S., Jensen, R. A., Cotch, M. F., Hewitt, A. W., Ikram, M. A., Wang, J. J., Klein, R., Klein, B. E. K., Breteler, M. M. B., Cheung, N., Liew, G., Mitchell, P., Uitterlinden, A. G., Rivadeneira, F., Hofman, A., de Jong, P. T. V. M., van Duijn, C. M., Kao, L., Cheng, C. Y., Smith, A. V., Glazer, N. L., Lumley, T., McKnight, B., Psaty, B. M., Jonasson, F., Eiriksdottir, G., Aspelund, T., Harris, T. B., Launer, L. J., Taylor, K. D., Li, X. H., Iyengar, S. K., Xi, Q. S., Sivakumaran, T. A., Mackey, D. A., MacGregor, S., Martin, N. G., Young, T. L., Bis, J. C., Wiggins, K. L., Heckbert, S. R., Hammond, C. J., Andrew, T., Fahy, S., Attia, J., Holliday, E. G., Scott, R. J., Islam, F. M. A., Rotter, J. I., McAuley, A. K., Boerwinkle, E., Tai, E. S., Gudnason, V., Siscovick, D. S., Vingerling, J. R., Wong, T. Y. Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo. PLoS Genetics 6(10) Jun, M., Heerspink, H. J. L., Ninomiya, T., Gallagher, M., Bellomo, R., Myburgh, J., Finfer, S., Palevsky, P. M., Kellum, J. A., Perkovic, V., Cass, A. Intensities of Renal Replacement Therapy in Acute Kidney Injury: A Systematic Review and Meta-Analysis. Clinical Journal of the American Society of Nephrology 5(6): , Kamilic, J., Hamming, I., Kreutz, R., Bolbrinker, J., Siems, W. E., Nassar, I., Sluimer, J. C., Walther, T., Navis, G. J., van Goor, H. Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27. Hypertension Research 33(2): , Kok, R. J., Henning, R. H. Drug targeting to the kidney Preface. Advanced Drug Delivery Reviews 62(14): , Krikken, J. A., Gansevoort, R. T., Dullaart, R. P. F. Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease. Journal of Lipid Research 51(7): , Krikken, J. A., van Ree, R. M., Klooster, A., Seelen, M. A., Borghuis, T., Lems, S. P. M., Schouten, J. P., Bakker, W. W., Gans, R. O. B., Navis, G., Bakker, S. J. L. High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients. Transplant International 23(8): , Lely, A. T., Heerspink, H. J. L., Zuurman, M., Visser, F. W., Kocks, M. J. A., Boomsma, F., Navis, G. Response to angiotensin-converting enzyme inhibition is selectively blunted by high sodium in angiotensin-converting enzyme DD genotype: evidence for geneenvironment interaction in healthy volunteers. Journal of Hypertension 28(12): , Linssen, G. C. M., Bakker, S. J. L., Voors, A. A., Gansevoort, R. T., Hillege, H. L., de Jong, P. E., van Veldhuisen, D. J., Gans, R. O. B., de Zeeuw, D. N-terminal pro-b-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population. European Heart Journal 31(1): , Linssen, G. C. M., Damman, K., Hillege, H. L., van Veldhuisen, D. J., Voors, A. A., Navis, G. Letter by van Kimmenade et al Regarding Article, "Urinary N-Terminal Prohormone Brain Natriuretic Peptide Excretion in Patients With Chronic Heart Failure" Response. Circulation 121(10): E243, Loureiro, J., Schilte, M., Aguilera, A., bar-vizcaino, P., Ramirez- Huesca, M., Perez-Lozano, M. L., Gonzalez-Mateo, G., Aroeira, L. S., Selgas, R., Mendoza, L., Ortiz, A., Ruiz-Ortega, M., van den Born, J., Beelen, R. H. J., Lopez-Cabrera, M. BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure. Nephrology Dialysis Transplantation 25(4): , Maahs, D. M., Siwy, J., Argiles, A., Cerna, M., Delles, C., Dominiczak, A. F., Gayrard, N., Iphofer, A., Jansch, L., Jerums, G., Medek, K., Mischak, H., Navis, G. J., Roob, J. M., Rossing, K., Rossing, P., Rychlik, I., Schiffer, E., Schmieder, R. E., Wascher, T. C., Winklhofer-Roob, B. M., Zimmerli, L. U., Zurbig, P., Snell- Bergeon, J. K. Urinary Collagen Fragments Are Significantly Altered in Diabetes: A Link to Pathophysiology. PLoS ONE 5(9 AR e13051 DI /journal.pone ) Martens, H. A., Gross, S., van der Steege, G., Brouwer, E., Berden, J. H. M., de Sevaux, R., Derksen, R. H. W. M., Voskuyl, A. E., Berger, S. P., Navis, G. J., Kallenberg, C. G. M., Bijl, M. Lack of Association of C-C Chemokine Receptor 5 Delta 32 Deletion Status with Rheumatoid Arthritis, Systemic Lupus Erythematosus, Lupus Nephritis, and Disease Severity. Journal of Rheumatology 37(11): , Martirosya, L., Voorham, J., Haaijer-Ruskamp, F. M., Braspenning, J., Wolffenbuttel, B. H. R., Denig, P. A systematic literature review: 4

5 prescribing indicators related to type 2 diabetes mellitus and cardiovascular risk management. Pharmacoepidemiology and Drug Safety 19(4): , Matsushita, K., van der Velde, M., Astor, B. C., Woodward, M., Levey, A. S., de Jong, P. E., Coresh, J., Gansevoort, R. T. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 375(9731): , Meijer, E., Rook, M., Tent, H., Navis, G., van der Jagt, E. J., de Jong, P. E., Gansevoort, R. T. Early Renal Abnormalities in Autosomal Dominant Polycystic Kidney Disease. Clinical Journal of the American Society of Nephrology 5(6): , Meijer, E., de Jong, P. E., Gansevoort, R. T. Vasopressin and microalbuminuria: is it vasopressin per se or is it salt intake? Kidney International 77(9): , Meijer, E., Boertien, W. E., Nauta, F. L., Bakker, S. J. L., van Oeveren, W., Rook, M., van der Jagt, E. J., van Goor, H., Peters, D. J. M., Navis, G., de Jong, P. E., Gansevoort, R. T. Association of Urinary Biomarkers With Disease Severity in Patients With Autosomal Dominant Polycystic Kidney Disease: A Crosssectional Analysis. American Journal of Kidney Diseases 56(5): , Meijer, E., Bakker, S. J. L., Halbesma, N., de Jong, P. E., Struck, J., Gansevoort, R. T. Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort. Kidney International 77(1): 29-36, Mooyaart, A. L., Zutinic, A., Bakker, S. J. L., Grootendorst, D. C., Kleefstra, N., van Valkengoed, I. G. M., Bohringer, S., Bilo, H. J. G., Dekker, F. W., Bruijn, J. A., Navis, G., Janssen, B., Baelde, H. J., de Heer, E. Association Between CNDP1 Genotype and Diabetic Nephropathy Is Sex Specific. Diabetes 59(6): , Mulder, G. M., Nijboer, W. N., Seelen, M. A., Sandovici, M., Bos, E. M., Melenhorst, W. B. W. H., Trzpis, M., Kloosterhuis, N. J., Visser, L., Henning, R. H., Leuvenink, H. G. D., Ploeg, R. J., Sunnarborg, S. W., van Goori, H. Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury. Journal of Pathology 221(2): , Navis, G., Bakker, S. J. L., van der Harst, P. Dissecting the genetics of complex traits: lessons from hypertension(*). Nephrology Dialysis Transplantation 25(5): , Nienhuis, H. L. A., de Leeuw, K., Bijzet, J., van Doormaal, J. J., van Roon, A. M., Smit, A. J., Graaff, R., Kallenberg, C. G. M., Bijl, M. Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness. Arthritis Research & Therapy 12(5 AR R181 DI /ar3145) Nijboer, W. N., Ottens, P. J., van Dijk, A., van Goor, H., Ploeg, R. J., Leuvenink, H. G. D. Donor pretreatment with carbamylated erythropoietin in a brain death model reduces inflammation more effectively than erythropoietin while preserving renal function. Critical Care Medicine 38(4): , Noordzij, M. J., Lefrandt, J. D., Graaff, R., Smit, A. J. Skin Autofluorescence and Glycemic Variability. Diabetes Technology & Therapeutics 12(7): , Ocak, G., Verduijn, M., Vossen, C. Y., Lijfering, W. M., Dekker, F. W., Rosendaal, F. R., Gansevoort, R. T., Mahmoodi, B. K. Chronic kidney disease stages 1-3 increase the risk of venous thrombosis 30. Journal of Thrombosis and Haemostasis 8(11): , Ochodnicky, P., Henning, R. H., Buikema, H. J., de Zeeuw, D., Provoost, A. P., van Dokkum, R. P. E. Renal vascular dysfunction precedes the development of renal damage in the hypertensive Fawn-Hooded rat. American Journal of Physiology-Renal Physiology 298(3): F625-F633, Odden, M. C., Tager, I. B., Gansevoort, R. T., Bakker, S. J. L., Katz, R., Fried, L. F., Newman, A. B., Canada, R. B., Harris, T., Sarnak, M. J., Siscovick, D., Shlipak, M. G. Age and cystatin C in healthy adults: a collaborative study. Nephrology Dialysis Transplantation 25(2): , Ozyilmaz, A., Bakker, S. J. L., de Zeeuw, D., de Jong, P. E., Gansevoort, R. T. Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factors. Nephrology Dialysis Transplantation 25(11): , Padmanabhan, S., Melander, O., Johnson, T., Di Blasio, A. M., Lee, W. K., Gentilini, D., Hastie, C. E., Menni, C., Monti, M. C., Delles, C., Laing, S., Corso, B., Navis, G., Kwakernaak, A. J., van der Harst, P., Bochud, M., Maillard, M., Burnier, M., Hedner, T., Kjeldsen, S., Wahlstrand, B., Sjogren, M., Fava, C., Montagnana, M., Danese, E., Torffvit, O., Hedblad, B., Snieder, H., Connell, J. M. C., Brown, M., Samani, N. J., Farrall, M., Cesana, G., Mancia, G., Signorini, S., Grassi, G., Eyheramendy, S., Wichmann, H. E., Laan, M., Strachan, D. P., Sever, P., Shields, D. C., Stanton, A., Vollenweider, P., Teumer, A., Volzke, H., Rettig, R., Newton-Cheh, C., Arora, P., Zhang, F., Soranzo, N., Spector, T. D., Lucas, G., Kathiresan, S., Siscovick, D. S., Luan, J. A., Loos, R. J. F., Wareham, N. J., Penninx, B. W., Nolte, I. M., McBride, M., Miller, W. H., Nicklin, S. A., Baker, A. H., Graham, D., McDonald, R. A., Pell, J. P., Sattar, N., Welsh, P., Munroe, P., Caulfield, M. J., Zanchetti, A., Dominiczak, A. F. Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension. PLoS Genetics 6(10 AR e DI /journal.pgen ) Riedl, E., Koeppel, H., Pfister, F., Peters, V., Sauerhoefer, S., Sternik, P., Brinkkoetter, P., Zentgraf, H., Navis, G., Henning, R. H., van den Born, J., Bakker, S. J. L., Janssen, B., van der Woude, F. J., Yard, B. A. N-Glycosylation of Carnosinase Influences Protein Secretion and 5

6 Enzyme Activity Implications for Hyperglycemia. Diabetes 59(8): , Rienstra, H., Katta, K., Celie, J. W. A. M., van Goor, H., Navis, G., van den Born, J., Hillebrands, J. L. Differential Expression of Proteoglycans in Tissue Remodeling and Lymphangiogenesis after Experimental Renal Transplantation in Rats. PLoS ONE 5(2 AR e9095 DI /journal.pone ): e9095, Sandovici, M., Deelman, L. E., Benigni, A., Henning, R. H. Towards graft-specific immune suppression: Gene therapy of the transplanted kidney. Advanced Drug Delivery Reviews 62(14): , Sarwar, N., Gao, P., Seshasai, S. R. K., Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D. A., Selvin, E., Stampfer, M., Stehouwer, C. D. A., Lewington, S., Pennells, L., Thompson, A., Sattar, N., White, I. R., Ray, K. K., Danesh, J. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375(9733): , Schilte, M. 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7 Tabara, Y., Kohara, K., Kita, Y., Hirawa, N., Katsuya, T., Ohkubo, T., Hiura, Y., Tajima, A., Morisaki, T., Miyata, T., Nakayama, T., Takashima, N., Nakura, J., Kawamoto, R., Takahashi, N., Hata, A., Soma, M., Imai, Y., Kokubo, Y., Okamura, T., Tomoike, H., Iwai, N., Ogihara, T., Inoue, I., Tokunaga, K., Johnson, T., Caulfield, M., Munroe, P., Umemura, S., Ueshima, H., Miki, T. Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension The Japanese Millennium Genome Project. Hypertension 56(5): 973-U533, Tent, H., Rook, M., Stevens, L. A., van Son, W. J., van Pelt, L. J., Hofker, H. S., Ploeg, R. J., van der Heide, J. J. H., Navis, G. Renal Function Equations before and after Living Kidney Donation: A Within-Individual Comparison of Performance at Different Levels of Renal Function. Clinical Journal of the American Society of Nephrology 5(11): , Ulu, N., Gurdal, H., Landheer, S. W., Duin, M., Guc, M. O., Buikema, H., Henning, R. H. alpha(1)-adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor. British Journal of Pharmacology 161(6): , van der Harst, P., Bakker, S. J. L., de Boer, R. A., Wolffenbuttel, B. H. R., Johnson, T., Caulfield, M. J., Navis, G. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Human Molecular Genetics 19(2): , van der Velde, M., Bakker, S. J. L., de Jong, P. E., Gansevoort, R. T. Influence of Age and Measure of egfr on the Association between Renal Function and Cardiovascular Events. Clinical Journal of the American Society of Nephrology 5(11): , Voorham, J., Haaijer-Ruskamp, F. M., van der Meer, K., de Zeeuw, D., Wolffenbuttel, B. H. R., Hoogenberg, K., Denig, P. Identifying targets to improve treatment in type 2 diabetes; the Groningen Initiative to analyse Type 2 diabetes Treatment (GIANTT) observational study. Pharmacoepidemiology and Drug Safety 19(10): , Voorham, J., Haaijer-Ruskamp, F. M., Wolffenbuttel, B. H. R., Stolk, R. P., Denig, P. Cardiometabolic treatment decisions in patients with type 2 diabetes: the role of repeated measurements and medication burden. Quality & Safety in Health Care 19(5): , Voorham, J., Haaijer-Ruskamp, F. M., van der Meer, K., de Zeeuw, D., Wolffenbuttel, B. H. R., Hoogenberg, K., Denig, P. Quality of type 2 diabetes treatment: Results of the Giantt Project Nederlands Tijdschrift voor Geneeskunde 154(4): , Waanders, F., van Timmeren, M. M., Stegeman, C. A., Bakker, S. J. L., van Goor, H. Kidney injury molecule-1 in renal disease. Journal of Pathology 220(1): 7-16, Waanders, F., Navis, G., van Goor, H. Urinary Tubular Biomarkers of Kidney Damage: Potential Value in Clinical Practice. American Journal of Kidney Diseases 55(5): , Zelle, D. M., Corpeleijn, E., van Ree, R. M., Stolk, R. P., van der Veer, E., Gans, R. O. B., van der Heide, J. J. H., Navis, G., Bakker, S. J. L. Markers of the Hepatic Component of the Metabolic Syndrome as Predictors of Mortality in Renal Transplant Recipients. American Journal of Transplantation 10(1): , van der Velde, M., de Jong, P. E., Gansevoort, R. T. Comparison of the yield of different screening approaches to detect chronic kidney disease. Nephrology Dialysis Transplantation 25(10): , van Ree, R. M., Gross, S., Zelle, D. M., van der Heide, J. J. H., Schouten, J. P., van Son, W. J., Gans, R. O. B., Bakker, S. J. L. Influence of C-Reactive Protein and Urinary Protein Excretion on Prediction of Graft Failure and Mortality by Serum Albumin in Renal Transplant Recipients. Transplantation 89(10): , Vogt, L., Chiurchiu, C., Chadha-Boreham, H., Danaietash, P., Dingemanse, J., Hadjadj, S., Krum, H., Navis, G., Neuhart, E., Parvanova, A. I., Ruggenenti, P., Woittiez, A. J., Zimlichman, R., Remuzzi, G., de Zeeuw, D. Effect of the Urotensin Receptor Antagonist Palosuran in Hypertensive Patients With Type 2 Diabetic Nephropathy. Hypertension 55(5): , Vogt, L., Laverman, G. D., Navis, G. Time for a comeback of NSAIDs in proteinuric chronic kidney disease? Netherlands Journal of Medicine 68(12): , 7

8 CARDIOVASCULAIR CENTER - CVC Dissertations Ahmed, S. An update on amiodarone treatment for atrial fibrillation: efficacy versus safety. (2010) van Gelder, I. C., van Veldhuisen, D. J., and Links, T. P. Belonje, A. M. S. Endogenous and exogenous erythropoietin in left ventricular dysfunction. (2010) van Veldhuisen, D. J., van Gilst, W. H., and Voors, A. A. Kuipers, I. Liver X receptor in the cardiovascular system. (2010) van Gilst, W. H., van Veldhuisen, D. J., and de Boer, R. A. Loon, R. L. E. van. Paediatric pulmonary hypertension: epidemiology, characterisation and treatment. (2010) Berger, R. M. F., Hillege, H. L., and Mulder, B. J. M. Oeseburg, H. Cardiovascular Diseases. (2010) van Gilst, W. H., Silljé, H. W., de Boer, R. A., and van der Harst, P. Veeger, N. J. G. M. Individual approach towards optimal oral anticoagulation. (2010) Kluin-Nelemans, J. C. and Hillege, J. L. Liu, G. Genetic and environmental effects on obesity and insulin resistance : findings in youth. (2010) Snieder, H. Journal articles Aalberts, J. J. J., Schuurman, A. G., Pals, G., Hamel, B. J. C., Bosman, G., Hilhorst-Hofstee, Y., Barge-Schaapveld, D. Q. C. M., Mulder, B. J. M., van den Berg, M. P., van Tintelen, J. P. Recurrent and founder mutations in the Netherlands Extensive clinical variability in Marfan syndrome patients with a single novel recurrent fibrillin-1 missense mutation. Netherlands Heart Journal 18(2): 85-89, Abbasi, A., Corpeleijn, E., Postmus, D., Gansevoort, R. T., de Jong, P. E., Gans, R. O. B., Struck, J., Hillege, H. L., Stolk, R. P., Navis, G., Bakker, S. J. L. Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome. Journal of Clinical Endocrinology & Metabolism 95(9): E26-E31, Ahmed, S., Ranchor, A. V., Crijns, H. J. G. M., van Veldhuisen, D. J., van Gelder, I. C. Effect of continuous versus episodic amiodarone treatment on quality of life in persistent atrial fibrillation. Europace 12(6): , Arrigoni, S. C., Mecozzi, G., Zijlstra, F., Mariani, M. A. Aortic No- Touch Off-Pump Coronary Artery Bypass Grafting: A State-ofthe-Art Surgical Technique Reply. Annals of Thoracic Surgery 90(4): , Bardy, G. H., Smith, W. M., Hood, M. A., Crozier, I. G., Melton, I. C., Jordaens, L., Theuns, D., Park, R. E., Wright, D. J., Connelly, D. T., Fynn, S. P., Murgatroyd, F. D., Sperzel, J., Neuzner, J., Spitzer, S. G., Ardashev, A. V., Oduro, A., Boersma, L., Maass, A. H., van Gelder, I. C., Wilde, A. A., van Dessel, P. F., Knops, R. E., Barr, C. S., Lupo, P., Cappato, R., Grace, A. A. An Entirely Subcutaneous Implantable Cardioverter-Defibrillator. New England Journal of Medicine 363(1): 36-44, Beijk, M. A. M., Boekholdt, S. M., Rittersma, S. Z. H., Pons, D., Zwinderman, A. H., Doevendans, P. A. F., Tio, R. A., Tijssen, J. G. P., Jukema, J. W., de Winter, R. J. Toll-like receptor 4 gene polymorphisms show no association with the risk of clinical or angiographic restenosis after percutaneous coronary intervention. Pharmacogenetics and Genomics 20(9): , Bell, K. J. L., Hayen, A., Macaskill, P., Craig, J. C., Neal, B. C., Fox, K. M., Remme, W. J., Asselbergs, F. W., van Gilst, W. H., MacMahon, S., Remuzzi, G., Ruggenenti, P., Teo, K. K., Irwig, L. Monitoring Initial Response to Angiotensin-Converting Enzyme Inhibitor-Based Regimens An Individual Patient Data Meta- Analysis From Randomized, Placebo-Controlled Trials. Hypertension 56(3): 533-U429, Belonje, A. M. S., Voors, A. A., van der Meer, P., Jaarsma, T., van Veldhuisen, D. J., van Gilst, W. H. Response to Letter Regarding Article, "Endogenous Erythropoietin and Outcome in Heart Failure". Circulation 122(10): E450, Belonje, A. M. S., Voors, A. A., van der Meer, P., van Gilst, W. H., Jaarsma, T., van Veldhuisen, D. J. Endogenous Erythropoietin and Outcome in Heart Failure. Circulation 121(2): , Bentley, J. P., Asselbergs, F. W., Coffey, C. S., Hebert, P. R., Moore, J. H., Hillege, H. L., van Gilst, W. H. Cardiovascular Risk Associated with Interactions among Polymorphisms in Genes from the Renin-Angiotensin, Bradykinin, and Fibrinolytic Systems. PLoS ONE 5(9 AR e12757 DI /journal.pone ) Berger, R. M. F., Beghetti, M., Galie, N., Gatzoulis, M. A., Granton, J., Lauer, A., Chiossi, E., Landzberg, M. Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: A subgroup analysis. International Journal of Cardiology 144(3): , 8

9 Boersma, C., Voors, A. A., Visser, S. T., de Jong-van den Berg, Postma, M. J. Cost Effectiveness of Angiotensin Receptor Blocker Monotherapy in Patients with Hypertension in the Netherlands A Comparative Analysis Using Clinical Trial and Drug Utilization Data. American Journal of Cardiovascular Drugs 10(1): 49-54, Bolling, M. C., Pas, H. H., de Visser, M., Aronica, E., Pfendner, E. G., van den Berg, M. P., Diercks, G. F. H., Suurmeijer, A. J. H., Jonkman, M. F. PLEC1 Mutations Underlie Adult-Onset Dilated Cardiomyopathy in Epidermolysis Bullosa Simplex with Muscular Dystrophy. Journal of Investigative Dermatology 130(4): , Bouma, W., van der Horst, I. C. C., Wijdh-den Hamer, I. J., Erasmus, M. E., Zijlstra, F., Mariani, M. A., Ebels, T. Chronic ischaemic mitral regurgitation. Current treatment results and new mechanism-based surgical approaches. European Journal of Cardio-Thoracic Surgery 37(1): , Bouma, W., Wijdh-den Hamer, I. J., van der Horst, I. C. C., Mariani, M. A. Repair of chronic ischemic mitral regurgitation with posterior leaflet extension Reply. European Journal of Cardio- Thoracic Surgery 38(4): , Bouma, W., Klinkenberg, T. J., van der Horst, I. C. C., Wijdh-den Hamer, I. J., Erasmus, M. E., Bijl, M., Suurmeijer, A. J. H., Zijlstra, F., Mariani, M. A. Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature. Journal of Cardiothoracic Surgery 5 AR 13 DI / : 13, Brugemann, J., Kampinga, G. A., Riezebos-Brilman, A., Stek, C. J., Edel, J. P., van der Bij, W., Sprenger, H. G., Zijlstra, F. Two donorrelated infections in a heart transplant recipient: One common, the other a tropical surprise. Journal of Heart and Lung Transplantation 29(12): , Brugemann, J., Edel, J. P., Zijlstra, F. Clinical cardiac rehabilitation. Nederlands Tijdschrift voor Geneeskunde 154(12): , Chambers, J. C., Zhang, W. H., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R., Deng, G. H., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X. J., Hedblad, B., van der Heide, J. J. H., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J. F., Luan, J., Luttropp, K., Marechal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A. J., Shuldiner, A. R., Sjogren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J. E., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M. R., Mooser, V., Abecasis, G. R., Lightstone, L., Scott, J., Navis, G., Elliott, P., Kooner, J. S. Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics 42(5): , Christiaans, I., Nannenberg, E. A., Dooijes, D., Jongbloed, R. J. E., Michels, M., Postema, P. G., Majoor-Krakauer, D., van den Wijngaard, A., Mannens, M. M. A. M., van Tintelen, J. P., van Langen, I. M., Wilde, A. A. M. Founder mutations in hypertrophic cardiomyopathy patients in the Netherlands. Netherlands Heart Journal 18(5): , Christiaans, I., Birnie, E., van Langen, I. M., Spaendonck-Zwarts, K. Y., van Tintelen, J. P., van den Berg, M. P., Atsma, D. E., Helderman-van den Enden, A. T. J. M., Pinto, Y. M., Hermans-van Ast, J. F., Bonsel, G. J., Wilde, A. A. M. The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening. European Heart Journal 31(7): , Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., Soranzo, N., Zhai, G. J., Valdes, A. M., Blackburn, H., Leach, I. M., de Boer, R. A., Goodall, A. H., Ouwehand, W., van Veldhuisen, D. J., van Gilst, W. H., Navis, G., Burton, P. R., Tobin, M. D., Hall, A. S., Thompson, J. R., Spector, T., Samani, N. J. Common variants near TERC are associated with mean telomere length. Nature Genetics 42(3): , Coronel, R., Langerveld, J., Boersma, L. V. A., Wever, E. F. D., Bon, L., van Dessel, P. F. H. M., Linnenbank, A. C., van Gilst, W. H., Ernst, S. M. P. G., Opthof, T., van Hemel, N. M. Left atrial pressure reduction for mitral stenosis reverses left atrial directiondependent conduction abnormalities. Cardiovascular Research 85(4): , Cotter, G., Voors, A. A., Weatherley, B. D., Pang, P. S., Teerlink, J. R., Filippatos, G., Ponikowski, P., Milo-Cotter, O., Dittrich, H., Teichman, S. L., Adams, K. F., Gheorghiade, M., Metra, M. Acute Heart Failure Clinical Drug Development: From Planning to Proof of Activity to Phase III. Cardiology 116(4): , Damman, K., Voors, A. A., Hillege, H. L., Navis, G., Lechat, P., van Veldhuisen, D. J., Dargie, H. J. Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality. European Journal of Heart Failure 12(9): , Damman, K., van Veldhuisen, D. J., Navis, G., Vaidya, V. S., Smilde, T. D. J., Westenbrink, B. D., Bonventre, J. V., Voors, A. A., Hillege, H. L. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart 96(16): , 9

10 Davenport, A., Anker, S. D., Mebazaa, A., Palazzuoli, A., Vescovo, G., Bellomo, R., Ponikowski, P., Anand, I., Aspromonte, N., Bagshaw, S., Berl, T., Bobek, I., Cruz, D. N., Daliento, L., Haapio, M., Hillege, H., House, A., Katz, N., Maisel, A., Mankad, S., McCullough, P., Ronco, F., Shaw, A., Sheinfeld, G., Soni, S., Zamperetti, N., Zanco, P., Ronco, C. ADQI 7: the clinical management of the Cardio-Renal syndromes: work group statements from the 7th ADQI consensus conference. Nephrology Dialysis Transplantation 25(7): , de Boer, M. J., Ottervanger, J. P., Suryapranata, H., Hoorntje, J. C. A., Dambrink, J. H. E., Gosselink, A. T. M., van't Hof, A. W. J., Zijlstra, F. Old Age and Outcome After Primary Angioplasty for Acute Myocardial Infarction. Journal of the American Geriatrics Society 58(5): , de Boer, R. A., Doehner, W., van der Horst, I. C. C., Anker, S. D., Babalis, D., Roughton, M., Coats, A. J., Flather, M. D., van Veldhuisen, D. J. 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A., Jaarsma, T., Zijlstra, F., van den Heuvel, A. F. Clinical correlates of arterial lactate levels in patients with ST-segment elevation myocardial infarction at admission: a descriptive study. Critical Care 14(5 AR R164 DI /cc9253) Vonk, W. I. M., Wijmenga, C., Berger, R., van de Sluis, B., Klomp, L. W. J. Cu,Zn Superoxide Dismutase Maturation and Activity Are Regulated by COMMD1. Journal of Biological Chemistry 285(37): , 16

17 Voors, A. A., van de Wal, R. M., Hartog, J. W. L., Vijn, R. G., Hummel, Y. M., Plokker, T. W. M., van Veldhuisen, D. J., Jaarsma, W. Effects of Eprosartan on Diastolic Function and Neurohormones in Patients with Hypertension and Diastolic Dysfunction. Cardiovascular Drugs and Therapy 24(1): 33-40, Voors, A. A., Belonje, A. M. S., Zijlstra, F., Hillege, H. L., Anker, S. D., Slart, R. H. J. A., Tio, R. A., Van't Hof, A., Jukema, J. W., Peels, H. O. J., Henriques, J. P. S., ten Berg, J. M., Vos, J., van Gilst, W. H., van Veldhuisen, D. J. A single dose of erythropoietin in STelevation myocardial infarction. European Heart Journal 31(21): , Voors, A. A., van Veldhuisen, D. J. Cardiorenal Effects of Recombinant Human Natriuretic Peptides. Journal of the American College of Cardiology 55(17): , Wang, X. L., Zhu, H. D., Snieder, H., Su, S. Y., Munn, D., Harshfield, G., Maria, B. L., Dong, Y. B., Treiber, F., Gutin, B., Shi, H. D. Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Medicine 8 AR 87 DI / Wang, Y., Qian, C., Roks, A. J. M., Westermann, D., Schumacher, S. M., Escher, F., Schoemaker, R. G., Reudelhuber, T. L., van Gilst, W. H., Schultheiss, H. P., Tschope, C., Walther, T. Circulating Rather Than Cardiac Angiotensin-(1-7) Stimulates Cardioprotection After Myocardial Infarction. Circulation-Heart Failure 3(2): , Westenbrink, B. D., Voors, A. A., de Boer, R. A., Schuringa, J. J., Klinkenberg, T., van der Harst, P., Vellenga, E., van Veldhuisen, D. J., van Gilst, W. H. Bone marrow dysfunction in chronic heart failure patients. European Journal of Heart Failure 12(7): , Westenbrink, B. D., Ruifrok, W. P. T., Voors, A. A., Tilton, R. G., van Veldhuisen, D. J., Schoemaker, R. G., van Gilst, W. H., de Boer, R. A. Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure. Cardiovascular Research 87(1): 30-39, Willemsen, S., Hartog, J. W. L., Hummel, Y. M., Posma, J. L., van Wijk, L. M., van Veldhuisen, D. J., Voors, A. A. Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial. European Journal of Heart Failure 12(3): , Winter, M. M., Reisma, C., Kedde, H., Bouma, B. J., Vis, J. C., Luijendijk, P., de Witte, P., Zwinderman, A. H., Vliegen, H. W., Pieper, P. G., van Dijk, A. P. J., Mulder, B. J. M. Sexuality in Adult Patients With Congenital Heart Disease and Their Partners. American Journal of Cardiology 106(8): , Wong, L. S. M., van der Harst, P., de Boer, R. A., Huzen, J., van Gilst, W. H., van Veldhuisen, D. J. Aging, telomeres and heart failure. Heart Failure Reviews 15(5): , Wong, L. S. M., Huzen, J., van der Harst, P., de Boer, R. A., Codd, V., Westenbrink, B. D., Benus, G. F. J. D., Voors, A. A., van Gilst, W. H., Samani, N. J., Jaarsma, T., van Veldhuisen, D. J. Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure. European Journal of Heart Failure 12(4): , Wu, T., Boezen, H. M., Postma, D. S., Los, H., Postmus, P. E., Snieder, H., Boomsma, D. I. Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins. European Respiratory Journal 36(2): , Wu, T., Snieder, H., de Geus, E. Genetic influences on cardiovascular stress reactivity. Neuroscience and Biobehavioral Reviews 35(1): 58-68, Yap, S. C., Drenthen, W., Pieper, P. G., Moons, P., Mulder, B. J. M., Vliegen, H. W., van Dijk, A. P. J., Meijboom, F. J., Jaddoe, V. W. V., Steegers, E. A. P., Boersma, E., Roos-Hesselink, J. W. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect. Bjog - an International Journal of Obstetrics and Gynaecology 117(6): , Zannad, F., McMurray, J. J. V., Drexler, H., Krum, H., van Veldhuisen, D. J., Swedberg, K., Shi, H., Vincent, J., Pitt, B. Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF). European Journal of Heart Failure 12(6): , 17

18 GRONINGEN RESEARCH INSTITUTE FOR ASTHMA AND COPD - GRIAC Dissertations Blacquière, M. J. Effects of environmental exposures on asthma phenotypes in the mouse : contributing and protecting mechanisms. (2010) Timens, W., Postma, D. S., and Hylkema, M. N. Bottema, R. W. B. Complex pathways to atopy development. Genes and environment. (2010) Postma, D. S., Schayck, C. P. van, and Kerkhof, M. Brouwer, A. F. J. Usefulness of home spirometry in childhood asthma. (2010) Duiverman, E. J. and Brand, P. L. P. Lapperre, T. S. Airway pathology in COPD; Smoking cessation and pharmacological treatment intervention. (2010) Timens, W Roscioni, S. S. Epac as a novel regulator of airway smooth muscle phenotype and function. Potential implications in asthma and COPD. (2010) Schmidt, M. and Meurs, H. Volbeda, F. The link of asthma outcome with AMP responsiveness and airway pathology. (2010) Postma, D. S., Timens, W., and ten Hacken, N. H. T. Dekkers, B. G. J. Major role of the extracellular matrix in airway smooth muscle phenotype plasticity. Implications for chronic asthma. (2010) Meurs, H. and Zaagsma, J. Journal articles Abello, N., Barroso, B., Kerstjens, H. A. M., Postma, D. S., Bischoff, R. Chemical labeling and enrichment of nitrotyrosine-containing peptides. Talanta 80(4): , Bergboer, J. G. M., Zeeuwen, P. L. J. M., Irvine, A. D., Weidinger, S., Giardina, E., Novelli, G., den Heijer, M., Rodriguez, E., Illig, T., Riveira-Munoz, E., Campbell, L. E., Tyson, J., Dannhauser, E. N., O'Regan, G. M., Galli, E., Klopp, N., Koppelman, G. H., Novak, N., Estivill, X., Mclean, W. H. I., Postma, D. S., Armour, J. A. L., Schalkwijk, J. Deletion of Late Cornified Envelope 3B and 3C Genes Is Not Associated with Atopic Dermatitis. Journal of Investigative Dermatology 130(8): , Birrell, M. A., van Oosterhout, A. J. M., Belvisi, M. G. Do the current house dust mite-driven models really mimic allergic asthma? European Respiratory Journal 36(5): , Blacquiere, M. J., Hylkema, M. N., Postma, D. S., Geerlings, M., Timens, W., Melgert, B. N. Airway Inflammation and Remodeling in Two Mouse Models of Asthma: Comparison of Males and Females. International Archives of Allergy and Immunology 153(2): , Blacquiere, M. J., Timens, W., van den Berg, A., Geerlings, M., Postma, D. S., Hylkema, M. N. Maternal smoking during pregnancy decreases Wnt signalling in neonatal mice. Thorax 65(6): , Bossenbroek, L., Kosse, N., ten Hacken, N., Gordijn, M., van der Hoeven, J., de Greef, M. VALIDATION OF THE DYNAPORT MINIMOD DURING SLEEP: A PILOT STUDY 3. Perceptual and Motor Skills 111(3): , Bottema, R. W. B., Nolte, I. M., Howard, T. D., Koppelman, G. H., Dubois, A. E. J., de Meer, G., Kerkhof, M., Bleecker, E. R., Meyers, D. A., Postma, D. S. Interleukin 13 and Interleukin 4 Receptoralpha Polymorphisms in Rhinitis and Asthma. International Archives of Allergy and Immunology 153(3): , Bottema, R. W. B., Kerkhof, M., Reijmerink, N. E., Koppelman, G. H., Thijs, C., Stelma, F. F., Smit, H. A., Brunekreef, B., van Schayck, C. P., Postma, D. S. X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. Allergy 65(7): , Bottema, R. W. B., Postma, D. S., Reijmerink, N. E., Thijs, C., Stelma, F. F., Simit, H. A., van Schayck, C. P., Brunekreef, B., Koppelman, G. H., Kerkhof, M. Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE. European Respiratory Journal 35(1): 54-63, Bottema, R. W. B., Kerkhof, M., Reijmerink, N. E., Thijs, C., Smit, H. A., van Schayck, C. P., Brunekreef, B., van Oosterhout, A. J., Postma, D. S., Koppelman, G. H. Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood. Journal of Allergy and Clinical Immunology 126(2): 338-U62, Bouzigon, E., Forabosco, P., Koppelman, G. H., Cookson, W. O. C. M., Dizier, M. H., Duffy, D. L., Evans, D. M., Ferreira, M. A. R., Kere, J., Laitinen, T., Malerba, G., Meyers, D. A., Moffatt, M., Martin, N. G., Ng, M. Y., Pignatti, P. F., Wjst, M., Kauffmann, F., Demenais, F., Lewis, C. M. Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics 18(6): , Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N., ten Hacken, N. H. T. Airway eosinophilia in remission and progression of asthma: 18

19 Accumulation with a fast decline of FEV1. Respiratory Medicine 104(9): , Brouwer, A. F. J., Brand, P. L. P., Roorda, R. J., Duiverman, E. J. Airway obstruction at time of symptoms prompting use of reliever therapy in children with asthma. Acta Paediatrica 99(6): , Brouwer, A. F. J., Visser, C. A. N., Duiverman, E. J., Roorda, R. J., Brand, P. L. P. Is Home Spirometry Useful in Diagnosing Asthma in Children With Nonspecific Respiratory Symptoms? Pediatric Pulmonology 45(4): , Budulac, S. E., Postma, D. S., Hiemstra, P. S., Kunz, L. I. Z., Siedlinski, M., Smit, H. A., Vonk, J. M., Rutgers, B., Timens, W., Boezen, H. M. Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Respiratory Research 11 AR 60 DI / : 60, Castro, M., Rubin, A. S., Laviolette, M., Fiterman, J., Lima, M. D., Shah, P. L., Fiss, E., Olivenstein, R., Thomson, N. C., Niven, R. M., Pavord, I. D., Simoff, M., Duhamel, D. R., McEvoy, C., Barbers, R., ten Hacken, N. H. T., Wechsler, M. E., Holmes, M., Phillips, M. J., Erzurum, S., Lunn, W., Israel, E., Jariour, N., Kraft, M., Shargill, N. S., Quiring, J., Berry, S. M., Cox, G. Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial. American Journal of Respiratory and Critical Care Medicine 181(2): , Caudri, D., Wijga, A. H., Hoekstra, M. O., Kerkhof, M., Koppelman, G. H., Brunekreef, B., Smit, H. A., de Jongste, J. C. Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. Thorax 65(9): , Cecchi, L., D'Amato, G., Ayres, J. G., Galan, C., Forastiere, F., Forsberg, B., Gerritsen, J., Nunes, C., Behrendt, H., Akdis, C., Dahl, R., Annesi-Maesano, I. Projections of the effects of climate change on allergic asthma: the contribution of aerobiology. Allergy 65(9): , Curjuric, I., Imboden, M., Schindler, C., Downs, S. H., Hersberger, M., Liu, S. L. J., Matyas, G., Russi, E. W., Schwartz, J., Thun, G. A., Postma, D. S., Rochat, T., Probst-Hensch, N. M. HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. European Respiratory Journal 35(3): , de Groot, E. P., Duiverman, E. J., Brand, P. L. P. Comorbidities of asthma during childhood: possibly important, yet poorly studied. European Respiratory Journal 36(3): , de Jong, N. W., van Maaren, M. S., Vlieg-Boersta, B. J., Dubois, A. E. J., De Groot, H., van Wijk, R. G. Sensitization to lupine flour: is it clinically relevant? Clinical and Experimental Allergy 40(10): , de Vries, T. W., van den Berg, P. B., Duiverman, E. J., de Jong-van den Berg. Effect of a minimal pharmacy intervention on improvement of adherence to asthma guidelines. Archives of Disease in Childhood 95(4): , Dekkers, B. G. J., Bos, I. S. T., Halayko, A. J., Zaagsma, J., Meurs, H. The laminin beta 1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma. Respiratory Research 11 Dekkers, B. G. J., Bos, I. S. T., Gosens, R., Halayko, A. J., Zaagsma, J., Meurs, H. The Integrin-blocking Peptide RGDS Inhibits Airway Smooth Muscle Remodeling in a Guinea Pig Model of Allergic Asthma. American Journal of Respiratory and Critical Care Medicine 181(6): , den Bakker, M. A., Willemsen, S., Grunberg, K., Noorduijn, L. A., van Oosterhout, M. F. M., van Suylen, R. J., Timens, W., Vrugt, B., Wiersma-van Tilburg, A., Thunnissen, F. B. J. M. Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology 56(3): , DunnGalvin, A., Cullinane, C., Daly, D. A., Flokstra-de Blok, B. M. J., Dubois, A. E. J., Hourihane, J. Longitudinal validity and responsiveness of the Food Allergy Quality of Life Questionnaire - Parent Form in children 0-12 years following positive and negative food challenges. Clinical and Experimental Allergy 40(3): , Eisner, M. D. A. An Official American Thoracic Society Public Policy Statement: Novel Risk Factors and the Global Burden of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine (5): , Flokstra-de Blok, B. M. J., van der Velde, J. L., Vlieg-Boerstra, B. J., Oude Elberink, J. N. G., DunnGalvin, A., Hourihane, J. O., Duiverman, E. J., Dubois, A. E. J. Health-related quality of life of food allergic patients measured with generic and disease-specific questionnaires. Allergy 65(8): , Flokstra-de Blok, B. M. J., Dubois, A. E. J., Vlieg-Boerstra, B. J., Elberink, J. N. G. O., Raat, H., DunnGalvin, A., Hourihane, J. O., Duiverman, E. J. Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy 65(2): , Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Magi, R., Chen, C. M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S., Bennett, A. J., Borja, J. B., Bouatia- Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A. L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hypponen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. 19

20 W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H. T., Zhao, J. H., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Smith, G. D., Power, C., Jaddoe, V. W. V., Jarvelin, M. R., McCarthy, M. I. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics 42(5): 430-U73, Gehring, U., Wijga, A. H., Brauer, M., Fischer, P., de Jongste, J. C., Kerkhof, M., Oldenwening, M., Smit, H. A., Brunekreef, B. Traffic-related Air Pollution and the Development of Asthma and Allergies during the First 8 Years of Life. American Journal of Respiratory and Critical Care Medicine 181(6): , Gosens, R., Baarsma, H. A., Heijink, I. H., Oenema, T. A., Halayko, A. J., Meurs, H., Schmidt, M. De novo synthesis of beta-catenin via H-Ras and MEK regulates airway smooth muscle growth. Faseb Journal 24(3): , Grandoch, M., Roscioni, S. S., Schmidt, M. The role of Epac proteins, novel camp mediators, in the regulation of immune, lung and neuronal function. British Journal of Pharmacology 159(2): , Halapi, E., Gudbjartsson, D. F., Jonsdottir, G. M., Bjornsdottir, U. S., Thorleifsson, G., Helgadottir, H., Williams, C., Koppelman, G. H., Heinzmann, A., Boezen, H. M., Jonasdottir, A., Blondal, T., Gudjonsson, S. A., Jonasdottir, A., Thorlacius, T., Henry, A. P., Altmueller, J., Krueger, M., Shin, H. D., Uh, S. T., Cheong, H. S., Jonsdottir, B., Ludviksson, B. R., Ludviksdottir, D., Gislason, D., Park, C. S., Deichmann, K., Thompson, P. J., Wjst, M., Hall, I. P., Postma, D. S., Gislason, T., Kong, A., Jonsdottir, I., Thorsteinsdottir, U., Stefansson, K. A sequence variant on 17q21 is associated with age at onset and severity of asthma. European Journal of Human Genetics 18(8): , Hartman, J. E., Boezen, H. M., de Greef, M. H. G., Bossenbroek, L., ten Hacken, N. H. T. Consequences of physical inactivity in chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 4(6): , Heijink, I. H., Postma, D. S., Noordhoek, J. A., Broekema, M., Kapus, A. House Dust Mite-Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium. American Journal of Respiratory Cell and Molecular Biology 42(1): 69-79, Heijink, I. H., van Oosterhout, A., Kapus, A. Epidermal growth factor receptor signalling contributes to house dust miteinduced epithelial barrier dysfunction. European Respiratory Journal 36(5): , Heijink, I. H., Brandenburg, S. M., Noordhoek, J. A., Postma, D. S., Slebos, D. J., van Oosterhout, A. J. M. Characterisation of cell adhesion in airway epithelial cell types using electric cellsubstrate impedance sensing. European Respiratory Journal 35(4): , Herth, F. J., Eberhard, R., Gompelmann, D., Slebos, D. J., Ernst, A. Bronchoscopic lung volume reduction with a dedicated coil: A clinical pilot study. Therapeutic Advances in Respiratory Disease 4(4): , Huismans, H. K., Douma, W. R., Kerstjens, H. A. M., Renkema, T. E. J. Asthma in Patients Climbing to High and Extreme Altitudes in the Tibetan Everest Region. Journal of Asthma 47(6): , Jansen, S. R., Van Ziel, A. M., Baarsma, H. A., Gosens, R. beta- Catenin regulates airway smooth muscle contraction. American Journal of Physiology-Lung Cellular and Molecular Physiology 299(2): L204-L214, Kerkhof, M., Postma, D. S., Brunekreef, B., Reijmerink, N. E., Wijga, A. H., de Jongste, J. C., Gehring, U., Koppelman, G. H. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax 65(8): , Kerstjens, H. A., Bjermer, L., Eriksson, L., Dahlstrom, K., Vestbo, J. Tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in moderate to severe COPD patients. Respiratory Medicine 104(9): , Kerstjens, H. A. M., ten Hacken, N. H. T. Uplifting results of tiotropium in moderate COPD (GOLD stage 2). Evidence-Based Medicine 15(2): 44-45, Kocks, J. W. H., Kerstjens, H. A. M., Snijders, S. L., de Vos, B., Biermann, J. J., van Hengel, P., Strijbos, J. H., Bosveld, H. E. P., van der Molen, T. Health status in routine clinical practice: validity of the clinical COPD questionnaire at the individual patient level. Health and Quality of Life Outcomes 8 AR 135 DI / Koster, E. S., Wijga, A. H., Zuidgeest, M. G. P., Belitser, S. V., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., Brunekreef, B., de Jongste, J. C., Maitland-van der Zee, A. H. Patterns of asthma medication use: early asthma therapy initiation and asthma outcomes at age 8. Pharmacoepidemiology and Drug Safety 19(10): , Koster, E. S., Wijga, A. H., Raaijmakers, J. A. M., Koppelman, G. H., Postma, D. S., Kerkhof, M., Hoekstra, M. O., de Jongste, J. C., Smit, H. A., Brunekreef, B., Maitland-van der Zee, A. H. High agreement between parental reported inhaled corticosteroid use and pharmacy prescription data. Pharmacoepidemiology and Drug Safety 19(11): , Lambrechts, D., Buysschaert, I., Zanen, P., Coolen, J., Lays, N., Cuppens, H., Groen, H. J. M., Dewever, W., van Klaveren, R. J., Verschakelen, J., Wijmenga, C., Postma, D. S., Decramer, M., Janssens, W. The 15q24/25 Susceptibility Variant for Lung 20