Arlington Innovation Center: Health Research (AIC:HR) Annual Report for the College of Science July 1, 2014 to June 30, 2015

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1 Faculty: Seong K. Mun, PhD, Director Kenneth H. Wong, PhD Alpay Özcan, PhD Shih-Chung Ben Lo, PhD Matthew Freedman, MD Arlington Innovation Center: Health Research (AIC:HR) Annual Report for the College of Science July 1, 2014 to June 30, 2015 A. Grants A.1. Active Grants P.I: Shih-Chung Ben Lo Title: Evaluation of Riverain ClearRead-CT-Insight for Assisting Radiologist in Lung Cancer Detection on Thoracic CT images Amount: $280,000 Sponsor: Riverain Technologies, LLC Period: 15-Feb-2015 to 14-May This is a project to test certain image processing software to improve the detectability of lung cancer nodules in CT images. RIVERAIN has developed a set of CT CAD algorithms and VIRGINA TECH is under a research contract to conduct a Machine Test and a Reader Performance Evaluation for the purpose of supporting RIVERAIN s FDA 510(K) application. The evaluation study involves radiologists reviewing set of images with and with processing. P.I. Seong K. Mun Title: Neuroperformance Imaging Amount: $1,498,000; Sponsor; U.S. Army Contract W23RYX1089N603 Perdiod: 1-May-2011 to 19-Sept-2015 This project is a collaborative effort between Virginia Tech, Washington University in St. Louis, and Gachon University in South Korea. The project focuses on the role of sleep in neuroperformance, with particular emphasis on (1) PET/MRI studies to understand dopamine, acetylcholine, and serotonin sleep regulatory systems in the brain, particularly in the brainstem and thalamus; (2) EEG/fMRI studies focusing on the functional connectivity of networks between the thalamus and cortex that control the

2 descent into sleep and are altered by sleep deprivation; (3) Development of reference image databases for high field MRI studies of the brain. We organized a Workshop at the Virginia Tech Research Center-Arlington on June 22-23, 2015, in order to review and develop a strategy for research on the effects of sleep and sleep disturbance as it related to mood and emotional stress responses in cognitive performance. A publication is forthcoming outlining the outcomes of the workshop. P.I.: Kenneth H. Wong, Title: Rugged Medic SmartPhone Amount: $1,357,023; Sponsor: Department of the Army Period: 30-Sep-2012 to 31-Dec-2015 This product is to develop a prototype mobile systems for the military medics triaging combat casualty. Project activity - Participated in C4ISR (Command, Control, Communications, Computers, Intelligence, Surveillance and Reconnaissance) Network Modernization E15 at Joint Base MDL in New Jersey. During this four week exercise, we integrated our medical smartphone technology with technology from other contractors and Army research and development entities such as Communications-Electronics Research, Development and Engineering Center (CERDEC) and Medical Communications for Combat Casualty Care (MC4). These technologies were then tested in a realistic field environment under simulated battlefield conditions. Simulated scenarios included checkpoint defense, convoy ambush, assault in forest and urban settings, and humanitarian missions in potentially hostile territory. All scenarios included ground ambulance and air ambulance casualty evacuation. Soldiers and medics led these exercises and provided daily feedback on technology usability, effectiveness, suitability and potential improvements. Simulations were also guided and observed by a team of expert evaluators. Our team brought rapid prototyping systems to this exercise and were able to work with air medics to design and feasibility-test a system for secure wireless audio communication with a medical smartphone inside a helicopter environment. The data gathered during this exercise will help to inform future fundamental research and pathways for translation of our research to a higher Technology Readiness Level (TRL). A NCTE has been received for this project through to December 31, Negotiation is underway for the Third year funding. P.I. Seong K. Mun, Title: Open Source Electronic Health Record Agent Amount: $346,140; Sponsor; Veterans Affairs/ OEHRA 2

3 Period: 15-Jun-2012 to 31-Dec-2015 As a continuation of a previous grant with Virginia Tech, the Department of Veterans Affairs (VA) is developing an electronic health record (EHR) Open Source ecosystem facilitated and guided by a central body, the Open Source EHR Alliance (OSEHRA). OSEHRA is a non-profit organization established by the Department of Veterans Affairs to promote the adoption of open source methodology for improving VistA software. Dr. Mun provides technical and management leadership of the program activities of OSEHRA. This project has also been extended with additional funding through to December 31, A.2. Submitted Grant Applications These applications were submitted during the reporting period and they were all funded as shown in Section A.1 Proposal Title: Funding Agency: Budget Total: Evaluation of Riverain ClearRead-CT-Insight for Assisting Radiologist in Lung Cancer Detection on Thoracic CT images Riverain Technologies, LLC $280,000 - Funded Proposal Title: Open Source Electronic Health Record Agent Option 4 Funding Agency: Veterans Affairs/Ray Group International Budget: $120,467 - Funded Proposal Title: Rugged Medic SmartPhone Option 1 Funding Agency: Department of the Army Budget: $857,981- Funded A.3. Annual Research Expenditures $1.063,239 B. Publications Alpay Özcan, Baris Türkbey, Peter Choyke, Oguz Akin, Ömer Aras and Seong K. Mun, Interactive Feature Space Explorer for Multi-Modal Magnetic Resonance Imaging, Magnetic Resonance Imaging, July 2015, Volume 33, Issue 6, Pages

4 C. Outreach & Talks Faculty affiliation with new interdisciplinary graduate program in Translational Biology, Medicine, and Health (Wong) Participated in Special Operations Medical Association (SOMA) Annual Meeting (Dec 2014) and presented on user experience, industrial design, and wireless communications for medical end user devices, during a session entitled Battlefield Medical Informatics Workshop (Wong) Hosted workshop at the Virginia Tech Research Center-Arlington on June 22-23, 2015, in order to review and develop a strategy for research on the effects of sleep and sleep disturbance as it related to mood and emotional stress responses in cognitive performance. A publication is forthcoming outlining the outcomes of the workshop (Mun) Recruited two summer undergraduate interns for imaging and sleep research projects (Mun) Development of collaboration with Dr. Ongur at McLean Hospital, a Harvard University affiliate, for applying the identification methods to depression, schizophrenia and bi-polar disorder (Özcan) Seminar: Healthcare Reform: An American Journey at Kyungbook National University Medical School, Korea, October 23, 2014 (Mun) Seminar: Open Source, A Case Study in Healthcare at Pohang Technical University (POSTECH), Korea, October 22, 2014 (Mun) Seminar: Thinking Anew for an Old Problem (of Research), Busan National University, Korea, June 30, 2014 (Mun) Invited Talk: Should Telemedicine Be Allowed in Korea?, Korean Health Informatics Society Fall Meeting, Busan, Korea, October 26, 2014 (Mun) Invited Talk: Mobile device for the Military and the First Responders, Health IT Workshop, Catholic University of Korea, October 30, 2014 (Mun) Presentation: Open Source Electronic Health Record, Computer Aided Radiology and Surgery Annual Conference, Japan, June 28, 2014 (Mun) Keynote: Open Source Electronic Health Records, IEEE Biomedical Engineering Summer School, Hong Kong, July 1,

5 D. Awards D. Key Strategic Development Activities for the Next Year Develop a collaborative graduate physics program between Blacksburg and Yonsei University in Seoul, Korea Participate in the developing international program at the National Capital Region in the areas of community-based entrepreneurship Expand research collaboration with Blacksburg in the area of image processing and wireless mobile technology Expand research collaboration with Department of Radiation Medicine of Georgetown University in the areas of clinical outcome research of prostate cancer. Seek potential research partners to compliment MedicPhone project. 5