(12) Oversettelse av europeisk patentskrift

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1 (12) Oversettelse av europeisk patentskrift (11) NO/EP B1 (19) NO NORGE (51) Int Cl. C12N 5/0784 ( ) A61K 45/00 ( ) A61P 35/00 ( ) Patentstyret (21) Oversettelse publisert (80) Dato for Den Europeiske Patentmyndighets publisering av det meddelte patentet: (86) Europeisk søknadsnr: (86) Europeisk innleveringsdag (87) Den europeiske søknadens Publiseringsdato (30) Prioritet GB (84) Utpekte stater AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (73) Innehaver CytoVac A/S, SCION-DTU Forskerparken Venlighedsvej Hørsholm, Danmark (72) Oppfinner KIRKIN, Alexei, Strandboulevarden 61, 2. tv2100 Copenhagen, Danmark DZHANDZHUGAZYAN, Karine, Strandboulevarden 61, 2. tv2100 Copenhagen, Danmark (74) Fullmektig Acapo AS, Postboks 1880 Nordnes, 5817 BERGEN, Norge (54) Benevnelse Anti-tumorvaksine avledet av normale kjemisk modifiserte CD4+-celler (56) Anførte publikasjoner WO-A-03/ B1, XIANG JIM ET AL: "A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells." JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUN 2005, vol. 174, no. 12, 15 June 2005 ( ), pages , XP ISSN: , CORAL SANDRA ET AL: "5-aza-2'-deoxycytidineinduced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications." CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AUG 2002, vol. 8, no. 8, August 2002 ( ), pages , XP ISSN: , GEIGER CHRISTIANE ET AL: "A generic RNA-pulsed dendritic cell vaccine strategy for renal cell carcinoma" JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 3, no. 1, 26 July 2005 ( ), page 29, XP ISSN: , GROEPER CÉLIA ET AL: "Cancer/testis antigen expression and specific cytotoxic T lymphocyte responses in non small cell lung cancer." INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 JAN 2007, vol. 120, no. 2, 25 October 2006 ( ), pages , XP ISSN: , GUO Z SHENG ET AL: "De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model." CANCER RESEARCH 15 JAN 2006, vol. 66, no. 2, 15 January 2006 ( ), pages , XP ISSN: , JANUCHOWSKI R ET AL: "Effect of hydralazine on CD3-zeta chain expression in Jurkat T cells." ADVANCES IN MEDICAL SCIENCES 2006, vol. 51, 2006, pages , XP ISSN: , KENNEDY RICHARD ET AL: "Direct cross-priming by th lymphocytes generates memory cytotoxic T cell responses." JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 APR 2005, vol. 174, no. 7, 1 April 2005 ( ), pages , XP ISSN: , KOZLOWSKA ANNA ET AL: "Effect of Trichostatin A on CD4 surface density in peripheral blood T cells." FOLIA HISTOCHEMICA ET CYTOBIOLOGICA / POLISH ACADEMY OF SCIENCES, POLISH HISTOCHEMICAL AND CYTOCHEMICAL SOCIETY 2006, vol. 44, no. 4, 2006, pages , XP ISSN: , LUISA NOVELLINO ET AL: "A listing of human tumor

4 (86) Europeisk innleveringsdag 2008.01.

2 antigens recognized by T cells: March 2004 update" CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER-VERLAG, BE, vol. 54, no. 3, 1 March 2005 ( ), pages , XP ISSN: , MCCURDY DEBORAH K ET AL: "Expression of melanoma antigen gene by cells from inflamed joints in juvenile rheumatoid arthritis." THE JOURNAL OF RHEUMATOLOGY OCT 2002, vol. 29, no. 10, October 2002 ( ), pages , XP ISSN: X, MOREIRA JOSÉ MANUEL AFONSO ET AL: "The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses." BMC CANCER 9 NOV 2003, vol. 3, 9 November 2003 ( ), page 30, XP ISSN: , NAOTA ET AL: "Generation of peptide-specific CD8<+> T cells by phytohemagglutininstimulated antigen-mrna-transduced CD4<+> T cells" JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 314, no. 1-2, 31 July 2006 ( ), pages 54-66, XP ISSN: , SAGALLER M L ET AL: "Generation od specific anti- melanoma reactivity by stimulation of human tumor- infiltrating lymphocytes with MAGE-1 synthetic peptide" CANCER IMMUNOLOGY AND IMMUNOTHERAPY, BERLIN, DE, vol. 39, no. 2, 1994, pages , XP ISSN: , SARMA S ET AL: "Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo." THE JOURNAL OF EXPERIMENTAL MEDICINE 1 MAR 1999, vol. 189, no. 5, 1 March 1999 ( ), pages , XP ISSN: , SHICHIJO S ET AL: "Induction of MAGE genes in lymphoid cells by the demethylating agent 5-aza-2'-deoxycytidine." JAPANESE JOURNAL OF CANCER RESEARCH : GANN JUL 1996, vol. 87, no. 7, July 1996 ( ), pages , XP ISSN: , SIGALOTTI L ET AL: "Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-Aza-2'-deoxycytidine" CANCER RESEARCH US, vol. 64, no. 24, 15 December 2004 ( ), pages , XP ISSN: , TOLDBOD- HE ET AL.: "Potent influence of bovine serum proteins in experimental dendritic cell-based vaccination protocols" SCAND J IMMUNOL., vol. 58, no. 1, July 2003 ( ), page 43-50,, VAN RIETSCHOTEN JOHANNA G I ET AL: "Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL- 1alpha in CD4+ T cells." BLOOD 1 OCT 2006, vol. 108, no. 7, 1 October 2006 ( ), pages , XP ISSN: , ADAMOPOULOU ELENI ET AL: "Human CD4+ T cells displaying viral epitopes elicit a functional virus-specific memory CD8+ T cell response." JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAY 2007, vol. 178, no. 9, 18 December 2006 ( ), pages , XP ISSN:

" THE JOURNAL OF RHEUMATOLOGY OCT 2002, vol. 29, no.

(12) Oversettelse av europeisk patentskrift

(12) Oversettelse av europeisk patentskrift (11) NO/EP 2294743 B1 (19) NO NORGE (51) Int Cl. H04L 1/16 (2006.01) H04L 1/18 (2006.01) Patentstyret (21) Oversettelse publisert 2012.12.10 (80) Dato for Den