CURRICULUM VITAE Valery Grinevich

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1 CURRICULUM VITAE Valery Grinevich Current address Current position Neuropeptide laboratory German Cancer Research Center DKFZ CellNetwork Claster, University of Heidleberg im Neuenheimer Feld 280 D Heidelberg, German Phone: Fax: Home page: Head, Group Leader Date of Birth June 16, 1969 Research Interests 1. Exploration of the functional connectivity of hypothalamic neurons and probing axonal neuropeptide release within the rodent forebrain by viral, optogenetic and fmri means. 2. Evaluation of the role of select genes, which regulate the activity of hypothalamic neurons controlling stress and fear responses as well as metabolic and reproductive functions by viral and transgenic approaches. Education Doctor of Medicine, Kursk State Medical University, Kursk, Russia Doctor of Philosophy, I.M.Sechenov Institute of Evolutionary Biochemistry and Physiology, Russian Academy of Sciences, Saint-Petersburg, Russia Doctor of Sciences (Habilitation), Russian State Medical University, Moscow, Professional Experience 1995, Predoctoral training, Molecular Endocrinology, Laval University, Quebec, Canada , Researcher, National Endocrinology Center, Moscow, Russia.

2 , Visiting Fellow, Section on Endocrine Physiology, NICHD, NIH, Bethesda, USA , Alexander von Humboldt Research Fellow, Department of Anatomy II, Friedrich Schiller University, Jena, Germany , Lecturer, Department of Histology and Embryology, Russian State Medical University, Moscow, Russia , Postdoctoral Fellow, Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany , Postdoctoral Fellow, Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL July 2008-present, Group Leader, Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany From February 1 st, 2012 Head, Chica and Heinz Schaller Research Group, the University of Heidelberg and the German Cancer Research Center, Heidelberg, Germany Professional Activities / Awards Chica and Heinz Schaller Foundation award for establishing and conductance of the new laboratory affiliated at the Heidelberg University and the German Cancer Research Center (from February, 1 st 2012, for five years with possible prolongation and tenure). Alexander von Humboldt Research Fellowship, Germany ( ) International Research Fellowship, NIH, USA ( ) Award of European Academy (Academia Europea) for Young Researchers, Prize in Medicine (1998) Russian Presidentʼs Stipend Award for research training abroad (1995) Member, Society for Neuroscience (2005 present) Review Reviewer of manuscripts for: The Journal of Comparative Neurology, European Journal of Neuroscience, Neuroendocrinology, Frontiers in Neuroendocrinology, Hormone and Metabolic Research, Cellular and Molecular Neurobiology 2

3 Reviewer of grant applications for: Welcome Trust Research Grants and Support Chica and Heinz Schaller Foundation award for establishing and conductance of the new laboratory affiliated at the Heidelberg University and the German Cancer Research Center (July, 2011). German Research Foundation (DFG) grant GR 3619/3-1 Oxytocin brain circuits in lactating rats. PI: Valery Grinevich ( ). German Research Foundation (DFG) grant GR 3619/2-1 Role of corticotropinreleasing hormone in stress-induced inhibition of the hypothalamic-pituitary-gonadal axis. PI: Valery Grinevich ( ). Swiss National Research Foundation grant In vitro and in vivo effects of the fear response of optogenetically induced oxytocin release in the central amygdala. PI: Ron Stoop (Lausanne University, Switzerland). V. Grinevich is an external collaborator, officially sharing two PhD students with the PI ( ). German Research Foundation (DFG) grant BO 1958/6-1 The vasopressin V1a and V1b receptors in the medial preoptic area mediate maternal care in lactating rats. PI: Oliver Bosch (Regensburg University, Germany). V. Grinevich is an external collaborator ( ). NIH grant, R21 MH Pharmacogenetic tool for the manipulation of functional brain connectivity. PIs: Joshua A. Gordon (New York State Psychiatric Institute, USA), Cornelius T. Gross (EMBL Monterotondo, Italy). V Grinevich is an external collaborator ( ). Alexander von Humboldt Research Grant/Fellowship, Germany ( ). Recipient: V. Grinevich, host: Prof. Jirikowski, Friedrich Schiller University, Jena, Germany. NATO Collaborative Research Grant #SA (CRG )144/97/AHJ-501 ( ). PIs: Greti Aguilera and Valery Grinevich. Grants of Russian Foundation for Fundamental Research # ( ). PIs: Valery Grinevich and Ildar Akmayev (National Endocrinology Research Center, Moscow, Russia). Invited Seminars (Research Departments) Weizmann Institute of Science, Rehovot, Israel (2012) School of Biomedical Sciences, University of Edinburgh, Edinburgh (2012) Cold Spring Harbor Laboratories, New York (2011) The Central Institute of Mental Health, Mannheim (2011) 3

4 Interdisciplinary Neuroscience Center, Heidelberg (2010) European Molecular Biology Laboratories (EMBL), Monterotondo (2010) Department of Psychiatry, Lausanne University (2010) INSERM, Bordeaux (January, 2010) NINDS, NIH, Bethesda (2009) NICHD, NIH, Bethesda (2009) Department of Behavioral Neuroendocrinology, University of Regensburg, Regensburg (2009, 2011) Max Planck Institute for Psychiatry, Munich (2008) Department of Biology, Groningen University (2004) Ivan Pavlov Institute of Physiology, Saint-Petersburg (2003) Department of Clinical Neurobiology, Heidelberg University (2002) Departments of Anatomy I and II, Jena University (2000) Developmental Endocrinology Branch, NICHD, NIH (1997) Invited Seminars (Meetings) 4th International Haifa Forum for Brain and Behavior and Molecular and Cellular Cognition Society meeting, February 5-7, Haifa, Israel (2012) 9 th World Congress on Neurohypophysial Hormones, July 27-30, Boston, USA (2011) 10 th Symposium on Catecholamines and other neurotransmitters in stress, June 25-30, Smolenice, Slovak Republic (2011) CHS Schaller Symposium, Heidelberg (2011) Christmas Symposiums SFB 488, Heidelberg (2009, 2010) Janelia Conference Can new tools revolutionize understanding of hypothalamic neural circuits?, October 25-28, Loudoun County, VA, USA (2009) Neuropeptides-2009, October 14-16, Chicago, IL, USA (2009) International Meeting of Pavlovian Society for Physiology, Moscow, Russia (2007) World Congress on Cell and Molecular Biology, Jena, Germany (2000). International Symposium of Society for Psychoneuroendocrinology, Novosibirsk, Russia (1999) The XXXIXth Symposium of the Society for Histochemistry, Jena, Germany (1997) Supervision of Studentʼs Thesis Miriam Kernert, master (diploma) thesis ( ): Anatomical heterogeneity of hypothalamic oxytocin neurons, studied by viral vectors-based techniques (Max Planck Institute for Medical Research; defended February 2012; highest rank). Sophie Koszinowski, master (diploma) thesis ( ): Connectivity of oxytocin and CRH neurons, evaluated by viral technique (Max Planck Institute for Medical Research, Heidelberg, Germany; shared with Prof. Dr. Inga Neumann, Regensburg University, Germany). Lena Hoffmann, doctoral thesis (2009 present): Transgenic and viral techniques for studying hypothalamic functions (Max Planck Institute for Medical Research, Heidelberg, Germany). 4

5 Sophie Knobloch, doctoral thesis (2008 present): Plasticity of oxytocinergic system in the rodent brain, evaluated by viral technique (Max Planck Institute for Medical Research, Heidelberg, Germany). Alexander V. Misharin (2004), doctoral thesis: Effects of the bacterial endotoxemia on vasopressin receptor type 2 aquaporin 2 system in the rat kidney (Russian State Medical University, Moscow, Russia). Alexei B. Resnenko (2004), doctoral thesis: Hypothalamic-pituitary-adrenal axis in rats subjected to chronic lipopolysaccharide administration (Russian State Medical University, Moscow, Russia). Elena V. Sivukhina (2004), doctoral thesis: Magnocellular hypothalamic nuclei in patients afflicted with chronic alcoholic disease (Kursk State Medical University, Kursk, Russia). Tatjana A. Ishunina (2001), doctoral thesis: Sex- and age-dependent differences in the supraoptic nucleus of the human hypothalamus (Kursk State Medical University, Kursk, Russia). Nadezhda A. Abramova (2000), master (diploma) thesis: Hypothalamic-pituitaryadrenal axis under chronic inflammation in rats (National Endocrinological Research Center, Moscow, Russia). V. Grinevich is a member of PhD thesis advisory committee at the MPImF, Heidelberg (2010 present) and the German Research Cancer Center (DKFZ), Heidelberg (2011 present). Teaching Experience Lecture for PhD students of the Max Planck Institute for Medical Reseach, March, Lecture for the International Elite Master Program Experimental and Clinical Neuroscience, Regensburg University, Regensburg, Germany, May, Lecture for PhD students, Neuroscience Program, Interdisciplinary Neuroscience Center, Heidelberg University, Heidelberg, Germany, November, Lecture for the International Elite Master Program Experimental and Clinical Neuroscience, Regensburg University, Regensburg, Germany, January, Lectures for the Courses of EUSynapse Consortium Virus-mediated gene delivery into the neonatal and adult mouse brain, Max-Planck-Institute for Medical Research, Heidelberg, Germany, September Lectures and seminars on Histology, Embryology, and Cell Biology, Pediatric Faculty, Russian State Medical University, Moscow, Russia,

6 Lectures on Integrative Medicine for senior and PhD students: Neuro-endocrineimmune interactions: basic research and clinical applications, Pediatric Faculty, Russian State Medical University, Moscow, Russia, Seminars on Comparative Neuroendocrinology, Biological Faculty, Saint-Petersburg State University, Russia,