*** PUBLICATIONS ***

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1 *** PUBLICATIONS *** Roger K. Schindhelm, MD PhD MEpi EuSpLM Specialist in Laboratory Medicine / Epidemiologist publications(at)schindhelm.nl Updated: July 11, 2015/ H-index 13 (10 years) PHD-THESIS Postprandial dysmetabolism and non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular risk. Amsterdam: VU University (defended May 21 st 2007). FULL PAPERS, REVIEWS AND LETTERS (key publications are shown in bold) 1. Schindhelm RK & Hospers HJ. Sex with men before coming-out: relation to sexual activity and sexual risk-taking behavior. Arch Sex Behav 2004;33(6): Schindhelm RK, Diamant M, Bakker SJ, Van Dijk RA, Scheffer PG, Teerlink T, Kostense PJ, Heine RJ. Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridemic subjects with type 2 diabetes mellitus. Eur J Clin Invest 2005;35(6): Schindhelm RK, Dekker JM, Nijpels G, Heine RJ, Diamant M. No independent association of alanine aminotransferase with risk of future type 2 diabetes in the Hoorn Study [letter]. Diabetes Care 2005;28(11): Schindhelm RK & Hospers HJ. Mannen die seks hebben met mannen vóór de coming-out: relatie met seksuele activiteit en seksueel risicogedrag [in Dutch]. Tijdschrift voor Seksuologie 2006;30(1): Schindhelm RK, Diamant M, Dekker JM, Tushuizen ME, Teerlink T, Heine RJ. Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease [review]. Diabetes Metab Res Rev 2006;22(6): Schindhelm RK, Heine RJ, Diamant M. Non-alcoholic fatty liver disease as a determinant of cardiovascular disease: response to Targher [letter]. Atherosclerosis 2007;190(1): Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ, Diamant M. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis 2007;191(2): [IF:4.287/2007] 8. Schindhelm RK, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ, Diamant M. Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study. Diabet Med 2007;24(4): Schindhelm RK, Diamant M, Heine RJ. Nonalcoholic fatty liver disease and cardiovascular disease risk [review]. Curr Diab Rep 2007;7(3): Schindhelm RK, Alssema M, Scheffer PG, Diamant M, Dekker JM, Barto R, Nijpels G, Kostense PJ, Heine RJ, Schalkwijk CG, Teerlink T. Fasting and postprandial glycoxidative and lipoxidative stress are increased in women with type 2 diabetes mellitus. Diabetes Care 2007;30(7): [IF:7.581/2007] 1

2 11. Schindhelm RK, Heine RJ, Diamant M. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients [letter]. Diabetes Care 2007;30(9):e94;author reply e Tushuizen ME, Bunck MC, Pouwels PJ, Bontemps S, Van Waesberghe JH, Schindhelm RK, Mari A, Heine RJ, Diamant M. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007;30(11): Erratum in: Diabetes Care 2008;31(4): Schindhelm RK, Alssema M, Diamant M, Teerlink T, Dekker JM, Kok A, Kostense PJ, Nijpels G, Heine RJ, Scheffer PG. Comparison of the effect of two consecutive fat-rich and carbohydrate rich meals on postprandial plasma myeloperoxidase in women with and without type 2 diabetes mellitus. Metabolism 2008;57(2): Alssema M, Schindhelm RK, Dekker JM, Diamant M, Kostense PJ, Teerlink T, Scheffer PG, Nijpels G, Heine RJ. Postprandial glucose and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn Prandial study. Atherosclerosis 2008;196(2): Schindhelm RK & Diamant M. Endothelial dysfunction in Turkish patients with non-alcoholic fatty liver disease [letter]. Intern Med J 2008;38(4): ;author reply Schindhelm RK & Diamant M. Niet-alcoholische leversteatose: een nieuwe cardiovasculaire risicofactor [review, in Dutch]? Ned Tijdschr Diabetologie 2008;6(2); Alssema M*, Schindhelm RK*, Dekker JM, Diamant M, Nijpels G, Teerlink T, Scheffer PG, Kostense PJ, Heine RJ. Determinants of postprandial triglyceride and glucose responses following two consecutive fat-rich or carbohydrate-rich meals in normoglycemic women and women with type 2 diabetes mellitus: the Hoorn Prandial study. Metabolism 2008;57(9): [*both authors contributed equally]. 18. Schindhelm RK, Diamant M, Bilo HJ, Slingerland RJ. Association of 1,5-anhydroglucitol and 2- h postprandial blood glucose in type 2 diabetic patients: response to Stettler et al. [letter]. Diabetes Care 2008;31(11):e89;author reply e90. Erratum in: Diabetes Care 2009;32(1): Van Vliet M, Von Rosenstiel IA, Schindhelm RK, Brandjes DP, Beijnen JH, Diamant M. Ethnic differences in cardiometabolic risk profile in an overweight/obese paediatric cohort in the Netherlands: a cross-sectional study. Cardiovasc Diabetol 2009, 8: Schindhelm RK, Jansen I, Beukhof JR, Coenen JL, Kuiper-Kramer PA. Therapeutische aferese: toepassing bij malaria en sikkelcelziekte [in Dutch, non-peer reviewed]. Analyse 2009;64(1): Alssema M, Schindhelm RK, Rijkelijkhuizen JM, Kostense PJ, Teerlink T, Nijpels G, Heine RJ, Dekker JM. Meal-composition affects insulin secretion in women with type 2 diabetes: a comparison with healthy controls. The Hoorn prandial study. Eur J Clin Nutr 2009;63(3): Van Vliet M, Von Rosenstiel IA, Schindhelm RK, Brandjes DP, Beijnen JH, Diamant M. The association of alanine elevated aminotransferase with the metabolic syndrome in an overweight and obese pediatric population of multiethnic origin. Eur J Pediatr 2009;168(5): Schindhelm RK, Diamant M, Bilo HJ, Slingerland RJ. 1,5-anhydroglucitol (1,5-AG) en glykemische instelling [review, in Dutch]. Ned Tijdschr Diabetologie 2009;7(2): Schindhelm RK, Van der Zwan LP, Teerlink T, Scheffer PG. Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification [review]? Clin Chem 2009;55(8): [IF: 6.263/2009] 2

3 25. Scheffer PG, Van der Zwan LP, Schindhelm RK, Vermue HP, Teerlink T. Myeloperoxidase concentrations in EDTA-plasma of healthy subjects are discordant with concentrations in heparin-plasma and serum [short communication]. Clin Biochem 2009;42(13-14): Van Vliet M, Von Rosenstiel IA, Schindhelm RK, Brandjes DP, Beijnen JH, Diamant M. Identifying the metabolic syndrome in obese children and adolescents: do age and definition matter? Curr Clin Pharmacol 2009;4(3): Schindhelm RK. Serum alanine aminotransferase, metabolic syndrome, and cardiovascular disease in an Australian population [letter]. Am J Gastroenterol 2009;104(11): Schindhelm RK, Van de Leur JJ, Rondeel JM. Salivary cortisol as an alternative for serum cortisol in the low-dose adrenocorticotropic hormone stimulation test? J Endocrinol Invest 2010;33(2); Schindhelm RK, Van Marwijk Kooy M, Coenen JL, Huijgens PC, Kuiper-Kramer PA. Monoklonale B-cellymfocytose: fysiologische bevinding of voorstadium van chronische lymfatische leukemie? [Monoclonal B-cell lymphocytosis: physiological entity or preliminary stage of chronic lymphocytic leukaemia?] Ned Tijdschr Geneesk 2010;154(19):A Van der Zijl NJ, Hanemaaijer R, Tushuizen ME, Schindhelm RK, Boerop J, Rustemeijer C, Bilo HJ, Verheijen JH, Diamant M. Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: a marker of incipient diabetic nephropathy? Clin Biochem 2010;43(7-8): Schindhelm RK, Lenters-Westra E, Fokkert MJ, Slingerland RJ. Glucose and glycated haemoglobin point-of-care testing and early diagnosis of diabetes and pre-diabetes. European Endocrinology 2010;6(1): Alssema M, El-Harchaoui K, Schindhelm RK, Diamant M, Nijpels G, Kostense PJ, Teerlink T, Heine RJ, Dallinga-Thie GM, Kuivenhoven JA, Dekker JM, Scheffer PG. Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease in HDL-cholesterol concentration following fat-rich meals: The Hoorn prandial study. Metabolism 2010;59(6): Van Vliet M*, Van der Heyden JC*, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze HJ. Overweight is highly prevalent in children with type 1 diabetes and associates with cardiometabolic risk. J Pediatr 2010;156(6): Rondeel JM, Albers JS, Schroor EJ, Schindhelm RK. Does sampling site influence levels of free thyroxine and thyrotropin determined by a current immunoassay [short communication]? Clin Biochem 2010;43(9): Schindhelm RK, Lenters-Westra E, Slingerland RJ. Glycated haemoglobin A1c (HbA1c) in the diagnosis of diabetes mellitus: don t forget the performance of the HbA1c assay [letter]. Diabet Med 2010;27(10); Schindhelm RK, Kuiper-Kramer PA, Van de Leur JJCM. Gezien: witte urine [in Dutch]. Medisch Contact 2010 (published online at Van der Zijl NJ*, Muskiet MH*, Tushuizen ME, Rijzewijk LJ, Schindhelm RK, Moors CC, Goossens GH, Blaak EE, Pouwels PJ, Diamant M. C-reactive protein mediates the association of liver fat and carotid intima media thickness in men with the metabolic syndrome and/or uncomplicated type 2 diabetes. Diab Met Syndr Clin Res Rev 2010;4(3): Lenters-Westra E, Weykamp C, Schindhelm RK, Siebelder C, Bilo HJ, Slingerland RJ. One in five laboratories using various HbA1c methods does not meet the criteria for optimal diabetes care management. Diabetes Technol Ther 2011;13(4):

4 39. Schindhelm RK & Van der Zwan LP. Myeloperoxidase as a diagnostic and prognostic marker in cardiology: beware of pre-analytical factors that may influence results [letter]. Int J Lab Hematol 2011;33(3): Schindhelm RK, Slingerland RJ, Slingschröder M, Dikkeschei LD, Hospers HJ. De psychologie van menselijke fouten in diagnostische laboratoria [in Dutch, review]. Ned Tijdschr Klin Chem Labgeneesk 2011;36(3): Schindhelm RK, Slingerland RJ, Slingschröder M, Dikkeschei LD, Hospers HJ. De psychologie van menselijke fouten in diagnostische laboratoria [in Dutch]. Tijdschrift van de Belgische Vereniging van Laboratorium Technologen 2011;38(6): Schindhelm RK. Letter by Schindhelm regarding article "high levels of systemic myeloperoxidase are associated with coronary plaque erosion in patients with acute coronary syndromes: a clinicopathological study" [letter]. Circulation 2011;e Scheffer PG, Tushuizen ME, Vermue HP, Schindhelm RK, Rustemeijer C, Diamant M. Effect of three consecutive meals on the physicochemical properties of HDL and LDL in individuals with the metabolic syndrome and patients with type 2 diabetes. Eur J Clin Nutr 2011;65(11): van Vliet M, van der Heyden JC, Diamant M, von Rosenstiel IA, Schindhelm RK, Heymans MW, Brandjes DP, Beijnen JH, Aanstoot HJ, Veeze HJ. Overweight children with type 1 diabetes have a more favourable lipid profile than overweight non-diabetic children. Eur J Pediatr 2012;171(3): Westers TM, van der Velden VH, Alhan C, Bekkema R, Bijkerk A, Brooimans RA, Cali C, Dräger AM, de Haas V, Homburg C, de Jong A, Kuiper-Kramer PE, Leenders M, Lommerse I, Te Marvelde JG, van der Molen-Sinke JK, Moshaver B, Mulder AB, Preijers FW, Schindhelm RK, van der Sluijs A, van Wering ER, Westra AH, van de Loosdrecht AA; on behalf of the Working Party on Flow Cytometry in MDS of the Dutch Society of Cytometry (NVC). Implementation of flow cytometry in the diagnostic work-up of myelodysplastic syndromes in a multicenter approach: Report from the Dutch Working Party on Flow Cytometry in MDS. Leuk Res 2012;36(4): Schindhelm RK, Wondergem MJ, Ten Boekel E, Admiraal J, Nap G, Hani L. A patient with a prolonged activated partial thromboplastin time and a deep intracerebral haemorrhage. Case Rep Neurol 2012;4(2): Schindhelm RK, Schoorl M, Van Pelt J. Comment on: Hardikar et al. Spuriously high prevalence of prediabetes diagnosed by HbA1c in young Indians partly explained by hematological factors and iron deficiency anemia. Diabetes Care 2012;35: [letter]. Diabetes Care 2013;36(2);e Schindhelm RK, Ten Boekel E, Heima NE, Van Schoor NM, Simsek S. Thyroid hormones and erythrocyte indices in a euthyroid population-based sample of older subjects. Eur J Int Med 2013;24(3); [IF: 2.049/2012] 48. Lenters-Westra E, Schindhelm RK, Bilo HJ, Slingerland RJ. Hemoglobin A1c: historical overview and current concepts [review]. Diabetes Res Clin Pract 2013;99(2): [IF: 2.741/2012]. 49. Scheffer PG, Schindhelm RK, Van Verschuer VM, Groenemeijer M, Simsek S, Smulders YM, Nanayakkara PW. No effect of atorvastatin and simvastatin on oxidative stress in patients at high risk for cardiovascular disease. Neth J Med 2013;71(7):24-30.[IF: 2.383/2012]. 4

5 50. Schindhelm RK, Ten Boekel E, Heima NE, Van Schoor NM, Simsek S. Thyroid hormones and erythropoiesis: a complex relation [response to letter-to-the-editor]? Eur J Int Med 2014;25(1):e6. [IF: 2.049/2012]. 51. Schindhelm RK, Berends JC, Wondergem MJ. Een benauwde vrouw met vlinderkernen in het bloed [in Dutch]. Ned Tijdschr Geneeskd 2014;158(6):A Lenters-Westra E, Schindhelm RK, Bilo HJ, Slingerland RJ. Differences in interpretation of haemoglobin A1c values among diabetes care professionals. Neth J Med 2014;72(9): Lenters-Westra E, Røraase T, Schindhelm RK, Slingerland RJ, Sandberg S. Biological variation of hemoglobin A1c: consequences for diagnosing diabetes mellitus [letter-to-theeditor]. Clin Chem 2014;60(12); Ten Boekel E, Schindhelm RK, Van Veen P, Oomes J, Simsek S. Lack of association between glucocorticoid receptor polymorphisms and erythropoiesis [letter-to-theeditor]. Int J Lab Hematol 2014;36(6):e Van der Spek AC, Schindhelm RK, Slieker WAT, Van Santen MM, Breeuwsma NG. De kunst van het kijken [in Dutch]. Ned Tijdschr Hematologie 2015;12(1): Schindhelm RK. The positive association of mean platelet volume with glycated hemoglobin A1c: clinically relevant? [letter-to-the-editor]. Prim Care Diabetes 2015; 9(4): Schindhelm RK, Renckens R, Duzenli S. De kunst van het kijken [in Dutch]. Ned Tijdschr Hematologie (accepted). BOOKS AND BOOK CHAPTERS 1. Schindhelm RK & Janssens PMW (2012). Risk management: choosing optimal tools on the basis of psychological analysis. In Z Zhang (Ed.), Risk assessment and management (pp ). Cheyenne: AcademyPublish.org (Publishing Services LLC). 2. Kramer PA & Schindhelm RK (2014). Diagnostiek in de acute leukemieën. Den Haag: Academic Pharmaceutical Productions bv. 3. Kramer PA & Schindhelm RK (2014). Diagnostiek in de chronische myeloproliferatieve aandoeningen en myelodysplastische syndromen. Den Haag: Academic Pharmaceutical Productions bv. ABSTRACTS AND CONFERENCE PROCEEDINGS (PRESENTING AUTHOR) 1. Schindhelm RK, Diamant M, Bakker SJ, Van Dijk RA, Scheffer PG, Teerlink T, Kostense PJ, Heine RJ. Elevated liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridemic subjects with type 2 diabetes mellitus. Paper presented at the 30 th Scientific Meeting of the Dutch Association for Diabetes Research (NVDO), November 18 th - 19 th 2004, Oosterbeek, the 2. Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ, Diamant M. Alanine aminotransferase is a predictor of coronary heart disease events: the Hoorn Study. Diabetologia 2005;48(Suppl1):A83-A83. Paper presented at the 41 st Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 10 th - 15 th 2005, Athens, Greece. 5

6 3. Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ, Diamant M. Alanine aminotransferase is a predictor of coronary heart disease events: a ten year follow-up of the Hoorn Study. Oral presentation at the Annual Scientific Meeting of the Netherlands Diabetes Epidemiology Study Group (NDESG), December 1 st 2 nd 2005, Doorwerth, the 4. Schindhelm RK, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ, Diamant M. Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study. Oral presentation at the Annual Scientific Meeting of the Netherlands Diabetes Epidemiology Study Group (NDESG), November 2 nd 3 rd 2006, Doorwerth, the 5. Schindhelm RK, Hospers HJ, Slingschröder M, Slingerland RJ. Van fout naar oplossing: een analyse van de klachten en fouten van 2009 van het Klinisch Chemisch Laboratorium. Oral presentation at the 10 th Isala Annual Science Meeting, October 21 st 2010, Zwolle, the 6. Schindhelm RK, Alssema M, Heine RJ, Barto R, Nijpels G, Dekker JM, Diamant M, Teerlink T, Schalkwijk CG. Carbohydrate, but not fat-rich meals cause a rise in plasma 3-deoxyglucosone concentration in females with type 2 diabetes mellitus. Diabetes 2005;54(Suppl1):A163-A163, poster (P-661) presented at the 65th Scientific Sessions of the American Diabetes Association (ADA), June 10 th -14 th 2005, San Diego, United States of America. 7. Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ, Diamant M. Alanine aminotransferase predicts coronary heart disease events: a ten year follow-up of the Hoorn Study. Poster presented (P158) at the 5th Scientific Meeting of the Netherlands Heart Association (NHS), October 11 th 2005, Amsterdam, the 8. Heine RJ, Schindhelm RK, Diamant M. Long-term pioglitazone treatment improves markers of liver function: results from PROactive. Diabetes 2006;55(Suppl1):A115-A116. Poster (P-484) presented at the 66th Scientific Sessions of the American Diabetes Association (ADA), June 9 th -13 th 2006, Washington DC, United States of America. 9. Schindhelm RK, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ, Diamant M. Alanine aminotransferase is associated with future risk of the metabolic syndrome in caucasian men and women: the Hoorn Study. Diabetes 2006;55(Suppl1):A225-A225. Poster (P-962) presented at the 66th Scientific Sessions of the American Diabetes Association (ADA), June 9 th -13 th 2006, Washington DC, United States of America. 10. Schindhelm RK, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ, Diamant M. Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study. Diabetologia 2006;49(Suppl1):A232-A233. Poster (P-376) presented at the 42nd Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 14 th -17 th 2006, Copenhagen, Denmark. 11. Schindhelm RK, Franken AA, Groeneveld PH, Rondeel JM. The low-dose adrenocorticotropic hormone stimulation test for the diagnosis of adrenal dysfunction: analysis of 220 consecutive tests performed over a period of 3 years. Ned Tijdschr Klin Chem Labgeneesk 2008;33(2): Poster (P-61) presented at the 61st Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 24 th 25 th 2008, Lunteren, the 12. Schindhelm RK, Slingerland RJ, Huisman AW, Rondeel JM. Vaststellen van referentiewaarden van vrij thyroxine met behulp van het laboratorium-informatiesysteem en het effect op de diagnostiek van schildklierfunctiestoornissen [in Dutch]. Poster presented at the Annual Science Meeting of the Isala Clinics, October 16 th 2008, Zwolle, the 13. Schindhelm RK, Kuiper-Kramer PA, Van Eyck J. Controle van cocaïnegebruik in urine bij een zwangere: denk ook aan de zwangerschapstest! [in Dutch]. Poster presented at the Annual Science Meeting of the Isala Clinics, October 16 th 2008, Zwolle, the Netherlands 6

7 14. Schindhelm RK, Slingerland RJ, Huisman AW, Rondeel JM. Vaststellen van referentiewaarden van vrij thyroxine met behulp van het laboratorium-informatiesysteem en het effect op de diagnostiek van schildklierfunctiestoornissen [in Dutch]. Ned Tijdschr Klin Chem Labgeneesk 2009;34(2): Poster (P-71) presented at the 62nd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 16 th 17 th 2009, Velhdoven, the 15. Schindhelm RK & Rondeel JM. Salivary cortisol as an alternative for serum cortisol in the lowdose adrenocorticotropic hormone stimulation test in the diagnosis of adrenal insufficiency? Ned Tijdschr Klin Chem Labgeneesk 2009;34(2): Poster (P-77) presented at the 62nd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 16 th 17 th 2009, Velhdoven, the 16. Van der Molen-Sinke JK, Abbes AP, Schindhelm RK, Kuiper-Kramer PA. To fish or not to fish : twee methoden voor het opwerken van beenmergaspiraat voor flowcytometrische beenmergdiagnostiek [in Dutch]. Ned Tijdschr Klin Chem Labgeneesk 2009;34(2): Poster (P-16) presented at the 62nd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 16 th 17 th 2009, Velhdoven, the 17. Schindhelm RK, Van der Molen-Sinke JK, Abbes AP, Kuiper-Kramer PA. De relatie tussen volume en zuiverheid van beenmergaspiraten die opgewerkt worden ten behoeve van celtypering binnen de hemato-oncologische laboratoriumdiagnostiek: analyse van 233 beenmergaspiraten [in Dutch]. Poster presentation (P15) at the Annual Science Meeting of the Isala Clinics, October 29 th 2009, Zwolle, the 18. Schindhelm RK, Van der Molen-Sinke JK, Grotjohan H, Abbes AP, Kuiper-Kramer PA. To cycle or not to cycle : effect van transport per fietskoerier op T-cel-activatie-markers in broncho-alveolaire lavage (BAL) bij niet-rokende patiënten zonder ernstige co-morbiditeit: de eerste resultaten van de Cycle Courier Activation-(CCA)-pilotstudie [in Dutch]. Poster presentation (P16) at the Annual Science Meeting of the Isala Clinics, October 29 th 2009, Zwolle, the 19. Schindhelm RK, Coenen JL, Van Marwijk Kooy M, Rondeel JM, Van de Leur JJ, Kuiper- Kramer PA. Vijftien jaar autologe stamcel transplantaties in de Isala klinieken: resultaten van de stamcelafereses [in Dutch]. Poster presentation (P17) at the Annual Science Meeting of the Isala Clinics, October 29 th 2009, Zwolle, the 20. Schindhelm RK, Van der Molen-Sinke JK, Abbes AP, Kuiper-Kramer PA. Effect of collection volume on the purity of bone marrow aspirates: analysis of 223 consecutive patient samples. Poster presentation (P14) at the BVAC/ABCA NVC meeting, November 12 th - 13 th 2009, Antwerp, Belgium. 21. Schindhelm RK, Van der Molen-Sinke JK, Grotjojan H, Abbes AP, Kuiper-Kramer PA. To cycle or not to cycle : the effect of cycle courier transportation on T-cell activation markers in bronchoalveolar lavages (BAL) in non-smoking patients without co-morbidity: results from the cycle courier transportation-(cct)-pilot study. Poster presentation (P16) at the BVAC/ABCA NVC meeting, November 12 th - 13 th 2009, Antwerp, Belgium. 22. Schindhelm RK, Van Marwijk Kooy M, Coenen JL, Huijgens PC, Kuiper-Kramer PA. Een toevallige lymfocytose? Denk ook aan de monoklonale B-cel lymfocytose [in Dutch]. Poster presentation at the 63 rd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 22 nd 23 rd 2010, Veldhoven, the 23. Schindhelm RK, Van der Molen-Sinke JK, Abbes AP, Kuiper-Karmer PA. De invloed van bloedbijmenging op de zuiverheid van beenmergaspiraten: een onmisbare kwaliteitsparameter [in Dutch]? Presentation at the 63 rd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 22 nd 23 rd 2010, Veldhoven, the 7

8 24. Schindhelm RK, Jobse PA, Krabbe JG, Van Marwijk Kooy M, Coenen JL. Huijgens PC, Kuiper-Kramer PA. Vijftien jaar autologe stamcel transplantaties in de Isala klinieken [in Dutch]. Poster presentation at the 63 rd Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 22 nd 23 rd 2010, Veldhoven, the 25. Schindhelm RK, Brouwers-van den Broeke N, Goudriaan-Barendrecht J. Bartels PCM. Operatie Stabiel : verbetering van het therapeutisch resultaat van een Trombosedienst. Ned Tijdschr Klin Chem Labgeneeskunde 2011;36(2): Poster (P63) presentation at the 64 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 14 th 15 th 2011, Veldhoven, the 26. Schindhelm RK, Hospers HJ, Slingschroder M. Slingerland RJ. Van fout naar oplossing: cognitive psychology meets clinical chemistry. Ned Tijdschr Klin Chem Labgeneeskunde 2011;36(2): Poster (P69) presentation at the 64 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 14 th 15 th 2011, Veldhoven, the 27. Schoorl M, Ruineveld IJ, Van Pelt J, Schindhelm RK. Evaluation of the erythrocyte deformability test on the LoRRca MaxSIS. Poster (P14) presented at the 19 th Bi-annual Meeting of the European Red Cell Society (ERSC), October 10 th 13 th 2013, Forteiland, IJmuijden, the 28. Schoorl M, Ruineveld IJ, Van Pelt J, Schindhelm RK. Evaluation of the erythrocyte aggregation test on the LoRRca MaxSIS. Poster (P15) presented at the 19 th Bi-annual Meeting of the European Red Cell Society (ERSC), October 10 th 13 th 2013, Forteiland, IJmuijden, the 29. Schindhelm RK, Reyneveld IJ, Van Pelt J, M. Schoorl. Analytical validation of the red blood cell aggregation test and the erythrocyte deformability test on the LoRRca MaxSIS. Poster (P-10) presented at the 67 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 10 th 11 th 20145, Velhdoven, the ABSTRACTS AND CONFERENCE PROCEEDINGS (CO-AUTHOR) 30. Diamant M, Schindhelm RK, Heine RJ. Long-term treatment with pioglitazone improves markers of liver function in patients with type 2 diabetes: results from PROactive. Diabetologia 2006;49(Suppl1):A72-A73. Oral presentation (OP-0113) at the 42nd Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 14 th -17 th 2006, Copenhagen, Denmark. 31. Alssema M, Schindhelm RK, Dekker JM, Diamant M, Nijpels G, Teerlink T, Scheffer PG, Kostense PJ, Heine RJ. Postprandial glucose, and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn Prandial Study. Oral presentation at the Annual Scientific Meeting of the Netherlands Diabetes Epidemiology Study Group (NSDEG), November 2 nd 3 rd 2006, Doorwerth, the 32. Van der Zijl NJ, Hanemaaijer R, Tushuizen ME, Schindhelm RK, Boerop J, Van Lent N, Rustemeijer C, Bilo H, Verheijen JH, Diamant M. Urine matrix metalloproteinase-2, -8 and -9 activities in type 2 diabetic nephropathy. Oral presentation at the Scientific Meeting of the Dutch Association for Diabetes Research (NVDO), November 28 th -29 th 2007, Doorwerth, the 8

9 33. Von Rosenstiel IA, Van Vliet M, Schindhelm RK, Brandjes DP, Beijnen JH, Diamant M. Ethnic differences in cardiovascular risk profile in an overweight/obese multiethnic paediatric cohort. Oral presentation at the 44th Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 7th-11th 2008, Rome, Italy. 34. Van Vliet M*, Van der Heyden JC*, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze HJ. Overweight is highly prevalent in children with type 1 diabetes and associates with hypertension, the metabolic syndrome and high alanine aminotransferase. Oral presentation at the 2009 Annual Meeting for Diabetes Research (NVDO), November 26 th 27 th 2009, Oosterbeek, the 35. Van der Zijl NJ*, Muskiet MH*, Tushuizen ME, Rijzewijk LJ, Schindhelm RK, Moors CC, Goossens GH, Blaak EE, Pouwels PJ, Diamant M. Association of liver fat and carotid intima media thickness is mediated by C-reactive protein in men with the metabolic syndrome and/or uncomplicated type 2 diabetes. Oral presentation at the 2009 Annual Meeting for Diabetes Research (NVDO), November 26 th 27 th 2009, Oosterbeek, the 36. Jobse PA, Schindhelm RK, Krabbe JG, Van Marwijk Kooy M, Coenen JL, Huijgens PC, Kuiper-Kramer PA. 15 years autologous stem cell transplantations in the Isala klinieken: evaluation of the results. Oral presentation at the 4 th Dutch Hematology Congress (DHC), January 27 th -29 th 2010, Papendal, the 37. Alssema M, Schindhelm RK, Dekker JM, Diamant M, Kostense PJ, Teerlink T, Scheffer PG, Nijpels G, Heine RJ. High postprandial glucose is associated with carotid intima media thickness but high postprandial triglycerides are not. Poster presentation at the scientific meeting of the Dutch Atherosclerosis Society (DAS), March 23 rd -24 th 2006, Ermelo, the 38. Alssema M, Schindhelm RK, Dekker JM, Diamant M, Nijpels G, Teerlink T, Scheffer PG, Kostense PJ, Heine RJ. Postprandial glucose, and not triglyceride concentrations are associated with carotid intima media thickness in women with normal glucose metabolism: the Hoorn Prandial Study. Diabetologia 2005;48(Suppl1):A727-A728. Poster presented (P-1205) at the 42 nd Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 14 th -17 th 2006, Copenhagen, Denmark. 39. Scheffer PG, Schindhelm RK, Alssema M, Diamant M, Teerlink T, Dekker JM, Kok A, Kostense PJ, Nijpels G, Heine RJ. Postprandial effect of two consecutive fat-rich and carbohydrate-rich meals on plasma myeloperoxidase in women with and without type 2 diabetes mellitus. Poster presented at the 17 th IFCC - FESCC European Congress of Clinical Chemistry and Laboratory Medicine, June 3 rd -7 th 2007, Amsterdam, the 40. Tushuizen ME, Bunck MC, Pouwels PJ, Bontemps S, Van Waesberghe JH, Schindhelm RK, Mari A, Heine RJ, Diamant M. Pancreatic fat content and beta-cell function in type 2 diabetic and non-diabetic males. Poster presentation at the 67th Scientific Sessions of the American Diabetes Association (ADA), June 22 nd -26 th 2007, Chicago, IL, United States of America. 41. Van der Molen-Sinke J, Bruggink G, Schindhelm R, Abbes A, Brandon Bravo Bruinsma G, Van Marwijk Kooy R, Kuiper-Kramer E. Wie krijgt een leukemie? : klinische celanalyse bij cytopenie [in Dutch]. Poster presented at the Annual Science Meeting of the Isala Clinics, October 23 rd 2007, Zwolle, the 42. Van der Zijl NJ, Hanemaaijer R, Tushuizen ME, Schindhelm RK, Boerop J, Rustemeijer C, Bilo HJ, Verheijen JH, Diamant M. Urine matrix metalloproteinase-2, -8 and -9 activities in type 2 diabetic nephropathy. Poster presented at the the 44 th Scientific Meeting of the European Associations for the Study of Diabetes (EASD), September 7 th -11 th 2008, Rome, Italy. 43. Van der Heyden J*, Van Vliet M*, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze, H. Cardiometabolic risk profile in children and adolescents with type 1 diabetes mellitus. Poster presented at the 69 th Scientific Sessions of the American Diabetes Association (ADA), June 5 th 9 th 2009, New Orleans, Louisiana, United States of America. 9

10 44. Van Vliet M*, Van der Heyden J*, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze, H. Cardiometabolic risk profile in children and adolescents with type 1 diabetes mellitus. Poster presented at the 45 th Annual Meeting of the European Association for the Study of Diabetes (EASD), September 29 th October 2 nd 2009, Vienna, Austria. 45. Krabbe JG, Schindhelm RK, Coenen JL, Van Marwijk Kooy M, Rondeel JM, Van de Leur JC, Kuiper-Kramer PA. Vijftien jaar autologe stamcel transplantaties in de Isala klinieken: resultaten van de klinische hersteldata [in Dutch]. Poster presentation (P44) at the Annual Science Meeting of the Isala Clinics, October 29 th 2009, Zwolle, the 46. Lenters-Westra E, Weykamp C, Schindhelm RK, Siebelder C, Bilo HJ, Slingerland RJ. One in five laboratories using various HbA1c methods does not meet the criteria for optimal diabetes care management. Ned Tijdschr Klin Chem Labgeneeskunde 2011;36(2): Poster (P69) presentation at the 64 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 14 th 15 th 2011, Veldhoven, the 47. Kok MB, Schindhelm RK, Slieker WAT. Malaise en donkerbruine urine: denk ook aan een uitgestelde transfusiereactie. Ned Tijdschr Klin Chem Labgeneeskunde 2011;36(2): Poster (P87) presentation at the 64 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 14 th 15 th 2011, Veldhoven, the 48. Lenters-Westra E, Schindhelm RK, Slingerland RJ, Bilo HJG. Interpretation of hemoglobin A1c values among different health care professionals. Annual Meeting of the AACC, July 15 th 19 th 2012, Los Angeles, USA. [NACB Distinguished Abstract Award 2012]. 49. Lenters-Westra E, Røraase T, Schindhelm RK, Slingerland RJ, Sandberg S. Biological variation of hemoglobin A1c: consequences for diagnosing diabetes mellitus. Ned Tijdschr Klin Chem Labgeneeskunde 2015;40(2): Poster (P59) presentation at the 68 th Annual Scientific Meeting of the Netherlands Society for Clinical Chemistry and Laboratory Medicine (NVKC), April 16 th 17 th 2015, Veldhoven, the 10