IRCCS FONDAZIONE STELLA MARIS La Risonanza Magnetica a 7 Tesla della Fondazione Stella Maris: stato dell arte

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1 IRCCS FONDAZIONE STELLA MARIS La Risonanza Magnetica a 7 Tesla della Fondazione Stella Maris: stato dell arte IMAGO7 project 21 km PISA 7T magnet Stella Maris M. Tosetti, - People LAB RM Stella Maris Stella Maris e Risonanza Magnetica: da 0 a 7 Tesla in 100 metri! (MDS) 0T Massimo Del Sarto Engineer Laura Biagi Danilo Scelfo Alessandra Retico -INFN Lucia Billeci Engineer 1.5T 7T Andrea Guzzetta Roberta Battini Chiara Pecini Neuropsychologist Giovanni Cioni David Burr Visual Scientist Anna Maria Valleriani Neuroradiologist Concetta Morrone Visual Scientist Mirko Cosottini Neuroradiologist Sofia Crespi Psychologist Sara Calderoni

2 THE IMAGO7 RESEARCH FOUNDATION The IMAGO7 Foundation The IMAGO7 Foundation is devoted to develop research in the field of UHF MR imaging and all related disciplines studying in vivo and in vitro molecular phenomena, with new technologies. The Foundation is a consortium collected around the facilities provided by a high field 7T scanner. The budget of the 7T SCANNER has been financed (50% from the Foundation CaRiPi and the other 50% from the single partners of the Foundation). The Stella Maris Scientific Institute, Pisa IRCCS (Istituto di Ricerca e Cura a Carattere Scientifico in Developmental Neurology, Psychiatry and Rehabilitation, The University of Pisa Department of Chemistry The Pisa University General Hospital Department of Radiology Department of Neuroscience The MEDEA Scientific Institute, Bosisio Parini (Lecco) IRCCS (Istituto di Ricerca e Cura a Carattere Scientifico in Developmental Neurology, Psychiatry and Rehabilitation The CARIPI Foundation (Pisa) and IMAGO7 today Structure Admin President Dr. Roberto Cutajar Board of directors (representatives of the Partners, Dr. Roberto Cutajar, Prof. Roberto Barsotti, Dr. Carlo Tomassini, Dr. Laura Nulli) Revisori dei Conti: Dr. Riccardo Grasso, Rag. Daniele Cavadini, Dr. Luigi Nannipieri. Scientific Committee (representatives of the Partners and other experts) Stella Maris Scientific Institute -Prof Renzo Guerrini Scientific Director -Prof Giovanni Cioni Clinical Director -Dr MR Laboratory MEDEA Scientific Institute -Dr Paolo Brambilla -Department of Neuroscience -Ing Paola Grigioni - Laboratory of Bioengeneering University of Pisa and Pisa General Hospital -Prof Alberto Del Guerra, -Prof Carlo Veracini Department of Chemistry -Prof Pietro Pietrini Dep of Clinical Biochemis. and Molecular Biology - Prof. Carlo Bartolozzi Department of Radiological Sciences Experts: Ing. Prof. Giuliano Manara, Dept of Information Engeneering Dr. Mirco Cosottini, Fondazione Cassa di Risparmio di Pisa Dep. Neurosciences Prof Arnaldo Stefanini (President of CSI7) Dec 2010 the shielding July 2010 Aug 2010 Oct 2010

3 and the building around and his departure in the Italian press Delivery of the 7T magnet at the Imago7 Foundation June 9, 2011 Actual UHF-MR worldwide distribution th November systems >= 7T 3

4 The evolution of MR images 1980 Europe: 1. Institute for Neuro-Biology, Magdeburg, Germany (2005); 2. ELH for Magnetic Resonance Essen, Germany (2006); 3. Max Planck Institute, Tübingen, Germany (7 T e 9.4 T) (2007); 4. Max Planck Institute, Leipzig, Germany (2007) (9.4T); 5. CEA, Orsay, France (2007); 6. Medical University of Vienna, Vienna, Austria (2008); 7. University of Nottingham, UK (2005); 8. ETH Zurich, Switzerland (2006); 9. Center for Imaging in Biomedicine, Lausanne, Switzerland (2006); 10. University of Leiden, Netherlands (2007); 11. University of Utrecht, Netherlands (2007); 12. Research Center Jülich, Germany; 13. German Cancer Research Center (DKFZ), Heidelberg, Germany (2008); 14. Max-Delbrück Center, Berlin, Germany (2008). USA: 15. New York University, NYC, USA (2007); 16. Center for MR Research, Minneapolis, USA (2005); 17. UPMC, Pittsburgh, USA (2007); 18. Cleveland UHF Research Center USA (2006); 19. The Ohio State University, Columbus, USA (2006); 20. University of Texas SouthWest, Dallas TX USA (2006); 21. Vanderbilt University, Nashville, TN USA (2006); 22. KKI, Johns Hopkins, Baltimore, MD USA (2008); 23. NIH Bethesda, Maryland USA (2002); 24. University of California San Francisco CA USA (2004); 25. Stanford University, Stanford CA USA (2004); 26 Oregon Health & Science University (Portland, USA); 27. University of Illinois, Chiacago (9.4T) (2004); 28. Massachusetts General Hospital, MGH, Boston, USA (2005); 29. Hospital of the University of Pennsylvania (HUP), Philadelphia, USA (2008); 30. Auburn University, Alabama, USA (2010). ASIA: 31.Gachon Medical School, Incheon, Korea (2004); 32. Niigata University Brain Research Institute Japan (2003), 33. Advanced Medical Research Center Iwate Medical University Japan Zeugmatography 1974 end of 80s 1.5 T end of 90s now 3 T 7 T Milestones of Pisa 7T project Oct 2005 Oct 2005 Oct 2006 Oct 2006 Dec 2007 Dec 2007 Mar Mar Sep Sep presentation of of the the project project for for obtaining a grant grant by by the the Fondazione Cassa Cassa di di Risparmio (Pisa) (Pisa) first approval of the project first approval of the project to to run run the the project, project, the the Imago7, a Consortium among among 4 Institutions, is is created audits with the manufacturers audits with the manufacturers 2010 Apr 2011 Apr 2011 Milestones of 7T project Beginning of of preparation of of the site in in Pisa and of of the MR system c/o the manufacturer Physics Dep starts to operate Physics Dep starts to operate Magnet and Electronics shipping from New York April 30th Mar 2009 Mar 2009 order of the tomograph order of the tomograph June 2011 June 2011 Delivery on site June 9th Jun 2009 Jun 2009 processes of of authorization at at the the local local and and central central government for for the the permission procedures

5 Milestones of 7T project Oct2011 Magnet cool-down starts Magnet cool-down starts Nov2011 Installation complete Installation complete Dec 2011 Dec 2011 ramp-up and calibration ramp-up and calibration Jan 2012 Jan 2012 commissioning and start-up commissioning and start-up IMAGO7 Foundation Pisa