2015 Compound Libraries

Transcription

1 21 Compound Libraries

2 Compound Libraries (96-Well) Contents What is a Compound Library? Compound Libraries are ready-to-use chemical libraries used for drug discovery, lab drug screening, drug target identification, and other pharmaceutical-related applications. The libraries consist of a unique and diverse collection of over 2,1 small molecules with validated biological and pharmacological activities. L17 Bioactive Compound Library...1 L12 Kinase Inhibitor Library...2 L13 FDA-approved Drug Library...3 L11 Inhibitor Library... 4 L19 Epigenetics Compound Library... Safety and effectiveness of the compounds has been demonstrated by preclinical and clinical research, and many of the compounds are FDA-approved. L14 Natural Product Library... L3 Target Selective Inhibitor Library...6 The collections of unique small molecules, which include inhibitors, activators, antagonists, and agonists, are focused on over 2 targets that are part of more than 2 signaling pathways. These pathways include, among many others, apoptosis, /Akt/, and MAPK pathways. L22 GPCR Compound Library...7 L3 Anti-cancer Compound Library...8 L18 Tyrosine Kinase Inhibitor Library...9 L21 Stem Cell Signaling Compound Library...9 L23 Cambridge Cancer Compound Library...1 L24 Pfizer Licensed Compound Library...11 L26 Compound Library L27 Ion Channel Ligand Library...12 Compound Library Advantages Structurally diverse, medicinally active, and cell permeable Rich documentation with structure, IC, and customer reviews NMR and HPLC validated to ensure high purity 4 4 You can customize your library by selecting compounds of interest. Build the right library for your research endeavors by choosing from compounds in all of our available libraries. 4 You could select: 4 L28 /Akt Inhibitor Library...13 L33 Apoptosis Compound Library...13 L34 MAPK Inhibitor Library...14 L2 Protease Inhibitor Library...14 L31 Anti-infection Compound Library...1 L29 Anti-diabetic Compound Library Specific Compounds Quantities Plate map Concentration Please contact us at info@selleckchem.com to customize your library. 1 1 Product Citations Nat Med, 214, 2(8): 94-6 Nat Cell Biol, 21, 17(1): 7-67 Nat Prod Rep, 214, 31(6): Cancer Res, 214, 74: 172 Oncogene, 214, 1.138/onc Oncotarget, 214, (1): Mol Cancer Ther, 214, 13(2): ACS Chem Biol, 214, 9(): Mol Cancer Res, 214, 12(): Antimicrob Agents Chemother, 214, 8(8): Format (Dry/solid or DMSO solution) 1

3 Bioactive Compound Library Cat.No. Kinase Inhibitor Library L17 Bioactive Compound Library Cat.No. A unique collection of 378 kinase inhibitors for high throughput screening (HTS) and Bioactivity and safety confirmed by preclinical research and clinical trials Some inhibitors have been approved by the FDA Most are ATP competitive Rich documentation with structure, IC, and customer reviews A unique collection of 192 bioactive chemical compounds for high throughput screening (HTS) and Bioactivity and safety confirmed by preclinical research and clinical trials Some compounds have been approved by the FDA Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents Rich documentation with structure, IC, and customer reviews 1 μl/well (1 mm solution) L12 Kinase Inhibitor Library 2 μl/well (1 mm solution) 1 μl/well (1 mm solution) 2 μl/well (1 mm solution) 3 Number of Kinase Inhibitors Re cep tor 2 es t og en 2 rog en /pr og Est Number of Bioactive Compounds 1 3 rs he Ot AM PA /ka ina te Re c ep tor 1 Phone: (832) info@selleckchem.com 2

4 FDA-approved Drug Library Inhibitor Library Cat.No. L13 FDA-approved Drug Library Cat.No. L11 Inhibitor Library A unique collection of 118 FDA approved drugs for high throughput screening (HTS) and Locate new targets for old drugs Bioactivity and safety confirmed by clinical trials All compounds have been approved by FDA Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc Number of FDA-approved Compounds AMPA/kainate Receptor A unique collection of 1224 small molecule inhibitors for high throughput screening (HTS) and Bioactivity and safety confirmed by preclinical research and clinical trials Some inhibitors have been approved by the FDA Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents AChR V RAAS MEK Raf GluR Akt p38 MAPK ATPase Bcl-2 IGF-1R ATM/ATR DPP-4 DUB HER2 IκB/IKK p3 PLK PPAR Rho CFTR Kinesin Syk Aromatase Caspase Chk GPR Integrase MMP NF-κB PKC STAT ALK BTK CETP Factor Xa IAP MAO Mdm2 PDK-1 TNF-alpha c-kit CRM1 DHFR FAAH JNK LRRK2 p97 camp CaSR Dynamin FXR IDO PAK PERK P-gp S6 Kinase TRPV APC BACE c-myc CSF-1R CXCR DNA-PK ERK gp12/cd4 Integrin NOD1 PAFR PKA Survivin Tie-2 VDA Wee1 -HT Receptor HSP (e.g. HSP9) Sodium Channel Calcium Channel P4 (e.g. CYP17) Androgen Receptor Wnt/beta-catenin Potassium Channel Dehydrogenase Opioid Receptor Cysteine Protease HIV Protease Transferase Carbonic Anhydrase GABA Receptor HCV Protease P2 Receptor Serine Protease Hydroxylase OX Receptor Proton Pump S1P Receptor Telomerase -alpha Reductase Ferroptosis Liver X Receptor LPA Receptor Adenosine Receptor Beta Amyloid E1 Activating E2 Conjugating E3 Ligase Ephrin receptor MT Receptor IL Receptor Phosphorylase Substance P Adrenergic Receptor Histamine Receptor Dopamine Receptor Reverse Transcriptase Histone Methyltransferase Microtubule Associated Cannabinoid Receptor DNA Methyltransferase HMG-CoA Reductase Histone Demethylase AMPA/kainate Receptor Phospholipase (e.g. PLA) Histone Acetyltransferase Procollagen C Proteinase Vasopressin Receptor 3 Phone: (832)

5 Epigenetics Compound Library / Natural Product Library Target Selective Inhibitor Library Cat.No. L19 Epigenetics Compound Library Cat.No. L3 Target Selective Inhibitor Library A unique collection of 128 small molecule modulators (inhibitors and activators) with biological activity used for epigenetics research and associated assays. A variety of structurally and mechanistically different compounds are included A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications NMR and HPLC validated to ensure the highest purity MAO Histone Methyltransferase DNA Methyltransferase Histone Demethylase Histone Acetyltransferase Sodium Channel A unique collection of 464 validated bioactive compounds covering over 14 targets Each compound was selected based on its ability to principally interact with a single target, leading to minimal off-target activity Selectivity is at least 1-fold higher relative to non-primary target(s) Targets cover a wide variety of signaling pathways, including /Akt, MAPK, PTK,, apoptosis, and others This unique tool is ideal for studying mechanisms of action or for target screening Compounds are structurally diverse, biologically active, and cell permeable Selleck provides rich supporting documentation which includes compound structure, IC, and customer reviews Compounds are NMR and HPLC validated to ensure our customers receive high purity compounds ATM/ATR GluR Integrase LRRK2 JNK LPA Receptor PAK PKA DNA Methyltransferase RAAS Rho STAT NF-κB OX Receptor P2 Receptor Substance P Survivin GABA Receptor AChR V p3 PDK-1 Tie-2 HMG-CoA Reductase ALK p97 PERK VDA Opioid Receptor GPR P-gp Wee1 P4 (e.g. CYP17) Aromatase PKC Adrenergic Receptor Potassium Channel Cat.No. L14 Natural Product Library MEK PLK Caspase CETP CFTR PPAR Raf S1P Receptor S6 Kinase Transferase Histamine Receptor -HT Receptor Sodium Channel -alpha Reductase A unique collection of 131 natural products for high throughput screening (HTS) and Structurally diverse, bioactive, and cell permeable Rich documentation with structure and IC NMR and HPLC validated ensure high purity Akt ATPase Bcl-2 BTK Chk CRM1 DHFR DPP-4 FAAH Syk Telomerase TNF-alpha TRPV Beta Amyloid CSF-1R CXCR E1 Activating Cysteine Protease Dopamine Receptor HSP (e.g. HSP9) Cannabinoid Receptor Adenosine Receptor AMPA/kainate Receptor Histone Demethylase Liver X Receptor Microtubule Associated Reverse Transcriptase DUB Factor Xa camp CaSR E2 conjugating E3 Ligase Dehydrogenase Histone Acetyltransferase IκB/IKK Kinesin Dynamin Ferroptosis ERK gp12/cd4 Histone Methyltransferase Phospholipase (e.g. PLA) Phosphorylase MAO IDO Wnt/beta-catenin Serine Protease MMP IAP FXR MT Receptor Androgen Receptor Vasopressin Receptor p38 MAPK IGF-1R HER2 NOD1 Calcium Channel Integrase Hydroxylase PAFR Carbonic Anhydrase Phone: (832)

6 GPCR Compound Library Anti-cancer Compound Library Cat.No. L22 GPCR Compound Library Cat.No. L3 Anti-cancer Compound Library A unique collection of 24 small molecules targeting G protein coupled receptors used in GPCR screening by pharmaceutical and biotechnology companies in various research and drug development projects All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery. It is estimated about 2 so-called orphan GPCRs are functionally unknown, as a result, use of our GPCR Small Molecule Compound Library for screening the functionally unknown GPCRs may yield potentially new GPCR-based drug candidates NMR and HPLC validated to ensure the highest purity AChR GluR camp CaSR CXCR -HT Receptor GABA Receptor P2 Receptor OX Receptor S1P Receptor MT Receptor Opioid Receptor Adrenergic Receptor Histamine Receptor Dopamine Receptor Cannabinoid Receptor AMPA/kainate Receptor A unique collection of 386 anti-cancer small molecules for 12 types of cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc This library contains inhibitors of,,,,,, etc Some compounds have been approved by the FDA V MEK PLK Aromatase Bcl-2 Kinesin Raf Mdm2 p38 MAPK Akt c-kit IGF-1R PKC STAT TNF-alpha ATM/ATR Caspase Chk FXR HER2 IL Receptor IκB/IKK JNK PDK-1 Rho Telomerase APC BTK CETP DHFR DNA-PK DUB ERK FAAH Hydroxylase IAP IDO MMP p3 PAK PERK PPAR Substance P Survivin Syk Tie-2 Transferase VDA Wee1 Microtubule Associated HSP (e.g. HSP9) Androgen Receptor Wnt/beta-catenin DNA Methyltransferase S1P Receptor Dehydrogenase Histone Demethylase HMG-CoA Reductase Liver X Receptor 7 Phone: (832)

7 Tyrosine Kinase Inhibitor Library / Stem Cell Signaling Compound Library Cambridge Cancer Compound Library Cat.No. L18 Tyrosine Kinase Inhibitor Library Cat.No. L23 Cambridge Cancer Compound Library A unique collection of 141 tyrosine kinase inhibitors for high throughput screening (HTS) and Bioactivity and safety confirmed by preclinical research and clinical trials Some tyrosine kinase inhibitors have been approved by FDA Structurally diverse, medicinally active and cell permeable Rich documentation with structure, IC and customer reviews NMR and HPLC to ensure the high purity V IGF-1R HER2 Syk ALK BTK c-kit Cat.No. L21 CSF-1R Tie-2 VDA Ephrin receptor Stem Cell Signaling Compound Library A unique collection of 81 small molecule inhibitors with biological activity used for stem cell regulatory and signaling pathway research. All of the small molecule inhibitors in the stem cell screening library are well characterized with biological and pharmaceutical activity A powerful tool for researching the mechanism behind stem cells, regenerative therapy, means differentiation, drug screening based on tumor stem cells, as well as other pharmaceutical and biological applications The stem cell inhibitor library contains small molecules associated with signaling pathways which modulate the function of stem cells such as Wnt, Notch, SMAD, and Hedgehog signaling NMR and HPLC validated to ensure the highest purity A highly value-added library derived through a collaboration with researchers at the MIT Koch Institute A unique collection of 313 cancer-targeted compounds for high throughput screening (HTS) and Embraces the whole spectrum of cancer targets, from kinases to Notch signaling, to metabolic targets Structurally diverse, medicinally active and cell permeable Rich documentation with structure and IC NMR and HPLC to ensure the high purity V Raf Bcl-2 MEK Kinesin PLK Akt ATM/ATR Chk c-kit FXR IGF-1R IκB/IKK PKC APC BTK Caspase CETP DHFR DNA-PK FAAH Mdm2 NF-κB p3 PDK-1 PPAR Rho STAT Survivin Syk Tie-2 VDA Wee1 Aromatase p38 MAPK S1P Receptor Telomerase TNF-alpha IL Receptor S6 Kinase Substance P Transferase Microtubule Associated Androgen Receptor DNA Methyltransferase HSP (e.g. HSP9) Dehydrogenase Histone Methyltransferase HMG-CoA Reductase Liver X Receptor Wnt/beta-catenin Wnt/beta-catenin PKC BACE STAT 9 Phone: (832)

8 Pfizer Licensed Compound Library Compound Library / Ion Channel Ligand Library Cat.No. L24 Pfizer Licensed Compound Library Cat.No. L26 Compound Library All 8 compounds are licensed by Pfizer and have been marketed or clinically proven bioactive Wide range of potential uses: from anti-cancer compounds (Bosutinib) to a glycylcycline antiobiotic (Tigecycline) to combat the growing prevalence of antibiotic resistance Purchase as a diverse library or individually to meet your drug-discovery needs Reliability Guarantee: All compounds are developed, validated, and manufactured by Pfizer All compounds are validated using NMR and HPLC Detailed preclinical research data and safety information available A unique collection of 12 small molecules with autophagy-inducing or autophagy-inhibiting activity A useful tool for studying the roles of molecules in autophagy Targets,,,,, E3 Ligase, Calcium Channel,, etc V HER2 -HT Receptor Calcium Channel Phosphorylase IκB/IKK Calcium Channel Opioid Receptor Adrenergic Receptor Potassium Channel LRRK2 APC Microtubule Associated Potassium Channel MEK Aromatase Dopamine Receptor Procollagen C Proteinase Bcl-2 ATPase Mdm2 Adrenergic Receptor Serine Protease CETP camp Sodium Channel RAAS Factor Xa P4 (e.g. CYP17) DUB Proton Pump Dopamine Receptor AChR FAAH p38 MAPK Proton Pump Histamine Receptor E1 Activating Survivin S6 Kinase Sodium Channel HMG-CoA Reductase p3 p97 E3 Ligase TNF-alpha HSP (e.g. HSP9) IL Receptor HSP (e.g. HSP9) Cat.No. L27 Ion Channel Ligand Library A unique collection of 2 small molecule modulators used for Ion channel research Sodium Channel Calcium Channel Potassium Channel GABA Receptor Dopamine Receptor 11 Phone: (832)

9 /Akt Inhibitor Library / Apoptosis Compound Library MAPK Inhibitor Library / Protease Inhibitor Library Cat.No. L28 /Akt Inhibitor Library Cat.No. L34 MAPK Inhibitor Library A unique collection of 98 small molecule inhibitors used for /Akt/ pathway research A valuable tool for researching the survival, proliferation, and apoptosis of cells Akt ATM/ATR PDK-1 S6 Kinase DNA-PK PKA Other A unique collection of 44 small molecule inhibitors used for MAPK signaling research MEK Raf p38 MAPK JNK ERK Cat.No. L33 Apoptosis Compound Library A unique collection of 3 small molecules used for apoptosis research Bcl-2 p3 Caspase IAP Mdm2 TNF-alpha PERK Survivin Cat.No. L2 Protease Inhibitor Library A unique collection of 43 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and Bioactivity and safety confirmed by preclinical research and clinical trials DPP-4 HIV Protease HCV Protease Serine Protease Caspase Cysteine Protease MMP BACE 13 Phone: (832)

10 Anti-infection Compound Library / Anti-diabetic Compound Library Cat.No. L31 Anti-infection Compound Library A unique collection of 118 anti-infective small molecules with biological activity of antibiotics, antifungal drugs,anti-hiv,etc The compounds in this library mainly include sulfonamides, aminoglycosides, tetracyclines and macrolides A useful tool to research infectious disease for academic institutions, medical research organizations, and the pharmaceutical industry Integrase Reverse Transcriptase Cysteine Protease DHFR HIV Protease P4 (e.g. CYP17) NF-κB HCV Protease Serine Protease Cat.No. L29 Anti-diabetic Compound Library A unique collection of 32 small molecules affecting the development of diabetes DPP-4 GPR Calcium Channel Transferase PPAR Potassium Channel Dehydrogenase P4 (e.g. CYP17) 1

11 Order & Inquiry Toll Free: Tel: Fax: Delivery Tel: Order & Inquiry Tel: (Language: English, French, Spanish, German) Fax: Delivery Technical Support Tel: x3 (We strive to reply to all inquiries within one business day.) --- Inhibitor Expert (Inhibitors, Compound Libraries)