DANISH BIOTECH COMPANIES ULTIMO /2-2010

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1 DANISH BIOTECH COMPANIES YEAR OF ESTABLISHMENT TYPE OF ACTIVITY COMPANY FOCUS AREA CONTACT INFORMATION Acadia Pharmaceuticals A/S 1997 R&D ACE BioSciences A/S 2000 R&D Action Pharma A/S 2000 R&D Affitech A/S 1990 R&D AgroFerm A/S 2002 Drug discovery and clinical development of novel treatments for schizophrenia, Parkinson's disease, and other central nervous system disorders. Develops novel, protein-based vaccines and antibodies to address infectious diseases caused by pathogens such as bacteria, fungi and viruses. Develops new drugs and treatment concepts within cardiovascular diseases associated with ischemia and inflammation. Develops new immunotherapy drugs for the treatment of cancer and inflammatory diseases. Produces lysine to the feedstuff industry utilizing residues from the agro industry and agricultural plant products. Acadia Pharmaceuticals A/S Bredgade 38, DK-1260 Copenhagen Tel ACE BioSciences A/S Unsbjergvej 2A, DK-5220 Odense Tel Action Pharma A/S Science Park Aarhus, Brendstrupgaardsvej 102, DK-8200 Aarhus Tel Affitech A/S Dronninggårds Allé 136 DK-2840 Holte Tel AgroFerm A/S Limfjordsvej 4, DK-6715 Esbjerg Tel ALK-Abelló A/S 1960 Develops and produces products for diagnosis, prevention and treatment of allergies. ALK-Abelló A/S Boege Alle 6-8, DK-2970 Hoersholm Tel Alkalon ApS 2007 Development Develops, registers and commercializes new generic OTC-products for the pharmaceutical industry. Alkalon ApS Trojborggade 3A, DK-1757 Copenhagen Tel Antibody Project ApS 2006 R&D Focuses on supply of polyclonal antibodies. The Antibody Project ApS Kullingegade 31, DK-5700 Svendborg Tel

2 Aqualife A/S 2001 R&D Aquaporin A/S 2005 R&D Develops plant-based solutions and products, by combining molecular biology and plant physiology with disciplines like protein chemistry. Develops the Aquaporin membrane technology capable of separating and purifying water from all other compounds. Aqualife A/S Symbion Science Park, Tel Aquaporin A/S Diplomvej 337, DK-2800 Kgs. Lyngby Tel Aros Pharma ApS 2009 R&D Ascendis Pharma A/S 2007 R&D Atonomics A/S 2000 R&D Axellia Pharmaceuticals ApS 1959 Baxter A/S 1983 Focus on novel pharmaceuticals targeting unmet needs within pain relief, infectious disease, inflammation, respiratory diseases and immuno-suppressed patients Improves drugs by using a transient linker technology, TransientLink, which conjugates peptides, proteins and small molecules to a carrier molecule in a reversible fashion which allows an unmodified active drug to be released in the body in a precise fashion. Develops electro- and nanomechanical diagnostic for point of care technologies. Produces active pharmaceutical ingredients (APIs) as well as sterilized drugs. Produces pharmaceuticals and medico equipment used in the treatment of patients with immunodeficiency, infectious diseases, cancer, kidney diseases and trauma. Aros Pharma ApS Krogshoejvej 41, DK-2880 Bagsvaerd Tel: Ascendis Pharma A/S Tuborg Boulevard 12, DK-2900 Hellerup Tel Atonomics A/S Vestre Teglgade 10, DK-2450 Copenhagen Tel Axellia Pharmaceuticals ApS Dalslandsgade 11, P.O. Box 1736, DK-2300 Copenhagen Tel Baxter A/S Gydevang 43, DK-3450 Alleroed Tel Bavarian Nordic A/S 1994 Develops and produces innovative vaccines to prevent and treat infectious diseases: smallpox, HIV and cancer. Bavarian Nordic A/S Boegeskovvej 9, DK-3490 Kvistgaard Tel:

3 Besst-test ApS 2001 R&D Developing a diagnostic device for monitoring the blood coagulation mechanism by means of a urine sample. Besst-test ApS Diplomvej 381, DK-2800 Kgs. Lyngby Tel Bifodan A/S 1987 BioGasol ApS 2006 R&D Biogen Idec Manufacturing ApS 2001 BioLocus A/S 1999 R&D Biomonitor ApS 2003 service Bioneer A/S 2003 Service Develops and produces probiotic products and other preparations for human and veterinary use. Bifodan is specialised in handling lactic acid bacteria. Develops and designs technologies needed for second generation bioethanol production. BioGasol s process technology is innovative and offers a cost effective production of biofuels such as bioethanol, hydrogen, methane and other valuable byproducts. Research and development within oncology, neurology and immunology. Develops a technology that makes it possible to replace biocides in anti-fouling paints for boats, ships and offshore constructions with enzymes. Develops clinically useful methods to monitor therapies with cytokine-modulating biopharmaceuticals and to reveal and prevent immunogenic properties of biopharmaceuticals. Focuses on IP generation and licensing to generate revenues, but also maintains a high quality service offering to help with discovery and development of biotechnology products Bifodan A/S Bogbinderivej 6, DK-3390 Hundested Tel: BioGasol ApS Technical University of Denmark, Building 205 DK-2800 Kgs. Lyngby Tel: Biogen Idec Manufacturing ApS Biogen Idec Allé 1, DK-3400 Hilleroed Tel BioLocus A/S Agern Allé 3, DK-2970 Hoersholm Tel Biomonitor ApS Tel Bioneer A/S Kogle Allé 2, DK-2970 Hoersholm Tel BioPorto Diagnostics A/S 2000 Development, diagnostics Develops and markets antibodies and antibody-based products, including tests to diagnose human disease. The Company s developments include a test (NGAL) to diagnose and monitor acute kidney damage. BioPorto Diagnostics A/S Grusbakken 8, DK-2820 Gentofte Tel

4 BKG Pharma ApS 2004 R&D Develops novel therapies against human pathogenic multiresistant bacteria. BKG-Pharma ApS, Vintervej 2, DK-2920 Charlottenlund Tel BSP Pharma A/S 2001 R&D Focuses on relieving the symptoms of eczema, arthritis and muscle pain, psoriasis and herpes simplex based on natural products. BSP Pharma A/S M.P. Bruuns Gade 27, DK-8000 Aarhus Tel Carlsberg Research Center 1875 R&D Research on fermentation within the area of brewing. Carlsberg Research Center Gamle Carlsberg Vej 10, DK-2500 Valby Tel Center for Clinical and Basic Research A/S 1992 R&D Basic and applied research in biology related to diseases in the years after menopause, especially osteoporosis and other bonerelated diseases. CCBR A/S Ballerup Byvej 222, DK-2750 Ballerup Tel Chr. Hansen A/S 1874 CLC Bio A/S 2004 R&D CMC Biologics A/S 2001 service Colotech A/S 1999 R&D Develops natural ingredient solutions for the food, pharmaceutical, nutritional and agricultural industries. Develops bioinformatic software based on the latest scientific developments in bioinformatics. A Contract Manufacturing Organization offering manufacturing services using microbial fermentation and mammalian cell culture processes. Develops innovative drugs for the prevention and treatment of human cancers and its precursors. Chr. Hansen A/S Boege Alle 10-12, DK-2970 Hoersholm Tel CLC Bio A/S Science Park Aarhus, Gustav Wieds Vej 10, DK-8000 Aarhus Tel: CMC Biologics A/S Vandtaarnsvej 83B, DK-2860 Soeborg Tel Colotech A/S Copenhagen Science Park, Tel

5 Como Biotech ApS 2000 R&D Works with proteins for diagnostic/therapeutic purposes. Como Biotech ApS c/o Oestjysk Innovation A/S Gustav Wieds Vej 10, DK-8000 Aarhus Tel: Copenhagen Biotech Assets ApS 2002 R&D Discovery within the area of protein misfolding, novel Bovine Spongiforme Encephalopathies (BSE) diagnostic assays and novel drugs against BSE and Alzheimer s disease. Copenhagen Biotech Assets ApS Caroline Mathilde Vej 11, DK-2950 Vedbaek Tel Cym1P A/S 2003 R&D Enhanced production of recombinant peptides. Cym1P A/S Niels Jernes Vej 10, DK-9220 Aalborg Tel CytoGuide ApS 2007 R&D Cytotech ApS 1989 DanDrit Biotech A/S 2001 R&D Dako A/S 1966 Develops two-component drugs which target specific receptors on cells of the immune system, and by means of these receptors ensure efficient uptake of the drug where it is needed. Main focus area is inflammatory disease. of animal and normal human cell systems and related media for in vitro research, serum-free and customized media, sera, growth factors and supplements. Develops cancer vaccines aimed at improving the patients immune response against solid tumours and their metastases. Develop, manufacture and market cell-based cancer diagnostics for both clinical diagnostics and research use. CytoGuide ApS Gustav Wieds Vej 10, DK-8000 Aarhus Tel Cytotech ApS Nordre Strandvej 119F, DK-3150 Hellebaek Tel DanDrit Biotech A/S Symbion Science Park, Fruebjergvej 3, Box 62, DK-2100 Copenhagen Tel Dako A/S Produktionsvej 42, DK-2600 Glostrup Tel Danisco A/S 1989 Produce ingredients for the food industry. The company s broad technology platform and product portfolio include emulsifiers, enzymes, stabilisers, cultures, flavours, sugar and sweeteners. Danisco A/S Langebrogade 1, DK-1001 Copenhagen Tel

6 Direct-Haler A/S 1994 R&D DNA Technology A/S 1992 service Egalet A/S 1987 R&D Research and development of drug delivery device technology, and novel therapeutic approaches involving pulmonary and nasal delivery. Manufactures customer defined oligonucleotides. Research and development is focused on a product line comprised by molecular human diagnostic systems. Focus on the formulation and development of controlled release products. Direct-Haler A/S Symbion Science Park, Tel DNA Technology A/S Science Park Aarhus, Gustav Wieds Vej 10A, DK-8000 Aarhus Tel Egalet A/S Lejrvej 37-41, DK-3500 Vaerloese Tel Eldon Biologicals A/S 1993 Produces blood type determining cards. Eldon Biologicals A/S Sandtoften 10, DK-2820 Gentofte Tel Enfutech ApS 2007 Development ENKAM Pharmaceuticals A/S 2000 R&D Using Retrovec s license for development of potential treatment of HIV patients. Works within the field of neural cell adhesion molecules and has a focus on neurodegenerative disorders and cancer. Enfutech ApS Gustav Wieds Vej 10, DK-8000 Aarhus Tel ENKAM Pharmaceuticals A/S Fruebjergvej 3, Box 58, DK-2100 Copenhagen Tel Entrop Pharma A/S 2007 R&D Develop pharmaceuticals against inflammation. Entrop Pharma A/S Oestergade 5, 3 DK-1100 Copenhagen

7 Entomopharm ApS 2009 R&D Entomopharm is a biotech company developing drug discovery screening models that are based on insects. These models are useful in drug research since they are cost and time efficient, and they reduce the need for an excessive use of animal testing. Entomopharm ApS Lundekærsvej 33, DK-5250 Odense SV Tel EpiTherapeutics ApS 2008 R&D Develops new types of cancer drugs based on research from the University of Copenhagen, Biotech Research and Innovation Center (BRIC). EpiTherapeutics ApS Ole Maaløes Vej 5, DK-2200 Copenhagen Tel Evolva Biotech A/S 2001 R&D Uses genetic engineering to evolve small molecule drugs. Evolva Biotech A/S Bülowsvej 25, DK-1870 Frederiksberg Tel Exiqon A/S 1996 Develops immuno- and molecular genetic-diagnostics, based on immobilization of biomolecules to surfaces and locked nucleic acids. Exiqon A/S Bygstubben 9, DK-2950 Vedbaek Tel FCMB ApS 2005 R&D Develops and commercialises a novel platform that can be used for non-invasive prenatal diagnostics. FCMB ApS Tysklandsvej 7, DK-7100 Vejle Tel Ferring Pharmaceuticals A/S 1992 Develops products in the fields of urology, gynaecology and obstetrics, gastroenterology and endocrinology. Ferring Pharmaceuticals A/S Kay Fiskers Plads 11, DK-2300 Copenhagen Tel Fermenco ApS 2006 Supports the fermentation industry with improvement of industrial micro-organism applied in industrial fermentation processes. Fermenco ApS c/o Technical University of Denmark, Build. 301, DK-2800 Kgs. Lyngby Tel Ferrosan A/S Sydmarken 5, DK-2860 Søborg Tel Ferrosan A/S 1989 Develops medical devices along with dietary supplements containing vitamins, minerals and lactic acid bacteria.

8 Fertin Pharma A/S 2001 Develops medical chewing gum. Fertin Pharma A/S Industrivej 8, DK-7120 Vejle Tel FluimediX ApS 2003 R&D Fluxome Sciences A/S 2002 R&D FluimediX is in the process of developing the NanoCycler device. The NanoCycler will deliver an identification of the presence a number of genetic mutations. Develops innovative and cost-effective bioprocesses by employing metabolic engineering. FluimediX ApS Gregersensvej, building 6, DK-2630 Taastrup Tel Fluxome Sciences A/S Diplomvej 378, DK-2800 Kgs. Lyngby Tel Forward Pharma A/S 2005 R&D Genmab A/S 1999 R&D Develops immunomodulatory drugs for the treatment of a range of common disorders. Main focus is dermatology. Develops human antibodies for the treatment of cancer, infectious disease, rheumatoid arthritis and other inflammatory conditions. Genobiotix ApS 2004 R&D Develops new antibiotics against multi-resistant bacteria. Genzyme Danmark A/S 2002 Genzyme focuses its efforts in medical and technology areas where it can make a major positive impact on the lives of patients with serious diseases and medical conditions. Forward Pharma A/S Østergade 5, 3, DK-1100 Copenhagen Tel: Genmab A/S Toldbodgade 33, P.O. Box 9068, DK-1253 Copenhagen Tel Genobiotix ApS Forskerparken 10, DK-5230 Odense Tel Genzyme Danmark A/S Islands Brygge 57, DK-2300 København S Tel Glycom ApS 2005 R&D Engaged in the preparation of novel biomolecules for the pharmaceutical and food industries. Applies multifunctional molecular engineering and advanced peptide and protein engineering. Glycom ApS Diplomvej 373, DK-2800 Kgs. Lyngby Tel

9 H. Lundbeck A/S 1915 Develops new drugs for treatment of CNS disorders, including depression, schizophrenia, Alzheimer s disease and Parkinson s disease. H. Lundbeck A/S Ottiliavej 9, DK-2500 Valby Tel Health Transmission ApS 2009 R&D Develops a DetecDisc, which are capable of measure relevant blood parameters with antigen precipitation. Health Transmision ApS Noerregade 7 B, DK-1165 Copenhagen Helion Biotech ApS 2008 R&D Develops a recombinant human protein from the innate immune system, MASP-2, for therapeutic use. Helion Biotech ApS Diplomvej 381, DK-2800 Kgs. Lyngby Tel Hemofocus ApS Develops pharmacological inventions that help to decrease bleeding and thereby reduce the need for blood transfusions. Hemofocus ApS Krogshoejvej 41, DK-2880 Bagsvaerd Hypo-Safe A/S 2005 R&D Develops tiny implants that monitor brain activity to convey relevant information and issue alerts, and are currently clinically testing the world s first EEG monitoring device for diabetics. Hypo-Safe A/S Diplomvej 381, DK-2800 Kgs. Lyngby Tel IDS Nordic A/S 1998 Develops therapeutic compounds and diagnostic products for diseases affecting bone and cartilage, such as osteoporosis, osteoarthritis and bone metastasis. IDS Nordic A/S Marielundvej 30, 2., DK-2730 Herlev Tel Ilochip A/S 2001 R&D Develops a micro-device, which provide remote, reliable and rapid detection of biological warfare agents. Ilochip A/S Stroemmen 6, DK-9400 Noerresundby Tel ImmunoSigns A/S 1996 Develops analytical methods based on modern immunotechnology, including microfluidic and microarray analytical methods. ImmunoSigns A/S Henningsens Allé 38, DK-2900 Hellerup Tel

10 Inagen ApS 2007 R&D Development of drugs against virus infections, especially Cytomegalovirus. The drugs consist of toxins bound to signal molecules specifically taken into virus infected cells. Inagen ApS c/o Risoe National Laboratory Frederiksborgvej 399, Building 330, DK-4000 Roskilde Inbicon A/S 2007 R&D Interface Biotech A/S 1998 R&D Develops biomass refineries distinguished by pre-treatment technologies and energy-integration systems. An orthopaedic oriented biotech company specialized in culturing human cells for cartilage and bone repair. Inbicon A/S Kraftvaerksvej 53, Skaerbaek, DK-7000 Fredericia Tel Interface Biotech A/S, Venlighedsvej 6, DK-2970 Hoersholm Tel InXell Bionics ApS 2009 R&D Developing a device that medical companies can utilize in the development of drugs. The device will, among other things, help to test drugs in cells.(awaiting confirmation) InXell Bionics ApS Univeristetsparken 5, DK-2100 Copenhagen LEO Pharma A/S 1908 LICA Pharmaceuticals A/S 2000 R&D LifeCycle Pharma A/S 2002 R&D LiPlasome Pharma A/S 2001 R&D Researches and develops small molecule drug candidates within the fields of dermatology, cardiovascular diseases, antithrombotics, antibiotics, and bone metabolism. Develops novel compounds for the treatment of bacterial and parasitic diseases such as hospital-acquired infections, gastric ulcer and malaria. Develops a drug delivery technology platform for dramatically enhancing the bioavailability of compounds with low water-solubility. Develops novel prodrug and drug delivery systems based on nanocarriers for targeted delivery of anticancer drugs. LEO Pharma A/S Industriparken 55, DK-2750 Ballerup Tel LICA Pharmaceuticals A/S Symbion Science Park, Tel LifeCycle Pharma A/S Kogle Allé 4, DK-2970 Hoersholm Tel LiPlasome Pharma A/S Diplomvej 378, DK-2800 Kgs. Lyngby Tel

11 MC2 Biotek A/S 2006 R&D Develops an innovative, disposable system for the delivery of drugs. MC2 Biotek A/S Tuborg Havnevej 19, DK-2900 Hellerup Tel Meabco A/S 2000 R&D Medical Prognosis Institute ApS 2005 R&D Develops anti-cancer therapeutics based on the combination of metal ions of known therapeutic potential with a novel proprietary pharmaceutical ingredient. Improves cancer treatment with existing and future drugs and radiation treatment. With technology based on DNA microarrays. Meabco A/S Lufthavnsboulevarden T3, DK-2770 Kastrup Tel Medical Prognosis Institute ApS Agern Allé 7, 1, DK-2970 Hoersholm Tel MediCult A/S 1987 Develops new and existing techniques within fertility treatment. MediCult A/S Moellehaven 12, DK-4040 Jyllinge Tel Microlytic ApS 2006 R&D Develops microfluidic technology to speed up the structure determination pipeline for crystallographers. Microlytic ApS Universitetsparken 7, DK-4000 Roskilde Tel Mirrx Therapeutics A/S 2009 R&D Molegro ApS 2005 R&D Holds a fundamental IP to so-called blockmirs, that are capable of blocking single microrna:mrna interactions. Blockmirs can hereby increase synthesis of specific proteins in a human cell, which may lead to a therapeutic or scientific potential. Develops high-performance drug discovery software solutions leading to a faster drug-development process. MycoTeQ A/S 2006 R&D Discovers and develops novel natural antibiotics from microfungi. Mirrx Therapeutics A/S Diplomvej 378, DK-2800 Kgs.Lyngby Molegro ApS Høegh-Guldbergs Gade 10, Building 090, DK-8000 Aarhus Tel MycoTeQ A/S Søltofts Plads 221, DK-2800 Kgs. Lyngby Tel

12 NatImmune A/S 2000 R&D Nensius Research A/S 2004 R&D Neoloch ApS 2008 R&D Neurokey A/S 2007 R&D NeuroSearch A/S 1988 R&D Develop protein-based therapeutics for the prevention and treatment of infectious diseases and inflammation. Focus in on pre-clinical research within neurodegenerative diseases with the mission to design pharmacologically active compounds capable of protecting and regenerating nerves Pharmaceutical company focused on developing drugs for treatment of inflammation, cancer and neurodegeneration Develops drugs for the critical care segment. Neurokey products are based on both original ideas and in-licensing. Develops novel drugs, based on unique and broad drug discovery platform focusing on ion channels and CNS disorders for the treatment of ADHD, cancer, epilepsy, and Parkinson's disease. NatImmune A/S Fruebjergvej 3, box 3, DK-2100 Copenhagen Tel Nensius Research A/S Symbion Science Park Tel Neoloch ApS Tonysvej 20, DK-2920 Charlottenlund Tel Neurokey A/S Diplomvej 381, DK-2800 Kgs Lyngby Tel NeuroSearch A/S Pederstrupvej 93, DK-2750 Ballerup Tel Nordic Bioscience A/S 2001 R&D Nordic Vaccine A/S 2001 R&D Developing novel treatments and diagnostics for the improved management of patients with chronic, degenerative diseases, such as osteoporosis. Develops vaccines for prophylactic as well as therapeutic use. Focused on vaccines for infectious diseases, DNA-delivery technologies for use in therapeutic DNA-vaccines and gene therapy. Nota Bene Scientific ApS 1990 Produces antibodies and other immunology reagents. Nordic Bioscience A/S Herlev Hovedgade 207, DK-2730 Herlev Tel Nordic Vaccine A/S Symbion Science Park, Tel Nota Bene Scientific ApS Nordre Strandvej 119F, DK-3150 Hellebaek Tel

13 Novo Nordisk A/S 1923 Focuses on diabetes treatment and insulin delivery systems. The company is also involved within areas such as haemostasis management, growth hormone therapy and hormone replacement therapy. Novo Nordisk A/S Novo Allé, DK-2880 Bagsvaerd Tel Novozymes A/S 1941 Develops and refines enzymes and microorganisms to improve industrial performance with focus on microbiology, biotechnology and gene technology. Novozymes A/S Krogshoejvej 36, DK-2880 Bagsvaerd Tel: NSexplorer A/S 2002 R&D Focuses on new mechanisms for the treatment of tension type headache. NSexplorer A/S Pederstrupvej 93, DK-2750 Ballerup Tel NsGene A/S 1999 R&D Nuevolution A/S 2001 R&D Nycomed Danmark A/S 1922 R&D Orphazyme ApS 2009 R&D Pcovery ApS 2009 R&D Develops novel cell and gene based products for the treatment of neurological diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain. Develops a unique drug discovery technology that enables the rapid synthesis and screening of many billions of drug-like molecules in a single test tube. Nycomed is a privately owned global pharmaceutical company with a differentiated portfolio focused on branded medicines in gastroenterology, respiratory and inflammatory diseases, pain, osteoporosis and tissue management. An extensive range of OTC products completes the portfolio. Focus on innovation and development of a novel therapeutic strategy for the treatment of lysosomal storage diseases Focus on structure based drug development against membrane protein drug targets. NsGene A/S Baltorpvej 154, DK-2750 Ballerup Tel Nuevolution A/S Rønnegade 8, DK-2100 Copenhagen Tel Nycomed Danmark A/S Langebjerg 1, DK-4000 Roskilde Tel Orphazyme ApS Ingemannsvej Th., DK1964 Frederiksberg Tel Pcovery ApS Gustav Wieds Vej 10 C, DK-8000 Aarhus Tel

14 Pentabase ApS 2006 Develops and manufactures diagnostic products using Real time PCR technologies. Pharma 2100 ApS 2004 R&D Develops products for wound treatment. Pentabase ApS Sunekaer 1, DK-5471 Soendersoe Tel Pharma 2100 ApS Symbion Science Park, Tel Pharmacosmos A/S 1965 Manufactures and develops intravenous iron infusion and iron injection compounds and Dextran carbohydrate polymers, which are essential in the treatment of anaemia in humans. Pharmacosmos A/S Rørvangsvej 30, DK-4300 Holbaek Tel Pharmos Bioscience A/S 2004 R&D Focused on bone diseases. Pharmos Bioscience A/S Ballerup Byvej 222, DK-2750 Ballerup Tel Phlogo ApS 2008 R&D Develops peptides for the treatment of inflammatory diseases Phlogo ApS Soemarksvej 11, DK-2900 Hellerup Tel Pipeline Biotech A/S 1999 R&D service PK Chemicals A/S 1991 A pharmacological contract research organisation with the capacity to combine advanced molecular biology with pre-clinical research, aimed at drug discovery and early drug development. Manufactures Dextran derivatives and other carbohydrate-based chemicals. Pipeline Biotech A/S Roevedvej 1, DK-8380 Trige Tel PK Chemicals A/S Koebenhavnsvej 140, DK-4600 Koege Tel Poalis A/S 2001 R&D Develops biological production processes for aromas and other high value chemicals. Poalis A/S Kirkeleddet 125, DK-3480 Fredensborg Tel

15 Poseidon Pharmaceuticals A/S 2001 R&D PreciSense A/S 1995 R&D Pronova Biopharma Danmark A/S 2004 R&D ProteoTarget ApS 2002 R&D Researches and develops therapies for diseases outside the CNS area. PreciSense A/S develops a novel glucose sensor for minimally invasive measurement of blood glucose of diabetic patients. Pronova Biopharma produces one product Omacor/Lovaza, which is prescribed as an adjunct to diet for the treatment of elevated levels of triglycerides in humans, and it is also approved in certain markets for the secondary prevention of post-myocardial infarction. Develops a novel phage display technology platform to accelerate drug discovery and to allow targeting of intracellular proteins. Poseidon Pharmaceuticals A/S Pederstrupvej 93, DK-2750 Ballerup Tel PreciSense A/S Doktor Neergaards Vej 3, DK-2970 Hørsholm Tel Pronova Biopharma Danmark A/S Juelsmindevej 5, DK-4400 Kalundborg Tel ProteoTarget ApS Tranbjerg Stationsvej 1, DK 8310 Tranbjerg Tel.: ProZymex Pharmaceuticals A/S 1999 R&D Researches in DPPI and DPPI inhibitors for disease treatment. ProZymex Pharmaceuticals A/S Dr. Neergaards Vej 17, DK-2970 Hoersholm Tel Quantibact A/S 2004 R&D RAM Biotech ApS 2003 R&D Develops a new method for measuring the number and the sort of bacteria in urine. Develops therapeutical anti-malaria antibodies with the potential to eliminate the malaria parasite at the merezoite stage. Quantibact A/S Kettegaars Allé, Pavillion 5, DK-2650 Hvidovre Tel RAM Biotech ApS Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Tel Reapplix ApS 2008 R&D Identifies blood-derived proteins that improve wound healing, to isolate them, and to reapply them to patients with chronic wounds. Reapplix ApS Julmosevej 10B, DK-3460 Birkeroed Tel

16 ReceptIcon ApS 2001 R&D RefLab ApS 1991 production Focuses on discovery of receptors in the kidney that are responsible for renal uptake and nephrotoxicity of some of the most commonly used therapeutics worldwide. Produces and distributes allergy diagnostic test kits. RetroVec ApS 2004 R&D Develops retroviral gene transfer technology. ReceptIcon ApS Gustav Wieds Vej 10, DK-8000 Aarhus Tel: RefLab ApS Tagensvej , DK-2200 Copenhagen Tel RetroVec ApS c/o Østjysk Innovation A/S, Gustav Wieds Vej 10, DK-8000 Aarhus Tel RhoVac ApS 2008 R&D Focuses on the development of innovative and highly potent therapeutic cancer vaccines. RhoVac ApS Agern Alle 3, DK-2970 Hoersholm RiboTask ApS 2006 Service Offers RNA- and LNA-based products to companies within biotechnology and to academic research laboratories. The products down regulate disease-promoting genes and hereby stop the development of the sick cells. RiboTask ApS Sdr. Boulevard 44, 3., DK-5000 Odense Tel Rosco Diagnostica A/S 2002 production Develops and manufactures a system for antimicrobial susceptibility testing and identification of bacteria and yeasts. Rose Pharma A/S 2003 R&D Develops therapeutics based on gastrointestinal peptide hormones. Sanos Bioscience A/S 2003 R&D Focuses on diseases involving skeletal wasting such as osteoporosis. Rosco Diagnostica A/S Taastrupgaardsvej 30, DK-2630 Taastrup Tel Rose Pharma A/S Symbion Science Park Tel Sanos Bioscience A/S Glerupvej 2, DK-2610 Roedovre Tel

17 Santaris Pharma A/S 2003 R&D Develops cancer treatments using high affinity LNA antisense chemistry. Schafer-N ApS 1995 Synthesizes custom defined peptides. SD Genomics A/S 2006 Service Specializes in providing biotechnological products and services including oligonucleotides, sequencing services, bioinformatics services, and microarrays. Santaris Pharma A/S Bøge Allé 3, DK-2970 Horrsholm Tel Schafer-N ApS Lersø Park Allé 42, DK-2100 Copenhagen Tel SD Genomics A/S Science Park Aarhus Gustav Wieds Vej 10, DK-8000 Aarhus Tel Senetek Denmark ApS 2005 R&D Development of products in both the anti-aging and sexual dysfunction categories. Senetek Denmark ApS Gustav Wieds Vej 10, DK-8000 Aarhus Serendex ApS 2007 Development Using Retrovec s license for development of a potential HIV vaccine. Serendex ApS Scion-DTU Agern alle 3, DK-2970 Hoersholm Tel Sentinext Therapeutics ApS 2009 R&D SKAUvaccine ApS 2007 Development Develops a vaccine against the infection disease EV71 (enterovirus 71), which causes annual epidemics particularly in the tropic countries Files use-patents on well known already approved and marketed drugs in new indications for treatment of critical ill patients. Sentinext Therapeutics ApS Tel SKAUvaccine ApS Gustav Wieds Vej 10, DK-8000 Aarhus Tel Soilrem A/S 1986 Biotechnological cleaning of contaminated soil by bioremediation, electro dialysis and organic solvents. Bioteknisk Jordrens Soilrem A/S Maglehoejvej 10, DK-4400 Kalundborg Tel

18 Sophion Bioscience A/S 2000 Develops and produces Microchip-based automated patch clamp systems. Sophion Bioscience A/S Baltorpvej 154, DK-2750 Ballerup Tel Sound Biotech ApS 2008 R&D Focuses on finding treatments for inflammatory diseases, pain and metabolic diseases. Sound Biotech ApS Tuborg Havnevej 18, DK-2900 Hellerup Spree Pharma A/S 2007 Development Reformulates a number of compounds in focused therapeutic indication using iceutica s proprietary Encapsulated Organic Nanoparticle Platform. Spree Pharma A/S Oestergade 5, 3, DK-1100 Copenhagen Statens Serum Institut 1902 Prevents and controls infectious diseases, biological threats, and congenital disorders. Statens Serum Institut Artillerivej 5, DK-2300 Copenhagen Tel Stevia ApS 2007 R&D Stealth Biotech ApS 2007 R&D Develops a pharmaceutical therapy for diabetes type 2 and the metabolic syndrome, based on molecular structures found in the plant stevia rebaudiana. Holds intellectual property rights to a new class of antisense compounds, so-called blockmirs. Blockmirs are capable of interfering with microrna based gene regulation with exceptional precision, such as to exclusively affect the synthesis of the protein encoded the target mrna of the blockmir. Symphogen A/S 2000 R&D Develops recombinant human polyclonal antibodies. TAG Copenhagen A/S 1996 Develops instruments and software for DNA and peptide synthesis. Stevia ApS Sponnecksvej 4, DK-2820 Gentofte Tel Stealth Biotech ApS Sluseholmen 2-4, DK-2450 Copenhagen Symphogen A/S Elektrovej Building 375, DK-2800 Kgs. Lyngby Tel TAG Copenhagen A/S Symbion Science Park, Tel

19 TD Vaccines A/S 2009 R&D Terranol A/S 2007 R&D Focus on development of vaccines to protect against Travellers Diarrhoea. Lead program in portfolio is ACE527 an oral ETEC(enterotoxigenic E. coli) vaccine. Terranol will indtroduce a C5-sugar fermenting system into the organism yeast, and hereby significantly increase the yield of ethanol. TD Vaccines A/S Aspvej 12, DK-9520 Skørping Tel Terranol A/S c/o DTU Systems Biology, Building 223, DK-2800 Kgs. Lyngby Tel Thrombologic ApS 2009 R&D TopoTarget A/S 2000 R&D Unizyme Laboratories A/S 1989 service Valderm ApS 2003 R&D Vipergen ApS 2005 R&D Spin out from Rigshospitalet. The company is focusing on a novel treatment for intensive care unit patients suffering from thrombocytopenia associated organ failure. Develops cancer treatment drugs which target key molecular mechanisms associated with the cell cycle, chromatin control and DNA damage. Develops proteins with main focus on peptidases for use in downstream processing, peptide synthesis and drug discovery. Develops anthracyclines into topical formulations for treatment of hyperproliferative skin diseases. Develops a drug discovery technology platform providing access to small molecule combinatorial libraries of up to compounds. Thrombologic ApS Blegdamsvej 106b, 2tv, DK-2100 Copenhagen Tel TopoTarget A/S Symbion Science Park, Tel Unizyme Laboratories A/S Dr. Neergaardsvej 17, DK-2970 Hoersholm Tel Valderm ApS Lundtoftevej 277, DK-2800 Kgs. Lyngby Tel: Vipergen ApS Gammel Kongevej 23 A1, DK-1610 Copenhagen Tel

20 ViroGates A/S 2000 R&D Focused on HIV research and disease prognostics. Zealand Pharma A/S 1998 R&D Develops peptide-based drugs that target diseases and symptoms. ViroGates A/S Scion-DTU Diplomvej 377, DK-2800 Kgs. Lyngby Tel Zealand Pharma A/S Smedeland 26 B, DK-2600 Glostrup Tel ZGene A/S 2001 R&D Zymenex A/S 1998 R&D 2CureX ApS 2006 R&D 7 TM Pharma A/S 2000 R&D Develops a technology that enhances the effect of current anticancer drugs and reduces their toxicity. Develops innovative therapeutics for life threatening diseases such as lysosomal storage diseases. Develops drug candidates for the treatment of cancer with focus on colon and neuronal cancer. Develops novel drugs for 7TM receptor targets with therapeutic focus on metabolic disorders, including obesity, and inflammatory disorders, targeting allergic rhinitis and asthma. ZGene A/S Pederstrupvej 93, DK-2750 Ballerup Tel Zymenex A/S Roskildevej 12 C, DK-3400 Hilleroed Tel CureX ApS Birkevej 37, DK-3460 Birkeroed Tel TM Pharma A/S Fremtidsvej 3, DK-2970 Hoersholm Tel