STTR PROGRAMMATIC INVESTMENT GRANT APPLICATION

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1 2016 STTR PROGRAMMATIC INVESTMENT GRANT APPLICATION Application Deadline: November 16, 2015 November 30, 2015 BLADDER BRAIN BREAST COLORECTAL HEAD & NECK LUNG OVARY PANCREAS PROSTATE SARCOMA

2 APPLICATION REQUIREMENTS Solid Tumor Translational Research (STTR) Programmatic Investment Grants Opportunity: Three $333,333 grants across 3 years are available to STTR faculty and their collaborators. Requirements: Proposals must be innovative and collaborative translational research projects with clear hypotheses, aims and outcomes to propel the field. Projects must be outside the scope of our current portfolios for NIH Program Projects, SPOREs, etc. Consideration given to faculty with different R01s (or similar granting types) who come together to create a programmatic focus. Favorable scoring will be given to projects that articulate a clear plan to move to a clinical trial, new screenings or guidelines within the next five (5) years. STTR will release $333,333 direct cost awards, with no additional F&A (at UW/UWMedicine, it is up to you to consult the sign-off process for awards received without F&A as per your departmental guidelines. At Fred Hutch, awardees are approved to use the funds for direct cost, salary and fringe). At least 50% of the award must be used at Fred Hutch. Dollars are unrestricted and/or can be used to hire full-time positions utilized between the team (i.e. tech, post doc, etc.). Year 2 funding is contingent upon submitting a progress report. Year 3 funding is contingent upon the team s submission to a large granting mechanism (i.e. NIH, DOD, etc.). NOTE: STTR staff can offer support for grant submission. Staffing: Teams must be translational and multi-disciplinary. Each team must include one PI who is a STTR member with a primary Fred Hutch appointment and at least two other STTR faculty from other disciplines and/or institutional appointment. Possible collaborations might include research scientists and clinicians. APPLICATION SUBMISSION IMPORTANT DATES LOI Decisions / Invitations for Full Proposals October 9, 2015 Application Deadline ** November 16, 2015 November 30, 2015 Applicants Notified of Award January 5, 2016 STTR Conference / Retreat Presentation of Results TBD ** UW Investigators: Final applications must be submitted to OSP three full business days before the submission deadline, per UW policy (GIM 19) Completed applications must be submitted electronically in a single PDF document to Jalle Gebisa, Research Coordinator, STTR All documents are due by 11:59 pm PT on the deadline date. 1

3 2016 STTR PROGRAMMATIC INVESTMENT GRANT FUNDING APPLICATION FORM Instructions: For each section, select all that appropriately describe the scope of the project. POPULATION: Pediatric Adult Both MODALITY: STTR CANCER TYPES INCLUDED: PATIENT INVOLVEMENT: Biomarkers, Imaging Cancer Metabolism Diagnostics Early Detection Genomics Immunotherapy Novel Therapeutics Outcomes/Efficacy Population Research Precision Medicine Other: Bladder Breast Head & Neck Ovary Prostate Brain Colorectal Lung Pancreas Sarcoma Clinical Trials Clinical Trials within 5 years Co-Clinical Trials Pre-Clinical Trials Interventional Public Health Study Screening Practices Updated Guidelines Other: Project Title: Project Team: Name Primary Appointment (Fred Hutch or UW/UWM) Department / Division PI / Co-PI, Co-I, or Key P PI Coordinator/ Assistant s Name Phone Number Name of PI Supported by Coordinator 2

4 ABSTRACT: The abstract should be 250 words or less. LAYMAN PROPOSAL: DO NOT exceed one page of text; the image can be on the second page. 1. Explain the significance of the research to the community, patient or disease. Language used must be at a high school reading level. This document will be used for reviewers outside of your field, to distribute to potential donors via the FH Development and UWM Advancement Offices and, possibly, via the marketing departments at both institutions on the website to garner more exposure for your research. 2. Include one image or diagram to represent your proposal. Please keep in mind that this image will be sent to potential donors and should be appropriate for a lay audience. SCIENTIFIC PROPOSAL: DO NOT exceed six (6) pages for this section, including pictures, tables and figures. 1. Specific Aims 2. Background and Significance 3. Preliminary Data 4. Methods and Strategies (Attach your approved or draft protocol, if available, in Additional Information ) 5. Timeline 6. Tables and Figures ADDITIONAL INFORMATION: 1. Programmatic Influence: A single paragraph on the programmatic aspects of this work and how it fits in the context of the overall cancer type research portfolio across our Cancer Consortium 2. Proposed Granting Mechanism: If a NIH grant has already been identified to apply for in Year 2, please include the name of the particular granting mechanism you envision applying for to meet the requirement for Year 3 funding. 3. References 4. Biographical Sketch: Use the NIH format enclosed on page 6 or at this link: 5. IRB Protocol (if applicable) BUDGET: Funding duration is three years. Proposals for $333,333 grants must include three STTR faculty from different disciplines (one PI must have a primary Fred Hutch appointment). At least 50% of the award each year must be used at Fred Hutch. Requests for funding to hire new staff or pay for shared post docs are encouraged. Here are the instructions for completing the budget forms: 1. Submit a detailed budget ($111,111) for the first year. The budget period for Year 1 is January 1, 2016 December 31, Use the NIH format found on page 4 or at this link: 2. Submit a budget for the entire proposed project period ($111,111/year for 3 years). Use the NIH format found on page 5 or at this link: 3. Complete a budget form for each institution. For example, if funds are going to University of Washington, then complete a separate budget form showing what funds will be sent to UW as a subaward. 4. Include detailed justifications. 3

5 Program Director/Principal Investigator (Last, First, Middle): DETAILED BUDGET FOR INITIAL BUDGET PERIOD List PERSONNEL (Applicant organization only) Use Cal, Acad, or Summer to Enter Months Devoted to Project Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits FROM THROUGH NAME ROLE ON PROJECT Cal. Mnths Acad. Mnths Summer Mnths INST.BASE SALARY SALARY REQUESTED FRINGE BENEFITS TOTAL PD/PI SUBTOTALS CONSULTANT EQUIPMENT (Itemize) SUPPLIES (Itemize by category) TRAVEL INPATIENT CARE OUTPATIENT CARE ALTERATIONS AND RENOVATIONS (Itemize by category) OTHER EXPENSES (Itemize by category) CONSORTIUM/CONTRACTUAL DIRECT SUBTOTAL DIRECT FOR INITIAL BUDGET PERIOD (Item 7a, Face Page) $ CONSORTIUM/CONTRACTUAL FACILITIES AND ADMINISTRATIVE TOTAL DIRECT FOR INITIAL BUDGET PERIOD $ PHS 398 (Rev. 08/12) OMB No

6 Program Director/Principal Investigator (Last, First, Middle): BUDGET FOR ENTIRE PROPOSED PROJECT PERIOD DIRECT ONLY BUDGET CATEGORY TOTALS INITIAL BUDGET PERIOD (from Form Page 4) 2nd ADDITIONAL YEAR OF SUPPORT REQUESTED 3rd ADDITIONAL YEAR OF SUPPORT REQUESTED PERSONNEL: Salary and fringe benefits. Applicant organization only. CONSULTANT EQUIPMENT SUPPLIES TRAVEL INPATIENT CARE OUTPATIENT CARE ALTERATIONS AND RENOVATIONS OTHER EXPENSES DIRECT CONSORTIUM/ CONTRACTUAL SUBTOTAL DIRECT (Sum = Item 8a, Face Page) F&A CONSORTIUM/ CONTRACTUAL TOTAL DIRECT TOTAL DIRECT FOR ENTIRE PROPOSED PROJECT PERIOD JUSTIFICATION. Follow the budget justification instructions exactly. Use continuation pages as needed. $ PHS 398 (Rev. 08/12) OMB No

7 OMB No /0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: era COMMONS USER NAME (credential, e.g., agency login): POSITION TITLE: EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE (if applicable) Completion Date MM/YYYY FIELD OF STUDY A. Personal Statement Briefly describe why you are well-suited for your role in the project described in this application. The relevant factors may include aspects of your training; your previous experimental work on this specific topic or related topics; your technical expertise; your collaborators or scientific environment; and your past performance in this or related fields (you may mention specific contributions to science that are not included in Section C). Also, you may identify up to four peer reviewed publications that specifically highlight your experience and qualifications for this project. If you wish to explain impediments to your past productivity, you may include a description of factors such as family care responsibilities, illness, disability, and active duty military service. B. Positions and Honors List in chronological order previous positions, concluding with the present position. List any honors. Include present membership on any Federal Government public advisory committee. C. Contribution to Science Briefly describe up to five of your most significant contributions to science. For each contribution, indicate the historical background that frames the scientific problem; the central finding(s); the influence of the finding(s) on the progress of science or the application of those finding(s) to health or technology; and your specific role in the described work. For each of these contributions, reference up to four peer-reviewed publications or other nonpublication research products (can include audio or video products; patents; data and research materials; databases; educational aids or curricula; instruments or equipment; models; protocols; and software or netware) that are relevant to the described contribution. The description of each contribution should be no longer than one half page including figures and citations. Also provide a URL to a full list of your published work as found in a publicly available digital database such as SciENcv or My Bibliography, which are maintained by the US National Library of Medicine. D. Research Support List both selected ongoing and completed research projects for the past three years (Federal or non-federallysupported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs. 6

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