Fire Sessions 13 Posters 22

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2 INDEX 2

3 WELCOME 4 ORGANIZATION 5 JANSSEN PRIZE 6 TRAVEL GRANTS 7 SPONSORS 8 PROGRAM 9 Fire Sessions 13 Posters 22 PLENARY LECTURES 29 ORAL COMMUNICATIONS 36 Symposium I Neurodevelpment 37 Symposium II Communication in the nervous system 44 Symposium III Cognition and behaviour 51 Symposium IV New targets for nervous system therapy 58 FIRE SESSIONS I 65 Neurogenesis and neural cell differentiation 66 Cell signaling I 79 Neurodegeneration and neuroprotection I 92 FIRE SESSIONS II 105 Neural systems I 106 Cell signaling II 119 Neurodegeneration and neuroprotection II 132 FIRE SESSIONS III 145 Neural systems II 146 Neuroinflammation 159 Neurodegeneration and neuroprotection III 172 POSTERS 185 Neurodegeneration and neuroprotection 186 Cell signaling 224 Neurogenesis and neural cell differentiation 247 Neuroinflammation 254 Neural systems 259 3

4 Caros Sócios da SPN, Sejam bem-vindos à XIII Reunião da Sociedade Portuguesa. A Comissão Organizadora, a quem desde já agradeço, preparou um excelente programa de trabalhos, que seguramente estimulará uma profícua troca de ideias entre todos. E todos, desta feita, serão cerca de 300 delegados, com mais de 80 posters e de 100 fire-talks com posters. A reforçar esta participação, é com enorme alegria que vos informo do aumento exponencial do número de sócios, o que bem demonstra a dinâmica da nossa comunidade de neurocientistas. Estão, portanto, reunidas as condições para uma ótima reunião. Aproveitem e Divirtam-se! Abraço Nuno Sousa 4

5 Organizing Committee: Ana Luísa Carvalho (CNC, University of Coimbra) Ana Paula Silva (IBILI, University of Coimbra) Ana Raquel Santiago (IBILI, University of Coimbra) A. Francisco Ambrósio (IBILI, University of Coimbra) Cláudia MF Pereira (CNC, University of Coimbra) Dan Brudzewsky (IBILI, University of Coimbra) Elisabete Ferreiro (CNC, University of Coimbra) João Malva (University of Coimbra, Coimbra) Jorge Valero (CNC, University of Coimbra) Liliana Bernardino (HealthSciencesResearchCenter, University of Beira Interior) Maria H. Madeira (IBILI, University of Coimbra) Paula Moreira (CNC, University of Coimbra) Sandra M Cardoso (CNC, University of Coimbra) Advisory Board: Alexandre Ribeiro (University of Lisbon) António Freire (University of Coimbra) Arsélio Pato de Carvalho (University of Coimbra) Catarina Oliveira (University of Coimbra) Deolinda Lima (University of Porto) Domingos Henrique (University of Lisbon) Isabel Santana (University of Coimbra) José Castro Lopes (University of Lisbon) Zachary Mainen (Champalimaud Foundation, Lisbon) Scientific Committee: Alexandre Castro Caldas (University of Lisbon) Ana Cristina Rego (University of Coimbra) Ana Sebastião (University of Lisbon) Carlos Jorge Duarte (University of Coimbra) Cecília Rodrigues (University of Lisbon) Graça Baltazar (University of Beira Interior) Inês Araújo (University of Algarve) Isaura Tavares (University of Porto) João Laranjinha (University of Coimbra) João Relvas (University of Porto) Luís Almeida (University of Coimbra) Miguel Castelo-Branco (University of Coimbra) Mónica Sousa (University of Porto) Nuno Sousa (University of Minho) Odete Cruz e Silva (University of Aveiro) Patrícia Maciel (University of Minho) Rodrigo Cunha (University of Coimbra) Rui Costa (Champalimaud Foundation, Lisbon) Tiago Outeiro (University of Lisbon) 5

6 JANSSEN PRIZE 6

7 TRAVEL GRANTS Ana M Oliveira (University of Heidelberg, Germany) Ana Saavedra (University of Barcelona, Spain) Bruno Godinho (University College Cork, Ireland) Mónica Santos (Center for Genomic Regulation, Barcelona, Spain) Raquel Pinho (University Medical Center Göttingen, Germany) Rita Teodoro (Harvard Medical School, Boston, USA) Rui Peixoto (Harvard Medical School, Boston, USA) Susana da Silva (Harvard Medical School, Boston, USA) 7

8 SPONSORS 8

9 PROGRAM 9

10 May 30 13h45 Registration 14h45 15h00 Opening Session 15h00 16h00 Plenary Lecture I Chairperson: Catarina Resende Oliveira PL1 Miguel Castelo Branco (IBILI, Coimbra, PORTUGAL) Systems Neurobiology: New Trends in Translational Neuroscience 16h00 18h30 Symposium I Neurodevelopment Chairpersons: João Relvas and Patrícia Maciel 16h00 SI1 Susana da Silva (Harvard Medical School, Boston, USA) Searching the source of topography in the somatosensory system. Role of periphery TGF β signaling in barrelette development 16h30 SI2 Pedro Brites (IBMC, Porto, PORTUGAL) Ether phospholipid functions on Schwann cell differentiation and myelination 17h00 SI3 Domingos Henrique (IMM, Lisbon, PORTUGAL) Understanding cell fate decisions in the embryonic neural retina 17h30 SI4 Márcia Almeida Liz (IBMC, Porto, PORTUGAL) Neuronal deletion of GSK3β increases microtubule dynamics in the growth cone enabling axonal regeneration 18h00 SI5 Joana Paes de Faria (IBMC, Porto, PORTUGAL) Profilin1 regulates PNS myelination 18h15 SI6 Joana M. Marques (Instituto de Neurociencias de Alicante, SPAIN) CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development 18h30 18h45 Coffee Break 18h45 19h45 Fire Session I Neurogenesis and neural cell differentiation / Cell signaling I / Neurodegeneration and neuroprotection I 19h45 20h05 Prémio Janssen Neurociências Reception 10

11 May 31 09h00 11h30 Symposium II Communication in the nervous system Chairpersons: Ana Sebastião and Carlos Duarte 09h00 SII1 Ana Saavedra (University of Barcelona, SPAIN) BDNF regulates striatal enriched protein tyrosine phosphatase levels in cortical neurons 09h25 SII2 Rita Teodoro (Harvard Medical School, Boston, USA) Ral mediates activity dependent growth of postsynaptic membranes via recruitment of the exocyst 09h50 SII3 Rui Peixoto (Harvard Medical School, Boston, USA) Trans synaptic signaling by cleavage of Neuroligin 1 10h15 SII4 Ana Luísa Carvalho (CNC, Coimbra, PORTUGAL) Modulation of hippocampal glutamatergic synapses by ghrelin 10h45 SII5 Luísa V. Lopes (IMM, Lisbon, PORTUGAL) Clues to the early aging of the hippocampus Impact on cognition 11h15 SII6 Diogo Rombo (IMM, Lisbon, PORTUGAL) Adenosine A2A receptors mediate hippocampal network disinhibition specifically through parvalbumin expressing interneurons 11h30 12h00 Coffee Break 12h00 13h00 Plenary Lecture II Chairperson: Ana Luísa Carvalho PL2 Daniel Choquet (Institut Interdisciplinaire de Neuroscience, Bordeaux, FRANCE) A nanoscale view into the dynamic of AMPA receptor organization in synapses 13h00 15h00 Lunch/Posters 15h00 17h30 Symposium III Cognition and behaviour Chairpersons: Alexandre Castro Caldas and Rui Costa 15h00 SIII1 Mónica Santos (Center for Genomic Regulation, Barcelona, SPAIN) Hippocampal hyperexcitability and impaired ERK signaling underlie enhanced and extinction resistant fear memories in a mouse overexpressing TrkC, a model of panic disorder 15h30 SIII2 Ana M. Oliveira (University of Heidelberg, GERMANY) Rescue of aging associated decline in Dnmt3a2 expression restores cognitive abilities 16h00 SIII3 Tiago V. Maia (University of Lisbon, PORTUGAL) Reinforcement learning in avoidance, habits, and tics 16h30 SIII4 Marta Moita (Champalimaud Foundation, Lisbon, PORTUGAL) Listening to the sound of silence 17h00 SIII5 Henrique Sequeira (University of Lille, FRANCE) Affective brain networks: a neurodynamic approach 17h15 SIII6 Jorge Valero (CNC, Coimbra, PORTUGAL) Long term effects of an acute administration of lipopolysaccharide on spatial memory and adult neurogenesis in the triple transgenic mouse model of Alzheimer's disease 17h30 18h00 Coffee Break 18h00 18h30 18h30 19h00 19h00 20h00 20h00 Dinner Prémios Artigo Destaque SPN_2012 & SPN_2013 Sponsored by Bayer Horizon 2020 and Neuroscience Research FCT SPN General Assembly 11

12 June 1 09h00 10h00 Plenary Lecture III Chairperson: Nuno Sousa PL3 Óscar Marín (Instituto de Neurociencias de Alicante, SPAIN) Neurodevelopment and Nervous System Diseases: Molecular mechanisms controlling the development of cortical interneurons 10h00 11h00 Fire Session II Neural systems I / Cell signaling II / Neurodegeneration and neuroprotection II 11h00 11h30 Coffee Break 11h30 12h30 Fire Session III Neural systems II / Neuroinflammation/ 12h30 14h30 Neurodegeneration and neuroprotection III Lunch/Posters 14h30 17h00 Symposium IV New targets for nervous system therapy Sponsored by the Portuguese Biochemical Society (SPB) Chairpersons: João Laranjinha and Tiago Outeiro 14h30 SIV1 Juan P. Bolaños (University of Salamanca, SPAIN) Bioenergetics and Antioxidant Coupling in the Nervous System 15h00 SIV2 Raquel Pinho (University Medical Center Göttingen, GERMANY) Understanding the role of alpha synuclein in the nucleus: a new concept in synucleinopathies 15h30 SIV3 Patrícia Maciel (ICVS, Braga, PORTUGAL) Pharmacotherapy for Machado Joseph disease: from worm to mouse to human? 16h00 SIV4 Ana I. Duarte (CNC, Coimbra, PORTUGAL) Insulin/IGF 1/estrogen signalling protects against lipid oxidation and neurodegenerative events in type 2 diabetic female rat brain 16h30 SIV5 Teresa Summavielle (IBMC, Porto, PORTUGAL) The role of acetyl L carnitine in the brain glucose uptake under methamphetamine 16h45 SIV6 Bruno M.D.C. Godinho (University College Cork, IRELAND) A Nanotoxicological Appraisal of Non viral vectors for RNA Interference in the CNS 17h00 18h00 Awards & Closing 12

13 Fire Sessions Fire Sessions I Neurogenesis and neural cell differentiation May 30 Bussaco room Chairperson: Jorge Valero 18:45H FIA1 Santos AI, Carreira BP, Ribeiro LF, Morte MI, Carvalho CM, Martínez-Ruiz A, Araújo IM. p21ras: a target for NO to enhance neurogenesis. 18:50H FIA2 Xavier JM, Morgado AL, Solá S, Rodrigues CMP. p53 Modulates Differentiation-induced Mitochondrial Damage and Promotes Neurogenesis. 18:55H FIA3 Morgado AL, Xavier JM, Solá S, and Rodrigues CM. mir-34a Regulates Autophagy and Neuronal Differentiation During Neural Stem Cell Differentiation. 19:00H FIA4 Barateiro A, Domingues H, Miron V, Tukey RH, Santos S, ffrench-constant C, Relvas J, Fernandes A, Brites D. Unconjugated bilirubin dysregulates oligodendrocyte development and myelinogenesis. 19:05H FIA5 Xapelli S, Agasse F, Ribeiro FF, Bernardino L, Schitine CS, Heimann A., Ferro ES, De Melo Reis RA, Sebastião AM, Malva JO. Hemopressin stimulates oligodendrogenesis in neural stem cell cultures from the subventricular zone. 19:10H FIA6 Domingues HS, Faria JP, Relvas J. The Processossome : identification and characterization of proteins promoting oligodendrocyte process outgrowth and (re)myelination. 19:15H FIA7 Falcão AS, Gomes C, Santos G, Brites D. The Dark Side of Neural Precursor Cells: New Cues for Gliomagenesis. 19:20H FIA8 Patrício P, Pinheiro A, Alves ND, Morais M, Santos AR, Bessa J, Irmler M, Beckers J, Sousa N, Pinto L. Genome-wide characterization of the adult hippocampal neurogenic niche regulators in depression and by antidepressant drugs: Cellular and molecular. 19:25H FIA9 Mateus-Pinheiro A, Patrício P, Morais M, Alves ND, Monteiro S, Almeida OFX, Bessa J, Sousa N, Pinto L. The interplay between dendritic plasticity and cell genesis in depression. 19:30H FIA10 Mendonça L, Nóbrega C, Kaspar B, Pereira de Almeida L. Neural stem cells survive, differentiate and alleviate the motor phenotype of Machado-Joseph disease transgenic mice upon cerebellar transplantation. 19:35H FIA11 Ferreiro E, Valero J, Bernardino L, Pereira C, Agasse F. Imbalance in the stem/progenitor cells properties leads to the suppression of neurogenesis in the triple transgenic mouse model of Alzheimer s disease. 19:40H FIA12 Neto E, Aguiar P, Almeida R, Lamghari M. Peripheral nervous system and bone: Advanced tools to study an essential interaction. 13

14 Cell signaling I May 30 Plátano room Chairperson: Liliana Bernardino 18:45H FIB1 Fernandes D, Ribeiro L, Santos S, Carvalho AL. Contactinassociated proteins 1 and 2 (Caspr1 and Caspr2): novel players in the activity-dependent regulation of synaptic AMPA receptors. 18:50H FIB2 Dias RB, Rombo DM, McGarvey J, Henley JM, Sebastião AM. Erythropoietin modulates activity deprivation-induced regulation of synaptic transmission: a role for a hormone in homeostatic plasticity? 18:55H FIB3 Monteiro FA, Monteiro CB, Raposo A, Clavairoly A, Rebelo S, Matos M, Reguenga C, Parras C, Guillemot F, Castro DS. Transcriptional programs regulated by Prrxl1 in developing dorsal root ganglia-dorsal spinal cord nociceptive circuit. 19:00H FIB4 Martins L, Pinto MJ, Coelho MI, Ryu HR, Jeon NL, Almeida RD.. Role of local protein synthesis in presynaptogenesis. 19:05H FIB5 Batalha VL, Hamdane M, Buée L, Blum D, Sadri-Vakili G, Lopes LV. Modulation of Glucocorticoid Receptors by adenosine A2A receptor activation: from gene to protein level. 19:10H FIB6 Conde-Sousa E, Aguiar P. Beyond synaptic plasticity - storing information in the intrinsic excitability properties of neurons. 19:15H FIB7 Tomé A, Silva CG, Fazeli AW, Métin C, Machado NJ, Darmopil S, Launay P, Ghestem A, Nesa M. Caffeine exposure during pregnancy interferes with adenosine A2A receptors affecting hippocampal GABAergic networks in offspring resulting in memory impairment in adulthood. 19:20H FIB8 Correia-de-Sá P, Noronha-Matos JB, Timóteo MA, Ferreirinha F, Marques P, Soares AM, Carvalho C, Cavalcante WLG, Gallacci M. Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals radiochemical and real-time video microscopy studies. 19:25H FIB9 Martins J, Elvas F, Brudzewsky D, Kolomiets B, Picaud S, Cavadas C, Castelo-Branco M, Santiago AR, Ambrósio AF. Neuropeptide Y modulates retinal ganglion cell activity and protects retinal ganglion cell against excitotoxicity. 19:30H FIB10 Rial D, Silva HB., Chen J, Prediger RDS, Cunha RA. The adenosine facilitation of synaptic plasticity in cortico-striatal synapses involves astrocytic A2AR receptors. 19:35H FIB11 Covita J, Rombo D, Dias RB, Sebastião AM, Diógenes MJ. Effect of BDNF on synaptic and extrasynaptic NMDA currents. 19:40H FIB12 Pedro JR, Leitão L, Almeida RD. The role of β-actin mrna translation in axonal outgrowth. 14

15 Neurodegeneration and neuroprotection I May 30 Auditorium Chairperson: Sandra M Cardoso 18:45H FIC1 Dionísio PA, Amaral JD, Lo AC, D Hooge R and Rodrigues CMP. Short-term treatment with TUDCA attenuates the amyloidogenic processing of amyloid precursor protein in APP/PS1 mice. 18:50H FIC2 Silva MF, d Almeida O, Mateus C, Castelo-Branco M. The effect of development and normal aging in cortical/retinal asymmetries: lowlevel evidence for the HAROLD aging model. 18:55H FIC3 Anjo S, Carvalho, Mendes VM, Grãos M, Manadas B. DJ-1 neuroprotection in oxidative stress: insights into Parkinson's Disease pathogenesis. 19:00H FIC4 Pousinha P, Raymond E, Duplan E, Checler F, Marie H. Is APP intracellular domain, AICD, a key player in Alzheimer s disease? 19:05H FIC5 d Almeida OC, Mateus C, Castelo-Branco M. Structural plasticity on visual cortical representations induced by silent visual loss in a subtle ganglion cell degeneration model. 19:10H FIC6 Carvalho C, Santos MS, Oliveira CR, Moreira PI. Mitochondrial dysfunction in diabetes and Alzheimer s disease: the missing link? 19:15H FIC7 Cardoso A, Silva D, Magano S, Pereira PA, Paulo J. Chronic food restriction increases the number of neuropeptide Y-containing neurons in the hippocampal dentate gyrus of aged rats. 19:20H FIC8 Jerónimo-Santos A, Vaz SH, Parreira S, Rapaz-Lérias S, Caetano AP, Buée-Scherrer V, Castrén E, Valente CA, Blum D, Sebastião AM, Diógenes MJ. Amyloid-β peptide dysregulates TrkB receptors and BDNF function by a calpain-dependent mechanism. 19:25H FIC9 Lopes A, Leite-Almeida H, Pinto V, Carlos S, Lopes S, Pinto- Ribeiro F, Silva S, Carvalho A, Clara A, Fernandes R, Almeida A, Sousa S, Sotiropoulos I. Altered nociception by Tau depletion: implication for Alzheimer s disease 19:30H FIC10 Porciúncula LO, Silva CG., Canas PM, Marques JM, Andrade GM, Oses JP, Gachet C, Cunha RA, Rodrigues RJ. P2Y1 receptor is involved in Abeta-induced synaptic and memory loss. 19:35H FIC11 Plácido AI, Oliveira CR, Pereira CMF, Moreira PI. Intracellular accumulation of amyloid beta is associated with ER stress in endothelial cells 19:40H FIC12 Naia L., Rosenstock TR, Oliveira-Sousa SI, Caldeira GL, Laço MN, Hayden MR, Rego AC. Sirtuin modulators alter acetylation and mitochondrial function in in vitro and in vivo Huntington s disease models. 15

16 Fire Sessions II Neural systems I June 1 Bussaco room Chairperson: João Malva 10:00H FIIA1 Simões AP, Kaster M, Machado N, Gonçalves N, Nunes A, Goosens KA, Cunha RA. Role of adenosine A2A receptors in the amygdala: implications for mood disorders. 10:05H FIIA2 Cunha C-S, Coimbra B, Borges S, Rodrigues AJ, Sousa N. Prenatal glucocorticoid exposure disrupts Pavlovian-instrumental transfer: role of D2 dopamine receptor. 10:10H FIIA3 Ribeiro MJ, Inês R. Violante IR, Castelo-Branco M. The electrophysiological signature of response caution. 10:15H FIIA4 Venâncio C, Lobo A, Fernandes S, Magalhães A, Peixoto F, Antunes L, Summavielle T. Chronic low doses of ketamine induce persistent region specific neuronal changes in an adult rat model. 10:20H FIIA5 French CA, Feliciano C, Paixão VB, Jin X, Fisher SE, Costa RM. Dissecting Foxp2 Function in Motor-Skill Learning Circuits. 10:25H FIIA6 Lopes S, Bessa JM, Fernandez P, Castelhano-Carlos M, Morais M, Vieira MJ, Cerqueira JJ, Almeida OFX, Sousa N, Sotiropoulos I. Is depression a neurodegenerative disorder? an in-vivo link between depression, antidepressant action and Alzheimer s disease. 10:30H FIIA7 Machado NJ, Gonçalves N, Souza CM, de Almeida LP, Cunha RA. Adenosine A2A receptors in the amygdala control behavioral modifications in rats subject to repeated restraint stress. 10:35H FIIA8 Santos FJ, Costa RM. Cortical and striatal dynamics during operant motor skill learning. 10:40H FIIA9 Borges S, Coimbra B, Cunha C, Pego JM, Sousa N, Rodrigues AJ. Dopaminergic modulation of affective and social deficits induced by prenatal glucocorticoid exposure. 10:45H FIIA10 Cardoso-Cruz H, Dourado M, Lima D, Galhardo V. Reduced hippocampus-prefrontal cortex connectivity in rats performing a spatial working memory task under neuropathic pain condition. 10:50H FIIA11 Bernardino I, Castelhano J, Farivar R, Castelo-Branco M. Neural correlates of 3D coherent visual perception in Williams syndrome: electrophysiological evidence. 10:55H FIIA12 Ventura-Silva AP, Melo A, Ferreira AC, Carvalho MM, Campos FL, Sousa N, Pêgo JM. Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior. 16

17 Cell signaling II June 1 Plátano room Chairperson: Ana Luísa Carvalho 10:00H FIIB1 Gonçalves FQ, Rial D, Silva HB, Cunha RA. Inhibition of ecto- 5 -nucleotidase activity facilitates short-term and inhibits long-term plasticity in two different mouse brain regions. 10:05H FIIB2 Ferreira J, Rio P, Li KW, Craig AM, Carvalho AL. Changes in the proteome of the postsynaptic densities of cortical neurons from mice lacking the GluN2B subunit of NMDA receptors. 10:10H FIIB3 Lima A, Reis M, Oliveira AF, Sardinha VM, Mota C, Pinto L, Marques F, Cerqueira JJ, Sousa N, Oliveira JF. Glial pathology in the prefrontal cortex affects the cognitive function of the rat. 10:15H FIIB4 Aroeira RI, Sebastião AM, Valente CA. BDNF decreases glycine uptake in brain synaptosomes by reducing GlyT2 membrane insertion. 10:20H FIIB5 Beleza OB, Ferreira S, Alçada-Morais S, Marques JM, Simões AP, Cunha RA, Rodrigues RJ. Purinergic signaling is essential for proper neuronal polarization. 10:25H FIIB6 Gonçalves S, Outeiro TF. Elucidating the effect of alphasynuclein aggregation modulators in vesicular trafficking. 10:30H FIIB7 Matos M, Augusto E, Wei CJ, Schwarzschild MA, Agostinho P, Cunha RA, Chen J-F. Deletion of adenosine A2A receptors from astrocytes alters glutamatergic synapses and triggers enhanced psychomotor responses and memory deficits characteristic of schizophrenia. 10:35H FIIB8 Silva M, Tavares I, Morgado C. Serotonin elicits pronociception in diabetic neuropathic pain through the activation of spinal 5-HT3 receptor. 10:40H FIIB9 Silva HB, Real J, Chen J-F, Cunha RA, Tomé AR. Enhanced density and greater impact of adenosine A2A receptors in the control of cortico-striatal plasticity in pre-symptomatic Huntington s disease R6/2 mice. 10:45H FIIB10 Esteves SL, Fernandes EF, da Cruz e Silva O, Fardilha M. PPP1 a putative Synphilin-1A PhosphoProtein Phosphatase/ Implications for Lewy Bodies formation. 10:50H FIIB11 Augusto E, Matos M, Sévigny J, El-Tayeb A, Müller CE, Chen J-F, Cunha RA. Ecto-5 -nucleotidase (CD73)-mediated formation of ATP-derived adenosine is critical for the striatal adenosine A2A receptor functions. 10:55H FIIB12 Mota SI, Ferreira IL, Ferreiro E, Carvalho AL, Oliveira CR, Rego AC. Altered NMDA receptor and Src related signaling in Alzheimer s disease. 17

18 Neurodegeneration and neuroprotection II June 1 Auditorium Chairperson: Cláudia MF Pereira 10:00H FIIC1 Lemos C, Gutierres J, Silva H, Agostinho P, Oliveira CR, Carvalho RA, Cunha RA. Intracerebroventricular streptozotocin induces cognitive and metabolic dysfuntion accompanied by synaptic modifications. 10:05H FIIC2 Silva R, Henriques AG, Oliveira JM, Carvalho L, Rosa I, Delgadillo I, Cruz e Silva OAB., Nunes A. Identification of Alzheimer biomarkers with mid-infrared spectroscopy exploratory study. 10:10H FIIC3 Carmo MRS, Canas PM, Menezes APF, Nunes ACL, Queiroz F, Rolo AP, Palmeira CM, Cunha RA, Andrade GM. Impact of a p2x7 (atp) receptor antagonist on 6-ohda-induced neurotoxicity in vivo and in vitro. 10:15H FIIC4 Nascimento-Ferreira I, Nóbrega C, Vasconcelos-Ferreira A, Onofre I, Albuquerque D, Aveleira C, Déglon N, Almeida L. Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. 10:20H FIIC5 Naffah-Mazzacoratti MG, Simões PSR, Visniauskas B, Yacubian EMT, Centeno R, Canzian M, Lopes-Cendes I, Morelli CVM, Cavalheiro EA, Chagas JR. Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus in subjects with temporal lobe epilepsy (TLE). 10:25H FIIC6 Canas PM, da Silva BS, Cunha RA. Up-regulation of A2AR density in postmortem prefrontal tissue of individuals who committed suicide. 10:30H FIIC7 Rego AC, Mota SI, Costa RO, Caldeira GL, Santana I, Padovano C, Fonseca AC, Cunha C, Letra L, Oliveira CR, Ferreira IL, Pereira CMF. Oxidative and ER stress in early stages of Alzheimer s disease. 10:35H FIIC8 Cardoso S, Santos MS, Moreira PI. Brain insulin signaling pathway and synaptic integrity under insulin-induced recurrent hypoglycemia and long-term hyperglycemia. 10:40H FIIC9 Martins T, Elvas F, Galvão J, Ambrósio AF, Santiago AR. Activation of adenosine A3 receptor protects retinal ganglion cells from ischemia-reperfusion injury. 10:45H FIIC10 Simões AT, Gonçalves N, Nobre RJ, Duarte CB, de Almeida LP. Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease. 10:50H FIIC11 Amorim RP, Araújo MGL, Canzian M, Ariza CB, Porcionatto M, Cavalheiro EA, Ulrich H, Carrete Jr.H, Centeno RS, Yacubian EM, Fernandes MJS. Expression of purinergic receptors as phenotypic changes in human temporal lobe epilepsy. 10:55H FIIC12 Perfeito R, Ribeiro M, Stefanis L, Cristina Rego AC. Alphasynuclein overexpression modifies the antioxidant response in SH- SY5Y neuroblastoma cells. 18

19 Fire Sessions III Neural systems II June 1 Bussaco room Chairperson: António Francisco Ambrósio 11:30H FIIIA1 Gonçalves N, Machado NJ, Souza CM, de Almeida LP, Cunha RA. Impact of ventro-medial striatal adenosine A2A receptors on moodand anxiety-related behavioural modifications in rats subjected to repeated restraint stress. 11:35H FIIIA2 Quiñones-Correa MJ; Villegas EM, Álvarez-Otero R. Calciumbinding proteins in the brain and retina of a teleost fish. 11:40H FIIIA3 Rodrigues AJ, Bessa C, Marques F, Vasconcelos B, Pereira F, Miranda A, Maciel P. GABAergic and cholinergic circuit defects in a C. elegans mutant of an intellectual disability-associated gene. 11:45H FIIIA4 Duarte J, Raimundo M, Castelo-Branco M. Cortical responses during parametric visual speed discrimination in healthy and diabetic patients. 11:50H FIIIA5 Martins GJ, Vaz A, Costa RM. Motor and instrumental learning in mice with interneuron NMDA receptor deletion. 11:55H FIIIA6 Coimbra B, Soares-Cunha C, Borges S, Sousa N, Rodrigues AJ. From novelty-seeking to impulsive behaviour: effects of prenatal exposure to glucocorticoids. 12:00H FIIIA7 Rodrigues AP, Rebola J, Jorge H, Moreno J, Pereira M, Festas I, Castelo-Branco M, van Asselen M. Noise exclusion processing is impaired in developmental dyslexia: an eye movement study. 12:05H FIIIA8 Real JI,Gonçalves N, Cunha RA. Adenosine A2A receptors control the modification caused by repeated restraint stress of synaptic plasticity in the pre frontal cortex from rat brain slices. 12:10H FIIIA9 Novais A, Ferreira C, Marques F, Campos F, Palha J, Sousa N, Dalla C, Kokras N, Sousa JC. Neudesin abblation induces an anxiety-like phenotype. 12:15H FIIIA10 da Silva JA, Tecuapetla F, Paixão V, Costa RM. Exploring the role of SNC dopaminergic neurons in the initiation of self paced actions. 12:20H FIIIA11 Simões M, Amaral C, Carvalho P, Castelo-Branco M. ERP responses to morphed facial expressions in virtual reality environments. 12:25H FIIIA12 Pinto V, Costa J, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Chronic stress has different outcomes in the structure and function of the dorsal and ventral hippocampus. 19

20 Neuroinflammation June 1 Plátano room Chairperson: Ana Paula Silva 11:30H FIIIB1 Cristóvão G, Pinto MJ, Gomes CV, de Almeida R, Cunha RA. Neuron-microglia interactions in the developing CNS: focus on the role of microglia before synapse formation. 11:35H FIIIB2 Caldeira C, Frederico A, Oliveira AF, Lidónio G, Vaz A, Fernandes A, Brites D. Cell ageing effects on microglia response to Aβ. 11:40H FIIIB3 Monteiro S, Ferreira F, Pinto V, Roque S, Calçada D, Correia- Neves M, Cerqueira JJ. Absence of IFN-γ leads to an enhanced cognitive phenotype. 11:45H FIIIB4 Vaz AR, Barbosa M, Ferreira A, Cunha C, Brites D. Exploring anti-inflammatory strategies on motor neuron degeneration in ALS. 11:50H FIIIB5 Mesquita SD, Falcão AM, Ferreira AC, Sousa JC, Sousa N, Marques F, Palha JA. Lipocalin 2 is produced in response to amyloid beta. 11:55H FIIIB6 Saraiva T, Rocha S, Esteves M, Cristóvão AC, Baltazar G, Alves G, Bernardino L. Histamine modulates dopaminergic neuronal survival by boosting microglial activity. 12:00H FIIIB7 Elvas F, Madeira M, Martins T, Santiago AR, Cavadas C, Ambrósio AF. Neuropeptide Y receptor Y1 modulates microglia activation in the rat retina. 12:05H FIIIB8 Cristóvão G, Viegas M, Vieira O, Cunha RA, Gomes CV. Microglia phagocytic ability is preserved irregardless changes in ATP levels and depends upon adenosine A2AR tonic activation. 12:10H FIIIB9 Cunha C, Vaz AR, Brites D. Motor neuron signaling to microglia: a clue for ALS pathogenesis. 12:15H FIIIB10 Madeira MH, Elvas F, Ambrósio AF, Santiago AR. Adenosine A2A receptor modulates LPS-induced neuroinflammation in the retina. 12:20H FIIIB11 Martins I, Carvalho P, Westerink BH, Wilson SP, Tavares I. GABA enhances pain facilitation from the brain during inflammatory pain. 12:25H FIIIB12 Miranda C, Santos NC, Sousa N, Correia-Neves M, Roque S. Can distinct cognitive performances among aged individuals be related with distinct immune system profiles? 20

21 Neurodegeneration and neuroprotection III June 1 Auditorium Chairperson: Paula Moreira 11:30H FIIIC1 Esteves M, Saraiva T, Rocha S, Baltazar G, Ferreira L, Bernardino L. Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model of Parkinson s disease. 11:35H FIIIC2 Vieira M, Fernandes J, Carreto L, Santos M, Duarte CB, Carvalho AL, Santos AE. Necroptotic neuronal death of hippocampal neurons submitted to an ischemic stimulus. 11:40H FIIIC3 Brudzewsky D, Elvas F, Martins J, Santiago AR, Woldbye DPD, Ambrósio AF. Retinal ganglion cells express neuropeptide y and npy receptors. 11:45H FIIIC4 Morgado C, Silva M, Amorim D, Almeida A, Pinto-Ribeiro F, Tavares I. Diabetes alters the activity of rostroventromedial medulla (RVM) ON-like and OFF-like cells: a role in diabetic neuropathic pain? 11:50H FIIIC5 Silva DF, Esteves AR, Cardoso SM. Mitochondrial dysfunctiondependent microtubule depolarization drives autophagic-lysosomal pathway impairment in MCI and AD cybrids. 11:55H FIIIC6 Ciaccioli G, Martins A, Rodrigues C, Vieira H, Calado P. A Powerful Yeast Model to Investigate the Synergistic Interaction of a- Synuclein and Tau in Neurodegeneration. 12:00H FIIIC7 Esteves AR, Cardoso SM. LRRK2 as a player on mitochondrial and microtubule dynamics impairment in sporadic Parkinson s disease. 12:05H FIIIC8 Gomes E, Samy S, Carvalho MM, Teixeira FG, Leite-Almeida H, Reis RL, Sousa N, Silva NA, Salgado AJ. Functional Gellan Gum Hydrogels and Cell based Therapies A Novel Therapeutic Approach for Spinal Cord Injury Regeneration. 12:10H FIIIC9 Ferreira DG, Coelho JE, Batalha VL, Albino-Teixeira A, Outeiro TZ, Lopes LV. A2AR blockade prevents ltp impairment induced by alpha-synuclein. 12:15H FIIIC10 Fernandes J, Vieira M, Carreto L, Santos M, Duarte CB, Carvalho AL, Santos AE. In vitro ischemia in hippocampal neurons triggers a transcriptional response to down-regulate synaptic proteins. 12:20H FIIIC11 Oliveira AM; Cardoso SM; Ribeiro M; Seixas RSGR, Silva AMS; Rego AC. Luteolin and 3-alkyl-luteolin derivatives: potential neuroprotective agents in Huntington s disease striatal cells. 12:25H FIIIC12 Candeias E, Duarte AI, Carvalho C, Correia S, Fernandes MA, Seiça R, Santos MS, Oliveira CR, Moreira PI. Adult female rat brain is less prone to Alzheimer disease hallmarks than male brain: the role of insulin/igf-1 signaling. 21

22 Posters Cruzeiro room Neurodegeneration and neuroprotection P1. Pereira PA, Vilela M, Sousa A, Cardoso A, Madeira MD. Effects of Chronic Ethanol Treatment and Withdrawal on the Neuropeptide Y Content and Cholinergic Innervation of the Rat Cerebral Cortex. P2. Pinheiro S, Silva J, Pinto V, Sousa N, Sotiropoulos I. Structural dynamics of synapse: the role of TAU and its vulnerability to stress hormones. P3. Bessa C, Pereira F, Vasconcelos B, Marques F, Miranda A, Maciel P*, Rodrigues AJ*. Neurobehavioral deficits in C. elegans mutants of neurodevelopmental disorders. P4. Correia SC, Santos MS, Moreira PI. Mitoplasticity during hypoxic preconditioning: the brain battles to survive! P5. Tak H, Durán R, Alfonso M, Faro LRF. Effects of the cholinesterase inhibitors galantamine and tacrine on in vivo release of dopamine from rat striatum. P6. Lopes JP, Rial D, Canas PM, Rodrigo A. Cunha RA. The β-amyloid (1-42) peptide-induced impairment of hippocampal LTP is eliminated in adenosine A2A receptor knock-out mice. P7. Naia L, Ferreira IL, Cunha-Oliveira T, Ribeiro M, Duarte AI, Ribeiro MJ, Oliveira CR, Saudou F, Humbert S, Cristina Rego A. Activation of IR,IGF-1R signaling pathways promote mitochondrial function and energy metabolism in Huntington s disease human lymphoblasts. P8. Caetano AP, Jerónimo-Santos A, Vicente H, Outeiro TF, Sebastião AM, Diógenes MJ. Unravelling the effect of different Abeta species on BDNF effects upon hippocampal synaptic plasticity. P9. da Silva AC, Jones J, Rego AC, Cunha RA. Circadian oscillation of memory performance, hippocampal long-term potentiation and cortical mitochondrial function in a mouse model of Alzheimer s disease. P10. Júlio F, Caetano G, Januário C, Castelo-Branco M. Neuropsychological and Saccadic Measures in Premanifest and Manifest Huntington s Disease. P11. Sousa RM, Carvalho LS, Morais M, Pinho D, Tavares I, Albino-Teixeira A. Spinal redox status in peripheral neuropathic pain. P12. Mota C, Neves S, Martins S, Sousa JC, Sousa N, Cerqueira JJ. Heterogeneity in cognitive aging: looking for structural correlates. P13. Martins-Araujo M, Teixeira-Castro A, Jalles A, Santos L, Maciel P. Establishing a fast-throughput system for the identification of therapeutic compounds in a C. elegans model of Machado-Josep disease (MJD). 22