Curriculum vitae. THALMANN George Niklaus May 11, 1959 October 2010

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1 Curriculum vitae THALMANN George Niklaus May 11, 1959 October 2010 Nationality: Marital status: Languages: Address: Swiss Married, 3 children English, German, French, Italian Department of Urology Anna-Seiler-Haus Inselspital CH-3010 BERN tel. (031) fax. (031) Fuchshalden 7 CH-3033 Wohlen b. Bern tel. (031) Education 1964/65 Primary School St. Ignatius of Loyola, New York City Schools in Bern, Switzerland Graduation and immatriculation at the Medical School of the University of Bern, Switzerland Medical School of the University of Bern, Switzerland. Diplomas 1978 Matura Typ B 1984 Graduation from the Medical School of the University of Bern, Switzerland Medical Doctors Degree from the Medical School, University of Bern: Thesis: The electrodermal orientation reaction to auditive stimuli with and without signal character in children with minimal cerebral dysfunction in comparison to a healthy control group Swiss Board (FMH) of Urology 1997 Fellow of the European Board of Urology 2000 Venia docendi for Urology (Associate Professor), University of Bern, Switzerland Titularprofessur (Professor of Urology), University of Bern, Switzerland Postgraduate Education 1985/86 Resident at the Policlinic for Child Psychiatry, University of Bern, Switzerland (Prof. W. Züblin) Replacement of a general practitioner in Göschenen, Switzerland. 1986/87 Swiss Army Medical Officer in Thun and Moudon. 1987/88 Surgical resident Cantonal Hospital Obwalden, Switzerland ( Dr. C. Müller). 1989/90 Surgical resident and chief resident Regional Hospital Thun, Switzerland (Dr. C. Ghielmetti and Dr. H.P. Müller) Resident at the Department of Urology, University of Bern, Switzerland (Prof. E.J. Zingg).

2 Postdoctoral research fellowship Urology Research Laboratory (Prof. Leland W. K. Chung, Ph.D.), Department of Urology (Prof. Andrew C. von Eschenbach, M.D.) The University of Texas M. D. Anderson Cancer Center, Houston, Texas 1995 Resident at the Department of Urology, University of Bern, Switzerland (Chairman and Director: Prof. U.E. Studer) 1996 Oberarzt (Assistant Professor) Department of Urology, University of Bern, Switzerland (Chairman and Director: Prof. U.E. Studer) Oberarzt I (Senior staff, Assistant Professor) Department of Urology, University of Bern, Switzerland (Chairman and Director: Prof. U.E. Studer) Leitender Arzt (Permanent staff, Associate Professor) Department of Urology, University of Bern, Switzerland (Chairman and Director: Prof. U.E. Studer) 2004 Stellvertretender Chefarzt (Vice-chairman, Associate Professor) Department of Urology, University of Bern, Switzerland (Chairman and Director: Prof. U.E. Studer) Chefarzt ad personam (Professor, designated chairman), Department of Urology, University of Bern, Switzerland 2010 Ordinarius für Urologie (Professor and Chairman), Department of Urology, University of Bern, Switzerland

3 Awards/Honors 1994 Travel Award of the European Society for Urologic Oncology and Endocrinology Meeting in Bern, Switzerland Travel Award of the Joint Meeting of the Society for Basic Urologic Research and the European Society for Urologic Oncology and Endocrinology Meeting in Rotterdam, The Netherlands First Prize in the Laboratory Research Category of the American Urological Association Prize Essay Contest: "Androgen-independent and osseous metastatic progression of human prostate cancer: Model development and roles of osteopontin." 1997 Travel Award of the European Society for Urologic Oncology and Endocrinology, Joint meeting SBUR/ESUOE 1997, Pacific Grove, CA, USA CaPCURE Research Award: Targeting Prostate Cancer Bone Metastasis By Mimotopes in the amount of $ 1999 European Association of Urology (EAU) Matula Award for young urological academicians in the amount of 10'000.- Euro 1999 Theodor-Kocher Award of the University of Berne, Switzerland, in the amount of 50'000.- sfr 2002 Award of the Association pour la Recherche sur les Tumeurs de la Prostate (ARTP), European Society for Urological Research (ESUR), Trento, Italy 2003 First Poster Prize of the Swiss Urological Association President of the European Society for Urological Research Board member of the European Society for Urological Research Member of the Scientific Office of the European Association of Urology Board member Bernese Cancer League 2008 Pfizer-Research Prize (C.A. Rentsch et al., Am. J. Pathol. 2007) 2008 Poster Prize American Urological Association Board member European Society for Urological Oncology Member of the National Research Council of the Swiss National Science Foundation (Forschungsrat Abteilung III und Fachausschuss Interdisziplinär) 2009 Prize for the second best abstract of the European Association of Urology (EAU) 2010 Prize for the best abstract of the European Association of Urology (EAU) 2010 Best reviewer award of the Journal of Urology 2010 Reviewer of the Month European Urology

4 Grants 1993 Supportive grant Dr. Arnold U. und Susanne Huggenberger-Bischoff Stiftung zur Krebsforschung Supportive grant Swiss National Foundation 1995 Research grant Swiss National Foundation # (3 years) Title: Osteopontin: (OPN): A mediator of prostate cancer progression and potential therapeutic target sfr SmithKline Beecham European Urological Scholarship To: Dr. Ö. Adsan, Ankara, Turkey. Project: Molecular staging of prostate cancer with the use of reversed transscription polymerase chain reaction Euro. Institute: Univeristy of Berne, Switzerland. Dr. G.N. Thalmann 1996 Research grant Krebsforschung Schweiz (Swiss Cancer Research Foundation) Title: Molecular staging of prostate cancer with the use of the polymerase chain reaction sfr 1997 Research grant Bernische Krebsliga (Bernese Anticancer League) Title: Molecular staging of prostate cancer with the use of the polymerase chain reaction Research grant Swiss National Foundation # (Prolongation 6 months) Title: Osteopontin: (OPN): A mediator of prostate cancer progression and potential therapeutic target Research grant Niels und Desirée Yde Stiftung. Title: Targeting renal cell carcinoma by mimotopes. 75'000.- sfr 1999 Research grant Swiss National Foundation # Title: Markers and gene regulation of prostate cancer progression. 235'000.- sfr 1999 NFP-37 Project /1: Targeting the tumor vasculature with mimotopes. Prolongation for 2 years (co-investigator) sfr 1999 Stiftung zur Förderung der wissenschaftlichen Forschung an der Universität Bern. 15'000.- sfr Josephine Clark-Fonds für Forschung auf dem Gebiet der Medizin sfr 2001 Novartis-Stiftung 01B32: Identification of molecular mechanisms underlying prostate cancer progression and metastasis sfr (co-investigator) 2002 Research grant Swiss National Foundation # Title: Osteomimetic peptides in prostate cancer progression and metastasis sfr. 296'000.- sfr 2002 Research grant Bernische Krebsliga: From Bench to Bedside Prevention, Detection and Treatment of Micrometastases (Principal Investigator), sfr 2003 EC 6 th Framework 1.1- HEALTH: PRIMA: integral management approach. Contracts under negotiation (group leader) EC 6 th Framework 1.1- HEALTH: EMIL: European molecular imaging laboratories. Contracts under negotiation. (Co-applicant group leader) 2004 Research grant Bernische Krebsliga: From Bench to Bedside Prevention, Detection and Treatment of Micrometastases (Principal Investigator), sfr (Continuation) 2005 EC 6 th Framework LIFESCIHEALTH-5: PROMET: molecular-oriented detection and treatment of minimal residual disease. Contracts under negotiation (Primary investigator), CANCURE project funded by the European Commission Marie Curie actions (group leader) 2005 Oncosuisse Research grant OCS : Impact of therapeutic and preventive strategies in prostate cancer on prostate-specific antigen (PSA), gene expression and tumor cell survival 2006 Prolongation Research grant Swiss National Foundation # Title: Osteomimetic peptides in prostate cancer progression and metastasis

5 2007 Research grant Swiss National Foundation # 3100A / 1. Title: The role of stroma in prostate cancer development and progression. 250'877.- sfr 2009 PRO-NEST Marie Curie Action "Initial Training Networks" (ITN). FP7- PEOPLE-ITN-2008 (group leader). Funding A, under negotiation 2009 Research grant Swiss National Foundation # SNF 31003A_ Title: Locoregional treatment of prostate cancer metastase to bone using implant-mediated hyperthermia sfr (Co-applicant) 2010 Research grant Swiss National Foundation # SNF _ Title: Detection and Targeting of Lymph Node Metastases in Prostate Cancer sfr (Prinicipal investigator)

6 Clinical Research Protocols EORTC Protocol 30071: Double blind randomized Phase II Trial in patients with advanced urothelial tract cancer (T3b, T4/N+/M+) of Gemcitabine and Cisplatin with Sorafenib or Placebo (Co-Chairman) Schweizerisches Institut für angewandte Krebsforschung: A prospective randomized study for the comparison of two BCG strains (Bacille Calmette-Guèrin) in the prophylaxis of papillary tumors stage Ta and T1 and the treatment of carcinoma in situ Principle investigator. Closed. Prospective, randomized, open-label pilot study for the clinical evaluation of intravesical iscador instillation in superficial tumours of the urinary bladder.( Co-investigator in collaboration with the Kollegiale Instanz für Komplementärmedizin KIKOM and the Arlesheim Klinik for anthroposophical medicine ). Closed. Memberships European Organisation for the Research and Treatment of Cancer (EORTC) and Secretary of the Superficial Bladder Cancer Disease Oriented Group European School of Urology (Staff) American Urological Association (Corresponding member) European Society for Urological Research (board member) European Society for Oncological Urology (board member) Association of Academic European Urologists (full member) European Urological Association (full member) Society for Basic Urological Research (member) American Association for Cancer Research (member) Urological Research Society (member) American Society for Gene Therapy (member) Swiss Urological Association (member) Swiss Society for Oncology (member) Schweizerische Gesellschaft für Ultraschall in Medizin und Biologie

7 Editorial Boards British Journal of Urology International Journal of Urology International Editorial Committee Der Urologe Annals of Urology Reviewer Journal of Urology European Urology British Journal of Urology The Prostate Der Urologe A Urology Nature Clinical Practice Urology American Journal of Epidemiology Clinical Cancer Research Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics International Journal of Cancer Carcinogenesis Annals of Human Genetics Biomed Central Cancer The ScientificworldJOURNAL Gynecologic Oncology Critical Reviews in Hematology/Oncology Swiss Medical Weekly Infomed Asian Journal of Andrology British Journal of Cancer Frontiers in Bioscience World Journal of Urology International Journal of Surgery Expert Reviews in Molecular Medicine Free Radical Biology & Medecine Journal of Zhejiang University Science B Cancer Treatment Reviews Pathobiology International Urology and Nephrology Human Pathology Prostate Cancer and Prostatic Diseases Prostate and bladder cancer Urological oncology Urological oncology Urological oncology Bladder cancer Bladder cancer Prostate and bladder cancer Urology Urology Oncology Bladder cancer Bladder and prostate cancer Bladder cancer Urological oncology Bladder cancer European Association of Urology 1998 Meeting Barcelona (basic research prostate cancer) European Association of Urology 1999 Meeting Stockholm (basic research prostate cancer) European Association of Urology 2000 Meeting Brussels (basic research prostate cancer) European Association of Urology 2001 Meeting Geneva (basic research prostate cancer) European Association of Urology 2002 Meeting Birmingham (basic research prostate cancer) European Association of Urology 2003 Meeting Madrid (basic research prostate cancer) European Association of Urology 2004 Meeting Istanbul (basic research prostate cancer) Deutsche Gesellschaft für Urologie, Annual Meeting 2002 (Bladder cancer; basic and clinical research)

8 Deutsche Gesellschaft für Urologie, Annual Meeting 2003 (imaging techniques) Deutsche Gesellschaft für Urologie, Annual Meeting 2004 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2005 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2006 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2007 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2008 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2009 (prostate cancer basic research) Deutsche Gesellschaft für Urologie, Annual Meeting 2010 (prostate cancer basic research)

9 Expert Opinion Member of the Scientific Committee of the European Urological Association. Member Editorial Board British Journal of Urology Section Investigative Urology Gene Therapy Working Group, Interdisziplinäre Schweizerische Kommission für Biologische Sicherheit in Forschung und Technik, Bundesamt für Umwelt, Wald und Landschaft, Bern, Switzerland European Organisation for Research and Treatment of Cancer (EORTC) for the Protocol Review Committee (Genito-Urinary Cancers) Interkantonale Kontrollstelle für Medikamente der Schweiz (1999) MD-PhD Thesis Jury T. Tawadros, University of Lausanne, Switzerland, May 2002 Swiss National Science Foundation (Grant review) Association for International Cancer Research (Grant review) Associazione Italiana per la Ricerca sul Cancro (Grant review) Jubiläumsfonds der Österreichischen Nationalbank (Grant review) Oncosuisse (Grant review) Schweizerische Krebsliga (Grant review) AKF-Programm der Universität Tübingen (Grant review) Dutch Cancer Society (grant review) Deutsche Krebshilfe (Grant review) MA 40 Med.-Wissenschaftl. Fond d. BM Österreich (Grant review) The Cancer Research Society, Ottowa, Ontario, Canada (Grant review) Fondation pour la Recherche Medicale, France (Grant review) The Prostate Cancer Charity research, UK (Grant review)

10 Organisation of Meetings meeting of the Swiss Cancer League, Swiss Urological Society, Swiss Medical Association, Interlaken, 14. September Member of the organizing committee of the 2 nd International Conference on Prostate Cancer Research, University of Iowa, Iowa City, October 12-15, 2002 Urologie Arena, Treatment of advanced renal cell carcinoma, Bern, November 28, Scientific committee, Annual Meeting of the European Society for Urological Research in Athens, November 4 6, 2004 Urologie Arena, Treatment of testicular cancer, Lucerne, November 19, Urologie Arena, Diseases of the penis, Priapism, Bern, November 25, th Meeting of the European Society for Urological Research (ESUR), Malmö, Sweden, September Fortbildung in Allgemeinmedizin Urologie. CME accredited education for general practitioners. Bern, February 1, Fortbildung in Allgemeinmedizin Urologie. CME accredited education for general practitioners. Bern, January 24, SAMO Interdisciplinary Workshop on Urogenital Tumors, Lucerne January 9-10, 2009 Fortbildung in Allgemeinmedizin Urologie. CME accredited education for general practitioners. Bern, January 29, Fortbildung in Allgemeinmedizin Urologie. CME accredited education for general practitioners. Bern, March 4, 2010.

11 Chairs The Second World Congress on Urological Research 1997 (joint meeting of the Society for Basic Urologic Research and the European Society for Urological Oncology and Endocrinology) Interventional Biology Session (December 13th) The Royal Society of Medicine Section of Urology Winter Meeting 1999, Adelboden, Switzerland, Kidney Cancer Session The European Association of Urology XIVth Congress 1999, Stockholm, April 7-11, Poster session: : Molecular Genetics. Swiss Urological Society Annual Meeting 1999, Freiburg, September 2-4, Free communications. The European Association of Urology XVth Congress 2000, Brussels, Belgium April 13-15, Poster session: : Basic research. European School of Urology Black Sea Meeting, Odessa, 2-3 November 2001, Stone Session. 16 th Congress of the European Society for Urological Research, Basic Research in Prostate Cancer Session, Trento, Italy, October 24-26, nd International Conference on Prostate Cancer Research, Epidemiology, Prevention and Control. University of Iowa, Iowa City, October 12-15, 2002 The European Association of Urology XVIIth Congress 2002, Birmingham, Great Britain, February 23-26, oral session: Urological Imaging. Urologie Arena, Treatment of advanced renal cell carcinoma, Bern, November 28, th World Congress on Urological Research, Imaging in Urology Session, London, Great Britain, September 24-27, The European Association of Urology XVIIIth Congress 2003, Madrid, Spain, March 12-15, Poster session: Prostate Cancer: Molecular Tumour Profiling. basic research: androgen receptor/apoptosis. 19 th Congress of the European Association of Urology, Vienna, March 24 27, Urologie Arena, Treatment of testicular cancer, Lucerne, November 19, Gene therapy: the future of tumour therapy or dead end? European Society for Urological Research (ESUR) Section meeting March 16, 2005 The European Association of Urology XXth Congress 2005, Istanbul, Turkey, March 17-19, Poster session: Prostate Cancer: Tumour cell biology target discovery. The European Association of Urology XXth Congress 2005, Istanbul, Turkey, March 17-19, Debate: Is preservation of the prostate at radical cystectomy an appropriate option?. Prostatakarzinom Freie Mitteilungen. Schweizerische Gesellschaft für Urologie. Geneva, September 8-10, 2005.

12 German Urological Association 57 th Congress, Düsseldorf, Germany, September 21-24, 2005 Prostatakarzinom Therapie lokalisierter Tumoren I Urologie Arena, Diseases of the penis, Priapism, Bern, November 25, th Engadin Prostate Cancer Winter Symposium, Zuoz, March 15-19, 2006 session 9 European Society for Urological Research Section meeting, Paris, April 5 th, omics in Urological diseases The European Association of Urology XXI Congress 2006, Paris, France, April 5-8 Oral session: Bladder Cancer: Urothelial tumors: Management of infiltrative/advanced tumours I. The European Association of Urology XXI Congress 2006, Paris, France, April 5-8 Subplenary Session 7. The European Association of Urology XXI Congress 2006, Paris, France, April 5-8 Oral session: Bladder Cancer: Urothelial tumors: Management of infiltrative/advanced tumours II. The European Association of Urology XXI Congress 2006, Paris, France, April 5-8 European School of Urology Course: Management of infiltrative/advanced urothelial cancer. Forschung Freie Mitteilungen. Schweizerische Gesellschaft für Urologie. Geneva, September 7-9, Keynote lecture Prof. M. Rubin, Boston, US. 17 th Meeting of the European Society for Urological Research (ESUR), Malmö, Sweden, September Epidemiology of Urological Cancers. 17 th Meeting of the European Society for Urological Research (ESUR), Malmö, Sweden, September German Urological Association 58 th Congress, Hamburg, Germany, September 20-23, 2006 Postersitzung: Prostatakarzinom Therapie lokalisierter Tumoren II The European Association of Urology XXII Congress 2007, Berlin, Germany, March Subplenary Session 6. The European Association of Urology XXII Congress 2007, Berlin, Germany, March European School of Urology Course: Management of infiltrative/advanced urothelial cancer. Swiss Society of Urology. Basel, September 27-29, Neues aus der Forschung. Session de la prostate et du rein. 2 nd Rencontres Pratiques en Uro-oncologie d Alsace- Lorraine. December 1-2, 2007 Joint Winter meeting of the Department of Urology, University of Bern and The Royal Society of Medicine Section of Urology, Zermatt January 26 February 1, Switzerland, Prostate Cancer Session. Swiss Society of Urology. Davos, Switzerland. September 4-6, Chirurgische Techniken.

13 Swiss Society of Urology. Lausanne, Switzerland. September 3-5, Prostatakarzinom, Diagnostik und Forschung. Management of Advanced Prostate Cancer. The 6th Engadin Prostate Cancer Winter Symposium, Zuoz, Switzerland March 2010 The European Association of Urology XXV Congress 2010, Barcelona, Spain, April Plenary Session 2; : From prevention to risk calculation The European Association of Urology XXV Congress 2010, Barcelona, Spain, April Moderation Poster Session 54: Prognostic biomarkers The European Association of Urology XXV Congress 2010, Barcelona, Spain, April Moderation EAU Section Meetings; Superficial TCC: New chemotherapeutics in sight Swiss Society of Urology. Lausanne, Switzerland. September 1-3, Moderation Poster Session 2: Experimentelles Forum German Urological Association 62 nd Congress 2010, Düsseldorf, Germany, September Moderation Forum F1: Kontroversen beim Blasenkarzinom German Urological Association 62 nd Congress 2010, Düsseldorf, Germany, September Moderation V17: Urothelkarzinom Therapie German Urological Association 62 nd Congress 2010, Düsseldorf, Germany, September Plenum II: Kontroversen in der Urologie: Zystektomie offen vs. Laparoskopisch vs. robotic

14 Invited Talks Screening in In whom and how? International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010 Localized prostate cancer in a young patient: oncological, functional and QOL issues. Which is the best option? Open radical prostatectomy International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010 Extended pelvic lymphadenectomy: a new standard? International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010 Biochemical recurrences after treatment with curative intention: What to do? When? Clinical cases International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010 Conservative management in high risk tumors: When to move along? International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010 Non-muscle invasive bladder cancer: difficult cases International Symposium Update in Uro-Oncology 2010, MD Anderson Cancer Senter, Santiago, July 8-9, 2010

15 Postgraduate Courses 1988 Basic Course Osteosynthesis, Davos, Switzerland 1989 Basic Course Gastroenterologic Surgery, Davos, Switzerland 1990 Small Fragmentary Osteosynthesis Course, Waldenburg, Switzerland 1991/92 Medical Statistics Course, Berne, Switzerland 1992 Basic Course Laparoscopic Surgery, Berne, Switzerland 1995 Urologic Laparoscopic Surgery Course, American Urological Association, Houston, Texas, USA 1996 Technique of Scientific Presentations 1996 Management Course, Interlaken, Switzerland 1999 Organisation of the operating theatre 2009 Strahlenschutz für Ärzte, Paul Scherrer Institute

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