CURRICULUM VITAE 2012, March

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1 CURRICULUM VITAE 2012, March OVERVIEW INFORMATION Name: MARHOUM EL FILALI Kamal Date and birthplace: July 16, 1958 in Casablanca, Sex: Male Nationality: Moroccan Contact Information: Business contact Personal details Address: Faculté de Médecine Address: Résidence Mawlid 3, Appt C54 19, Rue Tarik Bnou Ziad Rue Abou Taour Casablanca, Casablanca, Tel: Tel: Fax: mefkamal@gmail.com mefkamal@hotmail.com Areas of expertise: - Clinical experience in infectious diseases, particularly in care of HIV infected patients - Quantification of antiretroviral drugs needs for HIV infected patients in - HIV/AIDS prevention campaigns - Evaluation of projects related to HIV/AIDS - Education and training in the field of infectious diseases and HIV infection Expertise related to HIV/AIDS - In : Collaboration with the National AIDS Program Commitment in the Moroccan experience of access to care and to antiretroviral therapy Involvement in many national campaigns of prevention In charge of HIV infection course in the Faculty of Medicine and Pharmacy of Casablanca - At the international level : Collaboration as consultant with UNAIDS (Republic of Congo in 2001) Contribution to the development of an african consensus on antiretroviral therapy ( Dakar, October 2000 ) Collaboration as consultant with WHO-EMRO (Republic of Yemen in 2007) Collaboration as consultant with WHO-EMRO (Republic of Syria in 2009) Currently preparing a basic training on HIV infection in collaboration with WHO-EMRO

2 EDUCATION 1993 Certificate in Infected Patient Resuscitation Xavier Bichat University Paris, France 1993 Certificate in AIDS and retroviral diseases Xavier Bichat University, Paris, France 1993 Certificate Résident Etranger du Collège de Médecine des Hôpitaux de Paris 1989 Maghreban Certificate in Health Sciences Pedagogy Collège de Médecine des Hôpitaux de Paris, France Medical School, Casablanca, 1985 MD Medical School, Casablanca, Medical School, Casablanca, 1976 Baccalaureate University of Bordeaux, France Lycée Lyautey, Casablanca, TRAINING 2010, October Antifungal preceptorship meeting. University of South Manchester, UK 2008, February Human Participants Protection Education for Research Teams NIH, online course 2007, June Advanced Course on Security WHO, online course 2006, October GCP Training for investigators Roche, Casablanca, 2006, April Course on applied regression modelling University of Bristol and University of Bern, Cape Town, South Africa 2005, July Course : Managing Procurement and Logistics of HIV/AIDS Drugs and Related Supplies World Bank Institute, Beirut, Lebanon 2002, July Training : Clinical studies monitoring Georges Pompidou European Hospital, Paris, France 2001, March Atelier de mise à niveau des consultants francophones UNAIDS / WHO, Rabat, 2000, June The 2 nd african workshop on antiretrovirals Dakar, Senegal 1999, July The first African Workshop on Antiretrovirals Dakar, Senegal

3 1997, May Symposium on HIV infection Mediterranean Society of Infectious and Parasitic Diseases, Cairo, Egypt 1996, March Course on Research Methodology Medical School, Casablanca, 1995, April Course on biostatistics Medical School, Casablanca, Training : Intensive care Bichat-Claude Bernard Hospital, Paris, France 1992, June Training : Digestive endoscopia Beaujon Hospital, Paris, France 1990, January Training : HIV infection care practice Bichat-Claude Bernard Hospital Paris, France WORKING EXPERIENCES Permanent positions Since 2011 Since 2003 Since 1997 Since 1997 Since 1988 Since 1987 Head of the Infectious Diseases Unit of Ibn Rochd University Hospital. Member of the National Committee of Management of HIV infection () Responsibility of ARVs quantification for the treatment of HIV infected patients in In charge of HIV infection course in the Medical School of Casablanca National Board member of Association de Lutte Contre le Sida Physician in charge of management of HIV infection in the Infectious Diseases Unit of Ibn Rochd University Hospital Academic positions (Medical School of Casablanca) 1993 Professor of Infectious Diseases Associate Professor Assistant Resident Medical student training

4 INVOLVEMENT IN RESEARCH GRANTS : Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT001), a randomized, open label, phase III, international study of subcutaneous recombinant interleukin-2 (Proleukin ) in patients with HIV-1 infection and CD4 + Cell Counts 300/mm 3. Site principal investigator: Hakima Himmich The site of the Infectious Diseases Unit of Ibn Rochd University Hospital has enrolled 26 participants. Role in this research: Site co- investigator. Amount of money in the research grant: GBP : Study of Aldesleukin with and without Antiretroviral Therapy (STALWART : ESPRIT002), a randomized, open-label, international study of subcutaneous recombinant interleukin-2 (Aldesleukin ) with and without concomitant antiretroviral therapy in patients with HIV-1 infection and CD4 + Cell Counts 300/mm 3. Site principal investigator: Hakima Himmich The site of the Infectious Diseases Unit of Ibn Rochd University Hospital has enrolled 1 patient. Role in this research: Site co- investigator. Amount of money in the research grant: GBP : The SMART Study, a large, simple trial comparing the long-term clinical consequences of two Strategies for Management of Anti-Retroviral Therapy (Protocol CPCRA 065), the drug conservation strategy, a strategy aimed at conserving drugs through episodic use of antiretroviral treatment for the minimum time to maintain CD4+ cell count > 250 cells/mm3 versus the viral suppression strategy, a strategy aimed at suppressing viral load as much as possible, immediately following randomization and throughout follow up, irrespective of CD4+ cell count. Site principal investigator: Hakima Himmich The site of the Infectious Diseases Unit of Ibn Rochd University Hospital has enrolled 42 patients. Role in this research: Site investigator. Amount of money in the research grant: USD ongoing : Strategic Timing of AntiRetroviral Treatment (START), a randomized study to determine whether immediate initiation of antiretroviral treatment (ART) is superior to deferral of ART until the CD4+ declines below 350 cells/mm 3 in terms of morbidity and mortality in HIV-1 infected persons who are antiretroviral naïve with a CD4+ count above 500 cells/mm 3. The site of the Infectious Diseases Unit of Ibn Rochd University Hospital has included 21 patients and the enrolment is ongoing. Role in this research: site principal investigator. Amount of money in the research grant: USD (if the goal of 50 patients is reached) : The Antiretroviral Treatment in Lower Income Countries (ART-LINC) Collaboration to define prognosis of HIV-infected patients treated with HAART in resourcepoor settings, to compare experiences between different settings, delivery modes, and types of monitoring and to compare prognosis in resource-limited settings with that observed in industrialized nations. Principal investigators: François Dabis, Mathias Egger, Mauro Schechter The site of the Infectious Diseases Unit of Ibn Rochd University Hospital has participated with its cohort data. Role in this research: clinic representative. Research conducted by the University of Bern and the University of Bordeaux. Financial support of ANRS (France), CIHR (Canada) and NIH. Amount of money in the research grant: USD

5 CONSULTATIONS AND PROGRAMMATIC EXPERIENCE 2011 Consultation on provider initiated HIV testing in health care settings 2010 Consultation on HIV prophylaxis in case of sexual violence 2006 Consultation on sharp waste management in hospital (2 nd phase) 2004 Consultation on sharp waste management in hospital 2003 Assessment and strengthening of referral centers for HIV infection management 2001 Consultation on implementation of Access Initiative Republic of Congo UNAIDS Since 2000 Coordinator of the education program for patients under ART 2000 Contribution to the development of an African consensus on ART Casablanca Dakar, Senegal Infectious diseases unit/gsk foundation Since 1997 Consultation on ARVs procurement and supplying Since 1993 Collaboration with the National AIDS Program REGIONAL EXPERIENCE March 2009 July 2007 Syria : Consultation for the development of the GFATM proposal (WHO). Yemen : Consultation on ART for the NAP at ART sites of Sanaa and Aden (WHO) Member of the steering group of Antiretroviral Therapy in Low Income Countries (ART- LINC) collaboration Since 1994 July 2001 (Casablanca) : HIV Infection management Republic of Congo : Program Access of UNAIDS France (Paris) : HIV infection management (Casablanca) : Infectious diseases management (Casablanca) : Internal medicine diseases management.

6 PUBLICATIONS 1. Sodqi M, Marih L, Oulad Lahsen A, Bensghir R, Chakib A, Himmich H, Marhoum El Filali K. Causes de décès de 91 patients ayant une infection à VIH traités par des antirétroviraux. La Presse Médicale 2012, in press 2. Fane M, Oulad Lahsen A, Bakhatar A, Sodqi M, Marhoum El Filali K, Bahlaoui A, Chakib A. Aspergilose pulmonaire et infection à VIH (à propos de deux cas). Rev Pneumol Clin 2012, 68, 1 : Oulad Lahsen A, Rachidi T, Sodqi M, Abada R, Marhoum El Filali K. Paralysie faciale associée à la leptospirose. Médecine et Maladies Infectieuses 2010; 40, 12 : Bakhouch K, Oulad-Lahcen A, Bensghir R, Blaghen M, Marhoum El Filali K, Ezzikouri S, Abidi O, Hassar M, Wakrim L. The prevalence of resistance-associated mutations to protease and reverse transcriptase inhibitors in treatment-naïve HIV1-infected individuals in Casablanca,. J Infect Dev Ctries 2009; 3(5): Kamal Marhoum El Filali, Hakima Himmich, Bloodstream infections. In : a guide to infection control in hospital (fourth edition), R. Wenzel, G. Bearman, T. Brewer, J.P. Butzler (Eds). Brookline, 2008 ; Sandrine Loubière, Kamal Marhoum El Filali, Mustapha Sodqi, Anderson Loundou, Stéphane Luchini, Susan Cleary, Jean-Paul Moatti, Hakima Himmich. When to initiate highly active antiretroviral therapy in low resource settings : the Moroccan experience. Antiviral Therapy 2008 ; 13 : Gaëlle Krikorian, Kamal Marhoum El Filali, Hakima Himmich. L accès aux médicaments sous le nouveau régime de protection des brevets : cas du sida au Maroc. Knowledge Ecology Studies 2008 ; Vol.2 (Journal on-line : 8. ART-LINC Collaboration. Antiretroviral Therapy in Lower Income Countries (ART-LINC): International collaboration of treatment cohorts. Int J Epidemiol Oct;34(5): Marih L, Sodqi M, Chakib A, Malmoussi M, Ouagari Z, Marhoum El Filali K, Himmich H. Kaposi cutané de forme tumorale: difficultés diagnostiques à propos d un cas. Rev Maroc Med Santé 2005, 22, 1 : Guide de la prise en charge de l infection à VIH. Edité par le Ministère de la Santé, avec le soutien de l OMS, sous la coordination du Pr Hakima Himmich, Rabat, Malmoussi M, Zerouali K, Aajly L, Marhoum El Filali K, El Mdaghri N, Benbachir M, Himmich H. Méningite à méningocoque de l adulte à propos de 117 cas. J Magh A Réa 2003, 43 : Marih l, Sodqi M, Bensghir R, Marhoum El Filali K, Himmich H. Monitoring for efficacy of HAART in limited resource countries. Proceeding of International AIDS Conference, July Sodqi M, Marih L, Marhoum El Filali K, Himmich H. Infection with Mycobacterium tuberculosis among HIV infected patients in. Proceedings of the XIV International AIDS Conference. July Barcelone. 14. Soussi-Abdallaoui M, El Kadioui-El Idrissi F, Chakib A, Marhoum El Filali K, Himmich H, Guessous-Idrissi N. Isospora belli au Maroc à propos de 4 nouveaux cas. Les Cahiers du Medecin 2002, 48 : Marhoum El Filali K, A Chakib, Himmich H. Accès aux antirétroviraux au Maroc. Bulletin S.M.S.M 1999, 1 : Marhoum El Filali K. Prise en charge d un malade infecté par le VIH. Les cahiers du Médecin 1998 ; 11 : Marhoum El Filali K. Prophylaxie de l infection à VIH après une exposition accidentelle au sang. Les cahiers du Médecin 1998 ; 11 : Zahraoui M, Arssi M, Marhoum El Filali K, Chakib A, Himmich H. Tuberculose et infection par le VIH. Rev Maroc Med Santé 1992, 14,1 : 7-12