Journal of Infectious Diseases Advance Access published January 26, 2015
|
|
- Jacob Gilmore
- 8 years ago
- Views:
Transcription
1 Journal of Infectious Diseases Advance Access published January 26, Effect of immune status on serial QuantiFERON-TB Gold In-Tube LTBI screening in persons with HIV in a low TB incidence country Monica Sañé Schepisi 1, Mario Pasquale Parracino 1, Alessia Mammone 1, Rita Bellagamba 2, Carmela Pinnetti 2, Stefania Cicalini 2, Alessandro Sampaolesi 2, Adriana Ammassari 2, Delia Goletti 1 and Enrico Girardi 1 1 Department of Epidemiology and Preclinical Research 2 Clinical Department, National Institute for Infectious Diseases (INMI) L. Spallanzani, IRCCS, Rome, Italy Corresponding author contact information: Enrico Girardi, MD, Director, Clinical Epidemiology Unit - Department of Epidemiology and Preclinical Research Istituto Nazionale Malattie Infettive "L. Spallanzani" IRCCS Via Portuense 292, Roma Italy. tel (+39) Fax (+39) enrico.girardi@inmi.it The Author Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please journals.permissions@oup.com.
2 2 To the Editor: We read the article by Aichelburg et al. [1] with great interest. This 3 year prospective study reported the incidence of Interferon-Gamma Release Assays (IGRA) conversions and reversions within a cohort of HIV-infected individuals in a low tuberculosis (TB) incidence country. Concordant baseline and follow-up results of QuantiFERON-TB Gold In-Tube (QFT-GIT) were found in 86% of 794 HIV-infected individuals, while 9% of those initially converted to a positive result and 33% of those initially positive reverted to. Screening for latent TB infection (LTBI) and preventive treatment of those testing positive is widely recommended for persons living with HIV/AIDS (PLWHA). Current Center for Disease Control and Prevention and National Institute of Health Guidelines, recommend testing all HIV-infected persons with the tuberculin skin test (TST) or an IGRA [2]. For individuals with diagnostic tests for LTBI who have advanced HIV infection, screening should be repeated after initiation of antiretroviral (ART) treatment and CD4 cell increase [3]. This latter recommendation is supported by the results of studies conducted in low TB burden countries [4 6], showing TST conversion rates up to 11.8% among HIV-positive patients following ART induced immune system recovery. Similar evidence, however, is not available for IGRAs. We conducted a cohort study at the National Institute for Infectious Diseases (INMI) L. Spallanzani, in Rome, Italy, in order to assess the potential utility of repeating QFT-GIT testing in a cohort of >18 year old HIV-infected patients. Participants were included in the study if they were HIVinfected and underwent screening for LTBI by QFT-GIT form June 2006 to June Suspicion of active TB at the time of first testing and diagnosis of TB within 1 month of QFT-GIT testing were exclusion criteria. Study participants were offered a second QFT-GIT between January 2013 and June Main outcome measures in the analysis were frequency of conversion or reversion of QFT-GIT. In contrast to Aichelburg et al., who considered CD4 cell count at nadir and enrollment, we focused our analysis on CD4 cell count variation as a potential determinant of QFT-GIT conversion and reversion over the follow-up period.
3 3 In the analysis, 193 HIV-infected patients were included. At baseline, their average CD4 cell count was 325/μl (IQR ). A total of 115 subjects (59.6%) were antiretroviral naive or were on ART <1 month. Plasma HIV RNA <50 copies/ml was found in 41/167 subjects (24.6%). QFT-GIT was positive in 15 cases (7.8%) and indeterminate in 13 cases (6.7%). A positive test result was associated with being born in countries with higher TB incidence) and with higher CD4 cell count. In subjects born in countries with <20/100,000 TB incidence (n=163) there were 9 QFT- GIT positives (5.5%), whereas among those born in countries with TB incidence >20/100,000 (n=30) 6 had positive test results (20.0%) (OR 3.8, 95%CI ; p<0.05). Percentages of positive QFT paralleled increasing CD4 cell ranges: 1.9% (1/54), 4.5% (1/22) and 11.1% (13/117) among subjects with CD4 cell count between 0-99/μl, /μl and >200 cells/μl, respectively (p<0.05 for linear trend). After a median follow-up of 2.6 years (IQR, ), all patients were on ART and average CD4 cell counts increased to 523 cells/μl (IQR, ), with 78.5% of subjects having HIV RNA <50 copies/ml. At test repetition, 3 among 165 initially QFT-GIT (1.8%) converted to positive, 4 among 15 initially positive (26.6%) reverted to, and all those who had indeterminate results tested [Figure 1]. Overall, concordant baseline and follow-up results were observed in 172/193 (89.1%) subjects. At follow-up, average CD4 cell count increased by 206/ul in the conversion group and by 200/ul (from 337 to 537) in the concordant patients. In contrast, an average decline of 17 CD4 cells/ul was found in the reversion group [Figure 1]. The findings of our prospective study confirm the percentages of QFT-GIT concordance and reversion found by Aichelburg et al., while conversion was reported less frequently among our patients. Although our findings should be regarded as preliminary due the limited size of the study population, they may support the hypothesis that differences in QFT-GIT results over time might be determined by the variation in immunological condition, and that conversions may reflect immune reconstitution in individuals with unrevealed LTBI who were falsely at enrolment. A large cohort study would be needed to confirm this hypothesis and to evaluate the utility of repeated IGRA testing in order to identify candidates for LTBI treatment among persons with HIV infection.
4 4 Footnotes The authors have no conflicts of interest to declare. This study was supported in part through funds provided by the 2009 AIDS Programme-Italian Ministry of Health. This work was presented in part as an oral presentation at the 2013 Annual Congress of the European Respiratory Society in Barcelona, Spain. Corresponding author contact information: Enrico Girardi, MD Director, Clinical Epidemiology Unit - Department of Epidemiology and Preclinical Research Istituto Nazionale Malattie Infettive "L. Spallanzani" IRCCS Via Portuense 292, Roma Italy. tel (+39) Fax (+39) enrico.girardi@inmi.it Figure Legend Figure 1. QuantiFERON-TB Gold In-Tube results and CD4+ average CD4+ cell count variation over time in 193 HIV-1 infected persons.
5 5 References [1] Aichelburg MC, Reiberger T, Breitenecker F, Mandorfer M, Makristathis A, Rieger A.J. Reversion and conversion of interferon-γ release assay results in HIV-1-infected individuals. Infect Dis Mar 1;209(5): [2] Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castros K. Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection United States, Morbidity and Mortality Weekly Report. 2010;59(RR05):1 25. [3] Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. Available at accessed October 2014 [4] Schluger N W, Perez D, Liu Y M. Reconstitution of immune responses to tuberculosis in patients with HIV infection who receive antiretroviral therapy. Chest 2002; 122: [5] Girardi E, Palmieri F, Zaccarelli M, et al. High incidence of tuberculin skin test conversion among HIV-infected individuals who have a favourable immunological response to highly active antiretroviral therapy. AIDS 2002; 16: [6] Fisk T L, Hon H M, Lennox J L, Fordham von Reyn C, Hors- burgh C R Jr. Detection of latent tuberculosis among HIV- infected patients after initiation of highly active antiretroviral therapy. AIDS 2003; 17: [7] Pai M1, Joshi R, Dogra S, Zwerling AA, Gajalakshmi D, Goswami K, Reddy MV, Kalantri A, Hill PC, Menzies D, Hopewell PC.T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India. Int J Tuberc Lung Dis Jan;13(1):84-92.
6 6 Figure 1. QuantiFERON-TB Gold In-Tube results and CD4+ average CD4+ cell count variation over time in 193 HIV-1 infected persons. Baseline Follow up 161 (97.0%) +196 CD4+ cells/ l (from 328 to 524) 165 (85.5%) 329 CD4+ cells/ l 3 (1.2%) positive +206 CD4+ cells/ l (from 421 to 627) 1 (0.6%) indeterminate 142 CD4+ cells/ l (from 204 to 62) 193 HIV infected 325 CD4+ cells/ l 13 (6.7%) indeterminate 140 CD4+ cells/ l 13 (100%) +267 CD4+ cells/ l (from 140 to 407) 4 (26.7%) 17 CD4+ cells/ l (from 367 to 350) 15 (7.8%) positive 444 CD4+ cells/ l 11 (73.3%) positive +257 CD4+ cells/ l (from 472 to 729)
T tuberculin Skin Test (TST) and QFT-GIT in Military Personnel
2 COMPARISON OF MANTOUX AND QUANTIFERON-TB GOLD TEST FOR DIAGNOSIS OF LATENT TUBERCULOSIS INFECTION IN ARMY PERSONNEL Willeke P.J. Franken 1, Joost F. Timmermans 2, Corine Prins 1, Evert-Jan H.J. Slootman
More informationGuidelines for TB Blood Testing. Minnesota Department of Health TB Prevention and Control Program June 2011
Guidelines for TB Blood Testing Minnesota Department of Health TB Prevention and Control Program June 2011 Outline Interferon-Gamma Release Assays aka TB blood tests 1. What are they? 2. What are the current
More informationLisa Y. Armitige, MD, PhD has the following disclosures to make:
Interferon Gamma Release Assays (IGRAs) Lisa Y. Armitige, MD, PhD May 13, 2015 TB for Pulmonologist Phoenix, AZ March 13, 2015 EXCELLENCE EXPERTISE INNOVATION Lisa Y. Armitige, MD, PhD has the following
More informationHealth Protection Agency position statement on the use of Interferon Gamma Release Assay (IGRA) tests for Tuberculosis (TB)
Health Protection Agency position statement on the use of Interferon Gamma Release Assay (IGRA) tests for Tuberculosis (TB) Draft Interim HPA Guidance HPA Tuberculosis Programme Board Health Protection
More informationCDC TB Testing Guidelines and Recent Literature Update
Pocket Guide QuantiFERON -TB Gold CDC TB Testing Guidelines and Recent Literature Update Using IGRAs for TB screening in your patients June 2010 A full copy of the US Centers for Disease Control and Prevention
More informationInterferon-gamma Release Assays: the Good, the Bad, and the Ugly
Interferon-gamma Release Assays: the Good, the Bad, and the Ugly Susan E. Dorman, MD Center for TB Research Johns Hopkins University School of Medicine Maryland Center for Tuberculosis Control and Prevention
More informationInterferon-gamma-release assays: Better than tuberculin skin testing?
REVIEW CME CREDIT EDUCATIONAL OBJECTIVE: Readers will use and interpret the new blood tests for tuberculosis correctly CYNDEE MIRANDA, MD Department of Infectious Disease, Medicine Institute, Cleveland
More informationWhat is an IGRA? What is an IGRA? Are they available here? How do I use them? Learning Objectives
What is an IGRA? Are they available here? How do I use them? Debbie Staley, RN, MPH TB Nurse Consultant VDH Division of Disease Prevention TB Control Program Learning Objectives Participants will be able
More informationRole of Quantiferon-TB Gold Assays in Detecting Latent Tuberculous Infection among Contacts of Active Tuberculous Patients *
Med. J. Cairo Univ., Vol. 79, No. 1, June 169-175, 2011 www.medicaljournalofcairouniversity.com Role of Quantiferon-TB Gold Assays in Detecting Latent Tuberculous Infection among Contacts of Active Tuberculous
More informationTargeted Testing for Tuberculosis Infection
Targeted Testing for Tuberculosis Infection CONTENTS Introduction... 3.2 Purpose... 3.2 Policy... 3.2 When to Conduct Targeted Testing... 3.3 Approaches to increasing targeted testing and treatment for
More informationDRAFT FOR CONSULTATION
Interferon Gamma Release Assay (IGRA) testing for tuberculosis (TB) - Questions & Answers (Q&As) For Health Care Workers HPA Tuberculosis Programme Board DRAFT FOR CONSULTATION October 2007 Interferon
More informationAn Evaluation of QuantiFERON-TB Gold In-Tube and Immunological Tests for TB Diagnosis in Iraqi Patients
An Evaluation of QuantiFERON-TB Gold In-Tube and Immunological Tests for TB Diagnosis in Iraqi Patients Mohemid M. Al-Jebouri 1 and Nuha M. Wahid 2 1 Department of Microbiology, College of Medicine, University
More informationTB Intensive San Antonio, Texas November 11 14, 2014
TB Intensive San Antonio, Texas November 11 14, 2014 TB in the HIV Patient Lisa Armitige, MD, PhD November 13, 2014 Lisa Armitige, MD, PhD has the following disclosures to make: No conflict of interests
More informationRefugees with diabetes mellitus have higher prevalence of latent tuberculosis infection
Refugees with diabetes mellitus have higher prevalence of latent tuberculosis infection Matthew Magee Division of Epidemiology and Biostatistics School of Public Health, Georgia State University Saturday,
More informationTuberculosis. Subject. Goal/Objective. Instructions. Rationale. Operations Directorate, Health Branch Immigration Medical Examination Instructions
Subject Instructions for the screening of clients to detect tuberculosis (TB) in the context of the Canadian immigration medical examination (IME). Goal/Objective These instructions are provided to ensure
More informationPotential impact of routine testing of patients with HIV indicator disease in preventing late HIV diagnosis
Potential impact of routine testing of patients with HIV indicator disease in preventing late HIV diagnosis Enrico Girardi, P. Scognamiglio, G. Chiaradia, F. Salvatori, P. Elia, M. Giuliani, S. Aviani,
More informationRecent Advances in The Treatment of Mycobacterium Tuberculosis
Recent Advances in The Treatment of Mycobacterium Tuberculosis Dr Mohd Arif Mohd Zim Senior Lecturer & Respiratory Physician Faculty of Medicine, Universiti Teknologi MARA mohdarif035@salam.uitm.edu.my
More informationT()LED() Name ofpolicy: Mandatory Tuberculosis (TB) Screening of Students from World Health Organization Designated High TB Prevalence Countries
Name ofpolicy: Mandatory Tuberculosis (TB) Screening of Students from World Health Organization Designated High TB Prevalence Countries Policy Number: 3364-81-04-030 T()LED() Revision date: I 0/22/13 Approving
More informationSPECIAL FEATURES: HEALTH POLICY
Public Health Nursing 0737-1209/ 2013 Wiley Periodicals, Inc. doi: 10.1111/phn.12083 SPECIAL FEATURES: HEALTH POLICY Cost-effectiveness of Using Quantiferon Gold (QFT-G) versus Tuberculin Skin Test (TST)
More informationPediatric Latent TB Diagnosis and Treatment
Date Updated: April 2015 Guidelines Reviewed: 1. CDC Latent TB Guidelines 2. Harborview Pediatric Clinic Latent TB Management, 2010 3. Pediatric Associates Latent TB Guidelines, 2013 4. Seattle Children
More informationChapter 3 Testing for Tuberculosis Infection and Disease
Chapter 3 Testing for Tuberculosis Infection and Disease Table of Contents Chapter Objectives.... 45 Introduction.... 47 Identifying High-Risk Groups for M. tuberculosis Testing... 47 Testing Methods for
More informationATTACHMENT 2. New Jersey Department of Health Tuberculosis Program FREQUENTLY ASKED QUESTIONS
ATTACHMENT 2 New Jersey Department of Health Tuberculosis Program FREQUENTLY ASKED QUESTIONS 1. QUESTION Is it required to submit the Annual Report of TB Testing in Schools Form (TB-57) to the New Jersey
More informationPerils and Pitfalls in Clinical Trials of Diagnostic Tests for Tuberculosis. Richard O Brien, MD Foundation for Innovative New Diagnostics Geneva
Perils and Pitfalls in Clinical Trials of Diagnostic Tests for Tuberculosis Richard O Brien, MD Foundation for Innovative New Diagnostics Geneva 1 Outline of Presentation Statement of the problem Common
More informationTuberculosis in children in Europe -the ptbnet
Tuberculosis in children in Europe -the ptbnet Beate Kampmann FRCPCH PhD A/Professor in Paediatric Infection & Immunity Consultant Paediatrician Imperial College London, UK and Institute of Infectious
More informationHow To Test For Latent Tuberculosis
IGRAs: What do they tell and what don t they tell us? 2 nd European Advanced Clinical Tuberculosis Course Monday 22 nd September 2014 Amsterdam, Netherlands Ibrahim Abubakar Professor of Infectious Disease
More informationMaria Dalbey RN. BSN, MA, MBA March 17 th, 2015
Maria Dalbey RN. BSN, MA, MBA March 17 th, 2015 2 Objectives Participants will be able to : Understand the Pathogenesis of Tuberculosis (TB) Identify the Goals of Public Health for TB Identify Hierarchy
More informationMassachusetts Department of Public Health Division of Global Populations and Infectious Disease Prevention
Massachusetts Department of Public Health Division of Global Populations and Infectious Disease Prevention Screening Infants and Children for Tuberculosis in Massachusetts Executive Summary In Massachusetts,
More informationTuberculosis (TB) Screening Guidelines for Substance Use Disorder Treatment Programs in California
Tuberculosis (TB) Screening Guidelines for Substance Use Disorder Treatment Programs in California 1 of 7 Table of Contents Preface 2 TB Symptoms and TB History 2 Initial Screening 2 Follow-Up Screening
More informationPaediatrica Indonesiana. Limitations of the Indonesian Pediatric Tuberculosis Scoring System in the context of child contact investigation
Paediatrica Indonesiana VOLUME 51 November NUMBER 6 Original Article Limitations of the Indonesian Pediatric Tuberculosis Scoring System in the context of child contact investigation Rina Triasih 1,2,
More informationSerial Testing of Refugees for Latent Tuberculosis Using the QuantiFERON-Gold In-Tube: Effects of an Antecedent Tuberculin Skin Test
Am. J. Trop. Med. Hyg., 80(4), 2009, pp. 628 633 Copyright 2009 by The American Society of Tropical Medicine and Hygiene Serial Testing of Refugees for Latent Tuberculosis Using the QuantiFERON-Gold In-Tube:
More informationTuberculosis Contact Investigation in a Renal Dialysis Center: Blood Vs. Skin test
Tuberculosis Contact Investigation in a Renal Dialysis Center: Blood Vs. Skin test Kevin L. Winthrop M.D., M.P.H. Assistant Professor of Medicine Divisions of Infectious Diseases and Public Health and
More informationTuberculosis Exposure Control Plan for Low Risk Dental Offices
Tuberculosis Exposure Control Plan for Low Risk Dental Offices A. BACKGROUND According to the CDC, approximately one-third of the world s population, almost two billion people, are infected with tuberculosis.
More informationNevada State Health Division Technical Bulletin
Nevada State Health Division Technical Bulletin Topic: Using QuantiFERON and Tuberculin Skin Test to Screen for TB Section/Program/Contact: Bureau of Community Health / Tuberculosis Program / Susanne Paulson,
More informationUpdated Guidelines for Using Interferon Gamma Release Assays to Detect Mycobacterium tuberculosis Infection United States, 2010
Morbidity and Mortality Weekly Report www.cdc.gov/mmwr Recommendations and Reports June 25, 2010 / Vol. 59 / No. RR-5 Updated Guidelines for Using Interferon Gamma Release Assays to Detect Mycobacterium
More informationWhat You Need to Know About Collecting QuantiFERON (QFT) TB Gold In-Tube Samples
What You Need to Know About Collecting QuantiFERON (QFT) TB Gold In-Tube Samples I. What is QuantiFERON (QFT) TB Gold In-Tube? II. III. QFT is an interferon-gamma release assay (IGRA). QFT is a blood test.
More informationImmunology Platform 2012
Immunology Platform 2012 The scientific activity report of Immunology Platform of the Institut Pasteur du Cambodge for the period January 1st to December 31st, 2012. Scientific activity report Prepared
More informationDIVISION of SUBSTANCE ABUSE SERVICES. Tuberculosis Control Guidelines for Alcohol and Drug Abuse Treatment Programs
DIVISION of SUBSTANCE ABUSE SERVICES Tuberculosis Control Guidelines for Alcohol and Drug Abuse Treatment Programs 1. Purpose: This policy provides guidance and instruction to identify and prevent tuberculosis
More informationChildhood Tuberculosis Some Basic Issues. Jeffrey R. Starke, M.D. Baylor College of Medicine
Childhood Tuberculosis Some Basic Issues Jeffrey R. Starke, M.D. Baylor College of Medicine TUBERCULOSIS IS A SOCIAL DISEASE WITH MEDICAL IMPLICATIONS THE GREAT PARADOX OF TUBERCULOSIS A CAUTIONARY TALE
More informationSanta Clara County Tuberculosis Screening Requirement for School Entrance Effective June 1, 2014. Frequently Asked Questions
Frequently Asked Questions A child has history of BCG vaccination, should they have TST or IGRA? According to the American Academy of Pediatrics Red Book (2012), Interferon Gamma Release Assay (IGRA) is
More informationPoster # 42 Resistance in PBMCs Can Predict Virological Rebound after Therapy Switch in cart- Treated Patients with Undetectable HIV-RNA
Poster # 42 Resistance in PBMCs Can Predict Virological Rebound after Therapy Switch in cart- Treated Patients with Undetectable HIV-RNA D Armenia 1, M Zaccarelli 2, V Borghi 3, W Gennari 3, A Giannetti
More informationAssisted Living - TB Risk Assessment
Montana DPHHS Tuberculosis Program Assisted Living - TB Risk Assessment Assisted Living, Adult Day Care, Adult Foster Care & Transitional Living Centers Today s Date Facility Address Phone County Completed
More informationSan Francisco Guidelines on the Use of QuantiFERON-TB Gold (In Tube Method) for the Diagnosis of Latent TB Infection
San Francisco Guidelines on the Use of QuantiFERON-TB Gold (In Tube Method) for the Diagnosis of Latent TB Infection Rationale When to Screen for TB Choosing the Right TB Test Patient Registration Pre-Test
More informationGlobal Update on HIV Treatment 2013: Results, Impact and Opportunities
June 2013 Global Update on HIV Treatment 2013: Results, Impact and Opportunities WHO/UNAIDS/UNICEF v2 Outline Results: Progress towards Global Targets - Antiretroviral treatment - Prevention of mother-to-child
More informationChapter 1 Overview of Tuberculosis Epidemiology in the United States
Chapter 1 Overview of Tuberculosis Epidemiology in the United States Table of Contents Chapter Objectives.... 1 Progress Toward TB Elimination in the United States.... 3 TB Disease Trends in the United
More informationTUBERCULOSIS SCREENING AND TREATMENT IN PREGNANCY. Stephanie N. Lin MD 2/12/2016
TUBERCULOSIS SCREENING AND TREATMENT IN PREGNANCY Stephanie N. Lin MD 2/12/2016 Epidemiology of TB 9.6 million new cases in 2014 12% of them are in HIV positive patients 1.5 million deaths in 2014 ~646
More informationUniversity of Nebraska Medical Center, Department of Health Services Research and Administration, Omaha, NE
Research Mycobacterium Tuberculosis Infection, Immigration Status, and Diagnostic Discordance: A Comparison of Tuberculin Skin Test and QuantiFERON -TB Gold In-Tube Test Among Immigrants to the U.S. Fernando
More informationManaging Contacts. Challenges... 202. General Principles... 204. Summary of Options... 205. Variables to Consider... 205. Treatment Options...
10 Managing Contacts Challenges............ 202 General Principles...... 204 Summary of Options.... 205 Variables to Consider... 205 Treatment Options...... 206 Treatment of Children... 209 Window Prophylaxis....
More informationFrequently Asked Questions
Frequently Asked Questions QuantiFERON -TB Gold Health Professionals www.quantiferon.com 2 FAQ - Health Professionals Table of contents About TB 6 What is latent TB? And how is it different from active
More informationSerial Testing for TB Infection with IGRAs: Understanding the Sources of Variability
Serial Testing for TB Infection with IGRAs: Understanding the Sources of Variability Niaz Banaei MD Assistant Professor of Pathology and Medicine Director, Fellowship in Global Health Diagnostics Director,
More informationTuberculosis Prevention and Control Protocol, 2008
Tuberculosis Prevention and Control Protocol, 2008 Preamble The Ontario Public Health Standards (OPHS) are published by the Minister of Health and Long- Term Care under the authority of the Health Protection
More informationTB preventive therapy in children. Introduction
TB preventive therapy in children H S Schaaf Department of Paediatrics and Child Health, and Desmond Tutu TB Centre Stellenbosch University, and Tygerberg Children s Hospital Introduction Children are
More informationMaryland County Health Department Tuberculosis Infection Control Plan
Maryland County Health Department Tuberculosis Infection Control Plan Introduction In 1998, the Division of TB Control developed a Tuberculosis (TB) Prevention Plan template for use by the local health
More informationTuberculosis and HIV/AIDS Co-Infection: Epidemiology and Public Health Challenges
Tuberculosis and HIV/AIDS Co-Infection: Epidemiology and Public Health Challenges John B. Kaneene, DVM, MPH, PhD University Distinguished Professor of Epidemiology Director, Center for Comparative Epidemiology
More informationFEDERAL BUREAU OF PRISONS REPORT ON INFECTIOUS DISEASE MANAGEMENT
FEDERAL BUREAU OF PRISONS REPORT ON INFECTIOUS DISEASE MANAGEMENT What is the purpose of this report? The purpose of this report is to present the administrative policies and clinical guidelines for the
More informationScreening and preventive therapy for MDR/XDR-TB exposed/infected children (and adults)
Screening and preventive therapy for MDR/XDR-TB exposed/infected children (and adults) H S Schaaf Department of Paediatrics and Child Health, and Desmond Tutu TB Centre Stellenbosch University, and Tygerberg
More informationRisk for Tuberculosis in Swiss Hospitals. Content. Introduction. Dr. med. Alexander Turk Zürcher Höhenklinik Wald alexander.turk@zhw.
Risk for Tuberculosis in Swiss Hospitals 17. Tuberkulose Symposium Münchenwiler Risk for Tuberculosis in Swiss Hospitals Dr. med. Alexander Turk Zürcher Höhenklinik Wald alexander.turk@zhw.ch 1 Content
More informationGuideline. Treatment of tuberculosis in patients with HIV co-infection. Version 3.0
Guideline Treatment of tuberculosis in patients with HIV co-infection Version 3.0 Key critical points Co-infection with Tuberculosis (TB) and HIV is common in many parts of the world, especially sub-saharan
More informationNotes. Complete childhood vaccination course (CCV) CCV and DTP booster as adolescent/adult within last 10 years
Student Immunisation Record School of Nursing, Midwifery and Social Work Section 1: Information for students enrolled in Nursing and Midwifery programs Students enrolled in programs offered by our School
More informationECDC GUIDANCE. Investigation and control of tuberculosis incidents affecting children in congregate settings. www.ecdc.europa.eu
Investigation and control of tuberculosis incidents affecting children in congregate settings www.ecdc.europa.eu Investigation and control of tuberculosis incidents affecting children in congregate settings
More informationAssessing patients for infection with Mycobacterium tuberculosis
ORIGINAL STUDIES The Likelihood of an Indeterminate Test Result from a Whole-Blood Interferon- Release Assay for the Diagnosis of Mycobacterium tuberculosis Infection in Children Correlates With Age and
More informationPolicy Directive: compliance is mandatory
Policy Directive: compliance is mandatory Policy for Control of Tuberculosis in South Australian Health Services Policy developed by: Public Health and Clinical Coordination Approved at Portfolio Executive
More informationTUBERCULOSIS (TB) SCREENING GUIDELINES FOR RESIDENTIAL FACILITIES AND DRUG
TUBERCULOSIS (TB) SCREENING GUIDELINES FOR RESIDENTIAL FACILITIES AND DRUG Tx CENTERS Tuberculosis Control Program Health and Human Services Agency San Diego County INTRODUCTION Reducing TB disease requires
More informationCTCA POSITION ON TB EXAMINATION OF SCHOOL EMPLOYEES AND VOLUNTEERS
CTCA POSITION ON TB EXAMINATION OF SCHOOL EMPLOYEES AND VOLUNTEERS Introduction Although progress has been made, tuberculosis (TB) continues to be a significant public health problem; appropriate TB examination
More informationE s t i m at i n g d i a g n o s t i c a c c u r a c y o f t e s t s f o r l at e n t
R e s e a rc h a r ti cl e s E s t i m at i n g d i a g n o s t i c a c c u r a c y o f t e s t s f o r l at e n t t u b e r c u l o s i s i n f e c t i o n w i t h o u t a g o l d s ta n d a r d a m o
More informationComparison of Quantiferon-TB Gold versus Tuberculin Skin Test for Tuberculosis Screening in Inflammatory Bowel Disease Patients
Comparison of Quantiferon-TB Gold versus Tuberculin Skin Test for Tuberculosis Screening in Inflammatory Bowel Disease Patients Gianluca Andrisani, Alessandro Armuzzi, Alfredo Papa, Manuela Marzo, Carla
More informationPregnancy and Tuberculosis. Information for clinicians
Pregnancy and Tuberculosis Information for clinicians When to suspect Tuberculosis (TB)? Who is at risk of TB during pregnancy? Recent research suggests that new mothers are at an increased risk of TB
More informationBorderless Diseases By Sunny Thai
Borderless Diseases By Sunny Thai Millennium Development Goal #6 6. Combat HIV/AIDS, malaria and other borderless diseases. A. Halt and begin reversing spread of HIV by 2015. B. Achieve universal access
More informationTuberculosis Transmission in Households and Communities
Tuberculosis Transmission in Households and Communities Christopher C. Whalen, M.D., M.S. Department of Epidemiology and Biostatistics 2008, The University of Georgia. All rights reserved. Model for M.
More informationGUIDELINES FOR TUBERCULOSIS PREVENTIVE THERAPY AMONG HIV INFECTED INDIVIDUALS IN SOUTH AFRICA
GUIDELINES FOR TUBERCULOSIS PREVENTIVE THERAPY AMONG HIV INFECTED INDIVIDUALS IN SOUTH AFRICA 2010 1 TB prophylaxis GUIDELINES FOR TUBERCULOSIS PREVENTIVE THERAPY AMONG HIV INFECTED INDIVIDUALS Background
More informationAmerican College Health Association (ACHA) TB Screening and Targeted Testing Recommendations Gregory Juckett, MD, MPH Professor of Family Medicine
American College Health Association (ACHA) TB Screening and Targeted Testing Recommendations Gregory Juckett, MD, MPH Professor of Family Medicine West Virginia University gjuckett@hsc.wvu.edu Objectives
More informationPromise versus reality - Optimism bias in package inserts of TB diagnostics
Promise versus reality - Optimism bias in package inserts of TB diagnostics Claudia Denkinger, MD PhD Beth Israel Deaconess Medical Center, Boston McGill University, Montreal cdenking@bidmc.harvard.edu
More informationThe Cost Effectiveness of Interferon Gamma Release Assays Versus Tuberculin Skin Tests in Health Care
ORIGINAL INVESTIGATION Cost-effectiveness of Interferon Gamma Release Assays vs Tuberculin Skin Tests in Health Care Workers Marie A. de Perio, MD; Joel Tsevat, MD, MPH; Gary A. Roselle, MD; Stephen M.
More informationAppendix B: Provincial Case Definitions for Reportable Diseases
Infectious Diseases Protocol Appendix B: Provincial Case Definitions for Reportable Diseases Disease: Tuberculosis Revised August 2015 Tuberculosis 1.0 Provincial Reporting Confirmed and suspect cases
More informationSwitch to Dolutegravir plus Rilpivirine dual therapy in cart-experienced Subjects: an Italian cohort
Switch to Dolutegravir plus Rilpivirine dual therapy in cart-experienced Subjects: an Italian cohort Gaetana Sterrantino Azienda Ospedaliero-Universitaria Careggi Infectious diseases, Florence, Italy Background
More informationPublic Health and Correctional Collaboration in Tuberculosis Control
Public Health and Correctional Collaboration in Tuberculosis Control Mark N. Lobato, MD, Cheryl A. Roberts, MPA, Lauri B. Bazerman, MS, Theodore M. Hammett, PhD Objective: Methods: Results: Conclusions:
More informationTuberculosis And Diabetes. Dr. hanan abuelrus Prof.of internal medicine Assiut University
Tuberculosis And Diabetes Dr. hanan abuelrus Prof.of internal medicine Assiut University TUBERCULOSIS FACTS More than 9 million people fall sick with tuberculosis (TB) every year. Over 1.5 million die
More informationTuberculosis Case Management for Undocumented and Deportable Inmates/Prisoners/Detainees in Federal Custody
Background Federal Bureau of Prisons (BOP) Tuberculosis Case Management for Undocumented and Deportable Inmates/Prisoners/Detainees in Federal Custody Federal Bureau of Prisons (Department of Justice)
More informationAntiretroviral therapy for HIV infection in infants and children: Towards universal access
Antiretroviral therapy for HIV infection in infants and children: Towards universal access Executive summary of recommendations Preliminary version for program planning 2010 Executive summary Tremendous
More informationDepartment of Internal Medicine, Division of Cardiovascular Diseases. Department of Internal Medicine. Department of Internal Medicine
Use of the QuantiFERON -TB Gold Assay in Pregnant Patients Bassem M.Chehab, M.D. 1, K. James Kallail, Ph.D. 2, Riad O. El Fakih, M.D. 3, Rosalee E. Zackula, M.A. 4, Garold O. Minns, M.D. 2 1 University
More informationOpportunistic Infections Related to Immune Suppressant and Biologic Drug Therapy in IBD
Opportunistic Infections Related to Immune Suppressant and Biologic Drug Therapy in IBD Raymond Cross, M.D., M.S., AGAF Associate Professor of Medicine Director of the Inflammatory Bowel Disease Program
More informationRoutine HIV Monitoring
Routine HIV Monitoring Guideline of the HIV/AIDS Division at San Francisco General Hospital Statement of Guideline: Patients will be routinely evaluated and monitored for HIV parameters, antiretroviral
More informationGuidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents Visit the AIDSinfo website to access the most up-to-date guideline. Register for e-mail notification of guideline
More informationHow To Get A Job In California
HUMAN RESOURCES DIVISION - EMPLOYEE HEALTH SERVICES MEDICAL AND TUBERCULOSIS CLEARANCE FOR NEW CERTIFICATED EMPLOYEES To ensure the attached forms are valid at the time of submission, do not proceed with
More informationDetection of Multiple Double-Stranded DNA Viruses after Cord Blood Transplantation is Frequent and Persistent
Detection of Multiple Double-Stranded DNA Viruses after Cord Blood Transplantation is Frequent and Persistent Joshua A Hill, MD Bryan Mayer, PhD Hu Xie, MS Wendy Leisenring, PhD Filippo Milano, MD Meei-Li
More informationTuberculosis in Children and Adolescents
Tuberculosis in Children and Adolescents Ritu Banerjee, MD, Ph.D TB Clinical Intensive April 8, 2015 2014 MFMER slide-1 Disclosures None 2014 MFMER slide-2 Objectives Describe the epidemiology of pediatric
More informationNo influence of haemodialysis on interferon production in the QuantiFERON-TB Gold-In-Tube test
ORIGINAL ARTICLE JN EPHROL 24( 2011; 05) : 625-630 DOI:10.5301/JN.2011.6325 No influence of haemodialysis on interferon production in the QuantiFERON-TB Gold-In-Tube test Martine Hoogewerf 1, Greet J.
More informationDiagnosis of Tuberculosis Infection
Diagnosis of Tuberculosis Infection CONTENTS Introduction... 7.2 Purpose... 7.2 Policy... 7.2 High-Risk Groups... 7.3 Diagnosis of Tuberculosis Infection... 7.4 Interferon gamma release assays... 7.4 Mantoux
More informationAbstract. 1. Basic underlying view
_ Abstract 1. Basic underlying view Mycobacterium tuberculosis Table 1 2. LTBI treatment subjects 1. Basic view 2. TB development risk factors and infection diagnosis i. HIV/AIDS ii. Hemodialysis for
More informationIncidencia y Características Clínicas del Síndrome Inflamatorio de Reconstitución Inmune (IRIS) en el Contexto de la Coinfección VIH-TB
Incidencia y Características Clínicas del Síndrome Inflamatorio de Reconstitución Inmune (IRIS) en el Contexto de la Coinfección VIH-TB Dr. Christian Manzardo Hospital Clínic/IDIBAPS- Universidad de Barcelona
More informationCase Finding for Hepatitis B and Hepatitis C
Case Finding for Hepatitis B and Hepatitis C John W. Ward, M.D. Division of Viral Hepatitis Centers for Disease Control and Prevention Atlanta, Georgia, USA Division of Viral Hepatitis National Center
More informationClinical description 2 Laboratory test for diagnosis 3. Incubation period 4 Mode of transmission 4 Period of communicability 4
Tuberculosis Contents Epidemiology in New Zealand 2 Case definition 2 Clinical description 2 Laboratory test for diagnosis 3 Case classification 3 Spread of infection 4 Incubation period 4 Mode of transmission
More informationInterferon Gamma Release Assays (IGRAs) in the Diagnosis of Tuberculosis
Interferon Gamma Release Assays (IGRAs) in the Diagnosis of Tuberculosis Richard B. Clark, PhD, D(ABMM) Quest Diagnostics Nichols Institute Chantilly, VA Dale Schwab, PhD, D(ABMM) Quest Diagnostics Nichols
More information09/27/2006 Centers for Disease Control and Prevention Division of Tuberculosis Elimination
Appendix B. Tuberculosis (TB) risk assessment worksheet This model worksheet should be considered for use in performing TB risk assessments for healthcare facilities and nontraditional facility-based settings.
More informationRole of QuantiFERON-TB Gold In-Tube test in detection of latent tuberculosis infection in health care contacts in Alexandria, Egypt
Vol. 8(12), pp. 1310-1317, 19 March, 2014 DOI: 10.5897/AJMR2013.6502 ISSN 1996-0808 Copyright 2014 Author(s) retain the copyright of this article http://www.academicjournals.org/ajmr African Journal of
More informationLTBI Program Implementation in a Substance Abuse Treatment Facility
LTBI Program Implementation in a Substance Abuse Treatment Facility (A Case Study) Acknowledgments The New Jersey Medical School (NJMS) National Tuberculosis Center wishes to acknowledge the following
More informationSelf-Study Modules on Tuberculosis
Self-Study Modules on Tuberculosis Treatment of Latent Tuberculosis Infection and Tube rc ulos is Disease U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National
More informationPatient Education CONTENTS. Introduction... 12.2
CONTENTS Introduction... 12.2 Purpose... 12.2 General Guidelines... 12.3 Language and Comprehension Barriers... 12.4 Education Topics... 12.5 Medical Diagnosis... 12.5 Contact Investigation... 12.6 Isolation...
More informationGuidelines for Source Case Investigation (SCI) for Latent Tuberculosis (TB) Infection
Guidelines for Source Case Investigation (SCI) for Latent Tuberculosis (TB) Infection CDPH/CTCA Guidelines for Source Case Investigation (SCI) for Latent Tuberculosis (TB) Infection 21 1 of Table of Contents
More informationLong-term Care - TB Risk Assessment
Montana DPHHS Tuberculosis Program Long-term Care - TB Risk Assessment Long-term Care, Residential Treatment, ESRD (outpatient), Hospice (inpatient) Today s Date Facility Address Phone County Completed
More informationResearch Article Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening among Immigrant Visa Applicants
Tuberculosis Research and Treatment, Article ID 217969, 11 pages http://dx.doi.org/10.1155/2014/217969 Research Article Tuberculin Skin Tests versus Interferon-Gamma Release Assays in Tuberculosis Screening
More information