Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging

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1 International PhD Course,, March 2011 Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging Course Arranger and coordinator: Per Aagaard, Professor PhD Institute of Sports Science and Clinical Biomechanics, Course content: This PhD course will present and discuss various measuring methods and data related to the assessment of maximal muscle strength/power of human skeletal muscle, including explosive muscle strength, and the evaluation of neuromuscular function. Furthermore, methods to assess muscle morphology, fibertype composition and MHC distribution will be presented, along with a number of cellular and molecular analysis methods including measurements of mrna expression, satellite cell activation/proliferation and apoptosis signalling. Finally, various methods to assess tendon-aponeurosis function in vivo from the macro level to the molecular level will be presented and discussed. Presentations and discussions typically will address specific types of interventions (i.e. training, injury, immobilization) in relation to various clinical aspects and subject groups (i.e. athletes, patients, elderly, very old). Topics: muscle mechanical function, neuronal function, muscle morphology and architecture, myofibre growth and atrophy factors, apoptosis signalling, myogenic satellite cells, aging and sarcopenia, functional capacity in ADL, immobilization and disuse, assessment in patients with chronic diseases (osteoarthritis, chronic heart disease, chronic kidney disease, chronic pulmonary disease, stroke patients), tendinopathy and recurrent muscle strain injury, testing of elite athletes, aspects related to tendon and aponeurosis function in vivo. Time: 7 th to 12 th of March, 2011 Place: Institute of Sports Science and Clinical Biomechanics,, Campusvej 55, 5230 Odense, Denmark Language: English. Arranger: Per Aagaard, Professor PhD, Institute of Sports Science and Clinical Biomechanics, Scientific Lecturers: Per Aagaard, Jesper L. Andersen, Peter S. Magnusson, Peter Schjerling, Charlotte Suetta, Paolo Caserotti, Abigail Mackey-Sennels, Kristian Vissing, Markus Gruber, Jesper Lundbye-Jensen, Katja Heinemeier, Niels Ørtenblad, Ulrik Frandsen, Fawzi Kadi, Henning Langberg, Jens Bojsen-Møller, Mads Kongsgaard, Lars Holm, Lars L. Andersen. Format: 6 full days (Monday to Saturday), the course will be comprised of lectures and discussions led by a number of invited researchers, as well as presentations and discussion of the participants own projects. Course Fee: DKR 3000 (EUR 400,-) which covers all on-site course expenses including lunch, coffee and fruit all days, get-together event for all participants, and all study and teaching materials. Online registration: Deadline is February 1st, 2011.

2 Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging PROGRAMME I. Monday Introduction Per Aagaard Assessment and evaluation of muscle mechanical function in vivo - paradigms and applications Topics: Maximal muscle strength, explosive strength, contractile power, eccentric vs concentric muscle strength, muscle morphology and muscle architecture, young vs aging individuals, musculoskeletal injury settings, athlete evaluation, patients Speaker: Per Aagaard Assessment and evaluation of muscle tendon and aponeurosis function in vivo - paradigms and applications Topics: Tendon and aponeurosis stiffness and energy absorbtion, Speaker: Peter Magnusson Assessment and evaluation of muscle morphology, fibertype composition and MHC isoform distribution - paradigms and applications Topics: MHC, gel electrophoresis, histochemistry, effects of training, effects of chronic immobilization (spinal cord injury), aging, relationships to functional muscle performance Speaker: Jesper L. Andersen II. Tuesday Assessment and evaluation of neuronal function in vivo - paradigms and applications Topics: electromyography (EMG) recording and analysis, H reflex, V-wave, effects of training, twitch interpolation techniques, evoked motor potentials, TMS, TES, corticospinal excitability, relationships to mechanical muscle function Speakers: Per Aagaard, Markus Gruber, Jesper Lundbye-Jensen Molecular factors and mechanisms related to myofiber growth Topics: mrna, transcription factors, translation, real-time PCR, Western Blotting, Nothern Blotting, IGF- 1, myostatin, relationships to muscle function, effects of training, Speakers: Peter Schjerling, Jesper L. Andersen Alterations in myogenic satellite cell function induced by exercise Topics: assessment techniques, activation and inhibition of satellite cells, effects of training, aging, disuse Speakers: Abigail Mackey-Sennels, Fawzi Kadi

3 III. Wednesday Effects of exercise and training on tendon and aponeurosis function in vivo Topics: assessment techniques, ultrasonography, MRI, PET, biomechanical properties of tendon and aponeurosis in vivo, gender and training, effects of corticosteroid administration, atomic force microscopy, molecular biomechanics, effects of immobilization, aging aspects Speakers: Mads Kongsgaard, Jens Bojsen-Møller Molecular factors and mechanisms related to tendon growth and atrophy Topics: TGF-beta, IGF-1, estrogen, relationships to muscle-tendon function, effects of training Speakers: Katja Heinemeier, Henning Langberg Molecular mechanisms and treatment options for muscle atrophy and muscle wasting with disuse and disease age related aspects Topics: assessment techniques, disuse and aging, effects of training, Speakers: Charlotte Suetta, Ulrik Frandsen Cellular factors related to Ca 2+ kinetics, specific force production and glycogen compartmentalization implications for fatigue resistance and exercise capacity Topics: assessment techniques, effects of training, elite athletes, disuse, aging Speaker: Niels Ørtenblad The Akt AMPK switch mechanism: Antagonistic cellular signaling with resistance exercise vs endurance exercise? Topics: influence of exercise modality, AMPK, Akt, mtor, acute responses, longitudinal effects Speaker: Kristian Vissing IV. Thursday Molecular factors and mechanisms related to apoptosis and NOS signalling in exercise, disuse and aging Topics: assessment techniques, effects of training, disuse and aging, blood-flow restricted exercise Speaker: Ulrik Frandsen Neuronal and muscular aspects in the old and very old effects of aging vs exercise Topics: physiological alterations with aging, MU size and number, collateral reinnvervation, MU firing frequency, muscle morphology and fiber type in the old and very old, effects of training, effects of inactivity vs. life-long training Speakers: Per Aagaard, Jesper L. Andersen Muscle and neuronal function in the elderly in relation to sarcopenia, disuse, hospitalization and exercise Topics: applicable assessment methods, physiological alterations with disuse, effects of training, evaluation and training of the hospitalized elderly Speakers: Charlotte Suetta, Paolo Caserotti Muscle function in clinical patients effects of exercise Topics: myalgia, stroke patients, hip replacement surgery, chronic pulmonary disease, arthrosis, chronic kidney disease, heart disease, effects of training Speakers: Lars L. Andersen

4 V. Friday Neuromuscular aspects related to non-contact ACL injury in elite female athletes Topics: neuromuscular hamstring function, soccer, team handball, effects of neuromotor/strength training Speaker: Mette Zebis Effects of exercise intensity on muscle growth, influence of nutrional supplementation influence on cell signalling events and longitudinal training effects Topics: hypertrophy, low vs high load exercise, mrna, growth factors, transcriptional factors, aging Speakers: Lars Holm Rehabilitation and prevention of muscle-tendon injury by use of exercise molecular and biomechanical aspects Topics: tendinopathy, tendon microdialysis techniques, tendon biopsy sampling, muscle strain injury, rehabilitation, effects of eccentric muscle-tendon loading Speakers: Henning Langberg, Per Aagaard Course Participants own projects Presentations by participants VI. Saturday Participants own projects Presentations by participants, continued Concluding remarks Per Aagaard Invited Speakers Per Aagaard, Professor PhD, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark Fawzi Kadi, Associate Professor MD PhD, School of Health and Medical Sciences, Division of Sport Sciences, Örebro University, Örebro, Sweden Peter Magnusson, Professor PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Hospital, University of Copenhagen, Denmark Jesper L. Andersen, Associate Professor PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Peter Schjerling, Associate Professor PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Charlotte Suetta, MD PhD, Dept Clinical Physiology and Nuclear Medicine & Center of Healthy Aging, Bispebjerg Kristian Vissing, Associate Professor PhD, Department of Sports Science, University of Aarhus Paolo Caserotti, Associate Professor PhD, Institute of National Health (NIH), Bethesda, Washington, USA & Institute of Sports Science and Clinical Biomechanics, Abigail Mackey-Sennels, Senior Researcher PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Markus Gruber, Professor PhD, Department Sport Science, University of Konstanz, Fach 30, Konstanz, Germany [continued next page]

5 Lars Holm, Senior Researcher PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Jesper Lundbye-Jensen, Senior Researcher PhD, Department of Neuroscience & Pharmacology, University of Copenhagen, Copenhagen Katja Heinemeier, Senior Researcher PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Niels Ørtenblad, Associate Professor PhD, Institute of Sports Science and Clinical Biomechanics, Ulrik Frandsen, Associate Professor PhD, Institute of Sports Science and Clinical Biomechanics, Henning Langberg, Associate Professor PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Jens Bojsen-Møller, Professor PhD, Norge Idrætshøjskole (NIH), Oslo, Norge Mette Zebis, PhD, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark Mads Kongsgaard, Senior Researcher PhD, Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Lars L. Andersen, Associate Professor PhD, National Research Centre for the Working Environment (NFA), Copenhagen ACCOMODATION in Odense Selected Hotels and Hostels: Comfort Hotel Windsor Radisson Blue Cab-Inn Odense Odense Hostel (DanHostel City -Vandrehjem) Hotel Domir Odense Ydes Hotel More Hotels and Hostels can be found at the following link

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