GenScript Antibody Services

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1 GenScript Antibody Services Scientific experts, innovative technologies, proven performance We specialize in custom antibody production to empower your research Custom Polyclonal Antibody Production Custom Monoclonal Antibody Production Phospho-Specific Antibody Production Antibody Drug Development

2 GenScript Technology Advantage Op muman gen TM design tool, powered by the industry s most advanced an gen design algorithm, designs superior pep des for an body produc on ImmPlus TM an gen modi ca on technology to break immune tolerance to produce surrogate an bodies Proprietary adjuvant technology to elicit stronger and faster cellular immune reponse and longer immune stability, making produc on of high- ter, high-affinity an bodies possible GANP transgenic mice are licensed from Transgenic Inc. and allow for produc on of high-affinity and high-speci city an bodies through overexpression of Germinal Center Associated Nuclear Protein (GANP) At GenScript, our team of scientists possess unparalleled expertise in custom antibody and drug development. Since 2004, we have provided over 13,000 high quality custom antibodies to clients all over the world. Our streamlined process takes you from gene sequence to antigen design and synthesis, antibody development, assay development, and beyond. Partnering with GenScript ensures that you will always benefit from: Advanced technologies Rigorous quality control Scientific experts offering support and advice throughout your project Fast turnaround time State-of-the-art animal facility (AAALAC International accredited and OLAW assured animal facility) Flexible customization options Competitive pricing

3 polyclonal antibody Standard polyclonal antibody Custom Polyclonal Custom Monoclonal MonoExpress TM monoclonal antibody Customized monoclonal antibody MamPower TM recombinant monoclonal antibody FragPower TM antibody production Phospho-specific polyclonal antibody Phospho-specific monoclonal antibody Phospho- Specific Drug Development DNA immunization Ab development Anti-idiotype Ab production Premium hybridoma development HT Gene to Ab Ab library & phage display the limits of technology to save more lives by providing early drug discovery and development. Founded in 2002, GenScript has grown partner in advancing and transforming biology research to make your research easy.

4 Blot IHC ELISA IP/ChIP Sandwich ELISA IF/Flow cytometry Functional Assay Linear epitope Folded epitope Polyclonal Ab Monoclonal Ab Recombinant Others Recombinant Others MonoExpress TM No No Standard packages No Custom packages Custom packages What to expect from our process Submit protein sequence program QC by WB/ELISA Delivery of final product ELISA Western blot IHC IP FACS Others

5 Express 45-day Ab service packages Fast pab Services Antibody Packages offer an unprecedented guarantee to our customers ensuring delivery of 1-5 mg of purified antibody with a final ELISA titer of at least 1:64,000. With our Silver and Gold packages delivering more pab for your target protein, you can stretch your research dollars, further increasing your opportunity for success by 2-3 times over other commercial pabs. Delivery comes at record-breaking speed in only 45 days (from order to delivery), faster than any other vendors and at the competitive price for 2 custom antibodies. All of this comes with a free-if-fail guarantee that eliminates the risk to you. This package cannot be replicated by others. Package Features Premium SC1676 Recombinant protein** 1 Ab generated against protein immunogen protein guaranteed 1-5 mg purified Ab Gold SC Abs generated against 3 individual epitopes success >95% 3 affinity-purified Abs (1-5 mg each) Silver SC Abs generated against 2 individual epitopes success >85% 2 affinity-purified Abs (1-5 mg each) Basic SC Ab generated against 1 epitope Thousands of successful cases 1-5 mg purified Ab *Silver and Gold packages only apply to a single target protein sequence. Cannot be combined from different protein targets. **Protein may be full length or a protein fragment 10 KD depending on which is more likely to generate a successful antibody.

6 Standard pab Services* Complete Affinity-Puri ed Pep de Supplied pab Package (Rabbit) SC1031 Customer Provides Delivery Time An gen sequence mg affinity-puri ed an bodies (ELISA ter of 1:64,000) 5 mg unconjugated pep de 1-2 ml pre-immune serum Cer cate of Analysis report, MS and HPLC reports Total: 13 weeks Pep de Supplied pab Package (Rabbit) SC1015 Customer Provides Delivery Time An gen sequence ml an sera from 2 rabbits (ELISA ter of 1:64,000) 5 mg unconjugated pep de 1-2 ml pre-immune serum Cer cate of Analysis report, MS and HPLC reports Total: 16 weeks Protein A-Puri ed Pep de Supplied pab Package (Rabbit) SC1045 Customer Provides Delivery Time An gen sequence mg protein A-puri ed an bodies (ELISA ter of 1:64,000) 5 mg unconjugated pep de 1-2 ml pre-immune serum Cer cate of Analysis report, MS and HPLC reports Total: 13 weeks Phospho-Speci c pab Package (Rabbit) SC1044 Customer Provides Delivery Time An gen sequence 1-30 mg phospho-speci c an bodies from 2 rabbits (ELISA ter of 1:64,000) 5 mg phospho-pep de 5 mg non-phospho-pep de 1-2 ml pre-immune serum Cer cate of Analysis report, MS and HPLC reports Total: 17 weeks *Produc on from mice, rats, chickens, or goats/sheep also available

7 Fast mab Services MonoExpress custom monoclonal ant body production allow you to choose either peptide or recombinant protein as antigen. You supply the protein sequence and we will deliver your specific hybridoma supernatants within 45 days of antigen preparation. MonoExpress Silver and Bronze custom monoclonal antibody production packages use peptide antigen and each starts with peptide antigen design using our proprietary OptimumAntigen design tool, followed by peptide synthesis, mouse or rat immunization, all the way to final specific hybridoma screening and selection. MonoExpress Gold and Basic packages use protein antigen: the Gold package includes protein antigen production, while the Basic package requires you to provide your own protein antigen. In addition to the delivery of specific, both packages also deliver 2 mg affinity-purified antibody with Western Blot guarantee. Package Guarantees Recombinant protein to MonoExpress Premium SC1711 TM At least one clone works for customer's First: 10 supernatants for ** Final: Up to 5, 2 mg purified Ab, 200 µg immunogen protein 6 Ab-producing Gold SC hybridoma cell lines immunogen 4 Ab-producing Silver SC1661 immunogen Customer s protein Up to 5 Ab-producing 4 supernatants (5 ml/clone) 2 hybridoma cell lines 2-5 Ab-producing Basic SC supernatants (5 ml/clone) 4 hybridoma cell lines immunogen Bronze SC supernatants (5 ml/clone) First: Up to 5 supernatants immunogen and ELISA Final: Up to 5, 2 mg purified Ab 2-5 Ab-producing Phospho-specific SC1659 * Up to 5 Ab-producing First: 2-5 supernatants, * with non-phosphofinal: 2-5, 2 mg purified Ab <15aa and 90% purity **

8 VH H Service Phase I TM protocol Animals: Balb/c mice, C57BL6 mice or rats Number of animals Test bleed report or samples Phase II Cell fusion and Screening immunogen screening Parental supernatant report or samples sent to client. Client may select best candidates to enter Phase III Phase III Subcloning, Screening, and Expansion Hybridoma cell lines MamPower TM Features Timeline When to use this service Guaranteed service QC data 8-12 weeks When you need hassle-free, high quality, mammalian protein expression FragPower TM Fragment Expression Amount Purity Timeline V V scfv E.coli 10 mg 90% 7 weeks V V HH /V H E.coli 10 mg 90% 7 weeks V Fab Insect 3 mg 90% 10 weeks QC data

9 Packages You Provide and Guarantees Timeline Polyclonal Phospho-specific SC1044 sequence Final 1-2 ml of pre-immune serum ELISA results** Guarantees 17 weeks Monoclonal MonoExpress TM Phospho-specific (mouse or rat) SC1659 sequence First 2-5 supernatants Final 2-5 hybridoma cell lines 2 mg purified Ab ELISA results** First Delivery weeks Guarantees 2-5 and at least 1 Custom pab or mab phospho-specific package Your own physical Varies with custom package design Varies with custom design Nature EMBO PNAS J. of Am Med Assoc Mol Biol Cell Cancer Research Journal of Cell Science Journal of Bio Chemistry Plant Cell Nature Commun

10 Drug Development Hybridoma Development Sequencing in vitro Assay and Screening /Protein Characteriza on Chimeric Genera on Produc on b y Drug Development Humaniza on Stable Cell Line Affinity Matura on Transient Expression Epitope Mapping in vivo Efficacy and Safety This one-stop service package starts with Antigen Production and Hybridoma Development, and is followed by Antibody Sequencing, which provides the basis for antibody optimization. In addition, Chimeric Antibody Generation offers a fast and inexpensive approach for generating therapeutic antibodies, and Antibody Humanization provides a more advanced way of reducing immunogenicity of antibodies to human antigens. Affinity Maturation gives your antibody desired affinity to achieve its function. Epitope Mapping not only provides important information on the nature of your antibody, but also facilitates patent application to protect it. Properties of your antibody and antigen such as affinity and thermostability can be measured through Antibody/Protein Characterization. Biological functions and activities of your antibody and antigen can be assessed via in vitro Assay and Screening as well as an in vivo Efficacy and Safety study. At the end, Antibody Transient Expression, Antibody Stable Cell Line and Antibody Production produce sufficient amount of antibodies for your research and development project. Drug Development Therapeu c Hybridoma Engineering Bio-Assay Animal Model Bio-process An gen produc on Immuniza on in vivo transfec on Cell fusion Hybridoma screening Hybridoma stabiliza on mab sequencing Chimeriza on Humaniza on Affinity matura on Epitope mapping Phage/yeast display FASEBA screening Characteriza on BioAnalysis Camelid single domain an body Stable cell line for assay development ADCC CDC Tumor cell line pro ling HTRF assay development in vivo efficacy evalua on Tumour models In ammatory disease models Pharmacokine cs Toxicity Biomarker Transient expression Stable expression Cell line development Process development Scale-up

11 DNA Immunization Services for Antibody Development DNA Immunization Technology is a powerful tool to aid in custom antibody production against membrane proteins, other problematic antigens, as well as early DNA vaccine development studies. This innovative technique allows antigen production in vivo, bypassing the need to produce and purify protein antigen in vitro. Whether your antigen is a membrane protein or other challenging antigen, such as a toxic, unstable or insoluble protein that is difficult to express or purify, our experienced team of scientists will utilize a fully customizable DNA immunization approach to meet your specific research goals. You provide the DNA sequence GenScript DNA Step Timeline Gene Synthesis & 2-3 weeks In vitro DNA expression in vivo 6-10 weeks gene gun Test bleed by ELISA Primary screening by whole cell based ELISA Customer can ecaluate supernatants and Cell Fusion & Screening 4-6 weeks Subcloning, Expansion according to the evalutaion result from the customer, then expanded & frozen Based on project ELISA results Services QC Hybridoma cell lines, supernatants and 10

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