Bilaga 2: Sammanställning av SFO-miljöernas svar på vissa frågor Förord Uppföljningen av de strategiska forskningsområdena (SFO) omfattar 43 miljöer. Denna bilaga innehåller miljöernas enkätsvar på vissa centrala frågor avseende verksamheten 2013, sorterade enligt de önskemål regeringen angav i uppdragen. Miljöernas fullständiga enkätsvar måste läsas för att få en rättvisande bild av vad som har skett inom miljöerna eftersom de har valt att lägga tonvikt på olika frågor. Följande sammanställning ger en övergripande totalbild av vad som skett inom satsningen, men är inget underlag för analys av enskilda miljöer. Nedan följer en beskrivning av vilka frågor regeringen lämnat i uppdraget. Under varje fråga specificeras vilka enkätfrågor myndigheterna har valt ut för att ge ett kortfattat svar på regeringens frågor. Regeringens fråga: Beskriv de samlade resurser som avsatts för det strategiska området. Svar enkätfråga C3a och C3b Regeringens fråga: Beskriv de huvudsakliga prioriteringar som under året. Svar enkätfråga Q1 Regeringens fråga: Beskriv den verksamhet som bedrivits under året Svar enkätfråga Q2 Regeringens fråga: Beskriv de väsentliga resultat som uppnåtts under året. Svar enkätfråga Q3 1 (175)
Innehåll Bilaga 2: Sammanställning av SFO-miljöernas svar på vissa frågor... 1 Förord... 1 1. Strategiskt forskningsområde: Cancer... 5 1.1. StratCan - Center for Integrated Cancer Studies at Karolinska Institutet - an environment for translational cancer research... 5 1.2. BioCARE - Biomarkers in Cancer Medicine Improving Health Care, Education and Innovation... 9 1.3. The U-Can Comprehensive Cancer Consortium... 11 2. Strategiskt forskningsområde: Diabetes... 15 2.1 Translational Program in Diabetes Research, Education and Care... 15 2.2 EXODIAB Excellence of Diabetes Research in Sweden... 18 3. Strategiskt forskningsområde: Effekter på naturresurser, ekosystemtjänster och biologisk mångfald... 23 3.1 BECC - Biodiversity and Ecosystem services in a Changing Climate... 23 3.2 A multiscale, cross-disciplinary approach to the study of climate change effect on ecosystem services and biodiversity... 26 4. Strategiskt forskningsområde: Energi... 29 4.1 Chalmers Energy Initiative... 29 4.2 Bio4Energy... 36 4.3 StandUp... 43 5. Strategiskt forskningsområde: Epidemiologi... 47 5.1 Epidemiology: from mechanism to prevention, from surveillance to safety... 47 5.2 Epidemiology for Health (EpiHealth): for Innovation and Excellence in Open-Access, Basic-Translational and Applied Epidemiological Research... 52 6. Strategiskt forskningsområde: E-vetenskap... 57 6.1. Swedish e-science Research Centre... 57 6.2 essence An escience Collaboration... 61 7. Strategiskt forskningsområde: Havsmiljöforskning... 65 7.1 Ecosystem Approach to the Baltic Sea... 65 7.2 Ecosystem dynamics in the Baltic Sea in a changing climate perspective ECOCHANGE 69 8. Strategiskt forskningsområde: Hållbart nyttjande av naturresurser... 75 8.1 Sustainable use of mineral resources securing the future... 75 2 (175)
8.2 Forests and other plants... 82 9. Strategiskt forskningsområde: IT och mobil kommunikation, inklusive framtida lösningar för kommunikation och ledningssystem... 89 9.1 ICT The Next Generation... 89 9.2 elliit the Linköping Lund Initiative on IT and Mobile Coummunication... 92 10. Strategiskt forskningsomtråde: Klimatmodeller... 95 10.1 ModElling the Regional and Global Eart system MERGE... 95 10.2 Modelling initiative of the Bert Bolin Centre for Climate Change... 98 11. Strategiskt forskningsområde: Materialvetenskap, inklusive funktionella material... 101 11.1 Strategic Initiative Materials Science... 101 11.2 International Interdisciplinary Materials Science Laboratory for Advanced Functional Materials... 105 12. Strategiskt forskningsområde: Molekylär biovetenskap... 109 12.1 Science for Life Laboratory a national resource center for high-throughput molecular bioscience... 109 12.2 SciLifeLab, Uppsala (Center for genomic and proteomic medicine)... 112 13. Strategiskt forskningsområde: Nanovetenskap och nanoteknik... 115 13.1 Chalmers Nano-initiative... 115 13.2 The nanometer Structure Consortium at Lund University... 118 14. Strategiskt forskningsområde: Neurovetenskap, inklusive hjärnans och nervsystemets sjukdomar... 121 14.1 Cognitive and Motor functions in Health and Disease during the Lifespan... 121 14.2 Multidisciplinary research focused on Parkinson s disease MultiPark... 124 15. Strategiskt forskningsområde: Politiskt viktiga geografiska regioner... 129 15.1 The Middle East in the Contemporary World... 129 15.2 Uppsala Russian Research Center... 133 16. Strategiskt forskningsområde: Produktionsteknik... 139 16.1 Sustainable Production Initiative... 139 16.2 XPRESS Initiative for excellence in production research... 142 17. Strategiskt forskningsområde: Stamceller och regenerativ medicin... 145 17.1 Center for Regenerativ Medicine... 145 17.2 National initiative on Stem Cells for Regenerativ Therapy... 148 18. Strategiskt forskningsområde: Säkerhet och krisberedskap... 151 18.1 Security Link... 151 18.2 Natural-Disaster Science... 154 3 (175)
19. Strategiskt forskningsområde: Transportforskning... 157 19.1 Chalmers Sustainable Transport Initiative... 157 19.2 TrenOp, Transport Research Environment with Novel Perspectives... 161 20. Strategiskt forskningsområde: Vårdforskning... 165 20.1 Toward Person-Centered Care in Long-term Illness: A Research Core Center... 165 20.2 Bridging Research and Practice for Better Health: The Comprehensive Care Science Centre 169 20.3 U-CARE: Better Psychosocial Care at a Lower Cost? Evidence-based assessment and Psychosocial Care via Internet, a Swedish Example... 172 4 (175)
1. Strategiskt forskningsområde: Cancer Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 25 40 70 70 70 Avsättning till infrastruktur 9 11 14 14 14 Budget efter avsättning 16 29 56 56 56 1.1. StratCan - Center for Integrated Cancer Studies at Karolinska Institutet - an environment for translational cancer research Huvudsökande: Karolinska Institutet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 19 817 000 Personell 6 448 000 Co funding from main applicant higher education institution 6 463 450 Running costs 6 172 000 Co-funding from-co-applicant higher education institution High cost Equipment - Funding from collaborating research institutes Infrastructure running costs - Funding from other collaborators Other Costs 2 810 000 Other external funding 83 952 833 Totalt: 15 430 000 Totalt: 110 233 283 5 (175)
Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution...n.b an exhaustive list is not required. Other external funding includes funding from: - Cancerfonden: 26% of other external funding - Vetenskapsrådet: 16% of other external funding - EU: 14% of other external funding - Stockholms Läns Landsting: 12% of other external funding - AZ/KI: 6% of other external funding - ALF-medel: 5% of other external funding Please state the main priorities within the environment in 2013. (Question Q1) The main priorities of the Strategic Research Programme in Cancer (StratCan) have during 2013 been in line with the overall aim of the environment to integrate basic and clinical cancer research and to promote the translation of findings into clinical practice. StratCan aims to expand the existing strength in cancer biology at Karolinska Institutet (KI), by supporting high impact research projects, promising young researchers and required infrastructure. StratCan has established a research environment and meeting point for the most competitive cancer research at KI, bringing together research groups and research centers (the three Thematic Theme Centers and the two Linné centers within cancer research) spread over many different departments and three geographical locations. The main priorities during 2013 have been: 1. Research excellence Investing in human capital by research grants for young researchers and innovative research, as well as in strategic recruitment of world leading scientists to KI. 2. Strategic alliances Establishing strategic alliances with international cancer research environments of the highest quality, and with industrial partners. Consolidating and strengthening the alliance with Stockholm County Council and the Regional Cancer Center (RCC). 3. Infrastructure efforts Supporting StratCan initiated infrastructure efforts that facilitate high quality basic research and the translation of findings into clinical practice. Complementing these efforts with new initiatives to tie together basic and clinical cancer research. Initiate large-scale comprehensive genomic characterization of primary tumor material. 4. Education Supporting the education of a new generation of cancer researchers as well as researchers that combine clinical practice with research. 5. Innovation and outreach Increasing innovation potential, industrial collaboration and visibility. 6. National strategic forum Developing the StratCan initiated national strategic forum devoted to strengthening of cancer research and improved cancer prevention and treatment, together with the other two Swedish strategic research programs in cancer (U-CAN and BioCare). Please describe the major activities within the environment in 2013. (Question Q2) "1.During 2013 StratCan continued development and strengthening of research through support of the human capital, especially young researchers, by grant distribution (sought in competition and selected by external review). Two new 4-year Research Associate positions have been filled and two 1-year Blue Sky grants (for innovative high risk research projects) were granted. StratCan has during 2013 continued to be actively 6 (175)
involved in efforts towards strategic recruitment of world leading scientists to KI (Randall Johnson from the University of Cambridge was successfully recruited in 2012). 2. StratCan intensified the international collaboration and KI, as represented by StratCan, signed a "sister institution agreement" with MD Anderson Cancer Center in May 2013. MD Anderson Cancer Center is a topranked comprehensive cancer center in the United States. The signing ceremony was held at KI accompanied by a mini-symposium with prominent international speakers. KI/StratCan participated in the SINF (Sister Institution Network Fund) 2013 grant announcement for collaborative grants. StratCan s partnership with RCC (Regional Cancer Center Stockholm-Gotland) has been developed further by the joint recruitment of Prof. Per Ljungman as the coordinator for biobank and quality registers (clinical annotation and follow-up) and for RCC research activities. Active collaboration with Stockholm County Council has been pursued during 2013 with a main focus on questions regarding the development of a standardized biobanking structure, serving both the clinic and research. 3. The previous infrastructure commitments of StratCan, i.e. support to the Phase I Clinical Trial Unit, Establishment of a Preclinical Cancer Test Facility (advanced imaging) and support for a mouse pathologist (Raoul Kuiper), have been continued during 2013. These efforts constitute a central aspect towards strengthening of the research environment. A key new effort financed by StratCan in 2013 in collaboration with SciLife Lab, was the successful pilot project in tumor profiling (ClinSeq) aimed at establishing a routine pipeline from collection to genetic profiling of primary tumor samples. 4. During 2013 StratCan committed to support the National Research School in Clinical Cancer Research (NatiOn) with means to cover the expenses for research time for 10 clinicians pursuing their PhD. The annual StratCan Summer School was held June 10-14 at Sandhamn Seglarhotel in Stockholm with world-leading cancer researchers as invited lecturers and discussion leaders on the topic of Targeted Cancer Therapies. 5. StratCan started collaboration with KI Innovations AB in 2013 to achieve a more focused industry/innovation agenda. An innovation manager is recruited early 2014, with the task to identify projects within StratCan with commercialization potential. Additionally several joint events are planned for 2014, such as an innovation workshop by StratCan-KI Innovations AB in Spring 2014, a seminar series with industry/entrepreneurial focus and joint sessions at the 3rd Swedish Cancer meeting in September 2014. These efforts will strengthen the ongoing collaboration between several individual research groups and companies, give rise to new collaborations and allow for a more coordinated approach towards interaction with the industrial sector. 6. The 2nd Swedish Cancer research meeting was successfully held in Uppsala Nov 2013 (300 participants) together with UCAN and BioCare, as a continuation of the StratCan initiated national assembly of cancer researchers. Planning has begun for the 3rd Swedish Cancer research meeting, which will be held as a joint (including also RCC as an organizer) larger international meeting in September 2014 at Aula Medica, KI. One important goal of this meeting is to provide information about the present status of cancer research and an outlook on the most important research tasks for the future." Please describe the major results within the environment in 2013. (Question Q3) "1. StratCan grants have become established means of support for young researchers and innovative research ideas and 2013 two new 4-year research-associate and two Blue Sky grants were approved. StratCan principal investigators have during 2013 produced 139 high impact publications. See also the description of the most important scientific findings 2013 (D1a). 2. StratCan s contacts with MD Anderson Cancer center (MDACC) resulted in the signing of a Sister Institution agreement between Karolinska Institutet and MDACC, in May 2013. As a result StratCan participated in the 7 (175)
SINF (Sister Institution Network Fund) grant call and successfully had the largest number of collaborative applications among all of MDACC s current 27 Sister Institutions. Three collaborative projects (supported by the institutions involved) were funded, setting a solid ground for strong collaboration between our research institutes. In May 2014 StratCan will participate in the SINF meeting in Seoul Korea, interacting with a global network of cancer institutions seeking collaborative efforts and joint strategies in the field. The collaborative program with German Cancer Research Center (DKFZ) is continuing and presently includes two collaborative projects funded by StratCan. The StratCan-RCC collaboration led to joint recruitment of Per Ljungman as coordinator for biobank and quality registers (clinical annotation and follow-up) and RCC research activities. 3. Previously initiated StratCan infrastructure efforts are essential for the research environment and contribute significantly to the research results presented. The Phase I Clinical Trial Unit, had during 2013 a total of 9 ongoing clinical trials of which 3 were started in 2013. A new successful initiative 2013, in collaboration with the Clinical Genomics Platform at SciLife Lab, was the ClinSeq pilot project led by Henrik Grönberg. ClinSeq evaluates the use of next generation sequencing (NGS) in the clinical diagnosis of cancer and in research (evaluating tumor profiling in breast cancer, colorectal cancer, ovarian cancer, pancreatic cancer and acute myeloid leukemia (AML). This StratCan financed pilot project plans to benchmark towards the molecular diagnostics used today during 2014 and aims to introduce tumor profiling in the first clinical indications during the fall. 4. StratCan organized for the third successive year a successful Interactive Summer School for young scientists, again resulting in an excellent evaluation by the participants. The 2014 Summer School is set on the topic of Cancer Prevention. 5. During 2013 StratCan prioritized innovation potential and outreach, resulting in a two-year agreement with KI Innovations AB for a structured industry/innovation agenda and a StratCan dedicated innovation manager. In addition, collaboration with Narva kommunikationsbyrå resulted in a new graphic profile and led to new strategies for dissemination of results that will be implemented during 2014 (through the new StratCan web page, launched Spring 2014, as well as other channels). 6. The 2nd Swedish Cancer research meeting was successfully held 2013 (300 participants) together with UCAN and BioCare. The 3rd Swedish Cancer research meeting arrangements have been agreed on for a large international meeting in Sept 2014." 8 (175)
1.2. BioCARE - Biomarkers in Cancer Medicine Improving Health Care, Education and Innovation Huvudsökande: Lunds universitet 70% Medsökande: Göteborgs universitet 30% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 16 896 000 Personell 8 100 133 83 732 423 Running costs 6 139 909 Co-funding from-co-applicant higher education institution 50 913 823 Highcost Equipment 73 527 Funding from collaborating research institutes - Infrastructure running costs - Funding from other collaborators - Other Costs 1 983 395 Other external funding 317 989 009 Totalt: 16 296 964 Totalt: 469 531 255 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Our main external sources include: Cancer Research Foundation 20%, The Swedish Research Council 20%, Region Västra Götaland 10%, Childrens Cancer Foundation 5%, European Research Council 5%, Region Skåne 5% Please state the main priorities within the environment in 2011. (Question Q1) " BioCARE is a shared strategic cancer programme at the universities in Lund (LU) and Gothenburg (GU). The overall aim of BioCARE is to promote research of highest international standard and, importantly, to facilitate the translation of acquired knowledge within the cancer biomarker field to the health care sector and Industry and to facilitate the development of personalized cancer medicine. The main priorities for 2013 were: Support of ongoing and new projects with a strong clinical translational edge (BioCARE Translational Projects). Continued support of the BioCARE Research School with biannual retreats and Advanced Seminars to foster new research contacts and collaborations within and between our two universities and university hospitals Recruitment of international top scientists to our cancer centres. Continued support to young promising scientists to facilitate their scientific independence. Support of scientific meetings with cancer biomarker focus. Support for further development of the Sahlgrenska Cancer Center and Lund University Cancer Centre including infrastructural support." 9 (175)
Please describe the major activities within the environment in 2013. (Question Q2) "The main BioCARE activities in 2013 have been: Support to and organization of scientific meetings including BioCARE Research School Retreats, Advanced Seminars and the 2nd joint BioCARE, StratCan and U-Can Cancer Research Meeting in Uppsala. Extended support to BioCARE translational projects. Support to young promising scientists. Continued support of PhD positions. Increased collaboration with and support of translational projects within the health care sector and formalized collaborations with the Regional Cancer Centres (RCC-Syd and RCC-Väst). Promotion of contacts with big pharma and biotech companies to facilitate translational efforts by recruiting an innovation manager. Consolidation of inter-strategic research programme contacts with StratCan and U-Can, the two other cancer programmes in Sweden." Please describe the major results within the environment in 2013. (Question Q3) "The main results obtained during 2013 were: Physical establishment of Lund University Cancer Centre at Medicon Village including 230+ scientists and stateof-the-art equipment. Expansion and further development of the Sahlgrenska Cancer Center in Gothenburg. Identification, characterization and implementation of new diagnostic, prognostic and therapeutic biomarkers in cancer with impact on the health care sector. Specifically, one of the BioCARE-supported projects has generated a drug candidate that has now entered a clinical phase I study. Successful new recruitments of young as well as established top scientists. Continued support to young scientists. Further support to infrastructure for studying cancer mechanisms and novel treatment paradigms in animal models." 10 (175)
1.3. The U-Can Comprehensive Cancer Consortium Huvudsökande: Uppsala universitet 50% Medsökande: Umeå universitet 40%, Stockholms universitet 5%, Kungliga Tekniska Högskolan 5% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 19 600 000 Personell 10 000 000 4 100 000 Running costs 10 300 000 Co-funding from-co-applicant higher education institution 1 000 000 High cost Equipment 840 000 Funding from collaborating research institutes - Infrastructure running costs 560 000 Funding from other collaborators 2 680 000 Other Costs 2 000 000 Other external funding - Totalt: 23 700 000 Totalt: 27 380 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution... N.B an exhaustive list is not required. NOT APPLICABLE Please state the main priorities within the environment in 2013. (Question Q1) " 1) To become an international leader in terms of high-quality longitudinal biobanking of certain cancers. In accordance with the aims of the research initiative proposed in the original application, resources are allocated to create a novel and standardized framework for structured collection of blood, tissues, imagery and patient data in cancer care. This framework, supported by U-CAN, is now running successfully and the collaboration between Uppsala University and Akademiska Hospital and between Umeå University and Norrlands University Hospital is well established. During 2013 U-CAN has allocated additional resources to ensure prompt and efficient collection and processing of patient samples and information. The U-CAN material, including information about every patient, is now ready to be used in cancer research in order to improve diagnosis, treatment and ultimately outcome. 2) To be the hub for competitive translational and clinical cancer research. The value of biobanks is strongly linked to the depth of information on included patients. Biomaterials with detailed patient information are the top priority of academia and pharmaceutical industries, to allow rapid identification of cases of interest for further research and clinical trials. To accomplish a structured database is challenging in cancer biobanking as cancer patients are handled in many different ways and in several different clinics and hospitals. U-CAN has, during 2013, intensified the work with the technical, legal and organizational 11 (175)
aspects of integrating clinical records systems, the cancer quality registers, Laboratory Information Management Systems and a new database of easily-searchable longitudinal information. In particular, U-CAN has during 2013 assisted with additional resources for the local healthcare authorities in Uppsala to specify, procure and implement a next-generation decision support system for cancer care according to joint specifications by academia, industry, and healthcare. 3) To enhance collaboration between academia and industry. U-CAN has during 2013 continued the process of establishing a network of Life Science companies that may be interested in a collaborative research platform and other interactions with U-CAN researchers in terms of collaborative research contracts, regulation of intellectual property rights, publications and the handling of samples and data. Understanding the needs of pharmaceutical companies with regards to structured detailed data collection in cancer care has been a priority. Please describe the major activities within the environment in 2013. (Question Q2) " 1) To become an international leader in terms of high-quality longitudinal biobanking of certain cancers. The overall goal for U-CAN is the establishment of a well-functioning cancer biobank infrastructure. During 2013 U-CAN has intensified the work of standardised reporting forms in radiology and pathology and U-CAN has continued to support the efforts by Uppsala Biobank to create an automated and centralised sample handling procedure and storage facility at Akademiska Hospital. U-CAN has led and supported the successful process of reaching a formal agreement between Uppsala University and Akademiska Hospital concerning how the real-time database for cancer care will be managed and to settle the conditions under which the collected clinical information can be used by researchers at universities and Life science companies. U-CAN has successfully continued the work to include new cancer diagnoses with the addition of breast cancer during 2013. 2) To be the hub for competitive translational and clinical cancer research For the collection and storage of patient-related information, Akademiska Hospital has, in close collaboration with U-CAN, started the implementation process for the real-time database that will function as a decision support system for cancer care. This real-time database for cancer care will easily and safely register more structured information relevant for research than is currently recorded in even the most developed quality registries; information which is necessary for translational cancer research and essential for clinical research and trials. At the same time, this system will be a valuable tool in cancer care. To further strengthen the research organisation within U-CAN, a local research board has been established in Uppsala and Umeå. This board is designed to guarantee strong, relevant and effective scientific production using the collected material and clinical competence at the participating universities. A special focus has been to enable young, promising scientists the possibility to explore and utilise the U-CAN material. 3) To enhance collaboration between academia and industry During 2013, U-CAN and UU Innovation has further strengthened the collaborations with local and international Life Science companies with the aim of running research projects that are of interest to both companies and academia. Furthermore, focus group meetings, co-organized with the research-based pharmaceutical industry in Sweden (LIF), with pharmaceutical companies in the cancer field were held during 2013 to identify specific requirements for the newly established real-time databases in cancer care." Please describe the major results within the environment in 2013. (Question Q3) " 1) To become an international leader in terms of high-quality longitudinal biobanking of certain cancers. The original U-CAN collection covers colorectal cancer, prostate cancer, haematological malignancies and brain tumours. Since then, scientists and clinicians with interests in gynecological cancers joined U-CAN in January 2012 as they see value in structured biobanking and potential for scientific collaboration. As of March 2013, the 12 (175)
diagnosis group of neuroendocrine tumours began collection of blood and tissue samples according to U-CAN routines and due to the well-functioning U-CAN infrastructure breast cancer joined U-CAN in September 2013. Up to the end of 2013, 5639 patients had been included at an annual inclusion rate of nearly 1500 patients. To date, the U-CAN collection has amassed blood and/or tissue samples from 1563 colorectal cancer patients, 1921 prostate cancer patients, 1111 patients with brain tumours, 234 gynecological cancer patients, 620 leukaemia and lymphoma patients, 94 patients with neuroendocrine tumours and 96 breast cancer patients. During 2013 U-CAN has allocated additional resources across each of the cancer disciplines and initiated steps towards the inclusion of the other county councils within the Uppsala/Örebro and Umeå health care regions. Falu Hospital joined as the first external county council of the U-CAN collaboration in 2012, and as a result of U- CANs efforts hospitals in Gävle and Karlstad will be included in the collaboration as of the beginning of 2014. Furthermore, the U-CAN diagnosis group for haematological malignancies has received a research grant from the Uppsala/Örebro Regional Research Council. This grant will be used for a project based on the regional collaboration within U-CAN and includes the county councils of Uppsala, Dalarna, Gävleborg, Södermanland and Värmland. 2) To be the hub for competitive translational and clinical cancer research. U-CAN has initiated several large research studies during 2013 and from 2014 U-CAN can function as a national and international hub for competitive translational and clinical cancer research. Researchers from Uppsala University, Umeå University, KTH and Stockholm University have an extensive collaboration ongoing with the aim to improve outcome, e.g. to determine why some tumours respond to treatment whereas others are resistant, and to explore the concept of tumor stem cells. The U-CAN colorectal diagnosis group has started a large scale biomarker discovery project targeting colorectal cancer for the prediction of recurrence risk and response to therapy. This project is performed in collaboration with the Swedish companies Olink AB and ExScale AB. The U-CAN brain tumour diagnosis group has also started a study using the U-CAN material in order to investigate if certain polymorphisms and molecular markers in genotype-phenotype correlations are associated with prognosis and treatment outcome. Furthermore, brain tumour researchers affiliated with U- CAN won a competitive grant from AstraZeneca to use patient-derived cell cultures in drug discovery. The newly formed U-CAN breast cancer diagnosis group has started collaboration with the South Sweden Cancerome Analysis Network - Breast (SCAN-B). SCAN-B is a multicenter collaboration between hospitals in Malmö, Lund, Helsingborg, Växjö, Halmstad, Kristianstad and Karlskrona who strive to improve survival and quality of life for breast cancer patients through the introduction of gene expression and genomic tumour profiling in the clinical routine. Further, an EU-sponsored, genomics-based clinical trial of individualized breast cancer vaccines (MERIT) included Uppsala University as a partner because of the structured collection infrastructure available through U-CAN. Stockholm University has intensified the development of a highthroughput RNAi knock-out technology during 2013 and the RNAi assay is now ready to be used in different U- CAN projects. 3) To enhance collaboration between academia and industry. The strategic collaboration with Life science companies with the aim of running projects that is of interest to both companies and academia has intensified during 2013. Meetings are continuously organized with industry representatives to ensure that the U-CAN activities meet industry partners needs for future clinical trials and drug development in oncology. These meetings have achieved new collaborations with Swedish and foreign companies. U-CAN representatives have also discussed the possibilities of future collaborations with Pfizer, Roche, Novartis and Celgene. Industry requirements concerning real-time databases have been collected for haematological malignancies and colorectal cancers. A structured process for industry access to such information has been negotiated and agreed between Uppsala University and Akademiska Hospital." 13 (175)
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2. Strategiskt forskningsområde: Diabetes Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 25 40 70 70 70 Avsättning till infrastruktur 9 11 14 14 14 Budget efter avsättning 16 29 56 56 56 2.1 Translational Program in Diabetes Research, Education and Care Huvudsökande: Karolinska Institutet 85% Medsökande Umeå universitet 15% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 28 309 000 Personell 15 422 000 Co funding from main applicant higher education institution 4 400 000 Running costs 5 753 000 Co-funding from-co-applicant higher education institution - High cost Equipment - Funding from collaborating research institutes 6 100 000 Infrastructure running costs - Funding from other collaborators 17 880 000 Other Costs 4 831 000 Other external funding 86 359 000 Totalt: 26 006 000 Totalt: 143 048 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Other external funding includes: - funding from public agencies (VR, ca 20 %; SSF, ca 2 %), - funding from private foundations (Wallenberg Foundation, ca 15 %; Family Erling Persson foundation ca 25 %; Novo Nordisk Foundation ca 7 %; other private foundations, both national and international, ca 6 %) - and funding from EU (European Research Council 15 % and EU framework programmes, ca 8 %). - Funding from other collaborators include funding from the Stockholm county council (ALF funding) ca 55 % and funding from private companies 45 %. 15 (175)
Please state the main priorities within the environment in 2013. (Question Q1) The overall goal of the Strategic Research Programme in Diabetes at Karolinska Institutet (SRP Diabetes) is to improve both prevention and treatment of diabetes by forming an internationally competitive, integrated and interdisciplinary research environment in the diabetes field which should be translational, i.e. to couple basic research with the clinic. The programme should cultivate substantial expertise and unique technical resources that form a natural contact point for international collaborations and attracting excellent researchers and thus to be rich in collaboration, communication and scientific exchange. The priorities from 2012 have been maintained with special focus on: Further integration between the two partner universities Karolinska Institutet and Umeå University by expanding number of collaborative projects and joint meetings. Further strengthen clinical research within the programme through special grants. Further develop the established research infrastructures in the programme designed to support both clinical and experimental research in the metabolism and diabetes field. Supporting innovation processes both within the programme by recruiting external expertise and on a national level through development of an application for the VINNOVA call Strategic Innovation Areas (SIO). Please describe the major activities within the environment in 2013. (Question Q2) "Integration between the research groups: Several different forums for interactions between the researchers have been organized including group leader meetings, different seminar series, an internal retreat and an international symposium with outreach activities beyond the program. To support collaborative projects, funding is directly provided to the group leaders for the support of post-doctoral fellows or technical staff where collaboration between experimental scientists and clinicians is especially encouraged. To better integrate Karolinska Institutet and Umeå University, a mini-symposium was arranged this past year at Umeå University for all of the PIs in the programme. Supporting younger and mid-stage independent researchers: The Assistant Professors and Associate Professors (docent) recruited into this program have been supported with funds, access to the research infrastructures, and participation in the senior group leader activities. Strengthening clinical research in diabetes: Through an open call and external evaluation, four talented clinical researchers in diabetology have been awarded research grants enabling these medical doctors to perform clinical research on a half-time basis. The research node at Umeå University has been strengthened by the recent affiliation of Professor Tommy Olsson and his research group at The University Hospital of Umeå into the programme. To further strengthen clinical research, SRP Diabetes has also developed a collaboration with the 4D type 2 diabetes project (a Karolinska Institutet Stockholm County Council joint clinical research project) to set up a pilot project to establish a prospective biobank for collection of samples from pre-diabetic and type 2 diabetic persons identified through the primary health care system. Research infrastructures: Further development and utilization of the established facilities has been achieved through increased recruitment of technical staff and expertise within the facilities, as well as procurement of new instrumentation. Many of the research infrastructures are too expensive to be developed by single research groups. Innovation support: To support innovation processes within the programme, a dedicated Innovation Manager has been hired. Furthermore an Innovation Advisory Board (IAB) has been formed, with membership reflecting expertise from small biotech startups to large pharmaceutical companies. On a national level, SRP Diabetes (the SFO at Karolinska Institutet) has together with the SFO Diabetes Program in Lund (EXODIAB) and other Swedish stakeholders formed a national strategic innovation and research agenda in diabetes with funding from VINNOVA. Together with another innovation agenda (Swedish Life Science, SILS), these two agendas/groups of stakeholders have prepared an application for the VINNOVA call Strategic Innovation Areas, SIO, which will be submitted in March 2014." 16 (175)
Please describe the major results within the environment in 2013. (Question Q3) "Integration between the research groups: Integration between the 26 different research groups involved in SRP Diabetes has been successful as evidenced by several new collaborative and translational research projects that also include newly recruited researchers to the programme. Integration between research groups is also facilitated through the internal retreat and the international symposium. Both of these activities were especially successful forums with record attendance of students, post-doctoral fellows and active researchers working within the diabetes field, as well as in closely aligned areas of science. Research infrastructures: Utilization of the unique infrastructures developed and supported by SRP Diabetes has increased within the past year, indicating the continued importance of these facilities within SRP Diabetes researchers in the diabetes and metabolism field. Novel analytical tools have also been successfully developed within the facilities, including tools in physiology, bioinformatics, epigenomics and imaging. Selected new research results and projects: Internationally recognized discoveries from SRP Diabetes researchers include novel insights on mechanism by which weight loss surgery alters DNA methylation and improves glucose metabolism in skeletal muscle. Several novel regulators and mechanisms of insulin release in the pancreas have also been described, highlighting new entry-points into future diabetes treatment. Studies of both the size and capacity of the insulin secreting pancreas and how this may be altered due to a change in demand for insulin in the body have been conducted utilizing an in vivo imaging model developed by researchers in the program. SRP Diabetes researchers have also contributed to a better understanding of vascular complications observed in diabetes patients through involvement in a large international human genetics consortium. Through this effort, evidence to supports the practice of treating diabetic dyslipidemia by targeting triglyceride levels rather than cholesterol has been put forward. Pathological mechanisms behind the development of diabetic complications, such as ulcers, have been explored within SRP diabetes, which have led to innovative treatments strategies. Together with a biotech company, the first renal cell implantation has been performed on patients with kidney disease and type 2 diabetes giving new hope to treatment of diabetic complications. Innovation: Two collaborations have been initiated with a Swedish and a European company to develop products based on research developed within the SRP Diabetes at Karolinska Institutet. Two patent applications have been filed and several projects are under evaluation for patenting. Interactions with society: Several outreach activities have been conducted through communication with the media (television, radio and newspaper) covering the recent discoveries made by SRP Diabetes researchers." 17 (175)
2.2 EXODIAB Excellence of Diabetes Research in Sweden Huvudsökande: Lunds universitet 70% Medsökande: Uppsala universitet 30% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 28 160 000 Personell 11 827 920 38 975 139 Running costs 1 712 657 Co-funding from-co-applicant higher education institution 31 200 361 High cost Equipment 6 075 364 Funding from collaborating research institutes 0 Infrastructure running costs 6 413 227 Funding from other collaborators 10 405 905 Other costs 2 844 795 Other external funding 116 421 390 Totalt: 28 873 963 Totalt: 225 162 795 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Our by far largest financial support is given by the Swedish Research Council (Vetenskapsrådet), representing approximately 45% of the total. EU funding for several projects stands for approximately 15% of the total. Another large funding agency is the American National Institute of Health, approximately 10% of the total. Please state the main priorities within the environment in 2013. (Question Q1) "EXODIAB EXCELLENCE OF DIABETES RESEARCH IN SWEDEN Exodiab is a joint research initiative in the diabetes area combining internationally competitive diabetes research at Lund and Uppsala universities. In collaboration with industrial partners we develop novel approaches and tools for early risk assessment, prevention and individualized treatment of diabetes. RESEARCH PRIORITIES IN 2013 A) Our infrastructure the Human Tissue Lab continues to serve as the basis for numerous research and innovation projects and remains a main priority in 2013; B) Recruitment of new diabetics to the two clinical cohorts ANDIS/ANDIU (All New Diabetics in Scania and All New Diabetics in Uppsala) has been prioritized also in 2013; C) Performing excellent and translational research, expanding our fundamental understanding of diabetes, thereby generating top-class candidate projects for commercial development; D) Large joint research applications have been filed; E) Efforts to create an arena where metabolic clinical investigations can take place have been prioritized. 18 (175)
INNOVATION PRIORITIES IN 2013 In 2013 Exodiab prioritized to F) secure funding for the establishment of a company called Diabridge; G) continue negotiations with selected Big Pharma and Life Science; H) arrange an IDEA Summit meeting where European actors from academia and commercial companies met to discuss future innovation endeavours in the field of diabetes; I) develop a PhD course in Innovation, "Research Innovation and Value Creation in the Life Science Area". EDUCATION PRIORITIES IN 2013 Exodiab has prioritized to J) create a meeting arena for those with an interest in Bioinformatics at Lund University and to K) arrange a seminar series in bioinformatics; Furthermore, in 2013 we have continued to L) strive for the launch of an MD/PhD program to secure future clinical research and translation. Finally, in 2013 we have tried to M) recruit an internationally recognized bioinformatician." Please describe the major activities within the environment in 2013. (Question Q2) "RESEARCH ACTIVITIES FOR EXODIAB IN 2013 Our multi-disciplinary research is a successful strategy Our research groups in Lund and Uppsala join forces in unravelling the genetic and environmental factors contributing to diabetes and in finding new ways for treatment, disease control and prevention. The multidisciplinary scientific approach taken has proven very successful. The Human Tissue Lab provides tissue and data to our researchers. The two clinical cohorts ANDIS and ANDIU continue to recruit new diabetics that are subsequently followed closely. We have in 2013 worked with improving the sub-classification of diabetes and anticipate that this will help us develop individualized treatment strategies. Planning for excellent research in the years to come We foresee that more clinical studies will be performed in the future and want to strengthen the translation of our basic research findings into clinical practice. A major activity in 2013 has been to create an arena where clinical studies relating to diabetes and obesity can be performed. Furthermore, several large joint research applications have been filed to try to secure continued research support for our large biological infrastructures. INNOVATION ACTIVITIES FOR EXODIAB IN 2013 Securing funding for the Diabridge company The Diabridge is envisioned to serve as the natural commercialization platform for the research within Exodiab, but also for other Swedish researchers. In 2013 we have intensified our efforts in securing governmental funding for starting the company. Negotiations with Big Pharma Numerous interactive meetings have been held in 2013 between Exodiab and representatives for Big Pharma and Life Science companies. Exodiab has both initiated and continued negotiations with different industrial partners. Setting a visionary diabetes innovation agenda In 2013 we arranged IDEA Summit with participants from European academia and Life Science companies. Presentations and panel discussions were held with the ambition of directing future diabetes innovation activities into new directions hopefully leading to more fruitful interactions between academia and industry. Developing a PhD course in Innovation To better prepare our future researchers for innovation and entrepreneurship we have together with Lennart Gisselsson (Lund University Innovation System) and Maria Andersson (Faculty of Engineering, Lund University) developed a new PhD course in Innovation. This course will enable Life Science researchers to identify the commercial potential in their research results. Topics such as immaterial property rights, interactions with 19 (175)
society and how to find funding for commercialization of Life Science projects will be addressed at the new PhD course. EDUCATION ACTIVITIES FOR EXODIAB IN 2013 Bioinformatics At Lund University the Pufendorf Institute stimulates cross-disciplinary research of long-term strategic importance. In 2013 Exodiab together with other Strategic Research Areas and Linnaeus centres at Lund University filed an application to become an Advanced Study Group at the Pufendorf Institute. We were granted funding for our proposed activities to be held in 2013-2014, mainly open seminars. In 2013 we have created a meeting arena for persons at Lund University with an interest in bioinformatics. Participants come from three different faculties. Filing of an application for the recruitment of an internationally renowned guest professor in bioinformatics has been done in 2013. Can the launch of the new national medical training help us in having an input in an MD/PhD program? Exodiab strives to have an impact on future clinical translation and clinical research. Implementing changes in an existing educational system takes time and Exodiab tries to use the current momentum created during the national revision of the medical training." Please describe the major results within the environment in 2013. (Question Q3) "RESEARCH RESULTS FOR EXODIAB IN 2013 Exodiab has published a vast amount of scientific publications in the field of diabetes, more than 340 articles, all contributing to improving our understanding of diabetes. The multi-disciplinary work performed is reflected in the varied journals our researchers publish in. As previously reported our biological infrastructure, the Exodiab Human Tissue Lab, is a crucial asset to Exodiab researchers. To date more than 190 pancreases have been donated to the national Human Tissue Lab, whereof 28 come from diagnosed diabetics. These tissues are carefully investigated and the results are shared and made available to Exodiab researchers. In addition to pancreases, the Human Tissue Lab also includes other tissues relevant for diabetes research, such as fat, muscle, liver, kidney and blood vessels. Since the beginning in 2008 more than 10 000 newly diagnosed diabetics have been recruited to the clinical cohorts ANDIS and ANDIU. We already can see that a new map of diabetes subgroups needs to be drawn, based on analysis of genetic markers and biomarkers. In the summer of 2013 one published article attracted special attention by press worldwide, exemplified by an article in the New York Times. The investigation of DNA methylation in fat cells, before and after a period of intensified exercise, showed that methylation of genes were altered following exercise. The identification of distinct genes that were regulated by methylation is likely able to explain the mechanism whereby exercise reduces the risk of diabetes and obesity. INNOVATION RESULTS FOR EXODIAB IN 2013 Forming the Diabridge company: In 2013 efforts to find funding for the company has been prioritized. Exodiab has taken the initiative with the Strategic Research Area at Karolinska Institute/Umeå University and AstraZeneca as partners to develop an agenda for innovation. The pilot project was granted by VINNOVA and a follow-up expression of interest has been filed in 2013. A feasibility study has been undertaken to investigate the current premises for the establishment of Diabridge. Identifying innovation projects: Since the start of the Innovation Office 36 potential projects/ideas have been evaluated. At the end of 2013 six projects were active and were found at different stages of development. Licensing deal: A licensing deal with an industry partner has been negotiated in 2013. Enhancing academic and industrial communication and mutual understanding: An IDEA Summit meeting was 20 (175)
held at Lund University in 2013. Academia and Life Science companies met to discuss selected topics such as how academia and industry can work together to address key questions concerning diabetes. At IDEA Summit presentations by invited international speakers were followed by panel discussions using moderators. Participants from national as well as international academia, Big Pharma and Life Science companies attended the meeting. PhD course in innovation: Curriculum for a PhD course in innovation, "Research Innovation and Value Creation in the Life Science Area", has been established. The course has been approved at Lund University as a 2,5 credit course and will run for the first time during spring 2014. EDUCATION RESULTS FOR EXODIAB IN 2013 Pufendorf Advanced Study Group: In 2013 we filed and were granted funding from Lund University to start and run a Pufendorf Advanced Study Group in Bioinformatics entitled Bioinformatics - From sequences to systems biology and beyond. Following a planning meeting with the 14 members of the study group, an open kick-off meeting was arranged. In all more than 100 persons at Lund University have expressed their interest in bioinformatics and between 20-60 persons have attended the four open seminars arranged at the Pufendorf Institute in 2013. Guest professor application: An application to recruit an internationally recognized bioinformatician as guest professor at Lund University has been filed. Continued discussions concerning an MD/PhD-program: Medical training in Sweden is currently undergoing national revisions. In 2013 Exodiab has discussed the possibility of implementing an MD/PhD program with the new medical training to enable future clinical studies in Sweden. Furthermore, we need to ensure that we train researchers with a medical background to complement existing PhD programs with students having other backgrounds. We need researchers with a clinical background, as well as researchers with experimental backgrounds, to know what the needs of patients are and successfully translate scientific findings to patients and society." 21 (175)
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3. Strategiskt forskningsområde: Effekter på naturresurser, ekosystemtjänster och biologisk mångfald Huvudansvarig myndighet: Samrådande myndighet: Formas Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 25 35 50 50 50 Avsättning till infrastruktur 5 7 10 10 10 Budget efter avsättning 20 28 40 40 40 3.1 BECC - Biodiversity and Ecosystem services in a Changing Climate Huvudsökande: Lunds universitet 78% Medsökande: Göteborgs universitet 22% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 24 137 000 Personell 18 142 089 Co funding from main applicant higher education institution 30 433 872 Running costs 2 050 683 Co-funding from-co-applicant higher education institution 6 150 000 High cost Equipment 182 511 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 0 Other costs 8 339 670 Other external funding 81 150 831 Totalt: 28 714 953 Totalt: 141 871 703 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. Other external funding: Largest financiers year 2013 (%) LU UGOT The Swedish Research Council (VR) 34% 0% Swedish Research Council, Formas 29% 36% Swedish International Deevlopment Agency (SIDA) 0% 38% The European Union (EU) 12% 0% Other financiers 25% 26% 23 (175)
Please state the main priorities within the environment in 2013. (Question Q1) "Biodiversity and Ecosystem Services in a Changing Climate (BECC) is a research programme within the Strategic Research Area (SRA) Effekter på naturresurser, ekosystemtjänster och biologisk mångfald. Our vision is to create a world-leading interdisciplinary research programme on climate- ecosystem-biodiversity relationships at multiple scales, bringing together ecological modelling with empirical studies and linking this with policy and governance for the sustainable management of ecosystems and biodiversity in a rapidly changing world. To this end the main priorities during 2012 have been: * To increase long-term scientific interactions between empiricists and modellers as well as between social and natural scientists, by establishing so called action groups explicitly focusing on research development and synthesis. These cross-disciplinary groups are led by young researchers, forming the next generation of research leaders in BECC. * To recruit young researchers to projects spanning across departments and disciplines, and within the framework of a research school develop a curriculum for our PhD students that includes interdisciplinary education and synthesis. * To facilitate research by identifying needs for and supporting research infrastructure in the areas of climate and biodiversity research, including making use of new research facilities at Lund University. * To systematically develop our interactions with stakeholders, both to inform us about their needs for research as a basis for decision-making, and as a channel for the dissemination of results. BECC increasingly focuses on synthesising research results relating to pressing societal issues. Since BECC is a large and growing research environment, comprising 140 researchers and 80 PhD-students across disciplines, an important priority during the past year has been the further development of a strong and effective management and support to researchers and efficient outreach." Please describe the major activities within the environment in 2013. (Question Q2) "BECC has significantly developed and consolidated as a research environment since its creation four years ago. BECC research remains on a scientifically high standard, resulting in publications in highly ranked international journals, frequent citations and the attraction of large grants from national and international research councils. This year the board initiated an internal review, identifying ways to strengthen cross-disciplinary research and policy relevance. The review was discussed within BECC and with the scientific advisory board. Our stakeholder reference group (jointly with the MERGE-SRA), was used to identify areas for joint research and synthesis. Mechanisms set up to promote cross-disciplinary research have resulted in significant research grants and collaborative projects with stakeholders. An internationally leading scientist in molecular spectroscopy of organic material and mineral surfaces, Professor Per Persson, has been recruited into the BECC environment. Several young researchers have been recruited as senior lecturers and researchers and are now establishing promising independent careers. The environment has been further strengthened by several new PhD-studentships with a cross-disciplinary focus. The Skogaryd Research Catchment established by researchers at Earth Sciences, University of Gothenburg (UGOT), was selected as one of the key terrestrial and limnic stations in the Swedish Infrastructure for Ecosystem Science (SITES), a key national infrastructure. In a successful, competitive bid, Sweden and LU was selected to host the Carbon Portal, a central facility of the Integrated Carbon Observation System, ICOS, a European infrastructure for ecosystem and atmospheric greenhouse gas research and monitoring. BECC has invested in making research relevant and used for policy. BECC researchers are active as scientific advisors and experts, and in synthesis activities in close collaboration with stakeholders. Initiatives like the 24 (175)
BECC annual meeting theme on the green economy aim to promote relevance and outreach by making stakeholder concerns and policy agendas better known to the BECC researcher community." Please describe the major results within the environment in 2013. (Question Q3) "Some highlights from the BECC environment during 2013 are: In findings of high interest in global carbon cycle research, BECC researchers have demonstrated that carbon in the soil of a boreal forest largely originates from roots and root associated microorganisms, and that carbon losses from agricultural and grasslands soils can be strongly influenced by the properties of the soil food web. BECC has developed ecosystem modelling and related methodology. The dynamic vegetation model LPJ-GUESS has been expanded to include managed vegetation, to target additional ecological interactions, and to evaluate adaptation options for forest management under climate change. By combining modelling, monitoring and experiments, to examine synergies between climate change and lake brownification in detail, it was found that biological community responses to global change are determined by properties of the food-web. These results provide an important framework for predicting future aquatic ecosystems and their ecosystem service provisioning. Arctic ecology studies have demonstrated important interactions between climate change and altered land use (reindeer grazing) in their effects on vegetation in the Scandian mountains as driven by climate change and their combination. Regional climate modelling, ecosystem modelling and palaeoecological analysis of past land use and land cover combined using an innovative statistical approach has for the first time discriminated the relative influences of past human land use and natural vegetation dynamics on land cover-climate interactions in Northern Europe over past centuries to millennia. In a seminal book, political scientists analysed climate and ecosystem governance in relation to international institutions as well as in the national context. This research provides new insights into how climate change creates new forms of social order and the role of the State for climate and environmental governance." 25 (175)
3.2 A multiscale, cross-disciplinary approach to the study of climate change effect on ecosystem services and biodiversity Huvudsökande: Stockholms universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 16 000 000 Personell 17 323 000 7 168 000 Running costs 1 790 000 Co-funding from-co-applicant higher education institution - High cost Equipment 349 000 Funding from collaborating research institutes 241 000 Infrastructure running costs 9 138 000 Funding from other collaborators 0 Other costs 578 000 Other external funding 2 683 000 Totalt: 29 178 000 Totalt: 26 092 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Other funding represents grants from Formas (60 %), VR (20 %), SKB (10 %), NEO (5 %) and Lamm (5 %). Please state the main priorities within the environment in 2013. (Question Q1) The main priorities in 2013 were similar to those stated for 2012, with the addition that we have made the operational planning for deliveries from Ekoklim 2014-15. A major delivery will be a special issue of the journal Ambio, and the planning of this has been an important priority 2013. An important priority has also been to strengthen the network at SU among different strategic research environments. We have particularly focused on developing the collaboration with the Bolin Centre for Climate Research. Please describe the major activities within the environment in 2013. (Question Q2) The main activity during 2013 has been research within the four clusters of Ekoklim, and planning for finalizing the deliveries from the program, now when we approach the last of the five years of the program period. To communicate climate change effects on ecosystems, as well as to inspire additional cross-disciplinary interactions, Ekoklim organized a successful open public seminar series during spring 2013 "Stockholm Talks on Ecology and Climate", featuring researchers from Ekoklim and invited high profile international scientists. To communicate the scientific output of Ekoklim, we have initiated work on a special issue in Ambio, which will be published in February 2015. The issue will comprise 14 scientific papers representing different aspects of Ekoklim research, and an additional synopsis paper which will summarize these papers in a broader Ekoklim 26 (175)
context. We have also further developed the master courses Ecology and Climate, and Landscape Ecology, and promoted interactions among PhD-students in Ekoklim. Please describe the major results within the environment in 2011. (Question Q3) Ekoklim has made important contributions to development of Strategic Environmental Assessment linked to hydro-climatic and water resource monitoring, and identified a number of indicators that can and should be continuously monitored for appropriate water and food security governance. On larger spatiotemporal scales, a suit of Ekoklim studies of the Norrström drainage basin, as well as of different parts of Sweden and the world have addressed the relations of land-water-use developments and climate-environmental-water resource changes in the landscape. By synthesis of these and related earlier results for different world regions, significant historic hydro-climatic shifts were identified, driven by human water use for food and energy production. For the densely populated coastal regions across the world, tipping points were identified for seawater intrusion in coastal groundwater under rising sea level and/or inland hydro-climatic changes in conjunction with increasing human use of coastal groundwater. With regard to species long-term survival in changing landscapes, connectivity between species communities is crucial. Ekoklim has shown that there has been a reduction in human and livestock dispersal vectors in the Norrström study region during the 20th century, but increasing numbers of motor vehicles and wild herbivores may have the potential to replace some of the lost functional connectivity. Ekoklim has contributed to the international, high-profile topic of extinction debt, i.e. the time-lag in the effects of changing habitats on biodiversity, by identifying different mechanisms of how an extinction debt arises. Furthermore, Ekoklim studies show that effects of climate and land use change are interdependent, and interact with local habitat conditions, suggesting that understanding interactions between climate and land use is necessary to reliably predict future population viability and to optimize conservation. Ekoklim contributed in an international collaboration paper published in Science on ecosystem effects of large carnivores, suggesting that large carnivore control of herbivores might increase the level of carbon storage in plants in some ecosystems, and large carnivores also contribute ecosystem services such as tourism revenue and top-down control of smaller carnivores and herbivores. Changes such as climate change, urbanisation and economic instability, do not only impact on ecology, biodiversity and ecosystem services, but also creates large challenges for policy makers and societal planners. Ekoklim studies of adaptive governance and transformations provide novel knowledge of the institutional and organisational aspects of governance of ecosystem services under changing ecological and social conditions. A key insight from the international perspective is the emerging importance of anticipatory governance in building policy responses to managing ecosystems under climate change. Ekoklim participates in governance processes and foster stakeholder participation in our research through dialogue with actors in the Mälardalen region and concerning integrated coastal zone management in different sites in Sweden. 27 (175)
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4. Strategiskt forskningsområde: Energi Huvudansvarig myndighet: Samrådande myndighet: Energimyndigheten Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 50 100 160 160 160 Avsättning till infrastruktur 0 0 0 0 0 Budget efter avsättning 50 100 160 160 160 4.1 Chalmers Energy Initiative Huvudsökande: Chalmers Tekniska Högskola 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 58 336 000 Personell 36 026 000 Co funding from main applicant higher education institution 29 168 000 Running costs 13 690 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 440 000 Funding from collaborating research institutes 5 636 000 Infrastructure running costs 366 000 Funding from other collaborators 0 Other costs 13 539 000 Other external funding 0 Totalt: 64 061 000 Totalt: 93 140 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.. N.B an exhaustive list is not required. Chalmers has chosen not to report the amount of external funding above because of the difficulty to produce figures that accurately reflect the funding situation in the strategic research area (SRA). This has several reasons, for example: (i) a fairly large portion of the researchers are involved in more than one AoA and their external grants might partly or entirely be used for projects in other areas, making it difficult to determine to what extent the external funding should be attributed to one or the other area, (ii) some researchers are involved in research within the area, but not directly associated with the AoA, and therefore do not report their results or external funding here. Also, (iii) external funding received by researchers involved in the area at our partner universities is difficult to determine and to include in a relevant way. During 2013, Chalmers has investigated and considered several different models for reporting external funding to these environments, both by internal analysis and by conferring with some of the other involved Swedish 29 (175)
universities. We have recently decided on a model for reporting external funding in a satisfactory and authentic way and will use this for reporting for the entire period of 2010-2013 during the self-evaluation in spring of 2014. Please state the main priorities within the environment in 2013. (Question Q1) "This questionnaire deals with Chalmers Energy Initiative (CEI), which receives strategic governmental funding. Chalmers Energy Initiative is divided into four research areas: Energy Combines, Large-scale renewable electricity generation and grid integration, Electricity propulsion systems and hybrid vehicles, and Technology Impact Assessment. However, strong energy related research at Chalmers is broader than CEI. Chalmers Energy Area of Advance (AoA) covers the broader energy context and CEI energy research areas represent around 60 % of the total activities within Energy AoA. It is, however, important to note that CEI in many respects acts like a catalyst to the whole Energy AoA. CEI creates, by its nature, closer internal connections and open up new and promising interdisciplinary opportunities. This is true for research, but also for education and innovation. Priority settings within CEI are made in conjunction with the overall priority settings in Energy AoA They are also done at different levels and in different forums. One important managing task is to harmonize our priorities and to create synergy effects with the different sources of funding. The governmental strategic funding is very valuable for our long-term strategic development. Our approach to the long-term possibilities given is to strengthen our position in terms of new, high quality, senior staff members, creating a vivid interdisciplinary environment attractive to post-docs, and PhD students, and not to forget courage to invest for the future. This means that the basic priority settings done at the start of CEI, described in detail in our proposal, still is valid for 2013 and the years before. The courage to apply a long-term approach to our decisions relies on the belief of future funding, which in turn goes hand in hand with proving excellence in research, education and knowledge transfer. The priorities in our research activities are as for previous years in accordance with our proposal. Specific activities and results, and hence our more detailed priorities, are presented in our answer to Question Q2 and Q3. Education at bachelor, master and doctoral levels are all highly influenced by research findings. Through CEI research activities we are able to integrate education with research, primarily due to the fact that researchers are almost always also teachers. Examples in education are often taken from on-going research projects. During 2013, we have had strategic agreements with four industrial companies; E.ON (10 MSEK annually), Göteborg Energi (up to 10 MSEK annually depending on proposals), PREEM (approximately 3,5 MSEK annually) and ABB (around 8 MSEK annually). Priorities setting for these collaborations are done in together with the companies in a very lively and fruitful atmosphere. Knowledge transfer is in these collaborations done in two directions, which strengthen both parts. The priorities are, however, in line with the overall agenda for the Energy AoA." Please describe the major activities within the environment in 2013. (Question Q2) "The main activities have been connected to continue the outset program of CEI. In the beginning of the program clear work plans were made for the 5-year period that the program will last. We have continued along the lines initiated and critically assessed the progress in line with how the respective research fields have developed and we have made adjustments where it can help us further materialize on the competence built. As the program now have matured more efforts has been made to increase the output and visibility of the results with strong outreach activities addressing both societal needs, industrial needs and contribute to 30 (175)
establish CEI has an internationally well recognized research environment. By embedding CEI in the Area of Advance concept we have a strong and efficient platform to work on the outreach dimension, and a natural way to take advantage of the advanced and transformative opportunities the AoA offer. Main outreach activities Outreach activities are of major importance to us to reach goals of strengthen the integration of education, research and innovation. Our outreach activities encompass a number of measures that are out-lined below. In our educational efforts we have applied gained new competences and knowledge from the different research fields to influence the educational programs, establish new courses, industry relevant project work and assignment with relevance for industry. We have also been able to offer several new PhD courses, some of which has been given for an international audience, thereby contributing to increased networking. Furthermore, we have performed extensive continued education for the industry through Chalmers Professional Education. As previous years the main initiatives related to knowledge transfer and utilization of research findings are linked to our vast number of relations with industry and society. We cooperate with more than two hundred different stakeholders making knowledge transfer possible in an effective manner. With four of these stakeholders (ABB [new 2013], Göteborg Energi, E.ON, and Preem [renewed 2013]) we work through strategic collaboration agreements. Through these more than two hundred collaborations we also to a large extent develop our own direction of research. During 2013, selected specific new Energy Area of Advance outreach activities were. * Chalmers Energy Conference 2013 The role of Energy Efficiency, The third annual Chalmers Energy Conference that is a new international forum for academia and stakeholders involved in shaping tomorrow s energy system and which we started 2011. The conference was held three days in may 2013. Approximately 150 participants. * In 2013 the second evolving e-book was published. The second e-book is entitled Systems Perspectives on Electromobility and can be read and downloaded from: www.chalmers.se/energy. * International Process Integration Jubilee Conference was held at Chalmers in March 2013 * The IEA workshop within the area of System and Integration Aspects of Biorefinery concepts based Biomassbased Gasification, was held at Chalmers in November 2013. * Numerous talks, and articles of individual researchers available to a broader audience. Collaboration internally, with academia internationally, with research institutes, industries and society is extensive. Not visible, but what makes large impact, is the many exchanges and collaborative links individual researchers have. The environment in CEI and the Area of Advance stimulate collaborations and dissemination. Our interaction with industry is increasing in strength and intensity. We chose this year to highlight one example of knowledge transfer. This example intends to serve as an illustration on initiatives within the environment of CEI. The strategy for knowledge transfer and research utilization in CEI HEV2 (research package nr 2 in Hybrid Electric Vehicles) involves two industrial researchers, Lars Johannesson Mårdh (Assistant Professor Automatic 31 (175)
Control) and Torbjörn Thiringer (Professor Electrical Power Engineering). The industrial researchers work 50% in academia and 50 % in the vehicle industry thereby forming an important bridge between academia and industry by taking active part in industrial development projects. Since industrial development and research projects most often are classified, much of the knowledge transfer and research utilization from the research package HEV2 cannot be publically presented here. However, it is possible to point towards two projects where the two industrial researchers have been instrumental in transferring knowledge and research results from HEV2 to the vehicle industry. The first example is a project where system design tools and software developed in HEV2 was successfully integrated in the Volvo ATR prestudy and development processes and is briefly described in the following link: http://www.chalmers.se/sv/institutioner/s2/nyheter/sidor/the-researchers-who-can-predict-the-future-oftransportation.aspx. The second example is the development of the Volvo V60 Inverter that was awarded with the Volvo Technology Award http://www.chalmers.se/en/departments/ee/news/pages/thiringer-awarded-volvo-cars- Technology-Award.aspx. Besides the use of shared personal resources, researchers from HEV2 have supervised several master thesis projects and have helped to organize workshops for both Volvo Car Cooperation and Volvo ATR. The following statement was given by Henrik Svenningstorp, Director Alternative Vehicle Efficiency Volvo GTT ATR Energy Efficiency & Environment AB Volvo with permission to be used in this report and in Signals and Systems annual report: "The research on methods and software tools for hybrid vehicle energy management at Signals and Systems Chalmers and Viktoria Swedish ICT strengthens AB Volvo s ongoing projects and provides a good example for fruitful collaboration between industry and academia." Main research activities Here we describe our main activities in the research area, where we in addition to executing the outset research plan, paid efforts to constantly increasing our international visibility and recognition, increase collaboration, in particular interdisciplinary collaboration, and attract external funding to further develop our research strengths. The main results will be accounted for under Q3. Energy combine In the energy combine part of the CEI program we address how, thermochemical, chemical and biochemical conversion technologies alone or in different combinations can be used for the production of energy carriers and other products from different biomass sources. We address carbon capture and storage by oxyfuel and chemical looping combustion including material recycling issues. Other conversion technologies include separation technologies such as lignin precipitation, steam explosion to support wood decomposition and fermentation routes to produce biofuels from wood sugars. Process integration and system studies have this year largely focused on the opportunities in co-localizing future biorefineries with existing industries and to identify energy and material efficient biorefinery solutions. We have developed the research area to address research challenges phrased within the framework of the biobased economy, which has enabled us to attract research funding from the FORMAS program in biobased economy, engage ourselves in the development of the SIO in Forestry products and processes. Several internationalization activities took place with external stays in leading research environments together with guest researchers aiming at building up new collaborative links. 32 (175)
Large scale renewable electricity generation and grid integration In large-scale renewable electricity generation we work on modelling the effect of large-scale introduction of wind and solar power on a European level. The research address the interaction with thermal base load production and what are good investment strategies for the future under different environmental targets, considering investments in wind and solar power, new thermal power and transmission capacity. We furthermore, focus our activities on materials for high voltage engineering where we investigate the thermal component of ageing and its influence on electrical treeing parameters and furthermore, we address the challenge to measure electrical conductivity in high voltage systems. Finally, we focused solar cells research activities around the need for increased device performance and lifetime. The industries have shown great interest in our modelling tools and we have cooperation with major utilities (Vattenfall and EON) as well as with Elforsk and with the EC Directorate Joint Research Center of Europe (DG- JRC). Electrical propulsion systems and hybrid vehicles To make electrical hybrid vehicles attractive, the battery technology has to reach higher energy density and the driving range be improved and cost reduced for the vehicles. In this area, we spend efforts in developing sustainable battery technology both improving present Li-ion technology and contributing to a new generation of batteries addressing technology for Na-ion batteries and Li-S batteries. We also direct our research towards energy management strategies for plug-in hydrid vehicles. In parallel inventory LCA scale models are developed for determining the environmental impact. Finally, the aspect on vehicle recycling to minimize loss of scarce metals is investigated. Technology impact assessment We work on mega-challenges addressing (i) climate change and how to pursue a policy which helps us transform the energy sector in time and (ii) the issue of how science is made socially useful and the associated problem of formulating science policy. We constantly develop methodology that should enable us to better and investigate different scenarios and understand these challenges from different systems perspectives. Efforts in developing different methodology for constantly refining environmental impact assessments are also made. Our work in the technology impact assessment is well recognized and politicians and policy makers often ask us for expert opinions." Please describe the major results within the environment in 2013. (Question Q3) "During the year the research has commenced forward at good pace, generated new scientific results and the build up of the CEI program starts to generate results and human capital that will set long-term influence on the energy agenda. We performed a bibliometric analysis showing that the CEI program has led to an significantly increased number of intradisciplinary publications, which is one of the prime targets for CEI since the challenges ahead demand complementary knowledge. Our work show high impact numbers and the result of the effort of educating a new generation of scientists in the energy area now start to pay off. Here we focus on reporting the major research achievements within our four research areas. Energy combine Carbon capture and storage technology focusing on oxyfuels and chemical looping combustion has been performed. Efforts have been made to understand the material recycling and corrosion processes, where we gained important new insights during the year. Accompanying the experimental research, we have also managed to coordinate the generic research between gasification and combustion applications using fluidized bed technology, including expanding and improving our modeling capabilities with the aim to provide tools for reliable design and scale up of fluidized bed systems for combustion and gasification. 33 (175)
During chemical conversion, attention has been put to the improved use of the lignin fraction, where achievements has been made in controlled lignin cracking, showing good efficiency in the process. In addition, experimental equipment has been put up to allow steam pretreatment studies on single fibres. Biochemical conversion activities have focused on process technologies and strain improvement to allow more efficient high gravity fermentations. Development of multi-feeding systems for fermentation significantly improved the efficiency of such processes. Using detailed physiological investigations increased understanding of the cellular traits conveying robustness were reached and could be materialized in metabolic engineering approaches. Process integration and systems has achieved results in integrating systems for algae cultivations and use integrated with existing industries that led to initiation of new projects. Methodological advancements of process integration and systems studies have been made in particular in the perspective of biorefinery systems. Large scale renewable electricity generation and grid integration Working on energy systems modelling the effect of large scale introduction of wind and solar power on a European level we have now reached a modelling package that is one of the most comprehensive in Europe when it comes to the possibility to analyse the European electricity generation system and the role of Sweden and the Nordic countries in the transition of the European energy system under various scenarios up to the year 2050. Regarding high voltage engineering we have developed tools and got insights to how electrical treeing is influenced by thermal stress. The results include a novel diagnostic system for detection of electrical treeing in nontransparent materials by means of partial discharge measurements. We have also identified some novel voltage stabilizers. The morphology of polymer solar cells is important for its performance, during 2013 tools to control morphology of polymer solar cells were developed by use of solvent additives/annealing and mixtures of fullerenes to control the crystal size of the fullerenes phase. This result is very important for the continued development of solar cells. Electrical propulsion systems and hybrid vehicles A major challenge in this area is to develop sustainable battery technology. Using Li-ion technology we have developed a totally revised scheme of battery gas evolution upon heating, leading to better battery safety and improved understanding of the gelation of battery electrolytes directly in the battery. In striving for developing a new generation of batteries, we radically improved the Na-ion batteries and improved the energy capacity in Li-S batteries. In the research on energy management strategies for hybrid electrical vehicles, a concept based on identifying commuter routes and optimizing the discharge rate indicate saving potentials in the range of 6-7 %. Industrial implementation is under way. Furthermore, a framework for simultaneous optimization of powertrain sizing and energy management has been developed using convex optimization and the framework has been applied on a number of examples. Dynamic programming algorithms have been developed for deciding the vehicle speed, gear shifts and power split strategies of hybrid vehicles. This technology can also be used for intelligent cruising in conventional vehicles. Finally, a framework for scalable life cycle inventory models of key electric powertrain components, a PM motor and one model for different types of power electronic converters has been established. Technology impact assessment The key results achieved includes (i) a method for addressing how science is made useful which may be of great value for both academia and policy makers; (ii) detailed analyses of the main policy challenges for realizing the potential of offshore wind power in EU and Sweden respectively; (iii) an in-depth and critical analysis of the 34 (175)
current "affordability" discourse related to German and broader EU Energy Policy (iv) a deeper understanding of the challenge of funding the required investments in technologies that produce electricity from renewable energy sources. Furthermore, methodologies addressing different land use models, energy systems models and models for estimation of the influence of pesticide emissions on human and freshwater toxicity has been developed and applied in different case stories." 35 (175)
4.2 Bio4Energy Huvudsökande: Umeå universitet 44,8% Medsökande: Luleå Tekniska Universitet 36,8%, Sveriges Lantbruksuniversitet 18,4% a. Income of the strategic research environment 2011 (all income, Question C3a) b. Costs of the strategic research environment 2011 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 50 286 000 Personell 28 534 000 14 400 000 Running costs 12 986 000 Co-funding from-co-applicant higher education institution 21 130 000 High cost Equipment 472 000 Funding from collaborating research institutes 5 500 000 Infrastructure running costs 3 869 000 Funding from other collaborators 10 280 000 Other costs 3 870 000 Other external funding 67 217 000 Totalt: 49 731 000 Totalt: 168 813 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Energimyndigheten, EU FP7, VR, Formas, Interreg, Nordic Energy and Stint. A.S.: Due to a delay in recruitment, there is a slight surplus in revenue for the financial year of 2013. This surplus will be erased in 2014 as and when an ongoing recruitment of a senior researcher, a professor to work on the Bio4Energy Thermochemical Platform, will be finalised. Bio4Energy apologises for the delay but can ensure that the gap will be filled. Please state the main priorities within the environment in 2013. (Question Q1) "During 2013 the main priorities in the Bio4Energy research environment were the following: - Perform research and development to provide technology and processes needed to set afoot efficient and sustainable biorefinery and bioenergy operations, dependent mainly on renewable forest-sourced input materials or organic waste. - Publish the result of these efforts in high-ranking peer reviewed scientific journals and, when such results consisted of breakthrough or major developments, turn these into popular communications issued as news releases, newsletters or online articles at www.bio4energy.se with increased efforts put into reaching an international audience. - Take care not only to provide meetings and meeting fora for Bio4Energy members, but also to make sure that each meeting theme and setting was supportive of increased or new collaborations and ideas for innovative 36 (175)
projects which might be carried out in the eventuality that the government's and authorities renew support for Bio4Energy in the years 2015-2020. - Internal communications were emphasised to further consolidate the Bio4Energy research environment by facilitating contacts between its main players, i.e. the Bio4Energy Board, Steering Group, researchers and popular communication agents at the three partner universities in Bio4Energy and also those of our strategic partner SP Processum and Solander Cleantech. - Seek and obtain external funding and increase cooperation and collaboration with industry and research institutes in sectors of interest in Sweden and internationally. - Make a substantial start to the work to devise an two-tier operational strategy for research and development work in Bio4Energy, focusing in a first instant on the years 2015-2020." Please describe the major activities within the environment in 2013. (Question Q2) The major activities in the Bio4Energy research environment were identical to the description under indent "Q1", with a few additions. These additions are not of minor importance, but considered as specific activities that were signaled in the 2012 annual evaluation of Bio4Energy or were research breakthroughs: - Start of the Bio4Energy Graduate School by means of a Programme Conference in March 2013 (See: http://www.bio4energy.se/component/content/article/84-latest-news/675-b4e-students-shine-along-withkeynotes-at-opening-of-b4e-graduate-school-one-wins-price.html). The first course of the Bio4Energy Graduate School, generic to Bio4Energy, was carried out between May and December 2013 (http://www.bio4energy.se/component/content/article/84-latest-news/970-wirlwind-tour-of-northernswedens-biorefinery-pilots-receives-appreciation.html). - State-of-the-art pilot facilities for a type of biomass pre-treatment, torrefaction, which method is designed to allow for easy handling, storage and conversion of woody and other biomass, were inaugurated at Umeå, Sweden, in October 2013 (http://www.bio4energy.se/component/content/article/84-latest-news/936- torrefaction-pilot-facilites-inaugrated-at-umea.html). - Researcher on the Bio4Energy Feedstock Platform helped map the genome of the Norway spruce, a gigantic undertaking which results were finally unveiled in May 2013 (http://www.bio4energy.se/component/content/article/84-latest-news/783-genome-of-norway-sprucemapped.html). - Bio4Energy made a substantial contribution to national or international research and development activities, such as the LTU Green Fuels Centre at Piteå and the Sino-Swedish CHPP - Sustainable Resource Management Initiative (http://www.bio4energy.se/component/content/article/84-latest-news/620-swedish-biofueldevelopment-centre-to-live-on-with-new-owner-coordination-by-b4e-scientist.html; http://www.bio4energy.se/component/content/article/84-latest-news/961-fresh-eco-innovation-funds-tobio4energy-for-chp-demonstration-in-china.html). Moreover, Bio4Energy researchers were instrumental in gaining funding for research and development activities of the LTU Biosyngas Program and the Swedish Centre for Biomass Gasification (SFC) the research at which was deemed by international evaluators to be of the highest international standard. The already leading Bio4Energy Thermochemical Platform thus extended its activities towards further applied topics and had the advantage of conducting this work on site or in close connection with the only dimethyl ether biodiesel (biodme) plant in the world that has sufficiently high capacity to support industrial-scale field testing of e.g., green fuels or chemicals. - Bio4Energy introduced production of cyanobacteria to unique pilot facilities for algae production in northern Sweden. The project will deliver methods for upscaling production of biomass from green algae, of the amino 37 (175)
acid arginine used in sustainable forest soil fertilizer and of fish feed, while ridding spill water in dams at a local energy utility of toxic heavy metals and gaseous carbon dioxide (http://www.bio4energy.se/component/content/article/84-latest-news/943-bio4energy-presents-radflagships-on-algal-residue-biorefinery-pilots-carbon-separation.html). - Bio4Energy researchers made a substantial contribution to a report on biofuels designed to feed into an official Swedish government investigation, unveiled to journalists in December 2013, intended to advise the government on ways in which Sweden might achieve a transport fleet "independent" of fossil fuels by 2030 (http://www.bio4energy.se/component/content/article/84-latest-news/830-one-in-three-cars-in-swedencould-run-on-biofuels-by-2030.html). - Bio4Energy participated in and held a high profile at a range of international and national conferences, such as the European Biomass Conference, the Umeå Renewable Energy Meeting and many others (http://www.bio4energy.se/component/content/article/84-latest-news/789-european-biomass-conferencemeet-bio4energy-researchers-in-copenhagen.html; http://www.bio4energy.se/component/content/article/84- latest-news/639-umea-renewable-energy-meeting-set-to-score-record-number-of-participants-in-fifthyear.html). - On site visits to some of the world leading bioenergy and biorefinery research and development hubs supported through the U.S. government s executive agencies, and the U.S. Department of Energy, were arranged and Bio4Energy played host to world-leading biorefinery researchers from the University of British Columbia and from the International Energy Agency Taskforce on Commercialising Liquid Biofuels. - Activities that led to major research breakthroughs were realised by researchers on the Bio4Energy Feedstock, Pretreatment and Fractionation and Catalysis and Separation Platforms, respectively, while researchers on the Bio4Energy Thermochemical Platform ensured that Sweden maintains the lead in developing sustainable biodme by thermal conversion methods (See e.g.: http://www.bio4energy.se/component/content/article/84-latest-news/1015-researchers-find-handle-withwhich-to-control-wood-growth-density.html.) - Bio4Energy s executive leadership and Communications carried out an exercise to map Bio4Energy s collaborations with industry, research institutes and academy, in that order of significance. Bio4Energy industry-oriented strategic partners were offered to take part of the result, as well as the entire internal academic network (http://www.bio4energy.se/component/content/article/84-latest-news/770-fulfilling-goalsbut-facing-new-ones-industrial-collaborations-discussed-by-researchers-meeting.html). - Bio4Energy Communications work to increase and deepen cooperation between communications departments (or leaders, where such did not exist) at the Bio4Energy member organisations led to several instances of jointly issuing news releases and/or newsletters. Bio4Energy strategic partners SP Processum and Solander Cleantech were approached for this purpose. For a more general purpose of cooperation between organisation, Bio4Energy approached The Energy Initiative at Chalmers University of Technology; Biofuel Region; North Sweden; SP Technical Research Institute of Sweden; Strategic Innovation Areas (SIO) national working group on New Bio-based Materials, Products and Services, as well as; the Swedish Knowledge Centre for Renewable Transportation Fuels and the Brussels-based Bio-based Industries Consortium. Journalists requested visits to Bio4Energy and were received at the hub of the research environment at Umeå University. 38 (175)
Please describe the major results within the environment in 2013. (Question Q3) "Bio4Energy Feedstock Platform - A transporter of the plant hormone auxin was identified, based on which finding Bio4Energy researchers are attempting in experiments to increase the speed of biomass production, and the density of the mass of the stem, in a model plant which genetic makeup is similar to that in trees. (See: http://www.bio4energy.se/component/content/article/84-latest-news/1015-researchers-find-handle-withwhich-to-control-wood-growth-density.html.) - Researchers demonstrated that a "significant" amount of wood lignification takes place only after wood cells have matured (http://www.bio4energy.se/component/content/article/84-latest-news/733-important-step-inwood-formation-demonstrated-by-bio4energy-scientists.html). - Researchers successfully engineered hemicellulose in wood and a patent was filed to secure intellectual property rights for the process. - Some 500 mother trees from the Bio4Energy Traits Database were genotyped. (The database consists of wood property data for 6,000 spruce trees, collected and analysed by Bio4Energy researchers; see the Bio4Energy Newsletter of July 2013). - Platform researchers made a substantial contribution to the Bio4Energy Graduate School and a new civil engineering training programme on bioresources to be offered to undergraduate student from 2014 at Umeå University. Bio4Energy Pretreatment and Fractionation Platform - Bio4Energy contributed no less than 13 chapters to the Handbooks on Green Materials (four volumes in total) by the World Science Publisher, Material and Energy Series. - Breakthrough research results on the way in which not only the root, but also the stem, of the cassava plant could be used to increase food and biofuel supply, both, were achieved and publicised in Sweden and internationally (http://www.bio4energy.se/index.php?start=8). - Researchers designed, constructed, "instrumented" and deployed a new second-generation torrefaction pilot facility in northern Sweden, with a production capacity of 200 kilogrammes per hour. Plans were drawn up for it be followed by a "large-scale" demonstration unit to further scale up the torrefaction technology. The plant will be constructed and started up in 2014, according to researchers (http://www.bio4energy.se/component/content/article/84-latest-news/936-torrefaction-pilot-facilitesinaugrated-at-umea.html). - A new "Bio2Fuels" system and process which could be implemented as a cost-efficient way to produce "carbon negative" liquid biofuel was invented, the scientific results published and a patent sought to secure the process. - A cooperation agreement was signed between Bio4Energy and counterparts in the U.S.A. and China, resulting in the 'Tri-national Bioenergy Feedstock Development Technical Working Group', which should result in collaboration between Bio4Energy, on the one hand, and the U.S. Department of Energy Biomass Programme plus the "NEC" Non-food Biomass of China, on the other, on the characterisation of biomass. - Bio4Energy researchers won funds to carry out the second leg of the Sino-Swedish cooperation programme to produce sustainable biomass for Chinese combined heat and power operations developed with the help of the same Bio4Energy researchers and industrial partners, Swedish and Chinese. A brochure describing the 39 (175)
initiative, CHPP - Sustainable Resource Management Initiative, is available on the Bio4Energy external website (http://www.bio4energy.se/component/content/article/84-latest-news/961-fresh-eco-innovation-funds-tobio4energy-for-chp-demonstration-in-china.html). Bio4Energy Biochemical Platform - Researchers invented and demonstrated ("verified") a newly patented method for making bioethanol from woody cellulose more efficiently, using enzymatic hydrolysis and yeast-based microbial conversion. The patent owner, clean technology firm SEKAB, will be using the invention to reinforce it product range, the lead researcher said (http://www.bio4energy.se/component/content/article/84-latest-news/1009-bio4energyresearchers-behind-new-method-for-cost-efficient-ethanol-making.html). - Large-scale verification of a process to make butyric acid by fermentation and use of bacterial biocatalyst was performed at the biorefinery of Domsjoe Fabriker of Aditya Birla (http://www.bio4energy.se/component/content/article/84-latest-news/531-government-grant-to-funddevelopment-trials-at-ethanol-pilot.html). - Researchers from several Bio4Energy platforms provided input to preparing a new undergraduate training programme at Umeå University for students in Civil Engineering, focusing on "bioresource" technology. The Bio4Energy Graduate School coordinator outlined the progress of the highly successful the training programme for PhD students interested in biorefinery and bioenergy production at several meetings and announced it would be opened to students from outside the Bio4Energy research environment (http://www.bio4energy.se/component/content/article/84-latest-news/1048-bio4energy-to-open-popularpilot-research-course-to-students-from-non-member-organisation.html). - As part of the Sweden-based Forest Chemistry project, Bio4Energy researchers organised a public seminar to describe the activities the industry-academy project to assess the viability of replacing petrochemical products with equivalent products refined from woody feedstock (http://www.bio4energy.se/component/content/article/84-latest-news/706-efficient-hybrid-technology-forbioethanol-production-stirs-interest-of-forest-chemistry-seminar.html). - Two patents were sought to protect inventions realised jointly by Bio4Energy's Biochemical and Feedstock Platforms. Bio4Energy Thermochemical Platform - Platform researchers used Bio4Energy funds to win external funds. In connection to this: 1) the Bio4Energy founding member Luleå University of Technology (LTU) acquired not only the clean-technology company Chemrec s pilot plant for producing a biofuel called dimethyl ether (DME) from a residual product of pulp and paper making, but also the staff working at the pilot facilities, renaming the venture LTU Green Fuels Pilot Plant. A new research programme thus was started in January of 2013, with funding for the first six month totaling KSEK31,500 (http://www.bio4energy.se/component/content/article/84-latest-news/620-swedishbiofuel-development-centre-to-live-on-with-new-owner-coordination-by-b4e-scientist.html). - 2) The researchers went on to submit funding proposals for a long-term research and development programme the LTU Biosyngas Programme which activities were to be centered at the LTU Green Fuels facilities. The Swedish Energy Agency granted the proposal in December 2013, thus ensuring a first programme budget of MSEK158 for a two-and-a-half year period. - The number of people involved in research on thermal conversion increased by more than 20, a figure which includes PhD students and postdoctoral researchers. 40 (175)
- Researchers on the Bio4Energy Thermochemical Platform coordinated investments in new experimental reactors and diagnostic laser equipment, such as drop-tube reactors, PIV system for visualisation and velocity measurement of suspended particles, a size-and-shape analyser and a dual-colour pyrometer with which to measure particle temperature in hot environments/media. The combined experimental resources across the member organisations (the LTU, Umeå University and the Energy Technology Centre at Piteå, mainly) were a very competitive combination, paving the way for high-class experiments and measurements, according to the platform leader. Bio4Energy Catalysis and Separation Platform - In 2013 this world-leading research platform attracted substantial external funding and published 49 peerreviewed scientific articles and sought four patents to protect their inventions. As a result the platform was greatly expanded (an updated member listing will be published in the membership section on http://www.bio4energy.se/research.html). - Four "entirely" new value chains and products portfolios were developed which draw on renewable energy and/or materials. - Achievement of the "highest ever" performance of ultra-thin membranes designed to separate gases or liquids from other gases or liquids. E.g. ultra-thin MFI zeolite membranes were used to separate carbon dioxide and hydrogen at temperatures below zero degrees Celsius. ( MFI is a generic term meaning Mobil five.) - Promising results were obtained as part of the development of a method for blocking defects in MFI membranes, as well as several other related results. For the first time, synthesis gas from the gasification of black liquor was separated out (or purified, Editor s note) using a zeolite membrane (http://www.bio4energy.se/component/content/article/84-latest-news/284-bio4energy-research-results-flowas-shown-by-section-on-latest-publications.html). - Patents have been sought to protect new processes which produce alkyl ethers and "innovative" coatings in which researchers draw on ionic liquid technology, and also in relation to using membranes in industrial processes for commercial use. - Experimental testing was carried out on behalf of Haldor Topsoe A/S and the LTU Green Fuels cluster. - New methods for the fractionation of lignocellulose were developed. Bio4Energy Process Integration Platform - A new senior member of staff joined the platform. - Considerable collaboration with the Swedish Knowledge Centre for Renewable Transportation Fuels, of which Bio4Energy is a member, resulted in several reports for policy makers, such as that on biofuels, commissioned by the Swedish government and mentioned under "Q2" (http://www.bio4energy.se/component/content/article/84-latest-news/830-one-in-three-cars-in-swedencould-run-on-biofuels-by-2030.html). - Researchers were specially invited to present the platform's work on the BeWhere model to counterparts and government official in Brazil. Researchers use the model to investigate and identify locations for and characteristics of cost-efficient biorefinery production sites and facilities for the production of secondgeneration biofuels. - Apart from Bio4Energy researchers' chairing or speaking at major international conferences, one of them was 41 (175)
appointed associate editor of a peer-reviewed scientific journal and secretary of a Swedish government commission, in view of assisting an official investigation, called Beskattning av mikroproducerad el. Bio4Energy Environmental Platform - A concept based on integrated thermal conversion of fermented municipal waste sludge and waste wheat straw was developed with a view to tackle the problem of environmentally noxious waste in the sludge and a foreseen global shortage of the phosphorous chemical, relied on globally as a fertilizing agent. System analysis was performed, indicating that the new conversion concept offered great cost efficiency in terms of phosphorous extraction. - Researchers found an improved way to predict the way in which "critical" ash elements behave in biomass combustion, which should help reactor operators avoid fouling problems. - Cyanobacteria were introduced in existing pilot trials designed to scale up the production of green algae for biomass production which, in turn, provide a societal service by feeding on, and thus removing, chemicals which would otherwise pollute spill water contained in large dams at an Umea energy utility. The cyanobacteria were introduced to produce the amino acid arginine for use as a sustainable forest soil fertilizer (See Bio4Energy's Newsletter of July 2013). Apart from rendering a service to the utility and the Swedish city, by cleaning the waste water of heavy metals and the exhaust gases/evaporation of carbon dioxide, researchers reported to have established cyanobacteria with "high" rates of arginine synthesis. - Researchers focusing on the characterisation and removal of undesirable emissions from biomass combustion established an extraction method based on pressurised liquid extraction to rid woody biomass of organic environmental pollutants, as well as added a quartz reactor to their laboratory to enable more refined studies of thermal combustion on a micro scale (http://www.bio4energy.se/component/content/article/84-latestnews/492-b4e-environmental-lca-biomass-combustion-highligts-of-meeting-with-new-partner-sp.html). - A key scientific article on boron isotope analysis was submitted for publication, describing that a technique for this has been established (http://www.bio4energy.se/component/content/article/84-latest-news/200-borontrials-selective-membranes-a-scrutiny-of-energy-systems-part-of-biorefinery-development.html). - A large scientific research network, extending from Finland in Scandinavia to Australia in the Southern Hemisphere, was established and is in the process of examining multiple aspects of the way in which algal biomass may be produced, along with arginine and fish feed, while cleaning the water in which the algal growth takes place. Thermochemical combustion experiments are ongoing (http://www.bio4energy.se/component/content/article/84-latest-news/943-bio4energy-presents-radflagships-on-algal-residue-biorefinery-pilots-carbon-separation.html). *Overall, 2013 was a year in which Bio4Energy was made more visible on the international arena, thanks to the efforts of the leadership, together with individual Bio4Energy PIs and with an employee of the SP Technical Research Institute of Sweden, as well Bio4Energy Communications. (Several initiatives will be described further on in this report.) Moreover, to increase outreach efforts, Communications started a subscription-based newsletter published in Swedish and in English, plus created an internal website for all the 233 Bio4Energy researchers to use, as well as the Bio4Energy Board, Steering Group and Graduate School." 42 (175)
4.3 StandUp Huvudsökande: Uppsala universitet 36% Medsökande: Kungliga Tekniska Högskolan 48%, Sveriges Lantbruksuniversitet 10%, Luleå Tekniska Universitet 6% a. Income of the strategic research environment 20112 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 52 000 000 Personell 34 502 241 83 952 564 Running costs 8 650 184 Co-funding from-co-applicant higher education institution 104 205 856 High cost Equipment 239 441 Funding from collaborating research institutes 600 000 Infrastructure running costs 2 238 747 Funding from other collaborators 20 333 878 Other costs 12 805 334 Other external funding 364 482 432 Totalt: 58 435 947 Totalt: 625 574 730 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.. N.B an exhaustive list is not required. This is a rough estimate of the sources of Other external funding, since the four universities have somewhat different external funding patterns: Public Research Councils and Agencies: 57% EU-framework programmes: 18% Other International Funding: 2% Private non-profit Foundations/Associations: 10% Private Associations & Companies: 13%; Please state the main priorities within the environment in 2013. (Question Q1) "StandUp for Energy is a large environment guided by a clear vision for the future, namely, to work for a transition of the energy system from fossil fuels to renewable electricity production. The programme has developed its research priorities with the overriding aim of increasing the amount of renewable electricity in the system, handle intermittent electricity sources in the grid and develop electric and hybrid vehicles.working for a long-term alliance - StandUp for Energy beyond 2014 Since its start in 2010, StandUp for Energy has become a well-integrated, productive environment with a lean and efficient management structure. Based on the encouraging results obtained until now, it is the intention of the four universities in the StandUp alliance, KTH, UU, SLU and LTU, to extend the collaboration for another five years, starting on the 1st of January 2015. 43 (175)
To this purpose, a review of the entire programme was carried out during 2013 with respect to the goals stated in the initial proposal. As a result, some changes were made in the allocation of resources to specific projects. The review also paved the way for the formation of a strategic group representing the relevant research areas, namely, renewable electricity production, the electricity grid, electric propulsion vehicles and a holistic view of the energy system. This group will revise the goals of the programme for the next five years in the perspective of ongoing changes in the energy situation in Sweden and the rest of the world, keeping the needs of society at the forefront. The knowledge triangle is to be integrated. The group will report in spring 2014 and its recommendations will form the basis for a new contract between the four universities.other important priorities Widening the scope of the StandUp Academy meetings by making them more public. The bi-annual meetings have opened their doors to external participants, thus profiting from perspectives from industry and public authorities. This contributes insights regarding both technical aspects of the energy system and the societal problems we have to solve. The StandUp Academy has become a major channel for dissemination of research results, collaborations and knowledge transfer. Strengthening and formalizing thematic groups established across university boundaries for discussion and collaboration. Some of these are: StandUp for Energy Systems and StandUp for Wind. The programme has supported formation of a new interdisciplinary group on Electricity Markets, which recently received external funding from the Swedish Energy Agency. The leader of this group is one of our young recruited staff members." Please describe the major activities within the environment in 2013. (Question Q2) "Activities in StandUp for Energy are guided by the need for new technical solutions (responding to the intentions expressed in the call formulated by the Government in 2009): a) for exploiting renewable energy sources to produce electricity and deliver it to the consumer; b) for the inclusion of electric and hybrid vehicles in the energy system; c) for the study of the environmental impact and the conditions for social acceptance of different technologies. StandUp s main endeavor is scientific excellence, but the community is also active in education, outreach activities and public policy. A few selected highlights during 2013: A newsletter has been launched for the community. The community has been involved in answering several government referrals concerning energy and environmental issues, e.g. Sweden - An emission neutral country by 2050. Successful deployment of the first vertical axis marine current turbine in river Dalälven (Söderfors). The unit has delivered power to our onshore measuring station, successfully harnessing the energy in low speed currents. Organization of two StandUp Academy meetings at KTH and UU with attendance of more than 100 persons at each meeting. The meetings also included representatives from industry and agencies. A first StandUp thematic workshop on Electricity Market, Policy and Actor Perspectives. The first Nordic Battery Meeting organized by StandUp in collaboration with SHC (Swedish Hybrid Vehicle Centre). StandUp for Wind has been formalized as a research group studying different aspects of wind energy. StandUp scientists are constantly engaged in diverse activities to focus public attention on energy issues, provide expert advice and spread information about energy research. Among the many public outreach activities in 2013, we can mention: Participation in various public media programmes and debates, for example about the future of the electricity markets (Ekonomiekot lördag, Sep 28), the future of electric vehicles (SVT Agenda, March 24) and the production of today s solar cells (P1 Klotet, April 10). Visits from public personalities interested in energy issues helps bring attention to renewable energy research. During 2013, the US president Obama visited KTH (September 5) and Princess Victoria of Sweden visited the Ångström Laboratory at UU (October 11)." 44 (175)
Please describe the major results within the environment in 2013. (Question Q3) "In an environment consisting of more than 400 researchers and students it is no easy task to choose from the enormous flow of important results. We are particularly pleased with all the collaborative results and successful interactions, both within StandUp and with external partners. Encouraged by this, it is the ambition of the programme to continue the collaboration beyond 2014. Here we present a selection of major results for 2013: A large-scale statistical analysis of the hydro-power potential in Sweden has been carried out, providing a basis for understanding the implications of climate changes and the possibilities for improved production by coordinated management of energy resources. Development of a new methodology that includes soil carbon flow dynamics to quantify possible dynamic climate effects associated with power production from biomass. The results are already used in EU negotiations on solid biofuel regulations. The development of WEC (Wave Energy Converter) technology applies a unique holistic approach to facilitate exploitation of wave energy by society. The largest WECs ever, and the first linear generator WEC without expensive rare-earth magnets, were deployed in 2013. CIGS solar cell devices with the efficiency of 19.8% (close to the world record for thin film solar cells) have been made and deployed in buildings in Frodeparken in Uppsala. Development of algorithms for introducing important functionalities into the electricity grid: 1) to safely and efficiently restore power after power interruptions. Prototypes have been developed with Ericsson and a commercial pilot is being specified. 2) For distributed control of DC grids used for interconnection of large-scale renewables. A proof of concept has been demonstrated in a co-simulation platform using state of the art ABB controllers. The concept is being further developed with ABB. Development of methods for assessing demand response potential in a distribution grid, together with Vattenfall as part of the Smartgrid Gotland Study. The experimental Research Concept Vehicle built at the KTH Transport Labs will be visible on the road in early 2014. A new type of patented permanent magnet motor for electric cars and its control was constructed, tested and patented. New cross-disciplinary electric propulsion projects started in 2013 as a result of StandUp. The projects are in the fields of power converters, Li-ion batteries and electrical road systems. Examples are the SIC Power Centre and new STEM-financed FFI- and Battery fond projects in collaboration with the automotive industry. Some key figures from the environment, with comparison along the four years of the programme s existence: StandUp for Energy Year Male Female PHD students PhD degrees recieved PhD =< 7 years 2010 142 52 65 8 41 179 2011 221 72 107 13 53 343 2012 274 96 154 34 74 459 2013 324 116 181 25 88 656 Peer revieviewed publications 45 (175)
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5. Strategiskt forskningsområde: Epidemiologi Huvudansvarig myndighet: Samrådande myndighet: Vetenskapsrådet FAS År 2010 2011 2012 2013 2014 Total budget 15 15 25 25 25 Avsättning till infrastruktur 3 3 5 5 5 Budget efter avsättning 12 12 20 20 20 5.1 Epidemiology: from mechanism to prevention, from surveillance to safety Huvudsökande: Karolinska Institutet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 10 127 300 Personell 6 128 181 Co funding from main applicant higher education institution 24 160 607 Running costs 2 100 425 Co-funding from-co-applicant higher education institution 0 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 4 372 135 Other costs 1 851 960 Other external funding 105 164 490 Totalt: 10 080 566 Totalt: 143 824 532 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution... N.B an exhaustive list is not required. Other external funding includes funding from public agencies (VR ca17%, FAS ca 24%, FORMAS ca 3%), funding from private foundations (Rausing 8%), public research foundations, egcancerfonden and SSF (8%), funding from the EU (ca 6%), NIH (ca 4%) and industry 8ca 9%). Co-funding from the main applicant Higher education institution includes support to the Swedish Twin Registry, part (20%) of support to KI Biobank, and other support to the PIs. Support from Stockholm County Council (other collaborators) includes support for the Center for Pharmacoepidemiology. 47 (175)
Please state the main priorities within the environment in 2013. (Question Q1) The overarching priority of the Strategic Research Environment has been to further develop a research environment for fostering young researchers within all fields of epidemiology represented by the three themes of the application, which are: Human interaction with microorganisms; Molecular genetic and clinical epidemiology: steps toward translational epidemiology; and Lifespan approach to health and disease. The priorities for 2013 can be summarized as Building Infrastructure and Utilizing Infrastructure for Research. Building Infrastructure: - Clinical data: The priority is to optimise data collection, particularly using systems integrated in clinical practice that will feed data into electronic medical filing systems, Quality of Care registers, as well as into research databases. - Biobanks: Establish nationwide biobanks of individuals before and after they develop disease and link with the Swedish Quality Registers for specific diseases, for the study of new prognostic markers. - Research cohorts and linkages: Establish and maintain large nation-wide register-based cohorts of incident (newly developed) cases of diseases together with healthy controls. Link ongoing studies with the national Prescription Registry to monitor drug use among the elderly. - Develop a cohort of reproductive outcomes and assisted reproductive techniques. - Establish neuroimaging database for studies of older adults -Create an identifiable, updated nationwide register of blood donations and transfusions. (Scandinavian donations and transfusions, SCANDAT). -Build further the LifeGene prospective cohort including pregnant women and their newborns. Utilizing infrastructure for research: -Combining genetics-, serological-, and clinical data to assess the importance of genes and risk factors for specific phenotypes within complex diseases such as Rheumatoid Arthritis - Though collaboration with worldwide networks, find novel genetic susceptibility markers to understand the mechanisms of several cancers including lymphoma subtypes, cardiovascular-, respiratory-, and inflammatory diseases. - Use these infrastructures to understand early risk factors for psychiatric ourcomes such as ADHD and the consequences of ADHD medication on later outcomes. - Clarify why the occurrence of systemic lupus erythematosus (SLE) varies. - Relate lifestyle to genetic backgrounds and detect their combined effect on longevity -Monitor time trends of the occurrence of dementia and disability among elderly people -Provide data and samples from LifeGene to researchers" 48 (175)
Please describe the major activities within the environment in 2013. (Question Q2) SFO Epi is responsible for several major cohort studies that provide the backbone of much of the research in the environment. Thus, the infrastructure activities include continued longitudinal data collection in the cohorts lead by SFO Epi investigators. SFO Epi also works in close collaboration with clinical quality care registers and is involved in the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) network, with the aim to promote, improve and expand use of registers in research. The environment has a very long list of research activities. As we prioritize the research of the junior faculty, examples of their research activities include: *Participation in national and international (e.g., EU-IMI) consortia on etiological studies of disease and assessments of risk factors, prognosis, response to therapies, drug safety, co-morbidity, outcome and costs in chronic diseases such as rheumatoid arthritis. *Studies of the association between dietary factors and risk of stroke in population-based cohort studies *Analysis of perinatal factors (fetal growth and early life predictors) on the risk of systemic lupus erythromatosis (SLE). *Studies on early risk factors for and genetic contribution to ADHD as well as the consequences of ADHD medication using national Swedish registers *Participation in large international consortia to identify novel genetic susceptibility genes, gene-environment interaction, and novel proteomic and metabolic biomarkers for cancers, coronary heart disease and dementia *Assess possible long- and short-term health effects of repeated blood donation including possible transfusion transmission of neurodegenerative disorders *Develop methods for the continuous surveillance of the blood supply to detect emergence of new transfusion-transmitted infections *Studies of work loss among working age cancer survivors in relation to cancer characteristics and treatment compared with the general population *Genetic and epigenetic analyses in ART vs non-art couples and in ART vs non-art offspring * Clinical studies on genetic and environmental risk factors in twins discordant for asthma and risk of adverse outcomes in pregnant women with asthma Activities focused on dissemination of results and outreach to the public include: * Research methodological course in Competing risks with invited national and international speakers and 40 attendees from all over Sweden and abroad * Dissemination of epidemiological methods: publication of an article series Tools in Clinical Research in the Swedish Medical Association journal (Läkartidningen), including 14 separate publications, with a SFO member as guest editor and other members contributing * Co-authorship in booklets produced SIMSAM. 49 (175)
Please describe the major results within the environment in 2013. (Question Q3) "Within the theme Human interaction with micro-organisms, we demonstrated that vaccination against the H1N1 virus increases the risk of narcolepsy but does not increase the risk for other immunological or neurological diseases. Within the theme Molecular, genetic and clinical epidemiology: steps towards translational epidemiology, we have several important results in Inflammatory diseases such as Rheumatoid Arthritis (RA) and multiple sclerosis (MS), Psychiatric outcomes such as ADHD, Cancer and Cardiovascular disease. Inflammatory diseases: In a series of studies, we have investigated the safety of biological therapies against chronic inflammatory diseases, risk factors for cardiovascular co-morbidities in RA, and trajectories of cost and productivity losses in different patient segments. In a large multi-generation study, we have shown how the strength of the familial aggregation of RA varies according to age, gender, and importantly subtype of the RA disease, and how established environmental and genetic risk factors barely explain any of the familial association of the disease. Furthermore, epigenome-wide association data identified differential DNA methylation in two clusters within the major histocompatibility complex region that potentially mediate genetic risk for RA. Through international collaboration we identified 48 new susceptibility variants for MS. Thus, there are now 110 established MS risk variants at 103 discrete loci outside of the major histocompatibility complex. Psychiatric outcomes: We have demonstrated the substantial role of genetic factors in the etiology of ADHD across the life span, clarified the role of genetic factors in comorbidity, and elucidated genetic underpinnings of different ADHD developmental trajectories. Even though maternal smoking during pregnancy and maternal obesity in early pregnancy are associated with ADHD in offspring, they are not causally related; rather these associations were explained by unmeasured familial factors. Preterm birth and advancing paternal age are strongly associated with offspring risk for ADHD. We have also developed a novel approach to study benefits and risks of ADHD medication using large-scale population-data, and have shown that ADHD medication reduces the risk for criminality, substance abuse and traffic accidents. We found that the previously reported association between maternal anxiety or cesarean section and respiratory disease is subject to familial confounding. These findings will have future impact on clinical practice. Cancer: The cancer forms we have studied are chronic lymphocytic leukemia (CLL), follicular lymphoma, Hodgkin lymphoma, prostate, and testicular cancer. Our findings have been instrumental in identifying susceptibility genes for these cancer forms, and identifying molecular markers of prognosis and survival. These findings give clues to mechanisms and an understanding of how environmental exposures lead to further risk and prognosis. Furthermore, we have shown how the increasing use of screening has completely shifted the pattern of mortality in that men recently diagnosed with prostate cancer are less likely to die from prostate cancer than from other causes Cardiovascular disease: Through international collaborations clinically important findings were noted as the identification of several novel genetic loci for cardiovascular diseases and various intermediate traits, findings of potential importance for new principles for development of drugs. Important results within the theme Lifespan approaches to health and disease include: We have found that high consumption of fruits and vegetables, fish, low-fat dairy products, chocolate, coffee, 50 (175)
and tea was associated with a reduced risk of stroke. In contrast, high consumption of red meat, especially processed meat, was associated with an increased risk of stroke. Many of these findings received considerable media interest. The risk of SLE increased with increasing parity, and as expected, being firstborn was associated with significantly lower odds of SLE in the future. We have documented adverse health effects of long-term exposure to ambient air pollution, particularly traffic-related respirable particles. This relates to cardiovascular effects, lung cancer and total mortality in adults as well as to lung function effects and respiratory infections in children. Furthermore, exposure during pregnancy resulted in an increased risk of low birth weight. We also showed that early life exposure to trafficrelated air pollution seems to have long-term respiratory consequences in susceptible groups, such as children with asthma or atopy. These results will have major consequences for city planning and responsible authorities such as the Swedish EPA and Stockholm Stad. We found that the prevalence of dementia had been stable from 1987-1989 to 2001-2004 in central Stockholm, while the survival of patients with dementia was increased. This study has significant implications for forecasting the economic and societal burden of dementia. We found that some factors that may modify the risk of dementia due to a protein (APOE ɛ4), that is, high education, active leisure activities, or maintaining vascular health could reduce the risk of dementia related to the protein APOE ɛ4." 51 (175)
5.2 Epidemiology for Health (EpiHealth): for Innovation and Excellence in Open-Access, Basic- Translational and Applied Epidemiological Research Huvudsökande: Lunds universitet 60% Medsökande: Uppsala universitet 40% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 10 057 000 Personell 7 178 009 20 300 591 Running costs 4 064 757 Co-funding from-co-applicant higher education institution 5 261 000 High cost Equipment 37 513 Funding from collaborating research institutes - Infrastructure running costs 771 552 Funding from other collaborators - Other costs 1 765 934 Other external funding 67 890 316 Totalt: 13 817 765 Totalt: 103 508 907 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. The contribution from external funding has been the following during 2013: VR: 30.00% FAS: 15% EU: 15% SSF: 10% Region Skåne (county council): 5% Please state the main priorities within the environment in 2013. (Question Q1) "Based on our initial application (2009) the three main priorities set in 2013 were the following for the strategic research area Epidemiology for Health (SRA EpiHealth): 1. To further strengthen an infrastructure for EpiHealth linking Lund University (LU) and Uppsala University (UU). 2. To promote excellence in epidemiological research, on a regional, national and international scale, including the set-up and start of an administrative hub ("nod") for BBMRI.se at LU, a national biobank platform. 3. To expand our screening project in persons aged 45-75 years (the EpiHealth Cohort) for evaluation of risk factors and mechanisms behind common chronic disease conditions (i.e. cancer, cardiovascular disease, diabetes, dementia, musculo-skeletal disorders, etc.) RESEARCH AND RESEARCH ENVIRONMENT The main priority is to expand the EpiHealth Cohort, based on screening activities in Uppsala (started in 2011) and Lund/Malmö (started in 2012), now reaching a number of more than 12,400 screened subjects and open 52 (175)
for external and internal research proposals. Furthermore, we have aimed to strengthen the research infrastructure by new recruitments of co-workers and academic specialists. ORGANIZATION We aim to to further develop an effective leadership structure and administration, while also promoting gender balance in all activities. EDUCATION AND DISSEMINATION Priority has been given to a number of local, national and international scientific symposia, meetings and conferences, and several of these have been successfully accomplished with a good attendance and high quality scientific presentations. RESEARCH COLLABORATIONS We have set a priority to promote international contacts and projects, and also developed contacts with industry, organizations and authorities for research and innovation, most importantly Astrazeneca AB and the National Board of Health and Wellfare. In addition we have worked with Danish colleagues within a EU Interreg IVA programme, ending in 2013." Please describe the major activities within the environment in 2013. (Question Q2) "RESEARCH AND RESEARCH ENVIRONMENT During 2013 we have continued the screening project for the EpiHealth population-based cohort in Uppsala (six nurses involved) and in Malmö (four nurses). Blood samples have been sent for biobanking in collaboration with the biobank belonging at the Karolinska Institute, Stockholm. This is done in collaboration with BBMRI.se, which has meant substantial cost reductions. During 2013 the collected data and biobank samples became available for use in research projects based on applications from researchers both within and outside the EpiHealth network (open access). We also continued to collect information for a regional register or library of all cohorts useful for epidemiological research within the LU area,but also open for applications on a national basis. ORGANIZATION We have further developed our internal structure for leadership (with a Steering Committee and an Executive Committee) and information (web site: www.med.lu.se/epihealth) with focus on leadership, administrative training and development. To reach equal gender balance at all levels of the organization, we have therefore promoted an active participation of female researchers in the leadership and representation of EpiHealth as well as in organizing symposia, seminars and meetings. The Vice Coordinator (Marju Orho-Melander) has played an important role for representing EpiHealth at local and national meetings. Karin Källén (LU) and Liisa Byberg (UU) have further organised the EpiHealth network and recruited new members. EDUCATION AND DISSEMINATION We have been organizing local, national and international meetings, for example a symposium on cardiovascular epidemiology in Malmö (March 21) and a satellite symposium on biomarkers for the European Society of Hypertension (ESH) in Malmö (June 7-8). In addition, we have supported the European Association for the Study of Diabetes-Study Group of Genetics of Diabetes (SGGD) meeting in Malmö (Marju Orho- Meander) with 150 attendees and invited speakers representing the top diabetes researchers in Europe. In 2013 the annual EpiHealth network conference held in Uppsala (October 17-18) was named the first National conference on biobanks and population cohorts (Lars Lind). In addition, a third conference for research-group leaders and PhD-students at Lund University held at Örenäs castle outside Lund (November 7-8) was well attended. The annual Advanced course in epidemiological methods, this time on "Early life influences on health", was held in Malmö (January 14-15) 2013. 53 (175)
RESEARCH COLLABORATIONS On the local level, contacts with other strategic research areas have been further developed, especially with essence-lu for a joint project on improving the technical surveillance of the fetus during delivery (Karin Källén), as well as with EXODIAB for projects in diabetes epidemiology (Marju Orho-Melander, Paul Franks). A promising project that started in 2012 has further expanded with the aim to investigate protective factors against complications in long-standing type 1 diabetes, the PROLONG study (Valeriya Lyssenko), now including 10 hospital regions and also the Steno Diabetes Center in Copenhagen, Denmark, where activities started in 2013. Further, Olle Melander and Marju Orho-Melander have initiated and performed studies connecting cardiometabolic researchers and cancer researchers to investigate the epidemiological connection between these diseases (genetic markers, environmental factors and blood biomarkers). Finally, Orho-Melander has initiated collaboration with Inger Björck s group at LTH and Antidiabetic Food Center, at LU. On the national level, we have research collaborations, most importantly with LifeGene - a project for screening and biobanking of samples from persons aged 0-45 years that was been allowed to re-start in December 2013, and with BBMRI.se - a national infrastructure for development of modern biobanking with European contacts. In April 2013 Peter M Nilsson was appointed to be the leader of the LU hub of BBMRI.se in collaboration with the biobank structure of the county council (Region Skåne) and the Lund Technical University (Carl Borrebaeck). Similar activities are ongoing in the Uppsala Biobank structure (Anna Beskow). Most importantly, a number of joint projects linked to EpiHealth have been developed with researchers at LU and UU in collaboration. These include for example: a project on Meta-health data analyses based on data from several epidemiological cohorts (Johan Sundström, UU, and Gunnar Engström, LU); a project on bone metabolism and fracture risk (Karl Michaelsson, UU, and Martin Englund, LU); a project on genetic mapping of cardiovascular risk (Erik Ingelsson, UU, and Olle Melander, LU); and projects on interactions between genes and diet in liver fat accumulation (Marju Orho-Melander, LU, and Ulf Riserius, UU) and type 2 diabetes (Marju Orho-Melander, LU, and Rikard Landberg, UU). On the international level, we have developed active collaborations, i.e. based on a joint EU Interreg IV project linking southern Sweden (Scania) and eastern Denmark (Själland) in a project dedicated to cardiovascular epidemiology in populations and cohorts of patients. In addition we have strengthened research dedicated to social and public health epidemiology (Stanford University) and genetic epidemiology (Broad Institute, Baltimore)." Please describe the major results within the environment in 2013. (Question Q3) "RESEARCH AND RESEARCH ENVIRONMENT One important result during 2013, has been the continuation and widening of the EpiHealth screening cohort project in Uppsala and in Malmö, which has so far recruited more than 12,400 persons. The screened subjects have filled in a web questionnaire, participated in clinical examinations, and donated blood samples for further biobanking and DNA extraction in collaboration with BBMRI.se and the KI biobank. We have also further updated the biobank and data collection from the Womens Health in the Lund Area (WHILA) cohort including 6900 postmenopausal women from1995-1997. Under leadership of Olle Melander (LU), around 14,000 individuals from the Malmö Diet and Cancer study have now been genotyped "genome wide" for around 1,000,000 genetic markers (GWAS and exome chip) and in 2013 the first genetic analyses have been carried out (Olle Melander). This is a collaborative approach of several investigators, for example with partial financing from Jonas Manjer (LU) for breast cancer cases, Hans Lilja (Memorial Sloan-Kettering Cancer Center, New York) for prostate cancer cases and Marju Orho-Melander (LU) for incident type 2 diabetes cases. A number of important scientific papers have been published during 2013 in high impact journals. ORGANIZATION Research administrator Camilla Key has been employed full time during 2013. She is also web-master for our web site (www.med.lu.se/epihealth) collecting all new informations and reports from activities, and constantly updated. The vice coordinator Marju Orho-Melander has been actively representing EpiHealth both at the LU level and at regular meetings with the National Biobank Board ( Nationella Biobanksrådet ). Young female researchers have been given opportunities to attend research courses or to spend time devoted to their 54 (175)
research as financed by EpiHealth. Currently an almost equal number of men and women belong to the EpiHealth network. Regular meetings have been held within the leadership structure, based on regular telephone meetings with the EpiHealth Steering Committee, as well as with the Executive Committee. We had one meeting in person with the steering committee on October 17th in Uppsala. Protocols are kept. EDUCATION AND DISSEMINATION Two successful larger symposia, as well as smaller conferences and meetings during 2013 have been well attended by numerous participants. The major international symposium organized during 2013 by EpiHealth was the satellite symposium on "New frontiers of biomarkers in cardiovascular disease" held in Malmö 7-8 June, with a broad attendance of around 80 delegates from ten countries. RESEARCH COLLABORATIONS For our annual conference in Uppsala (16-17 October), EpiHealth invited delegates from all of Sweden to attend with the intention to widen the network also to individuals and universities not primarily involved in EpiHealth. The theme was biobanks and large cohorts in Sweden, with presentations from all universities, as well as from LifeGene, BBMRI.se and from related international projects such as LifeLines in the Netherlands and the UK Biobank. We have also continued our contact with the research network behind the Northern Sweden MONICA study at the Umeå university (Stefan Söderberg, Mats Eliasson) for joint projects and publications and in planning of the next MONICA survey in 2014. The EU Interreg IV project with Danish researchers (2011-2013) has resulted in extensive contacts and a final summing-up seminar organised in Malmö (December 18), attended by 30 delegates as well as representatives from "Öresundssekretariatet" for EU Interreg IV in Copenhagen. We have organised regular Skype-conferences and meetings in Malmö and Copenhagen. A separate web site has been created (www.skarf.eu). We have continued our collaboration with Karolinska Institute (KI), Stockholm, for biobank routines, in collaboration with the BBMRI.se hub in southern Sweden where EpiHealth will play an important role as the representative of LU. A new automated robot system for lab sample handling has been ongoing at the Clinical Research Unit at the Scania University Hospital in Malmö based on this collaboration with KI (Kerstin Andersson). The collaboration with the Strategic Research Environment essence-lu for a joint project on improving technical surveillance during delivery was supported by a grant of 1.6 million SEK from essence during three years (Karin Källén representing EpiHealth). In addition we have started a collaboration with MultiPark for development of epidemiology and supporting a national research school dedicated to ageing. We also collaborate with other strategic research areas at LU in setting up new resources for bioinformatics, as supported by the LU administration. We have started a number of joint research projects between researchers at LU and UU aiming for joint publications in 2014." 55 (175)
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6. Strategiskt forskningsområde: E-vetenskap Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: Vinnova År 2010 2011 2012 2013 2014 Total budget 25 40 70 70 70 Avsättning till infrastruktur 5 8 14 14 14 Budget efter avsättning 20 32 56 56 56 6.1. Swedish e-science Research Centre Huvudsökande: Kungliga Tekniska Högskolan 38% Medsökande: Linköpings universitet 27%, Stockholms universitet 27%, Karolinska Institutet 8% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 30 000 000 Personell 21 723 000 15 900 000 Running costs 2 859 000 Co-funding from-co-applicant higher education institution 18 900 000 High cost Equipment 28 000 Funding from collaborating research institutes 0 Infrastructure running costs 1 170 000 Funding from other collaborators 0 Other costs 8 229 000 Other external funding 190 174 000 Totalt: 34 009 000 Totalt: 254 974 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. Source Sum of kkr Funding from public agencies (PA) 123 179 Public research foundations (RF) 21 496 EU-framework programmes (EU) 36 205 Other international funding (IF) 720 Private non-profit organisations (NP) 8573 Private companies (PC) 0 Totalt: 190 174 57 (175)
Please state the main priorities within the environment in 2013. (Question Q1) "The main priority within the Swedish e-science Research Centre (SeRC) during 2013 has been to establish the framework for a permanent e-science collaboration involving all four partners after 2014, while focusing on the areas where SeRC groups are internationally leading. We have formalized the structured collaborations between core and applied e-science areas, and the SeRC steering group has developed a strategy for a national human e-cloud for e-science that builds an infrastructure based on academic researchers, application experts, and technical experts. We have also put a large effort on community meetings, e-science education and our faculty leadership program where the younger scientists recruited for SeRC have now formulated their own future common research aims. During 2013 the SeRC steering group has had several multi-day meetings, and discussions with our Advisory board, to define the strategy for SeRC after 2014. An important part of this is the formation of SeRC as a formal joint center between all four partner universities (KTH, LiU, SU and KI). This was realized and in operation since december 2013, with KTH as host university. Another part of the strategy is based on an internal evaluation. SeRC consists of ten communities, six within applied areas like Molecular Simulations or Climate Modeling and four focusing on core e-science facilities like Visualization or Data Management. During 2013 we performed an internal evaluation of all SeRC communities to identify strengths and weaknesses and to learn from each other. This resulted in a set of recommendations for each community, and has also influenced the distribution of funding. Interdisciplinary collaborations have been a main priority of 2013. SeRC initiated the flagship program e- Science for Cancer Prevention and Control (ecpc) in 2011. Based on input from the SeRC advisory board in 2013, two additional flagship programs have been started, SESSI the SeRC Exascale Simulation Software Initiative, which will enable a few leading Swedish and foreign simulation research codes to scale to nextgeneration supercomputers, and Collaborative Visual Exploration and Presentation, where visualization tools for large data sets and compute intensive simulations will be developed. All three flagship programs include researchers from different disciplines and SeRC communities, as well as dedicated application experts working at the supercomputing centers. During 2013 SeRC has also prioritized industrial and societal interactions more, especially through our industry coordinator, in close contact with industry and the SeRC communities. Finally, a major focus has been on e-science education resulting in the formation of a new graduate school in e- Science, the Swedish e-science Education graduate school (SeSE). SeSE provides basic training in fields where the use of e-science is emerging and where education can have an immense impact on the research, but also advanced training for students in fields that are already computer-intensive." Please describe the major activities within the environment in 2013. (Question Q2) The major management activities during 2013 have been focused on achieving a permanent structure for SeRC. We have organized multiple meetings for the SeRC faculty recruited in the project, at which external experts have helped design an organization where the entire faculty takes part in formulating goals and defining how their work interacts with SeRC. Based on the feedback from the meetings this has been much appreciated and helped the faculty at the four partner Universities to feel like a single team. The steering group has also had two-day meetings to formulate their strategy, both for the SeRC management and also concerning how the human expert e-science infrastructure should be developed nationally in Sweden. An important part of this strategy work has been the discussions with and recommendations from the SeRC Advisory group. During spring of 2013 an internal evaluation was performed. Every community organized a meeting for external evaluators from the SeRC management group. All projects SeRC-financed and others - were analyzed as well as other factors such as interdisciplinary collaborations, application experts working with each community, and 58 (175)
outreach. The evaluations resulted both in oral and written reports with a set of recommendations for each community, which were included in the SeRC strategy. The fourth annual meeting of SeRC took place two days in spring 2013. The number of participants was limited to 100, since the meeting was located at the dome of Visualization Centre C in Norrköping. In addition to a graphical demonstration of the most complex visualization of the universe developed to date (developed by SeRC researchers), several prominent speakers participated and there was a panel discussion with the SeRC Advisory board. In addition to community and annual meetings, there were two special major SeRC-hosted seminars with large attendance in 2013; one about the Human Brain Project with Sean Hill, co-director of Neuroinformatics in the Human Brain Project; the other one with the 2013 Nobel laureates in Chemistry (Martin Karplus, Michael Levitt and Arieh Warshel), discussing creativity and creative environments in science. Several smaller workshops and seminars have also taken place, and SeRC has been highly visible in national television and radio with multiple interviews and hour-long science programs related to the 2013 Nobel Prize in chemistry as well as the release of the IPCC-report. In preparation for the EU Horizon 2020 project, we have built on the success of a number of SeRC groups in attracting e-science infrastructure funding in EU FP7, and SeRC is now leading at least one European network to propose a distributed computational competence center in Horizon 2020. There have also been educational activities. The Swedish e-science Education graduate school (SeSE), which was started by SeRC in collaboration with essence (another SRA), has given 7 different e-science courses during the autumn 2013. Prior to this, the project also financed and implemented a number of SeRC-specific PhD courses in 2013, primarily aimed at SeRC PhD students. Please describe the major results within the environment in 2013. (Question Q3) " During the year, SeRC researchers published over 400 scientific works in refereed journals, 40 refereed conference contributions, and another 70 publications from other categories (books, etc.). This is reflective of large amounts of additional national/international funding secured directly by researchers, but a significant number of publications are new collaborations between SeRC groups. In particular the new junior investigators recruited in the initiative have been extremely successful and awarded prestigious career grants from The European Research Council, The Knut & Alice Wallenberg Foundation and Vetenskapsrådet. Of the many strong results, this space is only enough to list a few: Within life sciences, researchers in the SeRC Bioinformatics community at SU were responsible for method development and analysis for parts of the Norwegian spruce genome, which is the largest genome sequenced to date (performed in collaboration with Science for Life Laboratory). This work was published in Nature earlier this year, and is a strong example of how the two strategic research areas complement each other very well. Similarly, long-standing collaborations between SeRC researchers in Molecular Simulation at SU and KTH and the Danish leading research environment on membrane protein pumps in Aarhus made it possible to combine molecular dynamics simulations with low-resolution experimental data to derive the first-ever structures with ions bound of the Sodium-Potassium pumps that are the engines of our nervous system this work has been published in Science. The electronic structure community created the first multiscale model simulations of how spectroscopic probes will behave in cellular membranes (in collaboration with Molecular simulation); this work has appeared in the highest-ranking international journal in the field of chemistry (JACS). SeRC researchers in Neuroinformatics at KTH, SU and KI (who are also the main Swedish site in the EU flagship Human Brain Project) have developed and published models at different levels of resolution of the basal 59 (175)
ganglia system in the brain. The SeRC T-MedFusion translational informatics platform and research database has been connected to the decision support system in healthcare via the Stockholm county healthcare system, which makes it possible to connect clinical and molecular data. The Complex Disease project on cancer prevention and control has completed multiple simulation/prediction models for screening prostate and cervical cancers by using machine learning, which will be used in the upcoming STHLM3 study of prostate cancer screening on 50,000 men to make biopsy decisions based on results from biomarkers in blood samples and genetic tests. Several SeRC research groups doing large grid-based simulations have also had large international impact. The Fluid dynamics community has been the single most successful Swedish team with a total of three projects accepted for the EU PRACE high-performance computing infrastructure, and the community on Climate modeling was one of the partners in the international ensemble simulation of the CMIP5 database. 60 (175)
6.2 essence An escience Collaboration Huvudsökande: Uppsala universitet 45% Medsökande: Lunds universitet 35%, Umeå universitet 20% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 26 000 000 Personell 17 997 900 62 676 606 Running costs 2 527 588 Co-funding from-co-applicant higher education institution 48 407 489 High cost Equipment 60 878 Funding from collaborating research institutes 151 877 Infrastructure running costs 0 Funding from other collaborators 0 Other costs 5 643 793 Other external funding 127 154 940 Totalt: 26 230 159 Totalt: 264 390 912 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. Rough estimate of the funding sources under "Other external funding" and their relative contribution: Public agencies: 54% Public research foundations: 8% EU framework programmes: 23% Private foundations and non-profit organizations: 10% Other funding: 5% Please state the main priorities within the environment in 2013. (Question Q1) " Research The essence mission is advancing science through leading computation, information, and communication technologies. The nature of e-science as a common denominator in a wide range of subjects and applications, requires a well-functioning platform that can enable contact and collaboration. New collaborations and novel applications have been added in the four focus areas, Materials Science, Life Science, Human Function and Environment, and Generic e-science Methods and Tools and essence now includes more than 30 projects. In 2013, essence performed an internal review of its projects to ensure that the vision and plan stated in the original application was on track. As a result, some particularly promising projects were assigned more funding to guarantee their successful completion by 2014.Education Although the essence funding is to be devoted to research, the essence management takes responsibility for 61 (175)
national e-science education in order to raise the level of knowledge about e-science. One of the priorities in 2013 has been to, in a joint effort with SeRC, establish the Swedish e-science Education graduate school (SeSE) offering courses on e-science to PhD students.outreach Many essence scientists have collaborations with the industry and the business sector in their specific research areas. In an attempt to create new contacts with non-traditional industrial sectors, essence hosted a meeting between e-science academic researchers and various companies. The format of this meeting, called AIMday e-tools & Methods, is that each registered company presents at least one specific industrial problem they wish to discuss. Scientists receive the questions in advance and select those which they consider to have expertise in. Discussion groups are then formed around each question. Members of a wide range of industrial sectors, active in the areas of energy, insurance, construction and pharmaceutics, submitted questions. This shows the growing importance of e-science research and education, not only in academia, but also for the business and public sectors.planning for the future The three universities have made long-term commitments for the continuation of a strong e-science community. It includes recruitments to faculty positions, responsibility for national e-science education, support for the formation of interdisciplinary e-science groups, and close contacts with e-infrastructures such as the SNIC centres. The growing visibility and impact of essence is resulting in a number of researchers taking leading roles in e-science research policy and funding, and in various national and international committees, as for example in the Swedish Research Council and in scientific programme boards of international e-science conferences." Please describe the major activities within the environment in 2013. (Question Q2) "The main activity in essence is the research performed by the groups in the environment. Some of the research results are described in Q3. Other important activities that took place in 2013 were:essence Academy The second annual essence Academy was held in October 2013, allowing members from the essence environment to meet and discuss e-science. 80 researchers from Lund, Uppsala and Umeå participated and the progress of the essence funded projects was presented in plenary talks and posters. A common reaction among the participants was that they enjoyed the opportunity to see the width and breadth of the area and interact with colleagues of different backgrounds.thematic workshops broadening the community With the ambition to broaden the essence community, essence has contributed to the organization of a number of thematic workshops and conferences at all three partner Universities, including Annual Meeting on Multiscale Materials Modelling; Workshop on Macromolecular Structure and Dynamics; The 1st Cloud Control Workshop; Advances in Numerical Analysis and Computational Sciences; Data Management and Workflow; Informatics and e-questions; and the PRACE Spring School 2013 on New and Emerging Technologies - Programming for Accelerators.Graduate school SeSE. Jointly with the Swedish e-science Research Centre (SeRC), essence established in 2013 a national graduate school for e-science technologies built upon experiences from the graduate schools NGSSC (founded 1996) and KCSE (founded 2007). The Swedish e-science Education graduate school (SeSE) provides basic education in fields where the use of e-science is emerging and where education can have an immense impact on the research as well as advanced education for students in fields that are already computer-intensive. AIMday e- Tools & Methods Approximately 40 participants (researchers and company representatives) attended a meeting between academy and industry hosted by essence. Companies representing branches of energy, insurance, 62 (175)
construction and pharmaceutics came to discuss open questions with the academic expertise in e-science. The preliminary results of the meeting are very positive.involvement in the Nobel Prizes 2013 in Physics and Chemistry In 2013, the Nobel Prizes in both physics and chemistry were awarded to advances in research that rely on e-science which is also represented in essence. In fact, the 2013 Nobel Laureates in chemistry visited and gave lectures at all three essence universities, with which they have close scientific contacts." Please describe the major results within the environment in 2013. (Question Q3) " Here, we present a small selection of important results from the research groups:materials Science The chemical industry utilizes catalysis in the manufacture of more than 90% of its products. Catalysis keeps production costs down, saves energy, yields purer compounds and helps eliminate pollutants. Reactive metal oxide surfaces and nanoparticles play a key role in catalysis. With the help of multi-scale simulations in the area of Materials chemistry, new catalytic reactions have been discovered that are specific for small nanoparticles. This can change the strategy for catalyst design in the future. Clay is not only common in the ground, but is also found in many applications, such as in cosmetics, paint, paper, and as a lubricant when drilling for oil. It is also planned to be used as a buffer and barrier around the containers of nuclear waste in long-term storage. Clay consists of very wide and thin charged sheets, called platelets. Simulations can be used to understand the properties of platelets on a microscopic level. However, the complexity of the system is such that simulations become prohibitive beyond relatively small platelets in a standard model. A new scheme has been devised to simplify the model further without losing information about interactions. This will allow simulations with many, larger platelets. The use of theoretical computations has become standard in the design and development of new compounds with pharmacological activity. Computational methods have been developed for predictive drug discovery based on both molecular simulations and statistical modelling. Enzymes catalyse most of the chemical reactions in the living cells and play a central role in virtually all lifesupporting processes such as digestion, respiration and metabolism. Studying the evolutionary history of enzymes can help us understand important mechanisms, such as how toxic substances can be eliminated. Methods have been developed for simulating enzyme evolution at the molecular level and for studying how catalysis of new chemical reactions can emerge. The computational approaches are based on the 2013 Nobel prize in chemistry. Two essence group leaders have a close collaboration with one of the Nobel Laureates (with whom they have published over 45 scientific papers). Advanced production of wood and wood-derived products for new materials and biofuels requires understanding of the molecular mechanisms behind growth and development in trees. e-science tools are being developed for data integration that will characterize and predict functional biology and phenotypic traits in Norwegian spruce, Poplar trees and Arabidopsis plants. Life Sciences The use of theoretical computations has become standard in the design and development of new compounds with pharmacological activity. Computational methods have been developed for predictive drug discovery based on both molecular simulations and statistical modelling. Enzymes catalyse most of the chemical reactions in the living cells and play a central role in virtually all lifesupporting processes such as digestion, respiration and metabolism. Studying the evolutionary history of enzymes can help us understand important mechanisms, such as how toxic substances can be eliminated. Methods have been developed for simulating enzyme evolution at the molecular level and for studying how catalysis of new chemical reactions can emerge. The computational approaches are based on the 2013 Nobel prize in chemistry. Two essence group leaders have a close collaboration with one of the Nobel Laureates (with whom they have published over 45 scientific papers). Advanced production of wood and wood-derived products for new materials and biofuels requires understanding of the molecular mechanisms behind growth and development in trees. e-science tools are being developed for data integration that will characterize and predict functional biology and phenotypic traits in Norwegian spruce, Poplar trees and Arabidopsis plants. Human Function and Environment 63 (175)
Robust image analysis methods for identification of individual cells in large-scale biomedical experiments have been developed. These methods will enable the study of the effects of a wide range of chemical and genetic perturbations on primary cell cultures from cancer patients with an aim to characterize therapeutically relevant regulatory differences between tumors and to optimize patient treatment. In demographic studies, historical records of births, deaths, employment, migration, etc., are collected into longitudinal databases to be able to follow generations and see how circumstances affect the health of the descendants. A standard has been developed for storing geographic data compatible with an international standard for organizing historic demographic data. Demographic data have been integrated with historical maps and modern geographic information to create a unique database for the study of effects of geographical conditions, such as environmental risk factors and questions related to epidemiology. Measurements of human eye movements (eye-tracking) can be applied to practical problems related to the way humans look at the world. Robust and accurate methods have been developed for measuring what happens when a text is read and when the eye follows moving objects, such as animated ads or cyclists on the road. The project has identified different types of eye movements that show how the eye registers the visual information. Common in e-science applications are High-throughput computing workloads, where the usefulness of the results relies completely on speed. The workloads typically consist of vast numbers of independent computations, and/or handling of high volumes of data generated continuously by sensors, medical equipment, computer simulations or experiments. New algorithms that exploit several levels of parallelism have drastically improved computational performance and high-volume data-stream management. Allowing programmers to efficiently exploit parallelism in both computations and data handling, without precise knowledge of the parallel architecture of the computer at hand, is a major challenge. Novel contributions in this direction include parallel programming models and adaptive scheduling systems. The performance of a wide variety of products can be enhanced through the use of computational design. New robust methods and software for the design of ultrawideband directional antennas and various acoustic devices have been developed.generic e-science Methods and Tools Common in e-science applications are High-throughput computing workloads, where the usefulness of the results relies completely on speed. The workloads typically consist of vast numbers of independent computations, and/or handling of high volumes of data generated continuously by sensors, medical equipment, computer simulations or experiments. New algorithms that exploit several levels of parallelism have drastically improved computational performance and high-volume data-stream management. Allowing programmers to efficiently exploit parallelism in both computations and data handling, without precise knowledge of the parallel architecture of the computer at hand, is a major challenge. Novel contributions in this direction include parallel programming models and adaptive scheduling systems. The performance of a wide variety of products can be enhanced through the use of computational design. New robust methods and software for the design of ultrawideband directional antennas and various acoustic devices have been developed. Some key figures in essence for 2013:eSSENCE 2013 Personnel: Total/Female 346/60 PhD students 128 Personnel with Doctoral degree less than 7 years old 47 Peer-reviewed publications: Journals/Conference papers 242/108" 64 (175)
7. Strategiskt forskningsområde: Havsmiljöforskning Huvudansvarig myndighet: Formas Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 10 15 20 20 20 Avsättning till infrastruktur 1 1 2 2 2 Budget efter avsättning 9 14 18 18 18 7.1 Ecosystem Approach to the Baltic Sea Huvudsökande: Stockholms universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 9 755 000 Personell 10 274 000 Co funding from main applicant higher education institution 13 272 000 Running costs 660 000 Co-funding from-co-applicant higher education institution - High cost Equipment - Funding from collaborating research institutes - Infrastructure running costs - Funding from other collaborators - Other costs 270 000 Other external funding 10 500 000 Totalt: 11 204 000 Totalt: 33 527 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.. N.B an exhaustive list is not required. Several large, 3- or 4-year grants from the Swedish research council Formas to SU for Baltic Sea research that were received in mid-december 2009 have been included in this strategic environmental research area. The 4- year grants were formally for the period 2009-2012, but in practice they have run for 2010-2013, and their funding for 2012 (9.2 MSEK) has been included for 2013 in this summation, to avoid showing a misleadingly large decrease in external funding in 2013. In addition there was 0.725 MSEK in doctoral student support from the Swedish Nuclear Fuel and Waste Management Co (SKB), and 0.553 MSEK for the same purpose from the Nordic Centre NorMER. Several of the researchers involved in BEAM have later received considerable grants for research on Baltic Sea issues that have not been included in the research area, for two reasons. The reporting would involve much extra administrative work, and since most of the money has been received recently, the research has just started, and there will be rather few results to report within the timeframe of BEAM. 65 (175)
Please state the main priorities within the environment in 2013. (Question Q1) The main priorities have been: 1. To ensure high quality in carrying out the planned disciplinary and interdisciplinary research in support of Baltic Sea ecosystem management. 2. To stimulate research collaboration in this field, both within Stockholm University, and with crucial external contacts, such as the corresponding strategic marine environmental programme EcoChange, led by Umeå University, the Swedish Hydrological and Meteorological Institute and numerous other national and international collaborating institutes. 3. To support the start-up of Stockholm University s new Baltic Sea Centre. 4. To inform stakeholders, managers and the public in the Baltic Sea area and researchers world-wide about Baltic Sea research relevant to ecosystem management, including the BEAM programme. Particularly important was the establishment of cooperation with the new Swedish Agency for Marine and Water Management." Please describe the major activities within the environment in 2013. (Question Q2) "The main activities continued to be new and innovative basic and applied research, with intensified scientific cooperation and an increase in scientific publications and dissemination of results at conferences, meetings and workshops. BEAM has intensified internal communication and cooperation to stimulate inter-project and interdisciplinary research, with an emphasis on younger researchers. This has involved a number of courses, seminars and workshops. For example, two doctoral courses, Modeling as a tool to study the Baltic Sea ecosystem - Possibilities and challenges, in March, and Baltic Sea ecology and diversity fundamentals, on-going research and a hands-on experience, in September, stimulated internal as well as international cooperation. The midterm science plan adopted by the BEAM Steering Group in May was developed together with all scientists involved in the strategic programme, and stresses interdisciplinary cooperation and management relevance. The work stimulated by this plan was presented and discussed at the BEAM annual meeting in November. Through participation of BEAM researchers at several international conferences, workshops and symposia, and in international working groups, the objectives and research ideas of BEAM have been presented to a wide international audience. BEAM scientists have also been active in advising governmental agencies and organisation in Sweden and abroad on issues related to marine environmental quality and management." Please describe the major results within the environment in 2013. (Question Q3) "Climate: BEAM researchers have shown that regional climate models for the Baltic area poorly describe observed trends in precipitation and freshwater discharge to the Sea in Sweden. One reason is probably that they fail to account for changes over time in land-use and vegetation and resulting changes in evapotranspiration. Future regional climate models may have to incorporate the different responses of forests, mountains, and agricultural lands to better model freshwater discharge and hence nutrient loads to the Baltic Sea. Major inflows of saltwater to the Baltic Sea can be predicted from changes in sea level air pressure. Atmospheric conditions conducive to inflow have been less frequent in recent decades; hence deep-water oxygen deficiency has worsened, even though nutrient loads have decreased. For a selection of future scenarios, modelling predicts that situations favouring inflow are likely to become slightly more common in the future. By analysing long-term phytoplankton monitoring time-series, BEAM researchers found that the spring-bloom 66 (175)
now arrives earlier, and that diatoms are favoured by ice winters. Long time-series of satellite observations likewise indicate that summer blooms of cyanobacteria are gradually occurring earlier. The combined effects of the increase in cyanobacteria abundance, warming of the sea surface and decrease in ph on pelagic grazers in the Baltic was studied experimentally. The results suggest that cyanobacteria may partially alleviate the otherwise negative effects of predicted temperature increase and decreasing ph on the reproduction and recruitment of zooplankton and, thus modulate impact of climatic changes in pelagic food webs. Monitoring methods: BEAM results indicate that estimates of surface water quality (transparency, chlorophyll) from satellites are now comparable in quality to ship-based data in the Baltic proper, with much better resolution. They are now used operationally to classify ecological status in the coastal zone. Collaborative work with Umeå University (EcoChange) is under way to extend this capability to the Gulf of Bothnia and to estimates of coloured dissolved organic matter. Hazardous substances: BEAM has developed a novel tool for modelling transport and distribution of organic contaminants in the Baltic Sea. This is an important milestone in the development of a tool-kit to facilitate ecosystem-based managment of organic contaminants. It builds on the model used to calculate nutrient distribution and effects for the HELCOM Baltic Sea Action Plan, and will allow studies of interactions with other drivers affecting conditions in the Baltic Sea, such as climate change, eutrophication and fisheries. BEAM research confirmed that naturally produced hydroxylated and methoxylated polybrominated diphenylethers (OH/MeO-PBDEs) are widespread in Baltic biota. This is important as studies on Zebra fish showed that several OH-PBDEs are highly toxic. The neurotoxic amino acid BMAA, produced by some phytoplankton, was shown to inhibit nitrogen fixation in a cyanobacterium. Ecosystem and Eutrophication: The 15N-method of measuring nitrogen fixation was recently found to give systematic underestimations. BEAM therefore developed and tested an improved method that also showed that some of the nitrogen fixed by cyanobacteria is transferred up the food-web to zooplankton. This was confirmed by BEAM studies using the stable isotope ratio δ15n in phytoplankton, zooplankton and benthic invertebrates. Denitrification was demonstrated in colonies of the cyanobacterium Nodularia, but is quantitatively larger in the transition layer (chemocline) between oxygenated surface water and oxygen-free deep water and sediments in the Baltic proper. Here denitrification is an important process removing nitrogen, a main cause of eutrophication, while also oxidizing toxic hydrogen sulphide. BEAM also found that the surface sediment is a major site of denitrification, which can be stimulated by up to 30% by high abundance of microscopic meiofauna. The export of organic matter from the surface layer drives Baltic oxygen deficiency and is important in modelling eutrophication, but its magnitude has been much debated. Sediment trap data indicate low export rates, except during the spring bloom, while estimates of oxygen consumption and of food needed to sustain benthos suggest higher rates. A BEAM study based on several independent methods found four methods that give compatible estimates, indicating that 21-30% of the annual phytoplankton primary production is exported. Several BEAM studies of the connection between ecosystem management and fisheries have tried new multimodel approaches to finding management solutions robust to details in the modelling, and have indicated that management has the potential to make a large difference in the future state of the Baltic ecosystem. Laws and Management: BEAM research showed that HELCOM did not reorganize itself to suit its adoption of the ecosystem approach to management, but only made minor, gradual adjustments. This has created a mismatch between the ecosystem and the organization for its management, which may therefore not be able 67 (175)
to respond appropriately to future rapid ecosystem shifts. BEAM legal researchers made trans-disciplinary studies of the legal means of environmental control and governance in international, EU and national laws, as they apply to the Baltic Sea Area. Different legal mechanisms, functions and structures were examined to see whether they support or impede effective ecosystem-based management and resilience of the social-ecological systems, and how they should be considered in research on ecosystem management and resilience." 68 (175)
7.2 Ecosystem dynamics in the Baltic Sea in a changing climate perspective ECOCHANGE Huvudsökande: Umeå universitet 60% Medsökande: Högskolan i Kalmar 40% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 8 347 000 Personell 4 654 822 4 476 626 Running costs 1 463 520 Co-funding from-co-applicant higher education institution 1 750 000 High cost Equipment 0 Funding from collaborating research institutes 50 000 Infrastructure running costs 0 Funding from other collaborators 0 Other costs 1 822 825 Other external funding 8 143 000 Totalt: 7 941 167 Totalt: 22 766 626 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Other external funding 8 143 000 EU framework programmes 474 282 Public research foundations 4 325 718 South Baltic programme 519 000 Private research fundations 2 824 000 Please state the main priorities within the environment in 2013. (Question Q1) "ECOCHANGE main priorities during 2013 were to perform marine research, collaboration, net-working, education, publication and knowledge-transfer, according the plan outlined in the application. We prioritized to perform field studies and key experiments on effects of climate change on marine production and biodiversity and the distribution of persistent organic pollutants. Applied research on measures to increase coastal fish recruitment were performed and strategies for designing monitoring programs were developed. We put emphasis to coordinate performance and analysis of different project within ECOCHANGE. The partners have different roles in the environment and data were therefore exchanged between the organizations. We are now in the stage of data compilation, analysis and publication of the data obtained within the ECOCHANGE program. In collaboration with the strategic research environment BEAM, we planned for a joint special report on Baltic Sea ecosystem-based management in an era of climate change. National and international collaboration and net-working were further developed. External funding for ECOCHANGE related research was applied for. 69 (175)
Meetings between ECOCHANGE researchers and the reference group were arranged to discuss research results and assessment of environmental state in the Baltic. A strategic research agenda and vision for the future were developed. Our research environment prioritized teaching interdisciplinary marine science on the basic and advanced academic level, as well as on PhD and post doc levels. We also contributed to an in-service training program for high school teachers, and to outreach activities for school children. We put emphasis to update a publication plan for ECOCHANGE research, by collaboration with information officers at the Universities. Knowledge transfer were performed through scientific and popular publications, giving interviews about research results. Presentations of ECOCHANGE research results were performed to a broad range of organizations; e.g. the academia, environmental organizations and media. ECOCHANGE researchers contributed to the revision of a European research agenda for the Baltic Sea." Please describe the major activities within the environment in 2013. (Question Q2) Research, Research relating to all 5 thematic areas was carried out. Theme 1: Experiments were performed to study how a freshening of the Baltic, i.e. decreased salinity, would affect the growth and community composition of heterotrophic bacteria and cyanobacteria. The temporal and spatial variation of plankton and fish in the Baltic proper were analysed. An experiment was performed to disentangle the effect of light attenuation and nutrition of terrestrial dissolved organic matter on bacterial and phytoplankton growth. Theme 2: Studies on the influence of wet-lands on pike recruitments were compiled and published. Interactions between three-spine stickleback and perch were studied. Long term effects of increased temperature and terrestrial dissolved organic matter on ecosystem productivity, fish population dynamics and production are studied in a large scale experimental system. Effects of terrestrial organic carbon on light dependent winter consumption and winter mortality in fish were studied in a large scale experimental system. Effects of presence/absence of top predators (trophic cascades) on CO2 emissions and net ecosystem production were studied in large scale experimental system. RNA/DNA analyses of zooplankton and threespine stickle back were performed. Theme 3: A method to analyze sorption of organic pollutants to dissolved organic matter were developed. The effect of increased temperature and terrestrial dissolved organic matter on the distribution of organic pollutants were studied in a mesocosm experiment. Theme 4: The spatial and temporal variation of phytoplankton and physical-chemical parameters were investigated in estuaries from north to south of the Baltic Sea, in order to develop a strategy for the design of coastal monitoring programs in relation the influence of land and offshore drivers. Theme 5: A theoretical study on the effect of colored terrestrial dissolved organic carbon on marine ecosystem productivity was performed. Mechanisms governing population dynamics in the benthic community in the Baltic Sea were studied. We performed teaching on many different courses at the basal and advanced academic level. For example, a course in Aquatic ecology 15 hp was held. PhD students were supervised and PhD courses given. Outreach activities were strengthened during 2013, and we gave interviews about research results, seminars and published popular scientific papers. In collaboration with the strategic research environment BEAM, we 70 (175)
planned for a joint special report on Baltic Sea ecosystem-based management in an era of climate change to be published in AMBIO. A meeting between the reference group and ECOCHANGE researchers were arranged to discuss results and research priorities. Two steering board meetings were held to discuss and decide about ECOCHANGE research strategies. Please describe the major results within the environment in 2013. (Question Q3) "Theme 1: Climate change scenarios for the Baltic Sea predict an increase in temperature and precipitations together with low evaporation, resulting in more DOM-rich and less saline waters. To study how this may affect the base of the food web, we performed experiments to determine the bacterial response to transplants between humic impacted seawater (Bothnian Sea) and relatively transparent seawater (Baltic Proper). Bacteria responded significantly to the cross-transplant in terms of bacterial production and enzymatic activity (specifically betaglucosidase activity). Metabolic activity of both communities showed that bacterial growth efficiency was lower in transplants to marine seawater compared to humic impacted seawater (Bothnian Sea). Bacteria in transplants to humic impacted water actively utilized terrigenous carbon while bacteria transplanted to Baltic proper were not as active, indicating that more energy is used for heterotrophic bacterial production in marine bacterial communities growing on terrigenous carbon. Taken together shifts in bacterial community were more apparent when marine bacteria were transferred to humic-rich seawater. Blooms of filamentous cyanobacteria are a recurring event during the summer months in the Baltic proper; and Nodularia spumigena can produce nodularin, a hepatoxin that is a threat to both human and animal health. Optimal growth rate for N. spumigena is at salinity 7 and at 25 C. For the predicted scenarios (salinity <7, 21-22 C), the growth response of this cyanobacterium was significantly below optimal conditions at salinity 3 after 10-20 generations. However, the gene encoding for nodularin was still expressed regardless of sub-optimal salinity, suggesting that salinity is not a main driver in the toxin metabolism in N. spumigena. After 100 generations, a significant change in morphotypes at different salinities was apparent, indicating that N. spumigena has a highly adaptive potential. Nearshore and offshore marine pelagic systems are associated with marked differences in primary (PP) and bacterial production (BP). PP and BP are considered to decrease along a nearshore-offshore gradients, coupled to the transfer of nutrient-rich terrestrial and riverine matter including dissolved organic carbon to coastal waters. Our studies show that it is not necessarily the case after the spring bloom in the Baltic Proper. We found that the primary production instead increased from nearshore to offshore areas during the summer. Although this increase showed high variability it started prior to the summer cyanobacterial bloom and thus, it may be coupled to upwelling of nutrient rich water in some of the offshore areas. BP was coupled to PP although its relative proportion (BP:PP) increases along a nearshore-offshore gradient. We found the BP:PP ratio to be higher, 50-20%, than previously reported for the Baltic Proper, 5%. Climate scenarios predict significant warming of the Baltic Sea, which will prolong the growth season, but also affect the structure of the microbial food webs and C export to higher trophic levels. Theme 2: We have earlier shown that that three spine sticklebacks can have strong negative effects on perch recruitment via predation on larval perch and identified size dependent threshold levels when sticklebacks have strong negative effects on perch recruitment (Two manuscripts are in prep reporting these results). In order to understand mechanism behind the observed increase in sticklebacks, we estimated the size- and temperaturedependent attack rate and the critical resource density (CRD) of three-spined sticklebacks. We incorporated laboratory results with time series of zooplankton abundance to estimate historical trends in degrees of resource limitation in sticklebacks and evaluate if increases in individual consumption rates could be a plausible mechanism facilitating the suggested population increase. Attack rates increased with body size and temperature in laboratory experiments. Estimated CRD increased with size but decreased with temperature, 71 (175)
suggesting that stickleback scope for individual and population growth might increase at temperatures above 15 C. Our results further suggest that sticklebacks have been living closer to maximum consumption capacity in the coastal areas of the Bothnian Sea (BS) and Bothnian Bay (BB) and experienced decreasing levels of resource limitation in the corresponding off-shore zones which may have facilitated increases in stickleback densities for these areas (published early on line JEMEE dec 2013). Long term experimental studies in the large scale experimental ecosystem facility (EXEF) show: 1) Negative effects of terrestrial organic carbon on light dependent winter resource consumption and over winter survival in fish. 2) Presence of piscivores (four level food chains) caused strong pelagic trophic cascades with increased carbon dioxide emissions compared to three level food chain with planktivores as top predators. Similarly, piscivore induced trophic cascades reduced net ecosystem production (NEP) compared to NEP in the three level food chain. Habitat specific net production estimates and herbivore biomasses suggests that the observed responses in CO2 emissions and NEP was mainly driven by top predator induced trophic cascades in the pelagic system. 3) In clear water systems increased temperature had no effect on whole ecosystem primary production but negatively affected benthic and pelagic primary consumer biomass. Fish population density and maximum size decrease with temperature whereas proportion of young and smaller-sized fish increased. Our result support the hypothesis of decreasing body size with increased temperature and suggest that in fish populations, global warming may increase competition, favor small size classes which in turn may destabilize population and community dynamics. 4) Pelagic gross primary production (GPP) is negatively affected by warming but enhanced by humic water input, which contained nutrients and DOC. Thus, owed to increase GPP, pelagic NEP was positive in humic treatments despite light reduction. Benthic GPP are negatively affected by increased temperature but also by humic input, but no statistical effect was observed on benthic NEP. When considering whole ecosystem metabolism no effects of the treatments were observed on NEP, implying that the effects detected in the pelagic were counteracted by opposite trends in benthic compartments. Thus, this study emphasizes the importance of including all possible compartments when analyzing the response of aquatic ecosystems to climate change since conclusions based on one single habitat (e. g. pelagic) may potentially lead to wrong predictions at the whole ecosystem level. (All four studies are in prep). The studies on coastal fish of freshwater origin in Baltic Sea have continued. As a base, the genetics (microsatellites) for different populations (e.g. pike Esox lucius) is studied in relation to population characters. We found that the GSI (gonadal to somatic index), the fecundity and vertebrate count differed between populations. We further showed that juvenile growth rate differed for different populations (shown in common garden experiments in the laboratory). The results indicate that fish (populations) adapt to spawning areas of different character, changing individual traits. Theme 3: During the year, studies of the association of organic pollutants to dissolved organic matter (DOM) have continued, including field, mesocosm, and laboratory studies. During summer 2013, an extensive mesocosm experiment was conducted investigation the effects of increased DOC and temperature on the contaminant distribution in a simulated complex and due to the drivers shifting the ecological system. The results will be processed and reported during 2014. Results from the previous developed model system for studies of sorption of organic substances on DOC, based on measurements of reduction in the freely dissolved fraction of pollutants upon addition of environmentally relevant amounts of DOC (low mg/l levels), has been complemented by field data, based on frequent sampling (Ferry Box) in the gradient South to North, covering all three basins of the Baltic. Preliminary results indicate, basin specific interactions between DOC and a multitude of organic anthropogenic compounds. New data on organic pollutants from the 2012 sampling campaign, using integrated passive sampling (SPMD, POCIS and DGT samples) in the three basins of the Baltic Sea, reveal that some pharmaceuticals (e.g.carbamazepin, orfenadrin, flecainid) can be frequently detected in sea water and in some cases (viz. 72 (175)
carbamazepin), in all samples (and at three depths) in all three basins of the Baltic Sea. In addition, samples of zooplankton and fish collected at the same locations are presently analyzed for additional selected contaminant (e.g. PCDD/Fs, PCBs, HCB and PBDEs). Further, results for air-water gas exchange of chlorinated pesticides (e.g. chlorpyrifos, chlorthal dimethyl, trifluralin, chlorothalonil, endosulfan) in Bothnian Bay have been finalized, also putting these results in perspective with the bulk atmospheric deposition loadings (also including non-bde flame retardants e.g. Dechlorane Plus, TBECH, BTBPE) determined as atmospheric deposition of persistent organic pollutants and chemicals of emerging concern at two sites in northern Sweden. Furthermore, the first measurements of brominated anisoles in air and water of the Baltic Sea and estimation of air-water gas exchange has been performed. A FORMAS funded spin-off project was launched during 2013 focusing on the possible re-activation of contaminants from fiber banks and fiber-rich sediments originating from the pulp and paper industry effluents along the coast of the Bothnian Sea. Studies of fluxes and pathways for release from the sediment and transfer into the food web are initiated, including a field sampling campaign the fall 2013. Related to this project is new publications on mercury biogeochemistry in marine environments as well as time trends and source identification of PCDD/Fs in Baltic Sea sediment core samples. Theme 4: A modelling tool box was applied to design a monitoring program in a coastal area in the northern Baltic Sea that is profoundly influenced by river run off, the Öre estuary (Bothnian Sea). Temporal and spatial field data on chemical, physical and biological parameters, measured within the ECOCHANGE program, were used as a base in the model work. Similar studies are planned for coastal areas in the Bothnian Bay (Råneå estuary) and the southern Baltic Proper (Emån estuary). The aim is to develop a general strategy for design of monitoring programmes, based on the morphometry. Field measurements with a logging sensor buoy system (Aanderaa SeaGuard) were performed between June and December 2013. One sensor was permanently moored at a fixed station, while another mobile SeaGuard was used on 26 occasions to make synoptic measurements within a few hours of 21 stations in a grid over the Öre Bay. Measured variables include temperature, salinity, photosynthetically available radiations, chlorophyll fluorescence, oxygen, CDOM, turbidity and wave height. In addition, 47 chemical chlorophyll-a measurements were made simultaneously with the sensor recordings. The huge amount of data (540 profiles) will be quality assured and organized for statistical analysis. Results will be reported in scientific articles during 2014. Data will be evaluated focusing on the control of biological variables (i.e. chlorophyll-a) by the physical and chemical ones. An analysis of spatiotemporal sampling design to achieve desired statistical power will be done in collaboration between Umeå University and The Museum of Natural History. Theme 5: A theoretical study on the effect of terrestrial coloured dissolved organic carbon on the productivity in coastal areas with different nitrogen and phosphorus availability was performed. Outcomes of the model simulations showed that additions of coloured dissolved organic carbon in general caused an increase of bacterial production and a decrease of primary production, and that the production at higher trophic levels decreased due to the establishment of an intermediate trophic level. The system became net heterotrophic. However these effects was more pronounced at low NP availability, which would translate to the conditions in the northern Baltic Sea where nutrient concentrations are low and inflow of terrestrial dissolved organic matter high. During the last two decades considerable changes of the benthic fauna have occurred in the northern Baltic Sea, the Gulf of Bothnia. The native amphipod, Monoporeia affinis, has shown a large scale abundance 73 (175)
decrease, while polychaetes, Marenzelleria spp. have invaded the system. It may thus be hypothesized that this change was caused by a competitive advantage of Marenzelleria at low resource availability, i.e. as is the condition in the Gulf of Bothnia. We tested the competitive advantage of Marenzelleria and M. affinis in an experiment with high and low fresh phytoplankton food supply. When exposed to high food supply both species showed stable or increased biomass over the four week test period. In low food supply, however, M. affinis was found to have a competitive advantage.monitoring data from the Gulf of Bothnia show that the decrease of M. affinis during the period 1998-2001 coincided with a marked decrease in primary production, suggesting that that the amphipod decrease was caused by food resource limitation. Combining monitoring and experimental data suggests that the invasion of Marenzelleria did not cause the decrease of M. affinis in the northern Baltic Sea; it rather took advantage of the density gap that had occurred. The study is relevant from a climate change perspective, since the decreased primary production during 1998-2001 was caused by increased precipitation and inflow of allochthonous dissolved organic carbon. Future climate-induced increases in precipitation may thus have a negative effect on the growth of benthic organisms in the northern Baltic Sea. Publications and outreach activities: Research achievements within the environment have been published in scientific peer review journals and popular scientific journals. We have presented research results at scientific conferences and given seminars to governmental, municipal and environmental organizations. Outreach activities directed to the general public and private sector have been carried out. Teaching: Teaching marine science has contributed to bachelors and master exams at the participating Universities. The supervision of doctoral students within the environment has resulted in 8 completed PhD s." 74 (175)
8. Strategiskt forskningsområde: Hållbart nyttjande av naturresurser Huvudansvarig myndighet: Samrådande myndighet: Vinnova Formas År 2010 2011 2012 2013 2014 Total budget 20 30 50 50 50 Avsättning till infrastruktur 1 1 2 2 2 Budget efter avsättning 19 29 48 48 48 8.1 Sustainable use of mineral resources securing the future Huvudsökande: Luleå Tekniska Universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 21 663 008 Personell 11 016 510 Co funding from main applicant higher education institution 0 Running costs 3 109 012 Co-funding from-co-applicant higher education institution 0 High cost Equipment - Funding from collaborating research institutes 0 Infrastructure running costs 1 675 135 Funding from other collaborators 0 Other costs 5 862 351 Other external funding 0 Totalt: 21 663 008 Totalt: 21 663 008 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. We have choosen not to include other funding to the general research environment in our financial reporting. Please state the main priorities within the environment in 2013. (Question Q1) "The work within the six work packages defined already from the start has continued and many promising results are now available. The priorities have been to continue to develop the research within the work packages, while at the same time and a lot of efforts have been invested in securing leverage and develop CAMM both on a national and international basis. The latter has been the main focus for the management of CAMM during 2013. The latter work has been extremely successful and is described more under Q2 and Q3" 75 (175)
Please describe the major activities within the environment in 2013. (Question Q2) "The management of CAMM was during the first half of 2013 increased by deputy director S&T, ass. professor Jenny Greberg (starting 20130301) and deputy director public affairs Sabine Maier (starting 20130401). This reinforcement of the management will lead to an increased activity within CAMM for outreach and leverage. The main focus has been on developing a strategic agenda for the mining and metal producing industry (STRIM) in response to a call from Vinnova for strategic innovation agendas. In relation to this the CAMM management has been operational in defining a RDI program (SIO) for the same area. This was submitted to Vinnova in March 2013 Management has also been continuously involved in the work to establish an international consortium in response to a future call for an EIT KIC within raw materials. Sweden is leading the work on primary resources in the EIT KIC RM consortium Raw MatTERS. CAMM was also involved in developing the ERA-MIN roadmap where director Pär Weihed has been responsible for the agenda for primary resources. A first pilot call was released in April 2013. CAMM has also been involved in the work to develop a strategic innovation plan (SIP) within the European innovation partnership on raw materials, with experts in operational groups 1 and 3. A call for commitment was opened in December and it is anticipated that many Swedish organizations will be included in different commitments. Deputy director Sabine Maier and director Pär Weihed have also been involved in the establishment of the NordMin network of excellence, based at and managed by LTU. Calls for Nordic collaboration within metals and minerals were launched in December 2013. CAMM management will also manage the LTU strategic research and innovation area Mines of the Future (Framtidens gruvor). This will enable CAMM to develop further with integration also of non-technical research areas that are strong at LTU. This also fits well with the CAMM strategy and enables a future widened scope of CAMM. The six work packages have been in full operation and generate a lot of interesting results. These are all described under Q3." Please describe the major results within the environment in 2013. (Question Q3) "After an evaluation of the SIO STRIM proposal this program was one out of five that was accepted to start in 2013 by Vinnova. The budget for the three-year program working at higher TRL levels compared to the SFO is close to 200 MSEK. The Swedish mining and metal producing industry in the SIO STRIM suggested that the CAMM management would also form the management of the SIO STRIM program. This is a direct leverage of the SFO CAMM. During the second half of 2013 the work with SIO STRIM management was intensified and several meetings with Vinnova and the supporting organizations were held. The first major call for proposals was opened January 31st 2014. A short summary of major results per work package is given below: For work package 1 the ore characterization of the Rockliden VMS mineralization continued with the evaluation of the drill core samples collected last year in order to do a mapping of the Rockliden mineralogy and a definition of different ore types of the Rockliden deposit. EPMA/WDS analyses on the silicate and oxide mineralogy in the ore material from the Rockliden massive sulphide deposit were performed, materials were collected for new flotation tests and crushed material was sent for geochemical analysis. A licentiate thesis on this work was presented Dec. 16th 2013. 76 (175)
The PhD project of Cecilia Lund on Geological and process mineralogical study of the Malmberget iron ore was completed during spring. The academic dissertation took place on 6th of September 2013. Within the investigation of ore comminution behavior systematic test have been conducted for a series of ore samples of different mineral texture taken from LKAB s Malmberget mine. Quantitative results were analyzed with respect to correlations between mineralogy and mechanical properties and resulted in empirical models. Drop weight tests of different ore samples were conducted at Technical University Berlin in April. The results from these initial tests are very promising and will be extended towards more systematic test series. Grindability tests have been conducted with the Malmberget samples. Laws for downscaling the grindability test are now under development. Modeling has been conducted to support the grinding test downscaling procedure and to describe grinding results a function of modal mineralogy and texture parameters. A study on LKAB s ores has been completed during Q1 and Q2. The purpose of the study was to test whether the combination of XRD and XRF analysis could be used for high-quality mineral quantification (modal analysis) and whether the technique could be automatized. As a result of this study the combined method of XRD Rietveld and XRF is suitable for modal analysis of LKAB s samples. The project Defining, Establishing and Piloting of Geometallurgical Model and Simulation Framework for Iron Ores continued with the conceptual design of the framework and the planning for the process sampling at Kiruna KKA3 concentrator. Full-scale process sampling was also conducted with support from LKAB personnel. Collaboration with the Kemi-Tornio University within the Green Mining program (Tekes, Finland) was initiated. Lab-scale experiments have been conducted with the aim to determine distribution of minor elements in several different copper concentrate during roasting. Work is on going to characterize the samples before and after roasting experiments. The development of the roasting model (SimuSage) is progressing. Thermodynamic simulation of metallurgical processes continued with building models to simulate different unit operations using SimuSage. A copper converter model has been verified with respect to the key elements. Work has been focused on inclusion of minor elements, antimony and bismuth into the model. A licentiate thesis dealing with the development of a thermodynamic process model was presented on December 9th of December 2013. A large sampling campaign was prepared and conducted during excavation of an industrial smelting furnace. The sampling period extended from tapping of the melt before closing down the furnace, though excavation of the furnace. The evaluation of results will be the base for a process model of the smelting unit. In work package 2 a numerical model of the Kiirunavaara hanging wall has been constructed. Within the project Ground deformations around the Malmberget mine a rock mass characterization study has been carried out. Preliminary numerical analyses have started. A feasibility study of the Kiirunavaara footwall has started. This work has focused on collecting and summarizing the data and knowledge gained from studies in the past and to identify gaps in the knowledge, which need to be studied in detail. The first part of the footwall stability project has been focused on collecting data, identifying missing information and preparing for a fieldmonitoring program. This has been done by numerical analyses of the footwall. 3D numerical analyses of the ground surface deformations around the ore bodies in Malmbeget have started. Sixth large-scale dynamic tests of rock support systems were carried out. The results were promising. Within the sub-project the evaluation of mining sequences of a complex ore body, using a probabilistic approach three new studies have been decided: (i) a room and pillar mine (using Laisvall data), (ii) a stope in the Kristineberg mine and (iii) a Serbian mine case. The projects Analysis of the mining induced seismicity at the 77 (175)
Kiirunavaara mine and one feasibility study Automatic classification of seismic events have started. One PhD students Andreas Eitzenberger defended his PhD thesis Wave Propagation in Rock and the Influence of Discontinuities in Oct. 19th 2013. Numerical analyses of potential laboratory testing of rock support under dynamic conditions have been done. An investigation of new principles for rock support testing has been carried out. This resulted in a concept solution, which needs more investigations in order to be feasible. Weak ground or non-violent failures Numerical analyses of the Kristineberg test site has been done as well as conceptual analyses of the Kristineberg and Malmberget mines. The final analyses of the field data from Kristineberg were also carried out. Blasting and fragmentation The activity during Q2 has mainly been within detonics. The main activities have been development of new measurement methodology for field monitoring of detonic properties during non-ideal detonation, planning of field tests and initiated cooperation with Leeds University using the result from their detonation models. Two new big research projects have been granted: (i) BeFo: Analysis of the extension of the damage zone and how it depends on the geology - and (ii) Vinnova: Face to Surface (SIO STRIM). In work package 3 research was continued and carried out in the subjects of mining Production Assurance Program (PAP), Remaining Useful Life (RUL), Rock and machine interface, and integration of mine working environment into production systems. In the subject area of PAP, research was continued to establish and find out the PAP s strength and weaknesses as the output of previous study states that the PAP is more adaptable technique for mining industry. In the next step some data will be gathered from mining industry for the process detailing and will focus on revealing the bottleneck operation in mining industry. The research will continue to explore how to establish a production system model to locate bottlenecks and identify the areas of improvement, and also which uncertainties are linked to the bottleneck operation (uncertainty formulation). In parallel, several production analysis methods such as linear and nonlinear programing, goal programing, six sigma, regression analysis etc. have been studied and finally the System Dynamics (SD) modeling method has been selected for production analysis in mines. The simulation approach, which is applied in SD provides a good opportunity to pass the complexity of the system. Studies were also done to define the most important input parameters, which are needed for model building in SD. Also, the related software package Vensim which will be used for the simulation process was being studied and practices are still in progress. Concerning the RUL (Remaining Useful Life), the research was being continued and developed. The developed neural network model for prediction of RUL on grinding mill liners in Boliden mine was improved and for generalization, the study of new approaches for estimating RUL in combination with failure mechanisms, such as meta-heuristic algorithms is also being studied. A comprehensive study on RUL estimation methods is also carried out. In the field of rock and machine interface and understanding/communicating rock mass behavior in real time; focus is on rock drilling technology. Drilling is the basic technology in many of the mining operations. A large number of data (for four drilling rigs) from Boliden Mineral Aitik Copper Mine was gathered. An algorithm was 78 (175)
made, updated and run by MATLAB. In the subproject of the integration of mine working environment into production systems work on laws, provisions and other relevant regulation as well as safety statistics and ways to work safe and manage risks has been the main activities. The project Effektivare SAMverkan (More efficient Co-operation) focuses on improving health and safety for contractors working in LKAB mines was started. Work continued in work package 4 on characterization of magnetite and bentonite by atomic force microscopy (AFM). Final work on an in-situ ATR-FTIR study of the adsorption of linear alkylbenzene sulfonate at the iron oxide/water interface and effect of ph and co-sorbing inorganic ions was done. Work on rare earth dithiocarbamates and multinuclear solid-state NMR and DFT calculations were initiated. A licentiate thesis entitled Sulphide Mineral Flotation: A New Insight into Oxidation Mechanisms was presented on 4th June 2013. A project on titanium phosphate adsorbents was granted from Formas. Work together with scientists from Russia has started looking for funding to build a pilot plant for silicon production by a new method. Results from work on adsorption of dodecylbenzenesulfonate and primary alcohol ethoxylate surfactants on iron oxides for applications in mineral processing, enhanced oil recovery, and detergency was submitted for publication. Mefos has applied to the Swedish energy agency for funds for a project on CO2 separation from blast furnace gas with Hedlund as co-applicant. Studies on the formation of hydrogen peroxide (H2O2), an oxidizing agent stronger than oxygen, by sulphide minerals during wet and dry grinding have been performed. It was found that pyrite (FeS2), chalcopyrite (CuFeS2), sphalerite ((Zn, Fe) S), and galena (PbS) generated H2O2 in pulp liquid during wet grinding and also when the freshly ground solids are placed in water immediately after dry grinding. Experiments on synthesizing novel mineral specific collectors having one alkyl chain but with two head groups are also undertaken. Relation between adsorption behaviour of a given surfactant on a specific mineral surface and its molecular structure over a range of concentration and ph values, and region of maximum recovery were established. DFT calculations on PbDTP complexes for investigation on how intermolecular forces affect 207Pb NMR chemical shift tensors started. In work package 5 within the subproject remediation of mine waste deposits, and prevention of formation of ARD research has been carried out on geophysical investigations of the back-filled open pit at the Kimheden mine site as well a study on the Fe2+/Fe3+ balance in drainage water at the same mine. A project on solidification of tailings using ash and cement started while a study on degradation of sewage sludge was concluded. A feasibility study regarding paste disposal of tailings was initiated with funding from Boliden, LKAB and Outotec. A feasibility study Using residual products for prevention of sulphide oxidation in reactive mine waste funded by Boliden and Vinnova started and the ERA-Min project Sustainable and responsible supply of primary resources, coordinated by GTK in Finland was granted. In the subproject on construction of mine dams a study started on the thermal balance and potential for permafrost in tailings deposits in sub-arctic regions. Aitik is used as a case. Laboratory work regarding mechanical properties of tailings sand has started based upon samples taken in Aitik deposit. The focus of the 79 (175)
study is to evaluate the impact of grain shape on mechanical properties of tailings. The grain shape and angularity is hypothesized to be key parameters for mechanical properties of tailings. Final work on numerical analyses for seismic behavior of an upstream tailings dam was done and reported during the year. A PhD was defended on June 13th 2013 on numerical analyses of stability of a gradually raised tailings dam. Work on dust reduction and dust measurements around mining areas was initiated in Aitik. A laboratory study of particle shape of tailings has started. The particle shape will be related to strength properties of tailings. Next step is to have a picture of the degradation of tailings particles in order to find long-term changes of strength properties of tailings. Having this long-term behavior of tailings dams can be assessed (compare pullet point no 2). Laboratory work regarding mechanical properties of tailings sand is ongoing. In the subproject on natural metal release in mineralized areas a study of the possibilities to use nitrogen isotopes as a tracer for nitrogen transformations in the mineral processing plants at Kiruna is ongoing. Collaboration and exchange between Sweden and Finland related to nitrogen discharges at mine sites is developed. This exchange is related to the Finnish research programme Solutions for Control of Nitrogen Discharges at Mines and Quarries (MINIMAN). Experimental and analytical work related to the bioleaching of chalcopyrite in cooperation with the Division of Sustainable Process Engineering, LTU. Work on interpretation of Cu and Fe isotope fractionation in biofilms, and the experimental and analytical data from the bioleaching of chalcopyrite is ongoing, A SIO STRIM project, "Reduction of nitrogen discharges in mining processes and mitigating its environmental impact mining", related to nitrogen from mining was approved for funding from Vinnova. Development of analyses for Cd-isotopes and the use of these isotopes to trace the source of Cd pollution is a new project that started. This project is related to the question of natural background levels. In work package 6 the subproject Iron carrying raw materials for future blast furnace ironmaking routes several new projects were developed. As the availability of good coking coal is decreasing on the market, there is an increased interest to study alternative coke blends. This is done in a new project FLEXCOKE at Swerea MEFOS that started in July 2013 with funding from RFCS and CAMM. Another new RFCS financed project carried out within CAMM is the IMPCO project, coordinated by Swerea MEFOS, aiming to improve the combustion and conversion of injected PC. This includes modified design of the injection lance used at SSAB, investigation on thermal behaviour of coals and studies on parameter settings. Tests are to be conducted in laboratory, in technical scale at the LKAB EBF and at BF No. 3 at SSAB and theoretical tools as CFD, Factsage and thermodynamic calculations are used in experimental design and evaluation. The first part of the CFD modelling for improved dispersion of coal plume showing a positive effect from a swirl-tip lance with high gas velocity of cooling gas in the coaxial gap is finalised. Technical scale tests for studies on the dispersion of coal plume have been conducted and will be used as validation for CFD modelling of lance design. Image analyses and modelling starts in January as a master thesis work. A modified lance for one-tuyere performance test will be manufactured and installed in January together with raceway depth measurement and camera. The reaction behaviour during volatilisation, combustion and gasification was studied for different types of carbonaceous injection materials in a master thesis by Adeline Morcel. Earlier started research on the use of residues and biomass in CCA has continued. The research on activation of nut coke and on the use of Lc values for coke to determine the thermal history of the coke, have been finalised. Further SEM studies on the activated coke to understand the addition of activation compound will be conducted. Successful pilot-scale tests in the LKAB experimental BF were conducted with two types of activated nut coke and samples as well as data are almost finally evaluated. In the subproject Iron carrying raw materials as scrap substitutes work was mainly carried out within n the project Energy efficient recycling of in-plant fines in rotary hearth furnace (RHF), financed from the Swedish Energy Agency through Jernkontoret and CAMM. The intention is to produce agglomerates containing residue materials, which after reduction in e.g. a rotary hearth furnace will give a reduced material that can serve as a scrap substitute. 80 (175)
Characterization and reduction studies of briquettes made out of blends of steel waste materials have been continued. Effect of N2 flowrate as well as heating rate on carbon consumption, mass loss and metallization degree of waste materials containing briquettes are studied. Reduction behaviour of iron and steel making waste materials containing cold bonded pellets (made by SSAB) was studied by means of TG/DTA/MS. Phase development during heating and reduction progress was also studied by XRD of quenched samples. The compressive strength of produced pellets was measured for green, partially fired as well as completely fired pellets. Swelling, deformation and melting of the produced pellets were followed by heating microscope. Tests with addition of pre-treated briquettes into the desulphurisation plant have been conducted. Collected data and samples have been evaluation. Basket samples of cold bonded pellets with and without heat pre-treatment were added to the LKAB experimental BF and the collected samples have been evaluated. The project, SMAREC (SMArt RECycling of Residues from ore based steelmaking), will be carried out in collaboration between LTU, Swerea MEFOS, SSAB EMEA, SSAB Merox and LKAB. Finally in the subproject Zero waste steel production emphasis has been on high resource efficiency, which requires that all waste and residues are turned into products, i.e. zero waste production. This involves a high degree of recirculation of iron bearing residues and environmentally friendly utilization of all by-products, and includes slag products, dust, sludge, mill scale etc. Although some slags are used to large extent, there is still a long way to go before all slag products have a secure market. One of the limitations for the use of slag is the metal content and the possibility for leaching of these metals. Lack of a suitable process step for recycling iron bearing residues at 100% pellet operation, will necessitate an extended use of new technique and process steps as e.g. briquetting/pelletizing, injection and Rotary Hearth Furnace processing. Since late 2012, a new project on the use of slag as raw material in cement production, Increased use of by-products and waste from steel industry in cement production, is carried out with financing from Mistra. Activities on characterisation of reaction mechanisms in CCA, study of mineralogical influence on the leaching of metals from slag and characterisation of residues from ore based steelmaking for use as raw material in cement production are ongoing and proceeds according to plan. Two research applications to the Swedish Energy Agency, connected to residue minimisation and recycling in the ore based steelmaking have been approved. One is Investigation on Increase of Flue Dust in Fully Pellet Charged Blast Furnaces. For one of the applications, Smart recycling of residues from ore based steelmaking, LTU is the responsible applicant, see also text in section B above. 81 (175)
8.2 Forests and other plants Huvudsökande: Sveriges Lantbruksuniversitet 80% Medsökande: Umeå universitet 20% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 26 600 000 Personell 12 263 152 21 100 000 Running costs 9 426 960 Co-funding from-co-applicant higher education institution 3 400 000 High cost Equipment 133 436 Funding from collaborating research institutes 1 100 000 Infrastructure running costs 2 193 164 Funding from other collaborators 0 Other costs 0 Other external funding 72 000 000 Totalt: 24 016 712 Totalt: 124 200 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. As described in the original application, one aim with the SFO is that activities within TC4F should be closely connected to other large projects. Below is a list of the main projects and programmes with which TC4F is interacting: - Strong research environment 5 msek from Formas - The Berzelii Center of Forest Biotechnology (VINNOVA/VR) 10 msek from VR/VINNOVA + 10 msek from UmU and SLU - Future Forests 8 msek (out of 34 msek) from MISTRA and from the forest sector (forest companies) - ICON (Industrial Crops producing added value Oils for Novel chemicals) 2 msek from EU-FP7 - Spruce genome sequencing 15 msek from the Wallenberg Foundation (KAW) - Parasite Resistance Trees 4 msek from SFF - Mistra Biotec 10mSEK from Mistra and 10mSEK from SLU - Biorefinery Öresund 8 msek, half from involved universities and half from EU Please state the main priorities within the environment in 2013. (Question Q1) The overall main priority for 2013 of the environment is to have the strategic research initiative fully up and working which means; - That all recruitments of young scientists (doctoral students and post-docs) are done and that they have started working and are taking advantage of the strong research environment that this research initiative contributes in building. 82 (175)
- That PIs within the research initiative know each other and can take advantage of other strong colleagues and equipment and facilities present within the strong research environment. - That joint projects and increased collaboration has led to increased number of publications in high ranked journals of researchers within the strong research environment. - That increased international collaboration has developed and is continuously developing including researchers within the strong research environment and, - That increased contacts and collaborations with industrial partners of relevance for the strong research environment. The research and other activities within the strong research environment is carried out within four themes, i) Impact of climate and nitrogen on carbon dynamics in forests ii) Forest genetics and the next generation of forest trees, iii) Sustainable and adaptive forest management and iv) Other renewable plant resources, nonfood crops, each with their own main priorities of 2013; Theme 1 To use large scale experiments in evaluating the consequences for forest growth of altering C-N interactions in forests. To establish the impact of altered C-N status on tree molecular physiology, integrated with the community dynamics of the trees epiphytic and soil microbial populations. Theme 2 To analyze and publish the Norway spruce genome sequence. To develop Norway spruce as model system for genetics and physiology. Theme 3 To evaluate ingrowth of new regeneration and stand management in continuous cover forests.to evaluate long term effects of regeneration intensity.to evaluate establishment and stand management of fast growing broadleaved trees. Theme 4 To establish metabolic engineering of plant oil in seeds and vegetative tissues. To understand relationships between structures and functions of bio-based materials. Please describe the major activities within the environment in 2013. (Question 2) "The major activities for 2013 of the environment have been connected to the main priorities of the environment for 2013 which means; - That the newly recruited young scientists (doctoral students and post-docs) have been introduced to the strong research environment and have started working together with the PIs and have been given the many opportunities that such a strong research environment can contribute with. - An international PhD-course was given during 2013 with 30 participants from the whole world, where a number of doctoral students and teachers from this research environment participated and with co-funding from the research environment. - That PIs within the research initiative have met both within the steering committee of the program to discuss and plan the work and priorities of the research environment but also in meetings for all the PIs within e.g. a theme. The latter is specifically important for Theme 4, where the PIs in the program are spread over four campuses. - The first joint publications from collaborations between different themes and with authors from different campuses within the research environment (where no collaboration was present before this research initiative) was published during 2013. Furthermore, both Science and Nature publications have come out as a result of this research initiative.. 83 (175)
- An increased number of international collaborations could be seen from the research environment from 2013 also resulting in a number of publications together with international research groups where collaboration did not exist before this research initiative and, - An increased number of doctoral students and younger researchers with collaboration, co-supervision and co-funding from this strong research initiative and from industrial partners were seen in 2013. Major activities for 2013 from the different themes were; Theme 1 1. Measurements of Carbon and Nitrogen and water fluxes in conifer forests have been carried out utilizing the Rosinedal, Flakaliden and Åheden field sites. The impact of N-deposition and N-fertilization on these allocation patterns and the potential of these stands for biomass production and carbon storage have been investigated. At the Kulbäcksliden field site, the fourth and final year of a project aimed at understanding how nitrogen fertilization changes the way spruce stands allocate fixed carbon under field conditions was completed. 2. To perform measurements of soil N turnover and fluxes in fertilized and unfertilized forests, two new methods have been developed; one to assess the impact of tree transpiration on soil nitrogen fluxes, and the second one for reversible reduction of phloem carbon transport. 3. Application of new high-throughput methodologies to field experiments through integration of our ecological and physiological studies with the latest molecular techniques by examining seasonal changes in gene expression in spruce roots at the experimental sites at Flakaliden and Kulbäcksliden. These experiments incorporate low and high nutrient sites in addition to experiments that compare the effect of N-supply to the soil verses direct supply to the canopy via the stem transpiration stream. These study have been expanded to also include shoots/needles and vascular cambium, to provide a complete picture of the long term response of spruce trees to added nutrients over the course of a growing season. The soil metagenomic community diversity and tree ecto-/endophyte diversity are also profiled over the same season to see the response of fertilisation on soil and ecto-/endophyte communities. 4. Modelling is applied to prepare for discussion of a new theoretical/conceptual framework for evaluating the potential impact of genetic modifications on whole tree and forest stand productivity. Theme 2 1. The sequence of the Norway spruce genome has been generated and analysed. This is the largest genome sequenced all categories, and we use the data to draw conclusions about genome evolution in conifers in general, and in conifers in particular. We also produced large mrna and srna datasets, analysed repeats in detail and produced draft genome sequences of five other conifers, Pinus, Abies, Juniperus, Taxus and Gnetum. This activity resulted in a full-length articla in Nature with only Swedish first and corresponding authors. 2. We have initiated the work to genetically characterize all trees in the Swedish spruce breeding program managed by Skogforsk - to allow for the development of faster and more efficient spruce breeding for the benefit of Swedish forest owners. Several other activities of the program also aims for optimizing the interaction between Academia and practical tree breeding (at Skogforsk) 3. We have continued the work to get a deeper understanding of the somatic embryogenesis (SE) process in spruce, as SE of elite genotypes may be one of the paths towards mass-production of better plan material for the Swedish forests 4. We have continued the work using aspen/hybrid aspen as model system to understand important traits for trees like phenology, but also for example wood formation 84 (175)
Theme 3 1. At the forest faculty, we have a great data-base with data from the more than 1000 long term experiments that is maintained by the faculty. In theme 3 we have used data from existing long-term experiments to answer new questions. One example is analysis of long-term effects of regeneration intensity. Other examples are analysis of the effect of different management programs on production and economy and new tree species to be used in a changing climate. 2. As a way of climate mitigation, silviculture in fast growing broadleaved species is highly relevant. Fast growing broadleaves may be used for bioenergy production that can replace the use of fossil fuels. But fast growing broadleaves may also enhance biodiversity on a landscape scale and can be positive for recreational purposes. However, the two most promising tree species, hybrid aspen and poplars, have up until now mainly been planted on former agricultural land. If the use of these tree species is going to have a national impact, they must also be used on forestland. Therefore, we have put a lot of effort into investigating different ways to promote establishment and growth when hybrid aspen and poplars are planted on clear-cuts. We have established a nation-wide regeneration and production experiment where hybrid aspen and poplar are compared to Norway spruce and Scots pine. This experiment is long-term and will produce data on the effect of different tree species for many decades to come. We have also investigated various ways to treat the seedlings before planting. 3. Continuous cover forestry (CCF) have been debated intensively during the recent years and some claims that this silvicultural system may solve many problems, including biodiversity, carbon sequestration and forest economy. Even if this may not be true on all sites, continuous cover forestry may be a very interesting alternative on many locations and for many forest owners. We have investigated possibilities to convert today s homogeneous monocultures to a more heterogeneous stand structure that are more suitable for continuous cover forestry. We have also investigated regeneration and long-term productivity in CCF stands. In addition, we have established a series of long-term experiments that will produce a large quantity of interesting results in a near future but probably also for the next several decades. Theme 4 1. To establish metabolic engineering of plant oil in seeds and vegetative tissues, a number of activities were carried out including evaluation of GM-crambe with high erucic acid and wax esters, metabolic engineering of oil content and composition in Lepidium campestre, establishment of transformation protocol for barley and transformation of barley with candidate genes for insect resistance, metabolic engineering of plant oil in vegetative tissues, studies of oil accumulation in cambium cells of poplar and salix, studies on enzymes and genes involved in plant lipid biosynthesis, studies on molecular mechanisms of carbon flow in storage organs, studies of oil accumulation in Cyperus esculentus stem tubers, genetic engineering of starch quality and oil production in potato, and genetic engineering of sugar beets for altered carbon allocation, evaluation of AP1 as a target of photoperiodic signal in growth cessation, evaluation of ECH and YIP genes in control of cell elongation and cell wall biogenesis, studies on the role of Florigen activating complex in growth cessation response, expression of different wax ester genes in chloroplasts of Nicotiana benthamiana through genetic engineering, development of a novel selection system in plant transformation based on antisense oligodeoxynucleotide inhibition, transformation of rice with full-length and truncated Arabidopsis WRI1, transformation of Nicotiana benthamiana with a fusion wax ester gene of tpmafar::mhws, studies on genetic network controlling lipid accumulation in trees, studies on mechanisms underlying the control of bud dormancy. 2. To understand relationships between structures and functions of bio-based materials a number of major activities have been carried out including evaluation of impact of genotype and environment protein and starch qualities, evaluation of starch and protein qualities, structures and properties in potato, high amylose potato, wheat, barley, crambe etc, characterization of various additives as cross-linkers in biobased materials, 85 (175)
evaluation of options to use side-streams for biobased materials production, evaluation of options to produce fully biobased composites, and modelling of plant protein strucutures for predicition of qualities." Please describe the major results within the environment in 2013. (Question 3) "The major general results from the research environments are; - Increased number of young researchers within the research environment. - Increased opportunities for young researchers to develop into strong researchers through their existence in a strong research environment, with strong PIs and good opportunities to use new and up-to-date facilities and equipments as well as the network that the environment and the research school facilitate. - Increased network and opportunities for the PIs through the increased knowledge of each other and the facilities within the whole strong environment. - Increased number of publications in high ranked journals. - Increased number of international collaborations - Increased industrial network and collaboration. The major results of 2013 from the different themes are as follows; Theme 1 1. A new and original idea of how and why boreal forests are nitrogen limited. This study suggests that ectomycorrhizal fungi, previously regarded as facilitators of tree nitrogen uptake may in fact be the main drivers of nitrogen limitation in boreal forests. This result and the conceptual and mathematical models that were developed from it may have long-reaching effects on forest management. 2. To interpret measured 13C signals in terms of turnover and C flux rates of the ecosystem components a model has been developed, which will also enable the quantification of effects of nitrogen addition and season on ecosystem carbon and nitrogen cycling. The model is now being evaluated based on field data. 3. Lichens are components of the boreal forests (and many other ecosystems) that are particularly sensitive to nutrient availability. However, the mechanisms regulating their responses to environmental changes are not well understood. Based on the adaptive behavior of the individual lichen symbionts, i.e. the interaction between fungus and algae, a model has been developed to elucidate lichen responses to nitrogen and phosphorus availability. The model is currently under development and evaluation against experimental data. 4. A non-invasive method for monitoring of N fluxes in soil have previously been developed. Through further development, this method now allows for separate analysis of fluxes driven by diffusion and by mass flow. A new dataset that covers fertilized and non-fertilized forests and focuses on early-season soil N dynamics, largely corroborate the earlier finding that sol N fluxes in boreal forests are dominated by organic N. Further, the new data shows the dynamics of fertilizer N in soils of N limited and N replete forests. Theme 2 1. The publication of the Norway spruce genome sequence Theme 3 1. Description and models of the rate of ingrowth in continuous cover forestry 2. Long term effects of scarification intensity 3. Effects of soil pathogens on growth of lodgepole pine in Sweden 86 (175)
Theme 4 Studies on plant oil: Metabolic engineering of novel oilseed crops has been successfully established. Bottlenecks for ultra-high erucic acid production in GM-crambe seeds has been identified, providing new possibility to further increase erucic acid in this dedicated oil crop. Stable GM-crambe lines with wax esters in seeds have beene developed, but the inhibition of higher content of wax esters on seed germination needs to be improved and a solution to solve this problem has been identified. An efficient transformation protocol for a new and potential oilseed crop Lepidium campestre has been established and GM lepidium lines with the target traits/genes have been developed, suggesting a great potential of gene technology for fast track domestication of wild species. Specificities of plant LPCATs in their forward and reverse reactions have been first characterized with results questioning the present theory of mechanisms in plant membrane lipid acyl turnover. Storage oils and wax esters have been produced in leaves, showing the potential to utilize biomass in a more efficient way in the future. Novel candidate genes/enzymes in plant lipid biosynthesis and bud dormancy have been identified in plants, providing further possibilities for metabolic engineering of plant oils. Furthermore, a novel selection system in plant transformation based on antisense oligodeoxynucleotide inhibition has been developed. Studies on biobased materials: A model for protein content and structures in wheat has been developed and can be used for prediction in altered genotypes and environments. The model takes into account changes according to genotype and environment over the whole plant development period and predict quality for bread-making, pasta making as well as for biobased materials production; Modelling of proteins structures and relations to quality of biobased materials have been carried out and suitable protein structures for improved quality in materials are proposed. Further, the understanding of how the desired hexagonal close-packed structure is created is improved. The need and influence of various additives for creation of desirable structures due to their effects during depolymerisation, breaking of bonds, packaging of proteins and/or as cross-linkers or for creation of disulphide bonds indicate future options to tailor biobased materials and composites. Studies on starch: Enzyme steps necessary for starch accumulation in potato have been identified, providing possibility to further modify starch qualities or quantities. New method for starch quality analysis and new descriptors of amylopectin structure have been developed, which would facilitate future studies on starch quality and contribute to our understanding of starch physical properties. Studies on insect pheromone, bud dormancy and adventitious rooting: The feasibility of producing insect pheromones in plants has been proved, showing the potential of producing insect resistant plants using gene technology. Some molecular mechanisms of bud dormancy have been identified, providing theoretical bases for controlling plant growth and cessation in forest. An efficient rooting protocol of adventitious rooting (AR) from stems has been developed with the origins and molecular mechanisms of AR induction were identified and characterized, which would contribute to our understanding of AR-formation for vegetative propagation. Modelling wheat protein content and structures. A model for protein content and structures in wheat has been developed and can be used for prediction in altered genotypes and environments. The model takes into account changes according to genotype and environment over the whole plant development period and predicts quality for bread-making, pasta making as well as for biobased materials production. Modelling protein structures in biobased materials. Modelling of proteins structures and relations to quality of biobased materials have been carried out and suitable protein structures for improved quality in materials are proposed. Further, the understanding of how the desired hexagonal close-packed structure is created is improved. The need and influence of various additives for creation of desirable structures due to their effects during depolymerisation, breaking of bonds, packaging of proteins and/or as cross-linkers or for creation of disulphide bonds indicate future options to tailor biobased materials and composites.." 87 (175)
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9. Strategiskt forskningsområde: IT och mobil kommunikation, inklusive framtida lösningar för kommunikation och ledningssystem Huvudansvarig myndighet: Samrådande myndighet: Vinnova Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 45 55 80 80 80 Avsättning till infrastruktur 9 11 16 16 16 Budget efter avsättning 36 44 64 64 64 9.1 ICT The Next Generation Huvudsökande: Kungliga Tekniska Högskolan 90% Medsökande: Stockholms universitet 10% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 33 300 000 Personell 15 872 000 Co funding from main applicant higher education institution 90 880 000 Running costs 7 673 000 Co-funding from-co-applicant higher education institution 3 500 000 High cost Equipment 29 000 Funding from collaborating research institutes 0 Infrastructure running costs 1 528 000 Funding from other collaborators 0 Other costs 6 847 000 Other external funding 205 531 000 Totalt: 31 949 000 Totalt: 333 211 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. Source Sum of kkr EU-framework programmes 60 487,29 Other 1 107,54 other international funding 563,63 private companies 17 170,96 private non-profit organisations 2 633,15 funding from public agencies 84 242,62 public research foundations 39 326,18 Grand Total 205 531,39 89 (175)
Please state the main priorities within the environment in 2013. (Question Q1) "The SRA ICT TNG environment had as main priorities during 2013 to continue the recruitment of young researchers ( rising stars ), and also to improve the collaboration between Universities and Institutes by creating models for mobility of researchers between these institutions. As in previous years (2011-2012), attention has been put on evaluating the renewal effect of the so-called Focus Projects. The purpose of these projects has been to create new constellations of research groups and industry partners, based on the pattern established in KTH s successful VINNOVA and Linnaeus Excellence Centres, in order to create a critical mass in a few number of strong research and innovation environments. The consortium has targeted four key areas, namely The human in the loop complex interaction without tears (or fears) Affordable and sustainable ICT infrastructure reducing cost and energy Internet of things wireless networks of unprecedented reliability Mastering complexity managing dynamically evolving ICT systems, These key areas address challenges in usability, scalability, and sustainability that we believe are of paramount importance for the continued development of Sweden as a leading ICT nation." Please describe the major activities within the environment in 2013. (Question Q2) "Three types of activities have been carried out within the SRA ICT TNG thematic areas: Within the faculty renewal activity, four new talented researchers ( rising stars ) have been recruited as faculty members. That makes in total 15 new faculty members recruited within the TNG program. Most of these positions had international applicants of excellent profile, ensuring the highest quality of the employed researchers. During 2013 a SRA TNG accelerated career workshop was organized to promote reflections on career development for the recruited TNG faculty. The discussion in the workshop was lead by a distinguished group of research leaders, including the head of Eriksson research, a former chair of the Nobel Prize committee in Medicine, the head of VINNOVA and an IEEE Honor award recipient. Within the activity on developing the TNG consortium, 5 focus projects were executed within the thematic areas: e-participation, Situated Audio Visual Interaction with Robots, Reliable Industrial Communications, Energy Efficient Wireless Infrastructure and Complex Systems Engineering. A new sabbatical and postdoc program was established with an emphasis on institutes-university cross collaborations." Please describe the major results within the environment in 2013. (Question Q3) Within the TNG strategic research there have been several significant results. Some examples include: - Recent growth in cellular networks and Internet of Things (IoT) has increased the demand of network capacity and resource consumption. Strategic research at TNG has shown that new engineering techniques have the great potential to enable a completely new type of networked information systems, exhibiting unprecedented efficiency in the usage of all resources, especially energy. Further research is focused on developing new networking system-level strategies to fully utilize the broadcast nature of wireless communication and 90 (175)
adaptation techniques to meet monitoring and control application demands with the least environmental impact. - In the area of wireless sensor networks and internet of things, researchers at TNG have established new fundamental research results with networking protocols, distributed information processing, and controls. The availability of SRA ICT TNG funds has allowed establishing new research groups and collaborations with researchers of other universities and research centers within SRA TNG. - During 2013, SRA has made it possible to continue research efforts on conversational and multimodal interfaces, including a new research infrastructure for social human-robot interaction. - Thanks to funding from TNG, research activities have been intensified and broadened in areas like network deployment, indoor systems and small cells, energy efficient systems, and spectrum access. - New activities have also started in the area of machine-to-machine (M2M) communication and Internet of things (IoT), covering technical, techno-economic and business aspects. The activities have led to approval of two big EIT ICT Lab projects for 2014, in total 14 MSEK and for COS 2MSEK, to be developed in conjunction with Ericsson, Nokia, Orange, Siemens and Aalto University. 91 (175)
9.2 elliit the Linköping Lund Initiative on IT and Mobile Coummunication Huvudsökande: Linköpings universitet 45 % Medsökande: Lunds universitet 45%, Blekinge Tekniska Högskola 5%, Högskolan i Halmstad 5% c. Income of the strategic research environment 2011 (all income, Question C3a) d. Costs of the strategic research environment 2011 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 30 700 000 Personell 19 515 569 7 183 800 Running costs 2 747 774 Co-funding from-co-applicant higher education institution 11 996 205 High cost Equipment 117 652 Funding from collaborating research institutes 0 Infrastructure running costs 359 540 Funding from other collaborators 0 Other costs 7 959 465 Other external funding 32 196 131 Totalt: 30 700 000 Totalt: 82 076 136 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Funding from public agencies 10 796 597 Public research foundations 15 852 909 EU-framework programmes 2 321 118 Other international funding 370 487 Private non-profit organisations 641 761 Private companies 2 213 258 Please state the main priorities within the environment in 2013. (Question Q1) "The main priorities during 2013 have been on the continuation of the strategic recruitment in the IT area of researchers from the international arena, increasing the interaction with the industrial stake holders and to continue to increase the evolving fruitful co-operation among the involved groups. Fundamental research about ICT systems and applications with the aim to improve performance, resource-efficiency, scalability, autonomy, and time to market have been achieved through selected projects. The research priorities during 2013 cover a relatively broad technical area including: new means of wireless communication, supporting increasing demands on data rate, reliability and cost efficiency as well as new applications such as traffic safety; programmable parallel hardware platforms ; optimization of heterogeneous networks energy efficiency of wireless systems; initiation of new collaboration with Swedish ICT industry within Electronics; Foundations and tool support for stream programming: formal models, hardware synthesis and 92 (175)
software code generation, profiling and analysis methods and tools; Control and scheduling co-design methods: worst-case stability aware optimization of computational resources, server-based scheduling, and response-time driven control design; Extending resource management techniques developed for embedded multicore applications to server-based cloud applications; lean software testing, tools and languages for highlevel physical modeling and optimization languages, and secure web technologies; Visual Surround Sensing for vehicles; Visual Object Tracking in real-time on embedded platforms; Creating new algorithms for natural language processing and scene analysis of images; novel in-door positioning techniques; 3D scene modelling from images; development of the theoretical foundations of algorithms for computing schedules of unmanned vehicles preforming collaborative search; develop efficient methods for automated task assignment and sequencing during missions conducted by autonomous unmanned vehicles; Theoretical development and applied use of collaborative UAV systems; improving realistic rendering through new algorithms, for both ray tracing and rastering, as well as cartoon rendering; combined sensor fusion and learning; Iterative Learning; Optimal maneuvers; robust stability analysis mechanisms for large-scale systems that are weakly connected." Please describe the major activities within the environment in 2013. (Question Q2) "The strategic recruitment of researchers has continued. The series of Technology Visits at the members of the ELLIIT Industrial Board have been continued, with the aim to increase the interaction with the industrial partners, verify the relevance of the research topics for the industry and to identify possible new opportunities for collaborations. A main priority for the ELLIIT projects is that at least two of the member sites must be involved in each project. One of the most important events for strengthening the collaborations is the yearly workshop which during the four events so far each gathered about 150 participants from the environment. Apart from new collaboration in research projects and co-publications, one of the most important effects is the increase in externally joint grants and projects involving PIs from several ELLIIT partners. In the research areas, the main activities have been focused on: continued development of hardware-friendly multiuser pre-coders, new propagation measurements and analysis of the effect of hardware impairments in massive MIMO systems; increasing reliability and predictability in major vehicular ad-hoc network; optimization of resource allocation, routing, and deployment in the realm of future cellular, wireless mesh, and heterogeneous networks; electronics design challenges, with special focus on energy-efficient wireless transceiver front-ends and data converters for future mobile broadband communications as well as for lowpower sensors; methods for mapping and code generation for custom many-core architectures; reliabilityenergy trade-offs in fault-tolerant distributed real-time systems. improving the language coverage and quality of hardware synthesis, add compile-time power optimizations, improve scalability and precision of analysis tools in Xronos and Turnus stream programming tools; Controlled experiments to evaluate concrete improvements of testing processes; Development of new debugging and requirement tools, and improved parallel execution for Modelica; Development of new tool generation techniques for hybrid languages; Activities related to malware analysis evasion techniques, trusted computing in high availability environments and streaming services; build the AMUSE dataset, which contains more than one terabyte of real-time recordings from the LiU instrumented vehicle, including programming API and a real-time streaming option; development of several algorithms for visual object tracking, suitable for real-time processing on embedded platforms such as the Linkquads; Development of scientific foundations, algorithms and prototype implementations of collaborative system architectures for UAVs; development of a Real-Time Ray Tracing system running on GPUs using the CUDA data parallel programming language; development of a novel technique that improves the performance of the well-known Light Propagation Volumes using Octree; experimental evaluation of ILC for machining applications; developed distributed algorithms for solving feasibility problems that have superior convergence properties and allow detection of feasibility and infeasibility in a distributed way. Other activities includes initiation of new or increased research collaboration with Swedish companies such as Ericsson, Saab, and Silex Microsystems; improvement of contents and quality of undergraduate courses and 93 (175)
preparation of new PhD courses. The new Mobile and Pervasive Computing Institute (MAPCI) has been created at Lund University with funding from Sony Mobile Communication, Lund University, and the local region and with ELLIIT professor Björn Landfeldt as the scientific director." Please describe the major results within the environment in 2013. (Question Q3) "The mid-term evaluation of the environment resulted in valuable feedback with relevant recommendations. An action plan based on the feedback was made and fully implemented during 2012 and affected the continued work plan for 2013. In order to increase the interaction with the industrial board, the Co-Director has been assigned to be the main responsible node for general ELLIIT communication, including distribution of a quarterly newsletter. Based on a project evaluation and second call for projects, the project portfolio has been vitalized with completion or extension of some projects and start of new projects. The project portfolio was evaluated by the industrial board and adjusted according to suggestions. The fourth yearly workshop gathered about 150 participants from the environment. Some highlights from the research activities within ELLIIT areas are: a number of fundamental results have been established in the area of massive MIMO including new techniques for the analysis of the effects of hardware imperfections, implementation of fundamental processing blocks, analysis of synchronization, improved understanding of real channels, and the extension of the massive MIMO concept to distributed relaying networks; The ELLIIT activities in this area has also led to a new EU project, MAMMOET, which received the highest possible grade in the evaluation process; A four year project funded by VINNOVA and the industry partners with a total budget of 71.6 MSEK has been started; Efficient 60GHz CMOS radio transceiver frontends, such as power amplifiers, signal generators, antenna tuners as well as novel wideband flexible RF DACs with sampling rates up to 10GS/s have been developed for state-of-the-art for future multi-gigabit/s high data-rate mobile broadband communications; new digital schemes for correction of channel mismatch errors in high-speed time-interleaved ADCs, and efficient reconfigurable schemes for recovery of sub-nyquist sampled sparse multi-band signals; development of a technique for priority assignment and sensitivity analysis for control applications considering stability as the main requirement; development of an integrated approach for designing bandwidth-efficient controllers with server-based resource sharing; design of and evaluation of a novel hybrid testing process; new integrated debugger for equation-based languages (Modelica), handling execution errors during equation solving; The AMUSE dataset has been presented at a CVPR workshop on evaluation datasets and as a showcase in a 360 degree movie theater during the CAIP conference in York; One of the developed tracking algorithms achieved the third rank in a worldwide challenge on visual object tracking in context of the International Conference on Computer Vision in Sydney; The open robot control architecture (Orca/ExtCtrl) has been further developed in close collaboration with ABB Robotics and constitute the major research platform for the robot experiments conducted. The platform is now also used in a number of academic research labs and invites for international collaboration; an asymmetric relay auto-tuner for PID controllers has been developed.. Furthermore, the Inviwo visual computing research platform has been developed and released. Inviwo is a modular software system, which enables algorithm prototyping on different levels of abstraction, while granting full exploitation of the capabilities of the underlying hardware. The technology is also the basis for Vistinct, a spinoff created from within the ELLIIT environment." 94 (175)
10. Strategiskt forskningsomtråde: Klimatmodeller Huvudansvarig myndighet: Samrådande myndighet: Formas Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 10 20 30 30 30 Avsättning till infrastruktur 1 2 3 3 3 Budget efter avsättning 9 18 27 27 27 10.1 ModElling the Regional and Global Eart system MERGE Huvudsökande: Lunds universitet 65% Medsökande: Göteborgs universitet 20%, Högskolan i Kalmar/Lunds universitet 5%, Chalmers TekniskaHögskola 5%, Kungliga Tekniska Högskolan 5% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 8 750 000 Personell 5 064 973 Co funding from main applicant higher education institution 9 410 759 Running costs 942 924 Co-funding from-co-applicant higher education institution 5 343 686 High cost Equipment 270 638 Funding from collaborating research institutes 0 Infrastructure running costs 48 000 Funding from other collaborators 0 Other costs 2 262 695 Other external funding 44 410 333 Totalt: 8 589 230 Totalt: 67 914 778 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Most of the "other external funding" consists of relevant research grants at Lund University and Gothenburg University. The main funding sources of these amounts are: * Lund University: The Swedish Research Council (49%), the Swedish Research Council Formas (27%), EU (7%), others (17%). * Gothenburg University: The Swedish Research Council (31%), the Swedish Research Council Formas (27%), EU (3%), the Swedish Energy Agency (27%), others (12%). 95 (175)
Please state the main priorities within the environment in 2013. (Question Q1) "ModElling the Regional and Global Earth system (MERGE) is a research programme within the Strategic research Area (SRA) Climate Models. The MERGE vision is to establish and develop a major multidisciplinary climate/earth System modelling node based on world leading research and research education on climate/terrestrial biosphere interactions. MERGE brings together key Swedish competence from five universities and the Rossby Centre of the Swedish Meteorological and Hydrological Institute (SMHI). The development of the Strategic Research Area as a whole, including all collaborating parties, continued to be an overarching priority. In 2013, MERGE involved 126 persons, including senior scientists, young scientists and other contributing staff. MERGE is a Strategic Research Area (SRA) on climate modelling which, in particular, focuses on vegetation and terrestrial ecosystems. Vegetation, land use, ecosystems, the carbon and nutrient cycles, tropospheric ozone, biogenic aerosols, and soot are important in the climate system as forcing and involving various processes and need to be incorporated into advanced climate models, for improved scenarios. Under global warming, changes in these components furthermore give rise to feedback effects that further escalate or counteract the direct effects of anthropogenic emissions. In 2013, the main priorities were: (i) Finalise the first version of the advanced global Earth System/climate model EC-Earth with coupled vegetation, in preparation for the next major international climate modelling experiment, the so-called CMIP6. (ii) Application of climate models in past climate research, climate process investigations and future scenario studies on regional scale (100+ simulations), and also globally, in collaboration with international coordinated experiments. (iii) Further develop the stakeholder interaction and communication of research on climate models to stakeholders and the public at large. A major outreach thrust was made in conjunction with the first part of the Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) in September 2013." Please describe the major activities within the environment in 2013. (Question Q2) During 2013 MERGE consolidated many results from 2010-2012 into new model versions and scientific applications. The stakeholder contacts were further strengthened. RESEARCH: During 2013, efforts focused not least on the Earth System/climate model EC-Earth with coupled vegetation, in anticipation of the next major international climate modelling experiment, the so-called CMIP6, which will not least involve Earth System models. The year also featured scenario studies especially on regional scale (100+ simulations) and globally studies, in collaboration with international coordinated experiments, as well as research questions relating to the role of nitrogen in the global climate/earth system, feedback and change. Further work was done on aerosol particle representations and description for use in process studies, air quality models and subsequently within climate models. RESEARCH EDUCATION: The cross-disciplinary graduate research school (ClimBEco) which is a joint venture with the SRA BECC (Biodiversity and Ecosystem Services in a Changing Climate), and provides advanced research education in climate, biodiversity and ecosystem services science enrolled 22 new students and a second round of the mentoring programme for PhD students was initiated. STAKEHOLDER INTERACTION: The stakeholder group with which MERGE conducts active interaction (members from the Swedish Forest Agency, AirClim, the Swedish Board of Agriculture, the County Administrative Board of Skåne, the Federation of Swedish Farmers, the Swedish National Heritage Board, Sveaskog and Högestad & Christinehof Förvaltnings AB) was joined also by the Swedish Environmental Protection Agency. The interaction 96 (175)
during 2013 led to identification of pertinent knowledge needs and instruments (event, syntheses, briefs) how to address these. Please describe the major results within the environment in 2013. (Question Q3) During 2013, new results covered continued global and regional climate model improvements on the representation of coupled interactions between vegetation and land cover, as well as on the representation of nitrogen interacting with the carbon cycle, atmospheric composition, and the overall climate system with studies on climate feedback effects. These developments, which are result from collaborative activities and in some cases intensively worked on for many years, were consolidated during 2013 in new model versions and applications in addressing specific research questions, with international significance. The latest efforts target such climate model development priorities that enable the Swedish climate modelling community to have a strong presence in the upcoming international activities (CMIP6) and in particular to address Earth System (climate) feedback, the stability of ecosystems and carbon sinks facing continued global warming. Specific capacities are being developed to address such key regions as the Arctic and Africa. Among specific MAJOR RESULTS are: * The first version of the advanced global Earth System/climate model EC-Earth with coupled vegetation was finalised, which aims at a significant contribution to the next major international climate modelling experiment, the so-called CMIP6. * Climate models which have been under development were applied in scenario studies especially on regional scale (100+ simulations) and globally studies, in collaboration with international coordinated experiments. * Research on climate feedback involving vegetation, carbon cycle, and nitrogen cycle was pursued with new results and insights. By accounting for nitrogen-carbon interactions under climate change, global terrestrial carbon sinks appear more stable than most previous simulations have suggested. * The study of past land use-climate interactions in Europe scale; first known sensitivity experiments related to land-use at this scale, shows that the increase in deforestation between 6000 and 200 years before present had larger effects on climate than what has been expected. * Strong outreach activities, not least in conjunction with the IPCC AR5. 97 (175)
10.2 Modelling initiative of the Bert Bolin Centre for Climate Change Huvudsökande: Stockholms universitet 90% Medsökande: Kungliga Tekniska Högskolan 10% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 18 300 000 Personell 9 257 038 45 700 000 Running costs 5 189 737 Co-funding from-co-applicant higher education institution 225 000 High cost Equipment 0 Funding from collaborating research institutes 14 000 000 Infrastructure running costs 0 Funding from other collaborators 0 Other costs 0 Other external funding 68 100 000 Totalt: 14 446 775 Totalt: 146 325 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. The post "Other external funding" contain substantial contributions from other SRA grants (SeRC, SU-EkoKlim and SU-BEAM), VR, Formas, EU FP7, Office of Naval Research, Swedish Space Board, Swedish Geological Survey, SIDA, SSF and SKB. Please state the main priorities within the environment in 2013. (Question Q1) During 2013, the main priorities within the environment have been: - To highlight the uniqueness and strength of the Bolin Centre at the interface of climate observation and climate modelling. - To further establish the Bolin Centre as a scientific meeting place for our wide spectrum of disciplines. - To continue building a long term future for the Bolin Centre by firmly grounding the Centre as a part of its host Departments at Stockholm University, KTH and SMHI. - To complete the recruitment of scientists with SRA funded tenure positions. - To recruit PhD-students and post-doctoral Bolin fellows. - To fully involve the SRA recruited staff in the activities and leadership of the Bolin Centre. - To recruit scientific programmers and ensure continued access to enough high-performance computing resources. - To improve communication within the Bolin Centre and with the society about climate science and to create a national and international identity for the Bolin Centre. 98 (175)
Please describe the major activities within the environment in 2013. (Question Q2) To achieve the priorities we have taken the following actions, several of which stem from the Bolin Centre now operating under new leadership and with a new structure: - Merging the strategic research area (SRA) with the original Bolin Centre, both structurally and financially. - Implementing a new leadership structure for the Bolin Centre: The centre is from 1 January 2013 governed by a Board defined by the Faculty of Science with the Dean for Earth and Environmental Sciences as its chair. The Board members are the Heads of the four participating departments at SU, representatives from the partners at KTH and SMHI and one member from the Swedish Environmental Protection Agency. - Implementing a new organizational structure for research and internal communication: The research is from 1 January 2013 reorganized into six Research Areas that have been chosen to span at least two disciplines and two departments. Co-leaders for each Research Area have been chosen from the senior scientists recruited with the SRA paired with senior scientists who are engaged in observational and/or process-related climate science. - Helping to secure extra funding (20 million SEK) from VR Infrastructure to the SNIC budget for computational resources for climate modelling. This was made possible based on our 2012 application to VR Infrastructure. - Recruited and organized scientific programmers to ensure good technical support for the scientific modelling staff. - Recruited a junior lecturer, a number of post-docs and PhD students. - Recruited a full time communication specialist and invested heavily in profiling, communication and outreach activities. These include representation at major conferences, internal communication events and outreach activities for schools and society. Please describe the major results within the environment in 2013. (Question Q3) The most important result of 2013 is that the Bert Bolin Centre is now a close to gender-balanced team of over 200 highly productive and enthusiastic scientists, many of whom are junior. We have a sustainable research environment that for years to come will continue to produce excellent science and education in the broad area of climate science with the potential to help solving some of the highly important questions regarding climate change that society faces today. In 2013, Bolin Centre scientists have published almost 230 scientific papers in peer-reviewed journals. Of these, 7 were published in Nature or Science journals. A major event for Climate Science during 2013 was the publication of the fifth IPCC assessment report of working group 1; The Physical Basis. Bolin Centre scientists took part as scientific advisors in the final negotiations of the Summary for Policymakers that were held in Stockholm and the report was dedicated to Bert Bolin during an event co-organized by IPCC, KAW and the Bolin Centre. More than 70 references in the IPCC working group 1 report are made to papers authored or co-authored by Bolin Centre scientists. The most important climate modelling support to the recent IPCC assessment report is the Coupled Model Intercomparison Project phase 5 (CMIP5) where the Bolin Centre contributed with simulations. Focus during 2013 has been on analysing the results of our own CMIP5 simulations with EC-Earth as well as studies using the whole suit of CMIP5 simulations. The development of the next version of EC-Earth, aiming for the next CMIP for which planning is ongoing, is led 99 (175)
by Bolin Centre scientists at the Rossby Centre. It is progressing as planned and further development, analysis and preparatory simulations for CMIP6 are ongoing. In terms of research training in climate science, 11 PhD students successfully defended their PhD theses in 2013 and two defended their licentiate theses. 100 (175)
11. Strategiskt forskningsområde: Materialvetenskap, inklusive funktionella material Huvudansvarig myndighet: Samrådande myndighet: Vinnova Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget (MSEK) 25 35 65 65 65 Avsättning till infrastruktur 5 7 13 13 13 Budget efter avsättning 20 28 52 52 52 11.1 Strategic Initiative Materials Science Huvudsökande: Chalmers Tekniska Högskola 88% Medsökande: Göteborgs universitet 12% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 24 139 000 Personell 12 994 000 Co funding from main applicant higher education institution 12 070 000 Running costs 5 335 000 Co-funding from-co-applicant higher education institution 1 440 000 High cost Equipment 817 000 Funding from collaborating research institutes 0 Infrastructure running costs 194 000 Funding from other collaborators 0 Other costs 4 683 000 Other external funding 0 Totalt: 24 023 000 Totalt: 37 649 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Government strategic research fundings include co-fundings to co-applicant. Co-foundings from co-applicant within the material science area is Gothenburg University with 1 440 000 kr. Chalmers has chosen not to report the amount of external funding above because of the difficulty to produce figures that accurately reflect the funding situation in the strategic research area (SRA). This has several reasons, for example: (i) a fairly large portion of the researchers are involved in more than one AoA and their external grants might partly or entirely be used for projects in other areas, making it difficult to determine to 101 (175)
what extent the external funding should be attributed to one or the other area, (ii) some researchers are involved in research within the area, but not directly associated with the AoA, and therefore do not report their results or external funding here. Also, (iii) external funding received by researchers involved in the area at our partner universities is difficult to determine and to include in a relevant way. During 2013, Chalmers has investigated and considered several different models for reporting external funding to these environments, both by internal analysis and by conferring with some of the other involved Swedish universities. We have recently decided on a model for reporting external funding in a satisfactory and authentic way and will use this for reporting for the entire period of 2010-2013 during the self-evaluation in spring of 2014. Please state the main priorities within the environment in 2013. (Question Q1) "The main priorities within the strategic research environment of materials science at Chalmers and the University of Gothenburg for 2013 have been: - Further development of our research by stimulating excellence, interdisciplinary activities and scientific exchange, fostering new ideas and improving the conditions for young researches. A particular effort has been put on developing the role of our excellence profiles: to coordinate new research lines involving several different groups and departments and to attract researchers externally. - Community building, including the extended community with partners in industry and research institutes, and outreach to establish and further develop our communication channels. During 2013, we have further strengthened our interaction with our three international partner universities and put particular effort on establishing more formal connections with universities in Asia. - Establishment of common research infrastructures, meeting the needs of our researchers in key areas. During 2013 our particular focus was on developing a central infrastructure for materials characterization. - Development of the new area of Sports Technology. During 2013 we also started looking into a future organisation and strategy for this growing research field. - Integration of education with the research environment to further develop the interaction with graduate schools, master programs, undergraduate education and their students at the different departments involved in the strategic environment. A particular goal has been to increase the involvement of undergraduate students in our research." Please describe the major activities within the environment in 2013. (Question Q2) "Development of research: - Continued efforts to support young researchers. Our new assistant professor Dr. Sheng Guo, recruited from City University of Hong Kong, started this year. Together with the department of Materials and Manufacturing Technology we have offered a start package in order for Dr Guo to rapidly gain momentum. Dr Guo has already recruited a PhD student and started to acquire the necessary lab equipment. - Development of our excellence profiles has been supported through dedicated grants to each profile (Health, Energy, Sustainable materials, Theory and modelling, Experimental methods). The aim is to stimulate collaboration between complementary competences within the strategic environment, towards challengedriven topics or the development of methods to support these. The grants have mainly been devoted to interdisciplinary projects and external recruitments, thereby strengthening the research in materials science. - Developing research through our strong excellence centres. A particular focus this year has been towards sustainable and soft materials. The establishment of Competence Centre for Recycling was one major activity and the renewed funding of the Wallenberg Wood Science Centre WWSC (shared with KTH) was another important milestone. The strong support by the Wallenberg foundation to WWSC underlines the strategic aspect of this area and the strength of the research environments involved. 102 (175)
- Continued focused effort on Soft Microscopy, a project with strong involvement by the research institute SIK, and on the methods development project Theory and Modelling. - Supporting exchange visits and establishing formal agreements with leading universities (Stanford, UC-Santa Barbara and ETH- rich). Workshops have been organized with Stanford (at Chalmers), UCSB (in Santa Barbara), and with ETC-Z (at Chalmers). In addition to the workshops we have supported research visits by both faculty and PhD-students. Our contact person at UCSB, Brad Chmelka, was appointed honorary doctor at Chalmers in May, and both professor Chmelka and our contact person at Stanford, professor Bob Sinclair, participated in a focus seminar on research infrastructure politics in Gothenburg in December. - Consolidating the work in the new area of Sports Technology. Together with sporting federations, clubs, sports industry and the interested public we have arranged a number of topical workshops and also pursued shorter research projects. Examples are the application of smart textiles to horses (see Q3) and motion capture of the start in swimming (http://www.youtube.com/watch?v=qtxz6qoccim). The work has got the attention both regionally and nationally, and been additionally funded by Västra Götalandsregionen (VGR). - Development of research in the graphene area. Chalmers leads the Graphene Flagship, one of two Flagship projects funded by the European union. As a result of this we have focused on further developing and coordinating our research in this area. One such initiative is the establishment of the Graphene centre at Chalmers. (www.chalmers.se/en/centres/graphene/pages/default.aspx) Community building and outreach: - Development of the web-platform, newsletter and information meetings for researchers as well as students (regarding master programs and career opportunities). - During 2013, our excellence profiles have taken additional responsibility in organizing topical workshops, with the aim to gather scientists from various disciplines in order to develop new ideas, e.g. within perception of materials, new experimental methods etc. We have also supported other topical workshops, such as nanomaterials for energy applications. - Supporting organization of international and national conferences. - Organizing the yearly Materials for Tomorrow conference. This year the first day focused on the public audience, with popular presentations by our PhD students and an exhibition with new materials, implants, sailing boats and even a horse. Infrastructure: - During 2013, we have continued to take an active role in the realization of a Materials for Health Laboratory and a central facility for materials characterization. We have participated in a strategic group for the development of the materials characterization laboratory as well as in Chalmers central infrastructure group, headed by the vice president, with the aim to launch an open Chalmers research infrastructure, simply and efficiently meeting the needs of materials scientists in Gothenburg. We are also taking an active role in the development of MaxIV in Lund. Integration of education: - We have continued the summer internship exchange program with UCSB. Three Chalmers students worked as UCSB for ten weeks, while two students from UCSB worked at Chalmers. There is a great interest for the program, both at Chalmers and at UCSB. - The internal internship program (amanuens) started last year has been further developed. During 2013, 10 students have been given the opportunity to work in our strategic research environment. The students participate in a research project while being employed 10% in a research group during one semester. - Masters students were invited to and participated in the annual workshop Materials for Tomorrow." 103 (175)
Please describe the major results within the environment in 2013. (Question Q3) "The progress in the strategic environment is excellent. There are a number of important results from our work during 2013 in research, in outreach and networking, in utilization of the results, and in education. In this section we briefly summarize these results, as they are reported in detail in other parts of the questionnaire. Research The most important research results are detailed in section D1a. Here we just provide a condensed overview: - More than 270 papers have been published by the researchers from the strategic environment. In general these are published in journals with high impact factors. More than 100 Masters thesis projects have also been performed, in many cases in collaboration with industry, and 38 Licentiate and PhD students presented their theses in 2013. - We obtained a number of large strategic grants during 2013: for the development of research infrastructure (KAW), for the development of next generation batteries (Energimyndigheten), and for the development of foamed materials for packaging and absorbents based on forestry by-products (FORMAS). In the coming years, these grants allow us to even further develop our excellence profiles in Materials for energy applications, Sustainable materials and Experimental methods, and consolidate our strengths in these areas. - The excellence of our young researchers was recognized by for instance ERC (starting grant to Kasper Moth- Poulsen), KAW (Academy Fellow grant to Martin Andersson), and the award from the HM King Carl XVI Gustaf's foundation for science, technology and the environment (Kasper Moth-Poulsen and Anna Martinelli). Outreach and networking- A large number of workshops and meetings have been arranged with participation from industry and research institutes. Our yearly conference Materials for Tomorrow attracted more than 200 participants; the theme this year was Sustainable Materials and Materials for Health with invited speakers from all over the world. We also organised a focused conference on Frontiers of Silica Research together with AkzoNobel, in order to further develop our platforms for meetings between industrial and academic researchers. - Joint workshops have been organized with our partner universities Stanford (meeting at Chalmers), UC-Santa Barbara (in Santa Barbara), and ETH-Zürich (at Chalmers). We have also arranged exchange of staff and students with these universities during 2013, in addition to approximately 60 longer visits to/from other universities around the globe. - We have continued our initiative on Sports Technology (www.sportteknologi.se) with workshops on athletics (arranged together with the national federation for athletics) and cross-country skiing. The latter event attracted 300 hundred participants. The first scientific result of the project also appeared as a result of a collaboration between our scientist and veterinarians in Australia, an article on the application of smart textiles to measure the ECG of horses in a friendly way (Journal of Veterinary Behavior 9, 34 (2014)). - Results from the strategic environment are getting attention outside of the scientific community. Two examples are an article about our Sports & Technology projects in the horse magazine Equipage, and a halfpage article in Råd&Rön about Christian M ller s research on finger prints for label clothes. Utilization of results and knowledge: - The utilization of research results and knowledge is perhaps best shown in the large number of collaborations with the industry, research institutes and public organizations. Currently, there are active collaborations with around 90 organizations, excluding academic collaborations (see question B3). - The utilization of research results is also shown by the 3 new companies started this year as spin-offs from the strategic environment and the 10 new patents/patent applications. - Graduate students are among the most important outcomes from our environment. During 2013, 38 Licentiate and PhD students and more than 100 masters students presented their theses in the strategic environment. Many of the theses, on all three levels, were performed in collaboration with industrial partners and research institutes." 104 (175)
11.2 International Interdisciplinary Materials Science Laboratory for Advanced Functional Materials Huvudsökande: Linköpings universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 28 000 000 Personell 10 258 667 0 Running costs 5 019 085 Co-funding from-co-applicant higher education institution 0 High cost Equipment 855 150 Funding from collaborating research institutes 0 Infrastructure running costs 229 987 Funding from other collaborators 0 Other costs 5 175 230 Other external funding 0 Totalt: 21 538 119 Totalt: 28 000 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. No other external funding Please state the main priorities within the environment in 2013. (Question Q1) "1) With all the strategic recruitments and most strategic research instrument procurements now installed (as laid out in the proposal) we now focusing on expanding synergy for multidisciplinary impact. 2) To continue expanding the number of researchers engaged in the environment by integrating laterally between research groups at the university. 3) To disseminate results in a growing number of publications. 4) To expand collaboration with industry, including maximizing impact." Please describe the major activities within the environment in 2013. (Question Q2) Synthesis of novel advanced functional materials (electronic, engineering, polymeric) by physical vapor deposition, chemical vapor deposition, wet chemical, spin coating and printing, et.c., including development of new such process and their monitoring/ control. We invest in our materials science and nanotechnology laboratories for state-of-the-art characterization, and building of expertise catering to the whole AFM environment. Consolidating our high dissemination rate and enhancing PhD graduation. 105 (175)
Please describe the major results within the environment in 2013. (Question Q3) Major AFM environment achievements: The Graduate School AGORA MATERIAE in Materials Science is now well established and musters 45 PhD students and organizes courses, seminars, visits and conferences. The Advanced Functional Materials conference has been developed and planned for during 2013. The AFM conference will be held on the 20-21 of August 2014 at Vildmarkshotellet, Kolmården. The AFM industry panel was gathered in Nov. 2013. One outcome of this event is that the AFM steering committee will develop a vision plan for the material science activity at LiU beyond 2014. A next meeting to be held at Volvo is planned to take place during the spring of 2014. AFM has established or further strengthened joint collaboration with industry (ST Microelectronics, Siemens, Sandvik,), spin out companies (ThinFilm AB, Impact Coatings AB, Norstel AB, DP Patterning AB, Invisense AB), institutes (Max Planck Institute, Los Alamos National Lab, CNRS). Major career development and recruitments: Xavier Crispin, Johanna Rosén and Björn Alling are being promoted to professor or lecturer at LiU. Prof. Martijn Kemmerink was recruited to LiU within the material science area and organic electronics. Graduation of AFM PhDs: Several PhDs has graduated within AFM and was employed by industry and startups, exemplified by X. Wang (ThinFilm, Linköping), J. Kawahara (Lintec, Tokyo), L. Johnson (Sandvik, Stockholm), R. Eriksson (Siemens, Berlin), A. Eriksson and A. Khatibi (Oerlikon Balzers, Lichtenstein). Several PhDs has graduated within AFM and has been employed as young scientists (postdoctoral fellows) at different universities and institutes, exemplified by O. Bubnova (Cambridge, UK), O. Hellman (VR-postdoc, Caltech, USA), S. Schmidt (LiU), K. Tybrandt (VR-postdoc, ETH, Zürich, Switzerland), J. Palisaitis (Forschungszentrum Jülich, Germany). Major scientific and technology results: A collaboration between several AFM scientists lead to the discovery that conjugated polymers exhibit semimetallic properties [Nature Materials, on-line publication 2013]. In collaboration between Univ. Regensburg, Chalmers and AFM-LiU an experimental demonstration of magnetic quantum ratchet effect in graphene has been achieved [Nature Nanotechnology]. The etching module for graphene growth was inaugurated and is now producing high quality layers on all available 4H(0001)/6H(0001)/3C (111)-SiC surfaces [Carbon]. Development of a novel methodology to prepare protein nanowires functionalized with light emitting, semiconducting, and magnetic materials. This allows us to use readily available starting materials to prepare functional protein nanowires to be incorporated in electronic and optoelectronic devices. The ferromagnetic state of Ni is shown theoretically and experimentally to withstand up to 260 GPa, the highest pressure where magnetism in any material has been observed so far [Phys. Rev. Lett. 2013]. This exciting result has been highlighted by ESRF. Pressure induced hydrogen bond symmetrization hydroxyl containing compounds, which has been elusive for four decades, is predicted theoretically and discovered experimentally [Phys. Rev. Lett. 2013]. Fast growth of nanoparticles in a hollow cathode plasma through orbit motion limited (OML) ion collection has been achieved [Appl. Phys. Lett. 2013]. 106 (175)
We have successfully developed growth conditions for chemical vapor deposition of SiC using methane (CH4) as carbon precursor, demonstrating high-quality material and excellent morphology. [Journal of Crystal Growth online 2013]. Using our novel aberration-corrected TEM we proved the existence of debated bcc-nisi phase (space group I- 43m 217, a=2.72 Å), forming by topotactic reaction in Ni/Si diffusion couples at 150-350, C. bcc-nisi transforms to NiSi2 with Ea ~0.6 ev Development and qualification of high yield printing processes for EC Displays and electrochemical transistors for the integration of electronic labels. Major scientific awards: Prof Hultman (AFM) and Prof Per Claesson (KTH) were jointly awarded the Akzo Nobel Science Award for their respective materials physics and chemistry, respectively, research on surfaces. Professor Mats Fahlman (AFM) was awarded the Göran Gustafsson price in Physics by the KVA. Daniel Aili was awarded the Arnbergska priset by the Swedish Royal Academy of Sciences. Lars Hultman awarded the prestigious 2013 Am Ceramic Soc. Ross Coffin Purdy Award best paper 2D Metal Carbides ACS Nano 6 (2012) 1322 107 (175)
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12. Strategiskt forskningsområde: Molekylär biovetenskap Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 65 115 190 190 190 Avsättning till infrastruktur 15 27 45 45 45 Budget efter avsättning 50 88 145 145 145 12.1 Science for Life Laboratory a national resource center for high-throughput molecular bioscience Huvudsökande: Kungliga Tekniska Högskolan 33,3% Medsökande: Karolinska Institutet 33,3%, Stockholms universitet 33,3% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 101 500 000 Personell 8 816 000 - Running costs 11 104 000 Co-funding from-co-applicant higher education institution 5 029 000 High cost Equipment 3 351 000 Funding from collaborating research institutes - Infrastructure running costs 56 375 000 Funding from other collaborators - Other costs 21 853 000 Other external funding 300 000 000 Totalt: 101 499 000 Totalt: 406 529 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Source Sum Tkr EU 30 000 National funding and foundations 111 000 Other International funding 21 000 Other Private Companies 54 000 Other 84 000 Grand Total 300 000 109 (175)
Please state the main priorities within the environment in 2013. (Question Q1) For SciLifeLab 2013 has been a year of reorganization, but it has also been a year when the structure and organization of the center has settled. With the two parallel sources of funding (SRA and national funding), SciLifeLab has developed into a true national resource providing technologies and services, complemented with an interdisciplinary research environment and with the ambition to maintain Sweden s international competitiveness in the field of molecular biosciences. The two sources of funding are important for SciLifeLab. The host universities, together with SciLifeLab, are using these to create a strong technology resource and a strong research environment. Both sources of funding benefit from each other and it is important to maintain this structure. As before, an important priority for SciLifeLab Stockholm during 2013 has been to continue to build a strong infrastructure in large-scale bioscience and to increase the awareness of the infrastructure among the research community in Sweden. In 2013 several new platforms were started complementing earlier platforms, including a new Clinical genomics platform and a dedicated platform for Drug Development, as well as a new facility for Mass Cytometry. In order to make sure that the platforms deliver services that are relevant on a national level, the National Reference Committee have been engaged for evaluation. The approved platforms has moved to national funding and the earlier SRA funding for these has been used to start new facilities and to recruit new group leaders. We continue to focus on accessibility to the resources for all academic researchers in Sweden, actions for knowledge transfer, educational efforts and facilitating for guest researchers to temporarily work at SciLifeLab Stockholm. One of SciLifeLab s missions is to support the translation of new findings, methods and technologies into products for industry, health care or the environmental field. This is a continuous work on several levels and SciLifeLab is creating new ways to collaborate with industry and health care. As the center is based on two sources of funding in addition to the large number of independent researchers, an effective administrative organization is required. This is being done in collaboration with the host universities and will continue in 2014. Please describe the major activities within the environment in 2013. (Question Q2) During 2013, SciLifeLab Stockholm has expanded substantially. The expansion is almost completed with 14 000 square meters and around 500 persons. Some free space is still available and SciLifeLab is working to recruit research groups to complement and strengthen the center. A major activity during 2013 has been to reorganize the center to optimally use the two sources of funding, a work that was almost completed during the year. The infrastructure has developed in several ways during the year, mainly due to the new source of funding for the national resource. New platform facilities have been established at SciLifeLab and several of the existing platforms have developed further. Substantial external funding has enabled investments in new instrumentations and recruitment of personnel to individual facilities. The productivity in research has developed well and in 2013 around 200 peer-review manuscripts were published in scientific journals. The broad field of bioinformatics continues to be very important. The SciLifeLab Stockholm environment now has over 150 persons working in this field. However, a goal is to further expand the advanced bioinformatics support within the platform activities. Please describe the major results within the environment in 2013. (Question Q3) The year of 2013 has been a fruitful year for SciLifeLab in Stockholm. There have been important achievements both regarding the infrastructure as well as in research. One main goal for SciLifeLab Stockholm 110 (175)
has been to, based on the new funding, build an infrastructure with technical platforms serving the Swedish research community. In addition to the assignment to serve as a national infrastructure, the ultimate goal for SciLifeLab is to generate excellent research results and new knowledge. SciLifeLab researchers perform research on an internationally high level. This has resulted in more than 60 first-rate publications over the year and several patents being filed. These cover a broad range of molecular bioscience research. Considerable parts of the research being performed is focusing on an increased molecular level/mechanistic understanding of human diseases, plants, and microbes, finding new biomarkers for disease and development of new treatments. The outcome of this research is many times heavily dependent on method and analysis development also performed within the centre. There are several results from SciLifeLab in Stockholm that is outstanding. Among these can be mentioned solving the 20 Gb genome of Norway spruce, identifying a novel mechanism on how epigenetic anti-cancer drugs result in cancer cytotoxicity, decoding the mechanisms behind gene expression by analysis of DNAbinding proteins, mapping of 263 previously unlocalized proteins to individual compartments in the cell, and integration of RNA and protein expression data corresponding to approximately 80% of the human proteincoding genes as well as classification of these genes with regards to tissue-specificity and spatial expression pattern. All these results have been published in high-impact journals. 111 (175)
12.2 SciLifeLab, Uppsala (Center for genomic and proteomic medicine) Huvudsökande: Uppsala universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 43 500 000 Personell 28 880 000 141 547 152 Running costs 2 800 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 7 618 157 Funding from collaborating research institutes 3 000 000 Infrastructure running costs - Funding from other collaborators 107 359 367 Other costs 4 201 843 Other external funding 443 033 000 Totalt: 43 500 000 Totalt: 738 439 519 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Specification of Other external funding Types of funding sources: Funding from public agencies 49% Public research foundations 4% EU-framework programmes and other international funding 18% Private non-profit organizations or private companies 27%. Please state the main priorities within the environment in 2013. (Question Q1) In 2013 the main priority for SciLifeLab Uppsala has been to facilitate the merger with SciLifeLab Stockholm in a National SciLifeLab Center. This has entailed the development of a completely new organizational structure and management where the two nodes in Uppsala and Stockholm work together in a highly coordinated way. Platform facilities have been evaluated for national status and facilities in Uppsala and Stockholm have been more closely aligned to form national platforms with common steering boards. Furthermore, coordination around the recruitment of SciLife Fellows, young outstanding scientists, has been initiated and the first round of recruitments has already come quite far. Common efforts of community building, outreach to health care and industry have also been strengthened. The key mission for the National SciLifeLab is to make advanced and/or large-scale molecular technologies accessibility to the resources for all academic researchers in Sweden, but the charge also includes actions for knowledge transfer, such as educational efforts and for facilitating interactions with society and industry. The National Board, SciLifeLab Leadership and the National Reference Committee (NRC), with broad representation from Swedish universities, spent a considerable amount of time and effort on these matters in 2013. 112 (175)
In parallel with this coordination effort, the core mission of continuing to build a strong infrastructure in largescale bioscience, and efforts to increase awareness of this infrastructure in the Swedish research community have been ongoing. In Uppsala the technology platforms now consist of 21 facilities for users in a broad range of areas, of which 14 received national facility status and 7 are regional facilities of national interest. This includes several new/pilot facilities being developed to explore new cutting edge technologies such as single cell genomics and proteome analysis and biomaterials as well as facilities to translate both sequencing and biomarker analysis into clinical use. The grants awarded by the Wallenberg Foundation in 2012 have also been used to further strengthen the platforms offering genomics and bioinformatics support. In addition, an important priority has been to continue to develop the dynamic interdisciplinary research environment of SciLifeLab in Uppsala. Currently >850 scientists in Uppsala are part of this community. During 2013 we have continued to actively invite scientists from other Swedish universities to join the SciLifeLab community in order to ascertain strong scientific ties across Sweden. Our strategic recruitment of scientist adding to the competence and interdisciplinary research environment has now been extended into a joint effort by the four host universities of recruiting SciLifeLab Fellows. We have also focused on supporting the translation of new discoveries, methods and technologies into products/services for industry, health care or the environmental field. An important aspect of such stakeholder interactions has been to set up the new Clinical Diagnostics platform, focusing on both Clinical Sequencing and Clinical Biomarkers. In addition, UU Innovation, together with KI Innovation, has been working to establish a joint innovation model SciLife Innovation helping to identify and fund projects shared between academia and industry. During 2013, the SciLife Innovation project has received funding for two pilot projects from Vinnova. This complements the already established the AIMday concept where companies submit questions and academic scientists respond in a workshop forum. Please describe the major activities within the environment in 2013. (Question Q2) In 2013 SciLifeLab Uppsala has continued to expand. The center now includes 850 people, more than 200 of which are platform staff (a ~25% increase in 2013). To accommodate this and a more interactive environment, a new building has been constructed and taken into use. The genomics and bioinformatics platforms have moved into the adjoining space to be near each other and the interactive space at the new hub building. SciLifeLab Uppsala s largest activity has been the 1,293 projects performed at the technology platforms, with the aim to provide service for national and local scientist. The platforms have also devoted much effort to education on technologies offered by the platforms (~40 courses) as well as subsequent data analysis. Inaddition, a substantial amount of technology development has been performed to enable novel insights in biologyand medicine, resulting in multiple high-profile technology development publications. Generally, the infrastructure has been developed and expanded in several ways during the year. Major emphasis has been placed on developing the Drug Discovery end Development and Clinical Diagnostics platforms now shared with Stockholm. The pilot platforms Single Cell and Biomaterial characterization has continued to solidify their services. Substantial SciLifeLab and external funding has enabled investments in new instrumentation and recruitment of personnel to the facilities. Since the platforms encounter an increasing demand from researchers and customers, much effort is put on simplifying the routines for using the resources with a new web portal for genomics as an easy-to-use single-entry point for the joint genomics facilities in Uppsala and Stockholm. The recruitment of top-level researchers is key and the Uppsala strategic recruitment process has been converted into the national SciLifeLab Fellow program. Two SciLifeLab Fellow recruitments in molecular medicine and molecular biosciences are underway, and attracted a record number of applicants, with a large international spread. Industrial partnership was also a priority in 2013 and AstraZeneca funded 10 major 113 (175)
collaborative grants within the framework of SciLifeLab, three of which are led by Uppsala PIs. One of the PIs is one of our recent SciLifeLab strategic recruitments. SciLifeLab has continued to develop concepts for collaborations between academia and industry. The AIM Day concept has been further expanded and utilized in 2013 with AIMdays in Diagnostics and Biomarkers and CNS Disorders resulting in 6 new collaborations, possibly more. As an alternative method for fostering collaboration, UU Innovation and KI Innovation has developed a new concept SciLife Innovation, to generate new collaborative projects. A pilot with two projects shared between academia and industry has received funding from Vinnova. Please describe the major results within the environment in 2013. (Question Q3) SciLifeLab is internationally competitive based on its combination of platforms for large-scale bioscience and applications of these resources to both large-scale and hypothesis driven smaller research projects. We are excited to note that this year Uppsala University moved up in the Times Magazine international ranking of Universities. UU now is in the 38th place in the world and the best Swedish university in Life Sciences. This flattering evaluation coincides with a large increase in both platform productivity and publication output. The technology platforms of SciLifeLab Uppsala have performed 1,293 research projects, > 35% of which were led by a principal investigator from outside of UU. This is a substantial increase over the ~700 project performed in 2012, ~ 500 projects conducted in 2011 and ~300 in 2010.Furthermore, the projects have increased in size, with expanding numbers of samples analyzed perproject. The largest platforms have been bioinformatics (521 projects) and genomics (328 projects). Other platform facilities have also performed a large number of projects and performed extensive training including for both external and internal users. Besides the important mission to serve as an infrastructure, the ultimate goal for SciLifeLab is to generate excellent research results and new knowledge. SciLifeLab Uppsala scientists have published 234 publications specifically citing SciLifeLab, an 80% increase from 2012. This includes 95 papers published in journals with an impact factor >6 and 15 with an impact factor >30 including Nature, Science and Nature Genetics. Highlights from these papers include 1) genome sequencing to find adaptations underpinning the domestication of dogs (Nature), 2) a better understanding of the genetic basis for obesity (Nature Genetics), 3) comparative genome sequencing and analysis of self fertilizing plants shedding light on how this trait influence their evolution (Nature Genetics), 4) new methods to sequence transcripts in histologically preserved cells (Nature Methods) and 5) tools to measure movements and binding of biomolecules in living single cells (Nature Methods). Overall, the research covers a broad range of molecular bioscience. Considerable parts of the research is focusing on an increased understanding of human diseases as well as into molecular-level insights about plants and microbes at the molecular level, and the search for new biomarkers for disease, and development of new treatments. By its nature the outcome of this research often crucially depends on high performance computing and informatics support provided within the center. The research community of SciLifeLab Uppsala has now surpassed 850 members and activities related to interactions with the clinic and industry continue to increase. In fact, the number of companies interacting with the SciLifeLab environment increased to more than 44 in 2013. The number of publications produced by the community as a whole surpassed 850 this year and external funding topped 440 million SEK. In addition a record high number of Wallenberg Fellow & Scholar and ERC Investigator Awards were given to SciLifeLab Uppsala (3 awards 2011, 6 awards 2012 and 9 awards in 2013), suggesting that the research environment indeed successfully promotes excellent research. 114 (175)
13. Strategiskt forskningsområde: Nanovetenskap och nanoteknik Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: Vinnova År 2010 2011 2012 2013 2014 Total budget 30 45 80 80 80 Avsättning till infrastruktur 8 11 20 20 20 Budget efter avsättning 22 34 60 60 60 13.1 Chalmers Nano-initiative Huvudsökande: Chalmers Tekniska Högskola 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 33 191 000 Personell 21 398 000 Co funding from main applicant higher education institution 16 596 000 Running costs 8 384 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 157 000 Funding from collaborating research institutes 0 Infrastructure running costs 1 274 000 Funding from other collaborators 0 Other costs 7 193 000 Other external funding 0 Totalt: 38 406 000 Totalt: 49 787 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Chalmers has chosen not to report the amount of external funding above because of the difficulty to produce figures that accurately reflect the funding situation in the strategic research area (SRA). This has several reasons, for example: (i) a fairly large portion of the researchers are involved in more than one AoA and their external grants might partly or entirely be used for projects in other areas, making it difficult to determine to what extent the external funding should be attributed to one or the other area, (ii) some researchers are involved in research within the area, but not directly associated with the AoA, and therefore do not report their results or external funding here. Also, (iii) external funding received by researchers involved in the area at our partner universities is difficult to determine and to include in a relevant way. During 2013, Chalmers has investigated and considered several different models for reporting external funding to these environments, both by internal analysis and by conferring with some of the other involved Swedish universities. We have recently decided on a model for reporting external funding in a satisfactory and authentic 115 (175)
way and will use this for reporting for the entire period of 2010-2013 during the self-evaluation in spring of 2014. Please state the main priorities within the environment in 2013. (Question Q1) In 2013 we continued to prioritize community building, quality raising and utilization activities. A natural, important topical priority for us has been graphene research which has resulted in great deal of industrial and academic contacts both nationally and internationally; our success with the Graphene Flagship has presented us with several opportunities which we are capitalizing at this time. Please describe the major activities within the environment in 2013. (Question Q2) In the summer of 2013 we organized a community building activity in Marstrand on the Swedish West Coast, which brought together principal investigators, other senior researchers, young researchers and students across disciplinary boundaries. During two days we interacted socially and scientifically among the Chalmers community and with a group of top level international experts who gave a number of stimulating guest lectures (Carlo Beenakker, Thomas Bjørnholm, Louis Brus, Eleanor Campbell, Byung Hee Hong, Reiko Kuroda, Stefan Löfås, Charles Marcus, Pontus Nordin, and Herre van der Zant). On November 28-29 we organized the initiative seminar DNA in Nanotechnology and an associated workshop covering topics ranging from DNA-nanoconstructs with mobile light-controlled subparts to single molecule studies of the human genome and how this can help solving future challenges in life science and sustainable energy development. The workshop gathered outstanding speakers from academia including the founder of the field of DNA nanotechnology, Professor Nadrian Seeman (NYU), the director of the Kavli Nanoscience Institute in Delft, Professor Cees Dekker, and, from interdisciplinary nanoscience center, inano, in Aarhus, Professor Kurt Gothelf. The scientific part was followed by 170 registered participants from all around. Moreover, the program included a popular science part and a career session to which high-school students could register and attend. We had a limit of 350 places in this high-school student category due to the number of seats in the lecture hall. More than half of the places were covered already at the first day of registration and we even had to decline some 200 persons in this category. We are very happy that we got the chance to spread knowledge in nanoscience to such a large audience of stimulated high-school students and hope to have contributed to their future interest in science in general and in nanoscience in particular. The seminar days were a huge success both scientifically and education/dissemination wise, moreover, we anticipate that the connections between Chalmers and the international research community of DNA-nanotechnology have strengthened significantly. As a means to focus attention to and promote quality of research, we have used a private donation to establish Arne Sjögren s Prize for the best doctoral thesis in nanoscience and nanotechnology, which was awarded for the first time in 2013 to Dr Samuel Lara Avila for his work on graphene-based devices. A second example of activities with a clear excellence focus is hiring on new faculty, where we recruited a new Assistant Professor in the area of metamaterials, and have recently made an offer to an internationally leading graphene chemist. Our utilization activities were strengthened by hiring a second industrial post-doc (jointly with Hot Disk AB). This was the second postdoc in the program that was started in 2012 and will continue in 2014 through a third postdoc, to be financed jointly by us and AstraZeneca. Another theme of utilization was a series of workshops and lectures to Swedish industries and decision makers on the technological potential of graphene. A specific measure in this direction was the inauguration of the Chalmers Graphene Center in connection with the visit at Chalmers by a delegation of the Royal Swedish Academy of Engineering Sciences, including His Majesty Carl XVI Gustaf. The graphene center includes a Graphene Innovation Lab (partly funded by the regional government in Western Götaland, VGR) as a dedicated academia-industry interface to boost utilization of the new technology. The latter series of activities is naturally directly connected to our role in the Graphene Flagship. 116 (175)
Please describe the major results within the environment in 2013. (Question Q3) The start of the Graphene flagship funded by the European Commission which is coordinated from Chalmers by Prof. Jari Kinaret is a great success for Chalmers, and a direct result of the activities within the Area of Advance for Nanotechnology and Nanoscience. We have recruited several young researchers during the year which will be described under B4a) A number of important scientific research results have been published during 2013, these are presented under D1a). We have also continued our work to create a we-feeling among the nano researchers and increase the collaboration, especially between physics and chemistry. In May 2013 we had a community building activity in Marstrand, with a number of very good lectures and team building activities. 117 (175)
13.2 The nanometer Structure Consortium at Lund University Huvudsökande: Lunds universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 27 154 000 Personell 11 181 000 30 026 000 Running costs 6 171 000 Co-funding from-co-applicant higher education institution Funding from collaborating research institutes 0 High cost Equipment 0 Infrastructure running costs 8 949 000 0 Funding from other collaborators 0 Other costs 2 995 000 Other external funding 81 791 000 Totalt: 29 296 000 Totalt: 138 971 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Distribution of other external funding: VR (Swedish research council) 33 715 9.09 % Other public research agencies 8 290 2.23 % EU (both framework programs and ERC) 18 178 4.90 % Swedish Foundation for Strategic Research 8 489 2.29 % Knut and Alice Wallenberg Foundation 960 0.26 % Other Foundations 2 818 0.76% Region Skåne 74 0.02 % Private Companies 8 414 2.27 % Others 853 0.23 % Please state the main priorities within the environment in 2013. (Question Q1) Scientific research. The overall main priority of nmc@lu is our scientific research. Our main results are described in Q3 below. Important new initiatives are described in B1c. Vision and Mission. In a bottom-up process involving all parts and levels of our environment, we developed a Vision and Mission Statement for nmc@lu: Vision: To be a world-leading research center that uses the unique opportunities offered by nanoscience to advance fundamental science and to address society s grand challenges. Mission: Bringing together the most creative scientists, students and industry in an interdisciplinary research environment to do cutting-edge research on the materials science, physics, chemistry and safety of designed functional nanostructures for energy, opto/electronics and life science applications. 118 (175)
Flagship nanoscience center. We have continued to work with Lund University leadership, the faculties, as well as with the nmc@lu members, towards our aim of the establishment of a permanent, formal Nanoscience institute as a tangible result of the first five years of SRA support. Nanoincubator. We have started the process to gather financial and political support for the establishment of a nanoproduction facility (Nano Incubator), with the vision to create in our region an international focal point for academic research, start-up companies and industry for semiconductor-nanowire enabled devices and applications. Nanoscience and innovation. During 2013 we enhanced our emphasis on innovation by forming Nanovation, a new focus area within nmc@lu, with the aims to promote our interactions with industry; to identify product opportunities for our scientific results; and to facilitate IP protection. Doctoral internship program. We have begun the development of an internship program for our PhD students. Starting with a core group of 12 PhD students (and with support from the major EU FP7 Innovative Doctoral Program PhD4Energy ), the longterm aim is to offer all of nmc@lu s PhD students the opportunity to perform an internship in nanotechnology industry as part of their education. Please describe the major activities within the environment in 2013. (Question Q2) Major activities (beyond our research, described in Q3) concerning the SRA as a whole include: We developed and launched a new website for nmc@lu (www.nano.lu.se), a major effort involving all parts of nmc@lu. A multi-day retreat for all members of nmc@lu was used for networking, the joint definition of research priorities and directions, the development of a Vision and Mission statement, and future strategic priorities. Our 2013 annual meeting focused on Novel Characterization Methods in Nanoscience, and was attended by more than 150 nmc@lu scientists and representatives from the University, society and industry. We celebrated the 25th anniversary of the Nanometer Structure Consortium, making us one of the world s earliest Nanoscience Centers. We were visited for three days by our Scientific Advisory Board who interacted with the coordinators for all of our 10 focus areas, the executive group and with PhD student representatives, and who offered detailed and highly valuable advice. We organized the interdisciplinary summer school Our Toolbox in Nanoscience where about 40 nmc@lu PhD students learned the foundations of all the major characterization methods and facilities available within Lund Nano Characterization Labs, an nmc@lu focus area. The 5-year education program Engineering Nanoscience celebrated its 10th anniversary. This LTH program was founded by nmc scientists and closely integrates nmc@lu scientific research with undergraduate and masters level education. In major developments going beyond the boundaries of nmc@lu, our spin-off companies SolVoltaics (nanowire-based photovoltaics) and Glo (nanowire-based light-emitting diodes) have continued to attract major private investments (102 MSEK and 150 MSEK during 2013, respectively). Crucially, our spin-off company Glo (now with more than 70 employees) has begun to generate revenue. Please describe the major results within the environment in 2013. (Question Q3) During 2013 we published more than 150 scientific articles. In the following, we highlight a small selection of the most important results in each of our focus areas. * Materials Science: Our efforts on in-situ TEM studies of nanowire growth have led to important new insights, including on the control of aerotaxy-like growth of InAs nanowires on amorphous substrates, and on how to achieve stable growth conditions for GaP nanowires (published in Science). * Quantum Physics: We developed methods for the use of thermopower measurements in quantum transport, and identified thermopower signatures of many-body effects and of Majorana states in nanostructures. In quantum information technology, we increased optical cavity Q-values by more than four orders of magnitude by spectral engineering. 119 (175)
* Nanoelectronics/photonics: We developed an optical method for determining length and diameter of NWs in arrays, allowing in-situ feedback during growth. We have achieved a quantitative microscopic description for the intersubband lineshape for quantum devices. * Nanoenergy: Building on the techniques used for our world-record solar-energy harvesting efficiency using nanowires (published in Science), we applied nano-imprint lithography for wafer-scale photovoltaic and light-emitting devices. We demonstrated, for the first time, a strong enhancement of the thermoelectric power factor by quantum confinement in NWs. * Nanosafety: We identified the proteins that drive nanoparticles/protein aggregation in blood serum and the mechanism behind protein driven aggregation. We developed and implemented methods for directly depositing nanoparticles from gas phase on lung cells to mimick deposition conditions in the lung. * Neuronanoscience and Nanobiology: An implantable, ultra-flexible, multichannel electrode for nanowire based sensing structures showed promising recording properties. We have also developed fluorescent barcoded nanowires for safety studies. Using fluorescent actin filaments propelled by myosin motors, we discovered a light guiding effect in nanowire arrays that will enable much more sensitive biosensing devices. * Lund Nano Lab: A range of urgently needed new equipment was installed. Novel processes developed include nanoimprint lithography allowing time-efficient patterning for the growth of regular nanowire arrays on large areas, selective electroplating of Au for NWs growth, greatly reducing the cost for Au in future nanowire-based device applications. * Lund Nano Characterization Labs (LNCL): Single attosecond XUV laser pulse generation was coupled with nanoscale imaging instrumentation. Ultra fast optical studies of semiconductor nanostructures and measurement platforms were developed. Funds were obtained for a new environmental TEM for in-situ studies of nanowire growth. 120 (175)
14. Strategiskt forskningsområde: Neurovetenskap, inklusive hjärnans och nervsystemets sjukdomar Huvudansvarig myndighet: Samrådande myndighet: Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 25 40 70 70 70 Avsättning till infrastruktur 5 8 14 14 14 Budget efter avsättning 20 32 56 56 56 14.1 Cognitive and Motor functions in Health and Disease during the Lifespan Huvudsökande: Karolinska Institutet 86% Medsökande: Umeå universitet 10%, Kungliga Tekniska Högskolan 4% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 28 328 000 Personell 13 984 000 Co funding from main applicant higher education institution 13 571 309 Running costs 5 110 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 4 911 610 Other costs 4 186 000 Other external funding 115 252 728 Totalt: 23 280 000 Totalt: 162 063 647 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. Wallenberg 35%, VR 21%, EU (program and ECR) 14%, SSF 3,5% 121 (175)
Please state the main priorities within the environment in 2013. (Question Q1) Brain disorders are among the most common causes of disability in high income countries. In spite of the major impact on society, there is a lack of effective prevention and treatment. Our goal is to integrate research in clinical and basic neurosciences and focus on brain disorders causing cognitive and motor dysfunctions. As a part of this achievement, we strive to create a truly interactive, translational neuroscience milieu with an international reputation that will foster a new generation of leaders and scientists and attract academic and industrial partners. The research is based on three research programme areas: I. Basic mechanisms supporting motor and cognitive functions II. Neurodevelopmental disorders like developmental coordination disorders and cerebral palsy III. Neurodegenerative and neuroinflammatory diseases like Alzheimer s disease and Parkinson To achieve these goals we have made the following points: 1)Train students, to recruit young and talented researchers as well as provide initial support for them to build their own research groups 2)Increase interaction between the research groups and stimulate translational research by collaboration between basic and clinical research groups. Increase interaction across geographical sites. 3)Build cutting edge methods platforms and infrastructure 4)Support research excellence in the three research programmes 5)Make the research results useful for society Please describe the major activities within the environment in 2013. (Question Q2) Efforts have been made to strengthen the Research Program and advancement of specific strategic needs: During 2013 a call was launched with a specific focus on new collaborations between at least two research groups with the aim to combine distinctive and complementary approaches. During 2013 a call for a young investigator was issued. Emphasis was on a competitive researcher (male or female) preferably not from within StratNeuro environment and with research that complements StratNeuro activities. Doctoral courses in neuroscience and student-initiated activities are supported and improved. The following new doctoral courses, which are given annually at Karolinska Institutet, have been developed with the support of StratNeuro: 1) Brain circuits, 2) Brain development and neurodevelopmental disorders, 3) Frontiers in cognitive neuroscience, 4) Neurogenetics, 5)Neurodegenerative disorders I - from molecule to treatment With regard to student-initiated activities, StratNeuro supports the annual Ski Conference in Neuroscience, a 3- day conference in which doctoral students gather for an intense scientific programme with project presentations and discussions. Second, it supports the program "Promotion of new techniques and mobility" in which individual travel grants are awarded to doctoral students to visit a foreign laboratory to learn a new technique or to attend an international doctoral course not available in Sweden. A new mobility program for students was initiated during 2013, with the continuing aim for industrial and international visits in order to learn new techniques and make contacts. StratNeuro continue to support important technological platforms for neuroscience research such as: 1) translational neuroscience behavioural platform (to study effect on behaviour in normal and mutated mice strains), 2) a reprogramming laboratory (use of induced pluripotent stem cells, which are normal cells 122 (175)
reprogrammed to become stem cells, to investigate effects on cell level of different neuroscience disorders), 3) a zebrafish facility (used to investigate effects human genes by mutation in fish gene homologs), 4) Karolinska Brain Bank (access to human brain material), 5) brain imaging including micro-imaging for rodents (to study brain activity in animal models), 6) bioinformatics (use of genome sequences and gene expression information to facilitate neuroscience studies), and 7) radiation source for brain lesions mimicking radiotherapy (which is used in cancer treatment). Please describe the major results within the environment in 2013. (Question Q3) Scientist in StratNeuro has described several biological findings correlating with brain function or neurological diseases. Scientists have also participated in international collaborations identifying risk genes in Alzheimer, Schizophrenia or multiple sclerosis. Many of these studies build on access to high-quality infrastructure and StratNeuro work with national partners to develop structures for neuroscience. As example the: National Swedish Magneto EncephaloGraphy NATMEG was inaugurated with a conference in October 2013. The NATMEG facility facility is a new brain imaging infrastructure which will provide researchers and clinicians with state of the art structural and functional imaging of the brain. This enables us to look at brains structures with significantly increased sensitivity and resolution. Itsupported by universities in Lund and Linköping as wel StratNeuro.Three internationally recruited guest professor have been part-time active during 2013 in order to help with transfer of knowledge of analysis of MEG data. Neuroinformatics platform platform was further developed by introduction of new supercomputers at the Center for parallel computers at KTH.Much of experimental brain data comes in large volumes and also need advanced analysis. Though some standard analysis is feasible to run on ordinary computers and small clusters, some of the new analysis paradigms benefit greatly from being run with a high degree of parallelism on large cluster supercomputers. Likewise, computational models of brain circuits and systems are developing rapidly. The simulators parallelize and run very well on large clusters so here as well the use of supercomputers is well motivated. Human cellular reprogramming laboratory (HCRL)has together with Umeå branch of StratNeuro converted fibroblasts (a type of cells in the connective tissue) from amyotrophic lateral sclerosis (ALS) patients into induced Pluripotent Stem cells (ips). These stem cells are derived from adult cells (in this case fibroblasts) by reprogramming, bypassing the previous necessary step of deriving them from embryos. This project has yielded interesting results when it comes to the turnover of a certain protein (Superoxide dismutase protein, SOD1). The protein is not folded properly, i.e the three dimensional structure is not correct. This could be an important factor in the disease. The project above is an example that collaboration within StratNeuro is starting to bear fruit. KI Brain Bank was included in the common core facility program supported jointly by KI and Stockholms Läns landsting (SLL) demonstrating strategic importance, for both research and for health care. It is of significant importance for both research and health care to have access to high quality human brain material to be able to better define and understand disease processes on the morphological and molecular level. We have established intersectional genetics methods, transgen optogenetic methodology and set up CLARITY (Clear, Lipid-exchanged, Anatomically Rigid, Imaging/immunostaining compatible, Tissue hydrogel) as a method for clearing and analysing brain tissue. This is a very promising technique to achieve a global brain mapping and to enhance our understanding of normal brain structure. During 2013 the International Scientific Advisory Board (ISAB) delivered an evaluation report with recommendations to further develop the research program, infrastructures, training, innovation and a young investigator program. ISAB is chaired by Nobel Laureate Prof Torsten Wiesel and also include Profs Riitta Hari, John Krystal, Olle Lindvall, Marc Tessier-Lavigne and Gerald Fischbach. 123 (175)
14.2 Multidisciplinary research focused on Parkinson s disease MultiPark Huvudsökande: Lunds universitet 97% Medsökande: Göteborgs universitet 3% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 28 160 000 Personell 15 547 564 40 313 848 Running costs 5 451 072 Co-funding from-co-applicant higher education institution 469 200 High cost Equipment 7 349 628 Funding from collaborating research institutes 0 Infrastructure running costs 48 193 Funding from other collaborators 0 Other costs 3 478 477 Other external funding 107 403 766 Totalt: 31 874 934 Totalt: 176 346 814 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. The other types of funding sources are: 1) Swedish Research Council 44% 2) European Union Funding (ERC, Frame work programme) 23% 3) Other Swedish Foundations 7% 4) Other foreign organisation 6% 5) Crafoord Foundation 5% Please state the main priorities within the environment in 2013. (Question Q1) Apart from the overarching priority of improving the quality of life for Parkinson s Disease (PD) patients; and the ongoing priorities such as performing translational research and promoting entrepreneurial efforts - there have been two more specific priorities within MultiPark (MP) during 2013. Firstly, a lot of effort has been placed in the process of developing a new strategic plan for MP outlining the future for the environment beyond the current funding period in terms of scientific focus and organizational structure. This process will continue during 2014, with the aim of ratifying the new strategic plan in May, to be valid during the period 2014-2019. In order to provide core input to the joint effort to develop the new strategic plan of MP, priority has been to consolidate translational working groups formed around each specific aim of MP. The groups are convened by two members that each represents one of the main types of research included in MP (experimental, clinical, health science), thereby providing insights from different perspectives on a joint aim. 124 (175)
Please describe the major activities within the environment in 2013. (Question Q2) There have been numerous activities within Multipark during 2013, for instance involving research collaborations, recruitments, and education. RESEARCH ACTIVITIES 1) Numerous studies targeting PD and related disorders, for instance on when, and how non-motor symptoms develop during the PD disease process; how to treat non-motor symptoms; occurrence of non-motor symptoms in atypical Parkinsonism; the relation between non-motor symptoms and Health-related quality of Life. 2) Preparations for the start of the Transeuro Clinical neural transplantation study. 3) Established a collaboration platform for studies on health economy aspects on PD on basis of the Parkinson Patient Registry a collaboration between the Swedish Institute for Health Economy, MP, and pharmaceutical industry. 4) Initiation of the EU Joint Programme - Neurodegenerative Disease Research (JPND) project CLASP a European collaboration to analyze the situation for the most severely sick PD patients and suggest improvement in care and treatment. 5) Patient enrollment in the project MIND. Performed analyzes of mitochondrial activity in blood cells of a large number of patients with neurodegenerative disorders. 6) Launched a new EU project (NeurostemcellRepair) with the aim to produce clinical grade ES cell. 7) Established in vivo conversion of astrocytes to neurons within the brain. 8) Launched a new EU project, (MultISyn) aiming at developing a novel imaging platform for the study of familial PD, focusing on alpha-synuclein aggregation. 9) Performed explorative studies comparing people ageing with PD with matched controls, identifying diseasespecific needs that nurtured the development of the "Home & Health in PD" project, for which the data collection was completed. 10) Contributed to the European guidelines on physiotherapy for PD. 11) Completed the first task of the EC-financed Innovage Project, involving patients with neurodegenerative disorders in the research process. 12) Started a translational project, funded by MP with the aim of investigating physical training as a rehabilitation strategy in PD. 13) Initiated a strategically and scientifically important collaboration with MAX Labs at Lund University (LU). RECRUITMENT 1) Appointment of a professor in clinical neuroscience. 2) Appointment of a part-time innovation officer. INFRASTRUCTURE 1) Funding has been provided in order to further reinforce the investments made in 2012; such as expensive technical equipment, research nurses and project administrators to support field work/data collection in clinical and health sciences projects. 2) The MP-financed biobank has finalized the establishment of the infrastructure for sampling and started recruitment of personnel. 3) The National Swedish Parkinson Patient Registry (ParkReg) started in 2012, and has during 2013 continued to enroll patients and by the end of the year, approximately 600 patients were registered. INNOVATION 1) The MP Innovation Group seeks out innovations and grants financial support for scientists to develop and validate ideas. During 2013 three innovation grants have been awarded each of 200,000 SEK. 2) Several scientists have been the inventors of patents, and have close collaborations with industry. A survey of innovation activities, initiated by the Innovation Group and Innovation officer has been performed. 125 (175)
3) Engagement in a VINNOVA-financed health care test-bed project. EDUCATION 1) A course entitled Scientific Illustration Techniques (2.0 ECTS) was organized in collaboration between Lund University Neuroscience graduate school and Lund Research School in Stem Cell Biology. 2) A new course entitled MultiPark translational study design has been created, which runs until spring 2014. 3) Lund s part of the Scandinavian Education for Movement Disorder Specialists Rare Movement Disorders was performed. DISSEMINATION 1) An introductory film about MP and 9 researcher presentation videos have been developed for the MP website and other media channels. 2) A Swedish website aimed at the general public has been launched (http://www.med.lu.se/multipark/paa_svenska). 3) The MP YouTube Channel has been launched (http://www.youtube.com/channel/uc72wl3zmqs2epm2gmgzsspg). 4) Several publications have provided headings for major newspapers and TV-shows, nationally and internationally. STRATEGIC DEVELOPMENT ACTIVITIES 1) During the year there have been several strategic workshops and meetings with a core group within MP in order to plan for the strongest possible future of the research environment. 2) MP has organized a recurring annual retreat. 3) A new seminar series has been launched, once a month aimed at bringing researchers together from the MP environment and exchanging ideas. Please describe the major results within the environment in 2013. (Question Q3) There have been many exciting and strong results from MP during 2013, such as numerous publications and great success in receiving prestigious research grants, confirming that MP researchers and the strategic research area are highly competitive both nationally and internationally. RESEARCH RESULTS Highlighting some of the research findings from the environment during 2013, MP investigators have made the following discoveries and developments: 1) Found new evidence to support the prion-like hypothesis for the spread of PD in the brain of affected individuals. 2) Developed a new strategy to convert patient somatic cells into neurons for cell transplantation purposes. 3) Developed novel methodologies based on the use of viral vectors which allow for a better targeting of brain cells, and delivery of therapeutic agents. 4) Found new cellular targets that can be modulated to rescue midbrain dopamine neurons from alphasynuclein toxicity. 5) Development of in vitro and in vivo systems for drug discovery, and identification of a compound, Rasagiline, that improves olfactory deficits in an alpha-synuclein mouse model of PD (for the latter, a patent is filed). 6) Found indications that non-motor features of PD such as depression, fatigue, and cognitive impairment are associated with inflammatory molecules that can be detected in the cerebrospinal fluid of patients. 7) Comparing people with PD with matched controls, found that they had more housing accessibility problems (HAP), generated by the complexity of their profiles of functional limitations. The specific environmental barriers that contribute to their HAPs were identified, as were their unmet needs for assistive devices. 126 (175)
Furthermore, within the Faculty of Medicine at LU, two, so called Creative Environments have been formed focusing on PD. These are translational groups targeting research on PD focusing on cognition and stem cells. This is a funding initiative from the Faculty with the aim to strengthen and stimulate translational research, with an emphasis on support of younger scientists. INNOVATIONS There are two innovations within MP that have led to pharmaceutical companies filing for patents. There are also several clinical trials being planned based on results from MP. Methods developed by MP researchers are also being utilized by the industry. During 2013, progress has been made in the InnovAge project, by the active involvement of people with neurodegenerative disorders in the introductory phase aiming at the development of a new ICT tool for housing provision that takes the needs of people ageing with disabilities into account. RESEARCH GRANTS Following are some highlights of grants awarded to MP investigators: 1) ERC Advanced Grant (second person within MP receiving this prestigious award). 2) The EU Joint Programme Neurodegenerative Disease Research (JPND); 1.2 MSEK to the part led by MP researchers. 3) Swedish Research Council general call in Medicine and Health, a total of appr. 23 MSEK. 4) Swedish Foundation for Strategic research (SSF) for their programme Future research leaders, 10 MSEK. 5) FORTE, 1 MSEK for a project on knowledge transfer. 6) Swedish Research Council, with MP as one of the core partners within LU (coordinating university) The Swedish National Graduate School for Competitive Science on Ageing and Health, 15 MSEK. 127 (175)
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15. Strategiskt forskningsområde: Politiskt viktiga geografiska regioner Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: - År 2009 2010 2011 2012 2013 Total budget 15 15 15 20 20 Avsättning till infrastruktur 0 0 0 0 0 Budget efter avsättning 15 15 15 20 20 15.1 The Middle East in the Contemporary World Huvudsökande: Lunds universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 12 069 000 Personell 8 479 000 Co funding from main applicant higher education institution 12 283 000 Running costs 1 311 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 75 000 Funding from collaborating research institutes 0 Infrastructure running costs 833 000 Funding from other collaborators 0 Other costs 3 355 000 Other external funding 5 836 000 Totalt: 14 053 000 Totalt: 30 188 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Distribution of external funding: The Swedish Research Council 30% The Royal Swedish Academy of Letters, History and Antiquities 30% Riksbankens Jubileumsfond 30% Other foundations 10% Please state the main priorities within the environment in 2013. (Question Q1) Research on the Middle East has existed in Lund since the university's founding in 1666, however the Middle East in The Contemporary World (MECW) strategic research area was established in 2009 with the aim of coordinating, redirecting, and expanding research at Lund University that is related to The Middle East and 129 (175)
North Africa region. MECW is the foundation for research and other forms of scholarship at the Center for Middle Eastern Studies (CMES). As elaborated below, major priorities within MECW in 2013 have included a thriving research environment, reorganization of research areas to better capture work of our researchers, strategic outreach, international collaborations, and development of a PhD program. During 2013 MECW has been working according to the following priorities: -THRIVING RESEARCH ENVIRONMENT Now that MECW has been a strategic research area for four years, we have reorganized our research environment to better capture the actual work of our staff and scholars -and to reflect the changes in rapidly changing Middle East area- instead of relying upon the formulation of MECW from the initial grant proposal (See Q2). -REORGANIZATION OF RESEARCH AREAS TO BETTER CAPTURE WORK OF OUR RESEARCHERS The initial research domains designed in the initial MECW grant proposal provided a good starting place but now there is a need to better reflect the organic work of scholars at CMES. Furthermore, the reorganization contributes to a better understanding of the events in the Middle East. -STRATEGIC OUTREACH MECW has a great track record with strategic outreach but during 2013 we focused more upon outreach to non-academic persons, organizations, institutions, agencies. -INTERNATIONAL COLLABORATIONS MECW continues to expand international collaborations, not merely across national borders but also across academic as well as non-academic organizations and institutions. -DEVELOPMENT OF PHD PROGRAM In addition to the existing masters program, there are plans for a PhD program. Please describe the major activities within the environment in 2013. (Question Q2) THRIVING RESEARCH ENVIRONMENT Activities taken to create a thriving research environment include: 1) creating permanent full time positions for researchers/teachers; 2) undergoing administrative re-organization (including the creation of new board of directors); and, 3) building a respectful research community. 1) Permanent Full Time Positions for researchers/teachers CMES/MECW announced one permanent and full time position as assistant professor in 2013. The position was defined as assistant professor in Middle Eastern Studies with a specialization towards sociology. This position will be filled in early 2014. In the fall of 2013 the new board of CMES/MECW took a decision to announce two permanent and full time positions. The positions will be announced in early 2014. All three positions replace post doc positions or positions as senior scholars, but positions that werelimited in time and contribute to an institutionalization of CMES/MECW. 2) Administrative Re-organization During 2013 a new board was announced and implemented in accordance with Lund University policies and regulations. Also, CMES/MECW worked closely with Human Resources officials at Lund University central administration to plan new administrative structure that would include one communication officer (100%). The new board also decided to have an assistant director of studies (100%) and financial officer (50%). Furthermore, CMES/MECW introduced development of work (apportionment) plan for academic staff. 130 (175)
3) A Respectful Research Community In order to achieve a respectful research community and enhance a sense of community among the people at the CMES, in 2013 CMES/MECW, initiated projects whereby the administrative staff were involved in activities like interviews and in findings ways to disseminate research project to the public. Similarly the students were given the opportunity to be co-researchers, co-authors, and co-presenters of scholarly work. REORGANIZATION OF RESEARCH AREAS TO BETTER CAPTURE WORK OF ACADEMIC STAFF Previously MECW was organized under the following domains: 1) Contemporary Interpretations of Islam and Muslim Cultures; 2) Hydropolitics, Security, and International Law; 3) Migration and Spatial Mobility; 4) The Middle East in Sweden; and, 5) Women for Sustainable Growth. While these domains were a good starting point for MECW research, they have come to be too rigid. Therefore, in 2013, serious discussions occurred to devise new research themes to capture the breadth of ongoing research. These themes are the following: Democratization of Social Development in the Middle East Physical and Social Sustainability in the Middle East Migration, Multicultural Societies and Minorities of the Middle East Religion, Processes of interpretation, and identity Formation in the Middle East STRATEGIC OUTREACH Major Strategic outreach activities of CMES/MECW during 2013 included: Working with Lund Municipality; organizing Malmö Field Week, becoming an institutional member of the Middle Eastern Studies Association of North America; working with the Stockholm-based, think-tank Timbro to set up a new project on Football and Identity Politics ; working with NGOs who focus upon marginalized youths (RGRA, Megafonen); organizing lectures and panel presentations for the Swedish Board of Migration, school officials, health care authorities, youth-based NGOs, humanitarian organizations, and various social forums. Furthermore, CMES/MECW organized major conferences that included: Conference of the Nordic Society for Middle Eastern Studies; 48 Hours of Syria (a mix of outreach and academic events) and co-organized Almedalen week events (for example Anna Hellgren, the communications officer of CMES was involved in the general organization of Almedalen week and CMES/MECW ran a six-hour long program -from lunch to eveningregarding the so-called Arab Spring and Muslims in Sweden). For more details about Strategic Outreach, see section D3 at the end of this evaluation. INTERNATIONAL COLLABORATIONS Our list of international collaborations grows longer every year. In 2013, collaborations included: Venice, Kaunas University, Short Term Visiting Scholar Award for the University of Nebraska Lincoln, Reza Arjmand s collaboration with Tehran University and Shahid Beheshti University involving exchange between researchers and institutions, Project on Asian in collaboration with Scholars from Norway, Russia, and Sweden at workshop at the Swedish Research Institute in Istanbul, Soran conference and continue discussions with universities under the Kurdish regional government in Northern Iraq, the Research, Advocacy and Public Policy (RAPP) Project in cooperation with the American University of Beirut, participation United Arab Emirates Workshop/Symposium to Promote Academic Research Collaboration between the UAE and Sweden, University of California Press edited volume regarding the Parallel States Project written by Palestinian and Israeli scholars and professionals, Hope Spoken/Broken project in collaboration among Swedish, Danish, and American Spoken-Word Artists, Workshops in Jordan regarding Arab Spring at the Center for Strategic Studies at the University of Jordan and at Yarmouk University s Refugee, Displaced Persons and Forced Migration Studies Center, Course (titled Refugees, Rights, and Realities ) developed with other Swedish universities through Universitet och svenska institute I samarbete för internationalisering (USI) together with Yarmouk University, Linnaeus University, and Gothenburg University. 131 (175)
DEVELOPMENT OF PHD PROGRAM In 2013 CMES/MECW established a PhD education committee Please describe the major results within the environment in 2013. (Question Q3) THRIVING RESEARCH ENVIRONMENT One Permanent Full Time Position for researchers/teachers was created, the hiring process is ongoing, and moreover two other positions are prepared to be offered in 2014. Through the election of new board, the administrative re-organization of the CMES/MECW has been accomplished in 2013. The creating of A Respectful Research Community is a work-in-progress but at this point both administrative staff and MECW scholars have a better understanding of and respect for the administrative work, teaching, and scholarship required to sustain a successful strategic research environment. REORGANIZATION OF RESEARCH AREAS TO BETTER CAPTURE WORK OF OUR RESEARCHERS The new reorganized research themes mentioned in Q2 are more fluid and overlapping. For example gender and generation now fall under any of the four research themes instead of being limited to one. What is meant by generation, can best be captured in the following way: Given the fact that 50% of the Middle East s population is below the age of 20, research concerning demography issues, conflicts between generations, patriarchy and hierarchy in regard to age etc. are scrutinized through generational perspective. There are no specific themes in regard to gender and generation. They are rather internalized in all themes. These research themes are not absolute but indicate the direction in which research at MECW is heading. These four themes or research areas also enhance multi-disciplinarity. One concrete result of the re-organization of the research themes is the one day final seminar of the Hydrosolodarity grant project, the seminar which took place during the spring of 2013 was titled Hydrosolidarity: The quest for Better Water Management in the Nile Basin STRATEGIC OUTREACH While in previous years CMES/MECW established itself among our academic peer institutions, in 2013 due to strategic outreach efforts CMES/MECW is becoming well-known beyond the confines of academia. INTERNATIONAL COLLABORATIONS CMES/MECW s international collaborations have grown to the point that CMES/MECW has become more selective for example the coordinator of MECW and director of CMES (Leif Stenberg) became a member of the research committee of the Norwegian Research Council. In addition to becoming more selective, similar to what was discussed in strategic outreach, we are including collaborations with non-academic organizations. For example, the UC Press edited volume regarding the Parallel States Project was not only written by scholars but included Palestinian and Israeli professionals. Furthermore, the Hope Spoken/Broken project involves collaboration among Swedish, Danish, and American Spoken-Word Artists. DEVELOPMENT OF PHD PROGRAM In 2013, the process of building the PhD program at CMES/MECW has started. 132 (175)
15.2 Uppsala Russian Research Center Huvudsökande: Uppsala universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 10 045 988 Personell 9 612 738 7 142 816 Running costs 1 025 980 Co-funding from-co-applicant higher education institution 0 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 4 191 627 Funding from other collaborators 0 Other costs 0 Other external funding 5 811 000 Totalt: 14 830 345 Totalt: 22 999 804 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Government strategic research funding: 2mKr has been balanced in from funding received in year 2009 Other external funding: public agencies (VR, SI, BrOM) 77%, public research foundations (RJ) 15%, EU-framework programmes (MC) 6%, international funding 1%, other non-profit org <1% Please state the main priorities within the environment in 2013. (Question Q1) The main priorities within the environment during 2013 have been to stay on course, to ensure that UCRS continues to improve on its international standing and to produce innovative research. The former has entailed organizing major international conferences with participation by top international scholars, and to sustain a steady flow of prominent guest speakers at weekly seminars. The latter has entailed a dynamic program of visiting fellowships to ensure that the research environment is conducive towards innovative interdisciplinary scholarship. A priority and a particular ambition have been to ensure that the Centre becomes fully integrated in Uppsala University s academic structures. A further priority has been to continue to ensure that our research meets the highest standards of academic rigor and to ensure that every scholar at the Centre can develop his/her area of specialization, both in terms of subject and of disciplinary affiliation. This helps to secure a high level of quality in research and also offers opportunities for the Centre to contribute to the university-wide 133 (175)
research environment, excellence in teaching, and public relations. All researchers are encouraged to publish the results of their research in books and international peer-reviewed journals. The research conducted at UCRS is regularly evaluated. In 2011, the research directors introduced the routine of demanding individual research reports at the end of every semester, in order to continually evaluate the results and quality of research according to transparent criteria. Each researcher employed by the Centre reports her/his publications, conference papers and other relevant activities (reports for the past four terms are attached).scholars from UCRS regularly present their research at international conferences, and numerous publications are in the pipeline that will add greater volume to our publication record. Important priorities during 2013 have also been to nurture already existing scholarly networks and to formalize emerging research cooperation with other leading universities and scholars in the world. In each thematic area, the Research Directors have striven to consolidate and strengthen the above mentioned areas. In the thematic area Identity Formation a particular priority during 2013 has been given to support and further strengthen four interrelated subareas and research tracks: Religion and politics in contemporary Russia, Post-Soviet memory construction, Nationalism as a political factor in Russia, and Human rights discourse in Russia. Since 2011, additional scholars specializing in these areas have been recruited to the Centre. International conferences, workshops and seminars, several of which have received competitive external funding and have thereby further contributed to a dynamic research environment. The research area is committed to the continued support and consolidation of these areas, while remaining open to the possibility of hosting new projects which are financially independent. In the thematic area State and Market efforts during 2013 have been made to consolidate already established scholarly networks and thematic depth, and to continue to conduct cutting-edge research on the prospects for and processes of post-soviet societal change, mainly in Russia. Specific issues concern economic transformation, democratic institution building, regional dimensions, problems of the legal system and historical legacies. These issues are explored from a variety of scholarly perspectives and disciplines, mainly economics, economic history, political science, sociology and law. Important priorities have also been to finalize a research project on Russian energy policy that will be published in 2014, and to start up a new project on the theme of Do Color Revolutions Really Happen? In the thematic area Russia s Neighboring Countries a particular focus during 2013 has been to further strengthen the research focus on the Baltic States, Central Asia, Ukraine and Moldova. Specifically issues related to research on minorities (ethnic, religious, sexual), nation-building efforts and policies historically and today, transformations at the elite and social level and state-building including party politics. Theoretically, the interplay between formal and informal institutions in these regions has become more accentuated, not least in the non-baltic parts. The South Caucasus has also been prioritized in 2013 (Georgia, Armenia, and Azerbaijan)., Challenges from a political, security and minority point of view of frozen conflicts, oil-and gas resources, statebuilding efforts and efforts in curbing corruption (Georgia in particular), as well as the outright authoritarianism and trouble of the opposition in Azerbaijan, have been researched, discussed and communicated through various channels. For the entire region, questions of the Eastern Partnership and the struggle between Russia and the EU, loom large and have been in focus of attention prompted by recent developments in EU relations with Armenia and Ukraine. Please describe the major activities within the environment in 2013. (Question Q2) The major activities within the environment during 2013 have been concerned with the successful organization of eight international conferences and workshops with participation by scholars from universities in Russia, Ukraine, Central Asia, Caucasus, Europe and North America. In May, UCRS held an international workshop, co-sponsored by the Bank of Sweden Tercentenary Foundation, under the title Protest Baku: Is Azerbaijan Next in Line for a Democratic Revolution? The workshop was 134 (175)
prompted by recent events in the region. Following the so-called color revolutions in other former Soviet republics, many expected Azerbaijan to be the scene of the next popular uprising. Ahead of parliamentary elections in 2005, there were great hopes. Although this early hope vanished, a new wave of mobilization appears to be led by a generation of democracy activists in Azerbaijan strengthened by the growth of social media. Analysts and activists have described them as the beginning of an Azerbaijani Spring, suggesting that what is happening in Azerbaijan may be linked to the Arab Spring. This raises a number of interesting questions and the workshop gave us some interesting answers: what do these protests have in common and can they, despite their diversity, be seen as part of an on-going popular mobilization in Azerbaijan? Why this happening now and what is are the chances of democratic reforms in Azerbaijan? Is it feasible to analyze contention in Azerbaijan from a more general theoretical perspective, or are there specific political, historical or cultural factors that are important in the making and breaking of protest in this particular context? Also in May, UCRS organized an international conference, with generous financial support from the Bank of Sweden Tercentenary Foundation and with funding from the dean of Social Sciences, with participation by scholars from top universities in Russia, Europe and North America. The theme of the conference was What have we learned from the Soviet archives? This question is very important, theoretically and empirically, both for scholars working with archives and for the research community dealing with the area as a whole. Our understanding of the Soviet experience was greatly enhanced by the so called archival revolution in the 1990s. As the Soviet Union disintegrated, a wealth of primary sources previously closed off to research was suddenly made available. Even though access to important sources still remains partial, the revelations made in the last two decades within a number of important areas of research is certainly significant enough to warrant the locution revolution. Access to the archives of the former Soviet Union has been of fundamental importance, providing an opportunity to reassess and reinterpret not only the history of Russia or any other former Soviet republic, but the history of the twentieth century as such. Virtually all fields of the social and humanitarian sciences economics, political science, history, military studies, international relations and literature have been touched by the availability of previously inaccessible sources. The main purpose of the conference was to bring together a group of international specialists in different fields, in order to take stock with two closely related questions: What have we learned from the Soviet archives in the last twenty years? And what potential challenges lay ahead, in terms of access to further primary sources as well as conceptual issues and interpretation? The major published result of the conference activities is a special edition of the Russian Review that will contain four of the papers presented at the conference. In connection to the conference What have we learned from the Soviet archives? UCRS also held an associated workshop under the title Researching the Fate of Raoul Wallenberg and other Unresolved Questions Pertaining to the History of the Cold War Archival Studies and Research Methodology. The workshop was jointly funded by the Swedish Institute and with funds from the dean of Social Sciences. Although more than twenty years have passed since the breakup of the USSR, the fate of the courageous Swedish diplomat Raoul Wallenberg remains unresolved. While the archival findings the officially sanctioned Russian-Swedish Working Group, in operation throughout the 1990 s, clarified several details of Wallenberg s tenure in Soviet captivity, the questions of Stalin s motives for arresting him, as well as his ultimate fate remained unanswered. Recent years have seen very few important findings on Wallenberg in former Soviet archives. Drawing on experiences from research on similar unresolved historical questions of the last century, the workshop was aimed at discussing how to move forward on the Wallenberg-case. It brought together researchers from Austria, Finland, Poland, Russia, Sweden and the United States. Another international conference was held in September under the title Russia's Winter of Discontent: Taking Stock of Changing State-Society Relationships. The winter of 2011-12 was a turbulent time in Russia. Anger over the falsified elections to the State Duma on December 4 brought masses of people into the streets, calling for honest elections and rule of law. Participants were drawn largely from Moscow s youth, creative intelligentsia, and the middle class, and the protests were mainly peaceful. Indignation found a novel and 135 (175)
explosive outlet in the country s rapidly emerging social media. Momentum was kept up through a bitterly cold winter, well into the spring and the May 7 presidential inauguration. For a time it looked like a snow revolution was in the making and that the regime would be compelled to meet the civil society s demands. In reality, the political status quo has been preserved. The regime rolled out a comprehensive program to counter the opposition, and no longer appears willing to enter into dialogue. But Russia is not the same the contours of a vibrant civil society may have emerged, and the transformation of beliefs, values and expectations cannot be undone. Getting the genie back into the bottle will not be possible. The main purpose of the conference was to take stock of what happened, of where we are at present and of what may follow. An interdisciplinary group of distinguished international experts was brought together for two days of sessions to discuss political processes, social movements, prospects for the rule of law, the role of social media and institutional dynamics. A second international conference was held in September; "Contemporary Russian Utopianism: Geopolitics and Identity. This conference examined late-soviet and post-soviet utopian thought in literature, art and politics. It was organized jointly by the School of Languages and Media at Dalarna University, Uppsala University s Centre for Russian and Eurasian Studies, and the Department of Modern Languages at Uppsala University. Contemporary Russian culture is concerned with ideas of government, dictatorship and empire. Since the dissolution of the Soviet Union in 1991, Russian writers have created a bewildering number of futuristic and post-apocalyptic novels which focus on questions dealing with new Russian identity and geopolitics. Russian intellectuals and artists are preoccupied with the same crucial questions, and these questions are highly visible in the public debate. What role do geopolitical narratives and nationalist utopias play in the formation of the Russian political agenda? How does contemporary Russian art represent the ambiguity between national and imperial Russian identity? What role does Russia play in the alter-globalization movement? Which of the concepts associated with Soviet utopian ideas are still developing and nourishing the formation of post-soviet identities? What role does the border concept have in the new geopolitical narratives? The aim of the conference was to explore the range of postmodern Russian utopias, such as neo-soviet utopia, conservative utopia, Eurasian utopia, nationalist and radical Orthodox utopia. In October, UCRS held an international workshop, co-sponsored by the Bank of Sweden Tercentenary Foundation, with the title Love and Sex after Communism: Post-Soviet Intimacies amid Political and Economic Change. The post-soviet countries are societies that shared a uniform Soviet framework of repressed intimacies. With the collapse of the Soviet regime, these intimacies, in some forms but not others, re-emerged into the public sphere. At the same time, religious re-traditionalization, political instability, economic troubles, and commercialization have each affected intimacy in various ways in post-soviet societies. Here, we refer to intimacy as a wide range of practices involving being close, whether emotionally, sexually, or romantically. At the workshop we asked the following questions: Which are the continuities and disjuncture s that link and separate post-soviet sexualities from their Soviet and even pre-soviet roots? How have romance, sexuality, and dating become affected through the rapid rise of luxury consumption culture? How have changing power relationships and inequality throughout society affected understanding and practices of sexuality? In which ways have political, religious, and even technological change released or stymied the 'coming out' of suppressed sexuality practices? How are shifts in the meaning of intimate relationships reflected in language? The workshop brought together researchers working on post-soviet intimacies to discuss the latest findings in this area and provide a peer-review forum to discuss their research. The bulk of papers presented at the workshop will be published in a special issue of the journal Sexuality & Culture in 2014. In November, we returned to the political development in Azerbaijan with an international workshop under the title Post-Electoral Debriefing: Lessons Learned for the Azerbaijani Opposition: The subject was the October 9, 2013 presidential elections that were held in Azerbaijan with Ilham Aliyev winning a landslide victory, in an election that the OSCE/ODHIR monitoring mission described as seriously flawed. Still the election illustrated interesting new currents in Azerbaijan s political life. The National Council of Democratic Forces in Azerbaijan appeared on the scene as an election coalition uniting traditional opposition parties, academics, 136 (175)
representatives of civil society, youth activists as well as religious organizations. The fact that they promoted one joint opposition candidate was applauded and this merging of old and new opposition figures generates a dynamic largely absent during previous elections and in Azerbaijani politics at large. At the workshop, a range of regional and theoretical experts discussed these new dynamics and issues like if and how the new opposition influenced the electoral process and the impact of social media. The workshop also catered tothe topic of opposition and democratization on a more general level, making it applicable to other contexts as well. It was co-sponsored by the Bank of Sweden Tercentenary Foundation and by the Uppsala Forum for Peace and Democracy. The last international conference of the year was devoted to one of our other profile areas, the Baltic region. The conference was organized in collaboration with Centre for Russian, Central and East European Studies (CRCEES) at Glasgow University. The title of the conference was Latvia A Work in Progress? 100 Years of State and Nation-building. " A quarter century after the formation of the Popular Front, and a decade since joining the EU, processes of state- and nation-building in Latvia are still ongoing. Issues such as citizenship, language policy, minority rights, democratic legitimacy, economic stability and security all remain the objects of vigorous public discussion. The current situation in turn reflects longer-standing debates over the course of the past century concerning the relationship between state, nation and sovereignty in the context of Latvian society and polity. By examining different aspects of this relationship, the conference revealed key turning points as well as continuities in its development and thereby helps to inform current debates. The conference brought together researchers from Sweden, Europe and the United States. The Centre is finally also participating actively in a university-wide ambition to organize area-focused research among the departments at the disciplinary domain of humanities and social sciences. Currently there are seven area-forums at the university, dealing with regions such as Russia, Africa, China, Latin America, North America, South Asia and Germany. As a result of this cooperation, a well-attended public event was organized in November at the Museum Gustavianum in Uppsala, under the title Identiteter i en globaliserad värld (Identities in a globalized world). Apart from conferences, workshops and public events, another major activity during 2013 was to maintain a high level of excellence at our weekly seminars and in our guest researcher program. Over the year, the Centre held some thirty research seminars with high attendance and accommodated thirteen guest researchers who stayed at the Centre for periods of two weeks up to several months. Workshops outside UCRS were held in Kiev May and October, within the framework of a book project on textbooks and perestroika with researchers from Moldova, Russia, Ukraine, Belarus and Sweden (Sergiy Kurbatov and Li Bennich-Björkman). We entertain the idea to launch a Perspectives on Elections roundtable series figuring individual countries and using the competence of present or affiliated UCRS researchers to fulfil a need for the interested public to learn more on individual countries. For example, we will start this semester with Ukraine and then establish a schedule were we make these roundtables in some kind of recurring sequence. Please describe the major results within the environment in 2013. (Question Q3) We are pleased to note that UCRS is well under way towards gaining international recognition as a wellrespected centre for the pursuit of research on post-soviet transformation, holding its own amongst other established Centre s for such research. Activities during the year, ranging from conferences and workshops, to visiting scholars of international distinction and achievement by resident scholars in terms of publications in leading journals and presentation of ongoing research at international conferences and workshops, have been strongly conducive toward achieving this goal. The strong multi-disciplinary nature of the research, the strong content of international exchange, a lively program of visiting scholars in residence and an ambitious seminar program have all contributed towards creating an open and innovative research milieu where a variety of new 137 (175)
theoretical and methodological approaches is being developed at the research frontier, aiming to understand the meaning and implications of contemporary political, economic, societal and cultural developments in the geographic areas in focus. A major result for 2013 has also been the confirmation of a well-functioning organization and administration. Previous work to foster collaboration and visibility of the Centre at the disciplinary domain of Humanities and Social Sciences has been fruitful. The Centre is now progressively seen as an important complement and partner to the other departments in both research and teaching. The UCRS visiting fellows program has developed according to plan. Over the year, the Centre has hosted visiting researchers from the United States, Australia, Russia, Ukraine, Germany, Belarus, Finland and the United Kingdom. One PhD-student at the Centre successfully defended her dissertation: Harmonizing National Laws on Trafficking by Implementing Article 3 of the Palermo Protocol: Problems and Reform." After the defense of her PhD- dissertation, she proceeded to win a two-year grant from the Swedish Crime Victim Compensation and Support Authority (Brottsoffermyndigheten) to continue work on human trafficking. She had one article accepted for publication in a peer reviewed journal in 2014, and submitted one article to another peer reviewed journal. Also, a successful MPhil defense EU enlargement into the Western Balkans took place during the year. One researcher has received a major long-term research grant from the Swedish Research Council and several others shorter-term research grants, travel grants and substantial conference grants. Research director Elena Namli has been appointed international expert on the Russian Research Council Committee (Российский гуманитарный научный фонд РГНФ). Our ambition to promote international collaboration and cooperation has been rewarding and has resulted in intensified contacts with not the least British universities (Glasgow, Birmingham, Bristol, Warwick). This has been facilitated by our visiting fellows David Smith and Nino Kemoklidze. During 2013, we had several visiting fellows from these environments (Paul Jordan, Maria Koinova, Stephen Wolff, Marina Germane) and this work continues. Over the year we have also strengthened our cooperation with the Russian Academy of Sciences and six universities in the Russian Federation. Recent publications based on projects completed by visiting Russian scholars while at the Centre include two monographs Vladimir Malachov s Культурные различия и политические границы в эпоху глобальных миграций" and Boris Mezjuevs «Опыт повторения». 138 (175)
16. Strategiskt forskningsområde: Produktionsteknik Huvudansvarig myndighet: Samrådande myndighet: Vinnova Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 25 35 50 50 50 Avsättning till infrastruktur 1 1 2 2 2 Budget efter avsättning 24 34 48 48 48 16.1 Sustainable Production Initiative Huvudsökande: Chalmers Tekniska Högskola 83% Medsökande: Lunds universitet 17 % a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 29 168 000 Personell 18 936 000 Co funding from main applicant higher education institution 14 584 000 Running costs 4 449 000 Co-funding from-co-applicant higher education institution 3 420 000 High cost Equipment 1 920 000 Funding from collaborating research institutes Infrastructure running costs Funding from other collaborators Other costs 7 588 000 Other external funding Totalt: 32 893 000 Totalt: 47 172 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. Co-fundings from co-applicant within the production science area is Lund University 3 420 000 kr. Chalmers has chosen not to report the amount of external funding above because of the difficulty to produce figures that accurately reflect the funding situation in the strategic research area (SRA). This has several reasons, for example: (i) a fairly large portion of the researchers are involved in more than one AoA and their external grants might partly or entirely be used for projects in other areas, making it difficult to determine to what extent the external funding should be attributed to one or the other area, (ii) some researchers are involved in research within the area, but not directly associated with the AoA, and therefore do not report their results or external funding here. Also, (iii) external funding received by researchers involved in the area at our partner universities is difficult to determine and to include in a relevant way. 139 (175)
During 2013, Chalmers has investigated and considered several different models for reporting external funding to these environments, both by internal analysis and by conferring with some of the other involved Swedish universities. We have recently decided on a model for reporting external funding in a satisfactory and authentic way and will use this for reporting for the entire period of 2010-2013 during the self-evaluation in spring of 2014. Please state the main priorities within the environment in 2013. (Question Q1) The Sustainable Production Initiative (SPI) is the major production engineering research environment in Sweden. It is focused on sustainable and competitive production. During 2013 the main research, innovation, and education priorities of the strategic environment were to: Development, establishment, and implementation of the previously defined sets of measurable and industrially applicable sustainability parameters (economical, ecological, and social) To increase the number of peer-reviewed journal publications To establish an international research environment at Chalmers by increasing the number of internationally recruited personnel To increase the environment's impact on all educational levels through increased sustainability content in courses and increased sustainability student awareness To influence roadmaps and calls for proposals to increase our chances for funding through increased involvement of the environment's researchers in planning and roadmapping for future European and national research programmes To increase the use of the National Production Innovation Laboratories at Chalmers and in Lund Please describe the major activities within the environment in 2013. (Question Q2) Throughout 2013, activities aimed at measuring and increasing sustainability awareness were performed by the SPI Sustainability Group. Workshops, individual concept mapping, interviews, and documentation were some of the instruments for these efforts. In Q1 and Q2 a strong effort was made by parts of the SPI management group to support development of an application for a national strategic research and innovation programme. The application was submitted and succesfully evaluated, resulting in the launch of a national SIO (strategiskt innovationsområde) programme, called Produktion2030 in Q4. Produktion2030, the SPI environment, and the XPRES environment (KTH/MDH) form complementary resources in a coordinated effort to strengthen production related research and innovation in Sweden. The SPI environment is also involved in the SIO programme Lighter. In Q2 2013 the environment was evaluated by our international advisory committee (Professors Gunther Seliger, Jack Hu, and Reijo Toukko) in order to increase the environment s precision and performance. The advisory committee spent several days interviewing and assessing the environment, preparing advice for the SPI management group. In Q3 our research infrastructure for innovation, collaboration, and joint industry/academia efforts was further developed when the Manufacturing Process Laboratory at Chalmers, was inaugurated. During 2013 the Production Gateway at Lund university was established to promote both interdisciplinary and industry collaboration within the area of production. The new competence centre ProMatEn was also established during 2013 with a special purpose of supporting national and regional industrial partners in collaborating with the European research facilities ESS and Max IV. In connection to these two new establishments the new joint laboratory facility Production Gateway Laboratory was inaugurated in May 2013. 140 (175)
Please describe the major results within the environment in 2013. (Question Q3) In 2013 the SPI environment was assessed and compared to international standards by our international advisory group. The advisory group concluded that SPI constitutes an internationally unique environment. They could see no other environment, globally, that has implemented Sustainable Production knowledge so deeply into all aspects of research, education, and industrial/societal collaboration. The environment is internationally attractive, as shown by international collaboration, number of guest researchers, and international research proposals indicate a high international standing for the SPI. Industrial collaboration is high and preferred partnerships and competence centres with e.g. AB Volvo, ABB, Volvo Car Corporation, SKF, and SAAB Aeronautics have been deepened through corporate management level agreements. The amount of industrial training is maintained on a high level. The environment has also become partner in an increasing number of successful European projects, indicating the standard and strength of the SPI. The national production innovation lab infrastructure has been further strengthened by the renovation and inauguration of the manufacturing process laboratory. The total suite of labs now constitute a complete product and production development infrastructure, that can be used in research projects, demonstrations, teaching, and industrial collaboration. During 2013 the Production Gateway Laboratory at Lund University was strengthened with new equipment for nano indentation and 3D geometry analysis at nano/micro level. During 2013, the SPI environment has been influential in the development of relevant national and international research programmes. SPI has contributed to the Horizon 2020 preparation of the European (Public-Private-partnership) organisation EFFRA (European Factories of the Future Research Organisation) (http://www.effra.eu/). Nationally, the SPI management group has participated in the development of the new national research and innovation (SIO) programme, Produktion2030 (www.produktion2030.se). Several scientific breakthroughs are described in other sections within this document and linked documents. 141 (175)
16.2 XPRESS Initiative for excellence in production research Huvudsökande: Kungliga Tekniska Högskolan 75% Medsökande: Mälardalens Högskola 25% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 19 000 000 Personell 7 467 000 27 782 000 Running costs 4 102 000 Co-funding from-co-applicant higher education institution 4 175 000 High cost Equipment 2 793 000 Funding from collaborating research institutes - Infrastructure running costs 1 691 000 Funding from other collaborators - Other costs 3 549 000 Other external funding 114 700 000 Totalt: 19 602 000 Totalt: 165 657 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. Source Sum Tkr Funding from public agencies 66 873 Public research foundations 6 922 EU 25 564 Other international funding - Private non-profit organizations 5 098 Private companies 8 025 Other 2 218 Grand total 114 700 Please state the main priorities within the environment in 2013. (Question Q1) The Initiative for excellence in production research XPRES is established to develop cutting-edge research and education environment within advanced production. The main priorities of the initiative in 2013 were: 1) To continue strengthening the internal XPRES research environment by activities leading to interdisciplinary cutting-edge research in national and international projects including collaborations with external academic/industrial partners. To support cross-divisional, collaborative innovation within industry and to integrate the competences within the three focus areas into one common demonstrator following the XPRES vision has been assigned very high priority. 142 (175)
2) To transfer research findings to education both at national level (undergraduate and graduate courses) and European level (co-organized workshops and development of course modules and the Initiative on European Learning Factories) to ensure re-growth in terms of young talented researchers. 3) To continue developing and upgrading the infrastructure in XPRES virtual lab, connected to international virtual environments, and XPRES real lab on KTH campus is still of high priority. 4) To bring the XPRES focus areas to surpass similar global/national efforts. For example, that focus area groups of XPRES collaborate with international research groups working in parallel. 5) Establishing a cooperation center for heavy powertrain manufacturing hosted by KTH under the umbrella of German and Swedish research institute organizations. The primary Swedish industrial stakeholders are Scania, Volvo and Sandvik. 6) To materialize the strategic industrial partnerships (Scania, Sandvik, Saab, ABB and Volvo) by specifying concrete action plans. 7) To contribute to formulating the strategic innovation agenda (SIA) for Swedish production, "MADE IN SWEDEN 2030" and SIA LIGHTer in lightweight. Also to quickly propose and initiate new strategic innovation area (SIO) projects. Please describe the major activities within the environment in 2013. (Question Q2) Following the main priorities, the major activities 2013 are described below: 1) To integrate the XPRES focus areas, development of a common demonstrator that combines the XPRES competencies concerning new materials, product and process technologies, new business models and digital engineering has been initiated. It will cover all activities in the product realization process with the goals that a) customized products are produced with the same efficiency as in mass production, b) new technologies are easily introduced and industrialized and c) production is sustainable in terms of ecology, sustainability as well as economy. 2) The course Digital factories at KTH includes 3D modeling and is continuously updated with research findings and infrastructure developed in XPRES lab. Results from student projects will be implemented in future courses in 3D modeling both at KTH and MDH. The undergraduate education programs at KTH and MDH has during 2013 had an increasing level of interaction on teacher and student level. The Network of Innovative Learning- Factories NIL, with KTH in the consortium is currently working on producing a learning factory video. XPRES is preparing for hosting the 4th Conference on learning factories in May next year. All three XPRES-related engineering programs at MDH are under a major revision during 2013/2014 and will be even closer linked to the XPRES focus. In specific courses the XPRES research and innovation focus has been stronger interlinked. 3) Procurements of a waterjet machine for 3D milling, industrial robots for human-robot collaboration and equipment for additive manufacturing (3d printing) of metal products are underway. 4) One strategically important prioritized liaison is with Fraunhofer IWU in Chemnitz for advanced manufacturing of automotive components. XPRES researchers have taken advantage of research results from the German colleagues and the infrastructure at IWU to extend the applicability of the gear rolling process to gears with larger modules for heavy vehicle transmissions. 5) Discussion on establishment of a formal collaboration in terms of a cooperation center for heavy powertrain manufacturing, hosted by KTH, has been initiated by face-to-face meetings with institute and industrial top 143 (175)
management for establishing a common platform. The push and support from XPRES industrial partners prove that this would be a most desirable future development. 6) Executive group meetings, research seminars, workshops and short term mobility for students and researcher mobility have been held during 2013, all aiming at leading to relevant research activities. 7) XPRES has played a key role along with Teknikföretagen as coordinator in formulating the SIAs. An interesting multi-diciplinary development is the new research activities in the area of resource-efficient healthcare. The basic idea is to use industrial knowledge, methods and practices for resource management and patient flows to meet the needs, preferences and capabilities of the patient of tomorrow along with an efficient use of resources. Please describe the major results within the environment in 2013. (Question Q3) The results described are attributable to XPRES' long-term strategy, not directly to the priorities of and initiatives taken 2013. In total, 15 national projects, 2 projects for researcher mobility and 3 EU FP7 projects were accepted in 2013. Among the national projects, 3 production and 2 LIGHTer SIO projects coordinated by XPRES are already started or ready to start in 2014. Innovative manufacturing processes have been developed: 1) Hybrid joining of aluminum alloys to different thermoplastic materials including composites. 2) Gear rolling for large gear wheels in a virtual environment. 3) Robotized forming of pre-stacked composite laminates. 4). Hole reinforcement for composite materials. 5) Selfreinforced composites. 6) Processability of nano-fibre reinforced aerospace composite materials. Novel performance assessment schemes and structures have been developed: 1) A location decision process and criteria for global production. 2) Integrated management systems for operational efficiency and environmental management (lean and green management). 3) Structure and enablers for managing change in performance measures within a manufacturing context. 4) Methods for radical improvements (Kaikaku), complementing continuous improvement (Kaizen) in production toward creating unique production systems. 5) The work on ISO 20140 for evaluating energy efficiency and other factors in manufacturing that influence the environment continued. For human-robot collaboration, a system has been built to provide the ability for the operator to perform remote assembly operations using an industrial robot. A simulation module has been developed to minimize the energy consumption of the industrial robot movements. XPRES authors achieved the Outstanding Journal Paper Award 2013 by Emerald Press for writing about the IDEAS results. XPRES and their partners are amongst the first, globally, to prove that distributed multi-agent system applications are viable for industrial applications and that plug & produce systems are now potentially feasible. This technology is currently being transferred to Senseair AB in Sweden through a VINNOVA project. The ultra precision coordinate measuring machine, developed at Micronic-Mydata, has been presented in a doctoral dissertation at KTH. It is by far the most advanced large area measurement system ever built and its performance with nm-accuracy over square meters is surpassing all systems available in the national metrology labs worldwide. Thanks to this system the production quality of all LCD and OLED screens is assured and we can enjoy the quality of the new 4K displays delivered by Samsung, LG and Sharp in the future. 144 (175)
17. Strategiskt forskningsområde: Stamceller och regenerativ medicin Huvudansvarig myndighet: Vetenskapsrådet Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 25 35 65 65 65 Avsättning till infrastruktur 2 4 6 6 6 Budget efter avsättning 23 31 59 59 59 17.1 Center for Regenerativ Medicine Huvudsökande: Karolinska Institutet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 30 344 000 Personell 5 978 000 Co funding from main applicant higher education institution 18 599 000 Running costs 7 623 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 251 000 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 1 770 000 Other costs 3 792 000 Other external funding 25 870 000 Totalt: 17 644 000 Totalt: 76 583 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. For this SFO we have chosen a model to present co-financing by including all or part of other strategic initiative that are directly linked to the SFO program. Thus support from two Linne center financed by VR (15870 tkr), part of a center WIRM financed by KAW (7000 tkr) and part of a KI-AZ collaboration (3000 tkr). Support from KI, include one thematic center financed by KI (5060 tkr), approx 30% of support to corefacilities KCTT and Zerbrafish (1770 tkr), and all direct support from KI to PI in the program distinguished professor award, KID-PhD support or other strategic support is also included (in total 11199 tkr). SLL contributes to VECURA (1695). 145 (175)
Please state the main priorities within the environment in 2013. (Question Q1) The overarching priority for the Strategic Research Initiative in Stem Cell Research and Regenerative Medicine at Karolinska Institutet (StratRegen) is to advance the field of regenerative medicine to long-term develop therapies to diseases which currently cannot be cured, and where new therapies and treatments are acutely needed. Examples of such diseases are the neurodegenerative disease Parkinson's disease, diabetes, heart and liver diseases, and injuries to the brain and the spinal cord. The current lack of real treatment for these diseases causes not only death and suffering among the patients, but is also a huge financial burden for the society. The prospect of using new cells to repair a damaged or diseased tissue would radically improve the current situation, and we work on several strategies to realize this goal. Karolinska Institutet is the largest medical university in Europe, and is therefore uniquely positioned to take on an internationally leading role in stem cell research and regenerative medicine. Karolinska Institutet prioritizes stem cell research and regenerative medicine in its long-term research strategy and is already at the international forefront in many areas of these two fields of research. The funding provided from StratRegen has had a unique impact in realizing several objectives that otherwise would have been impossible to accomplish. During the last few years, including 2013, recruitments of leading international scientists in important research areas have been carried out, and from these recruitments we now begin to see world-leading new approaches to bring new ideas and concepts into the clinic, for the benefit of patients. During 2013, Professor Ken Chien has relocated his laboratory from Harvard Medical School in Boston to Karolinska Institutet, and already introduced novel approaches to cure heart disease. During 2013 we have also seen several examples where infrastructure established in StratRegen has become vital for collaboration with industry. Importantly, a large research agreement has been closed between Karolinska Institutet and AstraZeneca, which is critical to maintain and further develop the pharmaceutical industry in Sweden. In StratRegen, we continue to foster the next generation of science leaders in regenerative medicine, and these junior scientists have been very successful in competing for internationally financed funding and positions Finally, we believe that by bringing the best scientists together and creating an environment where they can collaborate and have access to the most modern research equipment and infrastructure, Karolinska Institutet will further develop its position as a world-leading research institute in this area, and bring new therapies for diseases to patients as well as contributing to a knowledge-based economy and society by new discoveries and methods. Please describe the major activities within the environment in 2013. (Question Q2) During 2013, Professor Ken Chien has started his research activities at Karolinska Institutet and has relocated his laboratory from Harvard. Professor Chien has during 2013 continued to publish groundbreaking work, in particular in the area of novel ways of controlling gene expression in the heart. These new technologies have been rapidly established at Karolinska Institutet, and importantly have also led to novel industrial activities in the biotechnology area. An US-based company, Moderna Therapeutics, closed a major deal with AstraZeneca and is now in the process of establishing a Swedish subsidiary, Moderna Sweden, which will be located at Karolinska Institutet. Furthermore, Professor Chien s research has been a key factor contributing to a new research agreement between AstraZeneca and Karolinska Institutet, where a joint research center with a 5- year budget of 650 MSEK will be located at Karolinska Institutet. This activity is a very important factor in enhancing the links between the pharmaceutical industry and academic research in Sweden, and long-term critical to counteract the negative trend Sweden-based pharmaceutical industry that has been observed during a number of years, and exemplified by the closing down of AstraZeneca centers in Lund and Södertälje. StratRegen also reports a continued development during 2013 in the translational and clinical area. As mentioned above, new strategies to improve cell-based transplantation for liver disease has been implemented 146 (175)
by Professor Stephen Strom, and successful follow-up studies of transplanting the first biosynthetic organs, the airways (trachea), have been reported by Professor Paolo Macchiarini. Please describe the major results within the environment in 2013. (Question Q3) StratRegen continues to publish novel research data in the leading international scientific journals. For example, Ernest Arenas research group provides new insights into how stem cells mature towards dopaminergic neurons, the cell type that degenerates in Parkinson s disease. In other areas of nervous system research, Jonas Frisén and co-workers have provided new data on how one brain region responsible for memory formation, hippocampus, undergoes renewal in the brain. The same research group has also clarified the role of neural stem cells in response to injury to the spinal cord, a medical condition where we currently lack therapies. In another important research area, the blood system, considerable progress has also been made. Sten Eirik Jacobsen s and Rickard Sandberg s research groups have collaborated to provide fundamental new insights into how the immune system is shaped. They demonstrate a new, early stem cell that is responsible for the generation of for example antibody-producing cells. This information is highly relevant both to better understand the origin of our immune system and to further advance for example bone marrow transfer treatment in patients. With regard to heart research, Ken Chien s research group has taken an important step in understanding how the heart forms during development, as they have discovered a novel way to identify the cells that make up one part of the heart (the so-called primary heart field). Furthermore, they have developed a completely new technology to control how specific genes are expressed in vivo. This is a technological breakthrough which forms the basis for collaborations with AstraZeneca and the development of new industrial activities in the biotechnology sector in Sweden (see above). Rickard Sandberg and Sten Linnarsson are at the fore-front of technology development in the area of gene expression analysis, and have developed novel methods to measure which genes are active in a single cells. This technology development is important for research across many different disciplines, and is also of high importance for the national Science for Life Laboratory 147 (175)
17.2 National initiative on Stem Cells for Regenerativ Therapy Huvudsökande: Lunds universitet 80% Medsökande: Uppsala universitet 20% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 29 166 000 Personell 15 967 405 22 578 479 Running costs 5 131 705 Co-funding from-co-applicant higher education institution 7 284 791 High cost Equipment 6 207 084 Funding from collaborating research institutes Infrastructure running costs 416 721 Funding from other collaborators Other costs 4 149 588 Other external funding 62 710 023 Totalt: 31 872 503 Totalt: 121 739 293 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. VR 34% EU 22% Cancer foundation 13% Children's foundation 8% Other foundations 23% Please state the main priorities within the environment in 2013. (Question Q1) The overall objective of StemTherapy is to advance the development of stem cell-based cell replacement therapies for diabetes, stroke and hematological diseases and to build a strong base of knowledge about stem cells and disease mechanisms to pave the way for future efforts to devise new therapies. StemTherapy addresses this by assembling very strong competence in basic stem cell biology and clinical cell therapy. By using an overall strategy where interdisciplinary research teams address research questions common to the clinical translational programs it is highly likely that progress in one disease area will catalyze progress in the other disease areas. Furthermore, to renew the research, technical possibilities and educational efforts StemTherapy has established extensive collaborative ties with national and international institutions to increase diversity, quality and innovation. During 2013 StemTherapy has put particular focus on the following: 148 (175)
Based on recommendations from the scientific advisory board, StemTherapy distributed significant resources as: (i) clinical project grants for projects aiming at clinically implementing new stem cell therapies, (ii) collaborative project grants to enhance interactions between different disease areas within the program, and (iii) support grants for PhD students to foster education of new scientists in the field. The grant applications were reviewed by national and international external experts. During 2013, StemTherapy has made several strategic recruitments from USA and Great Britain at the junior faculty level. These recruitments have been made following broad announcements and members from the scientific advisory board have assisted in reviewing the candidates. These new scientists have outstanding track-records and will greatly enhance the environment. StemTherapy has further allocated substantial resources to establish new - Fluidigm platform - single-cell genomics based on microfluidic technology. We have purchased and installed the equipment and employed Research Engineer for service and educational purpose. In addition, StemTherapy has continued to strengthen and further develop the already established state-of-the-art technical platforms. The establishment and coordinated use of fore-front technology will be instrumental for making major advances in our rapidly developing field. StemTherapy continued support both pre- and postgraduate education and research training within the stem cell field. To support and facilitate the interactions between the clinic and basic research. Please describe the major activities within the environment in 2013. (Question Q2) In addition to directly supporting the research activities of the program, StemTherapy has continued to support interactions between clinical and basic research, education and training at multiple levels, national and international collaborations, as well as the dissemination of results and outreach to the general public. In September 5-6, 2013, Stem Cell Center/StemTherapy held a two-day retreat at ÅhusStrand for all scientists and students involved in the program. The meeting promoted highly engaging scientific discussions and provided valuable input for the program and its future priorities. In May 2013, StemTherapy hosted the scientific advisory board (SAB) composed of world leading experts in the area for a two day meeting. The meeting promoted highly engaging scientific discussions and provided valuable input for the program and its future priorities. The SAB members have met not only PIs but also young group leaders, postdocs and PhD students. The SAB wrote an extensive summary and recommendations which will be used by StemTherapy for strategic decisions and further development of the program. During 2013 StemTherapy has hosted numerous seminars with top-level international speakers. Moreover, StemTherapy has hosted several mini-symposia with world-leading experts on topics relevant for the goals of the program. The research school in stem cell biology (RSCCB) has provided advanced training in stem cell research at the graduate, postgraduate and postdoctoral levels through lectures, hands-on courses and career development programs. StemTherapy scientists have been invited speakers at numerous conferences and meetings around the world and several novel research findings have been recognized in the media. StemTherapy scientists have further been engaged in activities to spread information about stem cells and regenerative medicine to the general public and schools. 149 (175)
Please describe the major results within the environment in 2013. (Question Q3) Studies carried out by the scientists at StemTherapy in 2013 brought us closer to the development of stem cell based therapies for diabetes, stroke and hematological diseases. The work has resulted in many publications in high impact journals. In addition, StemTherapy scientists have obtained a number of prestigious national and international grants in tough competition and have secured significant external funds. For diabetes, significant further progress has been made in the research on developing beta-cells in vitro. We have successfully generated targeted human embryonic stem cell lines to monitor the efficiency of differentiation protocols. A primary cell culture system for reprogramming somatic cells into insulin producing cells has been established. We have also optimized the viral delivery system which allows efficient infection with up to 10 different viruses simultaneously. We have for the first time identified novel cell surface markers for isolation of human embryonic stem cell (hesc)-derived beta cell progenitors and discovered that intracellular tension controls beta cell differentiation. These results were obtained in mice and we are currently attempting to translate these observations to hescs with the aim to better control differentiation of hescs into glucose-responsive beta cells. A new concept to immune-isolate insulin producing islet cells from host immune cells using a chamber model has been developed. This chamber is unique by providing direct blood contact to the semipermeable membrane that separates host blood (not tissue) and islet cells. This allows direct diffusion of oxygen, nutrients and glucose into the chamber and insulin transport from the chamber to blood. Further development of a microencapsulation technique based on polymerization of cell membrane-bound PEG coat has been done. The technique allows encapsulation of cells and cell clusters with an extremely thin semi-permeable membrane with a functional poor size between 150.000 and 500.000 kda. This membrane is aimed at allogeneic immunoisolation of cells, but modifications of the polymerization can potentially also protect against xenogeneic attack. We have also developed novel methods to deliver therapeutic nucleic acids to cells without using any transfection reagents. This breakthrough achievement is a new paradigm in the field of nucleic acids therapeutics and opens enormous possibility to find effective treatment options for diseases that were not possible before. We have carried out several studies showing the possibilities for stem cells derived from different sources to counteract stroke-induced functional impairments. We demonstrated in rat and mouse model of stroke that human induce pluripotent stem cell-derived neuroepithelial-like stem cells can be efficiently fated to generate neurons with cortical phenotype and when transplanted in stroke-damaged rodent brain interact with the immune system, integrate into host tissue and improve functional recovery. New genes, pathways and intrinsic factors have been identified that are involved in the regulation of blood stem cells. Moreover, aged stem/progenitor cells can be reversed to a functionally young state by somatic cell reprogramming, with little evidence for a memory of the aging state. Clinical studies headed by Johan Richter (gene therapy for infantile malignant osteopetrosis) and Stefan Scheding (isolation and transplantations of primary MSCs to promote stromal repair and recovery) and supported by StemTherapy have been continued during 2013. Sex related differences in ips cell lines have been identified based on RNA expression analysis performed on 20 newly generated ips lines from two neonatal starting source cells of male and female donors. The phenomenon of x reactivation of female ips lines can have unexpected consequences for the differentiation potential of the lines. 150 (175)
18. Strategiskt forskningsområde: Säkerhet och krisberedskap Huvudansvarig myndighet: Vinnova Samrådande myndighet: Vetenskapsrådet År 2010 2011 2012 2013 2014 Total budget 5 15 20 20 20 Avsättning till infrastruktur 0 1 1 1 1 Budget efter avsättning 5 14 19 19 19 18.1 Security Link Huvudsökande: Linköpings universitet 87% Medsökande: Kungliga Tekniska Högskolan 10%, Chalmers Tekniska Högskola 3% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 7 600 000 Personell 5 170 088 Co funding from main applicant higher education institution 2 044 412 Running costs 605 810 Co-funding from-co-applicant higher education institution 1 737 623 High cost Equipment Funding from collaborating research institutes 500 000 Infrastructure running costs 6 179 Funding from other collaborators Other costs 1 817 905 Other external funding 59 944 070 Totalt: 7 599 982 Totalt: 71 826 105 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. Funding from public agencies 16 106 540 Public research foundations 1 710 195 EU-framework programmes 40 278 332 Other international funding 435 116 Private non-profit organisations 48 507 Private companies 1 365 380 Please state the main priorities within the environment in 2013. (Question Q1) The main strategic priorities during 2013 have been: revision of the national research and innovation agenda within the security area, which was published in May 2013; to expand the funding by providing pro-active support for individuals or teams to apply to open calls; to incorporate the cross-disciplinary graduate school 151 (175)
Forum Securitatis into the Security Link organization; to increase the number of adjunct positions; to, in cooperation with industry, organize and submit a proposal to VINNOVA on a Strategic Innovation Programme Security; to incorporate the Security Link workshop TAMSEC into the biannual Swedish meeting place Samhällssäkerhetsmässan, a joint venture that took place in November 2013; to enlarge the international network; and as a result, participate in a pilot project against poaching in Kenya. Some of the research priorities during 2013 cover: target tracking in very complex scenarios with a lot of sensor data and targets; tracking of humans with synthetic aperture radar; Advanced sensors and detectors in areas such as THz region to detect objects concealed behind clothes etc., explosives detection, maritime surveillance, critical infrastructure protection, drinking water monitoring (CB sensing); retrospective dosimetry and UAS gamma spectrometry (RN sensing); multisensor positioning concepts for first responders; MIMO for increased robustness in TETRA-systems; Research for an early-warning service for emerging communication problems in security & safety applications; Interference detection and countermeasures for GPS-receivers; Large MIMOsystems for increased robustness and/or capacity; Advanced sensors and detectors in areas such as THz region to detect objects concealed behind clothes etc., explosives detection, maritime surveillance, critical infrastructure protection, drinking water monitoring (CB sensing); retrospective dosimetry and UAS gamma spectrometry (RN sensing); The decision support and response area focuses on semantic complex-event processing and other related semantic technologies for data analysis, especially analysis a large volumes of real-time streaming data; Methods to analyze cyber domain incidents are also studied. Furthermore, the area addresses simulation, especially simulation of pandemic outbreaks of infectious diseases. KMC has focused on expanding research into military medicine and medical triage. At KTH, priorities has been on philosophical analysis of the core concepts of the field. Please describe the major activities within the environment in 2013. (Question Q2) In particular efforts have been devoted to: Regular steering group meetings, reference group meetings of end users and industry in order to further develop the environment; implement changes based on the mid-term evaluation 2012 with an international review panel; coordinating of a Strategic Research and Innovation Agenda and a Strategic Internationalization project within VINNOVA programs; the workshop TAMSEC, which was part of Säkerhetsmässan in Kista 2013; efforts to stimulate individuals to apply for joint positions, SFO funded projects (FOI) and apply for the graduate school (PhD students); Continuation and increased activities in projects initiated through a process at FOI where collaboration with other groups are required in order to improve the collaboration within the environment; Continued activities with information and brainstorming around each new call for proposals has been performed, divided into different subject areas, and active headhunting of people that the SFO judges are well suited for each call. Some of the research activities during 2013 are: several papers on tracking of wheeled and airborne vehicles using microphone networks, using data from the Security Link field trial in Lilla Gåra 2012; increased robustness of wireless communications for security & safety applications; measurement in a tunnel system to determine the radio channel properties for GPS-denied environments for application on indoor-positioning of e.g. emergency personnel during operations; development of a new method for semantic complex-event processing based on both ontologies and semantic-web technologies as well as engines for complex-event processing; development of new modeling approaches for disease transmission at workplaces as well as explored new approaches to efficient simulation run-time performance for the pandemic-simulation area; research projects in areas of e.g. new actors, collaboration and IT support in emergency response. In the sensor area, projects are focused towards THz sensing, compressed sensing systems, positioning of fire fighters in rescue operations, SLAM & ATR, drinking water monitoring, retrospective dosimetry and UAS gamma spectrometry. We participate in the VINNOVA UDI "Online sensor systems for resource-efficient water management (Sensation) project with 23 partners. In the area of Security of explosives the new EU project SUBCOP, coordinated from FOI, is focusing on new methods to prevent suicide attacks. KMC has formed a research group in military command and control together with Borås University with joint supervision of two 152 (175)
PhD students. Activities and tasks aiming for a structured and useful definition of security and related concepts. Please describe the major results within the environment in 2013. (Question Q3) Some of the results for the environment during 2013 were the following: TAMSEC (the yearly symposium within Security Link) was integrated with 'Samhällssäkerhetsmässan'. This is decided to be a bi-annual event, and the number of participants was around 1500. This combined research workshop and fair is expected to boost the interest from researchers and providing the national meeting place we have aimed for from the start; Final reports prepared for Strategic Internationalization and published for the Strategic Research and Innovation Agenda; passed the first stage with a proposal to establish a Strategic Innovation Area within Security in a VINNOVA call; The graduate school Forum Securitatis constitutes one important part in the environment and has now been fully integrated with Security Link; The spin-off company Senionlab have employed 3 Security Link researcher full time, and several projects with main actors in the Security domain were initiated; The area on sensor fusion was awarded a Marie Curie grant worth 3 PhD students and one postdoc for projects on tracking in complex systems, a core problem in surveillance applications. Some of the highlights among the scientific results are the following: Key results of an early-warning service for emerging communication problems in security and safety applications; Results about jamming detection in GNSS receivers were published at the international conference ION GNSS, Nashville USA; A portable system, based on commercially available low-cost products, for continuous monitoring of radio interference in the GPSfrequency band was developed and successfully tested in a real environment at a critical infrastructure; Results on amplifier-aware multiple-input multiple-output power allocation; new technique to measure low concentrations of dissolved substances in raw water suitable for continuous on-line monitoring, the possibility to file a patent on the technique is investigated; unmanned aerial system (UAS) for detection of radiological threats has been built and tested; demonstration of the use the touchscreen of smart phones for retrospective dosimetry using EPR; camera systems have been developed and tested for positioning and localization of fire fighters; two stereo vision systems based on cameras operating in the visual and thermal wavelengths, respectively, have been developed and tested in smoke diving applications; For the pandemic simulation, the new workplace model will be an important basis for further simulation experiments; Initial philosophical characterization of the concept of information security. 153 (175)
18.2 Natural-Disaster Science Huvudsökande: Uppsala universitet 64,4% Medsökande: Karlstads universitet 17,8%, Försvarshögskolan 17,8% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 11 465 000 Personell 11 195 519 4 284 695 Running costs 762 962 Co-funding from-co-applicant higher education institution 1 775 019 High cost Equipment - Funding from collaborating research institutes 809 668 Infrastructure running costs 260 741 Funding from other collaborators 4 064 545 Other costs 614 801 Other external funding 119 075 Totalt: 12 834 023 Totalt: 22 518 002 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. All "Other external funding" comes from the Beijer Institute of Ecological Economics. Please state the main priorities within the environment in 2013. (Question Q1) In 2013, the Centre s priorities changed slightly as research production came into focus, and the consolidation of the Disaster Risk Reduction field of research became central: - The PhD students used 2013 to finish their first half of their diploma work and summarising their projects in progress reports. These half-time progress reports have begun to be defended in Centre-wide seminars. Work continued to support the student s ability to perform inter-disciplinary work at a stage in their development when disciplinary priorities gradually have grown stronger. - The interface between CNDS and Swedish authorities, organisations, and industry was gradually strengthened by the continued implementation of the communication plan. The scientific quality of CNDS research in an international context was strengthened by (i) the first meeting of the International Advisory Group in May 2013 and by (ii) a strategy for international cooperation that will guide our forthcoming work. Please describe the major activities within the environment in 2013. (Question Q2) The major CNDS activities in 2013 were the same as in 2012, i.e., related to the research school, collaboration within CNDS and with Swedish authorities and industry, and establishment of CNDS on the international science scene. 154 (175)
- PhD students have started to present their half-time progress reports at centre-wide seminars with good results. This process will intensify during 2014 and all PhD students are now in production mode concerning their theses. - The 2013 CNDS Forum (Forum for Natural Disasters) was arranged a second time with almost twice as many participant as in 2012. This year it was co-sponsored by the Swedish National Platform for Disasters Risk Reduction, a coordination body for 19 Swedish agencies (increased to 20 in 2014) that share responsibilities in the disaster prevention area. - The CNDS Academy held two science meetings in 2013 with contributions from CNDS and other Swedish researchers/research centres related to risk-reduction research. One of the Academies was a two-day workshop in Karlstad, designed to develop interdisciplinary DRR research questions that could drive and refine the centre s work. - The work to update the CNDS web site to a more efficient external and internal communication centre was brought close to its completion by the end of 2013. The new web site will be launched early in 2014. - The planning for a Special Issue on Disaster Risk Reduction (DRR) of the international peer-reviewed Wiley journal Geografiska Annaler came to conclusion in 2013. The SI is edited by three CNDS PIs and the author list contains a mix of CNDS researchers and Swedish/international scholars. The Special Issue will be used to demonstrate the CNDS perspective of the research area, and will be a basis for an international scientific workshop in 2014. This workshop will be an extension of the CNDS Forum. - The National Advisory Group elaborated a strategy on industrial PhD students as a future connection between academia and stakeholders in the Swedish DRR area. - The International Advisory Group had its first meeting in May 2013 as a part of the UN/ISDR Global Platform meeting in Geneva. - CNDS established itself in a Nordic context as part in a consortium that submitted an application to become a Nordic Centre of Excellence in the field of Societal Security. The application was filed on 15 January 2014. This network, including, e.g., LUCRAM at Lund University, SEROS at the University of Stavanger, and VTT in Finland, will be a basis for future collaboration on Nordic DRR research. Please describe the major results within the environment in 2013. (Question Q3) 2013 was the year of mid-project progression for the majority of PhD students in the CNDS research school. The first six mid-term reports were ventilated in 2013 and another eight are planned for the first half of 2014. Some PhD students, who were already well into their studies at the start of the CNDS research school, got their diploma in 2013. Two licentiate theses (environmental analysis and information technology) and two PhD theses (hydrology and anthropology) were successfully defended. Four sub-projects funded by The Swedish Civil Contingency Agency (MSB) were successfully completed in 2013. They concerned development of wireless sensor networks for flexible remote sensing of flood risks, prerequisites for effective collaboration in Swedish municipalities during emergencies, impact of learning from disasters on policy development in Sweden and internationally, and the relation between collaboration and decision support for disaster risk reduction. Individual researchers/ groups within CNDS gained further momentum in their production of both disciplinary and inter-disciplinary research relevant for disaster-risk reduction of the Swedish society, as witnessed by a considerably increased publication list. 155 (175)
A mapping of international centres for DRR research was finalised in 2013. The evaluation of centres in terms of documented inter-disciplinarity and impact showed that only four such centres fulfilled all criteria which raised the question why there are so few fully inter-disciplinary centres globally. These questions have also been discussed internally within CNDS, when the cultural, structural and disciplinary barriers have complicated the inter-disciplinary progress of many research school students. The cooperation within the CNDS network of agencies and industry was further strengthened. A primary result is a concept for cooperation on funding industrial PhD students. The first such student (from the Swedish Transport Administration) was recruited to the CNDS research school in 2013. CNDS researchers were part of the Swedish delegation to the UNISDR Global Platform meeting in Geneva in May 2013 to support the establishment of a post-hyogo agreement. CNDS engaged in substantial contract education, training more than 200 high-level civil servants (managers, senior officials, diplomats from Partnership for Peace countries), some of which from Finland. CNDS members also helped authorities to formulate risk-reduction policies nationally and in Norway, and within EU through analytical support and method development as lessons learned from recent U.S. disasters. 156 (175)
19. Strategiskt forskningsområde: Transportforskning Huvudansvarig myndighet: Vinnova Samrådande myndighet: - År 2010 2011 2012 2013 2014 Total budget 25 50 80 80 80 Avsättning till infrastruktur 1 2 3 3 3 Budget efter avsättning 24 48 77 77 77 19.1 Chalmers Sustainable Transport Initiative Huvudsökande: Chalmers Tekniska Högskola, 85% Medsökande: Göteborgs universitet 15% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 46 266 000 Personell 28 787 000 Co funding from main applicant higher education institution 23 133 000 Running costs 4 298 000 Co-funding from-co-applicant higher education institution 3 470 000 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 1 409 000 Other costs 12 695 000 Other external funding Totalt: 45 780 000 Totalt: 74 278 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution. N.B an exhaustive list is not required. Goverment strategic research fundings include funding to co-applicant. Chalmers has chosen not to report the amount of external funding above because of the difficulty to produce figures that accurately reflect the funding situation in the strategic research area (SRA). This has several reasons, for example: (i) a fairly large portion of the researchers are involved in more than one AoA and their external grants might partly or entirely be used for projects in other areas, making it difficult to determine to what extent the external funding should be attributed to one or the other area, (ii) some researchers are involved in research within the area, but not directly associated with the AoA, and therefore do not report their results or external funding here. Also, (iii) external funding received by researchers involved in the area at our partner universities is difficult to determine and to include in a relevant way. 157 (175)
During 2013, Chalmers has investigated and considered several different models for reporting external funding to these environments, both by internal analysis and by conferring with some of the other involved Swedish universities. We have recently decided on a model for reporting external funding in a satisfactory and authentic way and will use this for reporting for the entire period of 2010-2013 during the self-evaluation in spring of 2014. Please state the main priorities within the environment in 2013. (Question Q1) The main priorities during 2013 have been set on (1) coordinating and organising the strategic research environment, (2) discussing continued research agendas, (3) preparing for Horizon 2020, (4) developing international collaborations, and (5) developing methods of describing and analysing the different ways in which our research is made useful to industry and society. The coordinating and organising issues concern how to involve and develop research centres including multiple external parties, with various expectations and perspectives, and how to engage additional external actor constellations in order to enable real and systemic change. Owing to Chalmers overall priority to organise cross- and multiple disciplinary research, education and innovation activities in eight Areas of Advance, the organising issue extends the scope of Transport. Moreover, important overlaps with other Areas of Advance e.g. Energy, Built Environment and ICT entail both possibilities and challenges for the future. Discussions of long-term research agendas have been, and are still, a main priority. Alignment with Sweden s long-term transport political targets (especially; fossil free traffic in 2050) and external partners short-term road maps present us with challenges. Our choice to use the strategic funding to boost the wide range of current research on sustainable transport at Chalmers and University of Gothenburg means that we are very much depending on other sources of funding. Therefore, a related priority is to interact with the main funding agencies in order to influence them to support our research directions and funding needs (e.g. funding of PhD students). Preparations for Horizon 2020 have engaged many researchers and research coordinators during 2013. Especially regarding road maps for European road safety (PROS) and in the new fields that have opened up for research collaboration and funding related for instance to the new logistics task force in EARPA the efforts to influence the calls and to participate in newly formed platforms and consortia has been a priority. In addition to Horizon 2020, other strategic international alliances and collaborations have been encouraged, particularity with China, Japan and the US and strategic collaboration has been established with Volvo Research and Education Foundation s Centre of Excellence in Urban Freight. Innovation in terms of the various ways in which research and higher education is made useful to industry and society is a key concern. During 2013 we have developed methods to describe and analyse our innovation outcomes and contributions. The range of such outcomes and contributions is wide and contains several units and levels of analysis, e.g. individual researchers/teachers, research groups, research centres and clusters of centres. The most important category of contributions, however, is made through our graduates and thus concerns our ability to provide educations of high quality and relevance. In 2013 the Swedish Higher Education Authority s evaluation of technical, engineering and architecture programs reported that Chalmers bachelor and master degrees were rated with high quality and that Chalmers ranked the highest among the Swedish universities. Efforts to further strengthen the connections between transport research and higher education continues to be in focus. 158 (175)
Please describe the major activities within the environment in 2013. (Question Q2) The main collaborations and activities described as major activities during 2012 continue. A great number of seminars, conferences and workshops on different topics have been carried out during 2013. In addition to continued research, education and innovation activities focusing on established research topics in Traffic safety, Transport efficiency and customer adapted logistics and Sustainable vehicle technologies a set of new themes identified in multi-disciplinary collaborations have surfaced and started to develop. Three such themes, each relating to a research profile, can be mentioned. (1) Changing transport service procurement (Transportinköpspanelen) has engaged researchers at Chalmers, University of Gothenburg and the Swedish Environmental Institute (IVL) and spurred an interest in industry among buyers of transport services. The potentials in changing the demand for transport services through adjustments in logistics, purchasing and production has also been highlighted in the FFF-commission report. (2) Automated driving as a tool for accident free and efficient road traffic has become a hot topic both among our ICT-related transport researchers and our partners in the automotive industry. Master s courses on the subject have been developed and attract a lot of students. (3) Butanol as a potential bio-based transport fuel has become a research theme that engages researchers from several research centres involving research on combustion engines, catalysis and production of renewable fuels. There are many more examples of research initiatives and activities in the strategic research community but we consider these to be good examples of research areas with great potentials for future sustainable transport solutions and research themes that we would not have been able to initiate without the strategic research funding. Please describe the major results within the environment in 2013. (Question Q3) In the profile Traffic Safety important databases are built up with in-depth data on accidents and naturalistic driving data from vehicles and two-wheelers. Research results include methods for analysis of crash causation, cyclist behaviour in city traffic, event-based naturalistic driving data processing, response time in critical situations, novel methods to address crash severity, detection of intracranial bleedings. Accident avoidance research present results on the relationship between human beings and technical systems and regarding drivers' reactions on technical errors/failures. The plethora of technology results include new algorithms for threat assessment, for decisions in automatic braking or steering manoeuvres and robust decisions in uncertain situations as well as methods for testing on-board vision systems and design of consensus protocols for autonomous systems. Injury prevention results include FE models for child occupants, a unique method for experimental whiplash research, experimental data for the active human body modelling and a novel seat belt sensor system. In the profile Transport efficiency and customer adapted logistics new concepts and research results supporting sustainable development have been achieved in e.g.: design and implementation of materials planning as well as material supply systems, product recovery, transport purchasing for reducing the carbon footprint, service concept development, foliated control in transport networks, smart transportation management and Freight ITS concepts, urban distribution design and evaluation. Important results are also related to human behaviour and methodologies e.g. for materials flow mapping and total cost calculation including internalisation of external costs In the profile Sustainable Vehicle Technologies cross-disciplinary collaborations has been established, both between research centres, but also between traditionally separated departments within Chalmers. For example, when developing hybrid vehicle solutions, collaboration has emerged between research groups that optimise the combustion engine and research groups that optimising the electric engine. Another example is collaboration that has been initiated in order to develop and test materials for lithium-sulphur batteries for the next generation energy storage. Furthermore, collaboration aiming at reducing emissions from shipping has emerged where results from distant measurements via satellites are compared to direct measurements on board the ship. Results supporting sustainable development have been achieved in the topics of (i) Efficient Powertrain, e.g., engine research, control, fuels in engines, after-treatment systems, transmission, 159 (175)
hybridization, and electrification, (ii) Vehicle concept development, e.g., resistance and propulsion (incl aerodynamic, hydrodynamic), structure and materials, system engineering, noise reduction, and maintainability, as well as (iii) System aspects of vehicles, e.g., environmental systems assessments (incl. LCA, energy modelling), control and monitoring systems in vehicles, emission measurements and human factors. 160 (175)
19.2 TrenOp, Transport Research Environment with Novel Perspectives Huvudsökande: Kungliga Tekniska Högskolan 79% Medsökande: Linköpings universitet 21 % a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 31 000 000 Personell 19 658 000 47 630 000 Running costs 3 775 000 Co-funding from-co-applicant higher education institution 13 200 000 High cost Equipment 101 000 Funding from collaborating research institutes 0 Infrastructure running costs 1 774 000 Funding from other collaborators 0 Other costs 7 297 000 Other external funding 163 279 000 Totalt: 32 605 000 Totalt: 255 109 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Summa (tkr) Funding from public agencies 100 703 Public research fundations 10 857 EU 19 146 Other international funding 1 657 Private non-profit organisations 8 971 Private companies 19 248 Other 2 698 Summa 163 279 Please state the main priorities within the environment in 2013. (Question Q1) The main priorities of TRENoP have continued to be faculty renewal, establishment of interdisciplinary connections, links between with academia, industry and society in the field, and connecting research and education. The faculty renewal process is almost complete, with several new recruitments through international competitive processes. All TRENoP positions are in cross-disciplinary areas of emerging importance, as a part of the overall TRENoP goal to create closer links between different fields of transportation research. Crossdisciplinary connections are further enhance by arranging the Stockholm International Transport Summit, an 161 (175)
invitational think-tank with leading international thinkers from research and industry focusing on major future challenges and transitions. The ties to industry and society have been strengthened through a large number of joint projects and activities. These include both joint technical R&D with several major Swedish companies and public agencies, and analysis of public investments and policies in collaboration with public agencies and other stakeholders. Several new initiatives have been made to further integrate research and both graduate and undergraduate education, for example the itrue program where undergraduate students participate in research projects, and arranging international scientific conferences in conjunction with education. Please describe the major activities within the environment in 2013. (Question Q2) An important focus during 2013 has been to continue the faculty renewal process by coaching and providing good conditions for the new TRENoP recruitments so they can advance in their academic career and become promoted. In fact, several of the assistant professors have already been promoted to associate professors. The seed projects initiative from 2012 resulted, as intended, in several new cross-disciplinary collaborations. In 2013, these have been funded through project funding to specific groups and centres, and through faculty funding for the TRENoP positions. Substantial funding has been allocated to research centres in 2013. These centres act as instrument to further strengthen ties between academia, to industry and society through joint research projects, industrial PhDs, contract education, advice to policy makers etc. The new funding has been used for a number of large joint projects in collaboration with public and industry stakeholders. During 2013, KTH and Scania expanded their collaboration further, developing a joint strategic research program, involving 10-15 joint research groups with both KTH and Scania staff working on a broad range of topics. Another joint research program developing In 2013 was the collaboration with the Transport Administration on transport modeling and appraisal, where KTH s Centre for Transport Studies have played an integral part both developing and coordinating substantial parts of the R&D program together with the Transport Administration. TRENoP has taken a number of initiatives to further increase integration between research and education, for example through itrue, where undergraduate students can be funded by TRENoP to work in research projects with senior researchers. Following the success in 2012, the funding for itrue was expanded in 2013. In the fall of 2013, the KTH International Transportation Summit was organized. The Summit is an annual, twoday invitational think-tank, where around 15 international experts from academia, industry and politics were invited to discuss the long-term development of the transport system and its interaction with society. A book is planned, based on the discussions and contributions from the Summit meetings. KTH established a joint virtual campus with Tsinghua University, one of China s most prestigious universities. The C-campus, as it is called, started its activities during the year, and will be a platform for joint education and student collaboration. KTH and Linköping University have recently established the new major research program Railway Capacity Analysis (KAJT) together with the Transport Administration and industry partners. The first full-scale projects were carried out in 2013, affecting several kinds of policy decisions and processes. 162 (175)
Please describe the major results within the environment in 2013. (Question Q3) The scope of the TRENoP program is broad, and results contain a vast range of improvements and discoveries. At an early stage, it is often difficult to judge what the most important results will be in the long run. Still, our selection of the most promising or important results from 2013 would include: - The current railway capacity allocation process ( tåglägestilldelningen ) was analysed, showing that the problems it has experienced are principally impossible to solve, resulting in suggested new approach to be developed and implemented further on. - A systematic identification of points which are crucial for the robustness in a railway timetable, and a method for distribution of available slack time between train services in order to achieve a more robust timetable. - Development of methods and systems for estimating traffic demand and travel performance based on cellular network data - The evaluation of the impact of the Göteborg congestion charges, and the proposed revised design of the Stockholm congestion charges (adopted by the Government at the time of writing). - Identified effects of the Stockholm congestion charges' clean vehicle exemption on car choice, extent of travel, and greenhouse gas emissions. - A new energy based computational model has been formulated to analyze and optimize the self-healing capacity of asphalt mixtures. - A new gaming and participatory simulation framework for Big Data analysis in Digital Cities has been developed. - A new experimental and computational ageing framework has been developed to allow for the reduction of premature damage in asphalt. - An online platform has been developed and tested in the cloud in collaboration between Tsinghua and KTH. In the course, 30 KTH and Tsinghua students made designs for a future highway. - A new method on how to describe city logistics as a system has been developed. 163 (175)
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20. Strategiskt forskningsområde: Vårdforskning Huvudansvarig myndighet: Samrådande myndighet: Vetenskapsrådet FAS År 2010 2011 2012 2013 2014 Total budget 25 40 50 50 50 Avsättning till infrastruktur 0 0 0 0 0 Budget efter avsättning 25 40 50 50 50 20.1 Toward Person-Centered Care in Long-term Illness: A Research Core Center Huvudsökande: Göteborgs universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 20 000 000 Personell 14 938 000 Co funding from main applicant higher education institution 10 000 000 Running costs 7 403 000 Co-funding from-co-applicant higher education institution 0 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 16 000 Funding from other collaborators 0 Other costs 10 362 000 Other external funding 3 652 000 Totalt: 32 719 000 Totalt: 33 652 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution N.B an exhaustive list is not required. Vinnova financed the GPCC project: Testbeds in Health Care, Person-centred Reference Wards. EU FP7-Health-2013-Innovatiaion have financed project: WE-CARE Towards a Sustainable and Affordable Healthcare. Forte financed projects: Integrating person-centered care in health science education programs and Development of EU application with a multi-disciplinary program for sustainable healthcare. Please state the main priorities within the environment in 2013. (Question Q1) The University of Gothenburg Centre for Person-centred Care (GPCC) is an interdisciplinary research centre, gathering around 130 national and international researchers in some 30 different research projects which all have their basis in the common theme Person-centred care (PCC) in long-term illness. The centre s research has proven that PCC is a high quality and cost effective care. 165 (175)
Healthcare costs in Europe have increased by 27% in the years 2005 to 2010, and it is estimated that the total cost of hospital care in Sweden will increase dramatically (by 270 percent from 2010 to 2040). With this is mind our main priorities have been: 1. To perform, stimulate and bring together research that validates the concept and implementation of PCC. 2. To reinforce collaborations nationally and internationally in order to replicate, further develop and implement research results performed by GPCC over the whole care chain. 3. To develop innovations and educational packages and to make health professionals, policy makers, patient organizations and the general public aware of GPCC s activities and findings. Please describe the major activities within the environment in 2013. (Question Q2) The aim of the activities described below has been to achieve a major shift of paradigm in the culture of health care to improve quality and effectiveness of care nationwide and on an international level, as well as continued and expanded research including new studies on the effect of person-centred care (PCC) in health care. * Performing high-quality, world-leading research about PCC. More than 130 national and international researchers worked on 34 different research projects resulting in 450 international scientific publications and participation in a large number of conferences ranging in specialist disciplines from World Congress in Paediatric Cardiology & Cardiac surgery via the 5th International Conference on Self-Determination Theory to WHO inititative HPH Health Promoting Hospitals. * Formulating health care strategies on a European level. GPCC was invited by the European commission to lead the development of a new R&D Strategic plan and Roadmap on cost containment of healthcare with maintained or improved quality, as a part of the development of Horizon 2020. In September 2013 the consortium WE-CARE was formed as an EU-wide network. WE-CARE is coordinated by GPCC and involves care providers, policy makers, academic partners, insurance companies and industry giants like IBM and IMEC. Further Inger Ekman has been appointed vice-president of newly formed European Society of Person-centred Healthcare. * Taking an active role in health care policy on a national level. During 2013 GPCC contributed to the governmental reports The Swedish Agency for Health and Care Services Analysis and The patient power investigation (SOU 2013:2). GPCC also contributed to the development of the newly launched government initiative for persons with chronic illness, by invitation from the Ministry of Health and Social Affairs. * Disseminating the concept of PCC to a wide spectrum of health care professionalss, politicians and society.apart from active participation staging seminars at national forums like Almedalen week and Kvalitetsmässan, the textbook Personcentrering i hälso- och sjukvård; från filosofi till praktik (Personcentredness in Health care; from philosophy to practice) (Inger Ekman, Ed.) was written during 2013. It gathers the major findings, experiences and knowledge of the authors from the research centre and beyond on this subject. The book is aimed at a wide range of potential readers. It was published in the beginning of 2014 and will in the future be translated into English and launched internationally. * Presenting GPCC and PCC, including research results and educational and working methods, to the general public.gpcc actively worked to gain public awareness as seen by articles in a number of newspapers and journals such as Dagens Medicin, Dagens Samhälle and Dagens Nyheter, as well as seminars, social media, webinars and internet resources with SALAR (SKL) and SVID. 166 (175)
Please describe the major results within the environment in 2013. (Question Q3) Research: * Research is being conducted in the whole care chain, for example evaluation of person-centred care in a controlled study among elderly in community care with focus on incontinent persons as well as a study evaluating the effects of person-centred care on sick leave after myocardial infarction. * New research areas have been developed including effects of PCC in acute psychosis. * 450 international scientific publications. Utilization/Implementation: * Reference wards for person-centred care: Results from completed controlled studies from GPCC have presented how person-centred care can make care more effective and with a higher quality raised expectations and demands from the health care sector to implement and test the results. An implementation program has been developed and put into place at the Sahlgrenska University hospital/östra (SU/Östra) within the Department of Internal medicine. With support from VINNOVA and in collaboration with SU/Östra, Astra Zeneca, IBM and Doberman (a design-company), two national reference wards for person-centred care (PCC) were initiated to function as living labs ; test-beds for innovation. These reference wards received a great deal of media attention and were also visited by representatives from the government (Ministry of Health and Social Affairs), funding agencies (FORTE) and other hospitals. Measurement of mean hospital stay and patient satisfaction with care showed significant improvement. * Representatives from several county councils (eg. Sörmland, Halland, Gotland) and hospitals (eg. Karolinska Institutet and Allingsås Lasarett) within counties approached GPCC in order to learn more about the implementation program for person-centred care. * Person-centred care remains high on the national and international agenda, and GPCC has contributed significantly to the increased awareness of and interest in PCC nationally. Other organisations are now highlighting our work. For example SKL (the Swedish Association of Local Authorities and Regions - SALAR) published a web page devoted to GPCC and person-centred care under the subject heading democracy ; SVID (SVID, the Swedish Industrial Design Foundation ) announced the GPCC a Swedish spearhead; Stockholms Sjukhem organized a closed, invite-only round-table talk on person-centred care in Almedalen, with the GPCC Centre Director as the main speaker. * Major national and international academical and industry partners are now contacting GPCC wanting to collaborate, for example Radboud University Medical Center Nijmegen, Netherlands, Forum för Health Policy, newly formed Swedish Forum for Welfare (Forum för Välfärd) and Cordiva Gesellschaft für Patientenhilfe, Germany. Education: * With support from FORTE integration of person-centred care (theory and practice) has been started and a program to implement person-centred care into four programs (physician, nurse, physio-therapy, occupational therapy) at the Sahlgrenska academy has been developed. * With support from FORTE a project aiming to develop a research program that will prepare future healthcare research to contribute towards sustainable, affordable and high quality healthcare has been initiated. Swedish academia, politicians and industry have been invited to submit ideas on the subject which will be discussed also with international partners in April 2014 and used in a strategy and roadmap on research questions for the future health care aiming at Horizon 2020. 167 (175)
* Implementation and change programmes for person-centred care, invented and tailor made by the GPCC to individual care settings, continue to be developed and are in high demand. Funding: * GPCCs external funding during 2013 increased by 383% compared to 2012; 2012 it was 756,000 SEK, 2013 it was 3,6 million SEK. 168 (175)
20.2 Bridging Research and Practice for Better Health: The Comprehensive Care Science Centre Huvudsökande: Karolinska Institutet 80% Medsökande: Umeå universitet 20% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding Co funding from main applicant higher education institution 20 273 000 Personell 18 476 000 12 465 165 Running costs 1 930 000 Co-funding from-co-applicant higher education institution 1 200 000 High cost Equipment 0 Funding from collaborating research institutes 2 696 297 Infrastructure running costs 0 Funding from other collaborators 20 614 674 Other costs 3 571 000 Other external funding 114 490 373 Totalt: 23 977 000 Totalt: 171 739 509 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution.n.b an exhaustive list is not required. The biggest financial contributors under the category of "external funding" are: 1. FORTE/FAS 2. VR 3. SIDA 4. OLLE ENGQUIST 5. VINNVÅRD Please state the main priorities within the environment in 2013. (Question Q1) The main priorities of the Strategic Research Environment in Healthcare Research (Strategiska forskningsområdet Vård; SFO Healthcare) have been to: 1) Provide financial support to top researchers in the core areas described below 2) Support renewal and build research capacity at Karolinska Institutet (KI) and Umeå University (UmU) through the provision of funds to younger researchers Healthcare Research encompasses several academic disciplines, utilizes a diversity of methodological approaches, and contributes to the scientific knowledge base of a number of professions in health and social care. 169 (175)
Healthcare Research at KI and UmU mirrors the human lifespan and focuses on research in the following five core areas: 1) Women and child health 2) People living with long-term disability 3) Older adults living with activity limitations and participation restrictions 4) Cancer nursing and palliative care 5) Health systems, policy, management, informatics and economics Each of the five core areas includes between 20 100 active researchers on all academic levels from PhD candidates and post-docs to full professors. There are in all over 450 active researchers in the Healthcare Research environment. During 2013 the top 11 research groups in the field at KI, selected in a peer-review process, have been funded. At UmU the program has funded 3 post-doc positions. Please describe the major activities within the environment in 2013. (Question Q2) The two major funding programs of SFO Healthcare are mentioned above. Other activities and developments in the environment include: establishment of new contacts with the business sector and the wider society of local care providers in the Stockholm region, as well as governmental agencies. New initiatives to support the international collaboration of young researchers were taken. KI won in a highly competitive process, on an application prepared by SFO Healthcare, an Investor AB donation for a new professorship in Innovative Care. The chair with supporting resources will be connected to and contribute to SFO Healthcare. This new activity will contribute to initiation of long term structures for collaboration between Healthcare research at KI in collaboration with other universities and the care providers in the greater Stockholm region. With its focus on social and organizational innovations, this new activity will support the implementation of measurement tools, as well as diagnostic, therapeutic and rehabilitation methods developed by healthcare science research into clinical practice. The professor ship will also facilitate further dissemination of those inventions nationally and internationally. It will also provide a channel for local improvement initiatives to be recognized, tested and developed into products and services to be used more widely. Initiatives to set up sustainable local programs for improved care has been made during 2013. Contacts in the business sector include working in close contact with Karolinska Institutet Innovations AB, Kunskapslotsen AB and Flemmingsbergs Science, organizations that allocate resources to bridge the gap between academia and business. New contacts have also been developed with NGOs in the region, mainly patient and client group organizations in the areas of arthritis, diabetes and heart failure care, as well as mental health and dementia. Recruitment of new international collaborators in Healthcare Research has taken place during 2013. One strategy to attract international new researchers to KI and UmU has been to invite them through the Global Bridges program. SFO-V has allocated funds to this program for junior faculty at KI and UmU, enabling the invitation 10 international top researchers of their choice to visit KI. The purpose behind this activity is to enable junior researchers to connect to research internationally, and pave the way for post-doc positions as well as plans for extended exchange. The Program has also created of a meeting-place for researchers at KI and UmU with shared interest in Healthcare Research. We strongly believe that this initiative will increase all international contacts among the group of younger researchers in Healthcare Science. 170 (175)
Please describe the major results within the environment in 2013. (Question Q3) SFO Healthcare has created a meeting place for researchers in health and social care enabling them to share experience, to build capacity and it has succeeded in further enlarging the critical mass of senior and junior scientists. SFO Healthcare research groups won a total of 171 768 509 SEK in research grants (including the SFO contributions). The number of new PhDs during 2013 at KI and UmU are in total 40 of which 37 are women. The high number of women mirrors the field of healthcare where women still are in the majority, although more could be done by national politics to make the field more attractive also for men. Original publications in international peer-reviewed journals counted to 482. The 2013 funding program, awarding the 11 most successful research groups of the research environment, will support the transition of skills and responsibilities from very senior to mid-career and junior researchers. All the funded groups address in their research major challenges in society, not only in Sweden but also globally, especially in low income countries. Projects that are initiated are for example The health of mother and new born children in Sweden and low income countries and Children and families living with disabilities. A high number of projects are intervention and implementation studies where new approaches to treatment are developed and tested in various environments, in hospitals, outpatient clinics, in primary care as well as in care for older people in local communities. These novel approaches are focused on all ages and include people living with long-term diseases, older adults as well as very young children. Management oriented studies include the application of lean in improving healthcare provision, new value-based reimbursement models, the ethics of selfdetermination among patients, e-health and decision-support for multi-professional teams. Thanks to SFO Healthcare research the Stockholm County is an international front-runner in value-based healthcare funding (paying for clinical outcomes). Recent examples are the introduction of reimbursement of knee and hip replacement surgery which keeps the provider responsible for managing possible complications, and payment for spine surgery being dependent on patient reported pain six months postoperatively. The donation of Investor AB, enabling the establishment of a chair in innovative care, demonstrates that SFO Healthcare has succeeded in creating a high-performing research environment, highly appreciated by, in this case, the owner of a nation-wide chain of private providers of health and social care. 171 (175)
20.3 U-CARE: Better Psychosocial Care at a Lower Cost? Evidence-based assessment and Psychosocial Care via Internet, a Swedish Example Huvudsökande: Uppsala universitet 100% a. Income of the strategic research environment 2013 (all income, Question C3a) b. Costs of the strategic research environment 2013 (regarding Government strategic research funding, Question C3b) a. b. Funding category Funding in SEK Cost type Cost i SEK Government strategic research funding 10 000 000 Personell 7 900 000 Co funding from main applicant higher education institution 5 500 000 Running costs 0 Co-funding from-co-applicant higher education institution 0 High cost Equipment 0 Funding from collaborating research institutes 0 Infrastructure running costs 0 Funding from other collaborators 1 000 000 Other costs 2 143 000 Other external funding 4 200 000 Totalt: 10 043 000 Totalt: 20 700 000 Please specify the types of funding sources included in "Other external funding" from the table above, together with a rough estimate of their relative contribution..n.b an exhaustive list is not required. U-CARE other external funding for 2013, mentioned under C3.a. Principal investigator von Essen Swedish Research Council: Project grant Swedish Cancer Society: Project grant Swedish Childhood Cancer Foundation: Project grant 1 000 000 SEK 600 000 SEK 300 000 SEK Principal investigator Ljungman Swedish Childhood Cancer Foundation: Senior research position 650 000 SEK Swedish Childhood Cancer Foundation: Project grant 750 000 SEK Principal investigator Johansson Swedish Cancer Society: Project grant 500 000 SEK Income from associated researchers for use of U-CARE-portal: 400 000 SEK Associated researchers external funding for 2013 for U-CARE related research, not mentioned under C3.a. Principal investigator Associate professor Åberg: Stiftelsen Promobila: Project grant 150 000 SEK Principal investigator Associate professor Rubertsson: Funds for Caring research, Uppsala University: Project grant 400 000 SEK; and ALF-nämnden Uppsala County Council: Project grant 182 000 SEK Principal investigator Associate professor Skoog Svanberg: Regional research council: Project grant 300 000 172 (175)
SEK; and Funds for Caring research, Uppsala University: Project grant 200 000 SEK Principal investigator PhD Holländare: The Swedish Social Insurance Agency: Project grant 1 100 000 SEK Please state the main priorities within the environment in 2013. (Question Q1) Main priorities 2013 Provide stimulating and challenging career opportunities for young Swedish and international researchers and students. Recruit system developers to work with the U-CARE portal. Start and complete feasibility studies, pilot studies, and randomized controlled trials via the U-CARE portal. Consolidate cross-disciplinary research from the academic fields: Caring Sciences; Economics; Implementation Science; Information Systems; and Psychology. Provide access to the U-CARE portal to associated researchers at Uppsala University, other Swedish universities and health care organizations. Consolidate research collaborations with researchers at Radboud University, Nijmegen Medical Centre, the Netherlands; University of Groningen, University Medical Centre Groningen, the Netherlands; Vrije Universiteit Amsterdam, the Netherlands; University of Exeter, UK; Innovation Value Institute, Ireland; University of Miami, USA; University of South Florida, USA; and Stanford University, USA. Attract major external funding for 2014 and onwards. Implement involvement of members of the public in U-CARE research activities. Submit and publish a larger number of original publications, conference papers, and other publications than 2012. Support activities within the cross-disciplinary, trans-faculty research school Psychosocial Care in the Interactive Society with nine PhD students partly financed by strategic funding to U-CARE and partly by the Department of Economics; Department of Informatics and Media; Department of Psychology; and the Disciplinary Domain of Medicine and Pharmacy, Uppsala University respectively. Provide part II of the high-quality research-based, cross-disciplinary PhD course in Psychosocial care in the interactive society. Provide a high-quality research-based, cross-disciplinary PhD course in Implementation of complex interventions in collaboration with scholars at Radboud University, Nijmegen Medical Centre, the Netherlands. Consolidate implementation of high-quality research-based, cross-disciplinary education in psychosocial care in the interactive society in the educational programs for nurses and psychologists and the Master Program in management, communication, and IT. Build up a high-quality research-based, cross-disciplinary PhD course in sustainable citizen-centered health care via information and communications technology. Build up high-quality research-based, cross-disciplinary education in psychosocial care in the interactive society for the educational program for physicians and the Master Program in public health. Establish U-CARE as a health care provider. Re-organize U-CARE to support theoretical depth as well as cross-disciplinarity in research. Re-organize U-CARE to promote leadership to increase educational and research output and share U-CAREs work on a national and global scale. Re-organize U-CARE to increase access to the U-CARE deliverables i.e. the U-CARE portal and psychological/psychosocial interventions. Please describe the major activities within the environment in 2013. (Question Q2) Major activities 2013 Providing stimulating and challenging career opportunities for young Swedish and international researchers and students. Recruiting system developers to work with the U-CARE portal. Starting and completing the feasibility study for the randomized controlled trial (RCT) TeenCan via the U-CARE portal. Starting and completing the pilot study for the RCT AdultCan via the U-CARE portal. Starting the pilot study for the RCT Heart via the U-CARE portal. Starting the pilot study for the RCT JUNO (PI associated researcher) via the U-CARE portal. Starting the RCT AdultCan via the U-CARE-portal. Providing access to the U-CARE portal to associated researchers at Uppsala University, other Swedish universities and health care organizations. 173 (175)
Attracting major external funding for 2014 and onwards. Implementing involvement of members of the public in U-CARE research activities. Writing and submitting original publications, conference papers, and other publications. Supporting activities within the cross-disciplinary, trans-faculty research school Psychosocial Care in the Interactive Society with nine PhD students partly financed by strategic research funding to U-CARE and partly by the Departments of Economics; Department of Informatics and Media; Department of Psychology; and the Disciplinary Domain of Medicine and Pharmacy, Uppsala University respectively. Providing part II of the high-quality research-based, cross-disciplinary PhD course in Psychosocial care in the interactive society. Providing the high-quality research-based, cross-disciplinary PhD course in Implementation of complex interventions in collaboration with scholars at Radboud University Nijmegen Medical Centre, the Netherlands. Consolidating implementation of high-quality research-based, cross-disciplinary education in psychosocial care in the interactive society in the educational programs for nurses and psychologists and in the Master Program for management, communication, and IT. Building up a high-quality research-based, cross-disciplinary PhD course in sustainable citizen-centered health care via information and communications technology. Building up high-quality research-based, cross-disciplinary education in psychosocial care in the interactive society for the educational program for physicians and the Master Program in public health. Establishing U-CARE as a health care provider. Re-organizing U-CARE to support theoretical depth as well as cross-disciplinarity in research. Re-organizing U-CARE to promote leadership to increase educational and research output and share U-CAREs work on a national and global scale. Re-organizing U-CARE to increase access to the U-CARE deliverables i.e. the U-CARE portal and psychological/psychosocial interventions. Holding the third meeting with the U-CARE Scientific Advisory Board and all U-CARE members. Holding a seminar on public involvement in research during the Almedalen week. Please describe the major results within the environment in 2013. (Question Q3) Major results 2013 Ten post doc researchers and eighteen PhD students have been provided stimulating career opportunities within U-CARE. A PhD student from University of Groningen, University Medical Centre Groningen, the Netherlands and a MSc in psychology from Radboud University, Nijmegen Medical Centre, the Netherlands have visited U-CARE. Two system developers have been recruited. The feasibility study for the RCT TeenCan has been completed via the U-CARE portal. The pilot study for the RCT AdultCan has been completed via the U-CARE portal. The pilot study for the RCT Heart has started via the U-CARE portal. The pilot study for the RCT JUNO (PI associated researcher) has started via the U-CARE portal. The RCT AdultCan has started via the U-CARE portal. Two research groups have been associated to U-CARE to get access to the U-CARE portal. Major external funding has been attracted for 2014 and onwards by U-CARE and its associated researchers. Involvement of members of the public has been implemented in U-CARE research activities. Seventy original peer-reviewed publications have been accepted/published, thirty-seven peer-reviewed contributions have been presented at scientific conferences, and twelve other publications have been accepted/published. The third meeting with the U-CARE Scientific Advisory Board and all U-CARE members has been held. Four research seminar series have been arranged. Part II of the high-quality research-based, cross-disciplinary PhD course in Psychosocial care in the interactive society has been provided. High-quality research-based graduate education in Implementation of complex interventions has been provided in collaboration with scholars at Radboud University, Nijmegen Medical Centre, the Netherlands. High-quality research-based, cross-disciplinary education in psychosocial care in the interactive society has been further implemented in the educational programs for nurses and psychologists and in the Master Program for management, communication, and IT. A high-quality research-based, cross-disciplinary PhD course in sustainable citizen-centered health care via information and communications technology has been built up. High-quality research-based, cross-disciplinary education in psychosocial care in the interactive society for the 174 (175)
educational program for physicians and the Master Program in public health has been built up. U-CARE has been established as a health care provider. U-CARE has been re-organized to support theoretical depth as well as cross-disciplinarity in research. U-CARE has been re-organized to promote leadership to increase educational and research output and share U- CAREs work on a national and global scale. A seminar on public involvement in research has been held during the Almedalen week. Professor Theo van Achterberg, Katholieke Universiteit Leuven, Leuven and Radboud University, Nijmegen Medical Centre, the Netherlands member of U-CAREs Scientific Advisory Board has been recruited as a guest professor at the Department of Public Health and Caring Sciences, Uppsala University. 175 (175)