Hematopoietic Stem Cell Transplantation in Mainland China



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Hematopoietic Stem Cell Transplantation in Mainland China On behalf of CSBMT and CMDP October, 2014 APBMT Hangzhou

HSCT Units in Mainland China n =110

Distribution of Transplant Numbers Hangzhou Others Beijing 2012, 60 centers, n=3236

Types of HSCT Syngeneic 0.2% Matched Sibling 29.8% 2012, 60 centers, n=3236

Disease being Transplanted 2012, 60 centers, n=3236

China Marrow Donor Program By the end of July 2014 CMDP databank has reached 1.86 million donors. Transplant 4352 cases. Oversea donation: 130 cases. (CMDP)

CMDP Joined WMDA Has uploaded 680,000 donors HLA data to BMDW Since July 2012

OS Overall Survival CMDP Annual Meeting 2011 n=1483 Time post- HSCT OS (%) 3 months 84.7 1 year 70.7 2 years 65.2 5 years 55.9 Months after HSCT

CB Bank and CBT 10 CB banks (public, private) No government financial support 6 CB banks link to CMDP Application (3 rd party cells, transplant, cellular therapy) More than 100 CBT/yr

Cord blood transplantation Matched sibling CBT in AML (1998, Henan) Unrelated CBT in ALL (2000, Anhui)

Double cord blood transplantation ALL, 95kg (2000, Beijing) Follow-up in 2010

LFS & OS of Haplo-BMT Ludaopei Hematology & Oncology Center 77.8% 81.9%

LFS of AML after Haplo-BMT Ludaopei Hematology & Oncology Center 90.9% 72.7% 72.7% p=0.07% n=37, p=0.07 n=37

LFS of ALL after Haplo-BMT Ludaopei Hematology & Oncology Center 91.3% 91.3% 31.3% n=32, p<0.01 n=32 31.3%

The 1 st BMT in China

The 50 th Anniversary of BMT in China (1964-2014)

Saving lives since 1964

Acknowledgement 307 Hospital of PLA Affiliated Hospital of Guiyang Medical College Anhui Provincial Hospital Beijing Cancer Hospital Beijing Chao-Yang Hospital Beijing Friendship Hospital Changhai Hospital Chinese PLA General Hospital Department of BMT, Institute of Hematology, CAMS & PUMC Department of Lymphoma & Myeloma, Institute of Hematology, CAMS & PUMC Fujian Medical University Union Hospital Fujian Provincial Hospital General Hospital of Beijing Military Region Guangdong General Hospital Hainan General Hospital

Acknowledgement Harbin Institute of Hematology & Oncology He Nan Cancer Hospital He Nan Provincial People's Hospital Jiangsu Province Hospital Kunming General Hospital of PLA Ludaopei Hematology & Oncology Center Nan Fang Hospital (Pediatric) Nanjing Drum Tower Hospital Navy General Hospital Ningbo First Hospital Peking University People's Hospital Peking University Third Hospital Qilu Hospital of Shandong University Ruijin Hospital Shandong Provincial Hospital

Acknowledgement Shangdong Provincial Qianfoshan Hospital Shanghai Changzheng Hospital Shanghai Children's Medical Center Shanghai Daopei Hospital Shanghai Huashan Hospital Shengjing Hospital of China Medical University Sun Yan-sen Memorial Hospital, Sun Yat-sen University The 309th Hospital of Chinese People's Liberation Army The Affiliated Hospital of Qingdao University The First Affiliated Hospital of Chinese PLA General Hospital The First Affiliated Hospital of Dalian Medical University The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of Medical College of Xi'an Jiao Tong University The First Affiliated Hospital of Soochow University The First Affiliated Hospital of Zhejiang University

Acknowledgement The First Affiliated Hospital of Zhengzhou University The First Hospital of China Medical University The Second Artillery General Hospital of Chinese PLA The Second Hospital of Hebei Medical University Tianjin First Center Hospital Tianjin Medical University Cancer Institute and Hospital Tongji Hospital West China Hospital West China Women's and Children's Hospital Xiangya Hospital Central South University Xijing Hospital Xinqiao Hospital Third Military Medical University Zhejiang Provincial Hospital of Traditional Chinese Medicine Zhongshan Hospital of Xiamen University Zhujiang Hospital of Southern Medical University