TARADON Laboratory s.p.r.l.



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TARADON Laboratory s.p.r.l.

Secretion liquids The secretion liquids are important systems of the primary defense for the health in animals and in humans They exert host protective effects They have various biological activities

Molecules In all secretion liquids, we have found almost the same molecules: Lactoferrin (LF) Lactoperoxidase (LP) Lysozyme (Lys) Superoxide dismutase (SOD) Xanthine oxidase (XOD) Immunoglobulins: IgG, IgA, IgM, IgE Growth factors: EGF, IGF, IGF I&II, FGF..

Molecules As the first industrial producer in the world of lactoferrin and lactoperoxidase(1985), we have decided to focus our activities on the development of these two very important molecules contained in the secretion liquids, and so we have studied their activities of these two molecules: Lactoperoxidase: part of an antibacterial system (LP-s) Lactoferrin

History 1970 : University of Brussels, study on secretion liquids 1976 : Industrial production of egg white lysosyme (Belovo) (Award) 1984 : First Worldwide industrial production of lactoferrin and joint venture (Sud-lait - Oleofina - Sodelac) (Award) Lactoperoxidas 1985 : First industrial sale contract with Morinaga (Japan) 1987 : Oleofina stops its diversification Creation of Biopole 1990 : Starting of business of Biopole 1994 : 2nd industrial production of LF and LP : Biopole - Domo foods Ingredients 2000 : Launching of BioXtra (Bio-X Healthcare) 2002 : Launching of Food Supplements ADILA (Biopole) Development of Catallix (TMI EUROPE-Biopole) 2004 : Launching of clinical trials of the LF Hepatitis C and Cancer 3rd Industrial production of LF and LP : Biopole Milk Cooperative 2006 : Launching of clinical trials of the LP system Helicobacter Pilori 2007 : Dossier Novel Food for lactoferrin introduced 2008 : Launching of the 2 nd generation of the LF-NFQ Creation of Taradon Laboratory to promote Lactoferrin-NFQ 2009 : Launching trials of the LP system pre-harvest crops 2009 : Approval as Orphan Drugs for the mixture LF and OSCN- (Cystic Fibrosis)

LACTOFERRIN: our Star product A protein extracted from milk

Lactoferrin Antibacterial activities Antiviral activities: hepatitis C Iron binding property Regulation of intestinal iron absorption Improve the immune defence Antioxidant activity 7

Biological functions of lactoferrin Antitumor Immunomodulator Anti-Inflammatory Antibacterial activity Iron regulation Lactoferrin Protease Inhibitor Prebiotic Antioxidant activity Growth promotor on cells Antiviral

Lactoferrin Applications Baby/infant milk (the best in terms of volume) Baby food developped with customers from 1986 to 2007 Dairy product (yoghurt) Food supplements Food supplements ADILA developped from 2005 to 2007 Yoghurt developped with customers from 2002 to 2007 Oral Care products (toothpaste, mouthrinse, ) Cosmetics Oral care products bioxtra developped from 2002 to 2007

LACTOPEROXYDASE: a product with high potential An enzym extracted from milk

Lactoperoxidase A milk enzyme Antimicrobial activities against bacteria, viruses and yeasts. Part of the lactoperoxidase system (Many applications are possible). 11

Mean % of sporulating surface of leaves Lactoperoxidase System Enzyme : Lactoperoxidase Substrates H 2 O 2 + SCN - Applications: - Food preservation Lactoperoxydase Product of the réaction OSCN - Antimicrobial, antiviral, antiyeast, anti fungi agent, - Pre-Harvest crops (Research program with Gembloux University) 100 80 60 40 20 First trial 0 H2O 1/5 SM

TARADON laboratory s.p.r.l.

TARADON Lab - Research & Development programs & Patents Research Program : - Use of Lactoperoxidase System for decontamination of the pre-harvest crops. (subsidized by DGO6 - WR) - Industrial production of the Glucose Oxydase (subsidized by DGO6 - WR) - Anti-tumoral activity of lactoferrin Lille University - In vivo study of a combination LP System / LF Cystic Fibrosis Patents: 1) Quality of the lactoferrin LF-NFQ 2) Antibacterial activity of OSCN-/OI- 3) Synergie OSCN-/LF for the cystic fibrosis problems 4) Synergie LPSystem LF on the biofilms bacteria

Our business: Extraction of bio-active ingredients from Milk

TARADON Lab - Managing Director 35 years of experience with these molecules High level of flexibility: We can meet your needs

For further information? Dr Jean-Paul Perraudin Taradon Laboratory S.P.R.L. Avenue Léon Champagne, 2 1480 Tubize Belgium E-mail: jp.perraudin@taradon-laboratory.com http://www.taradon-laboratory.com TEL : +32-495.51.90.64 FAX : +32-390.93.86