126 Graduate School for Health Research SHARE Self evaluation 2003-2008

126 Graduate School for Health Research SHARE Self evaluation 2003-2008

127 Evidence-Based Medicine in Practice 5

128 Graduate School for Health Research SHARE Self evaluation 2003-2008 1 Object i ve s a n d re s e a rch area Evidence-Based Medicine in Practice (EBM-P) concerns research bridging the gap between evidence and clinical practice in health care. This is done by adding evidence from observational studies to the body of knowledge provided by RCTs. Evidence in medicine is mainly derived from randomized clinical trials (RCT). Specific groups (children, pregnant women and the elderly) are generally excluded in RCTs. Moreover, in daily practice, patients have multiple disorders, come from different social and economic situations, and do not always follow the health care professionals recommendations. Evidence on actual practice, therefore, should preferably be verified or obtained from population-based cohort studies, which form the core of the current research activities of the EBM program. Information on the economic impact of changes and innovations in health care provide the necessary input on the feasibility of uptake of these changes in actual health care. Finally, findings on important improvements in health care often find their way too slowly to actual practice because of barriers in the organization of care, the health care provider or inadequate strategies for change. Implementation research adds this type of knowledge and forms the third pillar in bridging the gap between evidence and practice. The mission statement of the EBM-P research program is therefore to provide evidence for clinical practice based on epidemiological studies, economic evaluations and implementation research. A second mission of the program is to be the expertise center for support and improved methodology and quality of clinical research in the UMCG and related primary care settings (general practitioners and community pharmacists). Consultations and research facilities such as database development and data management are being provided for research. Up to 2005 our principal goal was to evaluate and understand primary care performance in terms of quality of care, to develop tools to support optimal care, and improve the implementation of scientific evidence in clinical practice with emphasis on pharmacotherapy. The program was evaluated as very good by the previous review committee, but there was concern about the sustainability. Inclusion of epidemiology, and health / pharmacoeconomics provides the necessary strengthening of the field. It brings together methodological expertise and theoretical knowledge important to advance evidence-based medicine in practice. Therefore the program was extended with three epidemiological groups in 2006. With this extension and the shift of the UMCG focus to healthy ageing, the focus of the program also shifted. Risk factors and predictors of age-related diseases became the major topics, together with their application in effective and cost-effective prevention. The emphasis is still on pharmacotherapy of multifactorial diseases (cardio-metabolic diseases / psychiatry / cancer), factors related to adverse pregnancy outcomes and the effectiveness of prevention measures (screening, vaccines). Pharmacotherapy is the most widely used treatment in clinical care, emphasizing the relevance of pharmacotherapy in everyday practice. The cohorts on which much of our research is based include both disease-based cohorts (notably diabetes), patient-based cohorts (notably pharmacy databases), and population-based cohorts (notably LifeLines).

Chapter 5 Evidence Based Medicine in Practice 129 The research areas of the program consist of three closely related themes: Epidemiology Pharmaceutical care Medical technology assessment (MTA) It is important to realize that these areas cross the borders of the four (initially five) departments participating in the program: Epidemiology (UMCG), Clinical Pharmacology (UMCG), Pharmaco-epidemiology & Pharmaco-economics (University of Groningen), Pharmacotherapy & Pharmaceutical Care (University of Groningen), and, previously, General Practice (UMCG). In line with the suggestions of the previous review committee, the program utilizes large-scale regional databases, either managed by researchers of the program or in close collaboration with other research groups (see facilities in section 5). The existing collaborative projects between the four departments form the basis for our policy to achieve a coherent multidisciplinary research program. To achieve this, the senior staff of the pertaining departments meet regularly to discuss and synchronize on the important calls for grant proposals. Secondly, we organize monthly research meetings where PhD students as well as senior staff present their work. This strategy has resulted both in improvements in running projects, as well as in new multidisciplinary research proposals. The structural collaboration with clinical groups has been extended, underlining the need for a multidisciplinary approach. The results of collaborative projects have a broader scope and thus will lead to faster implementation of evidence-based clinical practice. This is also achieved by active involvement in (Dutch) healthcare policy bodies, such as the CBG/ EMEA/ NHG (details listed in section 8). Likewise, the staff of the EBM-P program have been able to contribute to EBM in practice at a national level through positions or participation in several national programs (section 7).

130 Graduate School for Health Research SHARE Self evaluation 2003-2008 2 Composition of the re s e a rch program The EBM program has been extended since the last evaluation and now includes the departments of Epidemiology, Clinical Pharmacology, Pharmacoepidemiology & Pharmacoeconomics, as well as Pharmacotherapy. This strengthens the position and sustainability of the program and is in line with the recommendations of the peer review committee in 2003. Over the present evaluation period the Department of General Practice reduced its research activities in EBM, and is no longer part of the research program. The core staff of the program in 2008 consists of six professors and two associate professors The program is coordinated by two persons to assure continuity. Prof FM Haaijer-Ruskamp (Drug Utilization Studies) has been one of the coordinators since 2000, while Prof RP Stolk (Clinical Epidemiology) has been involved as a coordinator since 2006, when the program was extended. The other core staff members are: Prof LTW de Jong-van den Berg, professor of Pharmaco-epidemiology Prof MJ Postma, professor of Pharmaco-epidemiology Prof JRBJ Brouwers, professor of Pharmacotherapy Prof E Buskens, professor of Medical Technology Assessment Dr P Denig, associate professor of Drug Utilization Studies Dr GH de Bock, associate professor of Clinical Epidemiology Dr V Fidler, associate professor of Medical Statistics Table 1 provides a description of research staff. An explanation of the way research fte s are computed is given in chapter 1. Table 1 Research staff 2003 2004 2005 2006 2007 2008 fte n fte n fte n fte n fte n fte n Tenured staff Professor 1.40 4 1.30 5 1.00 4 1.73 7 2.29 7 2.36 7 Associate prof 0.08 2 0.68 2 1.29 5 1.25 4 1.26 4 Assistant prof 1.48 4 1.60 5 1.20 3 1.11 4 0.84 3 1.45 5 Total tenured 2.88 8 2.98 10 2.88 10 4.12 15 4.38 14 5.07 16 Non tenured staff Post doc 0.27 1 0.36 1 0.36 1 2.03 5 PhD 5.18 28 5.67 27 7.50 29 5.45 34 7.50 41 11.42 46 Total staff 8.06 36 8.65 37 10.65 40 9.93 50 12.24 56 18.52 67

Chapter 5 Evidence Based Medicine in Practice 131 Table 2 provides an overview of the various types of PhD students, as well as their progress. Table 2 PhDs, types and progress 2003 2004 2005 2006 2007 2008 n n n n n n Total 28 27 29 34 41 46 Type: AIO, MD/PhD 11 11 11 13 20 23 Bursary 4 4 6 7 7 8 Clinical Ext. funding 1 1 1 1 External 13 11 11 13 13 15 Progress: Graduated 5 8 4 4 5 4 In progress 22 19 25 30 34 42 Stopped 1 2 All groups within the program are active in applying for research grants in the area of evidencebased medicine. The main sources include the programs of the Netherlands Organisation for Health Research and Development (ZonMw) on Prevention and Effectiveness. Every year a number of proposals are submitted, and during the evaluation period a substantial number of grants were received (details are provided in section 6). The second source for funding of personnel to perform studies in evidence-based medicine in practice ranges from national research consortia such as TI Pharma and PREDICCt, charity funds (Collectebusfondsen) for specific diseases, like the Kidney Foundation, to public and private organizations in the healthcare field. In collaboration with clinically based researchers (including primary care) and other research programs within SHARE (for example ICPE), proposals are submitted and granted for translational projects, investigating how to apply the results from basic and epidemiological studies to daily clinical practice. The (limited) resources from the university directly provided for our program are used for PhD projects conducted by two or more groups within the EBM program. This is aimed at further strengthening the interaction between the participating groups. These funds are also used to enable the initial development of innovative approaches that may in later stages be supported by external funds.

132 Graduate School for Health Research SHARE Self evaluation 2003-2008 Table 3 provides the proportion between internal funding ( tenured staff ) and externally obtained resources ( other research input ). An overview of large projects acquired will be presented hereafter in section 6: Earning capacity. Table 3 Funding 2003 2004 2005 2006 2007 2008 % % % % % % Tenured staff 268.920 55 283.460 53 274.032 42 394.892 56 455.060 54 527.984 42 Other research input 218.532 45 252.198 47 379.857 58 314.055 44 384.004 46 724.999 58 Total 487.452 100 535.658 100 653.889 100 708.947 100 839.064 100 1.252.983 100 Finally, international collaboration has been extended the group collaborates in relevant European networks (such as EUROCAT, GENECURE, SAR), and has many research activities in collaboration with research groups abroad (details are provided in section 3). As shown in section 6, the above-mentioned activities have been quite successful in obtaining grants. Most research grants in the Dutch system are based on PhD projects, which has resulted in a sharp increase in the number of PhD students. Within the Dutch system, the vast majority of scientific publications is generated by PhD students, notably in their third and fourth years. Therefore, a crop of publications will follow in the coming years.

Chapter 5 Evidence Based Medicine in Practice 133 3 Re s e a rch env ironment and embedding In line with the recommendations of the previous review committee, international and national collaboration has been extended. Collaboration with research groups in the Netherlands and abroad has been and is being actively promoted. The preferred operationalization is a MSc or PhD project conducted partly at the University of Groningen and partly abroad. This can include a stay abroad, but also a joint appointment. The latter is facilitated by the Ubbo Emmius scholarship program of the University of Groningen. Moreover, the programs staff members participate in international networks. Active efforts to invite (more) guest researchers is on the agenda for the near future. The result is the following long list, showing the broad range of disease areas and expertise in methodology. Inte rn ation al Collab or ation Networks ESAC/ EARSS EU networks, Use of antimicrobials and resistance. Self-medication with antimicrobial agents European Diabetes Epidemiology Group BBMRI (Biobanking and Biomolecular Resources Research Infrastructure), a FP7 project of the EC EUROCAT, European network of 40 birth defect registries Nuffic /Vietnam, Anti-tuberculosis drugs and Hepatitis B cost-effectiveness EU Network Drugs and Driving and International Council on Alcohol, Drugs and Traffic Safety (ICADTS) Pharmaceutical Care Network EMEA, ENCePP, European Network of Centres for Pharmacoepidemiology and Pharmacovigilance World Mental Health Surveys Collaborative international MSc / PhD projects Slone Epidemiology Institute, Boston University, USA Medical Research Council UK and Cambridge University Steno Diabetes Center, Copenhagen, Denmark Institute of Medical Sociology and Social Medicine, Marburg University, Germany Department of International Health, University of Copenhagen, Denmark Department of Epidemiology and Health Promotion, National Public Health Institute, Finland Pharmacoepidemiology, Bath University, UK Bremen University, Germany School of Pharmacy, London, UK Health Protection Agency (HPA), London, UK University of Ghent, Belgium GMaSol Consultancy, Switzerland Base Case Consultancy Germany University of Nottingham, UK Department of Medical Genetics, St Mary s Hospital, Manchester, UK Genetic, Epidemiology Unit, University of Cambridge and The CHEK2 Breast Cancer Case- Control Consortium, UK University of Maryland, School of Pharmacy, Baltimore, USA University of Ulster, Belfast School of Pharmacy, Prague

134 Graduate School for Health Research SHARE Self evaluation 2003-2008 Tianjin Medical University Cancer Institute and Hospital, School of Public Health, Tianjin Medical University, China Department of Community Medicine, University of Hong Kong George Institute for International Health, University of Sydney N a t i o n a l c o l l a b o r a t i o n Radboud University Nijmegen Medical Centre Utrecht University (Pharmacoepidemiology; Julius Center for Patient Oriented Research, Geriatrics, Dept. of Psychiatry) Leiden University Medical Center (Clinical Pharmacy, clinical decision-making) Amsterdam Medical Center (Clinical Pharmacy, Dept of Infectious Diseases) RIVM (National Institute for Public Health and the Environment) TI-Pharma (Top Institute Pharma) Royal Dutch Society for the Advancement of Pharmacy (KNMP) College ter Beoordeling van Geneesmiddelen Medicines Evaluation Board Netherlands Vaccine Institute Netherlands Diabetes Epidemiology Study Group Ephor (Centre for expertise concerning pharmacotherapy for the elderly) G u e s t r e s e a r c h e r s Prof J Zito (Pharmaceutical Health Services Research Dept., University of Maryland, Baltimore, US) Dr M Nauton (Darwin, Australia) Dr SL Jackson (Dept. of Pharmacy, University of Tasmania, Australia) Dr AJ van Hoek (Health Protection Agency, London, UK)

Chapter 5 Evidence Based Medicine in Practice 135 4 Q u a lit y and scientif i c relev a n ce M o s t r e l e v a n t r e s u l t s A core issue in our mission is to provide scientific evidence for clinical practice. The most relevant results on this issue can be seen in the evidence our group has provided for national clinical guidelines. Specifically, through positions on boards of guideline consortia or committees and participation in invitational conferences and other forums, the relevance of accounting for evidence and information on cost-effectiveness, budget impact and potential implementation scenarios was stressed. This in addition to growing national and international consensus is increasingly convincing key stakeholders such as CBO, NHG, Trimbos, CVZ and the Orde van Medisch Specialisten (Association of Medical Specialists) that evidence on efficacy, clinical or otherwise, is insufficient for considered policy decisions. Development and validation of performance / quality indicators for use by both health professionals (quality assessment and improvement) and policymakers (external quality assessment). Cost-effectiveness information that has been used in guidelines. For example a dynamic approach was developed to assess the cost-effectiveness of infectious diseases control with applications to Chlamydia screening and pertussis vaccination, anxiety & depression, Parkinson s disease, heart failure. The identification of risk factors and their adequate treatment. Examples include the successful implementation of the project ZorgVoor.foliumzuur bij kinderwens in Dutch community pharmacies to improve folium acid use to prevent birth defects, and GP factors associated with sub-maximal drugs treatment in diabetes patients. The identification of predictors of suboptimal treatment resulting in new approaches to implement evidence-based medicine in practice. For example, factors that determine the undertreatment of risk factors in patients with type 2 diabetes has been unraveled in order to develop a new approach to counter so-called clinical inertia. In addition to numerous publications in high level scientific journals (see section 5), these achievements have resulted in the participation of members of the program in many national and international committees devoted to increasing evidence-based medicine in daily clinical practice (details in section 7). Key publication s The following selection of publications shows the application of methodological expertise within the EBM program on a wide range of diseases. All publications have authors from different departments within the program, as well as at least one clinician or pharmacist, illustrating the interaction within the program and with clinical practice. Boersma C, Postma MJ, Visser ST, Atthobari J, de Jong PE, de Jong-van den Berg LTW, Gansevoort RT. Baseline albuminuria predicts the efficacy of blood pressure-lowering drugs in preventing cardiovascular events. British Journal of Clinical Pharmacology 2008;65:723-32. Voorham J, Haaijer-Ruskamp FM, Stolk RP, Wolffenbuttel BH, Denig P. Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes. Diabetes Care 2008; 31:501-503. Dolk H, Jentink J, Loane MA, Morris JK, De Jong-van den Berg LTW. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008;71:714-22.

136 Graduate School for Health Research SHARE Self evaluation 2003-2008 Van Roon EN, Flikweert S, Le Comte M, Langendijk PNJ, Kwee-van Zuiderwijk WJM, Smits P, Brouwers JRBJ. Clinical relevance of drug-drug interactions: a structured assessment procedure. Drug Safety 2005;28(11)1131-1139. Vehof J, Postma MJ, Bruggeman R, De Jong-Van Den Berg LT, Van Den Berg PB, Stolk RP, Burger H. Predictors for starting depot administration of risperidone in chronic users of antipsychotics. Journal of Clinical Psychopharmacology 2008;28:625-30. M o s t i m p o r t a n t b o o k s / b o o k chapters Our group has published 24 chapters in books, and has been the editor of two books. The majority of publications in books are in Dutch, a few in English and German. The most relevant are: Dukes MNG, Haaijer-Ruskamp FM, de Jonckheere CP, Rietveld AH, (eds). Drugs and money; prices, affordibility and cost containment. Amsterdam etc, IOS Press, 2003. Buurma H, de Jong-van den Berg LTW, Leufkens HGM, (red). Het geneesmiddel. Maarssen, Elsevier Gezondheidszorg, 2005. New ed. 2009. Haaijer-Ruskamp FM, Andersen M, Vander Stichele R. Prescribing quality indicators. In: Hartzema AG, Tilson HH, Chan KA (eds). Pharmacoepidemiology & therapeutic risk management. Cincinnati, OH, Harvey Whitney Books, 2008: pp. 197-218.

Chapter 5 Evidence Based Medicine in Practice 137 5 Q u a ntit y o f s c i e ntif i c o u t p u t The scientific output of the program can broadly be divided into three categories: publications in peer-reviewed journals, facilities provided for epidemiological and primary care research, and consultancy services to support research by other departments. In contrast to publications (number, impact, etc), facilities and consultancy are more difficult to quantify but are as important to provide high quality study outcomes that result in evidence to guide clinical practice. Publication s tr ateg y The EBM-P program aims to publish its findings in high quality international peer-reviewed journals, while simultaneously reaching the professionals and the general public with publications in national professional journals. The latter is described in section 8, Societal Relevance. The scientific publications in peer-reviewed journals of the program are summarized in the table. We have included publications by the researchers from pharmacoepidemiology, pharmacoeconomics and pharmacotherapy over the entire period, because our collaboration dates from before the formal start of these researchers in our program in 2006. The extension of the program in 2006 with epidemiology and HTA is clearly visible in the numbers. In addition to the increased number of publications, the proportion of papers in high-ranked journals per tenured staff member has also increased. This rise is the result of increased collaboration between members of the group. Another important factor has been the active promoting of a publication strategy of increasing the number of publications in high impact journals within a (S)SCI field, triggered by the comments of the review committee and the general strategy of the UMCG. This includes a more critical policy for submitting papers, with a clear view of the impact factor of the journal. Moreover, active collaboration has been established with international research consortia, as well as individual researchers from other national and international centers, to increase the number of publications. Finally, PhD students (and other researchers if necessary) are trained in scientific writing in English. Since the EBM program focuses on bridging the gap between evidence and practice by using a population-based approach based on common methodological approaches and is not diseasedriven like the ISI fields, publications are in several fields, with an emphasis on cardiometabolic diseases and nephrology. The connections with clinical practice are illustrated by the coverage of topics which represent the current burden of disease in society: Pharmacology & Pharmacy Health Care Sciences & Services Health Policy & Services Endocrinology & Metabolism Geriatrics & Gerontology Cardiovascular System & Cardiology N u m b e r o f p u b l i c a t i o n s Table 4 provides a description of several types of research output. An explanation of the the types distinguished is given in chapter 1. Table 4 also gives the average number of top-30% articles per tenured staff member.

138 Graduate School for Health Research SHARE Self evaluation 2003-2008 Table 4 Output 2003 2004 2005 2006 2007 2008 n % n % n % n % n % n % ISI articles top-30% 18 49 30 54 28 49 60 61 55 57 70 64 other 19 51 26 46 29 51 39 39 42 43 39 36 Total 37 100 56 100 57 100 99 100 97 100 109 100 (top-10%) (8 22) (11 20) (14 25) (30 30) (21 22) (38 35) Other refereed articles 22 41 22 13 14 17 Book chapters 1 9 3 8 3 Books 1 1 PhD theses SHARE theses 5 8 4 5 5 4 Others, (co-)supervised 3 3 2 2 1 # Top-30% articles per 2.5 4.0 3.9 5.8 5.0 5.5 tenured staff member Re s e a r c h f a c i l i t i e s The EBM program offers a number of facilities for epidemiological and primary care research. The emphasis is on collecting and managing (large scale) databases of both population and clinically based populations. These comprise a invaluable tool to perform epidemiological and clinical studies. The EBM program provides both scientists to design, improve and interpret these data, and also technicians to construct and support them. The Trial Coordination Center (TCC) facilitates clinical and other researchers with the design, conduction, analysis and reporting of biomedical research. TCC is an ISO certified organization. Its service operations include project management, protocol writing, data entry, data management, monitoring, statistics, reporting and software development. The GIANTT project (Groningen Initiative to Analyse Type 2 diabetes Treatment) is a regional initiative of health care providers and researchers focusing on the care delivered to ambulant patients with type 2 diabetes mellitus in the north of the Netherlands. The InterAction DataBase (IADB) provides complete prescription data regardless of reimbursement status covering 500,000 patients. The aim is to create a laboratory for research in pharmacoepidemiology, pharmacoeconomics and pharmacy practice management, using prescription data from these pharmacies. EUROCAT birth defect database, covering an approximate total population of half a million births per year. MOC COM is a project at the Family Cancer Clinic and concerns a prospective registration of all patient contacts at this clinic. The aim is to assess the cost-effectiveness of the care provided in an evidence-based way. At the moment a similar project is under construction at the Breast Cancer Clinic.

Chapter 5 Evidence Based Medicine in Practice 139 The LifeLines project is being carried out in a representative sample of 165,000 participants from the northern provinces of the Netherlands. LifeLines will employ a three-generation family design (proband design with relatives). The overall aim is to study universal risk factors and their modifiers for multifactorial diseases. Members of the EBM program are actively involved in the LifeLines project, notably in the scientific committee (chair), data quality, protocol development, data management. The aim of the LifeLines project is to study universal risk factors and their modifiers for multifactorial diseases. LifeLines will employ a three-generation family design (proband design with relatives). For the clinical practice of multifactorial diseases, it is important to understand how similar risk factors relate to multiple diseases, and which modifiers contribute to the development of specific multifactorial diseases, not only at one stage of life but cumulatively over time: the lifeline. During the period of this evaluation, preparations have started to create a large research database based on the medical files of all general practitioners and public pharmacies in the northern part of the Netherlands (Dutch acronym AHON), in collaboration with NHG/ LHV. When completed, this database will contain longitudinal information on more than 1.5 million people. The final measure of scientific output is the effort members of the program put into consultancy services. These involve the methodological support of clinical research, ranging from simple one-off questions (like power calculation, study design, model for costs calculation) to collaborative research proposals or collaborative conducting of a study. A special service is run by the MTA researchers to support researchers who want to submit a proposal to the cost-effectiveness program of the Dutch Organisation for Health Research (ZonMw Doelmatigheid). Training of researchers in the hospital and primary care (notably general practitioners and pharmacists) is an explicit part of the consultancy program. A clear example is the monthly presentation series Help Statistics on various statistical problems, providing handson solutions. Since 2006, there have been around 250 consultations per year performed by the program. In addition, support was provided for almost 25 cost-effectiveness grant proposals per year.

140 Graduate School for Health Research SHARE Self evaluation 2003-2008 Follow-up of patients with breast cancer A s an a s s o c i a t e p r o f e s s o r w i t h i n t h e d i s c i p l i n e g r o u p E p i d e m i o l o g y, Tr u u s ke d e B o c k i s s p e c i a l ize d i n o n c o l o g y a n d h e r m o s t i m p o r t a n t r e s e a r c h a r e a i s b r e a s t c a n c e r. O n e o f h e r c u r r e n t p r o j e c t s f o c u s e s o n f i n d i n g a n o p t i m a l f o l l ow - u p s t r a t e g y f o r p a t i e n t s w i t h b r e a s t c a n c e r. W i t h i n t h i s p r o j e c t, s h e c o l l a b o r a t e s w i t h r e s e a r c h e r We n l i L u, w h o i s a l e c t u r e r a t t h e College o f P u b l i c H e a l t h o f T i a n j i n M e d i c a l U n i ve r s i t y i n C h i n a. She became involved in the project via a Bernoulli scholarship. Over the past four years, the researchers had an intensive cooperation. In the first two years they have been designing a database and collecting follow-up data from medical statuses; Wenli in Tianjin, Truuske in the Netherlands. In addition, Wenli worked on a meta-analysis on the impact of follow-up after breast cancer on survival. In the second two years, Wenli worked on her research in Groningen. The database contains the data of 1000 Chinese and 700 Dutch patients, and Wenli worked on the analysis of both databases. Both researchers are involved in research into the optimal strategy for the follow-up of Chinese and Dutch patients suffering from breast cancer. Baseline data It is estimated that there are 1.15 billion new cases of breast cancer worldwide every year. With regard to this, there is a remarkable difference between Western European countries and China. Where the incidence in Western Europe is roughly 6700 per 100,000 women annually, this figure is roughly 19 per 100,000 women in China. In spite of this low incidence, the absolute number of new cases is high; over 20% of all new cases of breast cancer worldwide are diagnosed in China. Wenli explains that this is mainly due to the size of the population. China has a population of 1.31 billion. In addition, the incidence of breast cancer in China is increasing by 3-4% every year. Another remarkable difference between the Chinese and the Dutch data is the age division. In the Netherlands, the average age at the time of diagnosis is about 58, in China this is 48. Many of the women diagnosed in China are at an advanced stage of the disease. An important explanation for this is the fact that there is no such thing as a national screening program. There are possibilities for screening but the patient nearly always has to pay for this. Often women decide against it. Most of them do not see a doctor until symptoms develop. Wenli adds: It is important to investigate the feasibility of a national screening program in China in the light of the low incidence of breast cancer, the vast population and other socioeconomic aspects.

Chapter 5 Evidence Based Medicine in Practice 141 Treatment and follow-up After the primary treatment, which in China means a total breast amputation in 95% of cases but in the Netherlands only happens in 40% of cases, there are various possible follow-up strategies. The main goal of Wendi s research is to determine the optimal strategy for follow-up after breast cancer. A simulation model will be developed using the data collected in the Netherlands. Recently, Wenli has been examining therapy loyalty to the existing follow-up guidelines in daily practice. The guidelines in Tianjin Hospital state that check-ups should occur every three months during the first two years, every six months from the third to the fifth year and after that annually. In actual practice therapy, loyalty to this guideline turns out to be extremely low; only 4% of the patients undergo all the recommended check-ups during the follow-up period. A slightly higher percentage show up once or twice for a check-up after the initial treatment but then do not follow the guideline schedule. What is the cause of this lack of therapy loyalty? The patients are invited for check-ups but simply do not show up. Wenli distinguishes between a number of possible explanations. First and foremost, there is the Chinese insurance system. Many women have to pay for the check-ups themselves. Furthermore, the long distances to the hospital and the additional time and travel expenses may play a role. In addition, researchers think that women may not consider the check-ups that important. If you look at the reported number of local recurrences (return of the cancer), only 4% in ten years, this is understandable. Continuation The development of a simulation model to realize optimal follow-up for women with breast cancer was an interesting and challenging prospect for the researchers. The research and its international character is very inspiring. Recently, Wenli returned to China. She published three articles in the last two years and she has one submitted manuscript. Now she is working on the last two papers and her thesis. The defense of her thesis is expected to be in March 2010. In April 2010, the researchers plan to meet again to work on a new project in which the simulation model will be validated in the Chinese population to contribute to optimal cancer screening in China.

142 Graduate School for Health Research SHARE Self evaluation 2003-2008 6 E a r n ing capacit y Within the Dutch system, the vast majority of scientific publications is generated by PhD students. Therefore, a large proportion of grant proposals are PhD projects, which results in scientific publications three and four years after commencement. As shown in the table in section 2, over the last years the program has been quite successful in obtaining grants for PhD projects, which has resulted in a steep increase in the number of PhD students. The crop of publications will follow in the coming years. F u n d - r a i s i n g s t r a t e g y Below is an overview of the major research grants obtained by the program over the last five years. It is clear that the program has been very successful in obtaining grants from both national and international sources. The wide range of topics illustrates the fruitful application of common methodology in different diseases, with an emphasis on pregnancy, cardiometabolic diseases and nephrology. The program staff aims to be represented on the funding committees of important funds in order to anticipate (new) funding trends, leading to representation on ZonMw committees and relevant societal bodies (CVZ, CBG). Table 5 provides a list of the major research projects (> 100.000,-), classified by funder. Table 5 Major projects acquired European Committee Driving under the influence of medicinal drugs Guidelines pertaining to psychotropic medicines and driving: dissemination and evaluation The economics of genetic and genomic strategies developed in renal diseases by the GENECURE project Selfmedication with antibiotics Building a knowledge repository for occupational well-being economics research HIS-Screen: Cost-effectiveness of genetic screening strategies Other International funds Therapeutic drug monitoring of antituberculosis agents in Vietnam (Nuffic) Cost-of-illness of Hepatitis B disease and cost-effectiveness of Hepatitis B vaccination in Vietnam (Nuffic) NWO LifeLines DNA Bank: A genomics infrastructure for a population-based cohort of 165,000 individuals ZonMw (National Organisation for Health Research and Development) Pharmacy Coordinated ADE Reducing Efforts For Use in all Levels of Healthcare (CAREFUL) Identifying bottle-necks in integrated care (KNOTs) Effect of computerized decision support on medication safety in hospitals Value of Information Discounting in economic evaluations of drugs Comparison of low-flux hemodialysis and hemofiltration (CONTRAST) Manipulative therapy for shoulder complaints in General Practice

Chapter 5 Evidence Based Medicine in Practice 143 Symptoms of collapse in general practice: The effect of pelvis physical therapy and of a pessary A randomized clinical trial of urinary incontinence in older women: Cost-effectiveness of protocolized assessment and evidence-based treatment National program network for the elderly Prevention of psychosocial problems in the offspring of mothers with symptoms of depression or anxiety during pregnancy: Benefits for mother and child TI Pharma (Top Institute Pharma Research) Connecting BIOMARKERS and proxy-outcomes across different phases of drug development (TI-Pharma Esscher) Scientific and societal drivers of the current drug regulatory environment, perspectives for improvement (TI-Pharma Esscher) Improving patient SAFETY through better risk management (TI-Pharma Esscher) The Dutch health care landscape as a population laboratory (TI-Pharma Mondriaan) CTMM (Center for Translational Molecular Medicine) Biomarkers for the Prediction and Early Diagnosis of Diabetes and Diabetes-related Cardiovascular Complications (PREDICCt) WP7: Validation of Biomarkers Biomarkers for the Prediction and Early Diagnosis of Heart Failure (TRIUMPH) WP 9: Medical Technology Assessment Other national funds Costs and effects of screening for micro-albuminuria (Dutch Kidney Foundation) Costs and effects of screening for macro-albuminuria (Dutch Kidney Foundation) Health economics of blood transfusion safety (Landsteiner Foundation) Communicating risk effectively (CORE) study (CBG Medicines Evaluation Board) Doctors information needs and decision support for drug therapy (CVZ - Health Care Insurance Board) Evaluation and implementation of guidelines on antimicrobial therapy (CVZ - Health Care Insurance Board) Pharmaceutical care practice redesign: Health management aspect and business administration (Royal Dutch Society for the Advancement of Pharmacy, KNMP) The role of physical activity, fitness and personality in development of metabolic risk factors (HanzeUniversity Groningen) Integrated Pharmaceutical care (Royal Dutch Society for the Advancement of Pharmacy, KNMP) Revealing the genetic roots of obesity and type 2 diabetes (Senter Novem / Ministry of Economic Affairs) Drug treatment of diabetes, GIANTT baseline measurement (Menzis, Healthcare Insurer) GIANTT Benchmarking diabetes care in Groningen province (GHC, Groningen General Practice Collective) Cost-effective approaches in avoiding blood transfusion (Ministry of Health) Cost-effectiveness of new vaccinations within the National Program 1, 2 and 3 (Netherland Vaccine Institute) Cost-effectiveness of screening strategies for HIV and Chlamydia (SOA / AIDS foundation) Routine Outcome Assessment for detection and treatment of comorbidities among patients with schizophrenia (Public Mental Health, Drenthe)

144 Graduate School for Health Research SHARE Self evaluation 2003-2008 Pharmaceutical industry Cost-effectiveness of fungal infection prevention (ORTHO Biotech UK) Discounting in cost-effectiveness of vaccines (GSK Bio Rixensart Belgium) Cost-effectiveness analysis of HPV-vaccination (GSK Zeist) Costing of influenza epidemics and dynamic modeling of influenza spread (Sanofi) Cost-effectiveness of pneumococcal vaccination (Wyeth) Cost-effectiveness of antihypertensive treatments (Various companies) Cost-effectiveness of prevention and pharmacotherapy for infectious diseases (GlaxoSmithKline) Research on computer-assisted diabetes risk management (Roche Diagnostics) RUG / UMCG Chronic heart failure, adherence to treatment guidelines and quality of life The consumption of non-prescribed antibiotics in Europe in relation to antimicrobial resistence patterns Can national differences in heart-failure treatment be explained by health system features? Antiepileptics during pregnancy The implications of health preferences and quality of life for prevention and care in elderly Lifestyle, the metabolic syndrome and renal disease Predictive value of quality indicators for diabetes care on patients outcomes Statistical approaches to life course epidemiology Measuring quality of cardiovascular risk management, development and testing of valid and meaningful tools for the doctor Improving cardiovascular risk management in patients with diabetes mellitus using risk information from Electronic Patient Records Drug safety in chronic psychiatric patients Predictive value of quality indicators for diabetes care on patients outcomes Pregnancy and disease modifying anti-rheumatic drugs Improving prescribing and usage of gastroprotective drugs in general practice Identifying organizational barriers and resolutions in thrombolytic therapy for acute ischemic stroke in the North of the Netherlands Communication in the family cancer clinic Cost-effectiveness of periodic mammographic screening of asymptomatic women with elevated risk of breast cancer

Chapter 5 Evidence Based Medicine in Practice 145 7 Ac a d e m i c reput ation Members of the EBM program have been recognized for their scientific achievements in different ways. In the overview below the most relevant scientific signs of recognition are given. A major effort is invested in national organizations, in particular ZonMw, the National Organisation for Health Research and Development which focuses on health services research, as well as the Gezondheidsraad (Health Council of the Netherlands), the independent scientific advisory body whose task it is to advise government and Parliament in the field of public health. Both organizations are well in line with the aim of the EBM-P program with its focus on providing evidence for clinical practice. Besides these scientific committees our research group is highly visible in committees on clinical guidelines and healthcare organizations, as described in section 8 (societal relevance). P r ize s a n d aw a r d s A special award was the Medication Safety Award in 2009 which was given by the NVZA (Dutch Society of Hospital Pharmacists) to J. van Doormaal (PhD student) for her work on the effect of a computerised medication ordering system (CPOE) on medication errors and adverse drug events in hospital. She showed that such a system may prevent medication errors, but not directly adverse drug events. Best podium presentation C Boersma (PhD student), International Society of Pharmacoeconomics and Outcome Research (ISPOR) Best poster Renee Lub (reseracher), International Society of Pharmacoepidemiology (ISPE) 2006 Best poster presentation Willeke Kasje (PhD student), International Society of Pharmacoepidemiology (ISPE) 2004 Best poster presentation M van Hulst (PhD student), International Society of Pharmacoeconomics and Outcome Research (ISPOR) 2007 I nv i t a t i o n s f o r m a j o r l e c t u r e s and conference pre s e n t a t i o n s The program staff held a large number of invited lectures. We have selected a limited number of relevent, representative examples of the senior program staff during 2003-2008 LTW de Jong van den Berg, 14 invited lectures, including: Patterns of prescription drug use in pregnancy, ICBDSR, Malta, 18-09-2005 Reproductive Pharmacovigilance, ToulouseCongres de Physiologie, de Pharmacologie et de Therapeutique (P2T), 11-04-2007 M Postma, 40 invited lectures, including: Cost-effectiveness of Enhanced Blood Donor Recruitment and Extended Viral Screening Policies, CDC/PEPFAR Workshop, Washington, Jan 2006 Future of Pharmacogenetics & -economics, European Society for Clinical Pharmacy (ESCP), Oct 2005 E Buskens Invitational conference youth care on use and usefulness of TA Invitational conference on use and design of TA in elderly care (NPO) P Denig Second national Medication Compliance conference, 2008

146 Graduate School for Health Research SHARE Self evaluation 2003-2008 H Burger World Mental Health Survey Initiative Conference, Portsmouth, New Hampshire, United States, 2007 C o n f e r e n c e o r g a n izational a c t i v i t i e s FM Haaijer Ruskamp Workshop on Prescribing Quality Indicators, DURQUIM - Mechelen 2004 Sharing knowledge better (Kennis beter delen), ZonMw Second National Conference on implementation in Health Care 2002 and again in 2004 RP Stolk Overweight in young children: research and clinical practice, March 29 and 30 2007 Third advanced diabetes epidemiology course, March 20-24, 2004 Fourth advanced diabetes epidemiology course, February 25-27, 2009 LTW de Jong van den Berg Board of directors International Society of Pharmacepidemiology (ISPE) (two terms 2006-2009 and 2009-2011) Initiator and Chair of the special interest group Medication in Pregnancy, International Society of Pharmacepidemiology (ISPE) M Postma Board of Presidents of the European Public Health Association (EUPHA) Conference 2006-2009. President of the section Public Health economics, organising annual workshops E Buskens CTMM (Center for Translational Molecular Medicine) Board - Working Conference on Economic Evaluation and Valorisation E ditorships FM Haaijer Ruskamp Editorial Board BMC Family Practice Editorial Board Geneesmiddelenbulletin RP Stolk Member Editorial Board HealthDirect Diabetes Member Editorial Board Primary Care Diabetes Member Editorial Board Polish Archives of Internal Medicine Associate Editor European Journal of Epidemiology LTW de Jong van den Berg European Journal Clinical Pharmacology Pharmacy World and Science Education in Pharmacy Journal of Pharmacy Practic International Journal of Risk and Safety in Medicine Chair Editorial Board Geneesmiddelenbulletin

Chapter 5 Evidence Based Medicine in Practice 147 M Postma Editorial Board Expert Reviews in Pharmacoeconomics & Outcomes Research Editorial Board Expert Reviews in Clinical Pharmacology Editorial Board of the Open Pharmacoeconomics Journal Editorial Board (Vice president) of the Scientific Issues of Pharmaceutisch Weekblad (in Dutch) E Buskens Editorial Board Stroke M e m b e r s h i p o f a c a d e m i e s a n d committees FM Haaijer Ruskamp Member Health Council Member Health Council Committee Primary health care Member Health Council Committee Risc of doping in amateur sports ZonMw Working Group Effective Implementation ZonMw Working Group Scientific Quality of Health Services Research ZonMw Prevention Program, subcommittee Implementation Research and pilot implementation projects ZonMw Committee Expensive Medicines ZonMw Committee Priority Medicines of Elderly and Children LTW de Jong van den Berg Member Health Council Committee Preconception Care: A good start NWO (ZonMw) VIDI-committee M Postma Member Health Council E Buskens ZonMw Costs and Effets, sub program committee Early Evaluation of Medical Innovation ZonMw committee KKCZ (Kennisbeleid Kwaliteit Curatieve Zorg) Knowledge policy Quality Curative Care) GH de Bock Member Health Council Committee Population based reserach Intestinal cancer Member Health Council Committee Monitoring after cancer H Groen ZonMw Prevention Subprogram Effectiveness and Cost Effectiveness O t h e r P r o o f s o f Q u a l i t y Visiting Professorships M Postma: Health Protection Agency (part-time) (2008) LTW de Jong van den Berg: Ulster University (2009 2013)

148 Graduate School for Health Research SHARE Self evaluation 2003-2008 8 Societal Re l ev a n ce G e n e r a l The focus of the research program is on enabling the implementation of scientific knowledge in actual practice. This is done in a variety of ways, for example by looking at the costs of implementing new treatments in actual practice, by developing and testing tools to improve clinical practice and providing population-based knowledge. The results of the research of the program are used in clinical guidelines, in decision-making on drug registration and reimbursement, on developing prescription indicators, quality improvement projects, etc. To achieve this, the program participants are involved in a variety of organizations ranging from policymakers to health care providers and patients. In view of our mission it is clear that the focus is on public healthcare. By publishing in Dutch journals, information is made more accessible to Dutch health care providers. Ad v i s o r y c o m m i t t e e s a n d c o u r s e s FM Haaijer Ruskamp Chair of the committee for Research in Medicine of the Health Care Insurance Board (Dutch: CvZ College voor Zorgverzekeringen) RP Stolk NL de maat (NL the measure). A national study of the health and lifestyle of a truely representative sample of the Netherlands population. National Institute for Health and the Environment, Bilthoven Van gegevens verzekerd (Securing the data supply). The availability of population health information in the Netherlands, now and in the future. Advisory Council on Health Research, The Hague Publieksacademie: Diabetes & overweight. Part of the Publieksacademie, a series of lectures, newspaper articles and a book on common health problems for the inhabitants of the city of Groningen LTW de Jong van den Berg Member of the Expert Group Pharmacovigilance (CBG- Medication Evaluation Board) PAO courses for hospital and other pharmacists courses 2-3 times per year Implementing evidence on advantages of folic acid in practice. Development and implementation of the project: Care for folic acid in collaboration with Mediclara in Dutch Pharmacies M Postma Member of the CvZ-committee Pharmaceutical Assistance Member of the Strategic Platform (discussion platform on expensive drugs) PAO course PharmacoEconomics Annual: course Cost-effectiveness Analysis in Master Class Vaccinology Annual: course Cost-effectiveness Analysis in NSPOH E Buskens Chair of the Board Dutch Society for Technology Assessment in Health Care Boardmember of the ZonMw-committee for research into the Quality of Curative Care KKCZ board en 3 richtlijnen (+ recentere richtlijnen start 2008) Implementatie commissie Proeftuin Farmaceutische Zorg Groningen 2004-2007 GIANTT/GHC: independent third party and advisor for benchmarking diabetes treatment in primary care in the Groningen region (around 200 GPs)

Chapter 5 Evidence Based Medicine in Practice 149 JRBJ Brouwers LAREB, Dutch Institute for Pharmacovigilance EPHOR director Expertise Centre for Pharmacotherapy in Elderly WINAP (advisory board Dutch Institute for Pharmacy Practice Research) P Denig Invited expert for Preprogram committee for Medication Adherence 2008 Member national DGV-working group for prescription feedback 2003-2007 H Burger Member of the Committee on Regulation of Research (in Dutch: COREON) of the Dutch Federation of Biomedical Scientific Societies (FMWV) and the Netherlands Epidemiology Society (VvE) Twice a year: course Evidence Based Medicine for medical specialists in training (Wenckebach DOC program) GH de Bock Member of the VIKC-committee: Follow-up and standardization of care for cancer patients. (VIKC: Association of Comprehensive Cancer Centers, Dutch: Vereniging van Integrale Kanker Centra) Member of the NHG working group Mammacarcinoom revision. 2007-2008 (NHG: Netherlands Association for GPs; Dutch: Nederlands Huisartsen Genootschap) Member of the CBO working group Mammacarcinoom, guideline for treatment and follow-up. 2005-2007. (CBO: Quality Institute for Health Care, Dutch: Kwaliteitsinstituut voor de Gezondheidszorg) Member of the NHG working group Sinusitis. Revision. 2004-2005 Twice a year: course Evidence Based Medicine for medical specialists in training (Wenckebach DOC program) H Groen Scientific Advisory Committee Consortium Studies Obstetry, Fertility and Gynecology Misce llane ous GIANTT/GHC: independent third party and advisor for benchmarking diabetes treatment in primary care in the Groningen region (around 200 GPs) AHON: Academic General Practice Network. Over the last years a collaboration has been established between the UMCG and the National Dutch GP organizations to create an infrastructure to make the data from the GP medical files available for scientific research. This network is an extension of the existing collaboration in the UMCG between researchers and GPs in the provinces of Groningen, Friesland and Drenthe, like the RNG and GIANTT projects. Eventually AHON will include the anonymized GP medical data from about 1.5 million people which can be used by the GPs for benchmark and performance indicators, and by UMCG investigators to perform scientific research. AHON will be included in the Mondriaan project (Stolk, Postma, and Utrecht University), which enables linkage through a trusted third party with other health data, like the LifeLines population cohort study, hospital discharge diagnoses, etcetera IKNO: Comprehensive Cancer Centre North East is the knowledge and quality centre for oncological care in the northern part of the Netherlands. The scientific studies on evidencebased oncological treatment are performed in close cooperation with the oncological center of the UMCG and the Department of Epidemiology (De Bock).

150 Graduate School for Health Research SHARE Self evaluation 2003-2008 Publication s in D utch Our group has been active in reporting its work to the Dutch healthcare field and have published in Dutch: 74 articles in Dutch scientific journals 61 articles in Dutch professional journals 16 chapters in Dutch professional books and were editors of one Dutch textbook.

Chapter 5 Evidence Based Medicine in Practice 151 9 Vit a lit y and f e a s ibilit y Ev a l u a t i o n o f t h e p r e v i o u s c o m m i t t e e s re c o m m e n d a t i o n s Regional databases As described in the earlier sections, the research group has been successful in creating databases in collaboration with both the direct clinical environment (hospitals, GPs and community pharmacists), as well as with scientific collaborative plans. Researchers are also involved in international databases, such as EUROCAT on birth defects. Sustainability of the research program The program was increased extensively in 2006, after the last peer review. It has shifted its focus more towards epidemiology, and is well embedded in local, national and international research networks. Together with the shift in focus, less effort has been put into theoretical social scientific studies, with the exception of the implementation research. S WOT an alysis The program has expanded considerably in a short period of time. This is of great importance in ensuring the viability of the program, building on the existing strengths of the earlier program. On the other hand, this implies only a relatively short time to build on close collaboration in the program. We have identified several strengths and some potential weaknesses, listed below. Strenghts We are an interdisciplinary group with backgrounds in medicine and pharmacy. The extension of the program with epidemiology, pharmacoepidemiology and medical technology assessment has resulted in wide expertise that covers the whole field of evidence-based medicine and pharmacotherapy in daily clinical care Newly initiated and long-lasting large-scale population-based studies (LifeLines) and databases within the program in both pharmacy (EUROCAT, IADB) and medicine (GIANTT) provide ample opportunities to conduct epidemiological research The bi-directional collaboration with strong clinical departments results in research questions and results directly applicable in clinical care We have elaborated an explicit focus on very specific topics (drug use in pregnancy, pharmacoeconomics, cardiometabolic diseases and nephrology) We are well recognized in the international scientific community, as can be deduced from the many publications being accepted in peer-reviewed journals, various invited lectures, referee tasks and invitations for membership of relevant committees and boards Weaknesses Since the expansion of the program is quite recent, the integration of the EBM-P subgroups is not yet fully realized Lack of research-oriented staff at the Department of General Practice The geographical location of Groningen sometimes complicates cooperation and the possibility to attract highly qualified staff Opportunities The UMCG has chosen Healthy Ageing as central research theme, which is in line with existing research interests and experience in the EBM-P group research. The databases managed by the EBM-P group (LifeLines, GIANTT, IADB) provide the opportunities to strengthen our profile in this area

152 Graduate School for Health Research SHARE Self evaluation 2003-2008 Quality assurance programs in the Netherlands, evidence-based guidelines, including costeffectiveness, are promoted by the national Dutch societies. In relation to this, quality indicators are also more widely promoted. Full integration of the subgroups in EBM Building a case-control monitoring system with non-malformed controls in Europe based on the EUROCAT-network that can be used in reproductive pharmacovigilance (EUROmediCAT) Developing a Dutch expertise centre for cost-effectiveness of vaccinations, in close cooperation with the UMCG After the major discoveries in genetics it has now been realized that tailored care has to be based on evidence from clinical data Threats In the current financial crisis resources may be limited and the priority might shift from developing evidence to practical implementation, even in the absence of adequate evidence Recruiting sufficient qualified staff in Groningen, also in view of the recent expansion of the program Other centers may see the same opportunities as we do, notably RIVM regarding the expertise center for vaccinations Further development of our program rests on strengthening the focus on issues relating to healthy ageing based on the available databases, and also on the full integration of the subgroups in EBM. In essence the group is still a young group (since 2006) as it stands now. There is much in common, and, as shown, much has been achieved in the short time since the close collaboration stated. The consultant function is an important asset, but we will guard the focus of the research program.

Chapter 5 Evidence Based Medicine in Practice 153 10 N e x t generation Evidence-Based Medicine is the leading theme of current medical practice, also in the UMCG. As indicated in the mission statement, researchers of the EBM program are actively involved in the promotion of and training in EBM principles. These are both aimed at primary care (general practitioners, community pharmacists), as well as hospital-based physicians and pharmacists. Examples include the EBM module within the UMCG program for specialists in training (Wenckebach DOC, Discipline Overriding Courses ), the annual course in cost-effectiveness analysis in NSPOH (Postma), PAO courses for hospital and other pharmacists (given 2-3 times) and PAO course in Pharmacoeconomics. Regarding training of researchers, staff of the EBM program is heavily involved in numerous teaching programs of the UMCG and University of Groningen. These range from undergraduate training in the basics of statistics and epidemiology to dedicated PhD modules in methods of health research. As indicated in chapter 2 of the self-evaluation report, the program directors of the EBM program supervise the MSc and the PhD education programs of SHARE, respectively. This reflects the active involvement and relevance of the EBM program in the teaching of next generation researchers in the field of health research. Apart from training Groningen researchers, the departments participating in the EBM program are actively involved in training health science researchers from other countries. Notably, PhD projects are actively initiated in the collaboration with foreign universities, typically based on combining data from abroad with expertise from Groningen.

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 267 Re f e r e e d a r t i c l e s i n I S I j o u r n a l s 2 0 0 3 Boendermaker PM, Conradi MH, Schuling J, Meyboom de Jong B, Zwierstra RP, Metz JC. Core characteristics of the competent general practice trainer, a Delphi study. Advances in Health Sciences Education Theory and Practice 2003; 8:111 116. Bos JM, Rumke H, Welte R, Postma MJ. Epidemiologic impact and cost effectiveness of universal infant vaccination with a 7 valent conjugated pneumococcal vaccine in the Netherlands. Clinical Therapeutics 2003; 25:2614 2630. de Jong van den Berg LTW, Tobi H, Bijker B, van den Berg P. Influence of the third generation pill controversy on prescriptions for oral contraceptives among first time users: population based study. British Medical Journal 2003; 326:254. de Jong JCF, van den Berg PB, Tobi H, de Jong van den Berg LTW. Combined use of SSRIs and NSAIDs increases the risk of gastrointestinal adverse effects. British Journal of Clinical Pharmacology 2003; 55:591 595. de Visser CL, Bilo HJ, Thomsen TF, Groenier KH, Meyboom de Jong B. Prediction of coronary heart disease: a comparison between the Copenhagen risk score and the Framingham risk score applied to a Dutch population. Journal of Internal Medicine 2003; 253:553 562. Fijn R, Koorevaar RT, Brouwers JRBJ. Prevention of heterotopic ossification after total hip replacement with NSAIDs. Pharmacy World & Science 2003; 25:138 145. Gerritsen MJ, Berg IJ, Deelman BG, Visser Keizer AC, Meyboom de Jong B. Speed of information processing after unilateral stroke. Journal of Clinical and Experimental Neuropsychology 2003; 25:1 13. Groenier KH, Winters JC, Meyboom de Jong B. Classification of shoulder complaints in general practice by means of nonmetric multidimensional scaling. Archives of Physical Medicine and Rehabilitation 2003; 84:812 817. Hart HE, Redekop WK, Assink JH, Meyboom de Jong B, Bilo HJ. Health related quality of life in patients with newly diagnosed type 1 diabetes. Diabetes Care 2003; 26:1319 1320. Hart HE, Bilo HJ, Redekop WK, Stolk RP, Assink JH, Meyboom de Jong B. Quality of life of patients with type I diabetes mellitus. Quality of Life Research 2003; 12:1089 1097. Klok RM, Postma MJ, van Hout BA, Brouwers JRBJ. Meta analysis: comparing the efficacy of proton pump inhibitors in short term use. Alimentary Pharmacology & Therapeutics 2003; 17:1237 1245. Monster TBM, de Jong PE, de Jong van den Berg LTW. Drug induced renal function impairment: a population based survey. Pharmacoepidemiology and Drug Safety 2003; 12:135 143. Monster TBM, Janssen WMT, de Jong PE, de Jong van den Berg LTW. Corticosteroid use and its association with microalbuminuria in the adult population. Pulmonary Pharmacology & Therapeutics 2003; 16:349 353. Pont LG, van Gilst WH, Lok DJ, Kragten HJ, Haaijer Ruskamp FM. The relevance of heart failure severity for treatment with evidence based pharmacotherapy in general practice. European Journal of Heart Failure 2003; 5:187 193. Pont LG, Sturkenboom MC, van Gilst WH, Denig P, Haaijer Ruskamp FM. Trends in prescribing for heart failure in Dutch primary care from 1996 to 2000. Pharmacoepidemiology and Drug Safety 2003; 12:327 334. Postma MJ, van de Watering LMG, de Vries R, Versmoren D, van Hulst M, Tobi H, van der Poel CL, Brand A. Cost effectiveness of leucocyte depletion of red cell transfusions for patients undergoing cardiac surgery. Vox Sanguinis 2003; 84:65 67. Postma MJ. Pharmacoeconomic research. Pharmacy World & Science 2003; 25:245 246. Postma MJ, Beck EJ, Sprenger HG, de Jong van den Berg LTW. The economic profile of antenatal HIV testing: pharmaceutical and methodological considerations. Aids 2003; 17:755 757. Rijcken CAW, Monster TBM, Brouwers JRBJ, de Jong van den Berg LTW. Chlorpromazine equivalents versus defined daily doses: How to compare antipsychotic drug doses? Journal of Clinical Psychopharmacology 2003; 23:657 659. top-10% article top-30% article

268 Graduate School for Health Research SHARE Self evaluation 2003-2008 Rijcken CAW, Boelema GJ, Slooff CJ, Beuger PJ, Tanja TA, de Jong van den Berg LTW. Off label use of antipsychotics in the community pharmacy: The sex differences. Pharmacopsychiatry 2003; 36:187 191. Schaafsma ES, Raynor TDK, de Jong van den Berg LTW. Accessing medication information by ethnic minorities: barriers and possible solutions. Pharmacy World & Science 2003; 25:185 190. Schirm E, Tobi H, de Jong van den Berg LTW. Risk factors for unlicensed and off label drug use in children outside the hospital. Pediatrics 2003; 111:291 295. Schirm E, Tobi H, de Vries TW, Choonara I, de Jong van den Berg LTW. Lack of appropriate formulations of medicines for children in the community. Acta Paediatrica 2003; 92:1486 1489. Stewart RE, Vroegop S, Kamps GB, van der Werf GT, Meyboom de Jong B. Factors influencing adherence to guidelines in general practice. International Journal of Technology Assessment in Health Care 2003; 19:546 554. Ubink Veltmaat LJ, Bilo HJ, Groenier KH, Houweling ST, Rischen RO, Meyboom de Jong B. Prevalence, incidence and mortality of type 2 diabetes mellitus revisited: a prospective population based study in The Netherlands (ZODIAC 1). European Journal of Epidemiology 2003; 18:793 800. van der Pal de Bruin K, de Walle HEK, de Rover CM, Jeeninga W, Cornel MC, de Jong van den Berg LTW, Buitendijk SE, Paulussen TGWM. Influence of educational level on determinants of folic acid use. Paediatric and Perinatal Epidemiology 2003; 17:256 263. van Dijk KN, Pont LG, de Vries CS, Franken M, Brouwers JR, de Jong van den Berg LT. Prescribing indicators for evaluating drug use in nursing homes. Annals of Pharmacotherapy 2003; 37:1136 1141. van Grootheest AC, Groote JK, de Jong van den Berg LTW. Intensive monitoring of new drugs based on first prescription signals from pharmacists: a pilot study. Pharmacoepidemiology and Drug Safety 2003; 12:475 481. van Grootheest K, de Graaf L, de Jong van den Berg LTW. Consumer adverse drug reaction reporting A new step in pharmacovigilance? Drug Safety 2003; 26:211 217. van Hout BA, Klok RM, Brouwers JRBJ, Postma MJ. A pharmacoeconomic comparison of the efficacy and costs of pantoprazole and omeprazole for the treatment of peptic ulcer or gastroesophageal reflux disease in the Netherlands. Clinical Therapeutics 2003; 25:635 646. van Hulst M, de Wolf JTM, Postma MJ. Author s reply: Solvent detergent treated plasma: clinical evidence prior to economics. Vox Sanguinis 2003; 84:334 335. Verhave JC, Hillege HL, Burgerhof JG, Navis G, de Zeeuw D, de Jong PE. Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women. Journal of the American Society of Nephrology 2003; 14:1330 1335. Visser Keizer AC, Meyboom de Jong B, Deelman BG, Berg IJ, Gerritsen MJJ. Subjective changes in emotion, cognition and behaviour after stroke: factors affecting the perception of patients and partners. Journal of Clinical and Experimental Neuropsychology 2003; 24:1032 1045. Weeber M, Vos R, Klein H, de Jong van den Berg LTW, Aronson AR, Molema G. Generating hypotheses by discovering implicit associations in the literature: A case report of a search for new potential therapeutic uses for thalidomide. Journal of the American Medical Informatics Association 2003; 10:252 259. Welte R, Kretzschmar M, van den Hoek JAR, Postma MJ. A population based dynamic approach for estimating the cost effectiveness of screening for Chlamydia trachomatis. Sexually Transmitted Infections 2003; 79:426. Wieringa NF, Peschar JL, Denig P, de Graeff PA, Vos R. Connecting pre marketing clinical research and medical practice: opinion based study of core issues and possible changes in drug regulation. International Journal of Technology Assessment in Health Care 2003; 19:202 219. Zaidi STR, Hassan Y, Postma MJ, Ng SH. Impact of pharmacist recommendations on the cost of drug therapy in ICU patients at a Malaysian hospital. Pharmacy World & Science 2003; 25:299 302. 2 0 0 4 Atthobari J, Monster TBM, de Jong PE, de Jong van den Berg LTW. The effect of hypertension and hypercholesterolemia screening with subsequent intervention letter on the use of blood pressure and lipid lowering drugs. British Journal of Clinical Pharmacology 2004; 57:328 336. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 269 Baarveld F. Recidivism in sports related injuries in primary care. British Journal of Sports Medicine 2004; 38:642 643. Bell CF, Botteman MF, Gao X, Weissfeld JL, Postma MJ, Pashos CL, Triulzi D, Staginnus U. Cost effectiveness of transfusion of platelet components prepared with pathogen inactivation treatment in the United States. Clinical Therapeutics 2004; 25:2464 2486. Bemelmans WJ, Lefrandt JD, Feskens EJ, van Haelst PL, Broer J, Meyboom de Jong B, May JF, Cohen Tervaert JW, Smit AJ. Increased alpha linolenic acid intake lowers C reactive protein, but has no effect on markers of atherosclerosis. European Journal of Clinical Nutrition 2004; 58:1083 1089. Bemelmans WJE, Broer J, Hulshof KFAM, Siero FW, May JF, Meyboom de Jong B. Long term effects of nutritional group education for persons at high cardiovascular risk. European Journal of Public Health 2004; 14:240 245. Bergman GJD, Winters JC, Groenier KH, Pool JJM, Meyboom de Jong B, Postema K, van der Heijden GJMG. Manipulative therapy in addition to usual medical care for patients with shoulder dysfunction and pain A randomized, controlled trial. Annals of Internal Medicine 2004; 141:432 439. Bos JM, Beutels P, Annemans L, Postma MJ. Valuing prevention through economic evaluation Some considerations regarding the choice of discount model for health effects with focus on infectious diseases. Pharmacoeconomics 2004; 22:1171 1179. de Vries TW, de Jong van den Berg LTW, Hadders Algra M. Paroxetine during lactation: is it really safe for the infant? Acta Paediatrica 2004; 93:1406 1407. Deneer VHM, Lie AH, Kingma JH, Proost JH, Gossen SA, Stuurman A, UytdeHaag GMM, Dunselman PHJM, Brouwers JRBJ. Absorption kinetics and pharmacodynamics of two oral dosage forms of flecainide in patients with an episode of paroxysmal atrial fibrillation. European Journal of Clinical Pharmacology 2004; 60:693 701. Deneer VHM, Borgh MBI, Kingma JH, Lie AH, Brouwers JRBJ. Oral antiarrhythmic drugs in converting recent onset atrial fibrillation. Pharmacy World & Science 2004; 26:66 78. Gansevoort RT, de Jong PE, Postma M. Cost effectiveness of screening for proteinuria. Jama Journal of the American Medical Association 2004; 291:1442 1443. Greving JP, Denig P, van der Veen WJ, Beltman FW, Sturkenboom MC, de Zeeuw D, Haaijer Ruskamp FM. Does comorbidity explain trends in prescribing of newer antihypertensive agents? Journal of Hypertension 2004; 22:2209 2215. Groenier KH, de Winter AF, Winters JC, De Vet HCW, Meyboom de Jong B. Complaint severity and cervical spine problems successfully classified patients with shoulder complaints. Journal of Clinical Epidemiology 2004; 57:730 736. Jansen TLTA, Reinders MK, van Roon EN, Brouwers JRBJ. Benzbromarone withdrawn from the European market: Another case of absence of evidence is evidence of absence? Clinical and Experimental Rheumatology 2004; 22:651. Jansman FGA, Postma MJ, van Hartskamp D, Willemse PHB, Brouwers JRBJ. Cost benefit analysis of capecitabine versus 5 fluorouracil/leucovorin in the treatment of colorectal cancer in the Netherlands. Clinical Therapeutics 2004; 26:579 589. Kasje WN, Denig P, de Graeff PA, Haaijer Ruskamp FM. Physicians views on joint treatment guidelines for primary and secondary care. International Journal for Quality in Health Care 2004; 16:229 236. Klok RM, van der Veen WJ, van der Werf GT, van den Berg PB, Brouwers JR, Postma MJ. Pharmacoeconomics of gastrointestinal drug utilisation prior and post Helicobacter pylori eradication. Helicobacter 2004; 9:87 91. Knijff Dutmer EAJ, Postma MJ, van der Palen J, Brouwers JRBJ, van de Laar MAFJ. Incremental cost effectiveness of cyclooxygenase 2 selective versus nonselective nonsteroidal, anti inflammatory drugs in a cohort of coumarin users: A pharmacoeconomic analysis linked to a case control study. Clinical Therapeutics 2004; 26:1160 1167. Krol N, Wensing M, Haaijer Ruskamp F, Muris JWM, Numans ME, Schattenberg G, van Balen J, Grol R. Patient directed strategy to reduce prescribing for patients with dyspepsia in general practice: a randomized trial. Alimentary Pharmacology & Therapeutics 2004; 19:917 922. top-10% article top-30% article

270 Graduate School for Health Research SHARE Self evaluation 2003-2008 Mol PGM, Rutten WJMJ, Gans ROB, Degener JE, Haaijer Ruskamp FM. Adherence barriers to antimicrobial treatment guidelines in teaching hospital, the Netherlands. Emerging Infectious Diseases 2004; 10:522 525. Mookhoek EJ, Loonen AJM. Retrospective evaluation of the effect of omeprazole on clozapine metabolism. Pharmacy World & Science 2004; 26:180 182. Movig KLL, Mathijssen MPM, Nagel PHA, van Egmond T, de Gier JJ, Leufkens HGM, Egberts ACG. Psychoactive substance use and the risk of motor vehicle accidents. Accident Analysis and Prevention 2004; 36:631 636. Pont L, Denig P, van der Molen T, van der Veen W, Haaijer Ruskamp F. Validity of performance indicators for assessing prescribing quality: The case of asthma. European Journal of Clinical Pharmacology 2004; 59:833 840. Pont LG, van der Molen T, Denig P, van der Werf GT, Haaijer Ruskamp FM. Relationship between guideline treatment and health related quality of life in asthma. European Respiratory Journal 2004; 23:718 722. Postma MJ, Bos JM, Beutels P, Schilthuis H, van den Hoek JAR. Pharmaco economic evaluation of targeted hepatitis A vaccination for children of ethnic minorities in Amsterdam (The Netherlands). Vaccine 2004; 22:1862 1867. Rath K, Taxis K, Walz G, Gleiter CH, Li SM, Heide L. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). American Journal of Tropical Medicine and Hygiene 2004; 70:128 132. Rijcken CAW, Tobi H, Vergouwen ACM, de Jong van den Berg LTW. Refill rate of antipsychotic drugs: an easy and inexpensive method to monitor patients compliance by using computerised pharmacy data. Pharmacoepidemiology and Drug Safety 2004; 13:365 370. Schaars CF, Denig P, Kasje WN, Stewart RE, Wolffenbuttel BHR, Haaijer Ruskamp FM. Physician, organizational, and patient factors associated with suboptimal blood pressure mmanagement in Type 2 diabetic patients in primary care. Diabetes Care 2004; 27:123 128. Schirm E, Schwagermann MP, Tobi H, de Jong van den Berg LTW. Drug use during breastfeeding. A survey from the Netherlands. European Journal of Clinical Nutrition 2004; 58:386 390. Schirm E, Meijer WM, Tobi H, de Jong van den Berg LTW. Drug use by pregnant women and comparable non pregnant women in The Netherlands with reference to the Australian classification system. European Journal of Obstetrics Gynecology and Reproductive Biology 2004; 114:182 188. Schirm E, Tobi H, de Jong van den Berg LTW. Identifying parents in pharmacy data: a tool for the continuous monitoring of drug exposure to unborn children. Journal of Clinical Epidemiology 2004; 57:737 741. Schirm E, Monster TBM, de Vries R, van den Berg PB, de Jong van den Berg LTW, Tobi H. How to estimate the population that is covered by community pharmacies? An evaluation of two methods using drug utilisation information. Pharmacoepidemiology and Drug Safety 2004; 13:173 179. Schirm E, Tobi H, van Puijenbroek EP, Monster Simons MH, de Jong van den Berg LTW. Reported adverse drug reactions and their determinants in Dutch children outside the hospital. Pharmacoepidemiology and Drug Safety 2004; 13:159 165. Schirm E, Pedersen L, Tobi H, Nielsen GL, Sorensen HT, de Jong van den Berg LTW. Drug use among fathers around time of conception: two register based surveys from Denmark and The Netherlands. Pharmacoepidemiology and Drug Safety 2004; 13:609 613. Smink BE, Brandsma JE, Dijkhuizen A, Lusthof KJ, de Gier JJ, Egberts ACG, Uges DRA. Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine like substances in whole blood by liquid chromatography (tandem) mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2004; 811:13 20. Stuurman Bieze AGG, van den Berg PB, Tromp TFJ, de Jong van den Berg LTW. Computer assisted medication review for asthmatic patients as a basis for intervention Constructing and validating an algorithmic computer instrument in pharmacy practice. Pharmacy World & Science 2004; 26:289 296. Svensson E, Haaijer Ruskamp FM, Lundborg CS. Self medication with antibiotics in a Swedish general population. Scandinavian Journal of Infectious Diseases 2004; 36:450 452. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 271 Taxis K, Barber N. Incidence and severity of intravenous drug errors in a German hospital. European Journal of Clinical Pharmacology 2004; 59:815 817. Taxis K, Wirtz V, Barber N. Variations in aseptic techniques during preparation and administration of intravenous drugs an observation based study in the UK and in Germany. Journal of Hospital Infection 2004; 56:79 81. Terpstra W, May J, Smit A, de Graeff P, Meyboom de Jong B, Crijns H. Effects of amlodipine and lisinopril on intima media thickness in previously untreated, elderly hypertensive patients (the ELVERA trial). Journal of Hypertension 2004; 22:1309 1316. Tobi H, van den Heuvel NJN, de Jong van den Berg LTW. Does uncollected medication reduce the validity of pharmacy dispensing data? Pharmacoepidemiology and Drug Safety 2004; 13:497 500. Tramarin A, Postma MJ, Gerzeli S, Campostrini S, Starace F. The clinical and economic efficacy of HAART: a shift from inpatient medical to outpatient pharmaceutical care for HIV/AIDS patients in Northeastern Italy. Aids Care Psychological and Socio Medical Aspects of Aids/Hiv 2004; 16:213 218. Tramarin A, Campostrini S, Postma MJ, Calleri G, Tolley K, Parise N, de Lalla F. A multicentre study of patient survival, disability, quality of life and cost of care Among patients with AIDS in northern Italy. Pharmacoeconomics 2004; 22:43 53. Tramarin A, Parise N, Campostrini S, Yin DD, Postma MJ, Lyu R, Grisetti R, Capetti A, Cattelan AM, Di Toro MT, Mastroianni A, Pignattari E, Mondardini V, Calleri G, Raise E, Starace F. Association between diarrhea and quality of life in HIV infected patients receiving highly active antiretroviral therapy. Quality of Life Research 2004; 13:243 250. Ubink Veltmaat LJ, Damoiseaux RA, Rischen RO, Groenier KH. Please, let my doctor be obese: associations between the characteristics of general practitioners and their patients with type 2 diabetes. Diabetes Care 2004; 27:2560. van Bergen JEAM, Postma MJ, Peerbooms PGH, Spangenberg AC, Tjen AT, Bindels PJE. Effectiveness and cost effectiveness of a pharmacy based screening programme for Chlamydia trachomatis in a high risk health centre population in Amsterdam using mailed home collected urine samples. International Journal of Std & Aids 2004; 15:797 802. van Dijk KN, Plat AW, van Dijk AAC, Piersma Wichers M, de Vries Bots AMB, Slomp J, de Jong van den Berg LTW, Brouwers JRBJ. Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype. Thrombosis and Haemostasis 2004; 91:95 101. van Driel D, Wesseling J, ter Huurne K, Geven Boere LM, Rosendaal FR, van der Veer E, de Jong van den Berg LTW. Adherence to a guideline for coumarins in pregnancy. Pharmacy World & Science 2004; 26:297 300. van Eijk JT, Diederiks JP, Kempen GI, Honig A, van der Meer K, Brenninkmeijer WJ. Development and feasibility of a nurse administered strategy on depression in community dwelling patients with a chronic physical disease. Patient Education and Counseling 2004; 54:87 94. van Grootheest K, van Puijenbroek EP, de Jong van den Berg LTW. Do pharmacists reports of adverse drug reactions reflect patients concerns? Pharmacy World & Science 2004; 26:155 159. van Grootheest K, Olsson S, Couper M, de Jong van den Berg LTW. Pharmacists role in reporting international perspective. Pharmacoepidemiology and Drug Safety 2004; 13:457 464. van Os TW, van den Brink RH, Tiemens BG, Jenner JA, van der Meer K, Ormel J. Are effects of depression management training for General Practitioners on patient outcomes mediated by improvements in the process of care? Journal of Affective Disorders 2004; 80:173 179. van Roon EN, Jansen TLTA, Houtman NM, Spoelstra P, Brouwers JRBJ. Leflunomide for the treatment of rheumatoid arthritis in clinical practice Incidence and severity of hepatotoxicity. Drug Safety 2004; 27:345 352. van Roon EN, Jansen TLTA, Mourad L, Houtman PM, Bruyn GAW, Griep EN, Wilffert B, Tobi H, Brouwers JRBJ. Leflunomide in active rheumatoid arthritis: a prospective study in daily practice. British Journal of Clinical Pharmacology 2004; 57:790 797. top-10% article top-30% article

272 Graduate School for Health Research SHARE Self evaluation 2003-2008 van Roon EN, Yska JP, Raemaekers J, Jansen TLTA, van Wanrooy M, Brouwers JRBJ. A rapid and simple determination of A77 1726 in human serum by high performance liquid chromatography and its application for optimization of leflunomide therapy. Journal of Pharmaceutical and Biomedical Analysis 2004; 36:17 22. Welte R, van den Dobbelsteen G, Bos JM, de Melker H, van Alphen L, Spanjaard L, Rumke HC, Postma MJ. Economic evaluation of meningococcal serogroup C conjugate vaccination programmes in The Netherlands and its impact on decision making. Vaccine 2004; 23:470 479. 2 0 0 5 Al Hadithy AFY, de Boer NKH, Derijks LJJ, Escher JC, Mulder CJJ, Brouwers JRBJ. Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. Digestive and Liver Disease 2005; 37:282 297. Assink N, Bergman GJ, Knoester B, Winters JC, Dijkstra PU, Postema K. Interobserver reliability of neck mobility measurement by means of the flock of birds electromagnetic tracking system. Journal of Manipulative and Physiological Therapeutics 2005; 28:408 413. Atthobari J, Bos JM, Boersma C, Brouwers JRBJ, de Jong van den Berg LTW, Postma MJ. Adherence of pharmacoeconomic studies to national guidelines in the Netherlands. Pharmacy World & Science 2005; 27:364 370. Bergman GJ, Knoester B, Assink N, Dijkstra PU, Winters JC. Variation in the cervical range of motion over time measured by the flock of birds electromagnetic tracking system. Spine 2005; 30:650 654. Bergman GJD. Manipulative therapy for patients with shoulder symptoms In response. Annals of Internal Medicine 2005; 142:226 227. Biegert C, Wagner I, Ludtke R, Kotter I, Lohmuller C, Gunaydin I, Taxis K, Heide L. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: Results of 2 randomized double blind controlled trials. Journal of Rheumatology 2005; 31:2121 2130. Bos JM, Postma MJ, Annemans L. Discounting health effects in pharmacoeconomic evaluations: Current controversies. Pharmacoeconomics 2005; 23:639 649. Brouwer WBF, Niessen LW, Postma MJ, Rutten FFH. Need for differential discounting of costs and health effects in cost effectiveness analyses. British Medical Journal 2005; 331:446 448. Cornel MC, de Smit DJ, de Jong van den Berg LTW. Folic acid the scientific debate as a base for public health policy. Reproductive Toxicology 2005; 20:411 415. de Jong van den Berg LTW, Hernandez Diaz S, Werler MM, Louik C, Mitchell AA. Trends and predictors of folic acid awareness and periconceptional use in pregnant women. American Journal of Obstetrics and Gynecology 2005; 192:121 128. de Jong JCF, Brouwers JRBJ, de Jong van den Berg LTW. Combined use of NSAIDs and SSRIs increases the risk for gastrointestinal adverse effects Response. British Journal of Clinical Pharmacology 2005; 59:119. Duyvendak M, Naunton M, Kingma BJ, Brouwers JRBJ. Thalidomide associated thrombocytopenia. Annals of Pharmacotherapy 2005; 39:1936 1939. Faber A, de Jong van den Berg LTW, Netjes K, Kalverdijk L, Minderaa R, Tobi H. Recruitment of parents and physicians of stimulant using children via community pharmacies is successful. Journal of Clinical Epidemiology 2005; 58:1072 1073. Faber A, de Jong van den Berg LTW, van den Berg PB, Tobi H. Psychotropic co medication among stimulant treated children in The Netherlands. Journal of Child and Adolescent Psychopharmacology 2005; 15:38 43. Faber A, Bouvy ML, Loskamp L, van de Berg PB, Egberts TCG, de Jong van den Berg LTW. Dramatic change in prescribing of hormone replacement therapy in the Netherlands after publication of the Million Women Study: a follow up study. British Journal of Clinical Pharmacology 2005; 60:641 647. Greving JP, Denig P, van der Veen WJ, Beltman FW, Sturkenboom MC, de Zeeuw D, Haaijer Ruskamp FM. Uptake of angiotensin II receptor blockers in the treatment of hypertension. European Journal of Clinical Pharmacology 2005; 61:461 466. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 273 Hart HE, Redekop WK, Bilo HJ, Berg M, Meyboom de Jong B. Change in perceived health and functioning over time in patients with type I diabetes mellitus. Quality of Life Research 2005; 14:1 10. Hoven JL, Haaijer Ruskamp FM, Vander Stichele RH. Indicators of prescribing quality in drug utilisation research: report of a European meeting (DURQUIM, 13 15 May 2004). European Journal of Clinical Pharmacology 2005; 60:831 834. Jaarsma T, Haaijer Ruskamp FM, Sturm H, van Veldhuisen DJ. Management of heart failure in the Netherlands. European Journal of Heart Failure 2005; 7:371 375. Jansma FF, Schure LM, Meyboom de Jong B. Support requirements for caregivers of patients with palliative cancer. Patient Education and Counseling 2005; 58:182 186. Jansman FGA, Jansen AJA, Coenen JLL, de Graaf JC, Smit WM, Sleijfer DT, Brouwers JRB. Assessing the clinical significance of drug interactions with fluorouracil in patients with colorectal cancer. American Journal of Health System Pharmacy 2005; 62:1788 1793. Jansman FGA, Idzinga FSF, Smit WM, de Graaf JC, Coenen JLLM, Sleijfer DT, Brouwers JRBJ. Classification and occurrence of clinically significant drug interactions with irinotecan and oxaliplatin in patients with metastatic colorectal cancer. Clinical Therapeutics 2005; 27:327 335. Kasje WN, Denig P, Stewart RE, de Graeff PA, Haaijer Ruskamp FM. Physician, organisational and patient characteristics explaining the use of angiotensin converting enzyme inhibitors in heart failure treatment: a multilevel study. European Journal of Clinical Pharmacology 2005; 61:145 151. Kleefstra N, Ubink Veltmaat LJ, Houweling ST, Groenier KH, Meyboom de Jong B, Bilo HJ. Cross sectional relationship between glycaemic control, hyperglycaemic symptoms and quality of life in type 2 diabetes (ZODIAC 2). Netherlands Journal of Medicine 2005; 63:215 221. Kleefstra N, Houweling ST, van Ballegooie E, Bilo HJ. Self monitoring of blood glucose in patients with type 2 diabetes who are not using insulin: response to Welschen et al. Diabetes Care 2005; 28:2597 2598. Klok RM, Postma MJ, van Hout BA, Brouwers JR. All proton pump inhibitors are equivalent for treatment of GERD. Cleveland Clinic Journal of Medicine 2005; 72:1100. Klok RM, Arents NLA, de Vries R, Thijs JC, Brouwers JRBJ, Kleibeuker JH, Postma MJ. Economic evaluation of a randomized trial comparing Helicobacter pylori test and treat and prompt endoscopy strategies for managing dyspepsia in a primary care setting. Clinical Therapeutics 2005; 27:1647 1657. Meijer WM, de Walle HEK, Kerstjens Frederikse WS, de Jong van den Berg LTW. Folic acid sensitive birth defects in association with intrauterine exposure to folic acid antagonists. Reproductive Toxicology 2005; 20:203 207. Mol PG, Gans RO, Panday PV, Degener JE, Laseur M, Haaijer Ruskamp FM. Reliability of assessment of adherence to an antimicrobial treatment guideline. Journal of Hospital Infection 2005; 60:321 328. Mol PGM, Wieringa JE, NannanPanday PV, Gans ROB, Degener JE, Laseur M, Haaijer Ruskamp FM. Improving compliance with hospital antibiotic guidelines: a time series intervention analysis. Journal of Antimicrobial Chemotherapy 2005; 55:550 557. Postma MJ, Jansema P, Scheijbeler HWKF, van Genugten MLL. Scenarios on costs and savings of influenza treatment and prevention for Dutch healthy working adults. Vaccine 2005; 23:5365 5371. Postma MJ, van Hulst M, de Wolf JTM, Botteman M, Staginnus U. Cost effectiveness of pathogen inactivation for platelet transfusions in the Netherlands. Transfusion Medicine 2005; 15:379 387. Raz R, Edelstein H, Grigoryan L, Haaijer Ruskamp FM. Self medication with antibiotics by a population in northern Israel. Israel Medical Association Journal 2005; 7:722 725. Reinders MK, van Roon EN, Brouwers JRBJ, Jansen TLTA. A costly therapeutic dilemma in tophaceous gout: is etanercept or rasburicase preferable? Annals of the Rheumatic Diseases 2005; 64:516. Rijcken CAW, Knegtering H, Bruggeman R, Tobi H, de Jong van den Berg LTW. Sex differences in concomitant medication with benzodiazepines or antidepressants in first break schizophrenic patients treated with antipsychotic medication. Psychiatry Research 2005; 134:143 150. Smink BE, Ruiter B, Lusthof KJ, de Gier JJ, Uges DRA, Egberts ACG. Drug use and the severity of a traffic accident. Accident Analysis and Prevention 2005; 37:427 433. top-10% article top-30% article

274 Graduate School for Health Research SHARE Self evaluation 2003-2008 Stokman MA, Sonis ST, Dijkstra PU, Burgerhof JG, Spijkervet FK. Assessment of oral mucositis in clinical trials: Impact of training on evaluators in a multi centre trial. European Journal of Cancer 2005; 41:1735 1738. Sturm HB, van Gilst WH, Swedberg K, Hobbs FR, Haaijer Ruskamp FM. Heart failure guidelines and prescribing in primary care across Europe. BMC Health Services Research 2005; 5:57?. Stuurman Bieze AG, Kokenberg MEAP, Tobi H, de Boer WO, van Doormaal JE, de Jong van den Berg LTW, Tromp TFJ. Complex pharmaceutical care intervention in pulmonary care Part B. Patient opinion and process survey. Pharmacy World & Science 2005; 27:385 392. Stuurman Bieze AGG, de Boer WO, Kokenberg MEAP, Hugtenburg JG, de Jong van den Berg LTW, Tromp THFJ. Complex pharmaceutical care intervention in pulmonary care Part A. The process and pharmacists professional satisfaction. Pharmacy World & Science 2005; 27:376 384. Taxis K. Who is responsible for the safety of infusion devices? It s high time for action! Quality & Safety in Health Care 2005; 14:76. Tobi H, Scheers T, Netjes KA, Mulder EJ, de Bildt A, Minderaa RB. Drug utilisation by children and adolescents with mental retardation: a population study. European Journal of Clinical Pharmacology 2005; 61:297 302. Tobi H, van den Berg PB, de Jong van den Berg LTW. Small proportions: what to report for confidence intervals? Pharmacoepidemiology and Drug Safety 2005; 14:239 247. Ubink Veltmaat LJ, Bilo HJ, Groenier KH, Rischen RO, Meyboom de Jong B. Shared care with task delegation to nurses for type 2 diabetes: prospective observational study. Netherlands Journal of Medicine 2005; 63:103 110. van Hulst M, Bilgin YM, van de Watering LMG, de Vries R, van Oers MHJ, Postma MJ. Cost effectiveness of leucocyte depleted erythrocyte transfusion in cardiac valve surgery. Transfusion Medicine 2005; 15:209 217. van Os TW, van den Brink RH, Tiemens BG, Jenner JA, van der Meer K, Ormel J. Communicative skills of general practitioners augment the effectiveness of guideline based depression treatment. Journal of Affective Disorders 2005; 84:43 51. van Roon EN, Hoekstra M, Tobi H, Jansen TLTA, Bernelot Moens HJ, Brouwers JRBJ, van de Laar MAFJ. Leflunomide in the treatment of rheumatoid arthritis. An analysis of predictors for treatment continuation. British Journal of Clinical Pharmacology 2005; 60:319 325. van Roon EN, Jansen TLTA, van de Laar MAFJ, Janssen M, Yska JP, Keuper R, Houtman PM, Brouwers JRBJ. Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 2005; 64:569 574. van Roon EN, de Laar MAFJ, Janssen M, Kruijsen MWM, Jansen TLTA, Brouwers JRBJ. Parenteral gold preparations. Efficacy and safety of therapy after switching from aurothioglucose to aurothiomalate. Journal of Rheumatology 2005; 32:1026 1030. van Roon EN, Flikweert S, le Comte M, Langendijk PNJ, Kwee Zuiderwijk WJM, Smits P, Brouwers JRBJ. Clinical relevance of drug drug interactions A structured assessment procedure. Drug Safety 2005; 28:1131 1139. van Wayenburg CA, van de Laar FA, de Waal MW, Okkes IM, van den Akker M, van der Veen WJ, Schellevis FG, van Staveren WA, van Binsbergen JJ, van Weel C. Nutritional deficiency in Dutch primary care: data from general practice research and registration networks. European Journal of Clinical Nutrition 2005; 59 Suppl 1:S187 S194. Veurink M, Koster M, de Jong van den Berg LTW. The history of DES, lessons to be learned. Pharmacy World & Science 2005; 27:139 143. Wachters Kaufmann C, Schuling J, The H, Meyboom de Jong B. Actual and desired information provision after a stroke. Patient Education and Counseling 2005; 56:211 217. Welte R, Postma M, Leidl R, Kretzschmar M. Costs and effects of chlamydial screening: Dynamic versus static modeling. Sexually Transmitted Diseases 2005; 32:474 483. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 275 Welte R, Trotter CL, Edmunds WJ, Postma MJ, Beutels P. The role of economic evaluation in vaccine decision making Focus on meningococcal group C conjugate vaccine. Pharmacoeconomics 2005; 23:855 874. Wilffert B, Zaal R, Brouwers JRBJ. Pharmacogenetics as a tool in the therapy of schizophrenia (vol 27, pg 20, 2005). Pharmacy World & Science 2005; 27:267. Wilting I, Movig KL, Moolenaar M, Hekster YA, Brouwers JR, Heerdink ER, Nolen WA, Egberts AC. Drug drug interactions as a determinant of elevated lithium serum levels in daily clinical practice. Bipolar Disorders 2005; 7:274 280. 2 0 0 6 Atthobari J, Asselbergs FW, Boersma C, de Vries R, Hillege HL, van Gilst WH, Gansevoort RT, de Jong PE, de Jong van den Berg LTW, Postma MJ. Cost effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of REnal and vascular ENdstage disease (PREVEND) study and the prevention of REnal and vascular ENdstage disease intervention trial (PREVEND IT). Clinical Therapeutics 2006; 28:432 444. Atthobari J, Brantsma AH, Gansevoort RT, Visser ST, Asselbergs FW, van Gilst WH, de Jong PE, de Jong van den Berg LTW. The effect of statins on urinary albumin excretion and glomerular filtration rate: results from both a randomized clinical trial and an observational cohort study. Nephrology Dialysis Transplantation 2006; 21:3106 3114. Bakker MK, Jentink J, Vroom F, van den Berg PB, de Walle HEK, de Jong van den Berg LTW. Drug prescription patterns before, during and after pregnancy for chronic, occasional and pregnancy related drugs in the Netherlands. Bjog An International Journal of Obstetrics and Gynaecology 2006; 113:559 568. Berendsen AJ, Benneker WH, Schuling J, Rijkers Koorn N, Slaets JP, Meyboom de Jong B. Collaboration with general practitioners: preferences of medical specialists a qualitative study. BMC Health Services Research 2006; 6:art. no 155. Besselink MGH, van Santvoort HC, Bollen TL, van Leeuwen MS, Lameris JS, van der Jagt EJ, Strijk SP, Buskens E, Freeny PC, Gooszen HG. Describing computed tomography findings in acute necrotizing pancreatitis with the Atlanta classification an interobserver agreement study. Pancreas 2006; 33:331 335. Besselink MGH, van Santvoort HC, Buskens E, Gooszen HG. Evidence based treatment of acute pancreatitis: Antibiotic prophylaxis in necrotizing pancreatitis. Annals of Surgery 2006; 244:637 638. Beulens JWJ, van Beers RM, Stolk RP, Schaafsma G, Hendriks HFJ. The effect of moderate alcohol consumption on fat distribution and adipocytokines. Obesity 2006; 14:60 66. Blaauw J, van Pampus MG, van Doormaal JJ, Fokkema MR, Fidler V, Smit AJ, Aarnoudse JG. Increased intima media thickness after early onset preeclampsia. Obstetrics and Gynecology 2006; 107:1345 1351. Boersma C, Atthobari J, Gansevoort RT, de Jong van den Berg LTW, de Jong PE, de Zeeuw D, Annemans LJP, Postma MJ. Pharmacoeconomics of angiotensin II antagonists in type 2 diabetic patients with nephropathy Implications for decision making. Pharmacoeconomics 2006; 24:523 535. Bos JM, Postma MJ, Annemans L. The authors reply. (Discounting health effects in pharmacoeconomic evaluations: current controversies. Birks, S. Pharmacoeconomics 2006;24(12)1273 4 ). Pharmacoeconomics 2006; 24:1275 1276. Bos JM, Rumke HC, Welte R, Spanjaard L, van Alphen L, Postma MJ. Combination vaccine against invasive meningococcal B and pneumococcal infections Potential epidemiological and economic impact in The Netherlands. Pharmacoeconomics 2006; 24:141 153. Buitenhuis J, Jaspers JPC, Fidler V. Can kinesiophobia predict the duration of neck symptoms in acute whiplash? Clinical Journal of Pain 2006; 22:272 277. Buskens E. No nonagenarians please! (letter). Archives of Surgery 2006; 141:104. Cohen D, Stolk RP, Grobbee DE, Gispen De Wied CC. Hyperglycemia and diabetes in patients with schizophrenia or schizoaffective disorders. Diabetes Care 2006; 29:786 791. Costacou T, Huskey ND, Edmundowicz D, Stolk R, Orchard TJ. Lower extremity arterial calcification as a correlate of coronary artery calcification. Metabolism Clinical and Experimental 2006; 55:1689 1696. top-10% article top-30% article

276 Graduate School for Health Research SHARE Self evaluation 2003-2008 Crijns APG, Gerbens F, Plantinga AED, Meersma GJ, de Jong S, Hofstra RMW, de Vries EGE, van der Zee AGJ, de Bock GH, te Meerman GJ. A biological question and a balanced (orthogonal) design: the ingredients to efficiently analyze two color microarrays with Confirmatory Factor Analysis. Bmc Genomics 2006; 7:Art. No. 232. de Bock GH, van der Hage JA, Putter H, Bonnema J, Bartelink H, van de Velde CJ. Isolated loco regional recurrence of breast cancer is more common in young patients and following breast conserving therapy: Long term results of European Organisation for Research and Treatment of Cancer studies. European Journal of Cancer 2006; 42:351 356. de Bock GH, Mourits MJ, Schutte M, Krol Warmerdam EM, Seynaeve C, Blom J, Brekelmans CT, Meijers Heijboer H, van Asperen CJ, Cornelisse CJ, Devilee P, Tollenaar RA, Klijn JG. Association between the CHEK21100delC germ line mutation and estrogen receptor status. International Journal of Gynecological Cancer 2006; 16 Suppl 2:552 555. de Buck PDM, de Bock GH, van Dijk F, van den Hout WB, Vandenbroucke JP, Vlieland TPMV. Sick leave as a predictor of job loss in patients with chronic arthritis. International Archives of Occupational and Environmental Health 2006; 80:160 170. de Graeff P, Hall J, Crijns APG, de Bock GH, Paul J, Oien KA, ten Hoor KA, de Jong S, Hollema H, Bartlett JMS, Brown R, van der Zee AGJ. Factors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies. British Journal of Cancer 2006; 95:627 633. de Jong van den Berg LTW. Prevention of NTDs: New strategies are needed Reply. American Journal of Obstetrics and Gynecology 2006; 194:1741. de Jong van den Berg LTW, Faber A, van den Berg PB. HRT use in 2001 and 2004 in The Netherlands A world of difference. Maturitas 2006; 54:193 197. de Nijs RNJ, Jacobs JWG, Lems WF, Laan RFJ, Algra A, Huisman A, Buskens E, de Laet CED, Oostveen ACM, Geusens PPMM, Bruyn GAW, Dijkmans BAC, Bijlsma JWJ. Alendronate or alfacalcidol in glucocorticoid induced osteoporosis. New England Journal of Medicine 2006; 355:675 684. de Roos MA, Groote AD, Pijnappel RM, Post WJ, de Vries J, Baas PC. Small size ductal carcinoma in situ of the breast: Predictors of positive margins after local excision. International Surgery 2006; 91:100 106. de Vries R, van Bergen JEAM, de Jong van den Berg LTW, Postma MJ. Systematic screening for Chlamydia trachomatis: Estimating cost effectiveness using dynamic modeling and Dutch data. Value in Health 2006; 9:1 11. de Vries TW, Tobi H, Schirm E, van den Berg P, Duiverman EJ, de Jong van den Berg LTW. The gap between evidence based medicine and daily practice in the management of paediatric asthma. A pharmacy based population study from The Netherlands. European Journal of Clinical Pharmacology 2006; 62:51 55. de Vries TW, Langen Wouterse JJ, van Puijenbroek E, Duiverman EJ, de Jong van den Berg LTW. Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands. European Journal of Clinical Pharmacology 2006; 62:343 346. Dobre D, van Jaarsveld CHM, Ranchor AV, Arnold R, de Jongste MJL, Haaijer Ruskamp FM. Evidence based treatment and quality of life in heart failure. Journal of Evaluation in Clinical Practice 2006; 12:334 340. Doting EH, de Vries M, Plukker JTM, Jager PL, Post WJ, Suurmeijer AJH, Hoekstra HJ. Does sentinel lymph node biopsy in cutaneous head and neck melanoma alter disease outcome? Journal of Surgical Oncology 2006; 93:564 570. Draaisma WA, Buskens E, Bais JE, Simmermacher RKJ, Rijnhart de Jong HG, Broeders IAMJ, Gooszen HG. Randomized clinical trial and follow up study of cost effectiveness of laparoscopic versus conventional Nissen fundoplication. British Journal of Surgery 2006; 93:690 697. Draaisma WA, Ruurda JP, Scheffer RCH, Simmermacher RKJ, Gooszen HG, Rijnhart de Jong HG, Buskens E, Broeders IAMJ. Randomized clinical trial of standard laparoscopic versus robot assisted laparoscopic Nissen fundoplication for gastro oesophageal reflux disease. British Journal of Surgery 2006; 93:1351 1359. Faber A, Kalverdijk LJ, de Jong van den Berg LTW, Hugtenburg JG, Minderaa RB, Tobi H. Parents report on stimulant treated children in the Netherlands: Initiation of treatment and follow up care. Journal of Child and Adolescent Psychopharmacology 2006; 16:432 440. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 277 Fokkema E, Timens W, de Vries EGE, de Jong S, Fidler V, Meijer C, Groen HJM. Expression and prognostic implications of apoptosis related proteins in locally unresectable non small cell lung cancers. Lung Cancer 2006; 52:241 247. Forouhi NG, Balkau B, Borch Johnsen K, Dekker J, Glumer C, Qiao Q, Spijkerman A, Stolk R, Tabac A, Wareham NJ. The threshold for diagnosing impaired fasting glucose: a position statement by the European Diabetes Epidemiology Group. Diabetologia 2006; 49:822 827. Foster JM, van Sonderen E, Lee AJ, Sanderman R, Dijkstra A, Postma DS, van der Molen T. A self rating scale for patient perceived side effects of inhaled corticosteroids. Respiratory Research 2006; 7:Art. no. 131. Greving JP, Denig P, van der Veen WJ, Beltman FW, Sturkenboom MCJM, Haaijer Ruskamp FM. Determinants for the adoption of angiotensin II receptor blockers by general practitioners. Social Science & Medicine 2006; 63:2890 2898. Greving JP, Denig P, de Zeeuw D, Haaijer Ruskamp FM. Physicians attitudes towards treatment guidelines: differences between teaching and nonteaching hospitals. European Journal of Clinical Pharmacology 2006; 62:129 133. Grigoryan L, Haaijer Ruskamp FM, Burgerhof JGM, Mechtler R, Deschepper R, Tambic Andrasevic A, Andrajati R, Monnet DL, Cunney R, Di Matteo A, Edelstein H, Valinteliene R, Alkerwi A, Scicluna EA, Grzesiowski P, Bara AC, Tesar T, Cizman M, Campos J, Lundborg CS, Birkin J. Self medication with antimicrobial drugs in Europe. Emerging Infectious Diseases 2006; 12:452 459. Groenier KH, Winters JC, van Schuur WH, de Winter AF, Meyboom de Jong B. A simple classification system was recommended for patients with restricted shoulder or neck range of motion. Journal of Clinical Epidemiology 2006; 59:599 607. Hak E, Meijboom MJ, Buskens E. Modelling the health economic impact of the next influenza pandemic in The Netherlands. Vaccine 2006; 24:6756 6760. Hak E, Buskens E, Nichol KL, Verheij TJM. Do recommended high risk adults benefit from a first influenza vaccination? Vaccine 2006; 24:2799 2802. Heijenbrok Kal MH, Buskens E, Nederkoorn PJ, van der Graaf Y, Hunink MGM. Optimal peak systolic velocity threshold at duplex US for determining the need for carotid practice endarterectomy: A decision analytic approach. Radiology 2006; 238:480 488. Houweling ST, Kleefstra N, Lutgers HL, Groenier KH, Meyboom de Jong B, Bilo HJG. Pitfalls in blood pressure measurement in daily practice. Family Practice 2006; 23:20 27. Jacobi CE, Nagelkerke NJD, van Houwelingen JC, de Bock GH. Breast cancer screening, outside the population screening program, of women from breast cancer families without proven BRCA1/BRCA2 mutations: a simulation study. Cancer Epidemiology Biomarkers & Prevention 2006; 15:429 436. Jansen GJ, Dassen TWN, Burgerhof JGM, Middel B. Psychiatric nurses attitudes towards inpatient aggression: Preliminary report of the development of Attitude Towards Aggression Scale (ATAS). Aggressive Behavior 2006; 32:44 53. Janssen MP, van der Poel CL, Buskens E, Bonneux L, Bonsel GJ, van Hout BA. Costs and benefits of bacterial culturing and pathogen reduction in the Netherlands. Transfusion 2006; 46:956 965. Kasje WN, Denig P, Stewart RE, de Graeff PA, Haaijer Ruskamp FM. An educational programme for peer review groups to improve treatment of chronic heart failure and diabetes mellitus type 2 in general practice. Journal of Evaluation in Clinical Practice 2006; 12:613 621. Kho YH, Jansman FGA, Prins NH, Neef C, Brouwers JRBJ. Population pharmacokinetics of oxaliplatin (85 mg/m(2)) in combination with 5 fluorouracil in patients with advanced colorectal cancer. Therapeutic Drug Monitoring 2006; 28:206 211. Kleefstra N, Houweling ST, Jansman FGA, Groenier KH, Gans ROB, Meyboom de Jong B, Bakker SJL, Bilo HJG. Chromium treatment has no effect in patients with poorly controlled, insulin treated type 2 diabetes in an obese western population A randomized, double blind, placebo controlled trial. Diabetes Care 2006; 29:521 525. Klein WM, van der Graaf Y, Seegers J, Spithoven JH, Buskens E, van Baal JG, Buth J, Moll FL, Overtoom TTC, van Sambeek MRHM, Mali WPTM. Dutch iliac stent trial: Long term results in patients randomized for primary or selective stent placement. Radiology 2006; 238:734 744. top-10% article top-30% article

278 Graduate School for Health Research SHARE Self evaluation 2003-2008 Klok RM, Boersma C, Oosterhuis I, Visser ST, de Jong van den Berg LTW, Postma MJ. Switch patterns before and after patent expiry of omeprazole: a case study in The Netherlands. Alimentary Pharmacology & Therapeutics 2006; 23:1595 1600. Koek MBG, Buskens E, Bruijnzeel Koomen CAFM, Sigurdsson V. Home ultraviolet B phototherapy for psoriasis: discrepancy between literature, guidelines, general opinions and actual use. Results of a literature review, a web search, and a questionnaire among dermatologists. British Journal of Dermatology 2006; 154:701 711. Kramer H, Sanders J, Post WJ, Groen HJ, Suurmeijer AJ. Analysis of cytological specimens from mediastinal lesions obtained by endoscopic ultrasound guided fine needle aspiration. Cancer 2006; 108:206 211. Kramer H, Post WJ, Pruim J, Groen HJM. The prognostic value of positron emission tomography in non small cell lung cancer: Analysis of 266 cases. Lung Cancer 2006; 52:213 217. Krapels IPC, Zielhuis GA, Vroom F, de Jong van den Berg LTW, Kuijpers Jagtman AM, van der Molen ABM, Steegers Theunissen RPM. Periconceptional health and lifestyle factors of both parents affect the risk of live born children with orofacial clefts. Birth Defects Research Part A Clinical and Molecular Teratology 2006; 76:613 620. Laan W, Selten JP, Kahn RS, Huisman AM, Heijnen CJ, Grobbee DE, Burger H. Acetylsalicylic acid as an adjuvant therapy for schizophrenia. Trials 2006; 7:Art. No. 31. Looijmans Van den Akker I, Verheij TJM, Buskens E, Nichol KL, Rutten GEHM, Hak E. Clinical effectiveness of first and repeat influenza vaccination in adult and elderly diabetic patients. Diabetes Care 2006; 29:1771 1776. Lub R, Denig P, van den Berg PB, Hoogenberg K, de Jong van den Berg LTW. The impact of new insights and revised practice guidelines on prescribing drugs in the treatment of type 2 diabetes mellitus. British Journal of Clinical Pharmacology 2006; 62:660 665. Luinge MR, Post WJ, Wit HP, Goorhuis Brouwer SM. The ordering of milestones in language development for children from 1 to 6 years of age. Journal of Speech Language and Hearing Research 2006; 49:923 940. Meijer WM, Werler MM, Louik C, Hernandez Diaz S, de Jong van den Berg LTW, Mitchell AA. Can folic acid protect against congenital heart defects in Down syndrome? Birth Defects Research Part A Clinical and Molecular Teratology 2006; 76:714 717. Meijer WM, Cornel MC, Dolk H, de Walle HEK, Armstrong NC, de Jong van den Berg LTW. The potential of the European network of congenital anomaly registers (EUROCAT) for drug safety surveillance: a descriptive study. Pharmacoepidemiology and Drug Safety 2006; 15:675 682. Meijer WM, de Jong van den Berg LTW, van den Berg MD, Verheij JBGM, de Walle HEK. Clomiphene and hypospadias on a detailed level: Signal or chance? Birth Defects Research Part A Clinical and Molecular Teratology 2006; 76:249 252. Meiland R, Geerlings SE, Stolk RP, Netten PM, Schneeberger PM, Hoepelman AIM. Asymptomatic bacteriuria in women with diabetes mellitus Effect on renal function after 6 years of follow up. Archives of Internal Medicine 2006; 166:2222 2227. Mol PGM, Denig P, Gans ROB, NannanPanday PV, Degener JE, Laseur M, Haaijer Ruskamp FM. Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines. European Journal of Clinical Pharmacology 2006; 62:297 305. Morré SA, Spaargaren J, Veldhuijzen IK, Postma MJ, van Bergen JEAM. Evaluation of the leukocyte esterase test (LET) as pre screening test to reduce costs for national population based Chlamydia trachomatis screening programs. Journal of Adolescent Health 2006; 38:332 333. Mourits MJ, de Bock GH. Exogenous steroids for menopausal symptoms and breast/endometrial cancer risk. International Journal of Gynecological Cancer 2006; 16 Suppl 2:494 496. Mourits MJE, van der Velde NM, Arts HJG, de Bock GH. High percentage of abnormal findings on TVU needs further discussion (letter). British Journal of Cancer 2006; 95:1125. Muis MJ, Bots ML, Bilo HJG, Hoogma RPLM, Hoekstra JBL, Grobbee DE, Stolk RP. Determinants of daily insulin use in type 1 diabetes. Journal of Diabetes and Its Complications 2006; 20:356 360. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 279 Muscat M, Monnet DL, Klemmensen T, Grigoryan L, Jensen MH, Andersen M, Haaijer Ruskamp FM. Patterns of antibiotic use in the community in Denmark. Scandinavian Journal of Infectious Diseases 2006; 38:597 603. Nathoe HM, Koerselman J, Buskens E, van Dijk D, Stella PR, Plokker THW, Doevendans PAFM, Grobee DE, de Jaegere PPT. Determinants and prognostic significance of collaterals in patients undergoing coronary revascularization. American Journal of Cardiology 2006; 98:31 35. Naunton M, Duyvendak M, Peterson GM, Brouwers JRBJ. Comments on Glintborg et al. s drug drug interactions study (EJCP 2005; 61 : 675 681). European Journal of Clinical Pharmacology 2006; 62:159 160. Naunton M, Duyvendak M, Peterson GM, Brouwers JRBJ. Practice patterns in osteoporosis prevention in patients on glucocorticoids. Osteoporosis International 2006; 17:634 635. Naunton M, Al Hadithy AFY, Brouwers JRBJ, Archer DF. Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women. Menopause the Journal of the North American Menopause Society 2006; 13:517 527. Niessen RC, Sijmons RH, Ou J, Olthof SGM, Osinga J, Ligtenberg MJ, Hogervorst FBL, Weiss MM, Tops CMJ, Hes FJ, de Bock GH, Buys CHCM, Kleibeuker JH, Hofstra RMW. MUTYH and the mismatch repair system: partners in crime? Human Genetics 2006; 119:206 211. Patel A, Huang KC, Janus ED, Gill T, Neal B, Suriyawongpaisal P, Wong E, Woodward M, Stolk RP. Is a single definition of the metabolic syndrome appropriate? A comparative study of the USA and Asia. Atherosclerosis 2006; 184:225 232. Peppelenbosch N, Geelkerken RH, Soong C, Cao P, Steinmetz OK, Teijink JAW, Lepantalo M, de Letter J, Vermassen FEG, DeRose G, Buskens E, Buth J. Endograft treatment of ruptured abdominal aortic aneurysms using the talent aortouniiliac system: An international multicenter study. Journal of Vascular Surgery 2006; 43:1111 1121. Putter H, van der Hage J, de Bock GH, Elgalta R, van de Velde CJH. Estimation and prediction in a multi state model for breast cancer. Biometrical Journal 2006; 48:366 380. Schirm E, de Vries TW, Tobi H, van den Berg PB, de Jong van den Berg LTW. Prescribed doses of inhaled steroids in Dutch children: too little or too much, for too short a time. British Journal of Clinical Pharmacology 2006; 62:383 390. Schoonhoven L, Grobbee DE, Donders ART, Algra A, Grypdonck MH, Bousema MT, Schrijvers AJP, Buskens E. Prediction of pressure ulcer development in hospitalized patients: a tool for risk assessment. Quality & Safety in Health Care 2006; 15:65 70. Schure LM, van den Heuvel ETP, Stewart RE, Sanderman R, de Witte LP, Meyboom de Jong B. Beyond stroke: Description and evaluation of an effective intervention to support family caregivers of stroke patients. Patient Education and Counseling 2006; 62:46 55. Smink BE, Mathijssen MPM, Lusthof KJ, de Gier JJ, Egberts ACG, Uges DRA. Comparison of urine and oral fluid as matrices for screening of thirty three benzodiazepines and benzodiazepine like substances using immunoassay and LC MS( MS). Journal of Analytical Toxicology 2006; 30:478 485. Smit A, Kluiter H, Conradi HJ, van der Meer K, Tiemens BG, Jenner JA, van Os TWDP, Ormel J. Short term effects of enhanced treatment for depression in primary care: results from a randomized controlled trial. Psychological Medicine 2006; 36:15 26. Span MM, TenVergert EM, van der Hilst CS, Stolk RP. Noninferiority testing in cost minimization studies: Practical issues concerning power analysis. International Journal of Technology Assessment in Health Care 2006; 22:261 266. Spijker J, de Graaf R, Ormel J, Nolen WA, Grobbee DE, Burger H. The persistence of depression score. Acta Psychiatrica Scandinavica 2006; 114:411 416. Sturm HB, Haaijer Ruskamp FM, Veeger NJ, Balje Volkers CP, Swedberg K, van Gilst WH. The relevance of comorbidities for heart failure treatment in primary care: A European survey. European Journal of Heart Failure 2006; 8:31 37. van der Linden YM, Steentand E, van Houwelingen HC, Post WJ, Oei B, Marijnen CAM, Leer JWH. Patients with a favourable prognosis are equally palliated with single and multiple fraction radiotherapy: Results on survival in the Dutch Bone Metastasis Study. Radiotherapy and Oncology 2006; 78:245 253. top-10% article top-30% article

280 Graduate School for Health Research SHARE Self evaluation 2003-2008 van der Schaaf IC, Wermer MJH, Velthuis BK, Buskens E, Bossuyt PMM, Rinkel GJE. Psychosocial impact of finding small aneurysms that are left untreated in patients previously operated on for ruptured aneurysms. Journal of Neurology Neurosurgery and Psychiatry 2006; 77:748 752. van der Zaag Loonen H, Dikkers R, de Bock GH, Oudkerk M. The clinical value of a negative multi detector computed tomographic angiography in patients suspected of coronary artery disease: a meta analysis. European Radiology 2006; 16:2748 2756. van Eck JWM, van Hemel NM, Grobbee DE, Buskens E, Moons KGM. FOLLOWPACE study: a prospective study on the cost effectiveness of routine follow up visits in patients with a pacemaker. Europace 2006; 8:60 64. van Hecke MV, Dekker JM, Nijpels G, Stolk RP, Henry RMA, Heine RJ, Bouter LM, Stehouwer CDA, Polak BCP. Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima media thickness? The Hoorn Study. Clinical Science 2006; 110:597 604. van Os TWDP, van den Brink RHS, van der Meer K, Ormel J. The care provided by general practitioners for persistent depression. European Psychiatry 2006; 21:87 92. van Stel HF, Buskens E. Comparison of the SF 6D and the EQ 5D in patients with coronary heart disease. Health and Quality of Life Outcomes 2006; 4:Art. No. 20. Ververs T, Kaasenbrood H, Visser G, Schobben F, de Jong van den Berg LTW, Egberts T. Prevalence and patterns of antidepressant drug use during pregnancy. European Journal of Clinical Pharmacology 2006; 62:863 870. Vonkeman HE, van de Laar MAFJ, Brouwers JRBJ, Vermes I. Allele variants of the cytochrome P4502C9 genotype in white subjects from the Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs. Clinical Therapeutics 2006; 28:1670 1676. Vonkeman HE, Brouwers JRBJ, van de Laar MAFJ. Practice pointer Understanding the NSAID related risk of vascular events. British Medical Journal 2006; 332:895 898. Vrancken AFJE, Kalmijn S, Buskens E, Franssen H, Vermeulen M, Wokke JHJ, Notermans NC. Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. Journal of Neurology Neurosurgery and Psychiatry 2006; 77:397 401. Vroom F, de Walle HEK, van de Laar MAJF, Brouwers JRBJ, de Jong van den Berg LTW. Disease modifying antirheumatic drugs in pregnancy Current status and implications for the future. Drug Safety 2006; 29:845 863. Woolderink JM, de Bock GH, de Hullu JA, Davy MJ, van der Zee AGJ, Mourits MJE. Patterns and frequency of recurrences of squamous cell carcinoma of the vulva. Gynecologic Oncology 2006; 103:293 299. Zito JM, Tobi H, de Jong van den Berg LTW, Fegert JM, Safer DJ, Janhsen K, Hansen DG, Gardner JF, Glaeske G. Antidepressant prevalence for youths: a multi national comparison. Pharmacoepidemiology and Drug Safety 2006; 15:793 798. 2 0 07 Atthobari J, Gansevoort RT, de Jong van den Berg LTW, de Jong PE. Statins and renal function. Is the compound and dose making a difference? Reply. Nephrology Dialysis Transplantation 2007; 22:964. Atthobari J, Gansevoort RT, Visser ST, de Jong PE, de Jong van den Berg LTW. The impact of hormonal contraceptives on blood pressure, urinary albumin excretion and glomerular filtration rate. British Journal of Clinical Pharmacology 2007; 63:224 231. Atthobari J, Gansevoort RT, Visser ST, de Jong PE, de Jong van den Berg L.T. The effect of screening for cardio renal risk factors on drug use in the general population. British Journal of Clinical Pharmacology 2007; 64:810 818. Bakker MK, de Walle HE, Dequito A, van den Berg PB, de Jong van den Berg LT. Selection of controls in case control studies on maternal medication use and risk of birth defects. Birth defects research Part A, Clinical and Molecular Teratology 2007; 79:652 656. Beinema MJ, de Jong PH, Salden HJM, van Wijnen M, van der Meer J, Brouwers JRBJ. The influence of NSAIDs on coumarin sensitivity in patients with CYP2C9 polymorphism after total hip replacement surgery. Molecular Diagnosis & Therapy 2007; 11:123 128. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 281 Berendsen AJ, Benneker WHGM, Meyboom de Jong B, Klazinga NS, Schuling J. Motives and preferences of general practitioners for new collaboration models with medical specialists: a qualitative study. BMC Health Services Research 2007; 7. Besselink MG, Verwer TJ, Schoenmaeckers EJ, Buskens E, Ridwan BU, Visser MR, Nieuwenhuijs VB, Gooszen HG. Timing of surgical intervention in necrotizing pancreatitis. Archives of Surgery 2007; 142:1194 1201. Beulens JW, de Bruijne LM, Stolk RP, Peeters PH, Bots ML, Grobbee DE, van der Schouw YT. High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle aged women: a population based follow up study. Journal of the American College of Cardiology 2007; 50:14 21. Blaauwbroek R, Stant AD, Groenier KH, Kamps WA, Meyboom B, Postma A. Health related quality of life and adverse late effects in adult (very) long term childhood cancer survivors. European Journal of Cancer 2007; 43:122 130. Boersma C, Carides GW, Atthobari J, Voors AA, Postma MJ. An economic assessment of losartan based versus atenolol based therapy in patients with hypertension and left ventricular hypertrophy: Results from the Losartan Intervention For Endpoint reduction (LIFE) study adapted to The Netherlands. Clinical Therapeutics 2007; 29:963 971. Bos JM, Rietveld E, Moll HA, Steyerberg EW, Luytjes W, Wilschut JC, de Groot R, Postma MJ. The use of health economics to guide drug development decisions: Determining optimal values for an RSV vaccine in a model based scenario analytic approach. Vaccine 2007; 25:6922 6929. Bozkurt O, de Boer A, Grobbee DE, Heerdink ER, Burger H, Klungel OH. Pharmacogenetics of glucose lowering drug treatment A Systematic review. Molecular Diagnosis & Therapy 2007; 11:291 302. Brouwer BG, Visseren FL, Stolk RP, van der GY. Abdominal fat and risk of coronary heart disease in patients with peripheral arterial disease. Obesity 2007; 15:1623 1630. Buijs C, Rodenhuis S, Seynaeve CM, van Hoesel QG, van der Wall E, Smit WJ, Nooij MA, Voest E, Hupperets P, TenVergert EM, van Tinteren H, Willemse PH, Mourits MJ, Aaronson NK, Post WJ, de Vries EG. Prospective study of long term impact of adjuvant high dose and conventional dose chemotherapy on health related quality of life. Journal of Clinical Oncology 2007; 25:5403 5409. Buskens E, van Staaij B, van den Akker J, Hoes AW, Schilder AGM. Adenotonsillectomy or watchful waiting in patients with mild to moderate symptoms of throat infections or adenotonsillar hypertrophy A Randomized comparison of costs and effects. Archives of Otolaryngology Head & Neck Surgery 2007; 133:1083 1088. Chedoe I, Molendijk HA, Dittrich STAM, Jansman FGA, Harting JW, Brouwers JRBJ, Taxis K. Incidence and nature of medication errors in neonatal intensive care with strategies to improve safety A review of the current literature. Drug Safety 2007; 30:503 513. Coenen S, Ferech M, Haaijer Ruskamp FM, Butler CC, Stichele RHV, Verheij TJM, Monnet DL, Goossens PLH. European Surveillance of antimicrobial consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Quality & Safety in Health Care 2007; 16:440 445. Conradi HJ, de Jonge P, Kluiter H, Smit A, van der Meer K, Jenner JA, van Os TWDP, Emmelkamp PMG, Ormel J. Enhanced treatment for depression in primary care: long term outcomes of a psycho educational prevention program alone and enriched with psychiatric consultation or cognitive behavioral therapy. Psychological Medicine 2007; 37:849 862. Crijns AP, de Graeff P, Geerts D, ten Hoor KA, Hollema H, van der Sluis T, Hofstra RM, de Bock GH, de Jong S, van der Zee AG, de Vries EG. MEIS and PBX homeobox proteins in ovarian cancer. European Journal of Cancer 2007; 43:2495 2505. Dasselaar JJ, Huisman RM, de Jong PE, Burgerhof JGM, Franssen CFM. Effects of relative blood volume controlled hemodialysis on blood pressure and volume status in hypertensive patients. ASAIO Journal 2007; 53:357 364. de Bock GH, Mourits MJE, Oosterwijk JC. One risk fits all? (letter). Journal of Clinical Oncology 2007; 25:3383 3384. de Graeff P, Hall J, Crijns APG, de Bock GH, Paul J, ten Hoor KA, de Jong S, Hollema H, Bartlett JMS, Brown R, van der Zee AGJ. The classification of p53 immunohistochemical staining results and patient outcome in ovarian cancer Reply. British Journal of Cancer 2007; 96:1623 1624. top-10% article top-30% article

282 Graduate School for Health Research SHARE Self evaluation 2003-2008 de Groot M, de Keijser J, Neeleman J, Kerkhof A, Nolen W, Burger H. Cognitive behaviour therapy to prevent complicated grief among relatives and spouses bereaved by suicide: cluster randomised controlled trial. British Medical Journal 2007; 334:994 996A. de Krom M, van der Schouw YT, Hendriks J, Ophoff RA, van Gils CH, Stolk RP, Grobbee DE, Adan R. Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 2007; 56:276 280. de Roos MA, de Bock GH, de Vries J, van der Vegt B, Wesseling J. p53 overexpression is a predictor of local recurrence after treatment for both in situ and invasive ductal carcinoma of the breast. Journal of Surgical Research 2007; 140:109 114. de Roos MA, van der Vegt B, de Vries J, Wesseling J, de Bock GH. Pathological and biological differences between screen detected and interval ductal carcinoma in situ of the breast. Annals of Surgical Oncology 2007; 14:2097 2104. de Roos MAJ, van der Vegt B, Peterse JL, Patriarca C, de Vries J, de Bock GH, Wesseling J. The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome in pure ductal carcinoma in situ of the breast. Histopathology 2007; 51:227 238. de Vries AC, Besselink MG, Buskens E, Ridwan BU, Schipper M, van Erpecum KJ, Gooszen HG. Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome. Pancreatology 2007; 7:531 538. de Vries TW, Langen Wouterse JJ, de Jong van den Berg LTW, Duiverman EJ. Hypertrichosis as a side effect of inhaled steroids in children. Pediatric Pulmonology 2007; 42:370 373. de Walle HEK, de Jong van den Berg LTW. Growing gap in folic acid intake with respect to level of education in the Netherlands. Community Genetics 2007; 10:93 96. de Weert van Oene GH, Burger H, Grobbee DE, Schrijvers AJP. Identification of patients at high risk of noncompliance in substance dependence treatment. European Addiction Research 2007; 13:74 80. Dobre D, Haaijer Ruskamp FM, Voors AA, van Veldhuisen DJ. Beta adrenoceptor antagonists in elderly patients with heart failure: a critical review of their efficacy and tolerability. Drugs & Aging 2007; 24:1031 1044. Dobre D, van Veldhuisen DJ, DeJongste MJ, van Sonderen E, Klungel OH, Sanderman R, Ranchor AV, Haaijer Ruskamp FM. The contribution of observational studies to the knowledge of drug effectiveness in heart failure. British Journal of Clinical Pharmacology 2007; 64:406 414. Dobre D, van Veldhuisen DJ, DeJongste MJ, Lucas C, Cleuren G, Sanderman R, Ranchor AV, Haaijer Ruskamp FM. Prescription of beta blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival. European Journal of Heart Failure 2007; 9:280 286. Dobre D, van Jaarsveld CHM, DeJongste MJ, Haaijer Ruskamp FM, Ranchor AV. The effect of beta blocker therapy on quality of life in heart failure patients: a systematic review and meta analysis. Pharmacoepidemiology and Drug Safety 2007; 16:152 159. Dobre D, van Veldhuisen DJ, Mordenti G, Vintila M, Haaijer Ruskamp FM, Coats AJS, Poole Wilson PA, Flather MD. Tolerability and dose related effects of nebivolol in elderly patients with heart failure: Data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial. American Heart Journal 2007; 154:109 115. Dobre D, DeJongste MJ, Lucas C, Cleuren G, van Veldhuisen DJ, Ranchor AV, Haaijer Ruskamp F. Effectiveness of beta blocker therapy in daily practice patients with advanced chronic heart failure; is there an effect modification by age? British Journal of Clinical Pharmacology 2007; 63:356 364. Dorrestijn O, Stevens M, Diercks RL, van der Meer K, Winters JC. A new interdisciplinary treatment strategy versus usual medical care for the treatment of subacromial impingement syndrome: a randomized controlled trial. Bmc Musculoskeletal Disorders 2007; 8. Doting MHE, de Vries M, Plukker JT, Jager PL, Post WJ, Suurmeijer AJ, Hoekstra HJ. Response: The value of sentinel lymph node biopsy in the management of head and neck melanoma (letter). Journal of Surgical Oncology 2007; 95:523. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 283 Driel ML, Coenen S, Dirven K, Lobbestael J, Janssens I, Van Royen P, Haaijer Ruskamp FM, De Meyere M, De Maeseneer J. What is the role of quality circles in strategies to optimise antibiotic prescribing? A pragmatic cluster randomised controlled trial in primary care. Quality & Safety in Health Care 2007; 16:197 202. Duyvendak M, Naunton M, Atthobari J, van den Berg PB, Brouwers JRBJ. Corticosteroid induced osteoporosis prevention: longitudinal practice patterns in The Netherlands 2001 2005. Osteoporosis International 2007; 18:1429 1433. Faber A, Keizer RJ, van den Berg PB, de Jong van den Berg LTW, Tobi H. Use of double blind placebo controlled N of 1 trials among stimulant treated youths in The Netherlands: a descriptive study. European Journal of Clinical Pharmacology 2007; 63:57 63. Finkers F, Maring JG, Boersma F, Taxis K. A study of medication reviews to identify drug related problems of polypharmacy patients in the Dutch nursing home setting. Journal of Clinical Pharmacy and Therapeutics 2007; 32:469 476. Foster JM, van der Molen T, de Jong van den Berg LTW. Patient reporting of side effects may provide an important source of information in clinical practice. European Journal of Clinical Pharmacology 2007; 63:979 980. Gibcus JH, Menkema L, Mastik MF, Hermsen MA, de Bock GH, van Velthuysen ML, Takes RP, Kok K, Alvarez Marcos CA, van der Laan BF, van den Brekel MW, Langendijk JA, Kluin PM, van der Wal JE, Schuuring E. Amplicon mapping and expression profiling identify the Fas associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clinical Cancer Research 2007; 13:6257 6266. Gravelle H, Brouwer WBF, Niessen LW, Postma MJ, Rutten FFH. Discounting in economic evaluations: stepping forward towards optimal decision rules. Health Economics 2007; 16:307 317. Greuter MJW, Dijkstra H, Groen JM, Vliegenthart R, de Lange F, Renerna WKJ, de Bock GH, Oudkerk M. 64 slice MDCT generally underestimates coronary calcium scores as compared to EBT: A phantom study. Medical Physics 2007; 34:3510 3519. Greving JP, Denig P, de Zeeuw D, Haaijer Ruskamp FM. Claims in advertisements for anti hypertensive drugs in a Dutch medical journal. Journal of Hypertension 2007; 25:713 722. Grigoryan L, Burgerhof JGM, Haaijer Ruskamp FM, Degener JE, Deschepper R, Monnet DL, Di Matteo A, Scicluna EA, Bara AC, Lundborg CS, Birkin J. Is self medication with antibiotics in Europe driven by prescribed use? Journal of Antimicrobial Chemotherapy 2007; 59:152 156. Grigoryan L, Burgerhof JG, Degener JE, Deschepper R, Lundborg CS, Monnet DL, Scicluna EA, Birkin J, Haaijer Ruskamp FM. Attitudes, beliefs and knowledge concerning antibiotic use and self medication: a comparative European study. Pharmacoepidemiology and Drug Safety 2007; 16:1234 1243. Grossmann I, de Bock GH, Kranenbarg WMMK, de Velde CJHV, Wiggers T. Carcinoembryonic antigen (CEA) measurement during follow up for rectal carcinoma is useful even if normal levels exist before surgery. A retrospective study of CEA values in the TME trial. EJSO 2007; 33:183 187. Grossmann I, de Bock GH, van de Velde CJH, Kievit J, Wiggers T. Results of a national survey among Dutch surgeons treating patients with colorectal carcinoma. Current opinion about follow up, treatment of metastasis, and reasons to revise follow up practice. Colorectal Disease 2007; 9:787 792. Haeck IM, Timmer de Mik L, Lentjes EG, Buskens E, Hijnen DJ, Guikers C, Bruijnzeel Koomen CA, de Bruin Weller MS. Low basal serum cortisol in patients with severe atopic dermatitis: potent topical corticosteroids wrongfully accused. British Journal of Dermatology 2007; 156:979 985. Hart HE, Redekop WK, Bilo HJ, Meyboom de Jong B, Berg M. Health related quality of life in patients with type I diabetes mellitus: generic & disease specific measurement. Indian Journal of Medical Research 2007; 125:203 216. Hermsen BBJ, Olivier RI, Verheijen RHM, van Beurden M, de Hullu JA, Massuger LF, Burger CW, Brekelmans CT, Mourits MJ, de Bock GH, Gaarenstroom KN, van Boven HH, Mooij TM, Rookus MA. No efficacy of annual gynaecological screening in BRCA1/2 mutation carriers; an observational follow up study. British Journal of Cancer 2007; 96:1335 1342. top-10% article top-30% article

284 Graduate School for Health Research SHARE Self evaluation 2003-2008 Hubben GAA, Bos JM, Glynn DM, van der Ende A, van Alphen L, Postma MJ. Enhanced decision support for policy makers using a web interface to health economic models Illustrated with a cost effectiveness analysis of nation wide infant vaccination with the 7 valent pneumococcal conjugate vaccine in the Netherlands. Vaccine 2007; 25:3669 3678. Jacobs JW, de Nijs RN, Lems WF, Geusens PP, Laan RF, Huisman AM, Algra A, Buskens E, Hofbauer LC, Oostveen AC, Bruyn GA, Dijkmans BA, Bijlsma JW. Prevention of glucocorticoid induced osteoporosis with alendronate or alfacalcidol: relations of change in bone mineral density, bone markers, and calcium homeostasis. Journal of Rheumatology 2007; 34:1051 1057. Jansman FGA, Postma MJ, Brouwers JRBJ. Cost considerations in the treatment of colorectal cancer. Pharmacoeconomics 2007; 25:537 562. Janssen P, Gorter K, Stolk R, Rutten G. Low yield of population based screening for Type 2 diabetes in the Netherlands: the ADDITION Netherlands study. Family Practice 2007; 24:555 561. Keegstra AL, Knijff WA, Post WJ, Goorhuis Brouwer SM. Children with language problems in a speech and hearing clinic: Background variables and extent of language problems. International Journal of Pediatric Otorhinolaryngology 2007; 71:815 821. Keizer D, van Wijhe M, Post WJ, Uges DRA, Wierda JMKH. Assessment of the clinical relevance of quantitative sensory testing with Von Frey monofilaments in patients with allodynia and neuropathic pain. A pilot study. European Journal of Anaesthesiology 2007; 24:658 663. Keizer D, van Wijhe M, Post WJ, Wierda JMKH. Quantifying allodynia in patients suffering from unilateral neuropathic pain using Von Frey monofilaments. Clinical Journal of Pain 2007; 23:85 90. Klaver NS, Kuizenga K, Ballast A, Fidler V. A comparison of the clinical use of the Laryngeal Tube S (TM) and the ProSeal (R) Laryngeal Mask Airway by first month anaesthesia residents in anaesthetised patients. Anaesthesia 2007; 62:723 727. Klazen C, Verhaar H, Lampmann L, Juttmann J, Blonk M, Jansen F, Tielbeek A, Schoemaker M, Buskens E, van der Graaf Y, Janssens X, Fransen H, van Everdingen K, Muller A, Mali W, Lohle P. VERTOS II: Percutaneous vertebroplasty versus conservative therapy in patients with painful osteoporotic vertebral compression fractures; rationale, objectives and design of a multicenter randomized controlled trial. Trials 2007; 8:33. Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom de Jong B, Bilo HJ. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double blind, placebo controlled trial. Diabetes Care 2007; 30:1092 1096. Laan W, Selten JP, Grobbee DE, Smeets H, Kahn RS, Burger H. Non steroidal anti inflammatory drugs and the risk of psychosis. European Neuropsychopharmacology 2007; 17:309 311. Logtenberg SJ, Kleefstra N, Houweling ST, Groenier KH, Bilo HJ. Effect of device guided breathing exercises on blood pressure in hypertensive patients with type 2 diabetes mellitus: a randomized controlled trial. Journal of Hypertension 2007; 25:241 246. Logtenberg SJJ, Kleefstra N, Houweling ST, Groenier KH, Bilo HJG. Device guided slow breathing as a nonpharmacological approach to anti hypertensive treatment in type 2 diabetics Reply. Journal of Hypertension 2007; 25:1742 1743. Meiland R, Stolk RP, Geerlings SE, Peeters PHM, Grobbee DE, Coenjaerts FEJ, Brouwer EC, Hoepelman AIM. Association between Escherichia coli bacteriuria and renal function in women Long term follow up. Archives of Internal Medicine 2007; 167:253 257. Naunton M, Brouwers JRBJ, Duyvendak M. Dose conversions: opportunity for error (letter). American Journal of Medicine 2007; 120:e1. Oonk MHM, de Bock GH, van der Veen DJ, ten Hoor KA, de Hullu JA, Hollema H, van der Zee AGJ. EGFR expression is associated with groin node metastases in vulvar cancer, but does not improve their prediction. Gynecologic Oncology 2007; 104:109 113. Postma MJ, Novak A, Scheijbeler HWKF, Gyldmark M, van Genugten MLL, Wilschut JC. Cost effectiveness of oseltamivir treatment for patients with influenza like illness who are at increased risk for serious complications of influenza Illustration for the Netherlands. Pharmacoeconomics 2007; 25:497 509. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 285 Prinssen M, Buskens E, de Jong SE, Buth J, Mackaay AJ, Sambeek MR, Blankensteijn JD. Cost effectiveness of conventional and endovascular repair of abdominal aortic aneurysms: Results of a randomized trial. Journal of Vascular Surgery 2007; 46:883 890. Reinders MK, Nijdam LC, van Roon EN, Movig KL, Jansen TL, van de Laar MA, Brouwers JR. A simple method for quantification of allopurinol and oxipurinol in human serum by high performance liquid chromatography with UV detection. Journal of Pharmaceutical and Biomedical Analysis 2007; 45:312 317. Reinders MK, van Roon EN, Houtman PM, Brouwers JRBJ, Jansen TLTA. Biochemical effectiveness of allopurinol and allopurinol probenecid in previously benzbromarone treated gout patients. Clinical Rheumatology 2007; 26:1459 1465. Reininga IHF, Wagenmakers R, van den Akker Scheek I, Stant AD, Groothoff JW, Bulstra SK, Zijlstra W, Stevens M. Effectiveness of computer navigated minimally invasive total hip surgery compared to conventional total hip arthroplasty: design of a randomized controlled trial. Bmc Musculoskeletal Disorders 2007; 8. Schoonhoven L, Bousema MT, Buskens E. The prevalence and incidence of pressure ulcers in hospitalised patients in the Netherlands: a prospective inception cohort study. International Journal of Nursing Studies 2007; 44:927 935. Schorr SG, Brouwers JRBJ, Taxis K. Wenn Arzneimittel nicht eingenommen werden der Einfluss verschiedener Antipsychotika auf das Complianceverhalten schizophrener Patienten. Fortschritte der Neurologie Psychiatrie 2007; 75:473 477. Schurink CA, Visscher S, Lucas PJ, van Leeuwen HJ, Buskens E, Hoff RG, Hoepelman AI, Bonten MJ. A Bayesian decision support system for diagnosing ventilator associated pneumonia. Intensive Care Medicine 2007; 33:1379 1386. Selten JP, Wierdsma A, Mulder N, Burger H. Treatment seeking for alcohol and drug use disorders by immigrants to the Netherlands Retrospective, population based, cohort study. Social Psychiatry and Psychiatric Epidemiology 2007; 42:301 306. Stant AD, Buskens E, Jenner JA, Wiersma D, TenVergert EM. Cost effectiveness analysis in severe mental illness: Outcome measures selection. Journal of Mental Health Policy and Economics 2007; 10:101 108. Stewart R, Niessen WJ, Broer J, Snijders TA, Haaijer Ruskamp FM, Meyboom de Jong B. General practitioners reduced benzodiazepine prescriptions in an intervention study: a multilevel application. Journal of Clinical Epidemiology 2007; 60:1076 1084. Stolk RP. Screening for diabetes Targeted screening causes less stress than mass screening, but there is insufficient evidence to advocate either. British Medical Journal 2007; 335:457 458. Stolk RP, Vingerling JR, Cruickshank JK, Hughes AD, Stanton A, Lu JM, Patel A, Thom SAM, Grobbee DE. Rationale and design of the AdRem study: Evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus. Contemporary Clinical Trials 2007; 28:6 17. Sturm H, Austvoll Dahlgren A, Aaserud M, Oxman AD, Ramsay C, Vernby A, Kösters JP. Pharmaceutical policies: effects of financial incentives for prescribers (Review). Cochrane Database of Systematic Reviews 2007;Art. No.: CD006731. Sturm HB, van Gilst WH, Veeger N, Haaijer Ruskamp FM. Prescribing for chronic heart failure in Europe: does the country make the difference? A European survey. Pharmacoepidemiology and Drug Safety 2007; 16:96 103. Tobi H, Faber A, van den Berg PB, Drane JW, de Jong van den Berg LTW. Studying co medication patterns: the impact of definitions. Pharmacoepidemiology and Drug Safety 2007; 16:405 411. van der Horst Schrivers AN, Post WJ, Kema IP, Links TP, Willemse PH, Wymenga ANM, de Vries EG. Persistent low urinary excretion of 5 HIAA is a marker for favourable survival during follow up in patients with disseminated midgut carcinoid tumours. European Journal of Cancer 2007; 43:2651 2657. van der Vegt B, de Roos MAJ, Peterse JL, Patriarca C, Hilkens J, de Bock GH, Wesseling J. The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma. Histopathology 2007; 51:322 335. van Heest F, Finlay I, Otter R, Meyboom de Jong B. The new millennium palliative care project (2000 2003): the impact of specialised GP advisors. British Journal of General Practice 2007; 57:494 496. top-10% article top-30% article

286 Graduate School for Health Research SHARE Self evaluation 2003-2008 van Santvoort HC, Besselink MG, Bollen TL, Buskens E, van Ramshorst B, Gooszen HG. Case matched comparison of the retroperitoneal approach with laparotomy for necrotizing pancreatitis. World Journal of Surgery 2007; 31:1635 1642. Verstappen SM, Jacobs JW, Kruize AA, Ehrlich JC, van Albada Kuipers GA, Verkleij H, Buskens E, Bijlsma JW. Trends in economic consequences of rheumatoid arthritis over two subsequent years. Rheumatology (Oxford) 2007; 46:968 974. Visser E, Pijl YJ, Stolk RP, Neeleman J, Rosmalen JGM. Accident proneness, does it exist? A review and meta analysis. Accident Analysis and Prevention 2007; 39:556 564. Vonkeman HE, Klok RM, Postma MJ, Brouwers JRBJ, van de Laar MAFJ. Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs. Drugs & Aging 2007; 24:681 690. Voorham J, Denig P. Computerized extraction of information on the quality of diabetes care from free text in electronic patient records of general practitioners. Journal of the American Medical Informatics Association 2007; 14:349 354. Wilffert B, Boskma RJ, van der Voort PHJ, Uges DRA, van Roon EN, Brouwers JRBJ. 4 Aminopyridine (fampridine) effectively treats amlodipine poisoning: a case report. Journal of Clinical Pharmacy and Therapeutics 2007; 32:655 657. Zantinge EM, Verhaak PFM, de Bakker DH, Kerssens JJ, van der Meer K, Bensing JM. The workload of general practitioners does not affect their awareness of patients psychological problems. Patient Education and Counseling 2007; 67:93 99. 2 0 0 8 Al Hadithy AF, Wilffert B, Stewart RE, Looman NM, Bruggeman R, Brouwers JR, Matroos GE, van Os J, Hoek HW, van Harten PN. Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African Caribbean inpatients: Differences in association with dopamine and serotonin receptors. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2008; 147B:890 897. Al Hadithy AF, Wilffert B, Bruggeman R, Brouwers JR. The impact of MDR1 polymorphisms on prolactin concentrations in patients treated with risperidone. Progress in Neuropsychopharmacology & Biological Psychiatry 2008; 32:593 594. Assink N, Bergman GJ, Knoester B, Winters JC, Dijkstra PU. Assessment of the cervical range of motion over time, differences between results of the Flock of Birds and the EDI 320: A comparison between an electromagnetic tracking system and an electronic inclinometer. Manual Therapy 2008; 13:450 455. Baas AF, Janssen KJM, Prinssen M, Buskens E, Blankensteijn JD. The Glasgow Aneurysm Score as a tool to predict 30 day and 2 year mortality in the patients from the Dutch Randomized Endovascular Aneurysm Management trial. Journal of Vascular Surgery 2008; 47:277 281. Bakker MK, de Walle HE, de Jong van den Berg LTW. Problem of using cases with genetic anomalies as a reference group in case control studies on drug use and birth defects Reply. Birth defects research Part A, Clinical and Molecular Teratology 2008; 82:175. Bakker MK, Kolling P, van den Berg PB, de Walle HE, de Jong van den Berg LTW. Increase in use of selective serotonin reuptake inhibitors in pregnancy during the last decade, a population based cohort study from The Netherlands. British Journal of Clinical Pharmacology 2008; 65:600 606. Beinema M, Brouwers JRBJ, Schalekamp T, Wilffert B. Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thrombosis and Haemostasis 2008; 100:1052 1057. Besselink MG, van Santvoort HC, Buskens E, Akkermans LM, Gooszen HG. Probiotic prophylaxis in predicted severe acute pancreatitis Reply. Lancet 2008; 372:114. Besselink MGH, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJM, Rosman C, Ploeg RJ, Brink MA, Schaapherder AFM, Dejong CHC, Wahab PJ, van Laarhoven CJHM, van der Harst E, van Eijck CHJ, Cuesta MA, Akkermans LMA, Gooszen HG. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double blind, placebo controlled trial. Lancet 2008; 371:651 659. Biermans MCJ, Elbers GH, Veriieu RA, van der Veen WJ, Zielhuis GA, Robbe PFDV. External validation of EPICON: a grouping system for estimating morbidity rates using electronic medical records. Journal of the American Medical Informatics Association 2008; 15:770 775. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 287 Blaauwbroek R, Tuinier W, Meyboom de Jong B, Kamps WA, Postma A. Shared care by paediatric oncologists and family doctors for long term follow up of adult childhood cancer survivors: a pilot study. Lancet Oncology 2008; 9:232 238. Boersma C, Postma MJ, Visser ST, Atthobari J, de Jong PE, de Jong van den Berg LT, Gansevoort RT. Baseline albuminuria predicts the efficacy of blood pressure lowering drugs in preventing cardiovascular events. British Journal of Clinical Pharmacology 2008; 65:723 732. Bor ASE, Rinkel GJE, Adami J, Koffijberg H, Ekbom A, Buskens E, Blomqvist P, Granath F. Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case control study. Brain 2008; 131:2662 2665. Buskens E. Denying may yet make sense. Archives of Surgery 2008; 143:209. de Bock GH, Jacobi CE, Seynaeve C, Krol Warmerdam EM, Blom J, van Asperen CJ, Cornelisse CJ, Klijn JG, Devilee P, Tollenaar RA, Brekelmans CT, van Houwelingen JC. A family history of breast cancer will not predict female early onset breast cancer in a population based setting. BMC Cancer 2008; 8:art. nr. 203. de Graeff P, Crijns AP, ten Hoor KA, Klip HG, Hollema H, Oien K, Bartlett JM, Wisman GB, de Bock GH, de Vries EG, de Jong S, van der Zee AG. The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer. British Journal of Cancer 2008; 99:341 349. de Jong van den Berg LT. Monitoring of the folic acid supplementation program in the Netherlands. Food and Nutrition Bulletin 2008; 29:S210 S213. de Jong J, van den Berg PB, de Vries TW, de Jong van den Berg LT. Antibiotic drug use of children in the Netherlands from 1999 till 2005. European Journal of Clinical Pharmacologyl 2008; 64:913 919. de Langen J, van Hunsel F, Passier A, de Jong van den Berg L, van Grootheest K. Adverse drug reaction reporting by patients in the Netherlands Three years of experience. Drug Safety 2008; 31:515 524. De Rivecourt M, Kuperus MN, Post WJ, Mulder LJM. Cardiovascular and eye activity measures as indices for momentary changes in mental effort during simulated flight. Ergonomics 2008; 51:1295 1319. De Smedt RH, Jaarsma T, van den Broek SA, Haaijer Ruskamp FM. Decompensation of chronic heart failure associated with pregabalin in a 73 year old patient with postherpetic neuralgia: a case report. British Journal of Clinical Pharmacology 2008; 66:327 328. de Vries R, Daenen S, Tolley K, Glasmacher A, Prentice A, Howells S, Christopherson H, de Jong van den Berg LT, Postma MJ. Cost effectiveness of itraconazole in the prophylaxis of invasive fungal infections. Pharmacoeconomics 2008; 26:75 90. de Vries R, van Bergen JE, de Jong van den Berg LT, Postma MJ. Cost utility of repeated screening for Chlamydia trachomatis. Value in Health 2008; 11:272 274. de Walle HE, de Jong van den Berg LT. Ten years after the Dutch public health campaign on folic acid: the continuing challenge. European Journal of Clinical Pharmacology 2008; 64:539 543. Deschepper R, Grigoryan L, Lundborg CS, Hofstede G, Cohen J, Kelen GV, Deliens L, Haaijer Ruskamp FM. Are cultural dimensions relevant for explaining cross national differences in antibiotic use in Europe? BMC Health Services Research 2008; 8:art. nr. 123. Dobre D, de Jongste MJ, Haaijer Ruskamp FM, Sanderman R, van Veldhuisen DJ, Ranchor AV. The enigma of quality of life in patients with heart failure. International Journal of Cardiology 2008; 125:409. Dolk H, Jentink J, Loane M, Morris J, de Jong van den Berg LT. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008; 71:714 722. Duiverman ML, Wempe JB, Bladder G, Jansen DF, Kerstjens HAM, Zijlstra JG, Wijkstra PJ. Nocturnal non invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD. Thorax 2008; 63:1052 1057. Duyvendak M, Naunton M, van Roon EN, Bruyn GAW, Brouwers JRBJ. Systematic review of trends in prophylaxis of corticosteroid induced osteoporosis: the need for standard audit guidelines. Osteoporosis International 2008; 19:1379 1394. top-10% article top-30% article

288 Graduate School for Health Research SHARE Self evaluation 2003-2008 Faber A, van Agthoven M, Kalverdijk LJ, Tobi H, de Jong van den Berg LT, Annemans L, Postma MJ. Long acting methylphenidate OROS in youths with attention deficit hyperactivity disorder suboptimally controlled with immediate release methylphenidate : a study of cost effectiveness in the Netherlands. CNS Drugs 2008; 22:157 170. Foster JM, Sanderman R, van der Molen T, Mueller T, van Sonderen E. Personality influences the reporting of side effects of inhaled corticosteroids in asthma patients. Journal of Asthma 2008; 45:664 669. Gallivan S, Taxis K, Dean FB, Barber N. Is the principle of a stable heinrich ratio a myth? : a multimethod analysis. Drug Safety 2008; 31:637 642. Geluk CA, Post WJ, Hillege HL, Tio RA, Tijssen JG, van Dijk RB, Dijk WA, Bakker SJ, de Jong PE, van Gilst WH, Zijlstra F. C reactive protein and angiographic characteristics of stable and unstable coronary artery disease: data from the prospective PREVEND cohort. Atherosclerosis 2008; 196:372 382. Gerrits EG, Lutgers HL, Kleefstra N, Graaff R, Groenier KH, Smit AJ, Gans RO, Bilo HJ. Skin autofluorescence A tool to identify type 2 diabetic patients at risk for developing microvascular complications. Diabetes Care 2008; 31:517 521. Gibcus JH, Mastik MF, Menkema L, de Bock GH, Kluin PM, Schuuring E, van der Wal JE. Cortactin expression predicts poor survival in laryngeal carcinoma. British Journal of Cancer 2008; 98:950 955. Greving JP, Buskens E, Koffijberg H, Algra A. Cost effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular risk. Circulation 2008; 117:2875 2883. Grigoryan L, Burgerhof JGM, Degener JE, Deschepper R, Lundborg CS, Monnet DL, Scicluna EA, Birkin J, Haaijer Ruskamp FM. Determinants of self medication with antibiotics in Europe: the impact of beliefs, country wealth and the healthcare system. Journal of Antimicrobial Chemotherapy 2008; 61:1172 1179. Haadsma ML, Groen H, Fidler V, Bukman A, Roeloffzen EM, Groenewoud ER, Broekmans FJ, Heineman MJ, Hoek A. The predictive value of ovarian reserve tests for spontaneous pregnancy in subfertile ovulatory women. Human Reproduction 2008; 23:1800 1807. Halbesma N, Brantsma AH, Bakker SJL, Jansen DF, Stolk RP, de Zeeuw D, de Jong PE, Gansevoort RT. Gender differences in predictors of the decline of renal function in the general population. Kidney International 2008; 74:505 512. Heeg BMS, Antunes J, Figueira ML, Jara JM, Teixeira JM, Palha AP, Serra AV, Buskens E, Caleo S, Gouveia Pinto C, van Hout BA. Cost effectiveness and budget impact of long acting risperidone in Portugal: a modeling exercise. Current Medical Research and Opinion 2008; 24:349 358. Heeg BMS, Damen J, Buskens E, Caleo S, Frank dc, Hout BA. Modelling approaches : the case of schizophrenia. Pharmacoeconomics 2008; 26:633 648. Heisterkamp SH, de Vries R, Sprenger HG, Hubben GAA, Postma MJ. Comment on Estimation and prediction of the HIV AIDS epidemic under conditions of HAART using mixtures of incubation time distributions. Statistics in Medicine 2008; 27:2035 2036. Heisterkamp SH, de Vries R, Sprenger HG, Hubben GAA, Postma MJ. Estimation and prediction of the HIV AIDS epidemic under conditions of HAART using mixtures of incubation time distributions. Statistics in Medicine 2008; 27:781 794. Hubben GAA, Bishai D, Pechlivanoglou P, Cattelan AM, Grisetti R, Facchin C, Compostella FA, Bos JM, Postma MJ, Tramarin A. The societal burden of HIV/AIDS in Northern Italy: An analysis of costs and quality of life. AIDS Care 2008; 20:449 455. Janssen MP, de Borst GJ, Mali WPTM, Kappelle LJ, Moll FL, Ackerstaff RGA, Rothwell PM, Brown MM, van Sambeek MR, Buskens E. Carotid stenting versus carotid endarterectomy: Evidence basis and cost implications. European Journal of Vascular and Endovascular Surgery 2008; 36:258 264. Janssen PGH, Gorter KJ, Stolk RP, Rutten GEHM. Do characteristics of practices and general practitioners influence the yield of diabetes screening in primary care? The ADDITION Netherlands study. Scandinavian Journal of Primary Health Care 2008; 26:160 165. Jentink J, van de Vrie Hoekstra NW, de Jong van den Berg LT, Postma MJ. Economic evaluation of folic acid food fortification in The Netherlands. European Journal of Public Health 2008; 18:270 274. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 289 Kalverdijk LJ, Tobi H, van den Berg PB, Buiskool J, Wagenaar L, Minderaa RB, de Jong van den Berg LTW. Use of antipsychotic drugs among dutch youths between 1997 and 2005. Psychiatric Services 2008; 59:554 560. Kelder W, Inberg B, Plukker JTM, Groen H, Baas PC, Tiebosch ATMG. Effect of modified Davidson s fixative on examined number of lymph nodes and TNM stage in colon carcinoma. EJSO 2008; 34:525 530. Kleefstra N, Houweling ST, Groenier KH, Bilo HJG. Author reply: phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation. Metabolism Clinical and Experimental 2008; 57:1623 1624. Kleefstra N, Landman GWD, Houweling ST, Ubink Veltmaat LJ, Logtenberg SJJ, Meyboom de Jong B, Coyne JC, Groenier KH, Bilo HJG. Prediction of mortality in type 2 diabetes from health related quality of life (ZODIAC 4). Diabetes Care 2008; 31:932 933. Koffijberg H, Buskens E, Algra A, Wermer MJ, Rinkel GJ. Growth rates of intracranial aneurysms: exploring constancy. Journal of Neurosurgery 2008; 109:176 185. Koffijberg H, Buskens E, Algra A, Wermer MJH, Rinkel GJE. Assessing the constancy of intracranial aneurysm growth rates Response. Journal of Neurosurgery 2008; 109:174 175. Koffijberg H, Buskens E, Granath F, Adami J, Ekbom A, Rinkel GJE, Blomqvist P. Subarachnoid haemorrhage in Sweden 1987 2002: regional incidence and case fatality rates. Journal of Neurology Neurosurgery and Psychiatry 2008; 79:294 299. Kooij JS, Boonstra AM, Vermeulen SH, Heister AG, Burger H, Buitelaar JK, Franke B. Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2008; 147B:201 208. L Abee C, Sauer PJ, Damen M, Rake JP, Cats H, Stolk RP. Cohort Profile: the GECKO Drenthe study, overweight programming during early childhood. International Journal of Epidemiology 2008; 37:486 489. Liem ET, Sauer PJ, Oldehinkel AJ, Stolk RP. Association between depressive symptoms in childhood and adolescence and overweight in later life: review of the recent literature. Archives of Pediatrics and Adolescent Medicine 2008; 162:981 988. Martirosyan L, Braspenning J, Denig P, de Grauw WJ, Bouma M, Storms F, Haaijer Ruskamp FM. Prescribing quality indicators of type 2 diabetes mellitus ambulatory care. Quality & Safety in Health Care 2008; 17:318 323. Meex SJR, van Vliet Ostaptchouk JV, van der Kallen CJH, van Greevenbroek MMJ, Schalkwijk CG, Feskens EJM, Blaak EE, Wijmenga C, Hofker MH, Stehouwer CDA, de Bruin TWA. Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians. Molecular Genetics and Metabolism 2008; 94:352 355. Mulder J, Groenier KH, Dekker JH, Berendsen AJ, Schuling J. Is there a need for a GP consultant at a university hospital? BMC Family Practice 2008; 9. Penninx BWJH, Beekman ATF, Smit JH, Zitman FG, Nolen WA, Spinhoven P, Cuijpers P, de Jong PJ, van Marwijk HWJ, Assendelft WJJ, van der Meer K, Verhaak P, Wensing M, de Graaf R, Hoogendijk WJ, Ormel J, van Dyck R. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. International Journal of Methods in Psychiatric Research 2008; 17:121 140. Peters Veluthamaningal C, Winters JC, Groenier KH, Meyboom de Jong B. Corticosteroid injections effective for trigger finger in adults in general practice: a double blinded randomised placebo controlled trial. Annals of the Rheumatic Diseases 2008; 67:1262 1266. Postma MJ, de Vries R, Welte R, Edmunds WJ. Health economic methodology illustrated with recent work on Chlamydia screening: the concept of extended dominance. Sexually Transmitted Infections 2008; 84:152 154. Postma MJ, Boersma C, Gansevoort RT. Pharmacoeconomics in nephrology: considerations on cost effectiveness of screening for albuminuria. Nephrology Dialysis Transplantation 2008; 23:1103 1106. Prins MA, Verhaak PFM, Bensing JM, van der Meer K. Health beliefs and perceived need for mental health care of anxiety and depression The patients perspective explored. Clinical Psychology Review 2008; 28:1038 1058. top-10% article top-30% article

290 Graduate School for Health Research SHARE Self evaluation 2003-2008 Pultrum BB, van Bastelaar J, Schreurs LMA, van Dullemen HM, Groen H, Nijsten MWN, van Dam GM, Plukker JTHM. Impact of splenectomy on surgical outcome in patients with cancer of the distal esophagus and gastro esophageal junction. Diseases of the Esophagus 2008; 21:334 339. Rozenbaum MH, Verweel G, Folkerts DKF, Dronkers F, van den Hoek JAR, Hartwig NG, de Groot R, Postma MJ. Cost effectiveness estimates for antenatal HIV testing in the Netherlands. International Journal of Std & Aids 2008; 19:668 675. Rozenbaum MH, van Hoek AJ, Vegter S, Postma MJ. Cost effectiveness of varicella vaccination programs: an update of the literature. Expert Review of Vaccines 2008; 7:753 782. Sancar AA, Yegenoglu S, de Vries R, Postma MJ, Simsek N, Pechlivanoglou P, Unal S. Vancomycin vs teicoplanin in the treatment of Gram positive infections: a pharmacoeconomic analysis in a Turkish University Hospital. Pharmacy World & Science 2008; 30:916 923. Sandbaek A, Griffin SJ, Rutten G, Davies M, Stolk R, Khunti K, Borch Johnsen K, Wareham NJ, Lauritzen T. Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study. Diabetologia 2008; 51:1127 1134. Schneeberger C, Stolk RP, Devries JH, Schneeberger PM, Herings RM, Geerlings SE. Differences in the pattern of antibiotic prescription profile and recurrence rate for possible urinary tract infections in women with and without diabetes. Diabetes Care 2008; 31:1380 1385. Schorr SG, Slooff CJ, Postema R, van Oven W, Schilthuis M, Bruggeman R, Taxis K. A 12 month follow up study of treating overweight schizophrenic patients with aripiprazole. Acta Psychiatrica Scandinavica 2008; 118:246 250. Schorr SG, Loonen AJ, Brouwers JR, Taxis K. A cross sectional study of prescribing patterns in chronic psychiatric patients living in sheltered housing facilities. International Journal of Clinical Pharmacology and Therapeutics 2008; 46:146 150. Schreurs LM, Verhoef CC, van der Jagt EJ, van Dam GM, Groen H, Plukker JT. Current relevance of cervical ultrasonography in staging cancer of the esophagus and gastroesophageal junction. European Journal of Radiology 2008; 67:105 111. Schreurs LM, Pultrum BB, Koopmans KP, Verhoef CC, Jager PL, van Dam GM, Groen H, van der Jagt EJ, Plukker JTM. Better assessment of nodal metastases by PET/CT fusion compared to side by side PET/CT in oesophageal cancer. Anticancer Research 2008; 28:1867 1873. Schrijvers ML, van der Laan BF, de Bock GH, Pattje WJ, Mastik MF, Menkema L, Langendijk JA, Kluin PM, Schuuring E, van der Wal JE. Overexpression of intrinsic hypoxia markers HIF1alpha and CA IX predict for local recurrence in stage T1 T2 glottic laryngeal carcinoma treated with radiotherapy. International Journal of Radiation Oncology, Biology, Physics 2008; 72:161 169. Siemonsma PC, Schroder CD, Dekker JH, Lettinga AT. The benefits of theory for clinical practice: cognitive treatment for chronic low back pain patients as an illustrative example. Disability and Rehabilitation 2008; 30:1309 1317. Smink BE, Hofman BJ, Dijkhuizen A, Lusthof KJ, de Gier JJ, Egberts AC, Uges DR. The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam. British Journal of Clinical Pharmacology 2008; 66:556 560. Snieder H, Wang X, Shiri Sverdlov R, van Vliet Ostaptchouk JV, Hofker MH, Perks U, Spector TD, O Dell SD. TUB is a candidate gene for late onset obesity in women. Diabetologia 2008; 51:54 61. Stadhouder A, Buskens E, de Klerk LW, Verhaar JA, Dhert WA, Verbout AJ, Vaccaro AR, Oner FC. Traumatic thoracic and lumbar spinal fractures: Operative or nonoperative treatment Comparison of two treatment strategies by means of surgeon equipoise. Spine 2008; 33:1006 1017. Stolk RP, Rosmalen JGM, Postma DS, de Boer RA, Navis G, Slaets JPJ, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases LifeLines: a three generation population based study. European Journal of Epidemiology 2008; 23:67 74. Stolk RP, van Schooneveld MJ, Cruickshank JK, Hughes AD, Stanton A, Lu J, Patel A, Thom SA, Grobbee DE, Vingerling JR. Retinal vascular lesions in patients with type 2 diabetes mellitus of Caucasian and Asian origin baseline results from the AdRem study. Diabetes Care 2008; 31:708 713. ter Horst PG, Jansman FG, van Lingen RA, Smit JP, de Jong van den Berg LT, Brouwers JR. Pharmacological aspects of neonatal antidepressant withdrawal. Obstetrical & Gynecological Survey 2008; 63:267 279. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 291 Tramarin A, Gennaro N, Compostella FA, Gallo C, Wendelaar Bonga LJ, Postma MJ. HCV screening to enable early treatment of hepatitis C : a mathematical model to analyse costs and outcomes in two populations. Current Pharmaceutical Design 2008; 14:1655 1660. van Bruggen R, Gorter KJ, Stolk RP, Verhoeven RP, Rutten GEHM. Implementation of locally adapted guidelines on type 2 diabetes. Family Practice 2008; 25:430 437. van Bruggen R, Gorter K, Stolk R, Zuithoff P, Verhoeven R, Rutten G. Overall quality of diabetes care in a defined geographic region: different sides of the same story. British Journal of General Practice 2008; 58:339 345. van de Vrie Hoekstra NW, de Vries TW, van den Berg PB, Brouwer OF, de Jong van den Berg LT. Antiepileptic drug utilization in children from 1997 2005 a study from the Netherlands. European Journal of Clinical Pharmacology 2008; 64:1013 1020. van der Stege JG, Groen H, van Zadelhoff SJN, Lambalk CB, Braat DDM, van Kasteren YM, van Santbrink EJP, Apperloo MJA, Schultz WCMW, Hoek A. Decreased androgen concentrations and diminished general and sexual well being in women with premature ovarian failure. Menopause the Journal of the North American Menopause Society 2008; 15:23 31. van Doormaal JE, Mol PG, van den Bemt PM, Zaal RJ, Egberts AC, Kosterink JG, Haaijer Ruskamp FM. Reliability of the assessment of preventable adverse drug events in daily clinical practice. Pharmacoepidemiology and Drug Safety 2008; 17:645 654. van Hecke MV, Dekker JM, Nijpels G, Teerlink T, Jakobs C, Stolk RP, Heine RJ, Bouter LM, Polak BC, Stehouwer CD. Homocysteine, S adenosylmethionine and S adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study. Clinical Science (Lond) 2008; 114:479 487. van Hulst M, Sagoe KWC, Vermande JE, van der Schaaf IP, Adriani WPAV, Torpey K, Ansah J, Mingle JAA, Sibinga CTS, Postma MJ. Cost effectiveness of HIV screening of blood donations in Accra (Ghana). Value in Health 2008; 11:809 819. van Os Medendorp H, Guikers CLH, Eland de Kok PCM, Ros WJG, Bruijnzeel Koomen CAFM, Buskens E. Costs and cost effectiveness of the nursing programme Coping with itch for patients with chronic pruritic skin disease. British Journal of Dermatology 2008; 158:1013 1021. van Roest MHG, Gouw ASH, Peeters PMJG, Porte RJ, Slooff MJH, Fidler V, de Jong KP. Results of pancreaticoduodenectomy in patients with periampullary adenocarcinorna Perineural growth more important prognostic factor than tumor localization. Annals of Surgery 2008; 248:97 103. van Vliet Ostaptchouk JV, Onland Moret NC, van Haeften TW, Franke L, Elbers CC, Shiri Sverdlov R, van der Schouw YT, Hofker MH, Wijmenga C. HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics 2008; 16:652 656. Vegter S, de Jong van den Berg LTW. Choice of first antihypertensive comparison between the Irish and Dutch setting. British Journal of Clinical Pharmacology 2008; 66:315. Vegter S, Boersma C, Rozenbaum M, Wilffert B, Navis G, Postma MJ. Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines. Pharmacoeconomics 2008; 26:569 587. Vehof J, Postma MJ, Bruggeman R, de Jong van den Berg LTW, van den Berg PD, Stolk RP, Burger H. Predictors for starting depot administration of risperidone in chronic users of antipsychotics. Journal of Clinical Psychopharmacology 2008; 28:625 630. Verduin PJM, de Bock GH, Vlieland TPMV, Peeters AJ, Verhoef J, Otten W. Purpose in life in patients with rheumatoid arthritis. Clinical Rheumatology 2008; 27:899 908. Verhoeven EL, Kapma MR, Groen H, Tielliu IF, Zeebregts CJ, Bekkema F, van den Dungen JJ. Mortality of ruptured abdominal aortic aneurysm treated with open or endovascular repair. Journal of Vascular Surgery 2008; 48:1396 1400. Vlieg Boerstra BJ, Dubois AEJ, van der Heide S, Bijleveld CMA, Wolt Plompen SAA, Elberink JNGO, Kukler J, Jansen DF, Venter C, Duiverman EJ. Ready to use introduction schedules for first exposure to allergenic foods in children at home. Allergy 2008; 63:903 909. top-10% article top-30% article

292 Graduate School for Health Research SHARE Self evaluation 2003-2008 Vonkeman HE, Braakman Jansen LMA, Klok RM, Postma MJ, Brouwers JRBJ, van de Laar MAFJ. Incremental cost effectiveness of proton pump inhibitors for the prevention of non steroidal anti inflammatory drug ulcers: a pharmacoeconomic analysis linked to a case control study. Arthritis Research & Therapy 2008; 10:Art No R144. Voorham J, Haaijer Ruskamp FM, Stolk RP, Wolffenbuttel BH, Denig P. Influence of elevated cardiometabolic risk factor levels on treatment changes in type 2 diabetes. Diabetes Care 2008; 31:501 503. Voorham J, Denig P, Wolffenbuttel BH, Haaijer Ruskamp FM. Cross sectional versus sequential quality indicators of risk factor management in patients with Type 2 diabetes. Medical Care 2008; 46:133 141. Vroom F, van de Laar MAJF, van Roon EN, Brouwers JRBJ, de Jong van den Berg LTW. Treatment of pregnant and non pregnant rheumatic patients: a survey among Dutch rheumatologists. Journal of Clinical Pharmacy and Therapeutics 2008; 33:39 44. Vroom F, van Roon EN, van den Berg PB, Brouwers JR, de Jong van den Berg LT. Prescribing of sulfasalazine, azathioprine and methotrexate round pregnancy a descriptive study. Pharmacoepidemiology and Drug Safety 2008; 17:52 61. Wang Y, van Klaveren RJ, van der Zaag Loonen HJ, de Bock GH, Gietema HA, Xu DM, Leusveld AL, de Koning HJ, Scholten ET, Verschakelen J, Prokop M, Oudkerk M. Effect of nodule characteristics on variability of semiautomated volume measurements in pulmonary nodules detected in a lung cancer screening program. Radiology 2008; 248:625 631. Weidenaar AC, de Jonge HJM, Fidler V, ter Elst A, Meeuwsen de Boer T, Douwes J, Bouma ter Steege JCA, Hahlen K, Kamps WA, de Bont ESJM. Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death. Anti Cancer Drugs 2008; 19:45 54. Xu DM, van Klaveren RJ, de Bock GH, Leusveld A, Zhao Y, Wang Y, Vliegenthart R, de Koning HJ, Scholten ET, Verschakelen J, Prokop M, Oudkerk M. Limited value of shape, margin and CT density in the discrimination between benign and malignant screen detected solid pulmonary nodules of the NELSON trial. European Journal of Radiology 2008; 68:347 352. Zijlmans M, Buskens E, Hersevoort M, Huiskamp G, van Huffelen AC, Leijten FSS. Should we reconsider epilepsy surgery? The motivation of patients once rejected. Seizure European Journal of Epilepsy 2008; 17:374 377. Re f e r e e d a r t i c l e s i n n o n I S I j o u r n a l s 2 0 0 3 Annemans L, Bos JM, Postma MJ. Discounting health effects in pharmacoeconomic evaluations: some additional elements to consider. ISPOR Connections 2003; 9:3 7. Brouwers JRBJ. Pharmaceutical care in Dutch Hospitals. European Journal of Hospital Pharmacy 2003; 3:56. Brouwers JRBJ. Farmacotherapie van benigne prostaathyperplasie. Pharmaceutisch Weekblad 2003; 138:1403 1406. de Gier JJ. Financing pharmaceutcial care in the dutch health care system. Journal of Pharmaceutical Finance, Economics & Policy 2003; 12:181 188. Denig P, Kasje WN, Haaijer Ruskamp FM. Willen artsen wel (transmurale) richtlijnen? Succes en faalfactoren voor implementatie in de praktijk. Pharmaceutisch Weekblad 2003; 138:1728. Denig P, Onnes B, Haaijer Ruskamp FM. Verbetering blijft nog uit; effect van een FTO programma over astma op kwaliteit van leven bij patiënten. Pharmaceutisch Weekblad 2003; 138:1276 1281. Hiddema van der Wal A, van der Werf GTh, Meyboom de Jong B. Welke ICPC codes willen huisartsen automatisch laten toevoegen aan de probleemlijst? Huisarts en Wetenschap 2003; 46:539 543. Kleefstra N, Houweling ST, Bilo HJG. Hepatitis yes, but toxic effect of chromium? European Journal of Internal Medicine 2003; 14:136 137. Kluiver EP, Ottervanger JP, Meyboom de Jong B, Zijlstra F, Remkes PAJ, Casparie AF. Vrije toegang van de huisarts tot inspanningselektrocardiografie: een gecontroleerd onderzoek. Huisarts en Wetenschap 2003; 46:807 813. top-10% article top-30% article

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 293 Oppewal F, Meyboom de Jong B. Overwegingen van huisartsen bij het niet aanvragen van obductie; een verslag van drie focusgroepen. Nederlands Tijdschrift voor Geneeskunde 2003; 147:1315 1318. Oud MJT, Schaafsma RH, Schuling J. Accuracy of electronic patient record registration in chronic psychosis. European Journal of General Practice 2003; 9:154 155. Postma MJ, Heijen M LA, Beutels PH, Jager JC. Pharmacoeconomics of elderly vaccination against invasive pneumococcal infections: cost effectiverness analysis and implications for The Netherlands. Expert Review of Vaccines 2003; 2:477 482. Postma MJ, Kruidhof H, de Jong van den Berg LTW, de Zeeuw D. Pharmacoeconomic aspects of losartan treatment to delay progression of renal disease in patients with type 2 diabetes (vol 4, pg 1543, 2003). Expert Opinion on Pharmacotherapy 2003; 4:1887. Spijker Huiges A, Winters JC, Meyboom de Jong B. Chronische maagzuurremmers slikken of stoppen? Een overzicht van de literatuur. Huisarts en Wetenschap 2003; 46:746 749. Tiwari R, Brouwer J, Quak J, Tobi H, Mehta D. Squamous cell carcinoma of the external auditory canal and middle ear. Results of treatment with subtotal temporal bone resection and postoperative radiotherapy. Indian Journal of Otolaryngology and Heck and Neck Surgery 2003; 54:179 183. van der Veen WJ, van der Meer K. Stroke services; policy and practice across Europe (book review). International Journal of Integrated Care 2003; 3. van der Veen WJ. De kleine epidemiologische transitie: verdere daling van de zuigelingensterfte door medische interventie rond zwangerschap en bevalling, maar geen daling van handicaps op de kinderleeftijd. Nederlands Tijdschrift voor Geneeskunde 2003; 147:378 381. van der Werf GTh, Veehof LJG. Huisartspraktijk en academie. De geschiedenis van de groepspraktijk. Huisarts en Wetenschap 2003; 46:680 684. van der Werf GTh, Groenhof G, van der Veen WJ. Comorbiditeit en comedicatie bij patiënten met boezemfibrilleren. Huisarts en Wetenschap 2003; 46:813 818. van Heest FB, Meyboom de Jong B, Otter R. Consultatieve palliatieve zorg bij misselijkheid en braken in de thuissituatie. Nederlands Tijdschrift voor Geneeskunde 2003; 147:1297 1300. Verhoeven AAH, Schuling J. Op zoek naar bewijs; een vraag en antwoorddienst voor de huisarts. Huisarts en Wetenschap 2003; 46:12 16. Wieringa N, Denig P, de Graeff P, Vos R, van der Werf G. Patiënten in geneesmiddelenonderzoek verschillen van latere gebruikers. Huisarts en Wetenschap 2003; 46:750 753. 2 0 0 4 Ajubi NE, Al Hadithy AFY, Brouwers JRBJ, Storm H, Wilffert B. Determination of dopamine receptor(d2) 141C Ins/Del polymorphism in whole blood and buccal swabs by PCR RFLP genotyping using GC Rich solution. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 2004; 29:263 265. Al Hadithy AFY, de Boer NHK, Derijks LJJ, Brouwers JRBJ. Individualisering van therapie bij inflammatoire darmziekten: farmacogenetica en bloedspiegelbepalingen bij thiopurines. Pharmaceutisch Weekblad 2004; 139:1744 1747. Baarveld F, ter Steege MJD, van Ernst GC. Van huisarts naar sportarts: een onderzoek naar het verwijspatroon van sportgerelateerde problemen. Sport en Geneeskunde 2004; 37:64 68. Baarveld F. Preventie van sportgerelateerde problemen: een taak voor de huisarts? TSG: Tijdschrift voor Sociale Gezondheidszorg 2004; 82:285 289. Bos JM, Postma MJ. Using pharmacoeconomics for policy making: is rational decision making enhanced by applying thresholds for cost effectiveness? Expert Review of Pharmacoeconomics & Outcomes Research 2004; 4:127 130. Botta Steeneken NA, van Roon EN, Janssen TLTA, Keuper R, Wu MD, Brouwers JRBJ. Optimalisering van leflunomide therapie. Pharmaceutisch Weekblad 2004; 139:978 981. Brouwers JMM, Briet JM, Brouwers JRBJ. Weeënstorm na cervixrijping met dinoproston in een vaginaal afgiftesysteem. Nederlands Tijdschrift voor Geneeskunde 2004; 148:1300 1303.

294 Graduate School for Health Research SHARE Self evaluation 2003-2008 Brouwers JRBJ. Stability of sufentanil citrate and sufentanil citrate/bupivacaine mixture in portable infusion pump reservoirs. European Journal of Hospital Pharmacy Science 2004; 6:78. Brouwers JRBJ, Harting JW, van Duilemen HM. Handvatten voor de selectie van protonpompremmers. Pharmaceutisch Weekblad 2004; 139:1382 1387. Brouwers JRBJ, van Luin M. Off label gebruik en uitwisselbaarheid van NSAIDs. Pharmaceutisch Weekblad 2004; 139:910 911. de Gier JJ. Categorization of effects of medicinal drugs on skilled performance: an international approach. International Pharmacy Journal 2004; 18:31 33. de Gier JJ. Trend watching for pharmacy information. International Pharmacy Journal 2004; 18:13 14. Erdmann H, Heinemann D, Hoppe Tichy T, Reissner P, Schnurrer JU, Taxis K. Drug safety is at risk by unclear dosage instructions. Krankenhauspharmazie 2004; 25:497. Fijn R, Lenderink AW, Egberts ACG, Brouwers JRBJ, de Jong van den Berg LTW. Farmaco epidemiologisch model levert indicatoren voor non conform voorschrijfgedrag. Pharmaceutisch Weekblad 2004; 139:1550 1553. Frankhuisen R, Brouwers JRBJ. Antacida in de zwangerschap: welke zijn het veiligst? Modern Medicine 2004; 9:47 51. Frankhuisen R, Brouwers JRBJ, Otten MH, Croonen HF. Aluminiumbevattende antacida niet veilig tijdens zwangerschap. Pharmaceutisch Weekblad 2004; 139:1355 1357. Frijlink HW, Lebrun P, Brouwers JRBJ. Farmacokinetiek en toedieningsvormen. Pharmaceutisch Weekblad 2004; 139:921 926. Horst Schrivers AN, Ubink Veltmaat LJ, van der Horst IC, Bilo HJ, Lambert J. Matige bloeddrukregulatie bij patienten met diabetes mellitus type 2 in de eerste en tweede lijn. Nederlands Tijdschrift voor Geneeskunde 2004; 148:570 574. Jansman FGA, Jansen JA, Coenen JLL, de Graaf JC, Smit WM, Brouwers JRBJ. Klinisch relevante interactiesvan fluorouracil +leucovorine bij patiënten met colorectaal kanker. Pharmaceutisch Weekblad 2004; 139:1392 1396. Kleefstra N, Bilo HJ, Bakker SJ, Houweling ST. Chroom en insulineresistentie. Nederlands Tijdschrift voor Geneeskunde 2004; 148:217 220. Klok RM, Postma MJ. Four quadrants of the cost effectiveness plane: some considertations on the south west quadrant. Expert Review of Pharmacoeconomics & Outcomes Research 2004; 4:599 601. Lems WF, Samson M, Brouwers JRBJ, Hamdy NAT, Mulder CJJ, Schobben AFAM, Jutman JR, Bijlsma JWJ. Gastro intestinale tolerantie van bisfosfonaten. Nederlands Tijdschrift Reumatologie 2004; 7:47 51. Meijer WM, de Smit DJ, Jurgens RA, de Jong van den Berg LTW. Pharmacists role in improving awareness about folic acid: a pilot study on the process of introducing an intervention in pharmacy practice. International Journal of Pharmacy Practice 2004; 12:29 35. Oppewal F, Meyboom de Jong B. Mortality in general practice an analysis of 841 deaths during a two year period in 17 Dutch practices. European Journal of General Practice 2004; 10:13 17. Oppewal F, Smedts F, Meyboom de Jong B. Obductie als laatste verwijzing vanuit de huisartsenpraktijk. Huisarts en Wetenschap 2004; 47:408. Postma M, Jansen LMA, Brouwers JRBJ. Bruggen bouwen tussen vergoedingsbeleid en farmaco economisch onderzoek. Pharmaceutisch Weekblad 2004; 139:257 259. Postma MJ, Bos JM, Welte R, de Groot R, Luytjes W, Rümke HC, Beutels P. Do costs of varicella justify routine infant vaccination? European Journal of Health Economics 2004; 1:54 57. Postma MJ, Sagoe KWC, Dronkers F, Sprenger HG, de Jong van den Berg LTW, Beck EJ. Cost effectiveness of antenatal HIV testing: reviewing its pharmaceutical and methodological aspects. Expert Opinion on Pharmacotherapy 2004; 5:521 528. Reinders MK, van Roon EN, Brouwers JRBJ, Jansen TLTA. Effectiviteit van allopurinol en benzbromaron bij gecompliceerde jicht. Pharmaceutisch Weekblad 2004; 139:1710 1713.

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 295 Sramkova P, de Jong van den Berg LTW, Oerlemans APWM. Comparison of Dutch and Czech systems of pharmacy studies. Pharmacy Education 2004; 4:153 163. Taxis K. Medikationsfehler in deutschen Krankenhäusern. Krankenhauspharmazie 2004; 25:465 470. Taxis K, Barber N. Causes of intravenous medication errors observation of nurses in a German hospital. Journal of Public Health 2004; 12:132 138. Terluin B, van Hout HPJ, van Marwijk HW, Ader HJ, van der Meer K, de Haan M, van Dyck R. Diagnose depressie niet zo betrouwbaar te stellen. Huisarts en Wetenschap 2004; 47:66 69. Ubink Veltmaat LJ, Bilo HJ, Meyboom de Jong B. Microalbuminurie bij patienten met diabetes mellitus type 2 in de huisartspraktijk. Nederlands Tijdschrift voor Geneeskunde 2004; 148:2026 2030. van der Werf JJ, Dekens Konter J, Brouwers JRBJ. A new model for teaching pharmaceutical care services. Pharmacy Education 2004; 4:165 169. van Grootheest AC, de Jong van den Berg LTW. Patient s role in reporting adverse drug reactions. Expert Opinion on Drug Safety 2004; 3:363 368. van Hulst M, Slappendel R, Postma MJ. The pharmacoeconomics of alternatives to allogeneic blood transfusion. Transfusion Alternatives in Transfusion Medicine 2004; 6:29 36. Verhoeven AA, Schuling J. Effect of an evidence based answering service on GPs and their patients: a pilot study. Health Information and Libraries Journal 2004; 21 Suppl 2:27 35. Wachters Kaufmann CSM, Schuling J. Voorlichting na een beroerte: fasering en samenhang. Nederlands Tijdschrift voor Geneeskunde 2004; 148:4 6. Walsh JM, de Gier JJ, Christophersen AS, Verstraete A. Drugs and driving. Traffic Injury Prevention 2004; 5:241 253. Zijlstra GS, Boersma C, Frijlink HW, Postma MJ. Pharmacoeconomic review of recombinant human DNase in the management of cystic fibrosis. Expert Review of Pharmacoeconomics & Outcomes Research 2004; 4:49 59. 2 0 0 5 Al Hadithy AFY, Naunton M, Brouwers JRBJ. Thiopurines for inflammatory bowel disease: role of pharmacogenetics. journal of Pharmacy Practice and Research 2005; 35:213 215. Bergman GJD, Winters JC, Groenier KH, Pool JJM, Meyboom de Jong B, Postema K, van der Heijden GJMG. Aanvullende manuele therapie bij patiënten met schouderklachten. Huisarts en Wetenschap 2005; 48:438 443. Boersma C, Klok RM, Bos JM, Naunton M, van de Berg PB, de Jong van den Berg LTW. Drug costs developments after patent expiry of enalapril, fluoxetine and ranitidine. Applied Health Economics and Health Policy 2005; 4:191 196. Brouwers JRBJ, Duyvendak M, van Roon EN. Commentaar op NHG standaard Osteoporose. Pharmaceutisch Weekblad 2005; 47:1488 1490. Donker GA, Groenhof F, van der Veen WJ. Toenemend aantal voorschriften voor methylfenidaat in huisartspraktijken in Noordoost Nederland, 1998 2003. Nederlands Tijdschrift voor Geneeskunde 2005; 149:1742 1747. Duyvendak M, Naunton M, Peterson GM, Brouwers JRBJ. A pilot study on doctors beliefs and knowledge on corticosteroid induced osteoporosis prevention: identifying barriers to improve practice. European Journal of Hospital Pharmacy Science 2005; 11:114 120. Eherensberger U, Vasel Biergans A, Dhillon S, Heide L, Taxis K. Evaluation of a British German postgraduate course in clinical pharmacy. Pharmacy Education 2005; 5:7 11. Fokkema MR, Musket FA, van Doormaal JJ. Leefstijlinterventie ter preventie van hart en vaatziekten. Nederlands Tijdschrift voor Geneeskunde 2005; 149:2607 2612. Fokkema MR, Meijer WM, de Jong van den Berg LTW. Benefits and concerns regarding folic acid fortification. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde 2005; 30:218 223.

296 Graduate School for Health Research SHARE Self evaluation 2003-2008 Houweling ST, Kleefstra N, van Ballegooie E, Miedema K, Rischen R, Heeg JE. Diagnostiek van diabetes mellitus: beperkte plaats voor draagbare glucosemeters. Nederlands Tijdschrift voor Geneeskunde 2005; 149:694 697. Houwerzijl EJ, van Haelst PL, van Doormaal JJ, Gans RO. Klinisch denken en beslissen in de praktijk. Een 31 jarige vrouw met voorbijgaande visusklachten en polycytemie. Nederlands Tijdschrift voor Geneeskunde 2005; 159:125 131. Kasje WN, Denig P, de Graeff PA, Haaijer Ruskamp FM. Perceived barriers for treatment of chronic heart failure in general practice; are they affecting performance? BMC Family Practice 2005; 6:19?. Klok RM, Brouwer WBF, Annemans LJP, Bos JM, Postma MJ. Towards a healthier discount procedure. Expert Review of Pharmacoeconomics & Outcomes Research 2005; 5:59 63. Lems WF, Bijlsma JWJ, Brouwers JRBJ. Maagdarmklachten door bisfosfonaten. Pharmaceutisch Weekblad 2005; 47:1491 1492. Meijer WM, de Smit DJ, Jurgens RA, de Jong van den Berg LTW. Improved periconceptional use of folic acid after patient education in pharmacies: promising results of a pilot study in the Netherlands. International Journal of Pharmacy Practice 2005; 13:47 51. Niessen WJ, Stewart RE, Broer J, Haaijer Ruskamp FM. Vermindering van gebruik van benzodiazepinen door een brief van de eigen huisarts aan chronische gebruikers. Nederlands Tijdschrift voor Geneeskunde 2005; 149:356 361. Otten MH, Frankenhuisen R, Brouwers JRBJ. Welke antacida hebben de voorkeur in de zwangerschap? Nederlands Tijdschrift voor Obstetrie en Gynaecologie 2005; 118:176 177. Schuling J, Heineman MJ. Seksuele intimidatie van co assistenten tijdens hun stage (comment, letter). Nederlands Tijdschrift voor Geneeskunde 2005; 149:1425 1426. Stewart RE, Broer J, van der Werf GT, Meyboom de Jong B. De werkbelasting van huisartsen in achterstandswijken in de stad Groningen. TSG: Tijdschrift voor Sociale Gezondheidszorg 2005; 83:75 82. Taxis K, Kloft C. Interaktionsproblematik in der Pharmakotherapie mit Immunsuppressiva. Pharmazie in unserer Zeit 2005; 34:332 343. Ubink Veltmaat LJ, Bilo HJ, Groenier KH, Rischen RO, Meyboom de Jong B. Challenges in preventing cardiovascular complications in type 2 diabetes in primary care. European Journal of General Practice 2005; 11:11 16. van Grootheest AC, de Jong van den Berg LTW. The role of hospital and community pharmacists in pharmacovigilance. Research in Social and Administrative Pharmacy 2005; 1:33. 2 0 0 6 Boersma C, Radeva J, Koopmanschap M, Voors A, Postma MJ. Economic evaluation of valsartan in patients with chronic heart failure: results from Val HeFT adapted to the Netherlands. Journal of Medical Economics 2006; 9:121 131. de Jong van den Berg LTW. Duidelijk verhoogd risico op congenitale afwijkingen door het gebruik van angiotensineconverterend enzym (ACE) remmers in de zwangerschap (letter). Nederlands Tijdschrift voor Geneeskunde 2006; 150:2222 2223 (2344: correctie). de Vreede IM, Burger H, van Vliet IM. Voorspelling van de effectiviteit van ECT bij een depressie met routinematig verzamelde data. Tijdschrift Psychiatrie 2006; 48:619 625. de Vries R, Boersma C, Postma MJ. Scheve verdeling ziekenhuisopnames compliceert kostenanalyse. Valkuilen bij beoordeling kostenreductie. Pharmaceutisch Weekblad 2006; 141:522 523. Faber A, de Jong van den Berg LTW. Boven 50 jaar niet doorgaan met orale anti conceptie. Pharmaceutisch Weekblad 2006; 141:1295. Olczak A, Grzesiowski P, Hryniewicz W, Haaijer Ruskamp FM. [Self medication with antibiotics in Poland]. Polski Merkuriusz Lekarski 2006; 20:151 154. Postma MJ, Baltussen RMPM, Palache MA, Wilschut J. Further evidence for favorable cost effectiveness of elderly influenza vaccination. Expert Review of Pharmacoeconomics Outcomes Research 2006; 6:215 227.

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 297 Prins E, van der Wal M, Groot Jebbink G, Burgerhof H, Jaarsma T. Therapietrouw bij patiënten met chronisch hartfalen: validering van een vragenlijst. Verpleegkunde 2006; 21:108 115. Spijker Huiges A, Winters JC, Meyboom de Jong B. Patients views on dyspepsia and acid suppressant drug therapy in general practice. European Journal of General Practice 2006; 12:10 14. Tolley K, Postma MJ. Pharmacoeconomics and market access in Europe: case studies in Scotland and the Netherlands. ISPOR Connections 2006; 12:3 6. van Bruggen JAR, Gorter KJ, Stolk RP, Rutten GEHM. Delen en delegeren, panacee voor betere diabeteszorg? Huisarts en Wetenschap 2006; 49:598 605. van der Veen WJ, van der Werf GT. Gebruik van rofecoxib in de Noord Nederlandse huisartspraktijk, 2000 2004: achtergronden en gevolgen. Nederlands Tijdschrift voor Geneeskunde 2006; 150:1016 1021. van Ham I, Verhoeven AA, Groenier KH, Groothoff JW, de Haan J. Job satisfaction among general practitioners: A systematic literature review. European Journal of General Practice 2006; 12:174 180. 2 0 07 Blaauwbroek R, Groenier KH, Kamps WA, Meyboom de Jong B, Postma A. Late effects in adult survivors of childhood cancer: the need for life long follow up. Annals of Oncology 2007; 18:1898 1902. de Jong WK, Fidler V, Groen HJM. Prognostic classification with laboratory parameters or imaging techniques in small cell lung cancer. Clinical Lung Cancer 2007; 8:376 381. de Nijs RN, Jacobs JW, Lems WF, Laan RF, Algra A, Huisman AM, Buskens E, de Laet CE, Oostveen JC, Geusens PP, Bruyn GA, Dijkmans BA, Bijlsmat JW. Alendroninezuur effectiever dan alfacalcidol voor preventie van osteoporose bij patiënten met een reumatische ziekte die starten met glucocorticoïdtherapie. Nederlands Tijdschrift voor Geneeskunde 2007; 151:1178 1185. Dobre D, van Veldhuisen DJ, DeJongste MJL, Haaijer Ruskamp FM. Prescription of beta blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival (letter). European Journal of Heart Failure 2007; 9:962 963. Goorhuis Brouwer SM, Luinge MR, Post WJ. Spreeknormen voor jonge kinderen: van GMS naar SNEL. Tijdschrift voor Jeugdgezondheidszorg 2007; 39:9 14. Greving JP, Denig P, de Zeeuw D, Bilo HJ, Haaijer Ruskamp FM. Trends in hyperlipidemia and hypertension management in type 2 diabetes patients from 1998 2004: a longitudinal observational study. Cardiovascular Diabetology 2007; 6:25. Ivanovic N, Beinema MJ, Brouwers JRBJ, Naunton M, Postma MJ. Thromboprophylaxis in total hip replacement surgery in Europe: acenocoumarol, fondaparinux, dabigatran and rivaroxban. Expert Reviews Pharmacoeconomics Outcomes research 2007; 7:49 58. Kleefstra N, Houweling ST, Meyboom de Jong B, Bilo HJG. Weinig nut van bloeddrukmeting aan beide armen; longitudinale studie naar interarmbloeddrukverschillen en de reproduceerbaarheid daarvan bij patiënten met diabetes mellitus type 2. Nederlands Tijdschrift voor Geneeskunde 2007; 151:1509 1514. Klok RM, Al Hadithy AFY, van Schayk NPJT, Antonisse AJJ, Caro JJ, Brouwers JRBJ, Postma MJ. Pharmacoeconomics of quetiapine for the management of acute mania in bipolar I disorder. Expert Reviews Pharmacoeconomics Outcomes research 2007; 7:459 467. Logtenberg SJ, Kleefstra N, Denig P, Houweling ST, Ubink Veltmaat LJ. Consequenties van de nieuwe NHG standaard type 2 diabetes mellitus voor de medicamenteuze bloeddruk, (micro)albuminurie en vetspectrumbehandeling (Zodiac 8). Nederlands Tijdschrift voor Diabetologie 2007; 5:51 57. Luinge MR, Post WJ, Goorhuis Brouwer SM. Het identificeren van mijlpalen in de taalontwikkeling van kinderen van 1 tot 6 jaar. Stem, Spraak en Taalpathologie 2007; 15:33 52. Luinge MR, Post WJ, Goorhuis Brouwer SM. The language screening instrument SNEL. Educational & Child Psychology 2007; 24:18 28. Oud MJ, Schuling J, Slooff CJ, Meyboom de Jong B. How do general practitioners experience providing care for their psychotic patients? BMC Family Practice 2007; 8:37.

298 Graduate School for Health Research SHARE Self evaluation 2003-2008 Plas M, Fleuren M, Friele R, Haaijer Ruskamp F, Keijsers J, Ravensbergen J, Klazinga N, Wensing M. Begrippenkader voor het wat en het waarom bij implementatie van vernieuwingen in patiëntenzorg en preventie. TSG : tijdschrift voor gezondheidswetenschappen 2007; 85:160 165. 2 0 0 8 Besselink MGH, Santvoort HC, Buskens E, Boermeester MA, Goor Hv, Timmerman HM, Nieuwenhuijs VB, Bollen TL, Ramshorst Bv. Probioticaprofylaxe bij voorspeld ernstige acute pancreatitis : een gerandomiseerde, dubbelblinde, placebogecontroleerde trial. Nederlands Tijdschrift voor Geneeskunde 2008; 152:685 696. Bocca G, Stolk RP, Scheenstra R, Sauer PJ. Non alcoholic fatty liver disease bij kinderen: een nieuwe complicatie van obesitas. Nederlands Tijdschrift voor Geneeskunde 2008; 152:2443 2447. de Bock GH, Beusmans GHMI, Hinloopen RJ, Corsten MC, Salden NMA, Scheele ME, Wiersma TJ. NHG Standaard Diagnostiek van mammacarcinoom. Tweede herziening. Huisarts en Wetenschap 2008; 51:598 609. de Lange E, van der Veen WJ, van der Werf GTh. Huisartsgeneeskundige zorg in het verzorgingshuis.een vergelijkende studie naar de zorg van de huisarts voor bewoners van verzorgingshuizen en ouderen die zelfstandig wonen. Tijdschrift voor Gerontologie en Geriatrie 2008; 39:107 114. Doekhie FS, Morreau H, de Bock GH, Speetjens FM, Dekker Ensink NG, Putter H, vand e Velde CJH, Tollenaar RAEM, Kuppen PJK, Sialyl lewis X. Expression and lymphatic microvessel density in primary tumors of node neagtive colorectal cancer patients predict disease recurrence. Cancer Microenvironment 2008; 1:141 151. Gallivan S, Pagel C, Utley M, Franklin B, Taxis K, Barber N. A technical note concerning non adherence to drug therapy : exact expressions for the mean and variance of drug concentration. Health Care Management Science 2008; 11:296 301. Janssen PG, Gorter KJ, Stolk RP, Akarsubasi M, Rutten GE. Three years follow up of screen detected diabetic and non diabetic subjects: who is better off? The ADDITION Netherlands study. BMC Family Practice 2008; 9:art nr 67. Klappe Sabadi G, Jansman FGA, Honkoop HA, Otter R, WSillemse PHB, Brouwers JRBJ. Regionale verschillen in voorschrijfgedrag trastuzumabopnieuw getoetst. Pharmaceutisch Weekblad Wetenschappelijk Platform 2008; 2:154 158. Nijman H, Reesink Peters N, Postma M, Daemen T, Wilschut J, Zee Avd. Profylactische vaccins ter voorkoming van HPV gerelateerde kanker. Tijdschrift Kanker 2008; 32:6 10. Oosterheert JJ, Bonten MJM, Schneider MME, Buskens E, Lammers JWJ, Hustinx WNM, Kramer MHH, Prins JM, Slee PT. Vroege omschakeling van intraveneuze naar orale antibiotica even effectief als standaard intraveneuze therapie bij ernstige, buiten het ziekenhuis opgelopen pneumonie. Nederlands Tijdschrift voor Geneeskunde 2008; 152:269 274. Reinders MK, van Roon EN, Jansen TLTA, Delsing J, van de Laar MAFJ, Brouwers JRBJ. Effectiviteit en verdraagbaarheid van urinezuurverlagende behandeling. Gerandomiseerd gecontroleerd onderzoek van benzbromaron versus probenecide bij jicht na falen allopurinol. Pharmaceutisch Weekblad Wetenschappelijk Platform 2008; 2:19 23. Smink BE, Lusthof KJ, de Gier JJ, Uges DR, Egberts AC. The relation between the blood benzodiazepine concentration and performance in suspected impaired drivers. Journal of Forensic and Legal Medicine 2008; 15:483 488. Smink BE, Movig KL, Lusthof KJ, de Gier JJ, Uges DR, Egberts AC. The relation between the use of psychoactive substances and the severity of the injury in a group of crash involved drivers admitted to a regional trauma center. Traffic Injury Prevention 2008; 9:105 108. van den Dungen C, Hoeymans N, Gijsen R, van den Akker M, Boesten J, Brouwer H, Smeets H, van der Veen WJ, Verheij R, de Waal M, Schellevis F, Westert G. What factors explain the differences in morbidity estimations among general practice registration networks in the Netherlands? A first analysis. European Journal of General Practice 2008; 14 Suppl 1:53 62. van Hunsel FPAM, de Smet PAGM, van Klei N, van Grootheest AC. Indonesische kruidenthee bevat ongewenste Westerse geneesmiddelen. Pharmaceutisch Weekblad Wetenschappelijk Platform 2008; 2:167 168.

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 299 van Vliet Ostaptchouk JV, Onland Moret NC, Shiri Sverdlov R, van Gorp PJ, Custers A, Peeters PH, Wijmenga C, Hofker MH, van der Schouw YT. Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle aged women. PLoS ONE 2008; 3:e1405. Zonderland HM, Tuut MK, den Heeten GJ, Asperen CJ, de Bock GH, Rutqers EJ, Westenend PJ, Smit GM, Benraadt J. Richtlijn screening en diagnostiek van het mammacarcinoom (herziening). Nederlands Tijdschrift voor Geneeskunde 2008; 152:2336 2339. B o o k c h a p t e r s 2 0 0 4 van der Veen WJ, Meyboom de Jong B. Age and gender. In: Jones R, Britten N, Culpepper L et al (eds). Oxford textbook of primary medical care. Oxford, Oxford University Press, 2004: pp. 153 160. 2 0 0 5 Burger H, Hofman A. Klinische epidemiologie. In: van der Meer J, Stehouwer C (eds). Interne geneeskunde. Houten, Bohn Stafleu van Loghum, 2005: pp. 1 15. Buurma H, de Gier JJ, Egberts ACG. De apotheek als zorgpraktijk. In: Buurma H, de Jong van den Berg LTW, Leufkens HGM (eds). Het geneesmiddel, 4e geh herz dr. Maarssen, Elsevier Gezondheidszorg, 2005. de Haan J, Schuling J. Organisatie van het onderwijs in de opleidingspraktijk. In: de Haan J, Dijkers FW, Nijland A (eds). Praktijkvoering voor de huisarts. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 171 178. de Haan J, Baarveld F. Het kwaliteitsjaarverslag. In: de Haan J, Dijkers FW, Nijland A (eds). Praktijkvoering voor de huisarts. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 215 219. de Haan J, Baarveld F. Instroommanagement in de huisartspraktijk. In: de Haan J, Dijkers FW, Nijland A (eds). Praktijkvoering voor de huisarts; management van de huisartspraktijk. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 51 55. de Jong van den Berg LTW, de Smit DJH. Communicatie. In: Buurma H, de Jong van den Berg LTW, Leufkens HGM (eds). Het geneesmiddel, 4e geh herz dr. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 188 211. de Vries CS, de Jong van den Berg LTW. Spontane rapportage en farmaco epidemiologie. In: Buurma H, de Jong van den Berg LTW, Leufkens HGM (eds). Het geneesmiddel, 4e geh herz dr. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 212 231. Haaijer Ruskamp FM, Denig P. Voorschrijven van geneesmiddelen. In: Buurma H, de Jong van den Berg LTW, Leufkens HGM (eds). Het geneesmiddel, 4e, geh. herz. dr. Maarssen, Elsevier Gezondheidszorg, 2005: pp. 126 143. Schaafsma ES. Counselling, concordance, and communication: innovative education for pharmacists. In: Wuliji T, Airaksinen M (eds). Counselling, concordance, and communication: innovative education for pharmacists. The Hague, IPSF/FIP, 2005: pp. 17 20. 2 0 0 6 Brouwers JRBJ. Geneesmiddelen bij aandoeningen van het spijsverteringskanaal. In: van Everdingen JJE (ed). Het Medisch Handboek. Utrecht/Antwerpen, Kosmos Uitgevers, 2006: pp. 922 926. Brouwers JRBJ. Spijsverteringsstelsel. In: van Everdingen JJE (ed). Het Medisch Handboek. Utrecht/ Antwerpen, Kosmos Uitgevers, 2006: pp. 620 669. Mulder CJJ, Brouwers JRBJ. Gastroenterologie. In: van Everdingen JJE, Glerum JH (eds). Diagnose en therapie: jaarboek 2007. Houten, Bohn Stafleu van Loghum, 2006: pp. 191 227. 2 0 07 Brouwers JRBJ, Taxis K. Pharmakodynamische Interaktionen. In: Högger P, Strehl E (eds). Repetitorium Klinische Pharmazie. Arbeitsbuch für Prüfung und Praxis. Eschborn, Govi Verlag Pharmazeutischer Verlag GmbH, 2007: pp. 117 119. Brouwers JRBJ, Taxis K. Beurteilung der klinische Relevanz von unerwünschten Arzneimittelwirkungen. In: Högger P, Strehl E (eds). Repetitorium Klinische Pharmazie. Arbeitsbuch für Prüfung und Praxis. Eschborn, Govi Verlag Pharmazeutischer Verlag GmbH, 2007: pp. 101 112.

300 Graduate School for Health Research SHARE Self evaluation 2003-2008 de Bock GH, de Vries J. Follow up. In: Wobbes T, Nortier JWR, Koning CCE (eds). Handboek mammacarcinoom. Utrecht, De Tijdstroom, 2007: pp. 311 320. Festen HPM, de Wit NJ, Brouwers JRBJ. Gastroenterologie. In: van Everdingen JJE, Glerum JH (eds). Diagnose en Therapie 2008. Houten, Bohn Stafleu van Loghum, 2007: pp. 130 154. Knuistingh Neven A, de Bock GH. Mastopathy / painful breasts. In: Eekhof JAH, Knuistingh Neven A, Verheij TJM, Hopcroft K (eds). Minor ailments in primary care an evidence based approach, rev ed. Maarssen, Elsevier, 2007: pp. 309. Moons KG, Burger H. Designs voor observationeel onderzoek. In: Plochg T, Juttmann RE, Klazinga NS, Mackenbach JP (eds). Handboek gezondheidszorgonderzoek. Houten, Bohn Stafleu van Loghum, 2007: pp. 94 110. Taxis K. Bei älteren Patienten problematische Arzneistoffe (Anhang). In: Högger P, Strehl E (eds). Repetitorium Klinische Pharmazie. Eschborn, Govi Verlag, 2007: pp. 489 492. Taxis K, Brouwers JRBJ. Besondere Therapiesituationen Arzneimitteltherapie bei Senioren. In: Högger P, Strehl E (eds). Repetitorium Klinische Pharmazie. Eschborn, Govi Verlag, 2007: pp. 207 212. 2 0 0 8 Brouwers JRBJ, van der Hooft C. De patiënt met beperkte therapietrouw. In: Olde Rikkert MGM, Flamaing J, Petrovic M, Schols JMGA, Hoefnagels WHL (eds). Utrecht, Tijdstroom, 2008: pp. 387 400. de Gier JJ. Contraindicatie verkeersdeelname. In: de Gier JJ (ed). Commentaren medicatiebewaking. Houten, Stichting Health Base, 2008: pp.? Haaijer Ruskamp FM, Andersen M, Vander Stichele R. Prescribing quality indicators. In: Hartzema AG, Tilson HH, Chan KA (eds). Pharmacoepidemiology & therapeutic risk management. Cincinnati, OH, Harvey Whitney Books, 2008: pp. 197 218. B o o k s 2 0 0 3 Dukes MNG, Haaijer Ruskamp FM, de Jonckheere CP, Rietveld AH, (eds). Drugs and money; prices, affordibility and cost containment. Amsterdam etc, IOS Press, 2003. 2 0 0 5 Buurma H, de Jong van den Berg LTW, Leufkens HGM, (red). Het geneesmiddel. Maarssen, Elsevier Gezondheidszorg, 2005. Dukes MNG, Haaijer Ruskamp FM, de Jonckheere CP, Rietveld AH, (eds). Drugs and money; prices, affordibility and cost containment. Amsterdam etc, IOS Press, 2003. P h D t h e s e s (c o) s u p e r v i s e d 2 0 0 3 Boendermaker PM. Meesterschap: van verkenning naar herkenning van de goede huisartsopleider. Supervisors: prof B Meyboom de Jong, prof RP Zwierstra, prof JCM Metz Co supervisor: dr J Schuling de Visser C. Health and health risks on Urk: a study about cardiovascular disease and type 2 diabetes. Supervisor: prof B Meyboom de Jong Co supervisors: dr HJG Bilo, dr ir EJM Feskens, dr ir GJ te Meerman Deneer VHM. Episodic treatment and prevention of paroxysmal atrial fibrilation: studies on flecainide and sotalol. PhD thesis Faculty of Mathematics and Physics, University of Groningen Supervisors: prof JRBJ Brouwers, prof JH Kingma Monster TBM. Assessing drug influences on urinary albumin excretion. PhD thesis Faculty of Mathematics and Physics, University of Groningen Supervisors: prof LTW de Jong van den Berg, prof PE de Jong SHARE thesis (All theses: University Medical Center Groningen, University of Groningen, unless otherwise stated)

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 301 Rijcken CAW. Pharmacy data as a tool for assessing antopsychotic drug use. PhD thesis Faculty of Mathematics and Physics, University of Groningen Supervisor: prof LTW de Jong van den Berg Schirm E. Drug exposure from conception till adulthood. PhD thesis Faculty of Mathematics and Physics, University of Groningen Supervisor: prof LTW de Jong van den Berg Co supervisor: dr H Tobi Terpstra WF. Beyond blood pressure monitoring. Supervisors: prof HJGM Crijns, prof PA de Graeff, prof B Meyboom de Jong Co supervisors: dr JF May, dr AJ Smit van Grootheest AC. Improving pharmacovigilance and the role of the pharmacist. PhD thesis Faculty of Mathematics and Physics, University of Groningen Supervisor: prof LTW de Jong van den Berg Co supervisor: dr EP van Puijenbroek 2 0 0 4 Baarveld F. Sportgerelateerde problemen in de huisartspraktijk. Supervisor: prof B Meyboom de Jong Co supervisors: dr J Schuling, dr GC van Enst Bos JM. Pharmacoeconomics in infectious disease; the evaluation of prevention programmes. PhD thesis Faculty of Mathematics and Sciences, University of Groningen Supervisor: prof LTW de Jong van den Berg Co supervisor: dr ThFJ Tromp Gerritsen MJJ. Cognitive aftermath of ischemic stroke. Supervisors: prof BG Deelman, prof B Meyboom de Jong Co supervisor: dr IJ Berg Groenier KH. Empirical classification of shoulder complaints. Supervisor: prof B Meyboom de Jong Co supervisors: dr WH van Schuur, dr JC Winters Hart HE. Health related quality of life in patients with diabetes mellitus type I. PhD thesis Erasmus University, Rotterdam Supervisors: prof M Berg, prof B Meyboom de Jong Co supervisor: dr HJG Bilo Kasje WN. Implementing joint treatment guidelines to improve prescribing in general practice. Supervisors: prof FM Haaijer Ruskamp, prof PA de Graeff Co supervisor: dr P Denig Stuurman Bieze AG. Interventions on the principle of Pulmonary Medication Profiles; a strategy in Pharmaceutical Care. PhD thesis Faculty of Mathematics and Sciences, University of Groningen Supervisor: prof LTW de Jong van den Berg Co supervisor: dr ThFJ Tromp Tramarin A. The changing economic burden of HIV/AIDS in Italy. PhD thesis Faculty of Mathematics and Sciences, University of Groningen Supervisor: prof JRBJ Brouwers Co supervisor: dr MJ Postma Ubink Veltmaat LJ. Type 2 diabetes mellitus in a dutch region. Epidemiology and shared care. Supervisor: prof B Meyboom de Jong Co supervisor: dr HJG Bilo Visser Keizer AC. The impact of emotional and cognitive changes after stroke; a longitudina, community based study. Supervisors: prof B Meyboom de Jong, prof BG Deelman Co supervisor: dr IJ Berg Wachters Kaufmann CSM. Voorlichting aan CVA patiënten en hun centrale verzorgers. Supervisors: prof B Meyboom de Jong, prof TH The; Co supervisor: dr J Schuling SHARE thesis (All theses: University Medical Center Groningen, University of Groningen, unless otherwise stated)

302 Graduate School for Health Research SHARE Self evaluation 2003-2008 2 0 0 5 Bergman GJD. Manipulative therapy for shoulder complaints in general practice. Supervisors: prof B Meyboom de Jong, prof K Postema Co supervisors: dr JC Winters, dr GJMG van der Heijden Houweling ST. Taakdelegatie in de eerste en tweedelijns diabeteszorg; resultaten van de DISCOURSE studies. Supervisor: prof B Meyboom de Jong Co supervisor: dr HJG Bilo Jansman FGA. Chemotherapy for patients with colorectal cancer: potential contributions of the clinical pharmacist. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof JRBJ Brouwers, prof DTh Sleijfer Mol PGM. The quest for optimal antimicrobial therapy. Supervisors: prof FM Haaijer Ruskamp, prof ROB Gans, prof JE Degener 2 0 0 6 Atthobari J. Drug use in population screening: Pharmacoepidemiological and pharmacoeconomical aspects. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof LTW de Jong van den Berg, prof PE de Jong, prof MJ Postma Cohen D. Diabetes mellitus in schizophrenia or schizoaffective disorder: a iatrogenic or endogenic problem? PhD thesis Utrecht University Supervisors: prof DE Grobbee, prof RP Stolk Dobre D. Treatment of heart failure and patient outcomes in real life. Supervisors: prof FM Haaijer Ruskamp, prof R Sanderman, prof DJ van Veldhuisen Co supervisors: dr AV Ranchor, dr MJL de Jongste Faber A. Stimulant treatment in children: a Dutch perspective. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof LTW de Jong van den Berg, prof R Minderaa Co supervisor: dr H Tobi Klok RM. Pharmacoeconomic analysis of proton pump inhibitor therapy and interventions to control Helicobacter pylori infection. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof MJ Postma, prof JRBJ Brouwers Meijer WM. Drug safety. Pregnancy; studying and communicating teratogenic risks. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof LTW de Jong van den Berg, prof JRBJ Brouwers Meiland R. Pathogenesis, diagnosis, and consequences of bacteriuria in women with or without diabetes mellitus. PhD thesis Utrecht University Supervisors: prof LM Hoepelman, prof RP Stolk 2 0 07 de Roos MAJ. Diagnostics and prognostics in ductal carcinoma in situ of the breast. Supervisor: prof T Wiggers Co supervisor: dr GH de Bock Foster JM. Development and validation of the Inhaled Corticosteroid Questionnaire a model for the measurement of patient perveived side effects by self report. Supervisors: prof T van der Molen, prof P Hannaford, prof R Sanderman Greving JP. Trends in cardiovascular drug prescribing in Dutch general practice: role of patient and physician related characteristics. Supervisors: prof FM Haaijer Ruskamp, prof D de Zeeuw Co supervisor: dr P Denig Grigoryan L. Self medication with antibiotics in Europe and its determinants. Supervisors: prof FM Haaijer Ruskamp, prof JE Degener SHARE thesis (All theses: University Medical Center Groningen, University of Groningen, unless otherwise stated)

Publications E v i d e n c e B a s e d M e d i c i n e i n P r a c t i c e 303 Niemeijer AS. Neuromotor tast training physiotherapy for children with developmental coordination disorder. PhD thesis Faculty of Behavioural and Social Sciences, University of Groningen Supervisors: prof TW Mulder, prof BCM Smits Engelsman Co supervisor: dr MM Schoemaker Sturm HB. Influencing physician prescribing in an international context: the role of systems, policies and patients. Supervisors: prof FM Haaijer Ruskamp, prof WH van Gilst Visser E. Accident Proneness as an expression of self destructiveness. PhD thesis University Medical Center Groningen, University of Groningen Supervisors: prof RP Stolk, prof J Neeleman Co supervisor: dr JGM Rosmalen 2 0 0 8 de Vries TW. Improving care in prediatric asthma: patients, prescriptions, pharmacovigilance, pathogens and particels. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof JRBJ Brouwers, prof LTW de Jong van den Berg, prof EJ Duiverman Laan W. Anti inflammatory drugs and psychosis. PhD thesis Utrecht University Supervisors: prof DE Grobbee, prof RS Kahn Co supervisor: dr H Burger Reinders MK. Practice research in the field of gout: clinical pharmacology of antihyperuricemic drugs. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof JRBJ Brouwers, prof MAFJ van de Laar Co supervisors: dr TLThA Jansen, dr EN van Roon Smink BE. Benzodiazepines and traffic safety. PhD thesis Faculty of Mathematics and Natural Sciences, University of Groningen Supervisors: prof DRA Uges, prof ACG Egberts, prof JJ de Gier Co supervisor: dr KJ Lusthof van Hulst M. Health economics of blood transfusion safety. PhD thesis University Medical Center Groningen, University of Groningen Supervisors: prof MJ Postma, prof CTh Smit Sibinga SHARE thesis (All theses: University Medical Center Groningen, University of Groningen, unless otherwise stated)