NEWS IN ONCO-HEMATOLOGY: LEARNING FROM CHILDREN

NEWS IN ONCO-HEMATOLOGY: LEARNING FROM CHILDREN Perugia, November 12-14, 2010 Presidents: Massimo F. Martelli, Fulvio Porta Comitato per la vita Daniele Chianelli

Requested auspices: Alto Patronato del Presidente della Repubblica Università degli Studi di Perugia Regione Umbria Comune di Perugia AIEOP Associazione Italiana Ematologia ed Oncologia Pediatrica GITMO Gruppo Italiano per il Trapianto di Midollo Osseo Cellule staminali emopoietiche e terapia cellulare SIE Società Italiana di Ematologia SIES Società Italiana di Ematologia Sperimentale Presidents: Massimo F. Martelli, Fulvio Porta Scientific Secretariat: Franco Aversa, Cristina Mecucci Hematology and Pediatric Oncology-Hematology University of Perugia, Perugia General Hospital Ph. +39 075 5784173 / +39 075 5783808 Fax +39 075 5784173 E-mail: aversa@unipg.it / crimecux@unipg.it Organizing Secretariat: Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Ph. +39 051 4210559 - Fax +39 051 4210174 E-mail: ercongressi@triumphgroup.it www.ercongressi.it FACULTY Giuliana Alimena Roma William Arcese Roma Maurizio Aricò Firenze Franco Aversa Perugia Andrea Bacigalupo Genova Giuseppe Basso Padova Andrea Biondi Monza Chiara Bonini Milano Jacqueline Boultwood Oxford - UK Giovanni Cazzaniga Monza Mario Cazzola Pavia Sabina Chiaretti Roma Fabio Ciceri Milano Lucio Crinò Perugia Kim De Keersmaecker Leuven - B Mauro Di Ianni L Aquila Carlo Dufour Genova Hermann Einsele Tubingen - D Brunangelo Falini Perugia Robin Foà Roma Wilhelm Friedrich Ulm - D Ephraim J. Fuchs Baltimore - USA Claudia Haferlach München - D Rupert Handgretinger Tübingen - D Christine Harrison New Castel - UK Eva Hëllstrom-Lindberg Stockholm - S Giorgio Inghirami Torino Roberta La Starza Perugia Elizabeth Macintyre Parigi - F Massimo Fabrizio Martelli Perugia Maria Paola Martelli Perugia Cristina Mecucci Perugia Vesna Najfeld New York - USA Katia Perruccio Perugia Andrea Pession Bologna Stefano A. Pileri Bologna Giovanni Pizzolo Verona Fulvio Porta Brescia Alessandro Rambaldi Bergamo Yair Reisner Rehovot - IL Joseph Ribera Badalona - ES Antonio Maria Risitano Napoli Irene Roberts London - UK Angelo Rosolen Padova Loredana Ruggeri Perugia Stephen E. Sallan Boston - USA Brigitte Schlegelberger Hannover - D Susanne Schnittger München - D Martin Schrappe Kiel - D Pietro Sodani Roma Giorgina Specchia Bari Paolo Sportoletti Perugia Harald Stein Berlin - D Peter Vandenberghe Leuven - B Andrea Velardi Perugia Paul Veys London - UK Neal S. Young Bethesda - USA 1 2

November 12, 2010 2.30 p.m. Opening Ceremony 3.00 p.m. - 7.00 p.m. ACUTE LYMPHOID LEUKEMIA: in children and adults A. Biondi Children J. Ribera Adults S.E. Sallan G. Basso, G. Pizzolo Pediatric-like protocols in adults R. Foà Age and biology I. Roberts The fetal pathogenesis of leukaemias in children with Down syndrome 4.00 p.m. - 5.00 p.m. Open Coffee E. McIntyre, M. Schrappe G. Cazzaniga Role of MRD monitoring in children A. Rambaldi Role of MRD monitoring in adults R. La Starza New genetics and diagnosis of T-ALL S. Chiaretti Myeloid/T-ALL in children and adults C. Harrison New genetics and diagnosis of B-ALL K. De Keersmaecker Molecular pathogenesis and mouse models in T-ALL Panel Discussion: A. Biondi G. Basso R. Foà E. McIntyre G. Pizzolo M. Schrappe 7.00 p.m. Welcome Cocktail November 13, 2010 9.00 a.m. - 1.00 p.m. NON-HODGKIN S LYMPHOMA AND AML: from ALK+ lymphomas to NPM1 mutations in leukemia M. Aricò, S.A. Pileri H. Stein A new subtype of childhood large B-cell lymphoma B. Falini AML with mutated nucleophosmin a) ALK protein in lymphomas L. Crinò, H. Stein G. Inghirami Molecular pathogenesis and mouse models of ALCL A. Rosolen Any perspective for targeted therapy with ALK kinase inhibitors? S.A. Pileri 11.00 a.m - 11.20 a.m. Coffee Break b) NPM1-mutated AML ALK-negative ALCL. Is it an entity? B. Falini, C. Mecucci P. Sportoletti How does the NPM1 mutant induce leukemia? C. Haferlach Which significance for chromosomal aberration in NPM1-mutated AML M.P. Martelli About the nature of leukemia initiating cells (LICs) in NPM1- mutated AML S. Schnittger Is monitoring of MRD important in NPM1-mutated AML? Panel Discussion: L. Crinò B. Falini C. Mecucci S. Pileri H. Stein 1.00 p.m. - 2.00 p.m. Lunch 3 4

November 13, 2010 2.00 p.m. - 6.00 p.m. BONE MARROW FAILURES: from congenital to acquired November 14, 2010 8.30 a.m. - 10.30 a.m. HLA-MISMATCHED HEMATOPOIETIC STEM CELL TRANSPLANTATION: from SCID to leukemia A. Bacigalupo, V. Najfeld Chairperson: F. Porta N.S. Young Molecular defects in constitutional and acquired BMF A.M. Risitano Immunosuppressive therapy 2010 C. Dufour Bone Marrow Transplantation for Fanconi anemia A. Bacigalupo The complete treatment algorithm 3.20 p.m. - 3.40 p.m. Coffee Break Y. Reisner SCID M.F. Martelli Leukemia a) Clinical experiences W. Friedrich, M.F. Martelli Non Hematological disorders G. Alimena, G. Specchia F. Porta HSCT for correction of primary immunodeficiencies P. Vandenberghe Severe Congenital Neutropenia, a genetically heterogeneous disease group at risk for leukemic transformation M. Cazzola Sideroblastic anemia B. Schlegelberger Role of monosomy 7 in congenital and acquired disorders J. Boultwood Recent advances in the molecular pathogenesis of the 5q-syndrome and other MDS with the del(5q) E. Hellström-Lindberg New MDS drugs: When - Why - How P. Veys RIC for Primary Immunodeficiency Disorders P. Sodani HLA-mismatched HSCT in Thalassemia patients A. Pession HLA-mismatched HSCT for Pediatric Solid Tumors Hematological disorders F. Aversa Positive selection R. Handgretinger Negative selection Panel Discussion: A. Bacigalupo M. Cazzola N. Young V. Najfeld F. Ciceri Rapamycin-based T-cell repleted haplo-sct for advanced leukemia W. Arcese Unmanipulated G-CSF-primed BMT E.J. Fuchs HLA-haploidentical stem cell transplantation with high-dose, post-transplantation cyclophosphamide 8.00 p.m. Social Dinner 10.30 a.m. - 11.30 a.m. Open Coffee 5 6

November 14, 2010 10.30 a.m. - 1.30 p.m. HLA-MISMATCHED HEMATOPOIETIC STEM CELL TRANSPLANTATION: from SCID to leukemia b) Strategies to enhance post-transplant immunity H. Einsele, A. Velardi A. Velardi Safe transfer of innate and adaptive immunity across HLA barriers L. Ruggeri The discovery of an NK-induced factor that rebuilds adaptive immunity after haploidentical hematopoietic transplantation K. Perruccio Thymosin alfa 1 administration boosts immune reconstitution and improves survival after matched sibling hematopoietic transplantation C. Bonini Immune reconstitution and immune correlates of clinical outcome in acute leukemia patients treated with haploidentical stem cell transplantation and donor lymphocytes H. Einsele Adoptive T-cell therapy against viral pathogens M. Di Ianni Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation Panel Discussion: H. Einsele W. Friedrich M.F. Martelli F. Porta Y. Reisner A. Velardi GENERAL INFORMATION MEETING VENUE Aula 7 Nuova Facoltà di Medicina e Chirurgia Università di Perugia Piazza Menghini, 1 06132 Perugia, Italy HOW TO GET THERE By car: From Firenze: Take the A1 motorway towards Perugia and take the exit Valdichiana. Go on to E45 road until the exit Madonna Alta and following the road signs to Ospedale, the Aula Magna is in front of it. From Roma: Take the A1 highway Roma-Firenze, exit Orte. Go on to E45 road, follow directions to wards Perugia, leave at Madonna Alta and follow the road signs to Ospedale, the Aula Magna is in front of it. By Train: Arrive to railway station Perugia San Sisto, the meeting venue can be reached from the train station in 10 minutes by foot. By Plane: A bus service links S. Egidio airport with Perugia city and the railway station. The meeting venue can be reached in 30 minutes by taxi. OFFICIAL LANGUAGE English REGISTRATION FEE Euro 300,00 (Italian VAT included) The registration fee includes: - Conference Kit - Coffee breaks - Participation in the Scientific Sessions - Lunches - Attendance Certificate - Welcome Cocktail - Social dinner REGISTRATION Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges and made out to Studio E.R. Congressi S.r.l. Please pay by: * Bank transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna Swift code: CECRIT 2C - Iban code: IT49L 06120 02400 CC0290002596 * Credit Card Please send a copy of the bank transfer with the registration form. In case of written cancellation before October 15, 2010, 80% of the registration fee will be refunded. 7 8

SCIENTIFIC INFORMATION REGISTRATION FORM NEWS IN ONCO-HEMATOLOGY: LEARNING FROM CHILDREN Perugia, November 12-14, 2010 SLIDES Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. BADGE All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. LAST NAME FIRST NAME Please, return this form by October 15, 2010 to: Studio E.R. Congressi - Triumph Group Via Marconi 36-40122 Bologna, Italy Phone +39 051 4210559 - Fax +39 051 4210174 ercongressi@triumphgroup.it Vat Number/ Tax Payer s Number: 06301101009 ATTENDANCE CERTIFICATE A certificate will be given to all participants at the end of the Meeting. ISTITUTION /DEPARTMENT CME Application for Italian CME credits has been made for physicians and biologists. CHANGES Parts of the program may be changed if necessary without notice. PROFESSION DISCIPLINE ADDRESS STATE/PROVINCE ZIP CITY COUNTRY TELEPHONE FAX MOBILE PHONE E-MAIL TAX PAYER S NUMBER (COD. FISCALE) FOR THE INVOICE: LAST NAME FIRST NAME PRIVATE ADDRESS STATE/PROVINCE ZIP CITY COUNTRY VAT NUMBER (P. IVA) TAX PAYER S NUMBER (COD. FISCALE) 9 10

REGISTRATION FORM HOTEL RESERVATION FORM NEWS IN ONCO-HEMATOLOGY: LEARNING FROM CHILDREN Perugia, November 12-14, 2010 REGISTRATION FEE (Italian VAT included): Euro 300,00 PAYMENT Bank Transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna. Swift code: CECRIT 2C - Iban code: IT49L 06120 02400 CC0290002596 CreditCard: Number Cvv (security number) Expiry date Owner VISA MASTERCARD AMERICAN EXPRESS I enclose a copy of the bank transfer with the registration form. Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizing Secretariat Studio E.R. Congressi. In case of written cancellation before October 15, 2010, 80% of the registration fee will be refunded. LAST NAME FIRST NAME INSTITUTE ADDRESS Please, fill in capital letters and return this form by October 15, 2010 to: C.S.C. S.r.l. - Via L.S. Gualtieri 11-06124 Perugia, Italy Phone +39 075 5730617 - Fax +39 075 5730619 info@csccongressi.it ZIP CITY STATE/PROVINCE TELEPHONE MOBILE PHONE FOR THE INVOICE: NAME TAX RESIDENCE FAX E-MAIL ZIP CITY STATE/PROVINCE VAT NUMBER (P. IVA) Information on Legislative Decree N. 196/2003 ( Personal data processing ) Signing this form and well informed on the Legislative Decree n.196/2003 concerning Personal data processing, I authorize Studio E.R. Congressi Srl, until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I gave my assent provided that Studio E.R. Congressi Srl complies with the regulations in force. I do not want that my personal data are divulged to third parties. TAX PAYER S NUMBER (COD. FISCALE) Invoice sending address (if different from the tax residence) ADDRESS ZIP CITY STATE/PROVINCE DATE SIGNATURE E-MAIL COMPULSORY 11 12

HOTEL RESERVATION FORM AKNOWLEDGMENTS HOTEL BOOKING I wish to book: Double Single Use Double Hotel 4 stars: 110,00 / 130,00 Hotel 3 stars: 80,00 / 100,00 Double Room - Single Use Double Room Comitato per la vita Daniele Chianelli This prices are per night, per room and include breakfast. Date of arrival 11/ 2010 Date of departure 11/ 2010 **The deposit per room is 125,00 of which 100,00 as deposit and 25,00 as agency fee. TOTAL HOTEL BOOKING Total number of rooms booked at 125,00 deposit each room. Total payment: Your credit card will be charged only for 25.00 (no refundable) when you make the reservation, and you will pay your hotel bill entirely and directly at the time of check-out. As a guarantee of your reservation, attach authorisation for the C.S.C. to charge your credit card for 125.00 in the event of cancellation of the reservation by and no later than 30 October 2010 and in the case of no-show. The Organizing Agency will assign rooms on a first come/first served basis. The Organizing Agency will send vouchers of the confirmed reservation, notifying participants of the name and address of the assigned hotel. In order to ensure comfortable accommodations that meet your personal needs, we advise conference participants to send their hotel reservation form as soon as possible. PAYMENT Credit Card: Visa Mastercard Cvv (security number) N. Exp. Date *Triple-digit security code printed on the back of Credit Card I hereby authorise the C.S.C. to charge to my credit card, Date Signature C.S.C. S.r.l. will address the invoice to firm or company only in the presence of their written claim which should be attached to the application form, (indicating also all fiscal data), along with copy of paid bank transfer. Genzyme Hospira Pfizer Adienne Pharma & Biotech Amgen Dompè Celgene Fresenius Biotech - Interlabo Roche Medac Merck Sharp & Dohme Novartis Oncology Pierre Fabre Pharma Schering Plough Date Signature PRIVACY LAW: permission is granted to manage, comunicate, including by computer, all the data in this form only for the purposes of the Congress (under the art. 13 and 23 of the Decree Law 196/2003) Date Signature CANCELLATION POLICY. For cancellation 100% penalty of the total amount will be applied. 13

PROGETTO WWW.STRUCHEL.COM Scientific Secretariat: Franco Aversa, Cristina Mecucci Hematology and Pediatric Oncology-Hematology University of Perugia, Perugia General Hospital Ph. +39 075 5784173 / +39 075 5783808 Fax +39 075 5784173 E-mail: aversa@unipg.it / crimecux@unipg.it Organizing Secretariat: Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Ph. +39 051 4210559 - Fax +39 051 4210174 E-mail: ercongressi@triumphgroup.it www.ercongressi.it