HumaStar 100 HumaStar 200

HumaStar 100 HumaStar 200 Marketing material Key advantages Competition Product features Rev. 4 22.05.2014

How to use this presentation?

How to use this presentation? This presentation has not only been prepared to provide you with information about the new HumaStar 100 and 200 automated analyzer! You may modify, translate or delete any part of this presentation. Use it to convince your customers of the advantages of YOUR new products. Make sure to carefully read every slide and delete any unwanted part before using it for presentation at your customers. Page 3

Scope of supply The slides provided in this section are concerned with availability, scope of supply and registration of the products.

Scope of delivery Included: Not included: Instrument UPS Computer & Monitor (necessary for operation) Printer Accessory Kit Wash Solutions (necessary for operation) Wash Add Special Wash Solution (NaOH) Cuvette Clean (turbidimetry) Page 5

Scope of delivery Mandatory Starter Spare Part Kit (5 instruments) Yearly Maintenance Kit Optional sample tray REF 16890/11: Primary Tubes 12-16 x 100mm Page 6

Marketing material The slides provided in this section show the most important documents, flyers, etc. which you can use for marketing and for product registration.

Human Website News 04.04.2013 General product information Page 8

Human Website Login - Download Youtube video Software and Settings Page 9

Documents Mailing 05.04.2013 Page 10

Documents Catalogue Page 11

Documents Regular Flyer Page 12

Documents Specifications & More Flyer Page 13

Documents User Manual (194 pages) and Service Manual Page 14

Documents Design Output (14 pages) Page 15

Documents Design Verification Report (23 pages) Page 16

Key advantages The slides provided in this section show the most important advantages of the HumaStar 100 and HumaStar 200 analyzers. These key advantages will be your selling arguments.

Page 18 Key advantages at a glance

Reliable results and flexibility Reagents and instruments from one supplier Reliable results HUMAN methods pre-installed and validated Reagent cooling Reliable results, less application work, less supports, less cost Flexibility (Open analyzer) Substrates, enzymes, turbidimetry, electrolytes Flexible to use other reagents Page 19

Reliable methods More testing than for any other open instrument Validation on 4 analyzers running for almost 1 year More than 140.000 tests Recovery (8 different controls) Precision (intra-assay and inter-assay 5 days, 3 levels for each) Limit of linearity Limit of detection Calibration stability Onboard stability Method comparison (internal and/or external AU400) Page 20

Pre-installed methods The laboratory has reliable results without doing any application work by themselves. Alk. Phosphatase AMP Alk. Phosphatase DEA Acid Phosphatase Albumin Alpha-Amylase Auto-Creatinine Auto-Bilirubin-T Auto -Bilirubin-D Complement C3 Complement C4 Calcium Cholesterol liquicolor CK-NAC CK-MB Gamma-GT Glucose liquicolor Glucose liquiuv GOT GPT HbA1c HDL Iron CAB* Iron TPTZ LDL LDH Lipase Magnesium Pancreas-Amylase Phosphor Potassium liquiuv Sodium liquicolor Total Protein Triglycerides Urea UV Uric Acid Uric Acid plus CRP IgA IgG IgM Last updated: 07.07.2014 * HumaStar 100 only Page 21

Secure your investment and be flexible The choice is up to the distributor Partially-closed instrument Allow or prohibit the laboratory the changing and creation of methods Hardware test counter Laboratory can only use reagent provided by the distributor ( partially-closed ) Distributor has more flexibility with instrument margins and can generate sustainable income from reagent sale Page 22

Partially-closed instrument Test counter Page 23

Intuitive user software Optimized for touch screen Page 24

Reliable results and easy creation of new methods Complete reaction curve for EVERY test Page 25

Reliable results Statistics for every sample - not only QC Page 26

Sample positions Long walk-away time High number of sample positions assures long walk-away time 80 60 40 20 0 50 100 150 200 250 300 Throughput max. [t/h] Page 27

Efficient workflow Ready for automation of modern laboratories 1 2 3 4 Full random-access, free choice of execution order Bi-directional LIS LIS standardized according ASTM Continuous loading and STAT LIS with standard Ethernet cable Primary tubes Internal barcode reader included Page 28

Maximum flexibility Wide choice of sample and reagent vials Reagents 20 ml bottles 1 ml cups 50 ml bottles 5 ml tubes 7 ml tubes 3 ml tubes 1 ml cups Samples Up to 16x100mm, 10 ml 3.5 ml cups Primary tubes 5 ml tubes Page 29

Page 30 Unique and recognizable design

Throughput High typical throughput HumaStar 100 has a constant throughput for 1- and 2-shot methods Maximum - Single Shot Double Shot Methods Typical Mix 200 t/h 100 t/h 64 t/h 100 t/h 95 t/h 127 t/h 0 t/h Mindray BS-120 HumaStar 100 Biosystems A15 HumaStar 200 Page 31

Economic and efficient operation Cuvette Wash Station 30.000 tests with 80 cuvettes Low consumable cost Low water consumption Very low carry-over 8-step wash cycle 2 nd cleaning solution Extra washing definable in method Automatic monitoring of cuvettes 2nd cleaning solution Page 32

Reduce expenses New clinical chemistry family (low to medium throughput) HumaStar 100 (March 2013) HumaStar 200 (Mai 2013) HumaStar 300SR (2015) Identical user software Identical hardware components Page 33

Reduce expenses Identical user software Reduced staff training Reduced end-user training Reduced support Identical hardware components Reduced spare part stock Reduced training for service engineers Faster repair Page 34

Modern and easy connection USB Ethernet cable Windows 7 or XP * No old RS-232 cable * Windows 8 compatibility in evaluation Page 35

Electrolytes Not having an ISE module can be an advantage! ISE module - high investment and maintenance for low throughput ISE is inefficient for low throughput Electrolytes can be measured without ISE module Human Reagent (enzym.) : Na, K, Cl, Ca, Mg HumaLyte Plus: Na, K, Cl, Ca Less maintenance, less cost Page 36

No result will be lost Failure proof connection Page 37

Easy maintenance Monitoring of lifetime Pumps Lamp Filters Cuvettes Page 38

Easy maintenance Access to lamp and pumps Lamp Pumps Page 39

Reliable quality High quality components High production depth Made in Europe Extensive testing Page 40

Competitive advantages The slides provided in this section show the advantages of HumaStar 100 and 200 comparing them directly to competitor instruments.

Sample positions 80 60 40 20 0 50 100 150 200 250 300 Throughput max. [t/h] Page 42

A15 A25 Pentra C200 BS-120 Cobas C111 C100 C100plus C200i C200iplus BS-200 Page 43

HumaStar 100 Feature comparison 1 Human HumaStar 100 Horiba Pentra C200 Mindray BS-120 Biosystems A15 Roche Cobas C111 Open/closed Open Closed Open Open Closed Throughput max. 100 t/h const. 90 t/h const. 100 t/h 150 t/h 60 t/h Reagent cooling Yes Yes Yes No Yes Wash station Yes No No No No Sample pos. 60 15 8 48 8 Reagent pos. 30 15x2 * 1 28 20 14x2 * 1 Barcode Internal Internal External? Smp. & Rgt. Primary tubes 16x100 mm Yes Yes 15x100 mm 16x100 mm LIS ASTM Yes Yes Yes ASTM Weight 51 kg 95 kg 75 kg 45 kg 35 kg Water consumpt. < 1 l/h < 2.1 l/h 2.5 l/h 0.5 l/h < 2 l/day ISE No Optional Optional No Optional Cuvettes 80 washable 192 disposable 40 disposable 120 disposable 60 disposable *1 Nbr. of methods X Reag. per method Page 44

HumaStar 100 Feature comparison 2 Human HumaStar 100 Landwind C100 Vital Scientific Pro XS Human HumaStar 80 Open/closed Open Open Open Open Throughput max. 100 t/h const. 150 t/h 75 t/h 80 t/h Reagent cooling Yes Yes Optional No Wash station Yes No No No Sample pos. 60 40 25 54 Reagent pos. 30 40 30 20 Barcode Internal External External External Primary tubes 16x100 mm Yes Yes No LIS ASTM Yes LIS-2A Yes Weight 51 kg 50 kg 67 kg 42 kg Water consumpt. < 1 l/h 3.5 l/h (C100plus) 0.25 l/h ISE None Optional No No Cuvettes 80 washable 81 disposable 48 disposable 144 disp. Comments C100plus with Wash station Batch, Flow-Cell Page 45

HumaStar 200 Feature comparison 1 HumaStar 200 Mindray BS-200 Biosystems A25 Landwind C200i Open/closed Open Open Open Open Throughput max. 200 t/h 200 t/h 240 t/h 225 t/h Reagent cooling Yes Yes Yes Yes Wash station Yes (2 sol.) No No No Sample pos. 60 40 72 60 Reagent pos. 30 40 30 60 Barcode Internal Internal? Optional Primary tubes 16x100 mm Yes 15x100 mm Yes LIS ASTM Yes Yes HL7 Weight 51 kg 116 kg 73 kg 120 kg Water consumpt. < 2 l/h 3.5 l/h (BS-200E) 1 l/h < 1,5 l/h ISE No Optional No Optional Cuvettes 80 washable 80 disposable 120 disposable 81 disposable Comments BS-200E with wash station C200iplus with wash station Page 46

HumaStar 200 Feature comparison 2 HumaStar 200 Elitech Flexor EL80 Elitech Flexor EL150 Elitech Flexor EL200 Open/closed Open Open Open Open Throughput max. 200 t/h 75 t/h 133 t/h 180 t/h Reagent cooling Yes Optional Yes Yes Wash station Yes (2 sol.) No Yes Yes Sample pos. 60 25 25 80 Reagent pos. 30 30 30 32 Barcode Internal Optional external Internal Internal Primary tubes 16x100 mm 13x75 mm 13x75 mm 13x75 mm LIS ASTM LIS-2A LIS-2A LIS-2A Weight 51 kg 67 kg 75 kg 95 kg Water consumpt. < 2 l/h 250 ml/h 950 ml/h 500 ml/h ISE No Optional Optional Optional Cuvettes 80 washable 48 disposable 48 washable 48 washable Comments Integraded PC Integrated PC Page 47

HumaStar 200 Feature comparison 3 HumaStar 200 Roche Cobas C311 DiaSys Respons 910 DiaSys Respons 920 Open/closed Open Closed Closed Closed Throughput max. 200 t/h 300 t/h 150 t/h 200 t/h Reagent cooling Yes Yes No Yes Wash station Yes (2 sol.) Yes No Yes Sample pos. 60 110 30 30 Reagent pos. 30 42 (casseettes) 30 (x2) 30 (x2) Barcode Internal Internal Internal Internal Primary tubes 16x100 mm 16x100 mm 16x100 mm? LIS ASTM Yes (RS 232) Yes Yes Weight 51 kg 270 kg 60 kg 110 kg Water consumpt. < 2 l/h 12 l/h < 1 l/h < 7.5 l/h ISE No Yes No Yes Cuvettes 80 washable Washable 105 disposable 45 washable Comments Page 48

HumaStar 200 Feature comparison 4 HumaStar 200 FUJIFILM NX 500 Miura 200 Open/closed Open Closed Open Throughput max. 200 t/h 128 t/h 240 t/h Reagent cooling Yes Not necessary Yes Wash station Yes (2 sol.) Not necessary Yes (2 sol.) Sample pos. 60 1 49 Reagent pos. 30? 44 Barcode Internal Optional (extern) Optional (Smp&Rgt) Primary tubes 16x100 mm 16x100 mm 13x100 mm LIS ASTM Yes Yes Weight 51 kg 25 kg? Water consumpt. < 2 l/h None < 2 l/h ISE No Yes Optional Cuvettes 80 washable Not necessary 80 washable Comments POCT, dry chem. 1 arm Page 49

HumaStar 100 A15 vs. Page 50

HS100 vs. Biosystems A15 Item Advantage Human Advantage Biosystems A15 Features Equivalent Methods/ Reagents Wash Station (vs. disposable cuvettes) Reagent refrigeration UPS included Sample barcode (especially interesting for LIS) Crash detection of needle Nbr. sample positions (60 vs. 48) Nbr. reagent positions (30 vs. 20) Show complete reaction curve 4 flexible racks for reagents and samples No ISE Primary tubes (16mm vs. 15mm) European origin Open instrument 100 t/h constant vs. 150 t/h max (= ~95 t/h typical) Methods validated One supplier for reagent and instrument Pre-filled in A15 reagent bottles (vs. MPR) Page 51

HS100 vs. Biosystems A15 Advantage HumaStar Explanation The main advantages of HumaStar 100 are the wash station and reagent refrigeration. The wash station saves money and time. Money: A15 has consumable cost for disposable cuvettes. HumaStar can run 30.000 tests with only 80 cuvettes. Time: On A15 manual changing of cuvettes is necessary after a test was run. Reagent refrigeration leads to reliable results, longer on-board and calibration stability. On A15 the user either has to place the reagent in the refrigerator after every run, but he will loose time doing this. If he leaves the reagent on the instrument he will waste reagent when it gets warm and he has to throw it away - he is loosing money. A15 has flexible tray for reagents and samples. However the total number of samples and reagents that the user can place on the instrument is higher on HumaStar. UPS and barcode scanner are included in the standard offer of HumaStar at no extra cost. Equivalent Throughput: A15 has a maximum throughput which is 150 t/h, whereas HumaStar 100 can only reach a maximum of 100 t/h. But the throughput of HumaStar 100 is constant for 1- and 2-shot methods. In a typical mix A15 will only reach 95 t/h. => The throughput is equivalent on both instruments. Biosystems and Human both offer instruments, reagents, and validated methods out of one hand. Advantage A15 Biosystems sells the reagent in bottles that can be placed directly on the instrument. Page 52

HumaStar 100/200 Cobas C111 vs. Page 53

HS100/200 vs. Roche Cobas C111 Item Advantage Human Advantage Roche Cobas C111 Features Wash Station (vs. disposable cuvettes) Big screen A4 printing Nbr. sample positions (60 vs. 8) Up to 30 reagents/methods (vs. 14) Equivalent Methods/ Reagents Throughput Open instrument 100 or 200 t/h (vs. 60 t/h) Reagent cooling Primary tubes Sample barcode reader Pre-installed and validated methods Name and reputation of Roche Small integrated PC, screen and printer ISE (optional) Barcoded reagents in pre-filled bottles 1-5 open channels (optional) Page 54

HS100/200 vs. Roche Cobas C111 Advantage HumaStar Equivalent Advantage Cobas Explanation The main difference is that Cobas C111 is a closed instrument. HumaStar 100/200 are open instruments. The user of HumaStar is not limited in the reagents and methods he wants to use on the instrument. Because Human has also preinstalled and validated methods, Cobas C111 does not have an advantage in that respect. There are three other massive advantages of HumaStar: -On HumaStar the user can place up to 60 samples, whereas only 8 samples can be placed on Cobas C111. This leads to a much a higher walk-away time on HumaStar. -The HumaStar has a wash station, which is much more cost and time efficient than disposable cuvettes on Cobas C111 (for explanation also see Biosystems A15). -HumaStar 100 and 200 are much faster than Cobas C111. The throughput of Cobas is only 60 t/h and much closer to HumaStar 80 than HumaStar 100 or 200. The possibility of automation of the laboratory workflow is equivalent on both instruments. HumaStar and Cobas C111 both can use primary tubes, they both have a built in sample barcode reader, both instruments have a standardized (ASTM) LIS protocol, and both instrument support continuous loading. Roche reagents are ready to use in prefilled and barcode labeled bottles. Handling of reagent bottles is easier. The reputation of Roche is very good. Page 55

HumaStar 200 Cobas C311 vs. Page 56

HS200 vs. Roche Cobas C311 Item Advantage Human Advantage Roche Cobas C311 Features Price of instrument and reagents Low water consumption (<2 vs. 12 l/h) Low energy consumption (<200 vs. 1500 VA) Small footprint (width 69 vs. 134cm) Low weight (51 vs. 270 kg) LIS via RJ-45 (vs. RS-323) No fixed water connection needed Equivalent Methods/ Reagents Throughput Open instrument (50 methods programmable: Human or open channels) Reagent cooling Primary tubes Sample barcode reader Cuvette wash station Pre-installed and validated methods Name and reputation of Roche ISE (optional) Loading STAT and reagents without opening instrument Clot detection More sample positions (110 vs. 60) Barcoded reagents in pre-filled bottles Master-Curve calibration on reagents 42 reagent cassette positions (vs. 30 bottles on HumaStar) 300 t/h (vs. 200 t/h) photometric 180 t/h ISE Page 57

HS200 vs. Roche Cobas C311 Advantage HumaStar Equivalent Advantage Cobas Explanation The main difference is that Cobas C311 is a closed instrument. HumaStar 100/200 are open instruments. No limitations regarding reagents and methods he wants to use. There are three main advantages of HumaStar: -Price of the instrument itself is much lower than C311. -Price of multi-purpose reagents on HumaStar 100/200 is lower than reagents for C311. -No need of a fixed water connection (deionized water)*. -Lower consumption of water. -Lower consumption of energy and takes up less room in the laboratory. Both instruments offers pre-installed and validated methods, which assure reliable results. Roche reagents are ready to use in prefilled and barcode labeled bottles. Handling of reagent bottles and loading of STAT is easier. Throughput of C311 is higher and it can load more reagents (parameters) at the same time. The reputation of Roche is very good. Cobas C311 can benefit most of its advantages an a high throughput laboratory. * Roche also uses water to reconstitute the reagent (high quality necessary) Page 58

HumaStar 100 Pentra C200 vs. Page 59

HS100 vs. Horiba Pentra C200 Item Advantage Human Advantage Pentra C200 Features Wash Station (vs. disposable cuvettes*) Nbr. reagent positions (30 vs. 15x2* 1 ) Nbr. sample positions (60 vs. 15) Less weight (51 vs. 95 kg) Equivalent Methods/ Reagents Open instrument ISE (optional) Integrated computer and screen Cooled sample tray Fixed cycle (const. throughput) 100 vs. 90 t/h Reagent cooling Intuitive touch screen user software Sample barcode included Shock detection of needle Primary tubes Pre-installed and validated methods Barcoded reagents in pre-filled bottles Pentra C200 has192 cuvettes in stock *1 Reagent cassete with R1 and R2 Page 60

HS100 vs. Horiba Pentra C200 Advantage HumaStar Equivalent Advantage Pentra Explanation The main difference is that Pentra is a closed instrument. HumaStar 100/200 are open instruments. The user of HumaStar is not limited in the reagents and methods he wants to use on the instrument. Because Human has also preinstalled and validated methods, Pentra does not have an advantage in that respect. There are two other advantages of HumaStar: -On HumaStar the user can place up to 60 samples, whereas only 15 samples can be placed on Pentra. This leads to a much a higher walk-away time on HumaStar. -The HumaStar has a wash station, which is much more cost and time efficient than disposable cuvettes on Pentra (for explanation also see Biosystems A15). HumaStar 100 and Pentra both have a constant throughput which is approximately equivalent. Reagent cooling, primary tubes, sample barcode reader, and a shock detector are also present on both instruments. Horiba offers reagents that are ready to use in prefilled and barcode labeled bottles. Handling of reagent bottles is easier. PC and monitor are integrated and do not need to be purchased separately. Page 61

HS100 vs. Horiba Pentra C200 Customer claims Pentra has an separate mixing unit. It should be faster. Because Pentra has disposable cuvettes, there is no carry over in the cuvettes. HumaStar 100/200 have washable cuvettes, which will lead to carry over. Possible reply! Pentra and HS100 both work with a fixed cycle. Thus having a fixed throughput for 1- and 2- shot reagents. HumaStar 100 has a 36 sec. cycle: 1 hour/36 sec. = 100 t/h Pentra C 200 has a 40 sec. cycle: 1 hour/40 sec. = 90 t/h => HS100 is even slightly faster than Pentra C200 The washing procedure of HumaStar 100/200 is so sophisticated that carry over is comparable to disposable cuvettes. There are several measures to assure this: 8- step washing of every single cuvette Normal Systemic and a Special Wash solution are connected to the instrument (most other instrument only have one type of wash solution). A third wash solution Cuvette Clean can be programmed in the methods settings if necessary (e.g. turbidimetry). The intensity of the washing can be increased from 1 (normal) to 4 (extended) in the method settings if necessary. The needle is washed internally and externally. Incompatibilities can be defined in the method settings. This will prevent the consecutive execution of parameters that could influence each other in one cuvette. => In practice carry over is comparable on HumaStar and Pentra. HumaStar has the advantage of lower consumable cost (cuvettes). Page 62

HumaStar 100 BS-120 vs. Page 63

HS100 vs. Mindray BS-120 Item Advantage Human Advantage Mindray Features Equivalent Methods/ Reagents Service Comments Wash Station 60 sample positions (vs. 8) Throughput 100 t/h const. (vs. 100 t/h max) Internal sample barcode reader Made in Europe Intuitive touch screen user software Pre-installed and validated method Reagents and instruments from one source Technical service available in most countries Human offers local trainings Optional ISE Reagent cooling Nbr. reagent positions (30 vs. 28) Page 64

HS200 vs. Mindray BS-120 Advantage HumaStar Explanation There are 5 massive advantages of HumaStar 100. -The wash station saves money and time. Money: BS-120 has consumable cost for disposable cuvettes. HumaStar can run 30.000 tests with only 80 cuvettes. Time: manual changing of cuvettes is necessary after a test has been run in a cuvette. -HumaStar 100 is much faster than BS-120. The max. throughput of BS-120 is 100 t/h, but the typical throughput will only be at approx. 60 t/h, because it is not constant for 1- and 2-shot methods. -On HumaStar the user can place up to 60 samples, whereas only 8 samples can be placed on BS- 120. This leads to a much a higher walk-away time on HumaStar. -HumaStar is made in Europe. -HumaStar has pre-installed and validated methods. Users can be sure about the results. On BS- 120 lots of time needs to be spend to reach a precision and performance of parameters as we have on HumaStar 100. Sometimes it will be impossible to reach the performance of HumaStar, because Human has the possibility to adapt the hardware and the software of the instrument to match the reagents. The user in the laboratory does not have this possibility. UPS and barcode scanner are included in the standard offer of HumaStar at no extra cost. The modern user software of HumaStar is easier to use and offers more features than Mindray. Page 65

HS200 vs. Mindray BS-120 Equivalent Advantage BS-120 Explanation Reagent cooling. Number of reagent position is approximately equivalent. Optional ISE. However HumaStar can measure all electrolytes using chemical reagents. ISE modules often require high maintenance if the number of samples that are measured per day is not sufficient. Page 66

HumaStar 200 respons 910 vs. Page 67

HS200 vs. DiaSys respons 910 Item Advantage Human Advantage respons 910 Features Equivalent Methods/ Reagents Throughput Wash Station (vs. disposable cuvettes) UPS included (end user value 720) Reagent refrigeration Open instrument Nbr. sample positions (60 vs. 30) Slightly higher (200 vs. 150 t/h) No ISE module Barcoded primary tubes (16x100mm) European origin Methods validated One supplier for reagent and instrument Nbr. reagent positions (30 vs. 30x2) STAT can be loaded without opening the cover Pre-filled in respons reagent bottles (vs. MPR) Internal reagent barcode reader Page 68

HS200 vs. DiaSys respons 910 Advantage HumaStar Explanation The main advantages of HumaStar 200 is the wash station. The wash station saves money and time. Money: respons 910 has consumable cost for disposable cuvettes. HumaStar can run 30.000 tests with only 80 cuvettes. Depending on your price per disposable cuvette of respons 910, the price per test can be twice as high as on HumaStar 200. Time: manual changing of cuvettes is necessary after a test has been run in a cuvette. UPS is included in the standard offer of HumaStar at no extra cost. HumaStar 200 is an open instruments. The user of HumaStar is not limited in the reagents and methods he wants to use on the instrument. Because Human has also preinstalled and validated methods, respons does not have an advantage in that respect. Reagent refrigeration leads to reliable results, longer on-board and calibration stability. On respons the user either has to place the reagent in the refrigerator after every run, but he will loose time doing this. If he leaves the reagent on the instrument he will waste reagent when it gets warm and he has to throw it away - he is loosing money. Throughput of HumaStar 200 is 50 t/h higher than respons 910. This is difference can make a difference in laboratories with a higher number of samples per day. User can also place 60 samples on HumaStar at the same time. On respons 910 user can only place half of that (30 samples), making HumaStar 200 faster and more suitable if the laboratory has a higher number of samples per day. Page 69

HS200 vs. DiaSys respons 910 Equivalent Advantage respons 910 Explanation DiaSys and Human both offer instruments, reagents, and validated methods out of one hand. DiaSys sells the reagent in bottles that can be placed directly on the instrument and are recognized by an internal barcode reader. On respons 910 user can place up to 30 different parameters, each of them can use up to two reagents. On HumaStar the user can place 30 different bottles. If a parameter uses two reagents it will occupy two positions, thus limiting the number of parameters loaded on the instrument. STAT samples can be loaded on respons 910 without opening the cover. On HumaStar 200 the user needs to press pause and wait for approx. 20 seconds before he can open the cover and place the STAT sample. Page 70

HumaStar 200 respons 920 vs. Page 71

HS200 vs. DiaSys respons 920 Item Advantage Human Advantage respons 920 Features Equivalent Methods/ Reagents Water consumption (2 vs. 7.5 l/h) UPS included (end user value 720) Open instrument Nbr. sample positions (60 vs. 30) Weight (51 vs. 110 kg) Throughput of 200 t/h Cuvette wash station Reagent refrigeration European origin Nbr. reagent positions (30 vs. 30x2) Optional ISE module Methods validated One supplier for reagent and instrument Pre-filled in respons reagent bottles (vs. MPR) Internal reagent barcode reader Page 72

HS200 vs. DiaSys respons 920 Advantage HumaStar Explanation HumaStar 200 is an open instruments. The user of HumaStar is not limited in the reagents and methods he wants to use on the instrument. Users might be limited using respons 920, if they want to measure parameters that are not available from Diasys or reagents cannot be supplied on time. Because Human has also pre-installed and validated methods for its Multi Purpose Reagents, respons does not have an advantage in that respect. User can place 60 samples on HumaStar at the same time. On respons 920 user can only place half of that (30 samples), making HumaStar 200 more suitable if the laboratory has a high number of samples per day. HumaStar 200 is slightly smaller and its weight is only half the weight of respons 920. The water consumption of HumaStar 200 is much lower (< 2 l/h) than the water consumption of respons 920 (< 7.5 l/h) Page 73

HS200 vs. DiaSys respons 920 Equivalent Advantage respons 920 Explanation HumaStar 200 and respons 920 are very similar instruments. Human and DiaSys both supply instrument and validated reagents out of one hand. Thus the user can be sure, to get reliable results. Both instruments have a cuvette wash station and reagent cooling. Both instruments are of European origin, thus having a good reputation in the market. DiaSys sells the reagent in bottles that can be placed directly on the instrument and are recognized by an internal barcode reader. On respons 910 user can place up to 30 different parameters, each of them can use up to two reagents. On HumaStar the user can place 30 different bottles. If a parameter uses two reagents it will occupy two positions, thus limiting the number of parameters loaded on the instrument. Respons 920 has an optional ISE module for Na, K, Cl, Li. Page 74

HumaStar 200 A25 vs. Page 75

HS200 vs. Biosystems A25 Item Advantage Human Advantage Biosystems A25 Features Wash Station (vs. disposable cuvettes) UPS included (end user value 720) Sample barcode included (value > 500) (especially interesting for LIS) Shock detection of needle Show complete reaction curve Intuitive touch screen user software 3 independent sample racks Equivalent Nbr. sample positions (60 vs. 72), nbr. reagent positions (30 vs. 30) No ISE Primary tubes (16mm vs. 15mm) European origin Reagent refrigeration Open instrument Methods/ Reagents Throughput Methods validated One supplier for reagent and instrument Pre-filled in A25 reagent bottles (vs. MPR) Slightly higher (200 vs. 240 t/h) Page 76

HS200 vs. Biosystems A25 Advantage HumaStar Equivalent Advantage A25 Explanation The main advantages of HumaStar 200 is the wash station. The wash station saves money and time. Money: A25 has consumable cost for disposable cuvettes. HumaStar can run 30.000 tests with only 80 cuvettes. Time: manual changing of cuvettes is necessary after a test has been run in a cuvette. UPS and barcode scanner are included in the standard offer of HumaStar at no extra cost. The modern user software of HumaStar is easier to use and more intuitive (see screen shots on next slide). Biosystems and Human both offer instruments, reagents, and validated methods out of one hand. Number of samples and reagents are approximately equivalent. On HumaStar you can place primary tubes up to 16 mm, on A25 you can place primary tubes up to 15 mm. Biosystems sells the reagent in bottles that can be placed directly on the instrument. Throughput of A25 is 20% higher than HumaStar 200. However, in routine use this difference will not be noticed by the user. Page 77

Page 78 HS200 vs. Biosystems A25

HumaStar 200 BS-200 vs. Page 79

HS200 vs. Mindray BS-200 Item Advantage Human Advantage Mindray Features Equivalent Service Methods/ Reagents Comments Cuvette Wash Station 60 sample positions (vs. 40) UPS included Made in Europe Easy to use software Less weight (51 vs. 116 kg) Less water consumption (< 2 l/h vs. 3.5 l/h) Optional ISE 40 reagent positions (vs. 30) Throughput 200 t/h (even though Mindray has extra mixer) Reagent cooling Technical service available in most countries Human offers local trainings Methods validated One supplier for reagent and instrument BS-200E with Wash Station Page 80

HS200 vs. Mindray BS-200 Advantage HumaStar Equivalent Advantage BS-200 Explanation -If competing against BS-200 (not BS-200E): The wash station saves money and time. (see also A15 for explanation). If competing against BS-200E: The water consumption on HumaStar is lower. -On HumaStar the user can place up to 60 samples, whereas only 40 samples can be placed on BS-200. -HumaStar is made in Europe. -HumaStar has pre-installed and validated methods. (see also BS-120 for explanation) -UPS and barcode scanner are included in the standard offer of HumaStar at no extra cost. -The modern user software of HumaStar is easier to use and offers more features than Mindray. -The weight of HumaStar is only half the weight of BS-200. Throughput: The throughput on both instruments is approximately the same. Reagent cooling. Optional ISE. However HumaStar can measure all electrolytes using chemical reagents. ISE modules often require high maintenance if the number of samples that are measured per day is not sufficient. Number of reagent position is slightly higher. However multiple reagent trays can be handled (saved) by HumaStar. Page 81

HumaStar 200 LW C200i vs. Page 82

HS200 vs. Landwind C200i Item Advantage Human Advantage Landwind C200i Features Equivalent Service Methods/ Reagents Comments Cuvette wash station Barcode scanner included UPS included Easy to use software Made in Europe Less weight (51 vs. 116 kg) Human can offer technical service in most countries Human offers local trainings Pre-installed and validated method Reagents and instruments from one source Reagent cooling 60 sample positions Optional ISE 60 reagent positions (vs. 30) Slightly higher throughput (225 vs. 200 t/h) C200iplus with wash station (6 l/h) Page 83

HS200 vs. Landwind C200i Advantage HumaStar Equivalent Advantage BS-200 Explanation -If competing against C200i (not C200iplus): The wash station saves money and time. (see also A15 for explanation). If competing against C200iplus: The water consumption on HumaStar is lower. -HumaStar is made in Europe. -HumaStar has pre-installed and validated methods. (see also BS-120 for explanation) -UPS and barcode scanner are included in the standard offer of HumaStar at no extra cost. -The modern user software of HumaStar is easier to use and offers more features than Landwind. Landwind software is very difficult to use. -The weight of HumaStar is only half the weight of C200i. Reagent cooling. Number of sample positions. The throughput is slightly higher on C200i. Optional ISE. However HumaStar can measure all electrolytes using chemical reagents. ISE modules often require high maintenance if the number of samples that are measured per day is not sufficient. Number of reagent position is higher. However multiple reagent trays can be handled (saved) by HumaStar. Page 84

HumaStar 200 NX 500 vs. Page 85

HS200 vs. FUJIFILM NX 500 Item Advantage Human Advantage NX 500 Features Equivalent Service Methods/ Reagents Open instrument A4 printout 60 sample positions (vs. 1) Lower price per test More than 40 Human parameters preinstalled Can be used with other reagents that are available on the market No calibration necessary No water consumption Compact and light weight Optional plasma filter (whole blood) 28 + 3 parameters FUJIFILM dri-chem reagent slides ONLY Comments Suited for central or hospital laboratories Dry chemistry POCT suited for physician's offices Page 86

HS200 vs. FUJIFILM NX 500 Advantage HumaStar Equivalent Advantage NX 500 Explanation -The HumaStar is an instrument suited for a central or hospital laboratory. It can load and run up to 60 samples at once. NX 500 can only run one sample at a time. NX 500 is a designated POCT instrument for physician s offices or similar operation areas which run only very few samples. HumaStar also has an internal sample barcode reader, NX 500 only has an optional handheld scanner. -Price per test is much lower on HumaStar than on NX 500. NX 500 is optimized for easy operation, not for low cost or higher throughput. On NX 500 disposable consumables are used for plasma separation and pipetting (-> waste and cost). -HumaStar comes with more pre-installed parameters than NX 500. Some parameters, such as HbA1c are not available on NX 500. HumaStar is also an open system, you can use most clinical chemistry reagents that are available on the market. On NX500 you can only run the dry reagent slides which are provided by Fujifilm. -Easy operation: No on-site calibration necessary, no centrifugation of sample necessary. -Small footprint and low weight: Integrated computer and thermal printer. Page 87

Customer feedback

Customer feedback After the training we have asked the participating engineers what they think about the new instruments. Here are some answers: Topic Question Result/Comments General impression Advantages What will be your selling arguments to convince your customers of the instrument? Content with performance and quality For medium laboratory it will be a success 2x Made in Germany, Reliable results Robust and stable/walk away 3x Excellent, Easy to use/user friendly software, Software interchangeable between HS100 and HS200 2x Instr. continues operation when disconnected 2x Reusable cuvettes 2x Open system Throughput 4 different reagent vials Design Power independent refrigeration Easy maintenance and easy control of condition of pumps and other parts, Lamp change Page 89

Product features The slides provided in this section present the HumaStar 100 and HumaStar 200 features. They can be used for a more detailed presentation of the product.

HumaStar 100 & 200 Product features 1. Design 2. Technology Main Features Hardware and Software Service and Maintenance Page 91

HumaStar 100 & 200 Our Pioneers for a new Line of Instruments Page 92

HumaStar 100 & 200 Product features 1. Design 2. Technology Main Features Hardware and Software Service and Maintenance Page 93

HumaStar 100 & 200 Maximum - Single Shot Throughput 80 t/h 100 t/h 180 t/h 200 t/h 200 t/h Throughput Maximum 100 t/h 0 t/h HumaStar 80 HumaStar 100 HumaStar 180 HumaStar 200 Page 94

100 t/h HumaStar 100 & 200 Throughput 100 t/h Maximum - Single Shot Double Shot Reagents 200 t/h Throughput Double Shot 100 t/h 0 t/h HumaStar 80 HumaStar 100 HumaStar 180 HumaStar 200 Page 95

HumaStar 100 & 200 Throughput 200 t/h Maximum - Single Shot Double Shot Reagents Typical Mix Throughput Typical 100 t/h 100 t/h 115 t/h 127 t/h 0 t/h 40 t/h HumaStar 80 HumaStar 100 HumaStar 180 HumaStar 200 * independent of single- or double shot methods Page 96

HumaStar 100 & 200 Features Open random-access Multi-step wash station Primary tubes (16x100 mm) Sample cups Reagent cooling 30 reagent and 60 sample positions Internal sample barcode reader Needle shock detector Bi-directional LIS (ASTM) Continuous loading Page 97

HumaStar 100 & 200 Product features 1. Design 2. Technology Main Features Hardware and Software Service and Maintenance Page 98

HumaStar 100 & 200 Wash Station 8-step wash cycle 2 nd cleaning solution Level sensors for all containers Difference HumaStar 100 vs. 200 6 vs. 8 cleaning needles Water consumption only 8 ml per test Page 99

HumaStar 100 & 200 Samples Removable sample tray Primary tubes and cups 60 positions up to 12.5x100 mm Optional tray: 20+20 positions up to 16x100 mm Internal barcode reader included Page 100

HumaStar 100 & 200 Reagents HUMAN methods pre-installed and validated Substrates, enzymes, turbidimetry, electrolytes Open analyzer Removable reagent tray Reagent cooling 30 positions (one used for diluent) 4 different reagent vials Page 101

HumaStar 100 & 200 Electrolytes ISE module - high investment and maintenance ISE inefficient for low to medium throughput No optional ISE module Human Reagent or HumaLyte Plus Human Reagent: Na, K, Cl, Ca, Mg HumaLyte Plus: Na, K, Cl, Ca Page 102

HumaStar 100 & 200 Product features 1. Design 2. Technology Main Features Hardware and Software Service and Maintenance Page 103

HumaStar 100 & 200 User Interface and Features Page 104

HumaStar 100 & 200 User Interface and Features Easy to use Touch screen Page 105

HumaStar 100 & 200 User Interface and Features Easy to use Touch screen 5 main tabs One software - Complete analyzer line Page 106

HumaStar 100 & 200 Extensive Information Reaction charts Page 107

HumaStar 100 & 200 Extensive Information Reaction charts Quality control charts Page 108

HumaStar 100 & 200 Extensive Information Reaction charts Quality control charts Method statistics Page 109

HumaStar 100 & 200 Ext. Computer and LIS LIS HumaStar PC via USB ASTM standard Bi-Directional Page 110

HumaStar 100 & 200 Product features 1. Design 2. Technology Main Features Hardware and Software Usability and Safety Service and Maintenance Page 111

HumaStar 100 & 200 Minimum Maintenance Monitoring of life time Pumps Page 112

HumaStar 100 & 200 Minimum Maintenance Monitoring of life time Pumps Filters Lamp Page 113

HumaStar 100 & 200 Minimum Maintenance Monitoring of life time Pumps Filters Lamp Cuvettes Page 114

HumaStar 100 & 200 Minimum Service Quality High quality components High production depth Made in Europe Extensive testing Easy access Page 115

HumaStar 100 & 200 Minimum Service Quality Easy access Lamp Page 116

HumaStar 100 & 200 Minimum Service Quality Easy access Lamp Peristaltic pumps Page 117

HumaStar 100 & 200 Minimum Service Quality Easy access Lamp Peristaltic pumps Remove top cover Page 118

HumaStar 100 & 200 Minimum Service Quality Easy access Lamp Peristaltic pumps Remove top cover Remove complete cover Page 119

52 cm HumaStar 100 & 200 Size and Weight 169 cm 76 cm 69 cm 51 kg Page 120

The end

We need your help! We have tried to collect and summarize the information of this presentation as carefully as possible. However we cannot take responsibility for the accuracy of the information, especially for information about competitor instruments. If you find any error in the presentation, if you have additional information, field reports or arguments, please send this information to: f.schardt@human.de If you have prices of competitor instruments available please send them to us, indicating if it is a distributor or end user price. Also indicate any optional accessories (UPS, barcode, ISE, computer, ) which is included in the price. We depend on your knowledge to improve this presentation. You are much closer to the market and have better information than we do. By sharing this information you can help the worldwide Human-Family! Thanks Page 122

Page 123 Get in the race and ask for more information about HumaStar 100 and 200.