Hôpital Saint-Louis - Paris, France

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- Paris, France General Information New breast cancer cases treated per year 800 Breast multidisciplinarity team members 13 Radiologists, surgeons, pathologists, medical oncologists, radiotherapists and nurses Clinical Director: Marc Espié, MD The breast disease centre of Saint-Louis hospital was set up in the late 70s. It groups all the specialists and nurses involved in mastology together in one and the same place. 12,000 medical consultations are given there every year. In addition to the management of patients, we carry on training and research activities. We have established a university diploma in breast diseases and published a work entitled Le Sein (the Breast), ESKA publishing house, a book of reference in French, covering all mastology fields. Every year, we organize a congress: the Saint Louis Hospital Interactive Mastology Conference. We have set up an all-embracing network of care provision: Saint-Louis breast network (http:www//saint-louis-reseau-sein.org) ensuring alternate monitoring between private practice and hospital and offering supportive care to patients. Hôpital Saint-Louis 1 Avenue Claude Vellefaux 75010 Paris, France Phone: +33142499293 Fax: +33142494473 E-mail: marc.espie@sls.aphp.fr Web-site: www.centre-maladies-sein-saint-louis.org 1/6

Available services Reconstructive/Plastic Surgery Nuclear Medicine Rehabilitation Genetic Counselling Data Management Psycho-oncology Breast Nurses Social Workers Nutritional Counselling Survivorship Groups Sexual Health Counselling Supportive and Palliative Care Integrative Medicine Dedicated Radiologists 2 Mammograms per year 3000 Breast radiographers Screening program Verification for non-palpable breast lesions on specimen Axillary US/US-guided FNAB Available imaging equipment Mammography Ultrasound Magnetic Resonance Imaging (MRI) Available work-up imaging equipment Computer Tomography Ultrasound Magnetic Resonance Imaging (MRI) PET/CT scan Primary technique for localizing non-palpable lesions Hook-wire (or needle localization) Charcoal marking/tattooing ROLL: radio-guided occult lesion localization Available breast tissue sampling equipment Stereotactic Biopsy (Mammography guided) Core Biopsy (Tru-cut) Vacuum assisted biopsy Ultrasound-guided biopsy Fine-needle aspiration biopsy (FNAB, cytology) Core Biopsy Vacuum assisted biopsy MRI-guided biopsy Core Biopsy Vacuum assisted biopsy New operated cases per year (benign and malignant) 1200 Dedicated Breast Surgeons 2 Surgeons with more than 50 surgeries per year 4 beds 20 Breast Nurse specialists 1 Outpatient surgery Intra-operative evaluation of sentinel node Reconstruction performed by Breast Surgeons Primary technique for staging the axilla Axillary lymph node dissection Sentinel lymph node biopsy: Blue dye technique Radio-tracer technique Blue dye + Radio-tracer Axillary sampling 2/6

Reconstructive/Plastic Surgery Reconstructive/Plastic surgeons 2 Immediate Reconstruction available Type of breast reconstructive surgery available Remodelling after breast-conserving surgery Reconstruction after mastectomy: Two-stage reconstruction (tissue expander followed by implant) One-stage reconstruction Autogenous tissue flap Latissimus dorsi flap Transverse rectus abdominis (TRAM) Free-flaps (free TRAM, DIEP, SIEA, gluteal, etc.) Surgery on the contralateral breast for symmetry lipofilling Dedicated Breast Pathologists 2 Available studies Cytology Haematoxylin & eosin section (H&E) Surgical specimen Sentinel node Core biopsy Frozen section (FS) Surgical specimen Sentinel node Immunohistochemistry stain (IHC) Estrogen receptors Progesterone receptors HER-2 Ki-67 Other special studies available Fluorescence in-situ Hybridization for HER-2 gene (FISH) Oncotype Dx (21-gene assay) MammaPrint (70-gene microarray) Prediction Analysis of Microarray 50-gene set (PAM 50) P53, SISH Parameters included in the final pathology report stage (pt and pn) Tumour size (invasive component in mm) Histologic type Tumor grade ER/PR receptor status HER-2/neu receptor status Peritumoural/Lymphovascular invasion Margin status Dedicated Breast Medical Oncologists 4 Outpatient systemic therapy 3/6

Dedicated Radiation Oncologists Available techniques after breast-conserving surgery (including experimental) Whole-Breast RT (WBRT) Partial breast irradiation (PBI): External beam PBI Interstitial brachytherapy Targeted brachytherapy (MammoSite, SAVI applicator, other devices) Intra-operative RT (IORT) Multidisciplinary Meeting (MDM) / Tumour Board (TB) Regular MDM/TB for case management discussion Twice a week Weekly Every two weeks Other Schedule Cases discussed at MDM/TB Preoperative cases Postoperative cases Specialties/services participating in MDM/TB Reconstructive/Plastic Surgery Genetic Counselling Breast Nurse Service Psycho-oncology Further Services and Facilities Nuclear Medicine Lymphoscintigraphy Bone scan Positron Emission Tomography (PET) PET/CT scan Rehabilitation Prosthesis service Physiotherapy Lymph-oedema treatment aesthetic counselling Genetic Counselling Specialist Providing Genetic Counselling/Risk assessment service: Dedicated Clinical Geneticist Medical Oncologist Breast Surgeon General Surgeon Gynaecologist Genetic Testing available Surveillance program for high-risk women Data Management Database used for clinical information Data manager available 4/6

Contact details Clinical Director Marc Espié, MD Associate Professor marc.espie@sls.aphp.fr +33142499293 Marcella Albiter, MD Breast Radiologist marcella.albiter@sls.aphp.fr +33142494949 Cedric De Bazelaire, MD Breast Radiologist cedric.de-bazelaire@sls.aphp.fr +33142494949 Edwige Bourstyn, MD Breast Surgeon edwige.bourstyn@sls.aphp.fr +33142494949 Laurence Cahen Doidy, MD Breast Surgeon laurence.cahen-doidy@sls.aphp.fr +33142494949 Reconstructive Surgery Jean Masson, MD Breast Plastic Surgeon jean.masson@sls.aphp.fr +33142494949 Camille Ozil Staff Surgeon camille.ozil@sls.aphp.fr +33142494949 Anne de Roquancourt, MD Associate Professor anne.de-roquancourt@sls.aphp.fr +33142494949 Philippe Bertheau, MD, PhD Professor philippe.bertheau@sls.aphp.fr +33142494949 Caroline Cuvier, MD Breast Medical Oncologist caroline.cuvier@sls.aphp.fr +33142494949 Sylvie Giacchetti, MD Breast Medical Oncologist sylvie.giacchetti@sls.aphp.fr +33142494949 Luis Teixeira, PhD luis.teixeira@sls.aphp.fr +33142494949 Christophe Hennequin Head of Dpt. christophe.hennequin@sls.aphp.fr +33142494949 5/6

How to reach us Hôpital Saint-Louis 1 Avenue Claude Vellefaux 75010 Paris, France Phone: +33142499293 Fax: +33142494473 E-mail: marc.espie@sls.aphp.fr Web-site: www.centre-maladies-sein-saint-louis.org From airport: By subway or bus from Charles de Gaulle airport or from Orly airport. By train: Gare de l'est or Gare du Nord. By bus or sub-way/underground: Subway stations: Goncourt, Bonsergent, Gare de l'est or République. Bus lines 46 or 75. By car: 1 avenue Claude Vellefaux - 75010 - Paris, France Last modified: 15 January 2016 6/6