Leading causes of death in Israel

www.health.gov.il Health Information Division Leading causes of death in Israel 2000-2012 Nehama Goldberger, Myriam Aburbeh, Ziona Haklai September 2015 Health.info@moh.health.gov.il

Contents Leading causes of death in Israel summary... 1 Trends... 1 International Comparison... 3 Ranking of leading causes of death in Israel by age... 6 Multiple causes of death... 9 Tables - Leading causes of death by year... 10 Appendix detailed cause of death, 2012... 28

Leading causes of death in Israel - summary The publication Leading causes of death, 2000-2012 presents trends in mortality rates by cause of death, age, gender and year in the last decade, international comparisons with Europe, Canada and the USA, and follows the methodology of the USA publications on leading causes of death 1. The publication was prepared by the Health Information Division of the Ministry of Health and is a continuation of a series of publications on this subject. The information is based on the notification of death form legally required by the Ministry of the Interior. The coding of death causes is done by the Central Bureau of Statistics (CBS), based on this form and supplementary information from other data sources. This notification of death form includes the immediate cause of death, the train of events that led to this cause, and other significant diseases, conditions or injuries that contributed to death but not directly resulting in previous chain of events. Data is presented here on the underlying cause of death, defined as the cause that initiated the train of events leading to death, or the circumstances of the accident or violence that produced the fatal injury, and chosen by the CBS from the causes written by the doctor on the notification of death form according to definitions and conventions of the International Classification of Diseases. In addition, data is presented on multiple causes of death, which include all causes mentioned on the death notification. Trends In the last decade, rates of death from most causes have been decreasing. Crude total mortality decreased by about a tenth between 2000 and 2012, by 14% for males and 9% for females. Cancer is the leading cause of death from 1999 in both genders, followed by heart disease. For most of the period, 1999-2012, cerebrovascular disease was the third and diabetes the fourth cause. These four causes together accounted for about half of all deaths in 2012 (53% for males, 52% for females), compared to a higher proportion in 2000 (57% for males, 60% for females). The average crude mortality rate for 2010-2012 showed a significant decrease compared to 1999-2001 of about a third for heart disease (35% for males, 32% for females), and about a quarter for cerebrovascular disease (27% for males, 23% for females) and diabetes (22% for males, 25% for females). Deaths from accidents decreased by about a third for males (35%) and 17% for females. The mortality rate decreased for chronic lower respiratory disease (CLRD) by about a fifth over this period (19% for males, 23% for females). However, an increase in crude mortality rate for 2010-2012 compared to 1999-2001 was found for other causes. The highest increase was for dementia, which more than doubled, an increase of 111% for males and 116% for females. Other high increases were for mortality due to septicemia (71% for both genders), Alzheimer s disease (57% for males, 78% for females), influenza and pneumonia (13% in males, 25% in females), pneumonitis due to solids and liquids (30% in males, 49% in females). Mortality rates from kidney disease rose till 2006, but were somewhat lower and stable in the following years 1 http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_06.pdf Leading causes of death in Israel, 2000-2012 1

Trends Mortality Rates by cause, 1999-2012 3- year moving average/100,000 population Males Females 160 140 120 100 80 60 40 20 0 160 140 120 100 80 60 40 20 0 Malignant Cerebrovascular disease Diabetes Kidney disease Malignant Cerebrovascular disease Diabetes Dementia Kidney disease 3- year moving average mortality rate: Percentage change between 1999-2001 and 2010-2012 Males Females Malignant -4% Malignant -5.4-35% -28.5 Cerebrovascular disease Diabetes Kidney disease -27% -22% 6% Cerebrovascular disease Diabetes Dementia -25.2-24.2 67.8 144.1 71% Kidney disease -6.0 2 Ministry of health, Israel

International Comparison The age adjusted mortality rate in Israel was low in comparison to the USA and most European countries. In 2012, the rate in Israel was 928 per 100,000 population, compared to a similar rate in Italy (923) and lower rates in France (871), Canada (881), Switzerland (882) and Spain (898). In 17 other selected European countries and in the USA, rates were higher. Amongst males, Israel had the lowest mortality rate of all European countries (1,068), with a lower rate only in Canada (1,051), while amongst females, Israel s rates were 5 th lowest in Europe (814), after France (669), Spain (703), Switzerland (739), Italy (755) and also Canada (748). Age adjusted* mortality rates per 100,000 population by country, 2012 Total Males Females France** 871.0 Canada** 1,051.5 France** 669.2 Canada** 880.5 Israel 1,068.4 Spain 702.8 Switzerland 881.7 Switzerland 1,086.3 Switzerland 739.5 Spain 898.4 United Kingdom 1,156.6 Canada** 748.5 Italy 922.6 France** 1,158.0 Italy 754.9 Israel 927.5 Spain 1,162.1 EU-15 countries 793.5 EU-15 countries 962.3 Italy 1,167.4 Israel 814.1 Sweden 975.9 Sweden 1,173.3 Finland 824 United Kingdom 998.1 EU-15 countries 1,190.9 Sweden 834.2 Norway 999.1 Germany 1,196.8 Portugal 839 Germany 1003.2 Norway 1,211.3 Germany 844.1 Austria 1014.4 USA 1,235.9 Austria 844.9 Netherlands 1017.5 Netherlands 1,237.2 Norway 845.9 Finland 1027.1 Greece 1,243.7 Belgium 859.9 Ireland 1028.0 Austria 1,257.3 Ireland 860.2 Greece 1042.7 Ireland 1,259.6 Netherlands 869.6 USA 1049.1 Denmark 1,316.3 Greece 872.3 Belgium 1050.6 Finland 1,319.5 United Kingdom 872.8 Portugal 1052.1 Belgium 1,321.4 USA 900.8 Denmark 1087.9 Portugal 1,349.9 Denmark 926.6 Czech Republic 1323.3 Czech Republic 1,656.3 Poland 1,030.5 Poland 1328.3 Poland 1,767.0 Czech Republic 1,088.4 Slovak Republic 1460.8 Slovak Republic 1,862.3 Slovak Republic 1,186.1 Hungary 1502.9 Hungary 1,939.7 Hungary 1,215.1 Romania 1601.8 Romania 1,985.5 Romania 1,312.8 *Adjusted to the new European Standard Population defined by Eurostat, 2012 ** 2011 data Leading causes of death in Israel, 2000-2012 3

International comparison - Ranking of causes of death Cancer was the leading cause of death in Israel in 2012, and heart disease the second ranking cause, as in the USA, Canada and most West European countries, other than Finland, Germany, Sweden, Austria and Greece where the rank was reversed. The third cause of death in Israel was cerebrovascular disease, as in the average of the 15 Western EU countries, but the 4 th cause was diabetes, which had a similar rank only in Austria, was ranked 5 th in Italy and Portugal, 6 th in Germany and 7 th or higher in the USA, Canada and other European countries. Dementia, recently added to the Eurostat database was amongst the 5 leading causes in several countries, ranking 3 rd in Holland and Canada, 4 th in the USA, UK and Sweden, and 5 th in Norway, Denmark, Germany, Spain and for the 15 EU country average, but only 8 th in Israel. Accidents were the 3 rd ranked cause in the USA and France, and 4 th in the 15 EU countries, while only 8 th in Israel. CLRD were the 3rd cause in the USA, 4 th for the 15 EU countries and 4 th or 5 th for most European countries while only 7 th in Israel. However septicemia, which is an increasing cause in Israel, was ranked 5 th, while it was not amongst the 10 leading causes in most countries. Ranking of 10 leading causes of death comparison with the USA, Canada and Europe Rank Israel EU-15 countries USA Canada 1 Malignant Malignant Malignant 2 Malignant 3 Cerebrovascular disease Cerebrovascular disease CLRD Dementia 4 Diabetes CLRD Dementia Cerebrovascular disease 5 Dementia Cerebrovascular disease CLRD 6 Kidney disease Accidents Accidents Accidents 7 CLRD Pneumonia & Influenza Alzheimer's disease Diabetes 8 Dementia Diabetes Diabetes Alzheimer's disease 9 Pneumonia & Influenza Alzheimer's disease Pneumonia & Influenza Pneumonia & Influenza 10 Accidents Kidney disease Kidney disease Kidney disease Sources of data: Eurostat database http://ec.europa.eu/eurostat/data/database Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2013 on CDC WONDER Online Database, released 2015. Accessed at http://wonder.cdc.gov/ucd-icd10.html. Statistics Canada. Table 102-0551 - Deaths and mortality rate, by selected grouped causes, age group and sex, Canada, annual. http://www5.statcan.gc.ca/cansim/home-accueil?lang=eng&p2=49&mm EU-15 countries: A population weighted average including: Austria, Italy, Ireland, Belgium, United Kingdom, Germany, Denmark, Netherlands, Greece, Luxembourg, Spain, Portugal, Finland, France and Sweden. 4 Ministry of health, Israel

International comparison - Mortality rates by cause of death The age adjusted mortality rate was low in Israel compared to the USA, Canada and most European countries for cancer, heart disease, liver diseases, Alzheimer disease, accidents and suicide and lower than most European countries for cerebrovascular disease. But it was higher for septicemia, diabetes, kidney disease, and hypertension, 5.2, 2.4, 3.1 and 2.0 times higher respectively than the 15 EU country average. Mortality rates per 100,000 population by causes of death, 2012 Rate ratio EU-15 countries/israel rates 0.9 Malignant 0.7 0.8 Cerebrovascular disease 0.8 CLRD 0.8 Dementia 0.7 Accidents 0.8 Pneumonia & Influenza 2.4 Diabetes 0.7 Alzheimer's disease 3.1 Kidney disease 0.5 Chronic liver disease 0.7 Suicides 2.0 Hypertension 0.7 Parkinson disease 5.2 Age adjusted* mortality 46 21 28 22 23 27 37 13 20 19 39 13 13 6 12 14 7 11 12 16 8 11 6 8 55 58 73 62 29 36 59 27 35 31 53 22 15 40 8 150 USA Israel 242 233 260 221 252 EU-15 countries *Adjusted to the new European Standard Population defined by Eurostat, 2012 Leading causes of death in Israel, 2000-2012 5

Ranking of leading causes of death in Israel by age On average in 2010-2012, cancer was the leading underlying cause of death for total deaths, and amongst females aged 25-74 and males over 25. was the leading cause for females over 75, and the second cause for males over 45 and females aged 45-74. For both genders, accidents were the leading cause for age 15-24 and the second cause for 25-44. Suicide was the second cause of death for males aged 15-24, and the 3 rd cause for males aged 25-44 and females aged 15-44. All ages: In recent years, about a quarter of all male and female deaths in Israel were from cancer, and a fifth from heart disease. The 3 rd and 4 th causes were cerebrovascular disease and diabetes, whose rates have been similar in recent years, and the following cause was kidney disease. These five leading causes account for about 60% of all deaths in recent years. Age 0-4: In 2012, conditions of the perinatal period (perinatal) and congenital malformations, deformations and chromosomal abnormalities (congenital conditions) were the leading causes, followed by accidents. These causes accounted for about 70% of deaths at this age. Age 5-14: Accidents and cancer were the leading causes for boys in 2012, while they had the opposite ranking for girls. For boys the 3 rd cause was congenital conditions, with the same number of deaths as accidents for girls. Age 15-24: In 2012, the external causes of accidents, suicide and homicide were the 3 leading causes for boys. For girls, too, accidents were the leading cause followed by cancer (4 th for boys) and suicide. Age 25-44: Cancer was the leading cause for both genders in 2012, suicide 2 nd and accidents 3 rd for males, with the reverse ranking for females, followed by heart disease 4 th and homicide 5 th for both genders. Amongst males, poisoning with undetermined intent was the next cause, which may be connected with drug abuse. Age 45-74: The 3 leading causes for both genders in 2012 were the same: cancer, heart disease, and diabetes while cerebrovascular disease was the 4 th cause for females aged 45-74 and males aged 65-74. Suicide was the 4 th cause for males aged 45-64 and accidents the 5 th cause, while for females the 5 th cause was CLRD. For ages 65-74 kidney disease was the 5 th cause for males and septicemia the 6 th with the reverse ranking for females. Age 75 and over: In 2012, cancer was the leading cause for males and heart disease the second, the ranking was reversed for females. Cerebrovascular disease was the 3 rd cause for both genders, kidney disease 4 th for males and diabetes 4 th for females and 5 th for males. ranked 5 th for females and 6 th for males. Dementia, a disease which has increased considerably as underlying cause in recent years, was 6 th for females. 6 Ministry of health, Israel

Ranking of 10 leading causes, by age, 2010-2012 - Males Absolute numbers and rate per 100,000 population Rank Total 0-14 15-24 25-44 45-64 65-74 75+ 1 2 3 4 5 6 7 8 9 10 Kidney disease 2,509 21.8 2,053 17.8 Accidents 2,048 17.8 CLRD 1,982 17.2 Pneumonia & influenza 1,316 11.4 Dementia 1,096 9.5 29 0.9 Pneumonia & influenza 17 ( 0.5) Homicide 15 ( 0.4) 10 ( 0.3) - Cerebrovascular disease - Other - Meningitis 6 ( 0.2) Accidents 252 13.8 Suicides 136 7.5 Homicide 86 4.7 Malignant 80 4.4 23 1.3 - Poisoning undetermined intent - War/Terror 10 ( 0.5) Congenital conditions 9 ( 0.5) 7 ( 0.4) Pneumonia & influenza 6 ( 0.3) Malignant 474 15.1 Accidents 357 11.3 Suicide 352 11.2 174 5.5 Homicide 158 5.0 Poisoning undetermined intent 67 2.1 Cerebrovascular disease 577 101.1 CLRD 407 71.3 Cerebrovascular disease 34 1.1 Substance abuse 31 1.0 Chronic liver disease 28 1.1 Diabetes 26 0.8 Malignant 3,879 176 1, 374 63.0 Diabetes 501 23.0 Accidents 356 16.3 Kidney disease 238 10.9 225 10.3 CLRD 212 9.7 Chronic liver disease 164 7.5 Malignant 3,785 663.2 1,665 291.7 Diabetes 683 119.7 Malignant Perinatal causes 436 15, 800 13.0 137.0 Congenital 10,089 conditions 87.5 360 10.7 Cerebrovascular 142 disease 4.2 Accidents 3, 238 28.1 Diabetes Malignant 3,112 27.0 87 2.6 Cerebrovascular disease 379 17.4 Suicide 363 16.6 Kidney disease 397 69.6 303 53.1 Accidents 200 35.0 Pneumonia & influenza 181 31.7 Chronic liver disease 117 20.5 Malignant 7,495 1,660.8 6,824 1,512.1 Cerebrovascular disease 2,238 495.9 Diabetes 1,901 421.2 Kidney disease 1,852 410.4 1,490 330.2 CLRD 1,345 298.0 Dementia 991 219.6 Pneumonia & influenza 983 217.8 Accidents 741 164.2 Leading causes of death in Israel, 2000-2012 7

Ranking of 10 leading causes, by age, 2010-2012 - Females Absolute numbers and rate per 100,000 population Rank Total 0-14 15-24 25-44 45-64 65-74 75+ 1 2 3 4 5 6 Malignant 15,508 131.7 Heart disease 10,055 85.4 Cerebrovascular d. 3,977 33.8 Diabetes 3,645 31.0 2,368 20.1 Kidney Disease 2,186 18.6 Perinatal 351 11.0 Congenital conditions 333 10.4 Accidents 75 2.2 Malignant 64 2.0 27 0.8 14 (0.4) Accidents 55 3.1 Malignant 49 2.8 Suicide 35 2.0 12 ) 0.7( Congenital conditions 10 ( 0.6) Homicide 8 ( 0.5) Malignant 630 19.9 Accidents 97 3.1 Suicide 74 2.7 Heart disease 53 1.7 Homicide 38 1.2 19 (0.6) Malignant 3,710 158.6 415 17.7 Diabetes 258 11.0 Cerebrovascular d. 211 9.0 Accidents 131 5.6 119 5.1 Malignant 3,256 486.0 837 124.9 Diabetes 550 82.1 Cerebrovascular d. 396 59.1 Kidney disease 243 36.3 225 33.6 8,711 1,322.9 Malignant 7,799 1,184.4 Cerebrovascular d. 3,351 508.9 Diabetes 2,821 428.4 Dementia 2,010 305.2 1,988 301.9 7 8 9 10 Dementia 2,095 17.8 CLRD 1,632 13.9 Pneumonia & influenza 1,432 12.2 Accidents 1,360 11.6 - Pneumonia & influenza - Homicide 11 ( 0.3) Meningitis 7 (0.2) Cerebrovascular d. 6 (0.2) Pneumonia & influenza 7 ( 0.4) - Congenital conditions - Poisoning undetermined intent 17 ( 0.5) Diabetes 16 (0.5) Chronic liver disease 15 ( 0.5) Kidney disease 13 (0.4) Kidney diseases 117 5.1 CLRD 106 4.5 Suicide 84 3.6 Hypertension 62 2.7 CLRD 207 30.9 Pneumonia & influenza 116 17.3 Accidents 110 16.4 Hypertension 104 15.5 Kidney disease 1,820 276.4 CLRD 1,296 196.8 Pneumonia & influenza 1,248 189.5 Hypertension 1,111 168.7 8 Ministry of health, Israel

Multiple causes of death Multiple causes of death include all causes mentioned on the death certificate. The ranking of multiple causes differs from that of the underlying cause. On average for the years 2010-2012, the leading cause mentioned most frequently on the notification of death form was heart disease, found in 43% of deaths. Cancer was 2 nd, in 28% of deaths, and septicemia was the 3 rd most frequent, mentioned in 27% of deaths. The 4 th cause was kidney disease for males (mentioned in 20% of their deaths) and hypertension for females (23% of deaths), which was the 5 th cause for males. Diabetes was 5 th in females and 6 th in males, and cerebrovascular disease was 7 th for both genders. Comparison of leading underlying and multiple causes 2009-2011, rate per 100,000 population Rank Underlying cause Total Males Females Multiple causes Underlying cause Multiple causes Underlying cause Multiple causes 1 Malignant 134.4 2 86.5 223.1 Malignant 148.0 Malignant 137.0 87.5 224.9 Malignant 151.8 Malignant 131.7 85.4 221.3 Malignant 146.5 3 Cerebrovascular d. 31.0 142.9 Cerebrovascular d. 28.1 139.1 Cerebrovascular d. 33.8 144.2 4 Diabetes 29.0 Hypertension 103.9 Diabetes 27.0 Kidney disease 103.8 Diabetes 31.0 Hypertension 119.1 5 Kidney disease 20.2 Kidney disease 94.5 Kidney disease 21. 8 Hypertension 88.3 Kidney disease 20.1 Diabetes 85.4 6 19.0 Diabetes 81.2 17.8 Diabetes 77.9 18.6 Kidney disease 84.4 7 CLRD 15. 5 8 Accidents 14.6 9 Dementia 13.7 10 Pneumonia & influenza 11.8 Cerebrovascular d. 70.9 Pneumonia & influenza 63.8 Dementia 50.7 CLRD 36.8 Accidents 17.8 CLRD 17.2 Pneumonia & influenza 11.4 Suicide 9.3 Cerebrovascular d. 67.5 Pneumonia & influenza 65.4 CLRD 42.9 Dementia 36.9 Dementia 17.8 CLRD 13.9 Pneumonia & influenza 12.2 Accidents 11.6 Cerebrovascular d. 74.3 Dementia 64.2 Pneumonia & influenza 62.3 Anemias 36.0 Leading causes of death in Israel, 2000-2012 9

Tables: Leading causes of death by year Tables: leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population All ages - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 617.5 564.6 547.1 558.1 539.4 516.7 520.7 522.2 528.2 1 Malignant 143.5 139.1 136.4 138.5 137.3 134.4 137.9 135.4 137.8 2 136.5 107.4 101.8 109.6 97.3 91.3 91.4 88.4 82.9 3 Cerebrovascular disease 38.7 34.6 31.9 31.2 25.3 25.0 26.7 28.4 29.2 4 Diabetes 34.1 32.9 31.2 32.0 30.1 29.3 28.3 26.5 26.3 5 Kidney disease 20.7 27.6 28.7 22.3 21.1 21.3 21.4 20.6 23.3 6 11.3 10.8 12.4 11.2 13.6 13.3 14.2 18.8 20.3 7 CLRD 22.4 17.8 17.3 17.8 15.4 16.1 17.0 17.3 17.3 8 Accidents 28.2 22.6 21.4 21.1 22.3 18.2 18.8 18.9 15.6 9 Flu/pneumonia 11.5 11.2 10.4 13.6 13.8 12.5 9.9 11.6 12.7 10 Dementia 4.7 2.9 2.2 3.4 7.9 7.6 9.5 9.5 9.6 11 Suicide 9.9 8.9 8.0 7.4 8.1 8.4 10.4 8.4 8.9 12 Hypertension 7.2 5.8 6.0 6.8 7.6 5.6 6.4 7.2 6.9 13 Pnemonitis due to solids and liquids 4.4 5.4 5.6 5.9 5.8 4.9 5.1 5.9 5.7 14 Alzheimer s disease 3.0 3.9 3.3 3.3 4.0 3.7 4.6 4.7 4.4 15 Liver disease 5.1 4.1 4.7 4.3 4.0 4.5 3.7 4.1 4.2 16 Congenital conditions 4.1 4.4 4.0 4.2 4.5 4.2 3.4 3.7 3.9 17 Perinatal conditions 6.6 4.4 4.2 4.2 4.1 4.0 4.2 3.4 3.7 18 Other causes 125.6 121.1 117.6 121.4 117.2 112.3 107.5 109.5 115.5 Absolute number Total 19,158 19,328 19,069 19,808 19,495 19,123 19,636 20,059 20,686 1 Malignant 4,451 4,762 4,754 4,915 4,963 4,974 5,201 5,201 5,398 2 4,234 3,675 3,549 3,889 3,515 3,381 3,447 3,397 3,245 3 Cerebrovascular disease 1,202 1,184 1,111 1,109 916 924 1,006 1,089 1,143 4 Diabetes 1,057 1,127 1,086 1,134 1,088 1,085 1,067 1,016 1,029 5 Kidney disease 643 946 1,000 790 761 788 806 792 911 6 350 370 433 397 493 494 536 721 796 7 CLRD 694 609 604 633 556 596 641 665 676 8 Accidents 876 772 747 748 806 672 709 727 612 9 Flu/pneumonia 356 382 363 482 500 463 375 445 496 10 Dementia 147 99 77 120 284 281 358 363 375 11 Suicide 307 304 279 263 294 310 394 322 349 12 Hypertension 223 199 208 240 275 208 243 275 272 13 Pnemonitis due to solids and liquids 136 184 195 211 210 182 194 225 222 14 Alzheimer s disease 92 132 116 118 145 137 173 180 174 15 Liver disease 159 139 164 153 145 168 141 159 166 16 Congenital conditions 128 150 139 150 163 155 130 144 153 17 Perinatal conditions 206 150 145 148 147 149 159 132 145 18 Other causes 3,897 4,144 4,099 4,308 4,234 4,156 4,056 4,206 4,524 10 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population All ages - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 581.4 558.0 546.3 554.7 534.4 514.5 513.5 525.1 530.5 1 Malignant 138.9 136.2 136.5 135.6 135.9 130.8 134.4 129.6 131.2 2 124.4 108.2 102.5 104.8 96.4 90.1 86.1 88.1 82.1 3 Cerebrovascular disease 45.4 42.1 39.1 38.9 30.5 31.9 33.1 34.5 33.8 4 Diabetes 41.5 36.8 36.4 36.1 36.9 34.2 31.5 29.9 31.5 5 13.3 13.5 15.4 15.8 15.5 14.7 16.4 20.6 23.3 6 Dementia 7.7 5.5 5.1 8.1 14.2 14.0 16.8 17.6 18.9 7 Kidney disease 16.7 21.9 24.9 20.5 17.2 19.6 17.6 19.2 18.9 8 CLRD 19.0 16.8 15.9 16.0 13.7 12.2 12.8 14.7 14.1 9 Flu/pneumonia 11.5 13.1 11.0 14.0 13.4 13.0 12.3 12.1 12.1 10 Accidents 13.2 13.8 13.0 12.9 13.2 12.3 11.8 11.4 11.5 11 Hypertension 10.9 10.1 10.6 11.0 11.7 10.1 10.4 11.5 10.7 12 Alzheimer s disease 4.9 6.4 6.8 6.4 7.2 8.0 8.0 8.8 9.3 13 Pnemonitis due to solids and liquids 5.2 5.7 7.0 6.3 7.0 5.6 5.9 6.7 7.2 14 Congenital conditions 3.0 3.6 2.9 3.6 2.9 3.5 3.2 3.6 3.5 15 Benign/other 4.7 4.0 3.3 4.0 4.4 4.1 4.3 3.9 3.4 16 Anemias 3.9 2.5 2.4 2.9 3.4 3.6 2.8 3.0 2.9 17 Parkinson s disease 4.0 3.9 3.0 3.4 2.7 2.6 3.2 3.0 2.8 18 Other causes 113.1 113.9 110.5 114.2 108.0 104.2 102.8 106.9 113.1 Absolute number Total 18,527 19,568 19,492 20,139 19,746 19,471 19,779 20,609 21,189 1 Malignant 4,427 4,775 4,871 4,924 5,020 4,949 5,179 5,087 5,242 2 3,964 3,793 3,658 3,806 3,563 3,410 3,316 3,459 3,280 3 Cerebrovascular disease 1,448 1,476 1,396 1,414 1,128 1,209 1,274 1,353 1,350 4 Diabetes 1,322 1,292 1,300 1,310 1,365 1,294 1,213 1,174 1,258 5 424 473 551 575 574 558 630 808 930 6 Dementia 246 192 181 294 526 531 649 690 756 7 Kidney disease 532 767 888 746 636 741 677 755 754 8 CLRD 605 589 568 581 507 462 493 575 564 9 Flu/pneumonia 366 458 394 510 496 492 475 474 483 10 Accidents 422 484 463 467 486 464 454 446 460 11 Hypertension 348 354 378 400 433 382 400 452 429 12 Alzheimer s disease 157 225 241 233 267 302 309 345 372 13 Pnemonitis due to solids and liquids 166 200 251 227 260 211 228 264 289 14 Congenital conditions 96 127 103 131 107 131 124 143 140 15 Benign/other 151 141 116 144 163 155 164 154 137 16 Anemias 123 89 84 106 126 138 108 118 115 17 Parkinson s disease 127 137 107 124 99 100 125 116 112 18 Other causes 3,603 3,996 3,942 4,147 3,990 3,942 3,961 4,196 4,518 Leading causes of death in Israel, 2000-2012 11

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 1-74 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 304.2 264.6 254.5 255.7 244.4 233.0 233.7 231.7 230.8 1 Malignant 86.0 77.2 77.7 77.4 76.9 75.0 77.9 75.2 76.9 2 56.6 39.2 36.9 39.2 34.7 31.0 31.1 30.2 29.0 3 Diabetes 16.7 14.5 12.9 14.1 12.7 12.3 11.8 11.3 10.4 4 Accidents 22.7 17.2 16.1 15.9 16.0 12.3 12.5 13.2 10.1 5 Cerebrovascular disease 14.3 12.2 11.0 11.4 8.6 8.7 8.7 9.3 9.6 6 Suicide 9.2 8.3 7.8 7.0 7.4 8.2 10.0 7.7 8.6 7 Kidney disease 7.5 8.7 7.5 5.8 5.7 5.9 5.8 6.2 6.2 8 3.8 3.4 3.8 3.2 4.2 4.4 4.2 5.4 5.8 9 CLRD 9.0 6.9 6.6 6.6 5.7 6.0 6.2 6.4 5.1 10 Flu/pneumonia 3.4 3.1 3.0 3.3 3.4 3.8 2.8 3.2 3.1 11 Liver disease 3.8 3.0 3.4 3.3 2.5 3.1 2.6 3.0 2.9 12 Homicide 3.9 3.7 3.4 3.2 2.6 3.2 3.2 3.1 2.7 13 Hypertension 2.8 2.1 2.0 2.3 2.4 1.6 2.1 2.1 2.3 14 Congenital conditions 1.1 1.0 1.2 1.2 1.3 1.1 0.9 0.9 1.3 15 Psychoactive substance abuse 2.3 2.0 1.8 1.6 1.6 1.5 1.3 1.4 1.2 16 Benign/other 1.7 1.2 1.2 1.6 1.4 1.4 1.5 1.1 1.1 17 Poisoning, undetermined intent 3.1 3.8 2.4 3.4 2.3 2.2 1.4 1.1 1.0 18 Other causes 56.2 57.0 55.6 55.2 55.1 51.3 49.7 50.9 53.4 Absolute number Total 8,892 8,527 8,351 8,540 8,309 8,108 8,280 8,355 8,483 1 Malignant 2,513 2,487 2,550 2,585 2,616 2,609 2,761 2,712 2,825 2 1,655 1,262 1,212 1,310 1,179 1,078 1,101 1,088 1,065 3 Diabetes 488 468 424 470 431 429 419 409 383 4 Accidents 664 555 527 530 545 429 442 475 372 5 Cerebrovascular disease 418 393 362 380 291 302 308 335 353 6 Suicide 268 269 257 234 251 287 354 278 316 7 Kidney disease 218 280 245 195 194 206 205 223 227 8 111 110 126 106 143 152 150 194 215 9 CLRD 264 222 218 220 193 208 219 229 189 10 Flu/pneumonia 100 99 97 111 116 131 98 114 114 11 Liver disease 112 96 113 109 86 109 93 109 107 12 Homicide 113 118 110 106 87 113 113 111 101 13 Hypertension 83 69 67 78 82 57 75 76 84 14 Congenital conditions 32 33 40 41 43 40 31 33 47 15 Psychoactive substance abuse 68 66 58 55 53 51 47 52 43 16 Benign/other 51 38 41 52 47 48 54 41 40 17 Poisoning, undetermined intent 91 124 80 113 77 75 48 40 38 18 Other causes 1,643 1,838 1,824 1,845 1,875 1,784 1,762 1,836 1,964 12 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 1-74 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 206.8 174.0 169.5 166.4 160.1 154.4 151.4 152.1 148.8 1 Malignant 82.6 75.4 73.2 73.8 73.8 71.4 73.2 69.3 70.3 2 30.6 19.3 18.6 17.0 16.4 14.8 12.7 12.7 11.6 3 Diabetes 15.7 10.9 10.7 10.0 9.9 8.9 8.1 7.3 7.4 4 Cerebrovascular disease 11.0 7.8 7.7 7.0 5.8 5.5 5.8 6.2 5.3 5 Accidents 6.3 5.8 5.7 5.0 4.5 4.5 4.6 3.7 4.3 6 3.3 2.4 2.7 3.1 3.2 2.3 2.5 3.6 4.1 7 Kidney disease 5.6 4.9 6.2 4.7 3.8 4.2 3.1 3.8 3.2 8 CLRD 5.4 3.8 3.4 3.4 2.9 2.8 3.1 3.1 3.0 9 Suicide 2.5 3.0 2.3 1.7 1.4 2.5 2.2 2.2 2.0 10 Liver disease 2.1 1.3 1.3 1.4 1.1 1.5 1.2 1.7 1.4 11 Flu/pneumonia 2.2 2.0 1.4 1.7 1.7 2.0 1.9 1.8 1.3 12 Hypertension 2.1 1.2 1.6 1.3 1.7 1.3 1.7 1.8 1.2 13 Benign/other 1.7 1.0 0.7 1.1 1.2 1.2 1.0 1.5 0.8 14 Congenital conditions 0.7 1.0 1.0 0.8 0.9 1.1 1.0 1.4 0.8 15 Dementia (0.5) (0.3) (0.2) (0.5) 0.7 (0.3) 0.7 0.8 0.8 16 Viral hepatitis 0.8 1.1 1.1 0.7 0.8 0.7 (0.5) 0.7 0.6 17 Alzheimer s disease (0.6) (0.6) (0.5) (0.6) (0.5) (0.4) (0.3) (0.5) 0.6 18 Other causes 33.0 32.1 31.3 32.7 29.6 29.0 27.9 30.1 30.0 Absolute number Total 6,126 5,652 5,602 5,592 5,472 5,400 5,390 5,513 5,486 1 Malignant 2,447 2,450 2,419 2,479 2,523 2,499 2,604 2,512 2,593 2 905 627 613 571 560 518 451 459 427 3 Diabetes 466 354 354 337 337 311 287 263 274 4 Cerebrovascular disease 326 253 255 234 199 191 208 223 194 5 Accidents 188 190 187 167 153 159 164 135 157 6 99 79 90 103 110 80 89 129 153 7 Kidney disease 165 158 204 157 131 146 112 136 117 8 CLRD 160 122 113 115 98 99 111 113 112 9 Suicide 74 98 75 56 49 86 77 80 72 10 Liver disease 63 43 42 48 37 51 43 63 50 11 Flu/pneumonia 64 65 45 58 59 71 66 65 48 12 Hypertension 61 39 52 45 59 47 61 65 44 13 Benign/other 50 34 24 37 42 41 36 55 31 14 Congenital conditions 21 32 34 26 32 37 35 52 31 15 Dementia 16 11 7 16 24 12 25 29 31 16 Viral hepatitis 24 35 35 25 28 26 18 24 23 17 Alzheimer s disease 19 18 18 19 18 13 10 18 21 18 Other causes 978 1,044 1,035 1,099 1,013 1,013 993 1,092 1,108 Leading causes of death in Israel, 2000-2012 13

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 0-4 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 157.7 120.4 121.5 107.2 113.6 103.8 99.4 94.6 96.5 1 Perinatal conditions 62.1 41.2 39.3 39.5 38.6 38.6 40.1 32.4 34.7 2 Congenital conditions 29.8 34.9 29.3 31.5 34.4 32.9 26.5 27.5 28.3 3 Accidents 8.7 8.5 8.7 6.9 6.6 (3.1) 5.5 (4.7) 6.5 4 Flu/pneumonia.. (1.4)...... (1.3).... (2.2) 5 Malignant (3.9) (2.2) (3.5) (2.7) (3.9) (1.8) (3.5) (2.9) (1.7) 6 6.3 (1.6) (2.4).. (1.8) (2.1) (2.0) (1.2) (1.2) 7 Meningitis................ 8 Other causes 45.3 30.2 36.1 24.5 27.0 23.8 20.9 24.8 21.1 Absolute number Total 523 438 448 402 433 401 394 385 403 1 Perinatal conditions 206 150 145 148 147 149 159 132 145 2 Congenital conditions 99 127 108 118 131 127 105 112 118 3 Accidents 29 31 32 26 25 12 22 19 27 4 Flu/pneumonia 3 5 4 3 3 5 3 2 9 5 Malignant 13 8 13 10 15 7 14 12 7 6 21 6 9 4 7 8 8 5 5 7 Meningitis 1 1 4 1 2 1 2 4 8 Other causes 151 111 133 92 103 92 83 101 88 14 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 0-4 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 121.9 101.3 93.9 94.9 88.1 92.6 89.6 87.2 83.5 1 Congenital conditions 24.2 28.1 21.4 28.9 22.1 28.3 25.5 28.4 27.7 2 Perinatal conditions 46.2 37.0 30.0 31.7 30.7 39.5 35.3 28.4 27.2 3 Accidents (5.1) (4.1) 6.6 (4.8) (4.4) (2.5) (5.0) (3.9) (4.3) 4 Malignant (2.2) (2.0).. (2.2) (1.7) (2.5) (1.3) (2.3) (1.5) 5 (4.8).. (3.4) (2.0) (1.4).. (1.9) (1.5).. 6 Homicide.................. 7 (1.9) (1.4).......... (1.5).. 8 Other causes 36.3 27.5 30.5 24.4 26.8 18.5 19.1 20.6 20.9 Absolute number Total 383 350 329 338 319 340 338 338 332 1 Congenital conditions 76 97 75 103 80 104 96 110 110 2 Perinatal conditions 145 128 105 113 111 145 133 110 108 3 Accidents 16 14 23 17 16 9 19 15 17 4 Malignant 7 7 2 8 6 9 5 9 6 5 15 3 12 7 5 2 7 6 3 6 Homicide 4 1 1 3 2 3 2 3 7 6 5 4 3 1 1 3 6 2 8 Other causes 114 95 107 87 97 68 72 80 83 Leading causes of death in Israel, 2000-2012 15

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 5-14 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 15.9 13.1 16.1 14.3 14.4 13.3 13.1 13.5 11.6 1 Accidents 5.4 3.7 5.5 3.6 3.8 (2.2) 3.4 2.9 4.0 2 Malignant (3.0) (2.6) 3.0 3.4 3.1 (2.8) (2.3) 3.5 (1.8) 3 Congenital conditions (0.8) (1.1) (0.7) (0.9) (0.7) (1.1) (1.3) (1.1) 4.... (0.8).. (0.7).. (0.7).... 5 Suicide................ 6 Homicide.... (0.7).... 7 Other causes 5.9 6.1 5.6 5.7 5.6 6.4 4.4 4.9 3.5 Absolute number Total 94 84 106 96 98 91 91 96 84 1 Accidents 32 24 36 24 26 15 24 21 29 2 Malignant 18 17 20 23 21 19 16 25 13 3 Congenital conditions 5 7 5 6 5 8 9 8 4 2 2 5 3 5 4 5 3 3 5 Suicide 1 2 3 2 4 2 1 3 6 Homicide 1 1 5 2 3 7 Other causes 35 39 37 38 38 44 31 35 25 16 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 5-14 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 12.3 9.5 11.1 11.8 10.5 11.2 9.4 8.4 7.7 1 Malignant (2.0) (2.6) (2.7) 3.1 (2.9) (2.0) (2.0) (2.7) (1.9) 2 Congenital conditions........ (0.9) (1.1).... (1.3) 3 Accidents (3.0) (1.6) (1.9) (1.6) (0.8) (1.8) (1.7).. (1.3) 4.................. 5...... 6 Flu/pneumonia.................. 7 Other causes 5.9 4.4 5.1 5.7 4.9 5.4 4.4 3.6 2.5 Absolute number Total 69 58 69 75 68 73 62 57 53 1 Malignant 11 16 17 20 19 13 13 18 13 2 Congenital conditions 2 2 3 4 6 7 4 4 9 3 Accidents 17 10 12 10 5 12 11 4 9 4 4 2 4 4 4 4 4 4 3 5 1 2 1 6 Flu/pneumonia 1 1 1 1 2 2 1 1 1 7 Other causes 33 27 32 36 32 35 29 24 17 Leading causes of death in Israel, 2000-2012 17

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 15-24 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 76.2 60.6 57.2 58.0 60.9 50.7 47.4 43.9 38.4 1 Accidents 30.2 20.8 20.6 21.3 19.2 15.4 14.5 16.0 11.1 2 Suicide 11.8 11.5 10.5 7.7 11.0 8.0 10.5 6.8 5.2 3 Homicide 5.8 5.9 4.8 5.3 4.0 6.4 4.0 5.1 5.0 4 Malignant 5.4 3.5 (3.1) 5.3 6.6 4.9 5.3 3.5 4.4 5 (1.6) (1.9) (1.2) (2.0) (1.9) (2.2) (1.5) (0.8) (1.5) 6 War/terror 4.5 (2.6) (2.6) (1.0) (2.7) (1.3).... (0.8) 7 Congenital conditions.... (1.0) (1.0).......... 8.................. 9 Other causes 15.8 13.5 13.2 14.3 14.2 11.9 10.7 10.4 9.3 Absolute number Total 421 349 333 341 361 303 285 266 236 1 Accidents 167 120 120 125 114 92 87 97 68 2 Suicide 65 66 61 45 65 48 63 41 32 3 Homicide 32 34 28 31 24 38 24 31 31 4 Malignant 30 20 18 31 39 29 32 21 27 5 9 11 7 12 11 13 9 5 9 6 War/terror 25 15 15 6 16 8 3 2 5 7 Congenital conditions 4 4 6 6 4 2 1 4 4 8 2 1 1 1 4 2 2 2 3 9 Other causes 87 78 77 84 84 71 64 63 57 18 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 15-24 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Total Rate per 100,000 population 1 Accidents 22.6 23.5 22.2 19.1 14.4 17.8 15.9 13.9 17.5 2 Malignant 6.0 5.4 5.9 (3.2) (2.5) (2.6) 3.6 (2.2) 3.6 3 Suicide 4.7 4.3 (2.7) 4.1 (3.3) 3.5 (2.8) (3.1) (2.5) 4 (1.9) (2.3) (3.2) 1.8 (1.2) (2.3) (1.7) (2.1) (2.2) 5 Congenital conditions (1.9) (1.1) (1.3).. (1.2) (1.0).... (1.2) 6 Flu/pneumonia........ (0.9) (0.9).... (0.8) 7 Kidney disease.. (1.0)...... 8 Homicide...... 9 Other causes 6.0 6.5 7.2 8.2 4.9 5.2 6.1 4.8 5.9 Absolute number Total 120 130 124 108 82 102 92 81 103 1 Accidents 32 30 33 18 14 15 21 13 21 2 Malignant 25 24 15 23 19 20 16 18 15 3 Suicide 10 13 18 10 7 13 10 12 13 4 10 6 7 3 7 6 4 1 7 5 Congenital conditions 2 4 3 2 5 5 1 4 5 6 Flu/pneumonia 1 6 3 1 3 7 Kidney disease 1 2 2 8 Homicide 7 15 8 6 2 7 2 4 2 9 Other causes 32 36 40 46 28 30 35 28 35 Leading causes of death in Israel, 2000-2012 19

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 25-44 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 130.8 103.0 96.3 93.4 90.2 84.9 91.5 75.0 73.8 1 Malignant 18.9 14.1 15.0 13.3 15.2 12.1 15.9 13.3 16.0 2 Suicide 14.1 10.2 10.0 10.6 8.4 11.7 12.9 9.1 11.6 3 Accidents 29.7 19.4 16.1 14.5 14.8 11.5 13.4 13.3 7.4 4 11.8 6.8 5.7 7.8 8.9 6.1 7.2 4.3 5.1 5 Homicide 7.0 6.2 5.5 4.0 3.9 3.9 6.1 4.6 4.4 6 Poisoning, undetermined intent 6.8 7.0 4.0 6.7 4.1 4.3 2.9 (1.7) (1.8) 7 Cerebrovascular disease (1.8) 2.2 (1.3) (1.1) (1.5) (1.0) (1.1) (1.0) (1.2) 8 Aids (1.0) (0.8) (0.6) (1.8).. (1.1).. (0.8) (0.8) 9 Liver disease (1.7) (1.2) (1.2) (0.9) (1.0) (1.5) (1.2) (0.7) (0.8) 10 Congenital conditions (1.1) (0.8).. (0.7) (1.1) (0.8) (0.7).. (0.8) 11 Psychoactive substance abuse (2.3) (2.0) (1.9) (1.3) (1.4) (1.3) (1.1) (1.2) (0.7) 12 Viral hepatitis (1.3) (1.1) (0.7)........ (0.6) (0.6) 13.. (1.1) (1.0) (0.6) (0.6) (0.7) (0.5) (0.8) (0.5) 14 Diabetes (1.0) (1.2) (1.2) (1.3) (0.9) (1.3) (1.4) (0.7) (0.5) 15 Flu/pneumonia (1.7) (1.0) (0.6) (1.1) (0.7) (1.6) (0.7) (1.1).. 16 CLRD (1.2).. (1.0).. (0.5).. (0.7) (0.5).. 17 Kidney disease (1.0) (1.0) (0.8) (0.7) (1.0) (1.1) (0.7) (0.7).. 18 Other causes 28.2 26.8 29.6 25.9 25.4 24.2 24.8 20.5 20.8 Absolute number Total 1,085 957 911 900 888 863 946 785 789 1 Malignant 157 131 142 128 150 123 164 139 171 2 Suicide 117 95 95 102 83 119 133 95 124 3 Accidents 246 180 152 140 146 117 139 139 79 4 98 63 54 75 88 62 74 45 55 5 Homicide 58 58 52 39 38 40 63 48 47 6 Poisoning, undetermined intent 56 65 38 65 40 44 30 18 19 7 Cerebrovascular disease 15 20 12 11 15 10 11 10 13 8 Aids 8 7 6 17 3 11 4 8 9 9 Liver disease 14 11 11 9 10 15 12 7 9 10 Congenital conditions 9 7 1 7 11 8 7 4 9 11 Psychoactive substance abuse 19 19 18 13 14 13 11 13 7 12 Viral hepatitis 11 10 7 4 3 4 2 6 6 13 3 10 9 6 6 7 5 8 5 14 Diabetes 8 11 11 13 9 13 14 7 5 15 Flu/pneumonia 14 9 6 11 7 16 7 12 3 16 CLRD 10 3 9 3 5 4 7 5 3 17 Kidney disease 8 9 8 7 10 11 7 7 3 18 Other causes 234 249 280 250 250 246 256 214 222 20 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 25-44 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 55.1 49.4 51.9 45.8 41.7 43.3 42.2 43.3 41.1 1 Malignant 26.9 20.7 22.0 20.8 20.8 19.7 20.0 19.3 20.4 2 Accidents 5.3 4.6 4.3 3.5 2.5 3.1 3.8 2.4 3.1 3 Suicide 3.1 3.2 2.7 (1.9) 2.0 3.3 2.1 2.6 2.3 4 3.3 (2.0) 3.8 (1.8) (1.9) (1.8) (1.7) (1.6) (1.7) 5 Homicide (2.1) (1.9) (1.6) (0.8) (1.0) (0.9) (1.4) (1.4) (0.7) 6.... (0.6).. (0.6) (0.7).. (0.9) (0.7) 7 Cerebrovascular disease (1.7) (1.1) (0.8) (0.6) (0.5) (1.4).... (0.6) 8 Aids.. 0.6........ (0.6) (0.5) 9 Liver disease.... (0.6) (0.5)...... (0.7) (0.5) 10 Congenital conditions.. (0.6).......... (0.9).. 11 CLRD (0.6) (0.9) (0.6)........ (0.5).. 12 Poisoning, undetermined intent.... (1.2) (1.3) (0.5).. (0.7) (0.7).. 13 Benign/other.................. 14 Diabetes (0.6).... (1.1) (0.5) (0.5) (0.8) (0.6).. 15 Flu/pneumonia.. (0.8).... (1.0)...... 16 Viral hepatitis................ 17 Psychoactive substance abuse................ 18 Other causes 8.8 11.0 11.4 11.3 9.4 9.5 9.8 9.9 8.8 Absolute number Total 465 461 492 442 410 442 438 456 441 1 Malignant 227 193 209 201 205 201 208 203 219 2 Accidents 45 43 41 34 25 32 39 25 33 3 Suicide 26 30 26 18 20 34 22 27 25 4 28 19 36 17 19 18 18 17 18 5 Homicide 18 18 15 8 10 9 15 15 8 6 3 3 6 4 6 7 3 9 7 7 Cerebrovascular disease 14 10 8 6 5 14 2 4 6 8 Aids 3 6 4 2 2 3 6 5 9 Liver disease 4 2 6 5 3 4 3 7 5 10 Congenital conditions 2 6 4 4 4 2 3 10 4 11 CLRD 5 8 6 3 2 2 1 5 3 12 Poisoning, undetermined intent 4 3 11 13 5 1 7 7 3 13 Benign/other 1 2 2 2 2 2 1 4 2 14 Diabetes 5 4 4 11 5 5 8 6 2 15 Flu/pneumonia 4 7 3 3 10 3 3 2 16 Viral hepatitis 2 2 2 2 1 1 1 2 17 Psychoactive substance abuse 2 1 3 1 1 2 3 2 18 Other causes 74 103 108 109 92 97 102 104 95 Leading causes of death in Israel, 2000-2012 21

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 45-64 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 589.7 538.9 516.0 519.3 510.6 482.1 477.1 502.0 485.8 1 Malignant 189.8 180.7 173.9 173.7 173.9 173.7 176.7 179.1 177.4 2 116.8 82.1 80.9 83.7 75.6 66.1 62.8 66.5 59.6 3 Diabetes 31.7 26.6 24.1 28.1 27.7 26.8 25.2 22.2 21.5 4 Suicide 12.3 13.9 12.1 10.0 12.3 13.5 17.1 15.5 17.3 5 Accidents 24.0 21.9 21.0 22.7 22.3 19.5 14.9 17.6 16.5 6 Cerebrovascular disease 26.3 24.1 18.0 20.9 16.2 16.1 16.0 19.7 16.3 7 Kidney disease 14.5 13.4 14.0 12.1 10.3 9.3 10.2 10.0 12.5 8 7.3 6.2 6.3 5.7 8.2 8.0 8.2 12.3 10.3 9 CLRD 16.0 10.4 11.7 8.9 9.7 10.5 10.2 10.1 8.8 10 Liver disease 10.2 8.1 9.1 8.8 6.6 8.3 6.4 9.3 6.8 11 Flu/pneumonia 5.6 5.3 4.1 4.6 6.1 4.7 4.5 3.8 6.4 12 Hypertension 6.5 4.5 4.4 5.1 6.7 3.0 5.4 4.7 5.4 13 Psychoactive substance abuse 7.3 5.5 4.7 4.8 4.8 4.3 4.0 4.4 4.2 14 Homicide (2.6) 3.7 3.5 4.6 3.1 4.3 2.8 3.7 2.7 15 Benign/other (2.4) (1.9) (3.0) (2.9) (2.4) (2.1) 2.8 (2.6) (2.3) 16 Viral hepatitis 5.4 7.0 4.4 (2.8) 4.5 (2.1) 3.1 3.0 (2.3) 17 Poisoning, undetermined intent (3.0) 5.5 4.1 4.5 3.3 3.3 (1.7) (1.6) (2.3) 18 Other causes 107.9 118.0 116.7 115.5 116.9 106.6 105.1 115.7 113.1 Absolute number Total 3,165 3,328 3,273 3,381 3,412 3,384 3,424 3,661 3,573 1 Malignant 1,019 1,116 1,103 1,131 1,162 1,219 1,268 1,306 1,305 2 627 507 513 545 505 464 451 485 438 3 Diabetes 170 164 153 183 185 188 181 162 158 4 Suicide 66 86 77 65 82 95 123 113 127 5 Accidents 129 135 133 148 149 137 107 128 121 6 Cerebrovascular disease 141 149 114 136 108 113 115 144 120 7 Kidney disease 78 83 89 79 69 65 73 73 92 8 39 38 40 37 55 56 59 90 76 9 CLRD 86 64 74 58 65 74 73 74 65 10 Liver disease 55 50 58 57 44 58 46 68 50 11 Flu/pneumonia 30 33 26 30 41 33 32 28 47 12 Hypertension 35 28 28 33 45 21 39 34 40 13 Psychoactive substance abuse 39 34 30 31 32 30 29 32 31 14 Homicide 14 23 22 30 21 30 20 27 20 15 Benign/other 13 12 19 19 16 15 20 19 17 16 Viral hepatitis 29 43 28 18 30 15 22 22 17 17 Poisoning, undetermined intent 16 34 26 29 22 23 12 12 17 18 Other causes 579 729 740 752 781 748 754 844 832 22 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 45-64 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 349.5 310.4 289.8 305.1 302.4 294.0 285.3 293.3 273.3 1 Malignant 183.1 170.7 162.6 172.5 167.1 167.5 165.1 160.5 150.4 2 40.2 23.4 22.7 20.4 24.1 19.8 16.6 19.7 16.9 3 Diabetes 21.2 14.9 12.8 15.9 14.3 13.4 10.3 11.2 11.6 4 Cerebrovascular disease 14.2 10.9 10.6 7.6 9.1 7.7 8.6 10.7 7.8 5 CLRD 6.9 5.2 5.8 5.4 3.9 4.5 5.1 4.0 6.0 6 4.5 3.3 2.9 3.1 5.9 3.8 4.7 5.1 5.5 7 Kidney disease 7.7 6.7 7.3 6.7 5.8 6.4 4.8 4.1 4.7 8 Accidents 6.5 6.4 5.1 6.7 6.2 6.2 5.8 6.4 4.6 9 Suicide 3.9 6.6 3.6 2.8 (1.5) 4.2 3.6 4.2 2.9 10 Liver disease 3.8 (2.1) (1.9) (2.5) (1.9) 2.9 (2.3) 2.6 (2.4) 11 Hypertension (2.6) (1.6) (2.5) (1.3) (2.1) (1.9) 2.7 3.3 (1.9) 12 Benign/other (2.4) (1.9) (1.3) (2.0) (2.3) (2.1) (2.1) 2.7 (1.5) 13 Flu/pneumonia (2.1) (1.9) (1.3) (1.6) 2.8 2.7 (2.1) (2.0) (1.3) מפרצת באב העורקים 14 (1.0)........ (0.7).. (0.9) (1.0) 15 Homicide (0.9) (1.5) (0.7).. (1.1) (1.2).. (1.3) (0.9) 16 Viral hepatitis (1.4) (1.6) (1.6) (1.4) (1.8) (1.6) (1.3) (1.0) (0.9) 17 Congenital conditions.. (1.3) (1.5) (1.1) (1.0).. (1.8) (1.2) (0.8) 18 Other causes 46.8 49.9 45.4 53.0 51.0 47.2 47.4 52.4 52.4 Absolute number Total 2,041 2,079 1,993 2,154 2,192 2,217 2,197 2,295 2,150 1 Malignant 1,069 1,143 1,118 1,218 1,211 1,263 1,271 1,256 1,183 2 235 157 156 144 175 149 128 154 133 3 Diabetes 124 100 88 112 104 101 79 88 91 4 Cerebrovascular disease 83 73 73 54 66 58 66 84 61 5 CLRD 40 35 40 38 28 34 39 31 47 6 26 22 20 22 43 29 36 40 43 7 Kidney disease 45 45 50 47 42 48 37 32 37 8 Accidents 38 43 35 47 45 47 45 50 36 9 Suicide 23 44 25 20 11 32 28 33 23 10 Liver disease 22 14 13 18 14 22 18 20 19 11 Hypertension 15 11 17 9 15 14 21 26 15 12 Benign/other 14 13 9 14 17 16 16 21 12 13 Flu/pneumonia 12 13 9 11 20 20 16 16 10 מפרצת באב העורקים 14 6 2 2 4 3 5 4 7 8 15 Homicide 5 10 5 4 8 9 4 10 7 16 Viral hepatitis 8 11 11 10 13 12 10 8 7 17 Congenital conditions 3 9 10 8 7 2 14 9 6 18 Other causes 273 334 312 374 370 356 365 410 412 Leading causes of death in Israel, 2000-2012 23

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 65-74 - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 2669.3 2228.0 2148.5 2206.6 2037.6 1940.7 1923.5 1839.1 1858.1 1 Malignant 847.0 718.1 745.2 746.2 723.5 691.6 703.4 640.1 648.9 2 604.6 404.9 374.1 396.7 332.4 303.3 309.9 289.7 277.4 3 Diabetes 204.8 175.8 153.8 161.2 139.4 129.4 123.6 126.6 109.6 4 Cerebrovascular disease 170.5 130.8 135.4 135.2 97.6 99.8 98.7 95.5 108.6 5 Kidney disease 85.9 111.0 87.9 63.8 67.1 73.0 68.7 74.4 65.7 6 42.9 36.0 43.3 36.0 42.9 47.9 44.9 48.0 65.2 7 CLRD 111.0 91.8 77.2 93.3 70.6 73.0 76.5 78.6 59.8 8 Flu/pneumonia 33.7 27.0 37.4 38.4 37.1 42.2 28.3 36.9 29.9 9 Accidents 45.6 44.4 35.6 41.9 54.7 33.1 39.9 38.0 27.9 10 Liver disease 28.4 21.0 26.1 25.4 18.8 20.5 19.4 17.9 23.9 11 Hypertension 29.1 22.2 21.4 26.0 18.8 18.2 18.8 19.0 20.9 12 Suicide (12.6) 12.0 14.3 (11.2) (11.2) 12.0 18.3 14.8 14.9 13 Pnemonitis due to solids and liquids (12.6) 18.6 14.3 13.6 12.9 15.4 13.3 (7.9) 14.4 14 Dementia (11.9) (4.2) (4.2) (5.9) (9.4) (8.6) 16.6 16.4 14.4 15 Benign/other 17.8 13.2 (11.3) 17.1 12.4 14.3 15.0 (10.0) 10.0 מפרצת באב העורקים 16 (8.6) (10.8) 12.5 (9.4) (8.2) 14.3 13.9 (8.4) (9.0) 17 Parkinson s disease (9.3) (9.6) 14.3 (10.6) (10.0) (10.3) (8.9) (4.7) (8.0) 18 Other causes 393.1 376.7 340.3 374.9 370.6 334.1 305.4 311.9 349.6 Absolute number Total 4,040 3,714 3,618 3,738 3,464 3,404 3,470 3,485 3,731 1 Malignant 1,282 1,197 1,255 1,264 1,230 1,213 1,269 1,213 1,303 2 915 675 630 672 565 532 559 549 557 3 Diabetes 310 293 259 273 237 227 223 240 220 4 Cerebrovascular disease 258 218 228 229 166 175 178 181 218 5 Kidney disease 130 185 148 108 114 128 124 141 132 6 65 60 73 61 73 84 81 91 131 7 CLRD 168 153 130 158 120 128 138 149 120 8 Flu/pneumonia 51 45 63 65 63 74 51 70 60 9 Accidents 69 74 60 71 93 58 72 72 56 10 Liver disease 43 35 44 43 32 36 35 34 48 11 Hypertension 44 37 36 44 32 32 34 36 42 12 Suicide 19 20 24 19 19 21 33 28 30 13 Pnemonitis due to solids and liquids 19 31 24 23 22 27 24 15 29 14 Dementia 18 7 7 10 16 15 30 31 29 15 Benign/other 27 22 19 29 21 25 27 19 20 מפרצת באב העורקים 16 13 18 21 16 14 25 25 16 18 17 Parkinson s disease 14 16 24 18 17 18 16 9 16 18 Other causes 595 628 573 635 630 586 551 591 702 24 Ministry of Health, Israel

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 65-74 - Females Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 1734.4 1392.1 1380.3 1330.9 1289.7 1199.6 1195.3 1145.5 1145.6 1 Malignant 572.6 519.7 512.6 488.9 517.3 475.3 512.2 452.6 494.0 2 323.0 214.8 196.2 193.8 172.1 162.8 137.6 125.3 113.2 3 Diabetes 174.2 121.8 126.9 103.7 110.4 98.1 93.9 75.9 77.3 4 Cerebrovascular disease 117.3 82.3 82.8 83.8 61.7 57.0 65.3 58.4 54.2 5 34.6 25.8 30.5 35.9 29.7 21.1 23.0 33.7 43.1 6 Kidney disease 58.9 50.2 68.8 50.9 40.4 42.1 32.4 43.6 32.9 7 CLRD 58.9 38.0 31.5 33.9 32.6 30.2 33.3 33.7 26.0 8 Accidents 22.7 25.8 22.8 22.3 23.8 21.1 15.0 15.3 18.8 9 Flu/pneumonia 23.3 20.0 15.5 22.3 14.1 15.8 20.2 18.9 13.2 10 Hypertension 23.3 13.2 16.5 16.0 20.4 14.8 16.9 17.5 12.4 11 Liver disease 18.1 13.2 11.1 12.1 (9.2) 12.0 10.3 16.2 11.1 12 Dementia (8.3) (4.9) (3.4) (5.8) 10.7 (4.3) 9.4 11.2 10.7 13 Parkinson s disease (7.2) (7.8) (6.8) (7.3) (2.4) (4.8).. (5.8) 8.5 14 Benign/other 17.1 (9.3) (6.3) (8.7) (9.2) 10.5 (8.0) 12.6 (6.8) 15 Alzheimer s disease (8.3) (6.8) (7.3) (8.7) (7.8) (4.8) (3.3) (7.2) (6.8) 16 Viral hepatitis (7.2) 10.7 10.2 (6.3) (6.8) (6.7) (3.3) (6.7) (6.0) 17 Suicide (7.8) (4.9) (2.4) (3.9) (4.4) (2.9) (6.6) (3.6) (4.7) 18 Other causes 251.7 223.1 228.7 226.7 216.8 215.4 202.8 207.5 205.8 Absolute number Total 3,356 2,858 2,849 2,747 2,653 2,506 2,546 2,551 2,683 1 Malignant 1,108 1,067 1,058 1,009 1,064 993 1,091 1,008 1,157 2 625 441 405 400 354 340 293 279 265 3 Diabetes 337 250 262 214 227 205 200 169 181 4 Cerebrovascular disease 227 169 171 173 127 119 139 130 127 5 67 53 63 74 61 44 49 75 101 6 Kidney disease 114 103 142 105 83 88 69 97 77 7 CLRD 114 78 65 70 67 63 71 75 61 8 Accidents 44 53 47 46 49 44 32 34 44 9 Flu/pneumonia 45 41 32 46 29 33 43 42 31 10 Hypertension 45 27 34 33 42 31 36 39 29 11 Liver disease 35 27 23 25 19 25 22 36 26 12 Dementia 16 10 7 12 22 9 20 25 25 13 Parkinson s disease 14 16 14 15 5 10 4 13 20 14 Benign/other 33 19 13 18 19 22 17 28 16 15 Alzheimer s disease 16 14 15 18 16 10 7 16 16 16 Viral hepatitis 14 22 21 13 14 14 7 15 14 17 Suicide 15 10 5 8 9 6 14 8 11 18 Other causes 487 458 472 468 446 450 432 462 482 Leading causes of death in Israel, 2000-2012 25

Tables: Leading causes of death by year Leading causes of death by underlying cause and year, 2000-2012 Absolute numbers and rates/100,000 population Age 75+ - Males Cause of death 2000 2005 2006 2007 2008 2009 2010 2011 2012 Rate per 100,000 population Total 8892.9 8267.2 8003.1 8264.2 8022.2 7556.3 7572.8 7542.1 7668.0 1 Malignant 1747.8 1796.8 1698.5 1757.0 1736.5 1673.0 1674.5 1646.8 1661.5 2 2317.8 1905.9 1797.2 1945.7 1727.6 1626.3 1607.8 1527.5 1407.0 3 Cerebrovascular disease 709.3 625.3 577.5 550.2 461.9 440.2 478.7 498.3 509.7 4 Kidney disease 380.0 525.7 582.1 449.1 419.7 411.2 412.1 376.4 441.9 5 Diabetes 514.8 520.9 510.4 501.1 486.3 464.3 445.1 402.3 417.3 6 209.9 204.0 233.6 219.6 256.1 242.0 264.4 348.6 374.0 7 CLRD 388.1 305.1 297.6 310.9 268.7 274.6 289.8 288.9 314.6 8 Flu/pneumonia 230.7 222.1 202.8 279.2 283.5 232.8 190.2 218.7 242.9 9 Dementia 115.8 72.7 53.2 83.0 191.7 188.3 220.5 217.4 220.9 10 Accidents 184.6 164.4 165.0 161.5 187.3 170.6 177.2 166.3 149.9 11 Hypertension 126.7 102.8 108.7 122.3 142.9 106.9 115.4 131.9 121.4 12 Pnemonitis due to solids and liquids 94.1 108.3 123.4 129.1 123.6 102.6 109.9 129.2 119.5 13 Alzheimer s disease 66.9 85.4 79.4 80.0 98.4 82.8 105.8 106.7 104.7 14 Parkinson s disease 117.6 96.4 78.6 91.3 91.0 77.1 75.5 70.9 79.5 15 Benign/other 72.4 72.7 60.9 60.4 54.0 77.1 64.6 53.0 52.3 16 Liver disease 42.5 34.0 39.3 33.2 42.9 41.8 33.0 33.1 38.1 17 Anemias 57.9 31.6 30.1 46.0 45.2 44.6 27.5 44.4 34.2 18 Other causes 1516.2 1392.9 1364.7 1444.5 1404.9 1300.1 1280.9 1281.6 1378.6 Absolute number Total 9,830 10,458 10,380 10,950 10,838 10,677 11,026 11,381 11,870 1 Malignant 1,932 2,273 2,203 2,328 2,346 2,364 2,438 2,485 2,572 2 2,562 2,411 2,331 2,578 2,334 2,298 2,341 2,305 2,178 3 Cerebrovascular disease 784 791 749 729 624 622 697 752 789 4 Kidney disease 420 665 755 595 567 581 600 568 684 5 Diabetes 569 659 662 664 657 656 648 607 646 6 232 258 303 291 346 342 385 526 579 7 CLRD 429 386 386 412 363 388 422 436 487 8 Flu/pneumonia 255 281 263 370 383 329 277 330 376 9 Dementia 128 92 69 110 259 266 321 328 342 10 Accidents 204 208 214 214 253 241 258 251 232 11 Hypertension 140 130 141 162 193 151 168 199 188 12 Pnemonitis due to solids and liquids 104 137 160 171 167 145 160 195 185 13 Alzheimer s disease 74 108 103 106 133 117 154 161 162 14 Parkinson s disease 130 122 102 121 123 109 110 107 123 15 Benign/other 80 92 79 80 73 109 94 80 81 16 Liver disease 47 43 51 44 58 59 48 50 59 17 Anemias 64 40 39 61 61 63 40 67 53 18 Other causes 1,676 1,762 1,770 1,914 1,898 1,837 1,865 1,934 2,134 26 Ministry of Health, Israel