Vevo 1100 Product Itemized List

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2014 Vevo 1100 Product Itemized List EDU00496 Rev 1.5

Table of Contents Vevo 1100 Imaging System... 1 Recommended Accessories... 2 Vevo MicroScan transducers... 2 Vevo 1100 Imaging & Analysis Software... 2 Other Accessories... 3 Imaging Stations and Image-Guided Injection Components... 3 Animal Handling Components... 3 Vevo Anesthesia Systems & Accessories - Oxygen + Medical Air... 4

Vevo 1100 Imaging System VS-20033 Vevo 1100 Imaging System with CardioSet This entry level imaging system package is ideal for customers looking to begin preclinical cardiovascular imaging studies. The system package includes: 1) Vevo 1100 high-frequency imaging platform 2) Vevo CardioSet software package for image capture and analysis: (B-Mode, M-Mode, PW Doppler, Color Doppler, LV Analysis) 3) Choice of one (1) MicroScan TM transducer Other features of the package include: a) Instrumentation Hardware - Rolling portable cart and high-frequency ultrasound unit - Available in the following AC voltage configurations: 100 V, 120 V, 230 V - Workflow-driven operator control panel - Vevo Imaging Starter Kit (10907) b) Software - Cineloop image review, capture and display - Advanced Cardiac measurements & annotations - Integrated physiological trace, which includes: display of ECG, respiration waveform and body temperature for adult rodents. (Requires Advanced Physiological Monitoring Unit (11426)) - Data compatible with Vevo Lab offline analysis software c) System Specifications: - Monitor: 24" color display with articulating arm - Network: 100 Mb Ethernet connection - Storage: 750 GB hard drive EDU00526 Vevo 1100 Product Itemized List Rev. 1.5 Page 1

Recommended Accessories Vevo MicroScan transducers 50667 MS201: 9-18 MHz operating frequency MicroScan transducer Used for rat and rabbit cardiovascular (animals > 500 g); 11957 MS250: 13-24 MHz operating frequency MicroScan transducer Used for rat cardiovascular (< 250 g); contrast imaging. 12231 MS250S: 13-24 MHz operating frequency MicroScan transducer Used for mouse cardiovascular; contrast imaging. 11959 MS400: 18-38 MHz operating frequency MicroScan transducer Used for mouse cardiovascular; mouse, rat, and rabbit vascular. 11960 MS550D: 22-55 MHz operating frequency MicroScan transducer Used for mouse cardiovascular; mouse and small rat vascular. 11961 MS550S: 32-55 MHz operating frequency MicroScan transducer Used for mouse and small rat vascular. 12026 MS700: 30-70 MHz operating frequency MicroScan transducer Used for mouse vascular. Vevo 1100 Imaging & Analysis Software 11948 M-Mode M-Mode imaging is used for visualizing and quantifying tissue movement over time (e.g. motion of the myocardium over time). 11949 Pulsed-Wave Doppler Mode Pulsed-Wave (PW) Doppler Mode is used to provide analysis of blood flow at specific sites in a vessel or valve under investigation. The strength of PW Doppler Mode lies in the accurate quantification of the changing blood velocity throughout the cardiac cycle, and the distribution of velocities in the sample volume (or gate). 11951 Color Doppler Mode This advanced mode provides the researcher with the ability to quickly and accurately identify the location and presence of vessels. The benefits include increasing user efficiency with the Vevo system, but also reducing the learning time required to locate and identify target anatomy. In addition, it provides dynamic data about blood flow, which cannot be obtained from more expensive and often more complex imaging modalities. It allows for easy analysis of valvular diseases, such as the aortic, mitral, pulmonary and tricuspid valves in small animals. 11955 LV Trace Tool LV Functional Analysis will provide semi-automated continuous tracing of the chamber walls in the left ventricle in either B-Mode or M-Mode. In addition, the Vevo software will automatically generate standard left ventricular measurements and calculations derived from the traced contours and the collected physiological data. This feature will provide users with an improved and streamlined workflow for conducting standard cardiac analysis on mouse and rat models. Traced LV walls provide continuous diameter, area or volume dimensions depending on the mode used. The combination of the continuous dimensions with an integrated blood pressure signal will provide Pressure-Volume analysis with the Vevo system. VS-11962 Vevo LAB Workstation Software This workstation software is compatible with both the Vevo 2100 and the Vevo LAZR imaging systems. Allows for analysis, measurement, and annotation of Vevo data on the researcher's PC, freeing valuable time on the Vevo system itself. Includes License Dongle and Installation CD. Requires Microsoft Windows XP or Vista with a minimum of 1GB of memory (2GB recommended). EDU00526 Vevo 1100 Product Itemized List Rev. 1.5 Page 2

Other Accessories Imaging Stations and Image-Guided Injection Components VS-11982 Vevo Imaging Station 1 Bench-mounted adjustable rail system custom designed for small animal handling, positioning and imaging optimization; Fully adjustable MicroScan transducer (MSt) stand and mount; Contains MicroScan transducer (MSt) adaptor; Adjustable X,Y, and Z positioning system for Vevo Ball Joint; Includes Short Imaging Ball Joint unit (11179) for easy movement and manipulation of the animal and mounting of the small animal table; Mouse handling table (11436) or rat handling table (11550); Includes Advanced Physiological Monitoring Unit (11426) to monitor animal temperature, ECG, heart rate and blood pressure (requires external pressure input). VS-11983 Vevo Imaging Station 2 Includes Imaging Station 1 plus Imaging Station Extension with injection mount; Micro-manipulation controls; rail systemextensions; Y-Axis stage adjustment. VS-11852 Vevo Embryo Injection Expansion Set Upgrades Imaging Station 1 plus Imaging Station Extension with Injection Mount to include required rail system components for embryonic injections. Set includes: - Automated Injection System including nanoliter micro-injection pump including micromanipulator. - Control-pad operated injection and extraction. - Tall Vevo Ball Joint and Quick-Lift Unit (11278) to provide full field of motion for imaging procedures and the ability to lift animals in and out of plane for injection procedures. - Includes Image-Guided Injection Starter Kit (11059). VS-20031 Simple Vevo Imaging Station Simple and easy to use adjustable MicroScan transducer stand and mount for small animal imaging, with the MicroScan transducer adaptor included. Animal Handling Components 11436 Mouse Handling Table Utilized for mouse heating, mouse core temperature capture and ECG pads for physiological monitoring and manipulation. Includes Quick-Connect to mount to ball-joint. 11550 Rat Handling Table Utilized for rat heating, rat core temperature capture and ECG pads for physiological monitoring and manipulation. Includes Quick-Connect to mount to ball-joint, and SA-11302 14 mm Bain Circuit and 14 mm nosepiece for rat anesthesia. VS-20000 Advanced Physiological Monitoring Unit (THM150) Integrated monitor for temperature, ECG, heart rate and blood pressure of mice and rats on the Small Animal Handling Table units. For use with the Mouse (11436) and Rat (11550) Handling Table units. VS-20025 Vevo ebox Physiological monitoring of small animals via wire-based electrodes. For use with the Advanced Physiological Monitoring Unit (11426) for acquiring ECG and respiration signals from wire-based electrodes. Can be used independently, or in conjunction with the Mouse Handling Table (11436) and/or Rat Handling Table (11550) to maintain animal heating and positioning. Includes one set of stainless steel needle electrodes (50635). 50635 Stainless Steel Needle Electrodes (Set of 4) For use with the Vevo ebox (VS-20025) for acquiring ECG and respiration signals from small animals - Set of 4 electrodes to be used on all 4 limbs of animal - Multiple-use item 50636 Silver/Silver Chloride Disc Electrodes (Set of 4) For use with the Vevo ebox (VS-20025) for acquiring ECG and respiration signals from small animals - Set of 4 electrodes to be used on all 4 limbs of animal - Non-invasive, disk-style - Multiple-use item 50637 Platinum Reference Needle Electrodes (Set of 4) For use with the Vevo ebox (VS-20025) for acquiring ECG and respiration signals from small animals - Set of 4 electrodes to be used on all 4 limbs of animal EDU00526 Vevo 1100 Product Itemized List Rev. 1.5 Page 3

- Highest signal quality possible of all electrodes - Multiple-use item Vevo Anesthesia Systems & Accessories - Oxygen + Medical Air VS-12055 Vevo Compact Dual (Med. Air & O2) Anesthesia System (Tabletop Version) Self-contained isoflurane-based anesthesia unit for ease of use on lab tables. It has a compact 8 x 11 footprint. Includes a 2 Liter small animal induction chamber (3.75 x 9.0 x 3.75 ); Isoflurane Vaporizer; Anesthesia scavenger filter; Oxygen regulator; Medical air regulator; Oxygen flow meter; Medical air flow meter. VS-12056 Vevo Compact Dual (Med. Air & O2) Anesthesia System (Mobile Version) Self-contained isoflurane-based anesthesia unit mounted on a rolling cart for ease of use in research laboratories. Includes a 2 Liter small animal induction chamber (3.75 x 9.0 x 3.75 ); Isoflurane Vaporizer; Anesthesia scavenger filter; Single yoke oxygen regulator/assembly; Single yoke medical air assembly/regulator Oxygen flow meter; Medical air flow meter. EDU00526 Vevo 1100 Product Itemized List Rev. 1.5 Page 4

FUJIFILM VisualSonics, Inc. T.1.416.484.5000 Toll Free (North America) 1.866.416.4636 Toll Free (Europe) +800.0751.2020 E. info@visualsonics.com www.visualsonics.com VisualSonics, VisualSonics logo, VisualSonics dot design, Vevo, Vevo MicroMarker, VevoStrain, VevoCQ, SoniGene, RMV, EKV, MicroScan, LAZRTight, Insight through In Vivo Imaging, are registered trademarks (in some jurisdictions) or unregistered trademarks of VisualSonics Inc. 2011 VisualSonics Inc. All rights reserved. Rev 1.5