Program of the ESPGHAN Hepatology Summer School 2010 Organized by: ESPGHAN Hepatology Committee Date: 13-16th May 2010 Venue: Hotel Campanile - Cracow,, Poland Local organizer: Prof. Piotr Socha The Children s Memorial Health Institute Department of Gastroenterology, Hepatology and Immunology Al. Dzieci Polskich 20 04-730 Warsaw, Poland e-mail: p.socha@czd.pl 1
ESPGHAN Hepatology Committee Dhawan (London) Piotr Socha (Warsaw) Florence Lacaille (Paris) Lorenzo D Antiga (Bergamo) Emmanuel Jacquemin (Paris) Paloma Jara (Madrid) Patrick Mc Kiernan (Birmingham) Ozlem Durmaz (Istanbul) Pietro Vajro (Naples) Faculty Members of the ESPGHAN Hepatology Summer School 2010 Paediatric hepatology: Dhawan (London) Piotr Socha (Warsaw) Florence Lacaille (Paris) Lorenzo D Antiga (Bergamo) Ekkehard Sturm Patrick Mc Kiernan (Birmingham) Ozlem Durmaz Suoglu (Istanbul) Pietro Vajro (Naples) Joanna Pawlowska (Warsaw) Liver transplant and surgery: Piotr Kalicinski (Warsaw) Liver pathology: Alex Knisely (London) Interventional radiology: John Karani (London) 2
Microscopic imaging of the liver - what kind of SCIENTIFIC PROGRAM Day 1. 13 May Session 1. information we can obtain (normal liver, fatty liver, cholestasis)?. 15.30-16.00 Alex Functions of the liver. 16.00-16.20 Patrick Hepatomegaly 16.20-16.40 Florence Abnormal liver tests - the clinical significance. 16.40-17.10 Workshop Presentations of the participants: A. Trebst No title. Hypertransaminasemia. M. Mtegha Crigler-Najjar syndrome. Case report? J. Jahnel Lymphocyte subpopulations in MDR2 (ABCB4) knockout mice as model for sclerosing cholangitis. (2x) P. Witters ADP-degrading enzymes inhibit platelet activation in bile-duct ligated rats. C. Prell Autoimmune pancraeatitis with liver involvement. S. Heissat - Making the diagnosis of perinatal hemochromatosis. Pietro 17.20-18.30 Day 2. 14 May Session 2. Acute and chronic hepatitis Acute hepatitis (infectious, toxic, ischaemic) 8.30-9.10 Florence Diagnosis and treatment of HBV 9.10-9.50 Lorenzo Diagnosis and treatment of HCV 9.50-10.30 3
Pietro Autoimmune hepatitis and sclerosing cholangitis 10.30-11.10 Lorenzo Session 3. Metabolic liver diseases Clinical presentations of metabolic diseases 11.30-12.10 Patrick Approach to the fatty liver: NAFLD. 12.10-12.50 Wilson disease 12.50-13.20 Piotr Mitochondrial disorders 13.20-13.50 Patrick Session 4. Cholestatic liver disease Pathophysiology of cholestasis 15.00-15.30 Ekkehard Approach to a jaundiced infant- with emphasis on 15.30-16.10 extrahepatic cholestasis Joanna Inherited cholestatic disorders 16.10-16.50 Ekkehard Workshop Radiology: Ultrasound imaging of the normal liver Tumors- ultrasound, CT scanning Bile ducts- ultrasound, NMR, HIDA scanning (different pathologies- PSC, biliary atresia etc.) Portal hypertension, Budd-Chiari- Doppler, CT 17.15-18.00 Case presentations: cholestasis Cholestasis: 18.00-19.00 Abdoon H - Bile acid synthetic defects in Saudi Arabia. 7 cases. 4
B. Andreassen Jaundice in a 2 month old baby. M. Bozo Role of scintigraphy in the diagnosis of biliary atresia in developing countries. P. Witters A rare case of neonatal cholestasis: NISCH syndrome. A. Deutschmann Hepatobiliary transporter expression in children with cholstatic liver disease. M. Basso Eosinophilic cholangitis: a new entity of sclerosing cholangitis, management and outcome at 1 year. Day 3. 15 May Session 5. Complications of chronic liver disease and prehepatic block Medical complications of chronic liver disease (ascites, 8.30-9.05 hepato-renal syndrome, malnutrition) Ozlem Management of children with prehepatic and intrahepatic 9.05-9.30 block Lorenzo (how poor is the evidence) Endoscopic and surgical therapy of portal hypertension 9.30-10.00 Piotr Kalicinski&Patrick Discussion: a surgeon, a hepatologist and all participants 10.00-10.15 Session 6. Acute liver failure Acute liver failure diagnostic approach depending on 10.30-11.10 age Indications for LTx 11.10-11.35 Ozlem Medical management of acute liver failure 11.35-12.05 Pietro Interactive discussion 12.05-12.15 Lunch in the Old Market Square 12.15-15.00 5
Session 7. Liver transplantation Chronic liver disease - indications for LTx 15.00-15.35 Ozlem How to list a child for LTx - clinical and lab evaluations 15.35-16.00 needed, vaccinations... Joanna The surgical techniques for liver transplantation in 16.00-16.30 children. Piotr Kalicinski Immunosuppression and its complications 16.30-17.05 Florence Graft dysfunction 17.05-17.35 Therapy of a chronic liver disease and after LTx - 17.35-17.55 compliance Joanna&Piotr Workshop Case presentations Tumors: 18.10-19.30 AJ. Terblanche Massive hepatic hemangiomendothelioma and severe pulmonary hypertension in a 7 month old child: a case report. A. Kowalski Inflammatory myofibroblastic tumor of liver. Case report. Radiology: E. Kyrana 8 year old girl with congenital portocaval shunt. A. Rybak Liver fibrosis due to subcardiac inferior caval vein stenosis. Case report. Portal hypertension: Vuletic B - Congenital hepatic fibrosis. Case reports. Day 4. 16 May Session 8. Hot topics in paediatric hepatology 6
Hepatocyte transplantation 8.30-9.00 What is new in metabolic and autoimmune diseases- shared 9.00-10.00 EU projects and other important projects 10.00-10.25 Scientific writing: originality, methods used. Presentation and panel discussion exemplified Case presentations LTx: P. Czubkowski Non-surgical approach to biliary complications after liver transplantation in children M. Bosisio Management of hepatopulmonary syndrome in children. A single centre report. S. Almeida PTLD experience in a pediatric liver transplant unit. Piotr&Lorenzo&&Pietro&Patrick 10.25-10.50 Piotr 11.05-11.30 Synthesis of presentations & discussions. 11.30-12.00 Evaluations and closing remarks. 7