Hematology Reference Intervals ECH HCIS

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ECH HCIS Applicability: This document applies to all Central Zone Meditech Ring-ECH HCIS personnel of and laboratories administered under the Convenant Health Group and the Lamont Health Centre collectively referred to here as Laboratory Services. Purpose: To provide reference intervals for laboratory analytes. Test Westergren ESR (mm/hr) BD Seditainer CSF Analysis Retic Semen Analysis D-dimer mg/l (DDU) Reference Range Adult: Male 0-15 mm/hr Female 0-20 mm/hr Children (less than 18 years) 0-10 mm/hr Normal CSF Color: colorless Clarity: clear RBC: 0 x 10 6 /L WBC: 0-5 x 10 6 /L Absolute < 6 months No reference range > 6 months 20-90 x 10 9 /L Volume 1.5 5.0 ml ph 7.2 8.0 Motility 40% at 1 hour Count/litre >20 x 10 9 /L WBC 0-5 /hpf 0.5 Report Comment: A D-Dimer level BELOW the 0.50 mg/l cutoff may be used with the standardized clinical assessment and/or imaging studies to help exclude venous thromboembolism (VTE). Values above the cutoff are not diagnostically useful in VTE assessment. Initials: Site: Date Printed: Page 1 of 5

COMPLETE BLOOD COUNT WHITE BLOOD CELL (X10 9 /L) RED BLOOD CELL (X10 12 /L) HEMO- GLOBIN (g/l) HEMAT O-CRIT L/L MCV (f1) MCH (pg) MCHC (g/l) RDW PLATELET COUNT (X10 9 /L) 0 day 9.0-33.0 3.9-5.5 135-195.42 -.60 98-118 26-35 330-360 * <15.6 140-450 1 day 9.4-34.0 4.0-6.6 145-225.45 -.67 95-121 26-35 290-360 * <15.6 140-450 7 days 5.0-21.0 3.9-6.3 135-215.42 -.66 88-126 26-35 280-360 * <15.6 140-450 14 days 5.0-20.0 3.6-6.2 125-205.39 -.63 86-124 26-35 280-360 * <15.6 140-450 1 month 5.0-19.5 3.0-5.4 100-180.31 -.55 85-123 26-35 290-360 * <15.6 140-450 2 months 5.0-19.5 2.7-4.9 90-140.28 -.42 77-115 26-35 290-360 * <15.6 140-450 3 months 5.0-19.5 3.1-4.5 95-135.29 -.41 74-108 26-35 300-360 * <15.6 140-450 6 months 6.0-17.5 3.7-5.3 105-135.33 -.39 70-86 26-35 300-360 * <15.6 140-450 2 years 6.0-17.0 3.9-5.3 115-135.34 -.40 75-87 26-35 310-360 * <15.6 140-450 4 years 5.5-15.5 3.9-5.3 115-135.34 -.40 75-87 26-35 310-360 * <15.6 140-450 6 years 5.0-14.5 4.0-5.2 115-155.35 -.45 77-95 26-35 310-360 * <15.6 140-450 8 years 4.5-13.5 4.0-5.2 115-155.35 -.45 77-95 26-35 310-360 * <15.6 140-450 12 years 4.5-13.5 16 years 4.5-13.0 F 4.1-5.1 M 4.5-5.3 F 4.1-5.1 M 4.5-5.3 M 130-170 M 130-170 > 18 years ADULT 4.0-11.0 F 3.8-5.2 M 4.3-6.0 M 135-175 critical <0.6 or >99.9 > 3 months values <80, >190 < 3 months <80 M.37 -.49 M.37 -.49 F 78-100 M 78-98 26-35 310-360 * <15.6 140-450 F 78-100 M 78-98 26-35 310-360 * <15.6 140-450 M.41 -.52 80-100 26-35 320-360 * <15.6 140-450 < 30 *MCHC upper limit for Sysmex instrument is 370 Initials: Site: Date Printed: Page 2 of 5

Manual WBC Differential AGE NEA x10 9 /L LYA x10 9 /L MOA x10 9 /L EOS x10 9 /L BAA x 10 9 /L 0 days 6.0-26.0 2.0-11.0 < 3.5 < 2.0 < 0.4 1-6 days 5.0-21.0 2.0-11.5 < 3.5 < 2.0 < 0.4 7-13 days 1.5-10.0 2.0-17.0 < 1.8 < 1.7 < 0.4 2-4 weeks 1.0-9.5 2.0-17.0 < 1.8 < 1.7 < 0.4 1-5 months 1.0-9.0 2.5-16.5 < 1.0 < 0.7 < 0.3 6-11 months 1.0-8.5 4.0-13.5 < 1.0 < 0.7 < 0.3 1 year 1.5-8.5 4.0-10.5 < 1.0 < 0.7 < 0.3 2-3 years 1.5-8.5 3.0-9.5 < 1.0 < 0.7 < 0.3 4-5 years 1.5-8.5 2.0-8.0 < 1.0 < 0.7 < 0.3 6-7 years 1.5-8.0 1.5-7.0 < 1.0 < 0.7 < 0.3 8-9 years 1.5-8.0 1.5-6.8 < 1.0 < 0.7 < 0.3 10-15 years 1.8-8.0 1.5-6.5 < 1.0 < 0.7 < 0.3 16-17 years 1.8-8.0 1.2-5.2 < 1.0 < 0.7 < 0.3 > 18 years 1.8-7.5 1.0-4.5 < 1.1 < 0.7 < 0.3 CRITICAL < 0.6 All ages Blasts Malaria >2 % blasts in a new patient. If not known, call pathologist on call or notify ordering physician. Presence of malaria. If not known, call pathologist on call or notify ordering physician. Sysmex Analyzer (Three Part Differential) Age Neutrophils Lymphocyte Mixed or Other 0 day 6.0-26.0 x 10 9 / L 2.0-11.0 x 10 9 / L 0-5.9 x 10 9 / L 1 day 5.0-21.0 x 10 9 / L 2.0-11.5 x 10 9 / L 0-5.9 x 10 9 / L 7 days 1.5-10.0 x 10 9 / L 2.0-17.0 x 10 9 / L 0-3.9 x 10 9 / L 14 days 1.0-9.5 x 10 9 / L 2.0-17.0 x 10 9 / L 0-3.9 x 10 9 / L 1 month 1.0-9.0 x 10 9 / L 2.5-16.5 x 10 9 / L 0-2.0 x 10 9 / L 6 months 1.0-8.5 x 10 9 / L 4.0-13.5 x 10 9 / L 0-2.0 x 10 9 / L 1 year 1.5-8.5 x 10 9 / L 4.0-10.5 x 10 9 / L 0-2.0 x 10 9 / L 2 years 1.5-8.5 x 10 9 / L 3.0-9.5 x 10 9 / L 0-2.0 x 10 9 / L 4 years 1.5-8.5 x 10 9 / L 2.0-8.0 x 10 9 / L 0-2.0 x 10 9 / L 6 years 1.5-8.5 x 10 9 / L 1.5-7.0 x 10 9 / L 0-2.0 x 10 9 / L 8 years 1.5-8.0 x 10 9 / L 1.5-6.8 x 10 9 / L 0-2.0 x 10 9 / L 10 years 1.8-8.0 x 10 9 / L 1.5-6.5 x 10 9 / L 0-2.0 x 10 9 / L 16 years 1.8-8.0 x 10 9 / L 1.2-5.2 x 10 9 / L 0-2.0 x 10 9 / L > 18 years 1.8-7.5 x 10 9 / L 1.0-4.5 x 10 9 / L 0-2.1 x 10 9 / L < 0.6 x 10 9 / L Initials: Site: Date Printed: Page 3 of 5

Beckman - Coulter Analyzer (Three Part Differential) Age Granulocytes Lymphocyte Monocyte 0 day 6.0-28.4 x 10 9 / L 2.0-11.0 x 10 9 / L 0-3.5 x 10 9 / L 1 day 5.0-23.4 x 10 9 / L 2.0-11.5 x 10 9 / L 0-3.5 x 10 9 / L 7 days 1.5-12.1 x 10 9 / L 2.0-17.0 x 10 9 / L 0-1.8 x 10 9 / L 14 days 1.0-11.6 x 10 9 / L 2.0-17.0 x 10 9 / L 0-1.8 x 10 9 / L 1 month 1.0-10.0 x 10 9 / L 2.5-16.5 x 10 9 / L 0-1.0 x 10 9 / L 6 months 1.0-9.5 x 10 9 / L 4.0-13.5 x 10 9 / L 0-1.0 x 10 9 / L 1 year 1.5-9.0 x 10 9 / L 4.0-10.5 x 10 9 / L 0-1.0 x 10 9 / L 2 years 1.5-9.0 x 10 9 / L 3.0-9.5 x 10 9 / L 0-1.0 x 10 9 / L 4 years 1.5-9.0 x 10 9 / L 2.0-8.0 x 10 9 / L 0-1.0 x 10 9 / L 6 years 1.5-9.0 x 10 9 / L 1.5-7.0 x 10 9 / L 0-1.0 x 10 9 / L 8 years 1.5-9.0 x 10 9 / L 1.5-6.8 x 10 9 / L 0-1.0 x 10 9 / L 10 years 1.8-9.0 x 10 9 / L 1.5-6.5 x 10 9 / L 0-1.0 x 10 9 / L 16 years 1.8-9.0 x 10 9 / L 1.2-5.2 x 10 9 / L 0-1.0 x 10 9 / L > 18 years 1.8-8.5 x 10 9 / L 1.0-4.5 x 10 9 / L 0-1.1 x 10 9 / L < 0.6 x 10 9 / L Beckman-Coulter Analyzer (Five Part Differential) Age Neutrophils Lymphocyte Monocyte Eosinophil Basophil 0 day 6.0-26.0 x 10 9 / L 2.0-11.0 x 10 9 / L 0-3.5 x 10 9 / L 0-2.0 x 10 9 / L 0-0.4 x 10 9 / L 1 day 5.0-21.0 x 10 9 / L 2.0-11.5 x 10 9 / L 0-3.5 x 10 9 / L 0-2.0 x 10 9 / L 0-0.4 x 10 9 / L 7 days 1.5-10.0 x 10 9 / L 2.0-17.0 x 10 9 / L 0-1.8 x 10 9 / L 0-1.7 x 10 9 / L 0-0.4 x 10 9 / L 14 days 1.0-9.5 x 10 9 / L 2.0-17.0 x 10 9 / L 0-1.8 x 10 9 / L 0-1.7 x 10 9 / L 0-0.4 x 10 9 / L 1 month 1.0-9.0 x 10 9 / L 2.5-16.5 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 6 months 1.0-8.5 x 10 9 / L 4.0-13.5 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 1 year 1.5-8.5 x 10 9 / L 4.0-10.5 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 2 years 1.5-8.5 x 10 9 / L 3.0-9.5 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 4 years 1.5-8.5 x 10 9 / L 2.0-8.0 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 6 years 1.5-8.0 x 10 9 / L 1.5-7.0 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 8 years 1.5-8.0 x 10 9 / L 1.5-6.8 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 10 years 1.8-8.0 x 10 9 / L 1.5-6.5 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L 16 years 1.8-8.0 x 10 9 / L 1.2-5.2 x 10 9 / L 0-1.0 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L >18 years 1.8-7.5 x 10 9 / L 1.0-4.5 x 10 9 / L 0-1.1 x 10 9 / L 0-0.7 x 10 9 / L 0-0.3 x 10 9 / L < 0.6 x 10 9 / L Initials: Site: Date Printed: Page 4 of 5

References: Complete Blood Count Normal Ranges adopted from modified CHA hematology reference ranges, April 2004. CHA published Reference Range (Reticulocytes and CSF), Guide to Laboratory Services, April 1999. A.D.A.M., Inc., ESR Overview, The New York Times Health Guide, reviewed June 18, 2007. Initials: Site: Date Printed: Page 5 of 5