COLLAGEN PEPTIDES FOR A HEALTHY AGING

COLLAGEN PEPTIDES FOR A HEALTHY AGING Collagen Peptides for a Healthy Lifestyle PRODUCED & MARKETED BY ROUSSELOT

THE KEY TO HEALTHY AGING STAYING ACTIVE FOR IMPROVED QUALITY OF LIFE By 2050, all major areas of the world will have nearly a quarter or more of their populations aged 60 or over according to United Nation (2015). Staying healthy and maintaining an active lifestyle is crucial for many of these people. But often, with advancing years, come joint stiffness, brittle bones and loss of muscle strength all of which can restrict or even prevent easy movement and reduce overall quality of life. Getting enough nutrients and combining with regular exercises are keys to maintaining mobility and quality of life. AT 60+ YEARS, STATISTICS SHOW 20% OF ALL WOMEN SUFFER FROM JOINT PROBLEMS 10% OF ALL MEN SUFFER FROM JOINT PROBLEMS 100% Quality of life Optimization of quality of life 1 IN 3 WOMEN WILL EXPERIENCE BONE FRACTURES 30% OF PEOPLE ARE AFFECTED BY LOSS OF MUSCLE MASS AND STRENGTH 50% International Osteoporosis Foundation Fact Sheets Older consumers are becoming more proactive and are keen to take control of their personal health and wellbeing. 40 Years 80 Years They want proven solutions that enable them to stay active and limit the physical impact of aging. Modified from WHO/HPS, Geneva 2000

SUPPORTED BY SCIENCE The most abundant protein in the body, collagen is a key constituent of all connective tissue such as skin, bones, muscle, cartilage, tendons and ligaments. It provides the infrastructure of the musculoskeletal system, essential for mobility. Peptan collagen peptides are manufactured using a unique enzymatic hydrolysis process, which creates highly bioavailable and digestible bioactive peptides. Extensive in vitro, in vivo and clinical studies have proven their efficacy and provide evidence that Peptan can help promote healthy joints and improve bone strength and density. Collagen peptides can also support lean muscle mass. Promotes bone health MOBILITY This process is called bone remodeling, or bone turnover. In healthy adults, bone turnover replaces approximately 15% of bone mass. The peak bone mass where bones are at their most dense is reached at the age of early 20s. As we age bone resorption can begin to exceed bone formation. Collagen is the main protein found in bone. Peptan is proven to stimulate osteoblasts (bone formation cells), restore BMD and improve bone strength. 4,5,6,7 It can also be combined with calcium and vitamin D to offer significant benefits. IMPROVING MUSCLE MASS Sarcopenia is the age-related loss of muscle mass and function. Exercise and adequate intake of easily digestible protein is vital to counteracting the condition's effects. The recommended protein intake for healthy adults is 0.8g/kg body weight per day. 8 However, older people can benefit from a higher intake which is often difficult as their diets often lack protein. As a bioactive protein, Peptan can help maintain lean body mass in older adults. Research has shown collagen peptides are more effective in maintaining nitrogen balance in elderly women than whey protein indicating they are better suited to maintaining muscle mass for this target audience. 9 Enhances muscle regeneration Maintains healthy joints SCIENTIFIC REFERENCES 1 Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study, Agro FOOD Industry Hi Tech 25: 19-23 2 Oesser, S., et al., 1999, Oral Administration of 14C Labelled Gelatine Hydroslysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL), Journal of Nutrition, 129: 1891-1895 MAINTAINING HEALTHY JOINT Increase of age and overuse of joints are among the two risk factors to cause joint discomfort. Collagen makes up 95 per cent of cartilage and a daily intake of Peptan collagen peptides has been shown in a randomized, placebo-controlled, doubleblind clinical trial to reduce joint discomfort and improve joint health. 1 Peptan is proven to stimulate chondrocytes (cartilage cells) to produce more aggrecan and collagen type 2, the two main components of cartilage so preserving healthy joints. 2,3 BETTER BONE DENSITY Throughout a person s lifetime, bones continue to grow, old bone tissues break down (bone resorption) and new bones tissues are being added to the skeleton (bone formation). 3 2011. Rousselot in vitro study. Atlantic Bone Screen, France 4 Guillerminet, F., et al., 2010, Collagen Peptides Improves Bone Metabolism and Biomechanical Parameters in Ovarietomized Mice: An In-Vitro and In Vivo Study, Bone 5 Guillerminet, F. et al, 2012, Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International 23 (7): 1909-1919 6 Daneault, A. et al, 2014, Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo.osteoarthritis and Cartilage 22: S131 7 Daneault, A. et al., 2015. Biological effect of hydrolyzed collagen on bone metabolism. Critical Reviews in Food Science and Nutrition, 10: 1040-8398 8 WHO Technical Report Series 935 9 Hays et al., 2009, Effects of Whey and Fortified Collagen Hydrolysate Protein Supplements on Nitrogen Balance and Body Composition in Older Women, Journal of the American Dietetic Association

THE BUILDING BLOCKS FOR INNOVATIVE PRODUCTS Peptan s proven health benefits make it the natural choice for manufacturers looking to boost the nutritional profile of their foods and drinks, and develop proven health solutions to meet the needs of healthy agers. Its ease of use, neutral taste and odor, solubility and heat resistance ensure Peptan can be easily incorporated into a range of formulations from beverages and powder drinks to dairy products, protein bars, gummies, plus dietary supplements. Peptan is also 100 per cent natural and clean label, opening up even more opportunities for functional food and nutraceutical manufacturers. In addition to its healthy aging advantages, Peptan also delivers proven benefits for beauty from within and sports nutrition. ASK THE EXPERTS Rousselot offers the widest range of collagen peptides for a variety of formulation needs. With application laboratories located around the world, Rousselot is continuously developing new product concepts and recipes to support our customers innovation focus. Our technical experts are available to provides local application advice to customers, anywhere in the world. Rousselot also offers local regulatory support and provide scientific evidence files to back up the efficacy of Peptan. QUALITY FIRST Peptan is manufactured by Rousselot in France and Brazil in state-of-the-art certified plants meeting the highest international food and quality standards with full traceability throughout the process. Peptan are premium quality collagen peptides; 100 per cent natural, safe and free from any preservatives or additives.

INTRODUCING AN EXCITING MARKET OPPORTUNITY OVER 60 S BY REGION* Europe North America 21% 28% 24% 34% Asia 12% 25% Africa 5% 9% 2015 2050 Latin America 11% 26% 16% Oceania 23% As the number of older consumers grows, the market for products to support healthy aging and mobility becomes one of significant potential. In fact, Health Focus International reports that 48 per cent of consumers have expressed a strong interest in products offering health benefits which help maintain bone, joint and muscle function. To make the most of this considerable demand, manufacturers should select effective ingredients to enable them to develop innovative and appealing end products that deliver the mobility advantages today s healthy agers are looking for. Peptan collagen peptides can deliver multiple consumer benefits and offer a unique solution to respond to this growing market need. Today, Peptan is a recognized and trusted ingredient brand by marketers and consumers across many markets. World Population Prospects: The 2015 Revision, United Nations

OUR SALES OFFICES AROUND THE WORLD EUROPE, MIDDLE EAST, AFRICA europe@rousselot.com Northern, Central and Eastern Europe, UK and Ireland Rousselot B.V.B.A. Meulestedekaai 81 9000 Gent Belgium +32 09 255 18 60 France, Southern Europe, Middle-East, Africa Rousselot S.A.S. 4 rue de l abreuvoir 92400 Courbevoie France +33 01 46 67 87 00 Spain and Portugal Rousselot Gelatin S.L. Paratge Pont de Torrent, S/N 17464 Cervia de Ter (Girona) Spain +34 972 49 67 00 Your Rousselot and Peptan sales contact information: SOUTH AMERICA AND CENTRAL AMERICA rousselot.brasil@rousselot.com Brazil Rousselot Gelatinas Do Brasil S.A. Rua Santo Agostinho, N 280 Distrito de Arcadas CEP 13908-080 Amparo - São Paulo Brasil + 55 19 3907 9000 South and Central America (except Brazil) Rousselot Argentina S.A. Avenida Gobernador Vergara 2532 1688 Villa Tesei - Hurlingham (Provincia de Buenos Aires) Argentina + 54 11 44 89 81 00 NORTH AMERICA AND MEXICO gelatin.usa@rousselot.com Rousselot Inc. 1231 South Rochester Street, Suite 250 Mukwonago, WI 53149 USA +1 888 455 3556 CHINA info@rousselotchina.com Rousselot China 25/A, No. 18 North Cao Xi Road Shanghai PO: 200030 China +86 21 6427 7337 JAPAN AND SOUTH KOREA japan@rousselot.com Rousselot Japan K.K. Ishikin-nihonbashi Bldg, 6F 4-14-7 Nihonbashihoncho, Chuo-Ku, Tokyo 103-0023 Japan +81 3 5643 7701 SOUTH EAST ASIA sea@rousselot.com Taiwan, Hong Kong, Australia, New Zealand, India and Sri Lanka Rousselot (M) SDN. BHD. Block P3-21, Plaza Damas Jalan Sri Hartamas 1 50480 Kuala Lumpur Malaysia +603 6201 8282 About Rousselot and Peptan: Rousselot and Peptan are both brands of Darling Ingredients Inc. Rousselot is the global leader of gelatin and collagen peptides. Rousselot s wide range of collagen peptides are marketed under the Peptan brand. We work in partnership with our customers all over the world, delivering innovative and advanced ingredient solutions manufactured through state of the art operations. We help our customers achieve their goals, enabling them to create world class pharmaceutical, food and nutritional products to inspire and excite today s demanding consumers. All rights reserved. No part of this brochure may be reproduced, distributed or translated in any form or by any means, or stored in a database or retrieval system, without the prior written permission of Rousselot. Rousselot alone retains the copyright to the entire content of this brochure and the intellectual property rights to all designations of our products stated in this brochure and intellectual property rights to the products themselves. Nothing in this brochure constitutes a license (explicit or implicit) of any of Rousselot s intellectual property rights. The duplication or use of product designations, images, graphics and texts is not permitted without Rousselot s explicit prior written consent. Rousselot makes no representation or warranty, whether expressed or implied, of the accuracy, reliability, or completeness of the information, nor does it assume any legal liability, whether direct or indirect, of any information. Use of this information shall be at your discretion and risk. Nothing herein relieves you from carrying out your own suitability determinations and tests and from your obligation to comply with all applicable laws and regulations and to observe all third party rights. This product is not intended to diagnose, treat, cure, or prevent any disease. You should always consult your medical provider when using the product together with medical treatments, diets or fitness programs. The uses and claims for Rousselot s products recommended in the brochure should be adapted to the current local regulatory environment. This statement has not been evaluated by the Food and Drug Administration. Rousselot SAS. RCS Nanterre 442743126 (France) - Pictures: Rousselot,Shutterstock, istockphoto, CanStockPhoto - Design: wearewim.com - 03-2016 - V1.0 Rousselot Headquarters: Rousselot B.V. Kanaaldijk Noord 20-21 5691 NM Son The Netherlands Phone: +31 (0) 499 364 100 Fax: +31 (0) 499 364 972 peptan@rousselot.com peptan.com PeptanbyRousselot @Peptan_Global Collagen Peptides PRODUCED & MARKETED BY ROUSSELOT