Installation and Operational Qualification Protocol (Reference: SOP )



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Project Name Equipment Process Line/Location Project Number Serial Number Model Number Protocol number WRITTEN BY: REVIEWED BY: Position APPROVAL TO EXECUTE: Position: PROTOCOL COMPLETION APPROVAL: Position: 1 OBJECTIVE The objective of this protocol is to define the Installation Qualification (IQ) and Operational Qualification (OQ) requirements and acceptance criteria for the [insert system name and plant number] which will be located in the [insert area, packaging or manufacturing] at site [insert site name]. IQ/OQ is required as [insert brief description as to why required, e.g. as it is new equipment. Successful completion of this protocol will provide a high degree of assurance that the equipment has been installed and operates in accordance with the site requirements, specifications and manufacturers recommendations and is in compliance with cgmp and site policies. Page 1 of 18

Test 001: Verification of Installed Equipment The objective of this test is: 1. To verify that equipment is uniquely identified and installed in accordance with site and manufacturers recommendations 2. To verify that equipment is scheduled for preventative maintenance 3. To ensure that the equipment installed is documented for change control / revalidation purposes Inspect the installed equipment and record details of all major process equipment as required below. Verification of installed components may be achieved by visual inspection or approved documentation / drawings. If a document or drawing is used it must be referenced. All equipment must be uniquely identified and installed in accordance with site and manufacturers recommendations. All major equipment items should be included for preventative maintenance [Insert Equipment Name. If subsystems include one row for each sub system] [Insert Equipment Name. If subsystems include one row for each sub system] Equipment Description Installed Initial & Date Model Serial number Plant No Maintenance log No Model Serial number Plant No Maintenance log No Page 5 of 18

Test 005: Verification of Computer System Software The objective of this test is: 1. To verify that all computer system Operating Software and Application Software integrated with the system is uniquely identified and installed in accordance with site and manufacturers recommendations. 2. To ensure that the software components of the installation are documented for change control/re-validation purposes. Inspect the installed software and record details. Verification of installed components may be achieved by visual inspection or approved documentation / drawings. If a document or drawing is used it must be referenced. 1. All software must be uniquely identified and installed in accordance with site and manufacturers recommendations. 2. A backup copy of the software must be available. [Insert system name] Software Description Installed Initial & Date Operating Software name Operating Software version Application Software name Application Software version Application Software Developer Location of backup Page 9 of 18

Test Ref: 010: Verification of Safety The objective of this test is to verify that EHS are notified that qualification of the system is being undertaken and a safety audit if required can be performed. Contact the EHS representative and determine if a safety audit is required prior to performing any OQ testing If required enter the estimated completion date for the audit. It is the responsibility of EHS to complete this test and to ensure that the equipment is safe for operational qualification and for use. The need for a safety audit has been established prior to OQ and if required a safety audit has been conducted by EHS and the equipment is deemed suitable for routine use. Test # Test Procedure Actual Initial & Date 1 Determine if a safety audit is required 2 Enter the estimated completion date for the safety audit if required 3 Document if the system is considered safe for operational qualification Audit required? Page 14 of 18

APPENDIX [Insert Appendix No] DEVIATION LOG AND REPORT DEVIATION REPORT NO.: TEST SCRIPT / TEST PROCEDURE #: 1. DEVIATION DESCRIPTION: Circle Classification Critical Deviation Non- Critical Deviation Circle Change Required Yes Change # 2. RESOLUTION (attach any re-test results to this sheet): No Deviation # COMMITMENT # Resolution Completed & Deviation Resolved: (yes/no) 3. JUSTIFICATION FOR ACCEPTANCE OF DEVIATION: Justification Completed & Deviation Accepted: (yes/no) Approved By: (System Owner) Approved By: (Validation) Approved By: (Quality Assurance) Print/Type Name Signature Date Page 18 of 18