Brain Structures That are Involved with Memory



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Early Theories of Brain Structures That are Involved with Psychology 372 Sensation Sensory Attention Rehearsal STM Storage Retrieval Physiological Psychology Steven E. Meier, Ph.D. Listen to the audio lecture while viewing these slides 1 2 Sensory In sensory memory, sensory impressions are stored in a form similar to the original sensation. Several subgroups. Iconic Related to the visual system Are visual images in the retina and the brain. Lasts approximately.25 seconds. Can last longer. Why? Processing in Bipolar, Ganglion, Amacrine, and Horizontal cells. 3 4 Echoic Related to the auditory system Auditory sounds that last in the Cochlea and Temporal Lobe. Lasts 2 seconds or less. Can last longer. Why? Waves occurring in the cochlea Short Term Two components Events that just occurred are still in consciousness Are different from events that need to be brought back by recall from Long Term. 5 6

Information in STM can do One of Three Things. It can be rehearsed and remain in STM It is not rehearsed and is forgotten It can go into the next stage () 7 plus or minus two Miller you can generally only store 7 plus or minus two items in short term memory. Lasts a short period of time (10 20 seconds). 7 8 Long Term Later Theories of Is where information goes into the system and is retained Rehearsal Duration - apparently forever Penfield Studies Sensation Sensory Attention Working Storage Retrieval 9 10 Uses a Computer Model Classification of Sensory Working Input from keyboard RAM Storage System/Hard Drive Many Schemes 11 12

Sensory Short Term Long Term Memories Classification of Types of Long Term Many types Episodic Memories Declarative Visual Procedural Procedural Declarative Memories Semantic Episodic 13 14 Episodic Memories Is a memory for a specific event. What happened, where did it happen, etc. Declarative Is memory for items of knowledge. Is independent of the particular occasion in which one acquired them. Is the sum of all acquired knowledge. All works, symbols, facts of words, appearance of objects, principles, schemas, scripts. etc. we have. 15 16 Visual Eidetic (I de Tic) Imagery (photographic memory) Individuals can recall detailed images of visual scenes for long periods of time Is very rare 5% of kids Less for adults Kids rely more on imagery than adults Procedural for physical things Riding a bike 17 18

More Accurate Representation Implicit (Non-Declarative) Explicit (Declarative) Implicit (Non-Declarative) Involves training reflexive behavior or procedural skills Is recalled unconsciously Is more rigid Is more connected to the stimulus conditions where the knowledge was learned 19 20 Explicit (Declarative) Is knowledge of people, places, things and what they mean Is recalled by deliberate, conscious effort Is highly flexible Involves the association of multiple pieces of information Two components Episodic memory (First Kiss) Semantic memory (Knowledge from texts) 21 Explicit (Declarative) Explicit/Declarative Facts Specific Eve nts Prim ing Procedural Skills Habits Implicit/Nondeclarative Associative CC Operant Nonassociative Habituation Sensitization 22 Some Structures Involved With Cortex Amygdala Cerebellum Reflex Pathways Thalamus Hippocampal Formation Entorhinal Cortex Others 23 Explicit/Declarative Implicit/Nondeclarative Facts Medial Temporal Lobe Specific Eve nts Structures Prim ing Procedural Skills Habits Emotional Responses Associative CC Operant Skeletal Neocortex Striatum Amygdala Cerebellum Nonassociative Habituation Sensitization Reflex Pathw ays 24

Explicit Psyc 372 Physiological Pathways Psychology Begins in polymodal association cortices (prefrontal, limbic, parieto-occipital-temporal) Processes visual, spatial, and somatic memory Information is conveyed to parahippocampus and perirhinal cortical structures Conveyed to entorhinal cortex Conveyed to dentate gyrus Conveyed to hippocampus Hippocampal Formation Conveyed to subiculum Conveyed back to entorhinal cortex Sent back to perirhinal and parahippocampus Back to polymodal association cortices of neocortex 25 Entorhinal Cortex For location see Figure 13.5 Gets input from Association Cortex Fornix Amygdala Sends information to the dentate gyrus via the Perforant Pathway. Is the critical pathway to get information from the association cortices to the hippocampus. Is also the major output structure from the hippocampus Thus, information comes from both association cortices and hippocampus and converges. Usually the earliest structure for damage that occurs in Alzheimer s Disease 26 Hippocampal Formation Hippocampal Anatomy Includes dentate gyrus the CA fields of the hippocampus subiculum Sends inputs to the hippocampal formation Receives outputs of hippocampal formation Is crucial for the formation of new memories 27 28 Hippocampus Overall Plays a major role in encoding and storing information. With damage, you have difficulty storing and recalling information. Generally, the information is not appropriately coded due to insufficient elaboration. With damage, new information is not stored, but old information remains intact. ACh. Is involved in theta rhythms of hippocampus Block ACh. get disruption of spatial working memory ACH agonism can reverse effects associated with diminished cholinergic function Called Anterograde Amnesia 29 30

Other Structures - Thalamus Is also involved with memory formation. Is thought to give the message to print the memory initially. With damage, memory traces never get created to begin with. So, it isn t stored in either Short Term or Long Term. Summary So with damage to the Hippocampus, memory is formed but due to elaboration problems, it is not properly encoded. With the Thalamus, the memory never gets formed at all. 31 32 Cerebellum Thompson Conditioned a eye blink response and a leg movement response. Lesioned the area that disrupted the eyeblink response. Result, the leg response was unaffected. Then moved 1 millimeter closer to the middle of the brain and lesioned. Result, found the conditioned leg response was affected but the eyeblink Conclusion Isolated procedural memories have unique pathways in the Cerebellum. Also get the same response when you remove Hippocampus. was not. 33 34 Cortex Lots of locations related to memory. Tends to be related to the type of memory involved. Mostly in the frontal lobe in a variety of structures. Sensation Cortex Sensory Attention RAS and Thalamus Rehearsal STM Storage Hippocampus Cortex 35 36