Mani Pavuluri MD PhD Professor and Director Pediatric Brain Research and Intervention Center Berger-Colbeth Endowed Chair in Child Psychiatry
Focus of the Talk fmri Activity Studies fmri Treatment Studies fmri Connectivity Studies A Dimensional Model in Child Psychiatry
Reason to Investigate: Neurocognitive Function in PBD Pavuluri et al, 2006, Am J Psych
Longitudinal Study: Neurocognitive Problems Don t Go Away Pavuluri et al, 2009, JACAAP
fmri Activity Studies - Mapping the Real Estate in PBD Pavuluri and Sweeney, 2008 JAACAP
fmri Activity Studies
Fronto-limbic Affective Circuit TASK FINDING HC VPFC PBD DLPFC STG PBD-HC V1/V2 V1/V2 Amygdala OPERATION Euthymic unmedicated sample Pavuluri et al, 2006 Biol Psych
Face Response Circuit TASK FINDING DLPFC OFC Insula STS V1/V2 MTG OPERATION Euthymic unmedicated sample Pavuluri et al, 2006 Biol Psych
Pavuluri et al, 2009 JAACAP Occipito-Limbic Circuit (Reactive Circuit) TASK FINDING OPERATION Euthymic unmedicated sample
Pavuluri et al, 2008 Psych Neuroimage Interfacing Circuit TASK FINDING PBD HC PBD - HC OPERATION Euthymic unmedicated sample
Cognitive Circuit TASK FINDING LAMOTRIGINE IMPROVES FRONTO-STRIATAL ACTIVITY GO TRIAL STOP TRIAL OPERATION Unmedicated Sample at Baseline Pavuluri et al, 2010 J Clin Psych
fmri Treatment Studies
Lamotrigine Increases VLPFC Activity and Decreases Amygdala Activity TASK Keep in mind? Keep in working memory store ANGRY FACE CONDITION BASELINE ANGRY FACE CONDITION AT FOLLOW-UP VS. BASELINE (Based on task used in Passarotti et al., 2010) Passarotti et al, 2011 Psychopharmacology
DBRCT of Divalproex vs. Risperidone: Differential Activity During Affective Working Memory Paradigm Left VLPFC Left Ventral Striatum Pavuluri et al, 2010, ACNP
Pavuluri et al, in press Risperidone and Divalproex: Treatment Effects Risperidone: Responders vs. Non-responders Divalproex: Responders vs. Non-responders Amygdala Medial PFC Color matching Paradigm
fmri Connectivity Studies
Affective Working Memory Paradigm Passarotti et al, 2011 PBD Conference Affect Evaluation and Regulation Network Direct Comparison Between Groups (Two Sample t-test)
Passarotti et al, submitted Affect Evaluation and Regulation Network Between-Group Differences in activation in the Affect Evaluation and Regulation Network. Red indicates greater brain region engagement in PBD than in HC, blue indicates the opposite Group differences in ACC, VLPFC, amygdala and PHG Temporal correlation fit of BOLD fmri signal change to face emotion in PBD and in HC
Wegbreit et al, 2011 PBD Conference Functional Connectivity PBD and HC Over the Duration of Trial EVALUATIVE AFFECTIVE CIRCUIT REACTIVE AFFECTIVE CIRCUIT
Treatment Effects in Real-Time Divalproex Pre and Post Treatment Evaluative Affective Circuit Wegbreit et al, 2011 PBD Conference
Treatment Effects in Real-Time Risperidone Pre and Post Treatment Evaluative Affective Circuit Wegbreit et al, 2011 PBD Conference
Evaluative Affective Circuit Recruited During Response Inhibition Risperidone engaged left insula Divalproex engaged subgenual cingulate cortex Wegbreit et al, 2011, PBD conference
Risperidone and Divalproex: Reactive Affective Circuitry During Response Inhibition Amygdala is engaged poorly even after treatment Wegbreit et al, 2011, PBD conference
Amygdala Activity is More Engaged in Responders vs. Non-Responders Amygdala in Fronto-limbic Circuit Wegbreit et al, in progress
Pioneering Work in the Field - Reflecting Pediatric BRAIN Center Alessandra Passarotti PhD Ezra Wegbreit PhD Lisa Lu PhD Binu Vargese MA Richard Whitley MA James Ellis BA Jacklynn Fitzgerald BA Jon O Neil BA Allison Lowes BA Meredith Wong BA Stephanie Monroe BA Bryn Levitan BA Nicole Witowski BA Nathan Carley BA Noah Yulish BA Gail Schuck BA Jean Madigan BA MRI Methodology Minjie Wu PhD Joe Zhou PhD Deb Little PhD Genomics and Neurochemistry Jeff Bishop Pharm D Christian Gossett BA Clinical Sonali Nanayakkara MD Julie Carbray DNSc Amy West PhD Sally Weinstein PhD Collaborators John Sweeney PhD Mike Stevens PhD
A Dimensional Model in Child Psychiatry
Developmental Affective Neuroscience: Framework for Studying Dimensions of Wellness and Illness Pavuluri et al, submitted
The Pediatric Brain Research And Intervention Center Phone: (312) 413-1710 www/psych.uic.edu/brain-center The Pediatric Brain Research and Intervention Center Institute for Juvenile Research University of Illinois at Chicago Department of Psychiatry 1747 West Roosevelt Road Chicago, Illinois 60608
A Big Thanks to Our Team! Pediatric BRAIN Center Alessandra Passarotti PhD Ezra Wegbreit PhD Lisa Lu PhD Binu Vargese MA Richard Whitley MA James Ellis BA Jacklynn Fitzgerald BA Jon O Neil BA Allison Lowes BA Meredith Wong BA Stephanie Monroe BA Bryn Levitan BA Nicole Witowski BA Nathan Carley BA Noah Yulish BA Gail Schuck BA Jean Madigan BA MRI Methodology Minjie Wu PhD Joe Zhou PhD Deb Little PhD Genomics and Neurochemistry Jeff Bishop Pharm D Christian Gossett BA Ghan Shyam Pandey PhD Yogesh Dwivedi PhD Clinical Sonali Nanayakkara MD Julie Carbray DNSc Amy West PhD Sally Weinstein PhD Collaborators John Sweeney PhD Mike Stevens PhD
Also incredibly thankful to NIH/NIMH 1R01MH081019A 1R01MH85639-01A1 RC1MH088462 HHSN275200503406C DANA Foundation NARSAD Foundation AFSP Marshall Reynolds Foundation Blue Harbor Foundation Berger-Colbeth Endowment