10 11 12 22 31 40. 49. 50 50..5 0 50 H G F E D C B A 1 2 3 4 5 6 7 8 9 57.0 49.5 0 40.5 0 31.5 0 22.5 0 36.5 0 Thermo Scientific Molecular Biology OEM Plastics Guide Precision manufacturing in PCR plastics Trusted partner for sustainable success of your PCR and business Custom PCRfocused product design, manufacturing, quality control and project management
Accuracy and reproducibility For more than 20 years, Thermo Fisher Scientific has been at the forefront of innovation in the manufacturing of high grade plastic consumables, with a focus on providing plastic solutions for molecular biology applications, including PCR and. The quality and reliability of our products enable you our customer to ensure the accuracy, reproducibility and validity of your biological data. We have the essentials to ensure that your development and manufacturing projects are a success Stateoftheart injection molding manufacturing facility located in the UK Custom development teams rapidly take ideas from concept, through design, prototyping, tool making, molding, quality control and logistics at one site Expertise in manufacturing with a wide range of different polymers Product assembly and packing knowhow to deliver exactly what you need, with the option to either receive white box products or to define your own requirements for custom manufacturing, barcoding, packaging and/or labeling Quality systems to respond to your evolving requirements with rigorous supply chain, manufacturing process and quality control documentation Dedicated account representatives to provide you with worldclass customer service We eliminate contaminants at the source, providing you with peace of mind All plastic consumables are produced in injection molding facilities that meet class 100,000 cleanroom (ISO 5 cleanroom) standards Virgin medicalgrade polypropylene Primary packaging is contained within class 100,000 cleanroom In vitro diagnostics (IVD) manufacturing requirements are met via a dedicated molding and packing installation running in a class 10,000 cleanroom (ISO 4 cleanroom) Production runs 24 hours a day, seven days a week according to ISO 9001 guidelines with complete traceability and process controls 2
Innovative product design High Efficiency, Reduced Variability Uniform, ultrathin well walls deliver maximum and consistent heat transfer for equally high performance from every sample. Secure, Easy Sealing Specially designed caps create a tight seal that is still easy to open and close. Strip tubes are available in individually attached cap versions. Height White Plastics for Enhanced Detection White plastics are designed to enable sensitive and accurate fluorescence detection by preventing refraction out of the tube and increasing the signaltonoise ratio. Evaporation Protection Raised rim design around each well enables secure sealing and safeguards against evaporation. Height Pitch 3
PCR tubes & strips SP0019, SP0018 SP0022, SP0021 Individual Tubes Compatible with standard 0.2 ml or 0.5 ml thermal cycler blocks Caps form a secure seal, yet are easy to open and close 0.2 ml tube height 20.70 mm 0.5 ml tube height 29.75 mm 0.2 ml Individual Tubes SP0018 w/flat Caps Clear SP0462 w/flat Caps Asstd. Col. SP0019 w/domed Caps Clear Pack Size: 1000 Tubes 0.5 ml Individual Tubes SP0021 w/flat Caps Clear SP0022 w/domed Caps Clear Pack Size: 1000 Tubes From top to bottom: SP1182, SP0020, SP1183 0.2 ml Strip Tubes Compatible with 0.2 ml thermal cycler blocks Optical caps ideal for use in assays Caps form a secure seal, yet are easy to apply and remove 8 tubes per strip Height 20.70 mm Pitch 9 mm 0.2 ml Strip Tubes SP1182 w/flat Caps Clear SP0020 w/domed Caps Clear SP0450 w/domed Caps Asstd. Col. Pack Size: 250 Tube Strips/Cap Strips 0.2 ml Individual Tubes SP1183 w/opticalcaps Clear SP1191 w/optical Caps White Pack Size: 120 Tube Strips/Cap Strips SP1504 SP1502/W Thermo Scientific EasyStrip Attached Cap Strip Tubes PCR strip tubes with individually attached caps for easy sample access Compatible with 0.2 ml thermal cycler blocks Optical cap options ideal for use in assays Height 20.70 mm Pitch 9 mm EasyStrips Attached Cap Strip Tubes SP1504 w/domed Caps Clear SP1502 w/optical Caps Clear SP1502/W w/optical Caps White Pack Size: 250 Strips Not available in US. 4
Low Profile Strip Tubes From top to bottom: SP0085, SP0094 Ideal strip for reaction volumes below 20 µl Compatible with 0.2 ml thermal cycler blocks Low profile to reduce dead space and increase PCR efficiency Labeled AH end tabs Height 15.50 mm Pitch 9 mm Low Profile Strip Tubes SP0085 Strips of 8 Low Profile Tubes SP0094 Strips of 8 Low Profile Tubes and Domed Caps (CP) Clear Clear Pack Size: 120 Tube Strips/Cap Strips 24 and 48Well SemiSkirted SP0036/SP0035 Conveniently precut into 24 or 48well segments Semi skirt adds rigidity and allows for labeling or barcoding Height 18.65 mm (SP0036), 18.65 mm (SP0035) Pitch 9 mm 24Well SemiSkirted (PreCut) SP0036 Clear 48Well SemiSkirted (PreCut) SP0035 Clear Pack Size: 50 Plates Pack Size: 50 Plates 96Well SemiSkirted, Segmented SP0127 Proprietary segmented plate design allows plates to be cut into 24 and 48well sections Semi skirt adds rigidity and allows for labeling or barcoding Cut corner: H1 Height 18.65 mm Pitch 9 mm H1 96Well SemiSkirted, Segmented SP0127 Clear SP0127/W White qpc R SP4896 96Well NonSkirted, FlexiPlate Segmented into 12 breakable strips Standard profile Height 19.30 mm Pitch 9 mm 96Well NonSkirted, FlexiPlate SP4896 Clear SP4896/W White 5
57.0 Choosing a plate Please refer to the following compatibility tables to find the Thermo Scientific plate suitable for your instrument. Plate model recommendations are based on the optimal PCR performance and ease of handling. Most recommended plates are either fully skirted or semiskirted as these plates offer increased rigidity, which reduces plate warping during thermal cycling, facilitates multichannel pipetting, and improves overall ease of use. Thermo Scientific Applied Biosystems (Life Technologies) BioRad (MJ Research) PCR PCR Sequencers PCR Legend Recommended Plate Alternative Option 96well Plate Type Piko 24 Piko 96 Arktik PikoReal 24 PikoReal 96 Veriti 384well Block Veriti 0.1ml 96well Block Veriti 0.2ml 96well Block GeneAmp 2700/2720, 9600 GeneAmp 9700 GeneAmp 9800 Fast Block 7000, 7300, 7500, 7700, 7900 7500 Fast, 7900HT with Fast 96well block 7900HT with standard 96well block 7900HT with 384 wellblock StepOne Plus 3130 Genetic Analyzer 3700 DNA Analyzer 3730, 3730XL DNA Analyzer T100, MJ Mini icycler, MyCycler C1000, S1000 PTC2(xx) PTC100 with 96well block icycler iq 4, iq 5, MyiQ, MyiQ2 CFX96 CFX384 Opticon MiniOpticon Fully Skirted Low Profile SP0037, SP3700 SemiSkirted Fast Block SP1900 Flat Deck SP0824, SP3600 Raised Skirt SP0446, SP3500 Segmented SP0127 NonSkirted Standard SP0074 StandardFlexi SP4896 Low Profile SP0029 24 or 48well 57.0 49.50 49.50 40.50 40.50 31.50 31.50 22.50 22.50 SemiSkirted Standard SP0036, SP0035 384well Standard Standard SP1384 1 2 3 4 5 6 7 8 9 10 11 12 Extra Volume SP0124 A 36.50 B C D E F G 40.00 22.50 22.50 31.50 31.50 80.00 H 55.00 6
1 2 3 4 5 6 7 8 9 10 1 A 36.50 B C Tip D E ions Lowprofile vers space air e th minimize action, re R PC e th above evaporation further reducing mmend that co effects. We re lowprofile e th you choose ailable. av e er wh options F G H 55.00 Additional Instruments Sequencing 57.0 49.50 40.50 Amersham 31.50 22.50 B C 3 Transg. 49.50 40.50 31.50 22.50 4 5 6 7 8 9 D E F G H 10 Wave MJ 2 BaseStation 1 MegaBACE 4000 A MegaBACE 500 Omnigene, OmnE MultiBlock System & MBS Thermo Scientific Hybaid PCR Express, Px2, PxE Takara TP 3000 TheQ Lifecycler Gene Technologies GS1, GS4, GSX Primus 384 Corbett Research Palm Cycler Primus 96 TCPlus Genius, Touchgene, TC512, TC5000 MWG PCR Flexigene, TC412, TC4000 TProfessional TRobot TGradient Uno II Uno PCR PCR Prime, PrimeQ Techne Techne TOptical Biometra Mastercycler ep Realplex M384 MasterCycler EP Gradient/Pro Mastercycler Gradient PCR Biometra 36.50 Mx3000P, Mx3005P Mx4000 Gradient Cycler Robocycler SureCycler 8800 PCR Eppendorf T1 Thermocycler Stratagene (Agilent) 55.00 7
PCR plates SP0037/SP3700 H1 96Well Fully Skirted, Low Profile ANSI footprint and stackable for use in automated systems Low profile to reduce dead space and increase PCR efficiency Available in a rigid version providing 4x more rigidity for superior robotic handling Cut corner: H1 Height 14 mm (SP0037), 13.10 mm (SP3700) Pitch 9 mm 96Well SemiSkirted, Low Block SP0037 Clear SP0037L Clear w/black letters SP0037/W White Rigid Version SP3700 Clear SP3700/W White SP1900 96Well SemiSkirted, Fast Block Directly compatible with Applied Biosystems fast blocks no need for adapter Raised plate deck to aid in spill prevention Cut corner: A1 Height 14.4 mm Pitch 9 mm A1 96Well SemiSkirted, Fast Block SP1900 Clear SP1900/W White SP0824/SP3600 A12 96Well SemiSkirted, Flat Deck Directly compatible with all Applied Biosystems platforms including sequencers with no adapters necessary Flat plate deck facilitates sealing and handling Available in a rigid version providing 4x rigidity for superior robotic handling Cut corner: A12 Height 19.30 mm (SP0824), 18.30 mm (SP3600) Pitch 9 mm 96Well SemiSkirted, Flat Deck SP0824 Clear SP0824L Clear w/black letters Rigid Version SP3600 Clear SP3600/W White 8
96Well SemiSkirted, Raised Deck SP0446/SP3500 Directly compatible with all Applied Biosystems platforms including sequencers with no adapters necessary Available in a rigid version providing 4x rigidity for superior robotic handling Cut corner: A12 Height 19.30 mm (SP0446), 18.30 mm (SP3500) Pitch 9 mm A12 96Well SemiSkirted, Raised Deck SP0446 Clear SP0446/W White qpc R Rigid Version SP3500 Clear SP3500/W White qpc R 96Well NonSkirted, Low Profile SP0029 Low profile to reduce dead space and increase PCR efficiency Available with black alphanumeric lettering Improved access for liquid handling Maximum well volume: 0.2 ml Cut corner: H12 Height 13.98 mm Pitch 9 mm H12 96Well NonSkirted, Low Profile SP0029 Clear SP0029/W White qpc R 96Well NonSkirted, Standard SP0074 Nonskirted format compatible with most thermal cyclers Available with black alphanumeric lettering Cut corner: H1 Height 19.30 mm Pitch 9 mm H1 96Well NonSkirted, Standard SP0074 Clear SP0074L Clear w/black letters SP1384 384Well Plates, FullSkirted, Standard Compatible with all leading 384block thermal cyclers Maximum well volume: 40 µl Also available in a larger volume format (SP0124) Cut corner: A24 Height 8 mm Pitch 4.50 mm A24 384Well FullSkirted, Standard SP1384 Clear Pack Size: 50 Plates 9
Sealing options We offer a wide range of robust sealing options to suit any application. All our sealing products are designed to provide the ultimate in sample protection while also being easy to use. PCR Cap Strips Seals Flat Cap Strips 1 Domed Cap Strips Optical Cap Strips PCR Foil Seal PCR Film Seal Optical Seal Part No. SP0361 SP0075 SP0100 (8 Caps per Strip) (8 Caps per Strip) (8 Caps per Strip) SP0028 SP0027 SP0605 Pack Size 250 Strips 250 Strips 120 Strips 100 Sheets 100 Sheets 50 Sheets Applications Mechanical Properties Resistance Compatible Products PCR (including waterbath) Sealing Temp Range 20 C to +120 C20 C to +120 C20 C to +120 C 40 C to +120 C20 C to +120 C80 C to +110 C Long Term Storage Pierceable 8.1 N Peelable Resealable Thickness 2 75 µm 255 µm 100 µm DMSO (100%) Ethanol (100%) Isopropanol (100%) Autoclavable UV Irradiation Gamma Irradiation Applicator Tools SP0078 SP0078 SP0078 SP1391 Tubes/Plates 8Strip PCR Tubes 96Well PCR Plates 8Strip PCR Tubes 96Well PCR Plates 8Strip PCR Tubes 96Well PCR Plates All Plates All Plates All Plates 1 Choose cap shape according to the instrument manufacturer's recommendation. 2 Does not include release liner. 10
The sealing options are optically clear to deliver maximum and consistent signal transmission, which is critical for accurate results. Seals Legend Successfully tested Storage Plate Sealing Not recommended Gas Permeable Seal Plate Seal Storage Plate Caps and Cap Strips SP0087 SP0443 SP0340 50 Sheets 100 Sheets 120 Strips of 8 Caps 50 Mats 50 Mats 20 C to +80 C 40 C to +80 C Sealing Mat (Pierceable) SP0077 (Round Well) SP0081 (Square Well) Sealing Mat (Autoclavable) SP0347 (Round Well) SP0093 (Square Well) 20 C to +55 C 20 C to +55 C 20 C to +130 C 6N 170 µm 55 µm Storage Plates Storage Plates Storage Plates All Plates All Plates 11
Storage plates Streamline your molecular biology applications with Thermo Scientific storage and assay plates. All plates are manufactured in our cleanroom facility to ensure molecular biologygrade quality. Our wide range of polypropylene plates provides excellent solutions for sample storage and assay set up, allowing dilutions and aliquots to be handled, stored or transported easily. All plates are ANSIformat for compatibility with automated systems. To further assist in storage and tracking, all plates can be supplied with custom barcoding. 48Well Plate Plate Model Pack Size Max Vol (Film Seal) Max Vol (Cap Seal) Max Vol (Mat Seal) SP0468 SP0084 SP0073 SP0080 SP0471 50 Plates 100 Plates 50 Plates 50 Plates 50 Plates 6 ml 330 µl 0.8 ml 1.2 ml 1.2 ml 250 µl 0.70 ml 1.1 ml 130 µl 0.55 ml 0.85 ml 1 ml Max Centrifugal Force not suitable for centrifugation 5000 g 2000 g 2000 g 2000 g Square Well Round Well Round Well Round Well Round Well Round Well Round Well Round Well Round Well Round Well Round Round Well Well Round Well Square Round Well Well Square Square Well Well Round Rou W Shape of Well Ubottomed Conical Pyramidal Ubottomed Ubottomed Ubottomed Conical Conical Conical Vbottomed Ubottomed Vbottomed Vbottomed Ubottomed Conical Ubottomed Ubottomed Conica Vb Compatible Sealing Film Compatible Mats SP0077 SP0347 SP0077 SP0347 SP0081 SP0093 12
Well Bottom Well Shape Round Wells Designed for optimal sample recovery Each well specifically designed with an independent sealing rim to prevent crosscontamination Ideally suited for use with the widest range of sealing options sistance Polypropylene Re DMSO (100%); Ideally suited for sample resuspension Vbottomed Virtually eliminates dead volume in tubes during liquid handling Square Wells Ethanol (100%); ); Isopropanol (100% n at 121 C); mi (15 le Autoclavab n. Gamma Irradiatio Conical/Pyramidal Angled well corners reduce the capillary action of liquids, preventing crosscontamination between wells Improved sample recovery and decreased dead volume Square shape maximizes well volume within ANSI footprint design 96Well Plate 384Well Plate SP0092 SP0103 SP0283 SP0925 SP0089 SP0466 SP0467 50 Plates 50 Plates 50 Plates 50 Plates 50 Plates 50 Plates 50 Plates 2.2 ml 2.2 ml 300 µl 250 µl 120 µl 70 µl 55 µl 1.8 ml 1.8 ml 30 µl 25 µl 5000 g 5000 g 5000 g 5000 g 5000 g 5000 g 5000 g Square Well Round Well Well Well Well Well Well Well Round Well Well Square Well WellRound Round Well WellSquare Round Well Well Round d Well Round Square Round Round Round Round Square Well Round tomed Tip Ubottomed Ubottomed Pyramidal Conical Ubottomed ConicalConical Ubottomed Pyramidal UbottomedVbottomed Pyramidal Conical VbottomedConical Ubottomed Conical Conical Well Well Round Well RoundRound WellRound Round Well Round Well Round Well Round Well S Pyramidal Pyramidal Ubottomed Ubottomed Conical Conical Vbottomed Vbottomed U SP0081 SP0093 SP0081 SP0093 AB1171 AB1171 13
Custom products Every aspect of your product can be tailored to meet both application and your customer s needs, from the product itself to the label on the box. Product Offtheshelf options are available for most life science consumables: PCR tubes, strip tubes and 24 to 384well PCR plates along with storage plates from 5 μl to 6 ml and a wide range of plate seals Any of the offtheshelf products can be customized to individual requirements, including colored lettering, unique adhesive seal formats and different colored stripes on tube strips to indicate different diagnostic tests If none of the existing products quite match your instrument or application then our R&D team will work with you to understand all the product requirements and design a consumable that uniquely fits your platform Product Format Standard pack sizes are available for offtheshelf products; individually wrapped, handy small pack sizes or bulk options are available for high throughput users All of the products can be supplied in any pack size from a kitready custom component bag containing 5 seals bearing a lot number label to a pack of 5000 strip tubes ready for reagent loading in your facility Packaging Our standard products are supplied in white boxes with plain, nonbranded labels All OEM products can be supplied with any or all of the following customized components: Labels printed in our manufacturing site or supplied to us ready for the final packaging stage Unique lot numbers Product information inserts Certificates of conformity Outer packaging from specific finish to box design Make us a part of your team, contact an OEM specialist at thermoscientific.com/oempartner 14
1 Idea 2 Technical product drawing 3 3D prototype of product 4 Mold design and assembly 5 Manufacturing 6 Quality control 7 Custom packaging 8 Finished product 15
Custom design and prototypes Existing clients spanning the diagnostics, therapeutics and research markets value our expertise in new product design and prototyping. Our design team delivers creativity with the ability to produce reliable and accurate plastic solutions for scientific applications. The team has an excellent record in bringing innovative, profitable and highly engineered products to market within customerdefined time frames. Communication is the key. Our designers, engineers and molecular biologists are ready to listen to your team so we can develop products that meet and perhaps exceed your expectations. Tools we use to design your products include Premold conceptual designs using SolidWorks 3D CAD software Computergenerated stereo lithography apparatus (SLA) to create solid, plastic, 3D objects from CAD drawings Rapid prototyping in polypropylene to provide fully functional samples before mold production We develop integrative partnerships with our customers, providing the highest quality products and tailored support services from concept through manufacturing scaleup. Whether you are a large corporation or a startup company, we offer you quality plastics components, quickly and reliably, at any volumes. Understanding your requirements is the foundation of our business. Make us a part of your team, contact an OEM specialist at thermoscientific.com/oempartner 16
Custom manufacturing Injection molding is the technique used for the reproducible production of identical, highprecision components. We use only medicalgrade polymers in this process, and our engineers are continually improving the technology we use to develop and manufacture products. Molds are made using the latest machinecutting technology, before being handfinished by our highly skilled craftsmen. Every new manufacturing project requires the development and creation of a new tool and we have made hundreds. Development of custommade press tools, robots and molds using a design team and tool team that work at the same site Pioneers in the manufacturing of thinwalled plastic consumables for PCRbased technologies A dedicated project management team oversees development projects and maintains customer client relationships 17
Custom barcoding services Tracking of samples is important to many customers so we offer the ability to have your plates produced with barcode sequences unique to your product in any common barcode format. Design the perfect barcoding * solution to fit your unique needs Choose plates for the ultimate barcoding flexibility Plate Type Any fully skirted or semiskirted plate from the entire range of PCR and storage plates Barcode Format Code 128, Code 39, Interleaved 2 of 5, with flexible humanreadable code position Label Size Available in standard label sizes or customizable according to requirements Barcode Density Range of dimensions available Sequence You determine start to end sequence and alphanumeric pattern Positioning Any code on any side, all the same code or varied Barcode Format Options Barcode Type Code 128 Code 39 Code interleaved 2 from 5 Multiplier 7 mils 10 mils 13 mils *1000 plate minimum orders. Smaller quantities may be possible, but are subject to an order fee. Please inquire. 57.0 49.50 49.50 40.50 40.50 31.50 31.50 22.50 22.50 36.50 A B 1 2 3 4 5 6 7 8 9 10 11 12 C D E F G 18 H
The definitive quality control, adapted to your needs We are ISO 9001registered, and our quality systems are the cornerstone of our business. Rigorous standards of product testing and process controls include comprehensive standard operating procedures (SOPs). This includes referencing to master samples; biological assay testing; plastic integrity testing; 24 hours a day, seven days a week roving QC patrols to ensure procedural adherence; equipment qualification; process verification and validation. A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply. Timeanddate batch segregation of every production run prior to QA release Onsite coordinate measuring machines validate that tools and moldings adhere to specified product tolerances Formalized change control process to ensure consistency, compliance and conformance of materials Raw material and vendor qualifications that provide security of supply Corrective and preventative action systems Applicationspecific testing ensures product performance in functional assays; e.g. /PCR testing, centrifugation and sealing/storage conditions Our employees use these systems in daytoday activities and take great pride in consistently meeting our customers requirements and exceeding your expectations for service We encourage customers to tour and audit our UKbased facility Make us a part of your team, contact an OEM specialist at thermoscientific.com/oempartner 19
Customer service Because longterm relationships with our customers are our goal, we focus on delivering the standard of service that only highly experienced staff members can provide. We are committed to communication, we are responsive and we deliver on our promises. Your business will be assigned a team with the experience and organizational contacts to deliver your requirements We provide prompt, accurate responses to questions, documentation requests, and technical support We take your confidentiality very seriously Make us a part of your team, contact an OEM specialist at thermoscientific.com/oempartner MB1405 2014 Thermo Fisher Scientific Inc. All rights reserved. The trademarks used on pages 67 are owned by the manufacturer's of the respective instruments, as indicated on those pages. All other trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. Europe United States Customer Service cs.molbio.eu@thermofisher.com Customer Service B2BGenPlastics.PierceCS@thermofisher.com Technical Support ts.molbio.eu@thermofisher.com Technical Support ts.molbio.eu@thermofisher.com Tel 00800 222 00 888 Fax 00800 222 00 889 Tel 1 800 235 9880 (press 1) 1 800 292 6088